<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:1614c1ac-6d9d-4b38-85ca-7061c0c3806e,g:11ba0dc2-f380-4bec-8ff4-b22b7878141b-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestRevenueExpense_f2368a3a-0835-46bc-b6b0-f644837f1600" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestRevenueExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestExpense_3cab9ec6-91f9-411c-93bd-928b543e283e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_InterestRevenueExpense_f2368a3a-0835-46bc-b6b0-f644837f1600" xlink:to="loc_ifrs-full_InterestExpense_3cab9ec6-91f9-411c-93bd-928b543e283e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromInterest_7e451d63-ee17-451b-93bb-6bb1fec5f36f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueFromInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_InterestRevenueExpense_f2368a3a-0835-46bc-b6b0-f644837f1600" xlink:to="loc_ifrs-full_RevenueFromInterest_7e451d63-ee17-451b-93bb-6bb1fec5f36f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionIncomeExpense_012f4f84-a6c5-46e5-b589-a4b2647d373d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FeeAndCommissionIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionExpense_954fda14-05c7-4391-96ff-b9dd6dee3256" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FeeAndCommissionExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FeeAndCommissionIncomeExpense_012f4f84-a6c5-46e5-b589-a4b2647d373d" xlink:to="loc_ifrs-full_FeeAndCommissionExpense_954fda14-05c7-4391-96ff-b9dd6dee3256" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionIncome_b0383cfa-fc8a-4988-a058-6c676f298281" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FeeAndCommissionIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FeeAndCommissionIncomeExpense_012f4f84-a6c5-46e5-b589-a4b2647d373d" xlink:to="loc_ifrs-full_FeeAndCommissionIncome_b0383cfa-fc8a-4988-a058-6c676f298281" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_0b9d9181-4b55-489b-a974-af0cc5e69a61" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_ProfitLossFromContinuingOperationsBeforeTax_d541786b-d54c-409b-b105-6610cc35aed9" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_ProfitLossFromContinuingOperationsBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_0b9d9181-4b55-489b-a974-af0cc5e69a61" xlink:to="loc_san_ProfitLossFromContinuingOperationsBeforeTax_d541786b-d54c-409b-b105-6610cc35aed9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_274d01c7-b15a-4554-a185-e2f72581df82" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_0b9d9181-4b55-489b-a974-af0cc5e69a61" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_274d01c7-b15a-4554-a185-e2f72581df82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_beb159a3-7cc2-49b3-8aea-cbea40ab415c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_48d7f9b1-6166-4a38-a86b-6829efd3a716" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_beb159a3-7cc2-49b3-8aea-cbea40ab415c" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_48d7f9b1-6166-4a38-a86b-6829efd3a716" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_47f943e0-402b-47e6-aad5-0cf189eba596" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_beb159a3-7cc2-49b3-8aea-cbea40ab415c" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_47f943e0-402b-47e6-aad5-0cf189eba596" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_ProfitLossFromContinuingOperationsBeforeTax_83f08faf-d44c-4687-b0e9-1b8c225c3b79" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_ProfitLossFromContinuingOperationsBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OperatingExpensesBeforeCreditImpairmentChargesWriteBacksProvisionsAndCharges_64d6aa3d-9091-4ef5-a50d-e0e9c8e99cd1" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_OperatingExpensesBeforeCreditImpairmentChargesWriteBacksProvisionsAndCharges"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_ProfitLossFromContinuingOperationsBeforeTax_83f08faf-d44c-4687-b0e9-1b8c225c3b79" xlink:to="loc_san_OperatingExpensesBeforeCreditImpairmentChargesWriteBacksProvisionsAndCharges_64d6aa3d-9091-4ef5-a50d-e0e9c8e99cd1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueAndOperatingIncome_b96684db-3ac2-4b3e-b25e-6b1bc72ed3ff" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueAndOperatingIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_ProfitLossFromContinuingOperationsBeforeTax_83f08faf-d44c-4687-b0e9-1b8c225c3b79" xlink:to="loc_ifrs-full_RevenueAndOperatingIncome_b96684db-3ac2-4b3e-b25e-6b1bc72ed3ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_f0e9afae-bf9f-40f8-b012-e6786d3a01b0" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_ProfitLossFromContinuingOperationsBeforeTax_83f08faf-d44c-4687-b0e9-1b8c225c3b79" xlink:to="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_f0e9afae-bf9f-40f8-b012-e6786d3a01b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueAndOperatingIncome_836139da-3718-49bd-a14b-14f714840769" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueAndOperatingIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_33e5b725-1f14-4c1b-95ac-7e81ccf546a0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueAndOperatingIncome_836139da-3718-49bd-a14b-14f714840769" xlink:to="loc_ifrs-full_OtherOperatingIncomeExpense_33e5b725-1f14-4c1b-95ac-7e81ccf546a