<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:8804e1e6-7737-4692-a280-63db6fb7a744,g:32b04e7b-a343-4ea2-8ef5-14f65b09db2e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:arcroleRef arcroleURI="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd#wider-narrower"/>
  <link:roleRef roleURI="http://www.grifols.com/role/EstadodecambiosenelpatrimonionetoStatement" xlink:type="simple" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#EstadodecambiosenelpatrimonionetoStatement"/>
  <link:definitionLink xlink:role="http://www.grifols.com/role/EstadodecambiosenelpatrimonionetoStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityAbstract_0f495c95-099d-4287-b3f7-780c0d5ab564" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityTable_fcabd73e-752a-40df-ad47-8e351008853e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_0f495c95-099d-4287-b3f7-780c0d5ab564" xlink:to="loc_ifrs-full_StatementOfChangesInEquityTable_fcabd73e-752a-40df-ad47-8e351008853e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComponentsOfEquityAxis_a954b9ca-54c0-4327-a211-2f97dd1c3e85" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComponentsOfEquityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_StatementOfChangesInEquityTable_fcabd73e-752a-40df-ad47-8e351008853e" xlink:to="loc_ifrs-full_ComponentsOfEquityAxis_a954b9ca-54c0-4327-a211-2f97dd1c3e85" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComponentsOfEquityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_ComponentsOfEquityAxis_a954b9ca-54c0-4327-a211-2f97dd1c3e85" xlink:to="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapitalMember_2fd3cfdc-30f3-4ae2-b43a-6afec3a2b68a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IssuedCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_IssuedCapitalMember_2fd3cfdc-30f3-4ae2-b43a-6afec3a2b68a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremiumMember_d777a8e8-bd45-4112-8147-1a21b4479f3c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SharePremiumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_SharePremiumMember_d777a8e8-bd45-4112-8147-1a21b4479f3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ReservasMember_106cdf8f-3939-4c7f-a449-766ba4deed5f" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ReservasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_grfs_ReservasMember_106cdf8f-3939-4c7f-a449-766ba4deed5f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_BeneficioDelPeriodoAtribuibleALaEmpresaMatrizMember_ff2246bf-80b2-48b9-82d8-3b7941f72f07" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_BeneficioDelPeriodoAtribuibleALaEmpresaMatrizMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_grfs_BeneficioDelPeriodoAtribuibleALaEmpresaMatrizMember_ff2246bf-80b2-48b9-82d8-3b7941f72f07" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_DividendoACuentaMember_754b9ae0-22b9-4174-ba90-5d5631678ea7" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_DividendoACuentaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_grfs_DividendoACuentaMember_754b9ae0-22b9-4174-ba90-5d5631678ea7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasurySharesMember_c0d9c07a-f029-46c1-87ee-5a7fded9ca97" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TreasurySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_TreasurySharesMember_c0d9c07a-f029-46c1-87ee-5a7fded9ca97" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_860d031c-bf06-4531-aa1a-3f648d3ccd41" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_860d031c-bf06-4531-aa1a-3f648d3ccd41" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalOtrosMember_a419cd33-3170-4771-9091-18e9fa986d80" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalOtrosMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_grfs_OtroResultadoGlobalOtrosMember_a419cd33-3170-4771-9091-18e9fa986d80" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssetsHeldForSaleMember_3fc61865-c3fe-45ea-ab7a-83ee56205124" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssetsHeldForSaleMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_NoncurrentAssetsHeldForSaleMember_3fc61865-c3fe-45ea-ab7a-83ee56205124" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfGainsAndLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeMember_a7a2246b-0e5a-4414-8b47-a9cf335cc67c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReserveOfGainsAndLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_ReserveOfGainsAndLossesOnFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncomeMember_a7a2246b-0e5a-4414-8b47-a9cf335cc67c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfCashFlowHedgesMember_905ef26f-b79e-4d65-a2de-94daca9190d8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReserveOfCashFlowHedgesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_ReserveOfCashFlowHedgesMember_905ef26f-b79e-4d65-a2de-94daca9190d8" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_1e0d574c-832e-