<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:0f1b1c4b-c4e9-484f-8c59-5fe0be10e3a3,g:ef0f12f4-340a-4abd-b35f-55712fbeebf1-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.innate-pharma.com/role/tatdelasituationfinancirecourantnoncourant" xlink:type="simple" xlink:href="inph-2021-12-31.xsd#tatdelasituationfinancirecourantnoncourant"/>
  <link:calculationLink xlink:role="http://www.innate-pharma.com/role/tatdelasituationfinancirecourantnoncourant" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_d353440e-2222-4078-952d-b008a69d226f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_54cc6a2e-740c-4c30-b54f-b448540947c9" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_d353440e-2222-4078-952d-b008a69d226f" xlink:to="loc_ifrs-full_CurrentAssets_54cc6a2e-740c-4c30-b54f-b448540947c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_fdc29530-ee71-4613-a5aa-2af126387dbc" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_d353440e-2222-4078-952d-b008a69d226f" xlink:to="loc_ifrs-full_NoncurrentAssets_fdc29530-ee71-4613-a5aa-2af126387dbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_4253798e-e4ff-455d-80b6-ddbfa92fb1b7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilities_c7d568d9-4280-49d9-8ebf-790ded48f958" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentFinancialLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_4253798e-e4ff-455d-80b6-ddbfa92fb1b7" xlink:to="loc_ifrs-full_CurrentFinancialLiabilities_c7d568d9-4280-49d9-8ebf-790ded48f958" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_bbfdf014-6b5b-41d5-9f35-5d071338b531" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_4253798e-e4ff-455d-80b6-ddbfa92fb1b7" xlink:to="loc_ifrs-full_CurrentProvisions_bbfdf014-6b5b-41d5-9f35-5d071338b531" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_9d6d3dad-f404-498d-952b-c36cafc6b8c6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_4253798e-e4ff-455d-80b6-ddbfa92fb1b7" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_9d6d3dad-f404-498d-952b-c36cafc6b8c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredIncomeClassifiedAsCurrent_09c46ea4-c90c-477a-890b-09b7bbba2d91" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_DeferredIncomeClassifiedAsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_4253798e-e4ff-455d-80b6-ddbfa92fb1b7" xlink:to="loc_ifrs-full_DeferredIncomeClassifiedAsCurrent_09c46ea4-c90c-477a-890b-09b7bbba2d91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_DettesSurCollaborationCourantes_cfecf7f7-1f2b-402b-ba47-4b31a98139de" xlink:href="inph-2021-12-31.xsd#inph_DettesSurCollaborationCourantes"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_4253798e-e4ff-455d-80b6-ddbfa92fb1b7" xlink:to="loc_inph_DettesSurCollaborationCourantes_cfecf7f7-1f2b-402b-ba47-4b31a98139de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_83d52cfa-ffe3-4a9e-941c-5c2f70aeab2e" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialAssets_1fd42047-2d17-4bc9-8d42-4ce72a7c9ab2" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentFinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_83d52cfa-ffe3-4a9e-941c-5c2f70aeab2e" xlink:to="loc_ifrs-full_CurrentFinancialAssets_1fd42047-2d17-4bc9-8d42-4ce72a7c9ab2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_92023c42-c272-406a-b63c-2251c54fb6cd" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_83d52cfa-ffe3-4a9e-941c-5c2f70aeab2e" xlink:to="loc_ifrs-full_CashAndCashEquivalents_92023c42-c272-406a-b63c-2251c54fb6cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_ad2dda39-b2b9-4219-8334-bce95584b694" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_83d52cfa-ffe3-4a9e-941c-5c2f70aeab2e" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_ad2dda39-b2b9-4219-8334-bce95584b694" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_7c655c3c-38e6-427f-afc4-fd4d450e7a27" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_f41b7544-d855-4022-a965-b677e7d9dd8a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_7c655c3c-38e6-427f-afc4-fd4d450e7a27" xlink:to="loc_ifrs-full_NoncurrentLiabilities_f41b7544-d855-4022-a965-b677e7d9dd8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_9cdbfb77-dd87-4266-971b-46a98e2b1c0f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_7c655c3c-38e6-427f-afc4-fd4d450e7a27" xlink:to="loc_ifrs-full_Equity_9cdbfb77-dd87-4266-971b-46a98e2b1c0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