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestRevenueExpense_cf3307b9-51c6-4465-abb9-2874a713c073" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestRevenueExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueAndOperatingIncome_836139da-3718-49bd-a14b-14f714840769" xlink:to="loc_ifrs-full_InterestRevenueExpense_cf3307b9-51c6-4465-abb9-2874a713c073" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FeeAndCommissionIncomeExpense_8e36f02c-a3e2-4a68-bace-28ccec9ea13e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FeeAndCommissionIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueAndOperatingIncome_836139da-3718-49bd-a14b-14f714840769" xlink:to="loc_ifrs-full_FeeAndCommissionIncomeExpense_8e36f02c-a3e2-4a68-bace-28ccec9ea13e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_d5a34047-0d68-4683-bbce-09a05753eb34" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_ProvisionsForOtherLiabilitiesAndCharges_bf94800e-ecf0-4405-acc6-fce1bc61a256" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_ProvisionsForOtherLiabilitiesAndCharges"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_d5a34047-0d68-4683-bbce-09a05753eb34" xlink:to="loc_san_ProvisionsForOtherLiabilitiesAndCharges_bf94800e-ecf0-4405-acc6-fce1bc61a256" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossOnFinancialAssets_b0a43b03-4ecc-4656-ac1d-403a0f9bbd1f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ImpairmentLossOnFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AggregateOperatingCreditImpairmentChargesWriteBacksProvisionsAndCharges_d5a34047-0d68-4683-bbce-09a05753eb34" xlink:to="loc_ifrs-full_ImpairmentLossOnFinancialAssets_b0a43b03-4ecc-4656-ac1d-403a0f9bbd1f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_1bcf22dc-ae06-4ffe-9da4-c41b3695896c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_09564b12-69c1-4d52-8667-4d3fb1506746" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_1bcf22dc-ae06-4ffe-9da4-c41b3695896c" xlink:to="loc_ifrs-full_ProfitLossFromContinuingOperations_09564b12-69c1-4d52-8667-4d3fb1506746" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_0e56a0f0-f637-4520-b889-b655b0af0536" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_1bcf22dc-ae06-4ffe-9da4-c41b3695896c" xlink:to="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_0e56a0f0-f637-4520-b889-b655b0af0536" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_e9deeac1-7281-478a-9ffb-1999c6af4e5a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesBeforeTax_42810218-f35d-4de4-9e3d-67131add0757" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_e9deeac1-7281-478a-9ffb-1999c6af4e5a" xlink:to="loc_ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesBeforeTax_42810218-f35d-4de4-9e3d-67131add0757" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome_35a23d08-97d7-48d9-b7e3-474f183b64d5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_e9deeac1-7281-478a-9ffb-1999c6af4e5a" xlink:to="loc_ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome_35a23d08-97d7-48d9-b7e3-474f183b64d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_b105b5e8-a57e-4a08-b00a-5405a5378be8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_e9deeac1-7281-478a-9ffb-1999c6af4e5a" xlink:to="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_b105b5e8-a57e-4a08-b00a-5405a5378be8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_8f04ea3b-f97b-49a9-889f-3acc0388feb5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_484254dc-3485-4d58-a150-a5df12ec9452" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_8f04ea3b-f97b-49a9-889f-3acc0388feb5" xlink:to="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_484254dc-3485-4d58-a150-a5df12ec9452" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_28406851-0405-4929-902c-39b8f966a38c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_8f04ea3b-f97b-49a9-889f-3acc0388feb5" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_28406851-0405-4929-902c-39b8f966a38c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationNetOfTax_f9b26f19-e74b-4a58-a37b-74d793fd0ce9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_8f04ea3b-f97b-49a9-889f-3acc0388feb5" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationNetOfTax_f9b26f19-e74b-4a58-a37b-74d793fd0ce9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_2264484f-4522-4af9-a0b6-4fbe4a03ab79" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_3ff7a414-3d2b-4f06-a923-9d00e588ea19" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_2264484f-4522-4af9-a0b6-4fbe4a03ab79" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_3ff7a414-3d2b-4f06-a923-9d00e588ea19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_f88c459d-663f-40fe-a53e-3806bbaeef8c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_2264484f-4522-4af9-a0b6-4fbe4a03ab79" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_f88c459d-663f-40fe-a53e-3806bbaeef8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_905d6cbe-fb31-4339-a867-c6e0bd0d1823" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_cd6ac793-3e4a-4859-9f5b-985d0f79ae59" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_905d6cbe-fb31-4339-a867-c6e0bd0d1823" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_cd6ac793-3e4a-4859-9f5b-985d0f79ae59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_74a76571-3e41-4633-b68a-5d7f1ea0028c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_905d6cbe-fb31-4339-a867-c6e0bd0d1823" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_74a76571-3e41-4633-b68a-5d7f1ea0028c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_387e90bf-afed-4509-8962-8bed5295cafb" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_4524cf69-101e-4b07-9778-a788a62f6965" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_387e90bf-afed-4509-8962-8bed5295cafb" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_4524cf69-101e-4b07-9778-a788a62f6965" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_57e898d9-d2be-4cd2-9d27-823a840120ec" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_387e90bf-afed-4509-8962-8bed5295cafb" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_57e898d9-d2be-4cd2-9d27-823a840120ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_15aa5bc6-0a3d-4455-bded-e8971c2d21b8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_57d1b5f5-ab17-4bba-8552-428ef02792e7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_15aa5bc6-0a3d-4455-bded-e8971c2d21b8" xlink:to="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_57d1b5f5-ab17-4bba-8552-428ef02792e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReclassificationAdjustmentsOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_113cba15-407b-4901-8cd5-8e39af447abd" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReclassificationAdjustmentsOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_15aa5bc6-0a3d-4455-bded-e8971c2d21b8" xlink:to="loc_ifrs-full_ReclassificationAdjustmentsOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeBeforeTax_113cba15-407b-4901-8cd5-8e39af447abd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_51f39bb9-782d-476a-8d13-e0b1a99de8d8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxRelatingToFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_15aa5bc6-0a3d-4455-bded-e8971c2d21b8" xlink:to="loc_ifrs-full_IncomeTaxRelatingToFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_51f39bb9-782d-476a-8d13-e0b1a99de8d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_0e88b56e-28b3-4a61-8179-0f998fea403e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToChangesInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiabilityOfOtherComprehensiveIncome_277455dc-7db7-4d13-aee5-34f5a5718b52" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxRelatingToChangesInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiabilityOfOtherComprehensiveIncome"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_0e88b56e-28b3-4a61-8179-0f998fea403e" xlink:to="loc_ifrs-full_IncomeTaxRelatingToChangesInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiabilityOfOtherComprehensiveIncome_277455dc-7db7-4d13-aee5-34f5a5718b52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_09a64a55-09dc-4960-acc3-f77e296ca7bd" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_0e88b56e-28b3-4a61-8179-0f998fea403e" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_09a64a55-09dc-4960-acc3-f77e296ca7bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_d13fa30e-c506-4b25-bf92-870323726a48" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_704def33-646a-4933-bd7e-b7370c47bb88" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_d13fa30e-c506-4b25-bf92-870323726a48" xlink:to="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_704def33-646a-4933-bd7e-b7370c47bb88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_cb5b104e-22ad-43e4-b786-c0c73144ba78" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_d13fa30e-c506-4b25-bf92-870323726a48" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_cb5b104e-22ad-43e4-b786-c0c73144ba78" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_654f3b9a-5890-4637-8782-5693dd612e71" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_a7ddc059-fa39-46a0-b71c-a9d5edb8499c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_654f3b9a-5890-4637-8782-5693dd612e71" xlink:to="loc_ifrs-full_ProfitLoss_a7ddc059-fa39-46a0-b71c-a9d5edb8499c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_fb645702-144d-4452-89f7-7d0470a31168" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_654f3b9a-5890-4637-8782-5693dd612e71" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_fb645702-144d-4452-89f7-7d0470a31168" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofchangesinequityStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#StatementofchangesinequityStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofchangesinequityStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_93d08c96-e8c6-4325-9d6b-4b8a94a84ff0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_bd958c2b-40a1-466a-a5ba-f50ab031b78f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_93d08c96-e8c6-4325-9d6b-4b8a94a84ff0" xlink:to="loc_ifrs-full_ProfitLoss_bd958c2b-40a1-466a-a5ba-f50ab031b78f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_bda21ace-4b9e-4cd4-9643-66565a80c8ac" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_93d08c96-e8c6-4325-9d6b-4b8a94a84ff0" xlink:to="loc_ifrs-full_GainsLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeNetOfTax_bda21ace-4b9e-4cd4-9643-66565a80c8ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_ee437e11-b53b-4264-8fc6-f0545