4381-9b74-f8ee19e2a5e2" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_1e0d574c-832e-4381-9b74-f8ee19e2a5e2" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterestsMember_892d4ae6-7f01-48d4-b893-c77f950e8413" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncontrollingInterestsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_0c4a45f0-12ee-4c78-aa72-c0912a61eaf4" xlink:to="loc_ifrs-full_NoncontrollingInterestsMember_892d4ae6-7f01-48d4-b893-c77f950e8413" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetrospectiveApplicationAndRetrospectiveRestatementAxis_6edfc9d9-23db-4f08-8a48-ece09885a6f5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RetrospectiveApplicationAndRetrospectiveRestatementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_StatementOfChangesInEquityTable_fcabd73e-752a-40df-ad47-8e351008853e" xlink:to="loc_ifrs-full_RetrospectiveApplicationAndRetrospectiveRestatementAxis_6edfc9d9-23db-4f08-8a48-ece09885a6f5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RestatedMember_7638988c-6782-4d59-9cd2-df73ff3bffdb" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RestatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_RetrospectiveApplicationAndRetrospectiveRestatementAxis_6edfc9d9-23db-4f08-8a48-ece09885a6f5" xlink:to="loc_ifrs-full_RestatedMember_7638988c-6782-4d59-9cd2-df73ff3bffdb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PreviouslyStatedMember_3085dc81-21b0-42bb-8942-b34322a01e25" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PreviouslyStatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_RestatedMember_7638988c-6782-4d59-9cd2-df73ff3bffdb" xlink:to="loc_ifrs-full_PreviouslyStatedMember_3085dc81-21b0-42bb-8942-b34322a01e25" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialEffectOfCorrectionsOfAccountingErrorsMember_6c3a2838-0e60-4634-9096-00e003386183" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinancialEffectOfCorrectionsOfAccountingErrorsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_RestatedMember_7638988c-6782-4d59-9cd2-df73ff3bffdb" xlink:to="loc_ifrs-full_FinancialEffectOfCorrectionsOfAccountingErrorsMember_6c3a2838-0e60-4634-9096-00e003386183" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityLineItems"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_0f495c95-099d-4287-b3f7-780c0d5ab564" xlink:to="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_c023f857-a75a-4225-976c-852eb7e42fb3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_Equity_c023f857-a75a-4225-976c-852eb7e42fb3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_DiferenciasDeConversion_5f648643-b8e3-4274-903d-8f6cab05ad62" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_DiferenciasDeConversion"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_grfs_DiferenciasDeConversion_5f648643-b8e3-4274-903d-8f6cab05ad62" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_4f450bb0-c2d1-49e8-b0cd-c6ff2dfb6708" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxCashFlowHedges_4f450bb0-c2d1-49e8-b0cd-c6ff2dfb6708" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalNetoDeImpuestosOtros_74f961a6-cebb-4ad1-be4c-e064819ccf4d" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalNetoDeImpuestosOtros"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_grfs_OtroResultadoGlobalNetoDeImpuestosOtros_74f961a6-cebb-4ad1-be4c-e064819ccf4d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnDisposalsOfNoncurrentAssets_e74ea7c2-c1d4-4b36-9496-031a2bd82bfd" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnDisposalsOfNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_GainsLossesOnDisposalsOfNoncurrentAssets_e74ea7c2-c1d4-4b36-9496-031a2bd82bfd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_1bd9e5e5-97a1-4cce-807d-1335d45404ba" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome_1bd9e5e5-97a1-4cce-807d-1335d45404ba" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_c10db1f1-39fa-4fc4-ae69-6e656aaff14c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_c10db1f1-39fa-4fc4-ae69-6e656aaff14c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_b1e6ddc7-60cb-4251-8ba9-cf964ae6a523" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_ProfitLoss_b1e6ddc7-60cb-4251-8ba9-cf964ae6a523" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoGlobalTotalDelEjercicio_f702ec56-abdf-4bd0-ac13-8a161f715499" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoGlobalTotalDelEjercicio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_grfs_ResultadoGlobalTotalDelEjercicio_f702ec56-abdf-4bd0-ac13-8a161f715499" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_c70fe434-5e77-4f45-9d12-cc32d565a645" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_ComprehensiveIncome_c70fe434-5e77-4f45-9d12-cc32d565a645" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughTreasuryShareTransactions_4e10ce42-d54d-48fa-8853-2ab09b917b0c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughTreasuryShareTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughTreasuryShareTransactions_4e10ce42-d54d-48fa-8853-2ab09b917b0c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl_7610fd33-3a0a-4b50-8aad-f907237fbf73" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl_7610fd33-3a0a-4b50-8aad-f907237fbf73" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_fb213fd6-814f-4331-a010-602686aa90ab" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_fb213fd6-814f-4331-a010-602686aa90ab" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_AjusteALasReservasDistribucionDeLosBeneficiosDelAnoAnterior_eda1053f-ce71-4f9f-8149-c20ebe3c3f0c" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_AjusteALasReservasDistribucionDeLosBeneficiosDelAnoAnterior"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_grfs_AjusteALasReservasDistribucionDeLosBeneficiosDelAnoAnterior_eda1053f-ce71-4f9f-8149-c20ebe3c3f0c" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaid_b83f79c3-ec2a-4ade-b063-0cf80c28a405" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_DividendsPaid_b83f79c3-ec2a-4ade-b063-0cf80c28a405" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent_efcc01c3-8da3-4e29-9440-f039810db447" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent_efcc01c3-8da3-4e29-9440-f039810db447" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OperacionesConSociosOPropietarios_a479e593-5e66-471d-b5c7-2e924c127d05" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OperacionesConSociosOPropietarios"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_f4f80914-abcf-4642-ae76-1eca485a4699" xlink:to="loc_grfs_OperacionesConSociosOPropietarios_a479e593-5e66-471d-b5c7-2e924c127d05" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_d72d6079-f645-4151-9499-61c4fd1d574f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
  </link:definitionLink>
  <link:roleRef roleURI="https://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="simple" xlink:href="https://www.esma.europa.eu/taxonomy/2024-03-27/esef_cor.xsd#esef_role-999999"/>
  <link:definitionLink xlink:role="https://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:href="https://www.esma.europa.eu/taxonomy/2024-03-27/esef_cor.xsd#esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_7f767cc1-507e-4189-9d33-44aee7a93b32NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Goodwill_7f767cc1-507e-4189-9d33-44aee7a93b32NotDimensionallyQualified" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_82a44f9a-0898-4bce-a2d5-013782effbe0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_82a44f9a-0898-4bce-a2d5-013782effbe0NotDimensionallyQualified" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_a46b36ea-367b-48a3-ac7a-c1ba5eb87bc9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RightofuseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RightofuseAssets_a46b36ea-367b-48a3-ac7a-c1ba5eb87bc9NotDimensionallyQualified" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_0c50b770-9e90-442f-a39e-c7b1187383a4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_0c50b770-9e90-442f-a39e-c7b1187383a4NotDimensionallyQualified" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_2b2a8cb3-34de-41f3-ba32-e44b13f78facNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InvestmentAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_2b2a8cb3-34de-41f3-ba32-e44b13f78facNotDimensionallyQualified" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLossDesignatedUponInitialRecognition_c359b272-de82-4099-b0fc-951dbaa75cc1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLossDesignatedUponInitialRecognition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLossDesignatedUponInitialRecognition_c359b272-de82-4099-b0fc-951dbaa75cc1NotDimensionallyQualified" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssetsAtAmortisedCost_d213fd52-f5f5-4c24-bcba-58435c182c9fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentFinancialAssetsAtAmortisedCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinancialAssetsAtAmortisedCost_d213fd52-f5f5-4c24-bcba-58435c182c9fNotDimensionallyQualified" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssets_72621533-7e27-4c83-b9a2-e101a4f60f72NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentFinancialAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinancialAssets_72621533-7e27-4c83-b9a2-e101a4f60f72NotDimensionallyQualified" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_695c3823-151b-4bb7-b714-57917d2d8a6aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_695c3823-151b-4bb7-b714-57917d2d8a6aNotDimensionallyQualified" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_afdf1397-c837-414a-83ed-597edb13f51aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DeferredTaxAssets_afdf1397-c837-414a-83ed-597edb13f51aNotDimensionallyQualified" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_9d708a02-aa3b-464e-9b77-9a82d449e5caNