<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:2a17abfd-895e-4167-a86d-7d9f690e3e6d,g:e9cf18bf-566c-4538-bd03-9784438a13e0-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_aeb542a1-3ef0-453c-a6c2-3b5b6cdec34d" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_ProvisionsForOtherLiabilitiesAndCharges_57443204-85f0-42e0-b129-d5fab5bd5c51" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_ProvisionsForOtherLiabilitiesAndCharges"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_aeb542a1-3ef0-453c-a6c2-3b5b6cdec34d" xlink:to="loc_san_ProvisionsForOtherLiabilitiesAndCharges_57443204-85f0-42e0-b129-d5fab5bd5c51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_2dc4393b-1b6b-4377-ad85-9ca1f8fab12f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_aeb542a1-3ef0-453c-a6c2-3b5b6cdec34d" xlink:to="loc_ifrs-full_ImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_2dc4393b-1b6b-4377-ad85-9ca1f8fab12f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_6b9eed2a-efdc-4ec4-abfb-0d7a2233b71e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_131f9185-7278-4f8c-8533-f99555d532b4" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_6b9eed2a-efdc-4ec4-abfb-0d7a2233b71e" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_131f9185-7278-4f8c-8533-f99555d532b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_f7bf44e6-4b45-4715-ace7-17bb854319dd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_6b9eed2a-efdc-4ec4-abfb-0d7a2233b71e" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_f7bf44e6-4b45-4715-ace7-17bb854319dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionIncomeExpense_ad77c94f-6a97-438a-b6f5-ec69eab718b8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FeeAndCommissionIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionExpense_58903735-b76d-417d-8b6b-86064b33f424" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FeeAndCommissionExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FeeAndCommissionIncomeExpense_ad77c94f-6a97-438a-b6f5-ec69eab718b8" xlink:to="loc_ifrs-full_FeeAndCommissionExpense_58903735-b76d-417d-8b6b-86064b33f424" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionIncome_3a827135-825f-43ea-8eef-8cbd95c438b4" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FeeAndCommissionIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FeeAndCommissionIncomeExpense_ad77c94f-6a97-438a-b6f5-ec69eab718b8" xlink:to="loc_ifrs-full_FeeAndCommissionIncome_3a827135-825f-43ea-8eef-8cbd95c438b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueAndOperatingIncome_b077c0d1-7dcc-406f-a5d9-b4b26af7e064" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueAndOperatingIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_034224dc-3e33-443e-9fe1-6aba5a5ad343" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueAndOperatingIncome_b077c0d1-7dcc-406f-a5d9-b4b26af7e064" xlink:to="loc_ifrs-full_OtherOperatingIncomeExpense_034224dc-3e33-443e-9fe1-6aba5a5ad343" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionIncomeExpense_bbcb0545-f12c-45b8-95f1-6ce213da181b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FeeAndCommissionIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueAndOperatingIncome_b077c0d1-7dcc-406f-a5d9-b4b26af7e064" xlink:to="loc_ifrs-full_FeeAndCommissionIncomeExpense_bbcb0545-f12c-45b8-95f1-6ce213da181b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestRevenueExpense_cf3fdd75-cf26-4413-b684-09bf14a990f7" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestRevenueExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueAndOperatingIncome_b077c0d1-7dcc-406f-a5d9-b4b26af7e064" xlink:to="loc_ifrs-full_InterestRevenueExpense_cf3fdd75-cf26-4413-b684-09bf14a990f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_7594cc5b-84c6-4071-844f-44ebc239762a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueAndOperatingIncome_e1bc6147-82a9-4e41-9812-178d267b20c8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueAndOperatingIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_7594cc5b-84c6-4071-844f-44ebc239762a" xlink:to="loc_ifrs-full_RevenueAndOperatingIncome_e1bc6147-82a9-4e41-9812-178d267b20c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OperatingExpensesBeforeCreditImpairmentChargesWriteBacksProvisionsAndCharges_6dd1753d-e6f2-4f29-abfd-19f67652c8e2" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_OperatingExpensesBeforeCreditImpairmentChargesWriteBacksProvisionsAndCharges"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_7594cc5b-84c6-4071-844f-44ebc239762a" xlink:to="loc_san_OperatingExpensesBeforeCreditImpairmentChargesWriteBacksProvisionsAndCharges_6dd1753d-e6f2-4f29-abfd-19f67652c8e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_164c2f1d-d879-47e3-9786-d2db5b5cb806" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_7594cc5b-84c6-4071-844f-44ebc239762a" xlink:to