845ec0b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_93d08c96-e8c6-4325-9d6b-4b8a94a84ff0" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_ee437e11-b53b-4264-8fc6-f0545845ec0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_7786d727-aaf7-474a-a1c6-8dc2ff1a2009" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_93d08c96-e8c6-4325-9d6b-4b8a94a84ff0" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_7786d727-aaf7-474a-a1c6-8dc2ff1a2009" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_0c232f93-b1f1-4270-955a-ac015cc2b7b6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_93d08c96-e8c6-4325-9d6b-4b8a94a84ff0" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxChangeInFairValueOfFinancialLiabilityAttributableToChangeInCreditRiskOfLiability_0c232f93-b1f1-4270-955a-ac015cc2b7b6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#StatementoffinancialpositioncurrentnoncurrentStatement"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_cf956ce0-a1db-4e50-a8b3-5678e50346c5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_e026dbf0-84f3-4103-92ad-896b9e805aea" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_cf956ce0-a1db-4e50-a8b3-5678e50346c5" xlink:to="loc_ifrs-full_Equity_e026dbf0-84f3-4103-92ad-896b9e805aea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_65e5928e-1ac0-435b-9708-d031509d4259" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_cf956ce0-a1db-4e50-a8b3-5678e50346c5" xlink:to="loc_ifrs-full_Liabilities_65e5928e-1ac0-435b-9708-d031509d4259" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_0621416a-10d6-48ab-923d-6d82e632be5c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_f843064b-6657-4979-a908-7f3ffcb8fc3f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_0621416a-10d6-48ab-923d-6d82e632be5c" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_f843064b-6657-4979-a908-7f3ffcb8fc3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_69fe9d2c-6304-45cc-bbad-7ee6bb5446e9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_87b86a17-43c9-4dad-9541-baa47b9e9d10" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RetainedEarnings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_69fe9d2c-6304-45cc-bbad-7ee6bb5446e9" xlink:to="loc_ifrs-full_RetainedEarnings_87b86a17-43c9-4dad-9541-baa47b9e9d10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_56187366-9578-46df-a721-b102a7298a3f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SharePremium"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_69fe9d2c-6304-45cc-bbad-7ee6bb5446e9" xlink:to="loc_ifrs-full_SharePremium_56187366-9578-46df-a721-b102a7298a3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_9510109e-5a66-4cb5-bbe1-653413a1386d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_69fe9d2c-6304-45cc-bbad-7ee6bb5446e9" xlink:to="loc_ifrs-full_IssuedCapital_9510109e-5a66-4cb5-bbe1-653413a1386d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_33f4a738-75f6-48b3-81b6-7f39980ce744" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_69fe9d2c-6304-45cc-bbad-7ee6bb5446e9" xlink:to="loc_ifrs-full_OtherReserves_33f4a738-75f6-48b3-81b6-7f39980ce744" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherEquityInterest_4d1982f5-a96d-4520-b395-cb227b2bd660" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherEquityInterest"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_69fe9d2c-6304-45cc-bbad-7ee6bb5446e9" xlink:to="loc_ifrs-full_OtherEquityInterest_4d1982f5-a96d-4520-b395-cb227b2bd660" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_MacroHedgeOfInterestRateRiskAsset_706c8710-20f3-4295-a544-8009b80e27a6" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_MacroHedgeOfInterestRateRiskAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_san_MacroHedgeOfInterestRateRiskAsset_706c8710-20f3-4295-a544-8009b80e27a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RecognisedAssetsDefinedBenefitPlan_6fe113eb-9f60-4fc2-a77a-bd8fc38f6864" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RecognisedAssetsDefinedBenefitPlan"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_RecognisedAssetsDefinedBenefitPlan_6fe113eb-9f60-4fc2-a77a-bd8fc38f6864" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsAndGoodwill_e57bec6a-85d5-44a3-8442-ebf63397c28a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IntangibleAssetsAndGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_IntangibleAssetsAndGoodwill_e57bec6a-85d5-44a3-8442-ebf63397c28a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherFinancialAssetsAtFairValueThroughProfitOrLoss_fb7bc3b7-b988-4c36-b9da-0f7dfb3b077e" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_OtherFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_san_OtherFinancialAssetsAtFairValueThroughProfitOrLoss_fb7bc3b7-b988-4c36-b9da-0f7dfb3b077e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssets_a610be2a-dec4-4107-b727-9b92225d280c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_CurrentTaxAssets_a610be2a-dec4-4107-b727-9b92225d280c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_3830339e-f5e9-4e2e-af52-edca72d310f8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_ReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_3830339e-f5e9-4e2e-af52-edca72d310f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndBankBalancesAtCentralBanks_27a5a2ce-956e-4774-b157-2807f27537b6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndBankBalancesAtCentralBanks"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_CashAndBankBalancesAtCentralBanks_27a5a2ce-956e-4774-b157-2807f27537b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialAssetsAtFairValueThroughOtherComprehensiveIncome_c6bfe56c-433a-4cce-a290-3e144ed48c5d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialAssetsAtFairValueThroughOtherComprehensiveIncome"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_FinancialAssetsAtFairValueThroughOtherComprehensiveIncome_c6bfe56c-433a-4cce-a290-3e144ed48c5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherFinancialAssetsAtAmortisedCost_4d521fa6-3f80-46a7-9bd0-15d1fd40f99b" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_OtherFinancialAssetsAtAmortisedCost"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_san_OtherFinancialAssetsAtAmortisedCost_4d521fa6-3f80-46a7-9bd0-15d1fd40f99b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_f9480a22-80ad-42e6-80c7-e773eeee1dcf" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_f9480a22-80ad-42e6-80c7-e773eeee1dcf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialAssets_0313e769-cb63-4992-8010-9a5ea0f35269" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DerivativeFinancialAssets"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_DerivativeFinancialAssets_0313e769-cb63-4992-8010-9a5ea0f35269" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_b6a6ff9e-2294-43ee-9f06-87775d7a2228" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_b6a6ff9e-2294-43ee-9f06-87775d7a2228" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentsInJointVenturesAccountedForUsingEquityMethod_5fb0ae89-05f3-4705-8ecb-e51ea052272d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InvestmentsInJointVenturesAccountedForUsingEquityMethod"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_InvestmentsInJointVenturesAccountedForUsingEquityMethod_5fb0ae89-05f3-4705-8ecb-e51ea052272d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LoansAndAdvancesToCustomers_b123a958-b081-45d8-9b43-70319bd130dd" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LoansAndAdvancesToCustomers"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_LoansAndAdvancesToCustomers_b123a958-b081-45d8-9b43-70319bd130dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAssets_3c06a9d4-610c-4eba-b7fd-7344a2d120c6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherAssets"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_OtherAssets_3c06a9d4-610c-4eba-b7fd-7344a2d120c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LoansAndAdvancesToBanks_99b60184-a589-40ec-be29-4949c2af9144" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LoansAndAdvancesToBanks"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_8431c36f-8983-46d9-a882-f464e13e5523" xlink:to="loc_ifrs-full_LoansAndAdvancesToBanks_99b60184-a589-40ec-be29-4949c2af9144" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_MacroHedgeOfInterestRateRiskLiability_a3faa969-81d5-4774-94aa-ec2117663a54" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_MacroHedgeOfInterestRateRiskLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_san_MacroHedgeOfInterestRateRiskLiability_a3faa969-81d5-4774-94aa-ec2117663a54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DebtSecurities_14bccb3a-4330-4d9d-a069-301d8e854920" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_DebtSecurities_14bccb3a-4330-4d9d-a069-301d8e854920" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_8a830ea7-44f6-4009-a858-913df316d157" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_OtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_san_OtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_8a830ea7-44f6-4009-a858-913df316d157" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Provisions_4f85fb5e-2102-48da-a706-51a4816a536b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Provisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_Provisions_4f85fb5e-2102-48da-a706-51a4816a536b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RecognisedLiabilitiesDefinedBenefitPlan_e8c9538d-acdc-4912-9d39-17d51fc1a74e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RecognisedLiabilitiesDefinedBenefitPlan"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_RecognisedLiabilitiesDefinedBenefitPlan_e8c9538d-acdc-4912-9d39-17d51fc1a74e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepurchaseAgreementsAndCashCollateralOnSecuritiesLent_0b920b6c-b7a6-4566-b3a8-801e8a8993a7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RepurchaseAgreementsAndCashCollateralOnSecuritiesLent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_RepurchaseAgreementsAndCashCollateralOnSecuritiesLent_0b920b6c-b7a6-4566-b3a8-801e8a8993a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepositsFromCustomers_2f4bbec9-f828-4b46-9656-2ba0a515f401" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DepositsFromCustomers"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_DepositsFromCustomers_2f4bbec9-f828-4b46-9656-2ba0a515f401" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DerivativeFinancialLiabilities_43726e73-3c38-4e59-b6ce-21d550a866c3" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DerivativeFinancialLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_DerivativeFinancialLiabilities_43726e73-3c38-4e59-b6ce-21d550a866c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetDeferredTaxLiabilities_b17ef55b-d011-4391-bc06-3127babb4bb9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NetDeferredTaxLiabilities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_NetDeferredTaxLiabilities_b17ef55b-d011-4391-bc06-3127babb4bb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SubordinatedLiabilities_78cb89cf-b687-40d5-9fc5-202a5104366a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SubordinatedLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_SubordinatedLiabilities_78cb89cf-b687-40d5-9fc5-202a5104366a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DepositsFromBanks_d2735548-c389-4b89-a902-9e23d8225495" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DepositsFromBanks"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_DepositsFromBanks_d2735548-c389-4b89-a902-9e23d8225495" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherLiabilities_9cf602fe-1750-430d-8d97-15f74be234fb" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_02e27973-71a4-4e85-98d6-744172424792" xlink:to="loc_ifrs-full_OtherLiabilities_9cf602fe-1750-430d-8d97-15f74be234fb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://santander.co.uk/role/StatementofcashflowsindirectmethodDetails" xlink:type="simple" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#StatementofcashflowsindirectmethodDetails"/>
  <link:calculationLink xlink:role="http://santander.co.uk/role/StatementofcashflowsindirectmethodDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_4c638c31-68f6-493e-8237-cb43c575adc7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_0c7cb751-3ebc-4dad-b642-8f6308bfb2d8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_4c638c31-68f6-493e-8237-cb43c575adc7" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_0c7cb751-3ebc-4dad-b642-8f6308bfb2d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_4a981fd8-f693-4b8b-8424-27a0d0e36284" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_4c638c31-68f6-493e-8237-cb43c575adc7" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_4a981fd8-f693-4b8b-8424-27a0d0e36284" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_cbcffd34-458a-44ed-b2d7-3f1d2e86ad55" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_4c638c31-68f6-493e-8237-cb43c575adc7" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_cbcffd34-458a-44ed-b2d7-3f1d2e86ad55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_b454baf1-7242-4a8c-bf66-cc5aee789ff5" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BankBalancesAtCentralBanksOtherThanMandatoryReserveDeposits_9b7f0d24-d4fd-4f56-9ad2-f23ccd64d89d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_BankBalancesAtCentralBanksOtherThanMandatoryReserveDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_b454baf1-7242-4a8c-bf66-cc5aee789ff5" xlink:to="loc_ifrs-full_BankBalancesAtCentralBanksOtherThanMandatoryReserveDeposits_9b7f0d24-d4fd-4f56-9ad2-f23ccd64d89d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherCashEquivalentsLoansAndAdvancesToBanksNonTrading_2c74d056-6c27-4b09-bb8e-80684c55d874" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_OtherCashEquivalentsLoansAndAdvancesToBanksNonTrading"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_b454baf1-7242-4a8c-bf66-cc5aee789ff5" xlink:to="loc_san_OtherCashEquivalentsLoansAndAdvancesToBanksNonTrading_2c74d056-6c27-4b09-bb8e-80684c55d874" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_OtherCashEquivalentsReverseRepurchaseAgreements_1dc94410-bd2f-4e06-bedd-0a6a2dd84d1a" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_OtherCashEquivalentsReverseRepurchaseAgreements"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalents_b454baf1-7242-4a8c-bf66-cc5aee789ff5" xlink:to="loc_san_OtherCashEquivalentsReverseRepurchaseAgreements_1dc94410-bd2f-4e06-bedd-0a6a2dd84d1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_9d94db09-3086-45a6-aa4e-df26d4b307ee" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_88a873b3-b5cb-4039-80ee-34e61cd62b7e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_9d94db09-3086-45a6-aa4e-df26d4b307ee" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_88a873b3-b5cb-4039-80ee-34e61cd62b7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_eedc9269-eb30-4df9-9264-81408a0581b4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_9d94db09-3086-45a6-aa4e-df26d4b307ee" xlink:to="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_eedc9269-eb30-4df9-9264-81408a0581b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_4865ab50-92b7-4a24-8730-a237c8a91941" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_9d94db09-3086-45a6-aa4e-df26d4b307ee" xlink:to="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_4865ab50-92b7-4a24-8730-a237c8a91941" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_1187ce85-8360-457c-9db2-2d881f8c9fa2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_9d94db09-3086-45a6-aa4e-df26d4b307ee" xlink:to="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_1187ce85-8360-457c-9db2-2d881f8c9fa2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInOtherFinancialAssetsAtFairValueThroughProfitOrLoss_e75c8913-4509-415e-8bb9-4d43862e54c7" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInOtherFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInOtherFinancialAssetsAtFairValueThroughProfitOrLoss_e75c8913-4509-415e-8bb9-4d43862e54c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets_442c40fc-b4c1-4fe9-89b6-e75b70f752eb" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets_442c40fc-b4c1-4fe9-89b6-e75b70f752eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInCashAndBalancesAtCentralBanks_5d25ed54-f504-4694-ab58-be737b641dac" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInCashAndBalancesAtCentralBanks"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInCashAndBalancesAtCentralBanks_5d25ed54-f504-4694-ab58-be737b641dac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_0d3115c8-d8d8-40c5-aa1e-61163fc1b846" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInReverseRepurchaseAgreementsAndCashCollateralOnSecuritiesBorrowed_0d3115c8-d8d8-40c5-aa1e-61163fc1b846" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities_86dea248-d9d3-4cc5-baa7-beb41a951e74" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities_86dea248-d9d3-4cc5-baa7-beb41a951e74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForIncreaseDecreaseInDepositsFromBanksAndCustomers_13782702-9d25-474e-bad1-8efb506f460d" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForIncreaseDecreaseInDepositsFromBanksAndCustomers"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_san_AdjustmentsForIncreaseDecreaseInDepositsFromBanksAndCustomers_13782702-9d25-474e-bad1-8efb506f460d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForIncreaseDecreaseInDebtSecuritiesInIssue_058e6701-a8f3-4b16-ba05-0e088bf33993" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForIncreaseDecreaseInDebtSecuritiesInIssue"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_san_AdjustmentsForIncreaseDecreaseInDebtSecuritiesInIssue_058e6701-a8f3-4b16-ba05-0e088bf33993" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInDerivativeFinancialAssets_e5a71b6e-c6a6-48e6-8dbc-3e83efa96679" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInDerivativeFinancialAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInDerivativeFinancialAssets_e5a71b6e-c6a6-48e6-8dbc-3e83efa96679" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInRepurchaseAgreementsAndCashCollateralOnSecuritiesLent_a110f220-b02a-4018-8ead-dae6128b55c6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInRepurchaseAgreementsAndCashCollateralOnSecuritiesLent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInRepurchaseAgreementsAndCashCollateralOnSecuritiesLent_a110f220-b02a-4018-8ead-dae6128b55c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInLoansAndAdvancesToBanksAndCustomers_507ccfbc-c579-4f6a-8fe0-bb1a32115166" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInLoansAndAdvancesToBanksAndCustomers"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInLoansAndAdvancesToBanksAndCustomers_507ccfbc-c579-4f6a-8fe0-bb1a32115166" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForIncreaseDecreaseInOtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_0abe6a12-7bc3-4765-a67e-b027591eb7dd" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForIncreaseDecreaseInOtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_san_AdjustmentsForIncreaseDecreaseInOtherFinancialLiabilitiesAtFairValueThroughProfitOrLoss_0abe6a12-7bc3-4765-a67e-b027591eb7dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities_e9dad944-9ebe-456e-a89c-74e7960777fc" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_039251a0-cb2e-4779-820e-977bab4a60be" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDerivativeFinancialLiabilities_e9dad944-9ebe-456e-a89c-74e7960777fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingOtherEquityInstruments_15556c7b-a5db-4163-b098-b66039112140" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromIssuingOtherEquityInstruments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_ifrs-full_ProceedsFromIssuingOtherEquityInstruments_15556c7b-a5db-4163-b098-b66039112140" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_DisposalOfNonControllingInterests_9ed8e9c9-82d4-47ea-8c0a-1d845adcefa7" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_DisposalOfNonControllingInterests"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_san_DisposalOfNonControllingInterests_9ed8e9c9-82d4-47ea-8c0a-1d845adcefa7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsForDebtIssueCosts_b7338eb8-5ae4-409c-9e13-23fc92e8508c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PaymentsForDebtIssueCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_ifrs-full_PaymentsForDebtIssueCosts_b7338eb8-5ae4-409c-9e13-23fc92e8508c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_f83ca1b8-8e48-493e-bbb9-61420ec7fe9e" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_f83ca1b8-8e48-493e-bbb9-61420ec7fe9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_DividendsPaidOnPreferenceSharesAndOtherEquityInstrumentsClassifiedAsFinancingActivities_83749ddd-c30f-4cc2-b38e-611bbaca2fe2" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_DividendsPaidOnPreferenceSharesAndOtherEquityInstrumentsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