_3191e74e-3885-4370-87a3-ed22103c0017" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_7c655c3c-38e6-427f-afc4-fd4d450e7a27" xlink:to="loc_ifrs-full_CurrentLiabilities_3191e74e-3885-4370-87a3-ed22103c0017" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_1333c355-f60b-4ead-845c-2a5b6ed182fa" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredIncomeClassifiedAsNoncurrent_3a719b19-dfd4-44ec-8237-99838f729e36" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_DeferredIncomeClassifiedAsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_1333c355-f60b-4ead-845c-2a5b6ed182fa" xlink:to="loc_ifrs-full_DeferredIncomeClassifiedAsNoncurrent_3a719b19-dfd4-44ec-8237-99838f729e36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilities_0ef6d38c-da64-49b4-87de-b0342df9d4b2" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentFinancialLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_1333c355-f60b-4ead-845c-2a5b6ed182fa" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilities_0ef6d38c-da64-49b4-87de-b0342df9d4b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_4832b1d1-46bd-4fc3-9cac-df99f31e18d0" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_1333c355-f60b-4ead-845c-2a5b6ed182fa" xlink:to="loc_ifrs-full_NoncurrentProvisions_4832b1d1-46bd-4fc3-9cac-df99f31e18d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_e0c9939e-da3b-42f7-a1b2-f3c282b5f1e7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentProvisionsForEmployeeBenefits"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_1333c355-f60b-4ead-845c-2a5b6ed182fa" xlink:to="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_e0c9939e-da3b-42f7-a1b2-f3c282b5f1e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_d5dd5b3c-d741-4910-99fa-46c92ecd81b7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_1333c355-f60b-4ead-845c-2a5b6ed182fa" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_d5dd5b3c-d741-4910-99fa-46c92ecd81b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_DettesSurCollaborationNonCourantes_18989eea-593a-469e-badd-327fb2419a40" xlink:href="inph-2021-12-31.xsd#inph_DettesSurCollaborationNonCourantes"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_1333c355-f60b-4ead-845c-2a5b6ed182fa" xlink:to="loc_inph_DettesSurCollaborationNonCourantes_18989eea-593a-469e-badd-327fb2419a40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_6f676c23-6351-4baa-8cba-e8c3d111df31" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_cbb9f5dc-f42e-471e-b80c-816b885bfdcf" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_6f676c23-6351-4baa-8cba-e8c3d111df31" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_cbb9f5dc-f42e-471e-b80c-816b885bfdcf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssets_854ba905-5384-43d6-a3d4-a44ba7c39910" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentFinancialAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_6f676c23-6351-4baa-8cba-e8c3d111df31" xlink:to="loc_ifrs-full_NoncurrentFinancialAssets_854ba905-5384-43d6-a3d4-a44ba7c39910" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_d6b66ce3-6678-482c-8e7c-e683529135cb" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_6f676c23-6351-4baa-8cba-e8c3d111df31" xlink:to="loc_ifrs-full_DeferredTaxAssets_d6b66ce3-6678-482c-8e7c-e683529135cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentReceivables_99ec1af7-6179-40db-b310-0cf971f98fa6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentReceivables"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_6f676c23-6351-4baa-8cba-e8c3d111df31" xlink:to="loc_ifrs-full_NoncurrentReceivables_99ec1af7-6179-40db-b310-0cf971f98fa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_35c98387-46ac-4ff0-bd54-0e807de541c1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_6f676c23-6351-4baa-8cba-e8c3d111df31" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_35c98387-46ac-4ff0-bd54-0e807de541c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_83cb6adf-682f-4afe-9d78-b1f07cdb3d1b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherNoncurrentNonfinancialAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_6f676c23-6351-4baa-8cba-e8c3d111df31" xlink:to="loc_ifrs-full_OtherNoncurrentNonfinancialAssets_83cb6adf-682f-4afe-9d78-b1f07cdb3d1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_6458b294-75a6-435d-843b-a1d274088dc2" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