="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_164c2f1d-d879-47e3-9786-d2db5b5cb806" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestRevenueExpense_1cde1f61-65bc-4de1-95f0-63ed1b0cc3b3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestRevenueExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpense_2ef917f0-dda8-4c94-87b0-6bbc5e76b0e2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_InterestRevenueExpense_1cde1f61-65bc-4de1-95f0-63ed1b0cc3b3" xlink:to="loc_ifrs-full_InterestExpense_2ef917f0-dda8-4c94-87b0-6bbc5e76b0e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromInterest_6e7194b3-17b6-4c61-b33b-7347371fc114" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_InterestRevenueExpense_1cde1f61-65bc-4de1-95f0-63ed1b0cc3b3" xlink:to="loc_ifrs-full_RevenueFromInterest_6e7194b3-17b6-4c61-b33b-7347371fc114" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_65c879f5-bbc1-4744-bd3d-c02b6647b627" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_f76534ce-ce43-4481-8f3b-a7e335342913" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_65c879f5-bbc1-4744-bd3d-c02b6647b627" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_f76534ce-ce43-4481-8f3b-a7e335342913" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_a158187e-7f88-49b7-8d38-c753ace8e967" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_91480bbc-8d0a-4a52-afea-3922047f5dd0" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_a158187e-7f88-49b7-8d38-c753ace8e967" xlink:to="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_91480bbc-8d0a-4a52-afea-3922047f5dd0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_618d50af-96ac-40a9-aaf4-3d563a736b6e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_a158187e-7f88-49b7-8d38-c753ace8e967" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_618d50af-96ac-40a9-aaf4-3d563a736b6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_f2c41d39-1828-4eb7-980d-363b4cc215aa" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_8711a568-0277-4ad1-bf14-ea92076bfab3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_f2c41d39-1828-4eb7-980d-363b4cc215aa" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_8711a568-0277-4ad1-bf14-ea92076bfab3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_cc0005ba-7e99-428c-b6c6-5f7a361961f9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_f2c41d39-1828-4eb7-980d-363b4cc215aa" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_cc0005ba-7e99-428c-b6c6-5f7a361961f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_8811bd2b-fb22-40d3-a991-ba539f26bf03" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_53376a02-3621-4195-8d09-c319e702381a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_8811bd2b-fb22-40d3-a991-ba539f26bf03" xlink:to="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_53376a02-3621-4195-8d09-c319e702381a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReclassificationAdjustmentsOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_71d03d30-8213-4cd4-9a0d-78a1981621c2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ReclassificationAdjustmentsOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_8811bd2b-fb22-40d3-a991-ba539f26bf03" xlink:to="loc_ifrs-full_ReclassificationAdjustmentsOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_71d03d30-8213-4cd4-9a0d-78a1981621c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_a9277f69-1ea6-446c-9b8f-33a9fcd2ad30" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxRelatingToFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_8811bd2b-fb22-40d3-a991-ba539f26bf03" xlink:to="loc_ifrs-full_IncomeTaxRelatingToFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_a9277f69-1ea6-446c-9b8f-33a9fcd2ad30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_114aa3fb-3dd6-4e7c-89bc-ff881dd835cd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToChangesInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiabilityOfOtherComprehensiveIncome_f782bbcb-e640-43d9-b9e0-2ad65b2b4833" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxRelatingToChangesInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiabilityOfOtherComprehensiveIncome"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_114aa3fb-3dd6-4e7c-89bc-ff881dd835cd" xlink:to="loc_ifrs-full_IncomeTaxRelatingToChangesInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiabilityOfOtherComprehensiveIncome_f782bbcb-e640-43d9-b9e0-2ad65b2b4833" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_dce70cca-5c18-4f72-9ae8-e75543f83925" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_114aa3fb-3dd6-4e7c-89bc-ff881dd835cd" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_dce70cca-5c18-4f72-9ae8-e75543f83925" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_9c592552-63ea-4e0f-9916-ea4f896d366b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_43ee0