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentAssets_9d708a02-aa3b-464e-9b77-9a82d449e5caNotDimensionallyQualified" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_c77358f1-4325-4913-a528-71c262dd8906NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Inventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Inventories_c77358f1-4325-4913-a528-71c262dd8906NotDimensionallyQualified" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractAssets_8bd68ac2-c67c-42f2-a3b9-3fd2a29088bbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentContractAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentContractAssets_8bd68ac2-c67c-42f2-a3b9-3fd2a29088bbNotDimensionallyQualified" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTradeReceivables_fed03fff-8a81-4468-b822-f4467d02f1a8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTradeReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTradeReceivables_fed03fff-8a81-4468-b822-f4467d02f1a8NotDimensionallyQualified" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentReceivables_0a40d879-c25e-4fab-b8cd-a03b8ba311e4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCurrentReceivables_0a40d879-c25e-4fab-b8cd-a03b8ba311e4NotDimensionallyQualified" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_3630608c-c56b-4d73-ac7d-f4090d18b9c0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_3630608c-c56b-4d73-ac7d-f4090d18b9c0NotDimensionallyQualified" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_78564195-9902-489c-8dea-d4049b13787aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_78564195-9902-489c-8dea-d4049b13787aNotDimensionallyQualified" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinancialAssetsAtFairValue_019c2826-cc48-7d31-bd1d-a39940d5bc3fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinancialAssetsAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinancialAssetsAtFairValue_019c2826-cc48-7d31-bd1d-a39940d5bc3fNotDimensionallyQualified" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialAssetsAtAmortisedCost_019c2827-564a-7078-9854-a4de154d9762NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentFinancialAssetsAtAmortisedCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentFinancialAssetsAtAmortisedCost_019c2827-564a-7078-9854-a4de154d9762NotDimensionallyQualified" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialAssets_4aeb93da-5aa5-4004-b034-69a664720b5dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentFinancialAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentFinancialAssets_4aeb93da-5aa5-4004-b034-69a664720b5dNotDimensionallyQualified" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentAssets_034cc9d1-a1a2-462a-98fe-5172a58168a4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCurrentAssets_034cc9d1-a1a2-462a-98fe-5172a58168a4NotDimensionallyQualified" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_EfectivoYOtrosMediosLiquidosEquivalentes_7f87e40a-61b5-47e4-aab6-1fc0a4af05a3NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_EfectivoYOtrosMediosLiquidosEquivalentes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_EfectivoYOtrosMediosLiquidosEquivalentes_7f87e40a-61b5-47e4-aab6-1fc0a4af05a3NotDimensionallyQualified" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_cf987fe4-30ac-4f15-85f2-943f5fb601f4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentAssets_cf987fe4-30ac-4f15-85f2-943f5fb601f4NotDimensionallyQualified" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_71bea586-6e6a-4dac-80e1-b8e0312d9a8aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Assets_71bea586-6e6a-4dac-80e1-b8e0312d9a8aNotDimensionallyQualified" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_6429033e-6a06-49cb-9c53-701837edaaebNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IssuedCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IssuedCapital_6429033e-6a06-49cb-9c53-701837edaaebNotDimensionallyQualified" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_cd4e69f3-4b17-4465-b31d-87c9fa54955eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SharePremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_SharePremium_cd4e69f3-4b17-4465-b31d-87c9fa54955eNotDimensionallyQualified" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_Reservas_82c6b08f-b4f7-48f8-b6c1-380aeb48cf11NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_Reservas"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_Reservas_82c6b08f-b4f7-48f8-b6c1-380aeb48cf11NotDimensionallyQualified" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_DividendoACuenta_019c707c-48dc-75fd-b309-41269a933bcaNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_DividendoACuenta"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_DividendoACuenta_019c707c-48dc-75fd-b309-41269a933bcaNotDimensionallyQualified" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasuryShares_604a2437-20b8-4f76-a1e9-2edbfba57fa2