_dc4792de-9be6-41df-bc69-b0a1726b0bde" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_6458b294-75a6-435d-843b-a1d274088dc2" xlink:to="loc_ifrs-full_IssuedCapital_dc4792de-9be6-41df-bc69-b0a1726b0bde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_91cfe563-2538-46c7-9181-1cd0385dc395" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_SharePremium"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_6458b294-75a6-435d-843b-a1d274088dc2" xlink:to="loc_ifrs-full_SharePremium_91cfe563-2538-46c7-9181-1cd0385dc395" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_ReservesEtReportANouveau_2aa8f788-325b-49f6-acc0-8d1e87c0816e" xlink:href="inph-2021-12-31.xsd#inph_ReservesEtReportANouveau"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_6458b294-75a6-435d-843b-a1d274088dc2" xlink:to="loc_inph_ReservesEtReportANouveau_2aa8f788-325b-49f6-acc0-8d1e87c0816e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_ResultatDeLExercice_34f307ca-1704-4584-aa82-45ca5443bd79" xlink:href="inph-2021-12-31.xsd#inph_ResultatDeLExercice"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_6458b294-75a6-435d-843b-a1d274088dc2" xlink:to="loc_inph_ResultatDeLExercice_34f307ca-1704-4584-aa82-45ca5443bd79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_9fa46bb3-2e47-45fe-821e-0bc97fcd249b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_6458b294-75a6-435d-843b-a1d274088dc2" xlink:to="loc_ifrs-full_OtherReserves_9fa46bb3-2e47-45fe-821e-0bc97fcd249b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.innate-pharma.com/role/tatdursultatglobalrsultatnetchargesparfonction" xlink:type="simple" xlink:href="inph-2021-12-31.xsd#tatdursultatglobalrsultatnetchargesparfonction"/>
  <link:calculationLink xlink:role="http://www.innate-pharma.com/role/tatdursultatglobalrsultatnetchargesparfonction" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_8d549522-3f79-4a05-be3e-bcde643337d2" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_1de796e7-68cc-4288-ac1f-dcb1b8fd01d3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OperatingExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_8d549522-3f79-4a05-be3e-bcde643337d2" xlink:to="loc_ifrs-full_OperatingExpense_1de796e7-68cc-4288-ac1f-dcb1b8fd01d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_c5b60242-fb58-478c-a365-c53110e4ec8d" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Revenue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_8d549522-3f79-4a05-be3e-bcde643337d2" xlink:to="loc_ifrs-full_Revenue_c5b60242-fb58-478c-a365-c53110e4ec8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_c4ccc119-e6e7-4dfa-9858-333f697c4ccb" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_69628b2c-f516-4903-9388-28b6598672f6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_c4ccc119-e6e7-4dfa-9858-333f697c4ccb" xlink:to="loc_ifrs-full_FinanceCosts_69628b2c-f516-4903-9388-28b6598672f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_cca0b170-2f68-4223-838e-5e92da04c4f2" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_c4ccc119-e6e7-4dfa-9858-333f697c4ccb" xlink:to="loc_ifrs-full_FinanceIncome_cca0b170-2f68-4223-838e-5e92da04c4f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_b52cd488-dfea-49bc-a5ef-5ad08b4b98f6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OperatingExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_5d02673c-030c-4ad0-bf29-dd09c1c46120" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_b52cd488-dfea-49bc-a5ef-5ad08b4b98f6" xlink:to="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_5d02673c-030c-4ad0-bf29-dd09c1c46120" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_b98bca02-9f2e-4774-a874-a17cb3e1b981" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OperatingExpense_b52cd488-dfea-49bc-a5ef-5ad08b4b98f6" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_b98bca02-9f2e-4774-a874-a17cb3e1b981" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_e96a8881-beca-4134-9d7f-dbca4bc51a65" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_16ebc251-2ebd-4ecc-b713-51ba2933e06e" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_e96a8881-beca-4134-9d7f-dbca4bc51a65" xlink:to="loc_ifrs-full_FinanceIncomeCost_16ebc251-2ebd-4ecc-b713-51ba2933e06e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_4dea12a2-6f2f-43fb-b12e-c6b4acda21c1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_e96a8881-beca-4134