c52-ca86-4a25-880a-b5c175351b83" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_9c592552-63ea-4e0f-9916-ea4f896d366b" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_43ee0c52-ca86-4a25-880a-b5c175351b83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_b2115d42-6392-4736-998f-20095d48c908" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_9c592552-63ea-4e0f-9916-ea4f896d366b" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_b2115d42-6392-4736-998f-20095d48c908" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_1412e3cd-a15b-4276-9ad2-c3b5af8fb7cf" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_8cfb8abc-8635-4154-a2b5-6b915067edad" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_1412e3cd-a15b-4276-9ad2-c3b5af8fb7cf" xlink:to="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_8cfb8abc-8635-4154-a2b5-6b915067edad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_a496c678-77ee-4de0-a2d4-603282b4bc7a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_1412e3cd-a15b-4276-9ad2-c3b5af8fb7cf" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_a496c678-77ee-4de0-a2d4-603282b4bc7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_287733a8-2791-47c7-862b-2310d48bb27d" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_cf0474ed-a151-4770-8cc6-756d1fa9679e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_287733a8-2791-47c7-862b-2310d48bb27d" xlink:to="loc_ifrs-full_ProfitLoss_cf0474ed-a151-4770-8cc6-756d1fa9679e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_7d744287-426b-4d71-9bfe-ebfc9e57b222" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_287733a8-2791-47c7-862b-2310d48bb27d" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_7d744287-426b-4d71-9bfe-ebfc9e57b222" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_3eedc0ad-b8df-4c05-9e23-7f643a4bce52" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesBeforeTax_f4c9b23f-d620-4799-8bba-c3e6c88b1b2c" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_3eedc0ad-b8df-4c05-9e23-7f643a4bce52" xlink:to="loc_ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesBeforeTax_f4c9b23f-d620-4799-8bba-c3e6c88b1b2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome_0bc249ad-a81a-40e2-a4f7-02dd066ba83d" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_3eedc0ad-b8df-4c05-9e23-7f643a4bce52" xlink:to="loc_ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome_0bc249ad-a81a-40e2-a4f7-02dd066ba83d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_10342791-78c6-41cc-b90e-26c65be13cfd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_3eedc0ad-b8df-4c05-9e23-7f643a4bce52" xlink:to="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_10342791-78c6-41cc-b90e-26c65be13cfd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_706ea35b-1e89-476e-9775-2cf83df30f6c" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_476cbe0b-ffc7-4610-910a-062bbea5d5d4" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_706ea35b-1e89-476e-9775-2cf83df30f6c" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_476cbe0b-ffc7-4610-910a-062bbea5d5d4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#StatementoffinancialpositioncurrentnoncurrentStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_MacroHedgeOfInterestRateRiskAsset_875fb97f-ff27-4615-9e5f-9741d603e655" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_MacroHedgeOfInterestRateRiskAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_san_MacroHedgeOfInterestRateRiskAsset_875fb97f-ff27-4615-9e5f-9741d603e655" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RecognisedAssetsDefinedBenefitPlan_b97fe14a-8a59-4e63-bc05-53958cc1f44f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RecognisedAssetsDefinedBenefitPlan"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_RecognisedAssetsDefinedBenefitPlan_b97fe14a-8a59-4e63-bc05-53958cc1f44f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsAndGoodwill_a2941b29-74aa-4554-8558-6109f923253d" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IntangibleAssetsAndGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_IntangibleAssetsAndGoodwill_a2941b29-74aa-4554-8558-6109f923253d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherFinancialAssetsAtFairValueThroughProfitOrLoss_cc8328b0-fb4e-4a5d-9821-c24524af7e46" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_OtherFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_san_OtherFinancialAssetsAtFairValueThroughProfitOrLoss_cc8328b0-fb4e-4a5d-9821-c24524af7e46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssets_05e25dad-dd8b-421b-9157-d79b8e7de9d5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTaxAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_CurrentTaxAssets_05e25dad-dd8b-421b-9157-d79b8e7de9d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_2711ee1a-86bc-4c0b-a835-cfc447bdcee2