_san_DividendsPaidOnPreferenceSharesAndOtherEquityInstrumentsClassifiedAsFinancingActivities_83749ddd-c30f-4cc2-b38e-611bbaca2fe2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_CashFlowsFromUsedInDisposalOfNonControllingInterests_3dd098e5-1490-44ef-9fa3-ef1a1a9485ec" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_CashFlowsFromUsedInDisposalOfNonControllingInterests"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_san_CashFlowsFromUsedInDisposalOfNonControllingInterests_3dd098e5-1490-44ef-9fa3-ef1a1a9485ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_DividendsPaidOnOrdinarySharesClassifiedAsFinancingActivities_ca84ac2a-32a4-40cd-afb5-ca59d859f082" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_DividendsPaidOnOrdinarySharesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_san_DividendsPaidOnOrdinarySharesClassifiedAsFinancingActivities_ca84ac2a-32a4-40cd-afb5-ca59d859f082" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_e06329b1-0c32-48b6-b88a-0e5269979a39" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_e06329b1-0c32-48b6-b88a-0e5269979a39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBondsNotesAndDebentures_96ee2eea-e89b-492f-bc94-5000c3a12708" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RepaymentsOfBondsNotesAndDebentures"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_ifrs-full_RepaymentsOfBondsNotesAndDebentures_96ee2eea-e89b-492f-bc94-5000c3a12708" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities_9d1bab1b-45c3-4ad2-ad53-4b580704d7ff" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities_9d1bab1b-45c3-4ad2-ad53-4b580704d7ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfOtherEquityInstruments_273f2d9a-5fad-4cf2-8478-30bf93d92ff6" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PaymentsOfOtherEquityInstruments"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_731a56ca-c4dc-4ff5-951f-86d3f075a40a" xlink:to="loc_ifrs-full_PaymentsOfOtherEquityInstruments_273f2d9a-5fad-4cf2-8478-30bf93d92ff6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96f7f4a1-0f27-486d-931a-8c08acdb819b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_5699b864-be2c-4f0f-95a0-3fd73f19b09d" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96f7f4a1-0f27-486d-931a-8c08acdb819b" xlink:to="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_5699b864-be2c-4f0f-95a0-3fd73f19b09d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_1930c078-73d1-4e6d-80bc-09e970cea0f8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96f7f4a1-0f27-486d-931a-8c08acdb819b" xlink:to="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_1930c078-73d1-4e6d-80bc-09e970cea0f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_c9d1f5ff-9c5b-4d69-9745-e1c7f8f334ad" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96f7f4a1-0f27-486d-931a-8c08acdb819b" xlink:to="loc_ifrs-full_IncomeTaxesPaidClassifiedAsOperatingActivities_c9d1f5ff-9c5b-4d69-9745-e1c7f8f334ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_7dd08cc9-e754-4451-8f10-2f6d51003491" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96f7f4a1-0f27-486d-931a-8c08acdb819b" xlink:to="loc_san_AdjustmentsForDecreaseIncreaseInOperatingAssetsAndLiabilities_7dd08cc9-e754-4451-8f10-2f6d51003491" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_66a89f6e-7d84-4d25-ad4f-6514b9ed079b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_96f7f4a1-0f27-486d-931a-8c08acdb819b" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_66a89f6e-7d84-4d25-ad4f-6514b9ed079b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e1fc5eec-a12d-49c6-9a0a-4af7c65d2845" xlink:href="PTCQB104N23FMNK2RZ28-2022-12-31.xsd#san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_aebf4bea-8d03-43c9-a61e-6c26233a5c11" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e1fc5eec-a12d-49c6-9a0a-4af7c65d2845" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_aebf4bea-8d03-43c9-a61e-6c26233a5c11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_d89702d0-12c6-4fb7-bc07-64c5c87c9029" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e1fc5eec-a12d-49c6-9a0a-4af7c65d2845" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_d89702d0-12c6-4fb7-bc07-64c5c87c9029" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_8b76e8c4-eacd-4e3b-b166-ab87c68211c7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e1fc5eec-a12d-49c6-9a0a-4af7c65d2845" xlink:to="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_8b76e8c4-eacd-4e3b-b166-ab87c68211c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForProvisions_336fe721-0774-476d-af63-439e5d10b42f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForProvisions"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e1fc5eec-a12d-49c6-9a0a-4af7c65d2845" xlink:to="loc_ifrs-full_AdjustmentsForProvisions_336fe721-0774-476d-af63-439e5d10b42f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_27f8d447-ee17-46ec-b660-3ec79664fbcf" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_san_AdjustmentsToReconcileProfitLossToNetCashFlowFromUsedInOperatingActivitiesBeforeAdjustmentsForChangesInOperatingAssetsAndLiabilities_e1fc5eec-a12d-49c6-9a0a-4af7c65d2845" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_27f8d447-ee17-46ec-b660-3ec79664fbcf" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