-9d7f-dbca4bc51a65" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_4dea12a2-6f2f-43fb-b12e-c6b4acda21c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_0fdd945b-4721-47df-8c4c-571ceee0788f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_66e4ced3-0b8a-48d3-92b0-36cf1af96776" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_0fdd945b-4721-47df-8c4c-571ceee0788f" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_66e4ced3-0b8a-48d3-92b0-36cf1af96776" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_4306b4d9-d3d6-45d9-873e-7acf31632e34" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_0fdd945b-4721-47df-8c4c-571ceee0788f" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_4306b4d9-d3d6-45d9-873e-7acf31632e34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_e78df086-3c61-44b8-92c2-fa80dce28a43" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_ab365c45-8ee5-48c4-825b-09e30c2bca24" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_e78df086-3c61-44b8-92c2-fa80dce28a43" xlink:to="loc_ifrs-full_ProfitLossFromContinuingOperations_ab365c45-8ee5-48c4-825b-09e30c2bca24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_ca5fa2de-56b6-4947-a554-320d7269c584" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossFromDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_e78df086-3c61-44b8-92c2-fa80dce28a43" xlink:to="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_ca5fa2de-56b6-4947-a554-320d7269c584" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_50fa996a-eb37-452e-b605-5893bc80f3a1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Revenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromGovernmentGrants_51725cc1-4782-4bfc-9b35-2c2ed95d9657" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RevenueFromGovernmentGrants"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Revenue_50fa996a-eb37-452e-b605-5893bc80f3a1" xlink:to="loc_ifrs-full_RevenueFromGovernmentGrants_51725cc1-4782-4bfc-9b35-2c2ed95d9657" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_74ed3691-1f65-40aa-8e20-6e1d12a13aaf" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Revenue_50fa996a-eb37-452e-b605-5893bc80f3a1" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_74ed3691-1f65-40aa-8e20-6e1d12a13aaf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.innate-pharma.com/role/tatdursultatglobalcomposantesdesautreslmentsdursultatglobalprsentesnettesdimpt" xlink:type="simple" xlink:href="inph-2021-12-31.xsd#tatdursultatglobalcomposantesdesautreslmentsdursultatglobalprsentesnettesdimpt"/>
  <link:calculationLink xlink:role="http://www.innate-pharma.com/role/tatdursultatglobalcomposantesdesautreslmentsdursultatglobalprsentesnettesdimpt" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_7a4b541b-cc92-4149-8b05-5cce6ca07d89" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_f68e52ed-47f7-4ab7-8256-8cfabd82482f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_7a4b541b-cc92-4149-8b05-5cce6ca07d89" xlink:to="loc_ifrs-full_ProfitLoss_f68e52ed-47f7-4ab7-8256-8cfabd82482f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_e5b34a6a-ec15-4479-b226-18170939fa11" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_7a4b541b-cc92-4149-8b05-5cce6ca07d89" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_e5b34a6a-ec15-4479-b226-18170939fa11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_7be16bd6-cbb5-445e-af76-6607dad55fc7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_48e4cc37-c724-4433-952c-39443c900969" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_7be16bd6-cbb5-445e-af76-6607dad55fc7" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_48e4cc37-c724-4433-952c-39443c900969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_32247165-26a0-4834-a458-ff1e709af71f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_7be16bd6-cbb5-445e-af76-6607dad55fc7" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_32247165-26a0-4834-a458-ff1e709af71f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_f426abb7-16c1-4f8e-b768-fd6c3ecaac1b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_7be16bd6-cbb5-445e-af76-6607dad55fc7" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_f426abb7-16c1-4f8e-b768-fd6c3ecaac1b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.innate-pharma.com/role/tatdesfluxdetrsoreriemthodeindirecte" xlink:type="simple" xlink:href="inph-2021-12-31.xsd#tatdesfluxdetrsoreriemthodeindirecte"/>