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_ReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_2711ee1a-86bc-4c0b-a835-cfc447bdcee2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndBankBalancesAtCentralBanks_576a305b-80d6-40bc-8c67-c7415d870144" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashAndBankBalancesAtCentralBanks"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_CashAndBankBalancesAtCentralBanks_576a305b-80d6-40bc-8c67-c7415d870144" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialAssetsAtFairValueThroughOtherComprehensiveIncome_86823621-1730-4784-84c2-8f70e10dc1af" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FinancialAssetsAtFairValueThroughOtherComprehensiveIncome"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_FinancialAssetsAtFairValueThroughOtherComprehensiveIncome_86823621-1730-4784-84c2-8f70e10dc1af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherFinancialAssetsAtAmortisedCost_5cb2a5d8-ba0a-43ec-9ed2-5ccb1e53c8ed" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_OtherFinancialAssetsAtAmortisedCost"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_san_OtherFinancialAssetsAtAmortisedCost_5cb2a5d8-ba0a-43ec-9ed2-5ccb1e53c8ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_dc63b42a-984a-4940-b114-c1aec9998747" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_dc63b42a-984a-4940-b114-c1aec9998747" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialAssets_f3d1e502-8f02-4f6d-8000-e8635ea8d8eb" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DerivativeFinancialAssets"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_DerivativeFinancialAssets_f3d1e502-8f02-4f6d-8000-e8635ea8d8eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_PropertyPlantAndEquipmentIncludingRightOfUseAssets_91205a96-6f3d-49bb-b19f-2d820318abe5" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_PropertyPlantAndEquipmentIncludingRightOfUseAssets"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_san_PropertyPlantAndEquipmentIncludingRightOfUseAssets_91205a96-6f3d-49bb-b19f-2d820318abe5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentsInJointVenturesAccountedForUsingEquityMethod_bed5295f-9c17-475d-8871-92b328fe1483" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InvestmentsInJointVenturesAccountedForUsingEquityMethod"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_InvestmentsInJointVenturesAccountedForUsingEquityMethod_bed5295f-9c17-475d-8871-92b328fe1483" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LoansAndAdvancesToCustomers_91017629-d8f6-4218-bb56-1a76463dd923" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LoansAndAdvancesToCustomers"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_LoansAndAdvancesToCustomers_91017629-d8f6-4218-bb56-1a76463dd923" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAssets_9bc97e65-f4c3-4b64-b323-3a683b187259" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherAssets"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_OtherAssets_9bc97e65-f4c3-4b64-b323-3a683b187259" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LoansAndAdvancesToBanks_e66b7272-0b17-41bf-9804-9e60eeef3310" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LoansAndAdvancesToBanks"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_bd3fb178-c747-404d-afe9-be4d33c5e7e2" xlink:to="loc_ifrs-full_LoansAndAdvancesToBanks_e66b7272-0b17-41bf-9804-9e60eeef3310" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_e1986449-2a81-4f26-b91d-17688025a7eb" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_7babe57a-ac95-4823-af3c-794d53433937" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_e1986449-2a81-4f26-b91d-17688025a7eb" xlink:to="loc_ifrs-full_Equity_7babe57a-ac95-4823-af3c-794d53433937" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_7afe1cd4-daa5-4b64-b7cb-b15a1b57acc0" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_e1986449-2a81-4f26-b91d-17688025a7eb" xlink:to="loc_ifrs-full_Liabilities_7afe1cd4-daa5-4b64-b7cb-b15a1b57acc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_7dbfbae8-cd44-436d-a345-e2225255f9b7" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_acb5eec1-5e70-45fe-89c5-97c0e4866a06" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RetainedEarnings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_7dbfbae8-cd44-436d-a345-e2225255f9b7" xlink:to="loc_ifrs-full_RetainedEarnings_acb5eec1-5e70-45fe-89c5-97c0e4866a06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_5766c4af-c53b-46c8-99bf-c87b2bf648e0" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SharePremium"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_7dbfbae8-cd44-436d-a345-e2225255f9b7" xlink:to="loc_ifrs-full_SharePremium_5766c4af-c53b-46c8-99bf-c87b2bf648e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_266aaedb-ae75-47eb-939c-bc2ce7c57581" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_7dbfbae8-cd44-436d-a345-e2225255f9b7" xlink:to="loc_ifrs-full_IssuedCapital_266aaedb-ae75-47eb-939c-bc2ce7c57581" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_5921b8d0-d2d0-44b0-b708-84c9ef151cec" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_7dbfbae8-cd44-436d-a345-e2225255f9b7" xlink:to="loc_ifrs-full_OtherReserves_5921b8d0-d2d0-44b0-b708-84c9ef151cec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherEquityInterest_bef12a70-13bd-48d8-8b62-8f109cf0a806" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherEquityInterest"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_7dbfbae8-cd44-436d-a345-e2225255f9b7" xlink:to="loc_ifrs-full_OtherEquityInterest_bef12a70-13bd-48d8-8b62-8f109cf0a806" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_MacroHedgeOfInterestRateRiskLiability_464056f2-6a22-4d2f-85b6-918f60967b80" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_MacroHedgeOfInterestRateRiskLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_san_MacroHedgeOfInterestRateRiskLiability_464056f2-6a22-4d2f-85b6-918f60967b80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DebtSecurities_896f17c9-89a4-488a-bc47-a5b91a1ade61" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_DebtSecurities_896f17c9-89a4-488a-bc47-a5b91a1ade61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_8972a4ac-d425-4321-956c-3f9fd5ce42ad" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_OtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_san_OtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_8972a4ac-d425-4321-956c-3f9fd5ce42ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Provisions_f3e4e750-0f06-44d5-b240-edb4f46e44b2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Provisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_Provisions_f3e4e750-0f06-44d5-b240-edb4f46e44b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RecognisedLiabilitiesDefinedBenefitPlan_00c9847e-8721-4b3e-a286-5e782486a717" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RecognisedLiabilitiesDefinedBenefitPlan"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_RecognisedLiabilitiesDefinedBenefitPlan_00c9847e-8721-4b3e-a286-5e782486a717" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepurchaseAgreementsAndCashCollateralOnSecuritiesLent_a5c5056d-bd7b-414a-bdf5-7e154bd17da5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RepurchaseAgreementsAndCashCollateralOnSecuritiesLent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_RepurchaseAgreementsAndCashCollateralOnSecuritiesLent_a5c5056d-bd7b-414a-bdf5-7e154bd17da5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepositsFromCustomers_b7f800d5-216c-42cc-bf7f-6247a119a745" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DepositsFromCustomers"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_DepositsFromCustomers_b7f800d5-216c-42cc-bf7f-6247a119a745" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialLiabilities_d63b31d3-47ae-4121-8c68-534d56006bf6" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DerivativeFinancialLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_DerivativeFinancialLiabilities_d63b31d3-47ae-4121-8c68-534d56006bf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetDeferredTaxLiabilities_cd48eba3-10d4-41bd-9618-23c90b09616f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NetDeferredTaxLiabilities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_NetDeferredTaxLiabilities_cd48eba3-10d4-41bd-9618-23c90b09616f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SubordinatedLiabilities_268333a7-31b0-47da-9636-59badefe2b73" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SubordinatedLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_SubordinatedLiabilities_268333a7-31b0-47da-9636-59badefe2b73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepositsFromBanks_d516fe43-ee3e-4857-a355-547f50237a6b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DepositsFromBanks"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_DepositsFromBanks_d516fe43-ee3e-4857-a355-547f50237a6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherLiabilities_be1ad8f4-4219-4632-bf56-b531d9d69778" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_58ffeaa1-71d2-458b-94b1-6f8668aeb2ea" xlink:to="loc_ifrs-full_OtherLiabilities_be1ad8f4-4219-4632-bf56-b531d9d69778" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcashflowsindirectmethodDetails" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#StatementofcashflowsindirectmethodDetails"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcashflowsindirectmethodDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInOtherFinancialAssetsAtFairValueThroughProfitOrLoss_1e04aec7-79de-4638-948d-04d9fea9c6b6" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInOtherFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInOtherFinancialAssetsAtFairValueThroughProfitOrLoss_1e04aec7-79de-4638-948d-04d9fea9c6b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets_5de418eb-f41c-4ae8-aaff-d6b7d6760fd5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets_5de418eb-f41c-4ae8-aaff-d6b7d6760fd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInCashAndBalancesAtCentralBanks_3dbc9181-40b0-4825-ba08-e58e354556ad" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInCashAndBalancesAtCentralBanks"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInCashAndBalancesAtCentralBanks_3dbc9181-40b0-4825-ba08-e58e354556ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_42146fda-82d9-436b-9387-019ac3be7aa2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_42146fda-82d9-436b-9387-019ac3be7aa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities_315f12e7-8c19-4aad-80da-e4793999ccc3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities_315f12e7-8c19-4aad-80da-e4793999ccc3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForIncreaseDecreaseInDepositsFromBanksAndCustomers_4b3f284a-9395-4291-86ae-545e36586e92" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForIncreaseDecreaseInDepositsFromBanksAndCustomers"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_san_AdjustmentsForIncreaseDecreaseInDepositsFromBanksAndCustomers_4b3f284a-9395-4291-86ae-545e36586e92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForIncreaseDecreaseInDebtInstrumentsInIssued_036139fe-c627-42bf-a61e-9ca61d3c7de3" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForIncreaseDecreaseInDebtInstrumentsInIssued"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_san_AdjustmentsForIncreaseDecreaseInDebtInstrumentsInIssued_036139fe-c627-42bf-a61e-9ca61d3c7de3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInDerivativeFinancialAssets_538ae6cd-a7bb-4fcf-87ec-21592d2b45fe" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInDerivativeFinancialAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInDerivativeFinancialAssets_538ae6cd-a7bb-4fcf-87ec-21592d2b45fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInRepurchaseAgreementsAndCashCollateralOnSecuritiesLent_e527b5d4-1135-467d-a3f1-22a7b65d0ded" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInRepurchaseAgreementsAndCashCollateralOnSecuritiesLent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInRepurchaseAgreementsAndCashCollateralOnSecuritiesLent_e527b5d4-1135-467d-a3f1-22a7b65d0ded" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInLoansAndAdvancesToBanksAndCustomers_58b43b5f-46d0-4379-aa3f-ec3188e115fe" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInLoansAndAdvancesToBanksAndCustomers"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInLoansAndAdvancesToBanksAndCustomers_58b43b5f-46d0-4379-aa3f-ec3188e115fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForIncreaseDecreaseInOtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_329840ff-6e16-4623-86d0-9fb554b57984" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForIncreaseDecreaseInOtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_san_AdjustmentsForIncreaseDecreaseInOtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_329840ff-6e16-4623-86d0-9fb554b57984" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities_dcc45621-ad6f-4382-ae00-f4a730bb8f94" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_d3a659a1-a028-4530-9544-490ca7479916" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities_dcc45621-ad6f-4382-ae00-f4a730bb8f94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4693bdac-f712-4381-b645-8449693e2974" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e904be41-9ad8-445c-ba16-756115a307ba" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4693bdac-f712-4381-b645-8449693e2974" xlink:to="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e904be41-9ad8-445c-ba16-756115a307ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_73fbc0bc-c5f4-45e3-ad81-4aa9638923d0" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4693bdac-f712-4381-b645-8449693e2974" xlink:to="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_73fbc0bc-c5f4-45e3-ad81-4aa9638923d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_75e479a8-6b65-48d7-b5fe-b69e244623aa" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4693bdac-f712-4381-b645-8449693e2974" xlink:to="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_75e479a8-6b65-48d7-b5fe-b69e244623aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_05aa2a4c-d8a9-4f43-8bf3-0691ed48cc95" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4693bdac-f712-4381-b645-8449693e2974" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_05aa2a4c-d8a9-4f43-8bf3-0691ed48cc95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_82f624aa-28bc-4157-bd8b-063b1ed11326" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4693bdac-f712-4381-b645-8449693e2974" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_82f624aa-28bc-4157-bd8b-063b1ed11326" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_acc969a2-f07f-4580-8a1b-31e8fdbf85f7" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96bd9c44-b0d3-4614-bb3b-7cee1d138abd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_acc969a2-f07f-4580-8a1b-31e8fdbf85f7" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96bd9c44-b0d3-4614-bb3b-7cee1d138abd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_6e4e3da9-a183-43c7-8182-7e10b229b69d" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_acc969a2-f07f-4580-8a1b-31e8fdbf85f7" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_6e4e3da9-a183-43c7-8182-7e10b229b69d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a40cfe71-3335-4da1-a733-a3409c8f5b5b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_acc969a2-f07f-4580-8a1b-31e8fdbf85f7" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a40cfe71-3335-4da1-a733-a3409c8f5b5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_89a06be4-e6b7-4033-a14c-27149722e552" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_f9c24ae6-7175-4c7b-a659-875e6b985c1f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_89a06be4-e6b7-4033-a14c-27149722e552" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_f9c24ae6-7175-4c7b-a659-875e6b985c1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_dfbc5d05-c39b-4220-a84c-32d476c9adf2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_89a06be4-e6b7-4033-a14c-27149722e552" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_dfbc5d05-c39b-4220-a84c-32d476c9adf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_446ccee1-df83-4651-97a1-f95991aaadef" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_89a06be4-e6b7-4033-a14c-27149722e552" xlink:to="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_446ccee1-df83-4651-97a1-f95991aaadef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForProvisions_ee9eb808-bceb-4420-9939-f1f6604261c9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_89a06be4-e6b7-4033-a14c-27149722e552" xlink:to="loc_ifrs-full_AdjustmentsForProvisions_ee9eb808-bceb-4420-9939-f1f6604261c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_5207ea40-ac58-4cc3-a300-7eace34f1ba9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_89a06be4-e6b7-4033-a14c-27149722e552" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_5207ea40-ac58-4cc3-a300-7eace34f1ba9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_5e4a6a43-70ef-4825-8088-cbc0524fda38" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_89a06be4-e6b7-4033-a14c-27149722e552" xlink:to="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_5e4a6a43-70ef-4825-8088-cbc0524fda38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a43b2e06-9289-4ec5-9fcb-123e9ba7b97a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_815758f1-b9f2-4645-aac6-86507804c0f5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a43b2e06-9289-4ec5-9fcb-123e9ba7b97a" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_815758f1-b9f2-4645-aac6-86507804c0f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_62fe0233-4e52-4a9a-bb36-dc3adeff1aee" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a43b2e06-9289-4ec5-9fcb-123e9ba7b97a" xlink:to="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_62fe0233-4e52-4a9a-bb36-dc3adeff1aee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_138155e1-3a94-4400-a3cc-ade170808f81" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a43b2e06-9289-4ec5-9fcb-123e9ba7b97a" xlink:to="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_138155e1-3a94-4400-a3cc-ade170808f81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_896a0df9-250e-406e-9380-25424d41f3be" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a43b2e06-9289-4ec5-9fcb-123e9ba7b97a" xlink:to="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_896a0df9-250e-406e-9380-25424d41f3be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_234ff1ba-33b2-4a09-9620-553440e84627" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BankBalancesAtCentralBanksOtherThanMandatoryReserveDeposits_df2a4874-26a8-44fd-a50d-c61bc670de52" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_BankBalancesAtCentralBanksOtherThanMandatoryReserveDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_234ff1ba-33b2-4a09-9620-553440e84627" xlink:to="loc_ifrs-full_BankBalancesAtCentralBanksOtherThanMandatoryReserveDeposits_df2a4874-26a8-44fd-a50d-c61bc670de52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherCashEquivalentsLoansAndAdvancesToBanksNonTrading_14081b6a-8a7c-4294-bee4-ad6939a42f97" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_OtherCashEquivalentsLoansAndAdvancesToBanksNonTrading"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