  <link:calculationLink xlink:role="http://www.innate-pharma.com/role/tatdesfluxdetrsoreriemthodeindirecte" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_inph_BesoinEnFondsDeRoulement_f15317f3-89c4-4f6a-9e0e-df73eb450287" xlink:href="inph-2021-12-31.xsd#inph_BesoinEnFondsDeRoulement"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherPayables_e367cb59-6db2-416a-befe-c4a4178cdbaf" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_TradeAndOtherPayables"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_inph_BesoinEnFondsDeRoulement_f15317f3-89c4-4f6a-9e0e-df73eb450287" xlink:to="loc_ifrs-full_TradeAndOtherPayables_e367cb59-6db2-416a-befe-c4a4178cdbaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherReceivables_3d554e8a-8add-4e93-98c1-e3866f1d9a2d" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_TradeAndOtherReceivables"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_inph_BesoinEnFondsDeRoulement_f15317f3-89c4-4f6a-9e0e-df73eb450287" xlink:to="loc_ifrs-full_TradeAndOtherReceivables_3d554e8a-8add-4e93-98c1-e3866f1d9a2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredIncome_f918796c-abf8-4e6d-882c-07d2c8217ff3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_DeferredIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_inph_BesoinEnFondsDeRoulement_f15317f3-89c4-4f6a-9e0e-df73eb450287" xlink:to="loc_ifrs-full_DeferredIncome_f918796c-abf8-4e6d-882c-07d2c8217ff3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_DettesSurCollaborationPartCouranteEtNonCourante_ce7b9bbd-3709-4aa4-b7c3-369898358dd2" xlink:href="inph-2021-12-31.xsd#inph_DettesSurCollaborationPartCouranteEtNonCourante"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_inph_BesoinEnFondsDeRoulement_f15317f3-89c4-4f6a-9e0e-df73eb450287" xlink:to="loc_inph_DettesSurCollaborationPartCouranteEtNonCourante_ce7b9bbd-3709-4aa4-b7c3-369898358dd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_85a8ce7e-8aca-408c-affa-709c4db98198" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_5ede61e6-5980-43d0-8b44-99ae0510f50b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_85a8ce7e-8aca-408c-affa-709c4db98198" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_5ede61e6-5980-43d0-8b44-99ae0510f50b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_AjustementsPourAugmentationDiminutionDeDettesSurCollaborationCourantesEtNonCourantes_f9ef075b-407a-4405-bd1d-c506ae1ab91c" xlink:href="inph-2021-12-31.xsd#inph_AjustementsPourAugmentationDiminutionDeDettesSurCollaborationCourantesEtNonCourantes"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_85a8ce7e-8aca-408c-affa-709c4db98198" xlink:to="loc_inph_AjustementsPourAugmentationDiminutionDeDettesSurCollaborationCourantesEtNonCourantes_f9ef075b-407a-4405-bd1d-c506ae1ab91c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables_ccb60db8-ec7f-455f-b104-4e4a0fb4b1df" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_85a8ce7e-8aca-408c-affa-709c4db98198" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables_ccb60db8-ec7f-455f-b104-4e4a0fb4b1df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDeferredIncome_0678ebb4-57f1-43bc-b337-d9297a342c42" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInDeferredIncome"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_85a8ce7e-8aca-408c-affa-709c4db98198" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInDeferredIncome_0678ebb4-57f1-43bc-b337-d9297a342c42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_008bcc59-9980-4f5f-8961-d6576f52af2f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_666fba6d-57c4-4a2c-b7ab-2c3cf70d4209" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_008bcc59-9980-4f5f-8961-d6576f52af2f" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_666fba6d-57c4-4a2c-b7ab-2c3cf70d4209" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_ba1fa42f-9b55-4bee-b75f-bbfb89b6a5a9" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_008bcc59-9980-4f5f-8961-d6576f52af2f" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_ba1fa42f-9b55-4bee-b75f-bbfb89b6a5a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_fbea03e7-e74a-4f75-907a-af92031763e6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_008bcc59-9980-4f5f-8961-d6576f52af2f" xlink:to="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_fbea03e7-e74a-4f75-907a-af92031763e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_e99337aa-f516-4ab7-9db7-4a5c042e41b5" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_008bcc59-9980-4f5f-8961-d6576f52af2f" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_e99337aa-f516-4ab7-9db7-4a5c042e41b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_cfd143a4-c648-467a-90e5-b23c0dbfde46" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingShares_9ecfbefd-3b3e-400c-a615-20b4840bf7ad" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromIssuingShares"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_cfd143a4-c648-467a-90e5-b23c0dbfde46" xlink:to="loc_ifrs-full_ProceedsFromIssuingShares_9ecfbefd-3b3e-400c-a615-20b4840bf7ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_72029749-598a-492a-968a-392cd630cb05" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_cfd143a4-c648-467a-90e5-b23c0dbfde46" xlink:to="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_72029749-598a-492a-968a-392cd630cb05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_e20420d6-dd84-4155-ae57-d41c24747214" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_InterestPaidClassifiedAsFinancingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_cfd143a4-c648-467a-90e5-b23c0dbfde46" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_e20420d6-dd84-4155-ae57-d41c24747214" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_RemboursementsDesPassifsFinanciers_4849017b-3446-4dc0-a1d2-208838e30374" xlink:href="inph-2021-12-31.xsd#inph_RemboursementsDesPassifsFinanciers"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_cfd143a4-c648-467a-90e5-b23c0dbfde46" xlink:to="loc_inph_RemboursementsDesPassifsFinanciers_4849017b-3446-4dc0-a1d2-208838e30374" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_AugmentationDeCapitalNet_14f38216-1426-4071-9faa-646c525ec65f" xlink:href="inph-2021-12-31.xsd#inph_AugmentationDeCapitalNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_cfd143a4-c648-467a-90e5-b23c0dbfde46" xlink:to="loc_inph_AugmentationDeCapitalNet_14f38216-1426-4071-9faa-646c525ec65f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_add72354-7b1a-416d-8258-a221f09dad1b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_d9d681f2-28a8-4477-ade4-fd952d8745b1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_add72354-7b1a-416d-8258-a221f09dad1b" xlink:to="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_d9d681f2-28a8-4477-ade4-fd952d8745b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_d1ca9b63-c785-4882-8af4-5943556de479" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_add72354-7b1a-416d-8258-a221f09dad1b" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_d1ca9b63-c785-4882-8af4-5943556de479" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_04592ed2-52a2-480c-86cd-be68257352c7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForFairValueGainsLosses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_04592ed2-52a2-480c-86cd-be68257352c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_AjustementPourVariationDesProvisionsDInteretsSurActifsFinanciers_8d15f6e8-b50a-4528-8b9f-57c7cbff896c" xlink:href="inph-2021-12-31.xsd#inph_AjustementPourVariationDesProvisionsDInteretsSurActifsFinanciers"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_inph_AjustementPourVariationDesProvisionsDInteretsSurActifsFinanciers_8d15f6e8-b50a-4528-8b9f-57c7cbff896c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_09fc57d1-3929-46c4-a181-60b4fe1557fc" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_09fc57d1-3929-46c4-a181-60b4fe1557fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceCosts_b377f650-718b-4bdd-b70c-f3936fd48c19" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForFinanceCosts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForFinanceCosts_b377f650-718b-4bdd-b70c-f3936fd48c19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_79f47a5d-fad1-4c8f-9ab5-91c4d7f46293" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInEmployeeBenefitLiabilities_79f47a5d-fad1-4c8f-9ab5-91c4d7f46293" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_4a6cc96f-745d-4969-b114-2260e518d131" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_ProfitLoss_4a6cc96f-745d-4969-b114-2260e518d131" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_675e9665-bc95-4b59-868c-98efd16263d1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_675e9665-bc95-4b59-868c-98efd16