_234ff1ba-33b2-4a09-9620-553440e84627" xlink:to="loc_san_OtherCashEquivalentsLoansAndAdvancesToBanksNonTrading_14081b6a-8a7c-4294-bee4-ad6939a42f97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsForDebtIssueCosts_7937ba72-fe3e-4386-abc5-27c34093e8ed" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PaymentsForDebtIssueCosts"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_ifrs-full_PaymentsForDebtIssueCosts_7937ba72-fe3e-4386-abc5-27c34093e8ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfOtherEquityInstruments_94a30d96-6fd7-4c65-8c7a-ceb7d97a567b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PaymentsOfOtherEquityInstruments"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_ifrs-full_PaymentsOfOtherEquityInstruments_94a30d96-6fd7-4c65-8c7a-ceb7d97a567b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingOtherEquityInstruments_2d92a0cd-8a9c-48c9-bc3f-b1ff62e6123e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromIssuingOtherEquityInstruments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_ifrs-full_ProceedsFromIssuingOtherEquityInstruments_2d92a0cd-8a9c-48c9-bc3f-b1ff62e6123e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_DividendsPaidOnPreferenceSharesAndOtherEquityInstrumentsClassifiedAsFinancingActivities_c6047e92-da85-46ac-96bc-c4fd9329ab62" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_DividendsPaidOnPreferenceSharesAndOtherEquityInstrumentsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_san_DividendsPaidOnPreferenceSharesAndOtherEquityInstrumentsClassifiedAsFinancingActivities_c6047e92-da85-46ac-96bc-c4fd9329ab62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBondsNotesAndDebentures_194f649e-d26c-4105-97d2-daf47151ac12" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RepaymentsOfBondsNotesAndDebentures"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_ifrs-full_RepaymentsOfBondsNotesAndDebentures_194f649e-d26c-4105-97d2-daf47151ac12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_3c71942f-33ad-4df3-a6c1-793df58ace50" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_3c71942f-33ad-4df3-a6c1-793df58ace50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_240a261d-3462-40d0-8762-9b95a0666376" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_240a261d-3462-40d0-8762-9b95a0666376" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_DividendsPaidOnOrdinarySharesClassifiedAsFinancingActivities_618b302f-738c-4db9-ad71-b9da261b5f91" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#san_DividendsPaidOnOrdinarySharesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_66fdbf79-fdc4-4eca-8bfd-4fea3698fc12" xlink:to="loc_san_DividendsPaidOnOrdinarySharesClassifiedAsFinancingActivities_618b302f-738c-4db9-ad71-b9da261b5f91" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofchangesinequityStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2024-12-31.xsd#StatementofchangesinequityStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofchangesinequityStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_4268d5f3-c5da-4bbe-8317-526e324cc475" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_60667e4b-b592-421e-a632-d7403cbe584a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_4268d5f3-c5da-4bbe-8317-526e324cc475" xlink:to="loc_ifrs-full_ProfitLoss_60667e4b-b592-421e-a632-d7403cbe584a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_74ca8e4c-dcee-4bd2-89b1-94a27f5138d7" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_4268d5f3-c5da-4bbe-8317-526e324cc475" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_74ca8e4c-dcee-4bd2-89b1-94a27f5138d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_b3a4db77-25fb-4b78-8462-0881459a8c4f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_84589871-f66c-444e-b354-7da68bb51589" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_b3a4db77-25fb-4b78-8462-0881459a8c4f" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_84589871-f66c-444e-b354-7da68bb51589" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_f7adf77c-f0dc-4cc1-9986-a6f8a09431de" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_b3a4db77-25fb-4b78-8462-0881459a8c4f" xlink:to="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_f7adf77c-f0dc-4cc1-9986-a6f8a09431de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_ccb862f5-4b9c-4b5e-82fe-3c04bcca0a26" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_b3a4db77-25fb-4b78-8462-0881459a8c4f" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_ccb862f5-4b9c-4b5e-82fe-3c04bcca0a26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_5fca62b3-f631-41d0-b676-bb6a1651506a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_b3a4db77-25fb-4b78-8462-0881459a8c4f" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_5fca62b3-f631-41d0-b676-bb6a1651506a" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