263d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForProvisions_99164b93-e7fd-4c24-8f9a-9bb4ff50ba15" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForProvisions"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForProvisions_99164b93-e7fd-4c24-8f9a-9bb4ff50ba15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_2e9e3420-09be-4cbf-8649-095931d31b61" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_2e9e3420-09be-4cbf-8649-095931d31b61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss_4eb51ac6-0750-43f5-873c-8e75c1a93e54" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherAdjustmentsToReconcileProfitLoss"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss_4eb51ac6-0750-43f5-873c-8e75c1a93e54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceIncome_01ea4bd4-4ab7-4454-98c3-0a0385fcccdc" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForFinanceIncome"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_cb4a24c0-f5d4-4483-9a2c-6376f001c0e6" xlink:to="loc_ifrs-full_AdjustmentsForFinanceIncome_01ea4bd4-4ab7-4454-98c3-0a0385fcccdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_c2d440dc-e298-43e8-aedc-2b8574c982a7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_c2d440dc-e298-43e8-aedc-2b8574c982a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_c06588ef-cd75-41b9-9341-3c11bb704cb6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_c06588ef-cd75-41b9-9341-3c11bb704cb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_inph_CessionDActifsFinanciersNonCourants_2a5d05f0-7b66-43f6-9649-4b907d934a9d" xlink:href="inph-2021-12-31.xsd#inph_CessionDActifsFinanciersNonCourants"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_inph_CessionDActifsFinanciersNonCourants_2a5d05f0-7b66-43f6-9649-4b907d934a9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromOtherLongtermAssetsClassifiedAsInvestingActivities_b6b904bc-3f9b-4e52-bb5f-b925f738e753" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromOtherLongtermAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_ifrs-full_ProceedsFromOtherLongtermAssetsClassifiedAsInvestingActivities_b6b904bc-3f9b-4e52-bb5f-b925f738e753" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_b9c70fba-e4cd-4ae3-9f46-48c43d9823bf" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_b9c70fba-e4cd-4ae3-9f46-48c43d9823bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_3b280697-07c0-456c-9168-f3b65850fd50" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_3b280697-07c0-456c-9168-f3b65850fd50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsInvestingActivities_891b54b3-4c86-4b4f-a00a-4238ebfc4e8c" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_InterestReceivedClassifiedAsInvestingActivities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsInvestingActivities_891b54b3-4c86-4b4f-a00a-4238ebfc4e8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities_6009514d-fa5b-474b-a560-d43cd4fcd9b1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_4a5256ad-ce2f-4052-a068-6846e4ab8955" xlink:to="loc_ifrs-full_PurchaseOfOtherLongtermAssetsClassifiedAsInvestingActivities_6009514d-fa5b-474b-a560-d43cd4fcd9b1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.innate-pharma.com/role/tatdesvariationsdescapitauxpropres" xlink:type="simple" xlink:href="inph-2021-12-31.xsd#tatdesvariationsdescapitauxpropres"/>
  <link:calculationLink xlink:role="http://www.innate-pharma.com/role/tatdesvariationsdescapitauxpropres" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_ec787cb5-7f66-4b96-8dd3-db529de710eb" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_305ded4e-0e09-4d06-9f55-6c6f683f6765" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_ec787cb5-7f66-4b96-8dd3-db529de710eb" xlink:to="loc_ifrs-full_ProfitLoss_305ded4e-0e09-4d06-9f55-6c6f683f6765" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_c6cd618b-bc4f-4ebc-99e8-e4e343e1f518" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_ec787cb5-7f66-4b96-8dd3-db529de710eb" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_c6cd618b-bc4f-4ebc-99e8-e4e343e1f518" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_c082292d-ebf8-4247-a6c3-e2b961a54a86" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_ec787cb5-7f66-4b96-8dd3-db529de710eb" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_c082292d-ebf8-4247-a6c3-e2b961a54a86" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