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TreasuryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TreasuryShares_604a2437-20b8-4f76-a1e9-2edbfba57fa2NotDimensionallyQualified" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoDelEjercicioAtribuidoALaSociedadDominante_d6a98139-4aa0-439a-8104-15998de6dd4fNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoDelEjercicioAtribuidoALaSociedadDominante"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_ResultadoDelEjercicioAtribuidoALaSociedadDominante_d6a98139-4aa0-439a-8104-15998de6dd4fNotDimensionallyQualified" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_TotalFondosPropio_019c298a-05b7-743e-83a3-b51383f8168bNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_TotalFondosPropio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_TotalFondosPropio_019c298a-05b7-743e-83a3-b51383f8168bNotDimensionallyQualified" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfCashFlowHedges_17da00d4-479a-469b-9989-f0411dd52041NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReserveOfCashFlowHedges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ReserveOfCashFlowHedges_17da00d4-479a-469b-9989-f0411dd52041NotDimensionallyQualified" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ReservaDeOtrosIngresosIntegralesDiversos_e3ca1900-8120-4f89-9a05-a28799a68949NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ReservaDeOtrosIngresosIntegralesDiversos"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_ReservaDeOtrosIngresosIntegralesDiversos_e3ca1900-8120-4f89-9a05-a28799a68949NotDimensionallyQualified" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalDerivadoDeLaValoracionDeInstrumentosFinancieros_204adced-3251-4e4f-8575-1c4d26e0abd1NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalDerivadoDeLaValoracionDeInstrumentosFinancieros"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_OtroResultadoGlobalDerivadoDeLaValoracionDeInstrumentosFinancieros_204adced-3251-4e4f-8575-1c4d26e0abd1NotDimensionallyQualified" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_901d879f-da5d-4ae9-8238-dd40a179c9d9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_901d879f-da5d-4ae9-8238-dd40a179c9d9NotDimensionallyQualified" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalAcumuladoExcluyendoLasCoberturasDeFlujosDeEfectivo_f9f5afe1-cf25-46c5-bcf9-28d250d1f7b4NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalAcumuladoExcluyendoLasCoberturasDeFlujosDeEfectivo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_OtroResultadoGlobalAcumuladoExcluyendoLasCoberturasDeFlujosDeEfectivo_f9f5afe1-cf25-46c5-bcf9-28d250d1f7b4NotDimensionallyQualified" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_09a55fa6-9cac-4ffc-b084-d1993eb1bc20NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_09a55fa6-9cac-4ffc-b084-d1993eb1bc20NotDimensionallyQualified" xlink:type="arc" order="36"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_a4512360-5d2c-4c63-a6b3-f4ade2b5ed7bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncontrollingInterests_a4512360-5d2c-4c63-a6b3-f4ade2b5ed7bNotDimensionallyQualified" xlink:type="arc" order="37"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_8345a6f8-1816-4976-a04b-cb76a2a50427NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Equity_8345a6f8-1816-4976-a04b-cb76a2a50427NotDimensionallyQualified" xlink:type="arc" order="38"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentGovernmentGrants_b4b595a1-1b55-4b1a-9a16-77b7f4ca3bd1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentGovernmentGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentGovernmentGrants_b4b595a1-1b55-4b1a-9a16-77b7f4ca3bd1NotDimensionallyQualified" xlink:type="arc" order="39"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions_8e11720a-2043-43f9-a42a-5c462da45b52NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentProvisions_8e11720a-2043-43f9-a42a-5c462da45b52NotDimensionallyQualified" xlink:type="arc" order="40"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilities_c71fe6fd-7cc6-4724-846f-b1163372809fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentFinancialLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilities_c71fe6fd-7cc6-4724-846f-b1163372809fNotDimensionallyQualified" xlink:type="arc" order="41"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentLiabilities_f7f423e8-05c1-4a39-b565-3b12b4f36671NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherNoncurrentLiabilities_f7f423e8-05c1-4a39-b565-3b12b4f36671NotDimensionallyQualified" xlink:type="arc" order="42"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_18b23b62-2c6c-4010-b0da-d66f70705befNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_18b23b62-2c6c-4010-b0da-d66f70705befNotDimensionallyQualified" xlink:type="arc" order="43"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_b9b4556e-1bd7-4fe7-8f52-64b949e2c714NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentLiabilities_b9b4556e-1bd7-4fe7-8f52-64b949e2c714NotDimensionallyQualified" xlink:type="arc" order="44"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_ddfa439f-ae9c-4f3e-ba73-34173a37012aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentProvisions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentProvisions_ddfa439f-ae9c-4f3e-ba73-34173a37012aNotDimensionallyQualified" xlink:type="arc" order="45"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinancialLiabilities_1bea1e72-1b0d-4e70-88c3-c76c24567012NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentFinancialLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentFinancialLiabilities_1bea1e72-1b0d-4e70-88c3-c76c24567012NotDimensionallyQualified" xlink:type="arc" order="46"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_3c24fc97-6952-486e-bfd8-a9d0f6c8ee24NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_3c24fc97-6952-486e-bfd8-a9d0f6c8ee24NotDimensionallyQualified" xlink:type="arc" order="47"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentPayables_dff614b7-b683-4af9-88f4-e0d7965741faNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCurrentPayables_dff614b7-b683-4af9-88f4-e0d7965741faNotDimensionallyQualified" xlink:type="arc" order="48"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_28928da9-f16e-4f0a-b19b-67c1cdc51810NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_28928da9-f16e-4f0a-b19b-67c1cdc51810NotDimensionallyQualified" xlink:type="arc" order="49"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_68323310-fdad-453f-93de-302d1863acdbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_68323310-fdad-453f-93de-302d1863acdbNotDimensionallyQualified" xlink:type="arc" order="50"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities_9a8ea0d1-5cd2-4533-afb0-05ccab037f7cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCurrentLiabilities_9a8ea0d1-5cd2-4533-afb0-05ccab037f7cNotDimensionallyQualified" xlink:type="arc" order="51"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_8618b72f-cac1-432b-9de7-9ea84dbe4bfbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentLiabilities_8618b72f-cac1-432b-9de7-9ea84dbe4bfbNotDimensionallyQualified" xlink:type="arc" order="52"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_541689b8-a316-4dca-8557-a97d27da954cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Liabilities_541689b8-a316-4dca-8557-a97d27da954cNotDimensionallyQualified" xlink:type="arc" order="53"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_c9404603-de18-43d7-9bb2-4e1b2cfaca06NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAndLiabilities_c9404603-de18-43d7-9bb2-4e1b2cfaca06NotDimensionallyQualified" xlink:type="arc" order="54"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_90bed9c1-11ce-4ef0-b9bb-2c998bff8419NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Revenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Revenue_90bed9c1-11ce-4ef0-b9bb-2c998bff8419NotDimensionallyQualified" xlink:type="arc" order="55"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales_b0576e61-de94-4972-a88d-d7cb50423659NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CostOfSales"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CostOfSales_b0576e61-de94-4972-a88d-d7cb50423659NotDimensionallyQualified" xlink:type="arc" order="56"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GrossProfit_3b1e909a-5c2a-4fea-8082-6b08e2724cb1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GrossProfit_3b1e909a-5c2a-4fea-8082-6b08e2724cb1NotDimensionallyQualified" xlink:type="arc" order="57"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_ae9e0ddc-733c-4f8a-bdee-a06b68394978NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_ae9e0ddc-733c-4f8a-bdee-a06b68394978NotDimensionallyQualified" xlink:type="arc" order="58"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_2bf04bd4-0760-4a51-95e4-f55d1acd02d5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_2bf04bd4-0760-4a51-95e4-f55d1acd02d5NotDimensionallyQualified" xlink:type="arc" order="59"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpense_a7aef985-eacd-41ba-927a-093a9cf253c0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OperatingExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OperatingExpense_a7aef985-eacd-41ba-927a-093a9cf253c0NotDimensionallyQualified" xlink:type="arc" order="60"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherIncome_24db97d7-fd6c-45c9-866e-81161a9c2f0fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherIncome_24db97d7-fd6c-45c9-866e-81161a9c2f0fNotDimensionallyQualified" xlink:type="arc" order="61"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacionConActividadSimilarALaDelGrupo_b8b431de-3e63-4478-80c6-0a4498e7ca73NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacionConActividadSimilarALaDelGrupo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacionConActividadSimilarALaDelGrupo_b8b431de-3e63-4478-80c6-0a4498e7ca73NotDimensionallyQualified" xlink:type="arc" order="62"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_994e8e4f-18bc-4863-b2f0-320862ae18b2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_994e8e4f-18bc-4863-b2f0-320862ae18b2NotDimensionallyQualified" xlink:type="arc" order="63"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_73a6bef7-b9d3-46ab-ab80-f5f0fa23f6fbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceIncome_73a6bef7-b9d3-46ab-ab80-f5f0fa23f6fbNotDimensionallyQualified" xlink:type="arc" order="64"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_dc311a71-a177-46d5-902e-1aeedc025ba4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceCosts_dc311a71-a177-46d5-902e-1aeedc025ba4NotDimensionallyQualified" xlink:type="arc" order="65"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromDividends_51769dad-34d0-4d89-88b9-8a8c8e93edf7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RevenueFromDividends"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RevenueFromDividends_51769dad-34d0-4d89-88b9-8a8c8e93edf7NotDimensionallyQualified" xlink:type="arc" order="66"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_VentaDeActivosACosteAmortizado_2929b5ae-3d60-4f10-8068-fd5d9eebed78NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_VentaDeActivosACosteAmortizado"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_VentaDeActivosACosteAmortizado_2929b5ae-3d60-4f10-8068-fd5d9eebed78NotDimensionallyQualified" xlink:type="arc" order="67"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_VariacionDeValorRazonableEnInstrumentosFinancieros_3335a3e0-0a6f-4e0f-b7fd-c9ed65046323NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_VariacionDeValorRazonableEnInstrumentosFinancieros"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_VariacionDeValorRazonableEnInstrumentosFinancieros_3335a3e0-0a6f-4e0f-b7fd-c9ed65046323NotDimensionallyQualified" xlink:type="arc" order="68"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossImpairmentGainAndReversalOfImpairmentLossDeterminedInAccordanceWithIFRS9_019c2970-d3b5-794a-b3b2-63c461418c22NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ImpairmentLossImpairmentGainAndReversalOfImpairmentLossDeterminedInAccordanceWithIFRS9"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ImpairmentLossImpairmentGainAndReversalOfImpairmentLossDeterminedInAccordanceWithIFRS9_019c2970-d3b5-794a-b3b2-63c461418c22NotDimensionallyQualified" xlink:type="arc" order="69"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss_93be4400-a255-4d57-9322-6abff311bf0eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss_93be4400-a255-4d57-9322-6abff311bf0eNotDimensionallyQualified" xlink:type="arc" order="70"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_bc85e51a-ab47-4e9a-aa78-7398f2471d45NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceIncomeCost_bc85e51a-ab47-4e9a-aa78-7398f2471d45NotDimensionallyQualified" xlink:type="arc" order="71"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacion_2ef3aa13-5e40-4a2d-999e-0b5d1dd61873NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacion"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacion_2ef3aa13-5e40-4a2d-999e-0b5d1dd61873NotDimensionallyQualified" xlink:type="arc" order="72"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_f0b19d99-5d6b-4e6e-a2e3-1c6130c5bcd2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_f0b19d99-5d6b-4e6e-a2e3-1c6130c5bcd2NotDimensionallyQualified" xlink:type="arc" order="73"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_d0242e21-245f-49d1-9c69-2dc30e9eabe7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_d0242e21-245f-49d1-9c69-2dc30e9eabe7NotDimensionallyQualified" xlink:type="arc" order="74"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_5e07b565-d49f-4260-88fa-2671f13ff92bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossFromContinuingOperations_5e07b565-d49f-4260-88fa-2671f13ff92bNotDimensionallyQualified" xlink:type="arc" order="75"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_c6589caf-5442-4854-83df-888a9c176b67NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLoss_c6589caf-5442-4854-83df-888a9c176b67NotDimensionallyQualified" xlink:type="arc" order="76"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_20d1f56e-4cd0-4288-8892-203001bf40c7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_20d1f56e-4cd0-4288-8892-203001bf40c7NotDimensionallyQualified" xlink:type="arc" order="77"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_1ef1322f-8259-47fc-a0ea-262f9a726942NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_1ef1322f-8259-47fc-a0ea-262f9a726942NotDimensionallyQualified" xlink:type="arc" order="78"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BasicEarningsLossPerShareFromContinuingOperations_44db907a-ab51-4690-9ef6-4b271b672bcfNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BasicEarningsLossPerShareFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_BasicEarningsLossPerShareFromContinuingOperations_44db907a-ab51-4690-9ef6-4b271b672bcfNotDimensionallyQualified" xlink:type="arc" order="79"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DilutedEarningsLossPerShareFromContinuingOperations_8fc9a97f-11ff-4b62-9bc5-38a5445e0584NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DilutedEarningsLossPerShareFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DilutedEarningsLossPerShareFromContinuingOperations_8fc9a97f-11ff-4b62-9bc5-38a5445e0584NotDimensionallyQualified" xlink:type="arc" order="80"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_6811417a-4e46-4d9a-86b0-8327f73a51fbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_6811417a-4e46-4d9a-86b0-8327f73a51fbNotDimensionallyQualified" xlink:type="arc" order="81"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfOtherComprehensiveIncomeOfAssociatesAndJointVenturesAccountedForUsingEquityMethodThatWillBeReclassifiedToProfitOrLossNetOfTax_2352c492-2fff-4035-946a-4a18eb2582d6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ShareOfOtherComprehensiveIncomeOfAssociatesAndJointVenturesAccountedForUsingEquityMethodThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ShareOfOtherComprehensiveIncomeOfAssociatesAndJointVenturesAccountedForUsingEquityMethodThatWillBeReclassifiedToProfitOrLossNetOfTax_2352c492-2fff-4035-946a-4a18eb2582d6NotDimensionallyQualified" xlink:type="arc" order="82"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnDisposalsOfNoncurrentAssets_ea3e74ff-872f-4fa9-b180-210d4a211692NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnDisposalsOfNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesOnDisposalsOfNoncurrentAssets_ea3e74ff-872f-4fa9-b180-210d4a211692NotDimensionallyQualified" xlink:type="arc" order="83"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PorCoberturaDeFlujosDeEfectivoTransferenciaEnLaCuentaDePerdidasYGanancias_73bb3d9b-0f9c-43e4-8246-39d8c2521e1aNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PorCoberturaDeFlujosDeEfectivoTransferenciaEnLaCuentaDePerdidasYGanancias"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_PorCoberturaDeFlujosDeEfectivoTransferenciaEnLaCuentaDePerdidasYGanancias_73bb3d9b-0f9c-43e4-8246-39d8c2521e1aNotDimensionallyQualified" xlink:type="arc" order="84"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PorCoberturaDeflujosDeEfectivoIngresosYGastosImputadosDirectamenteAlPatrimonioNeto_1e4fda40-7201-4d23-901f-50f46e4a0078NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PorCoberturaDeflujosDeEfectivoIngresosYGastosImputadosDirectamenteAlPatrimonioNeto"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_PorCoberturaDeflujosDeEfectivoIngresosYGastosImputadosDirectamenteAlPatrimonioNeto_1e4fda40-7201-4d23-901f-50f46e4a0078NotDimensionallyQualified" xlink:type="arc" order="85"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalNetoDeImpuestosOtros_871341c8-bdf9-4aab-a927-8236f0e87900NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalNetoDeImpuestosOtros"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_OtroResultadoGlobalNetoDeImpuestosOtros_871341c8-bdf9-4aab-a927-8236f0e87900NotDimensionallyQualified" xlink:type="arc" order="86"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_fd67dd0a-b2bb-40fc-8d7d-24694071769bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_fd67dd0a-b2bb-40fc-8d7d-24694071769bNotDimensionallyQualified" xlink:type="arc" order="87"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_GananciasPerdidasEnLaValoracionDePlanesDeBeneficiosDefinidos_6d74d77e-e3d3-4f5d-87f6-af8f62be6125NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_GananciasPerdidasEnLaValoracionDePlanesDeBeneficiosDefinidos"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_GananciasPerdidasEnLaValoracionDePlanesDeBeneficiosDefinidos_6d74d77e-e3d3-4f5d-87f6-af8f62be6125NotDimensionallyQualified" xlink:type="arc" order="88"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss_598b441a-8475-4b83-aaf5-7add9f6fc3e7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesOnFinancialAssetsAtFairValueThroughProfitOrLoss_598b441a-8475-4b83-aaf5-7add9f6fc3e7NotDimensionallyQualified" xlink:type="arc" order="89"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_cdde197b-a7f8-4a33-8d91-e1b24f89e68fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_cdde197b-a7f8-4a33-8d91-e1b24f89e68fNotDimensionallyQualified" xlink:type="arc" order="90"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLoss_7a0f8c25-d935-4376-83bd-2c77390159afNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLoss_7a0f8c25-d935-4376-83bd-2c77390159afNotDimensionallyQualified" xlink:type="arc" order="91"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_5fb4cb4a-15e2-4619-8f95-54e1aa2e9b05NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_5fb4cb4a-15e2-4619-8f95-54e1aa2e9b05NotDimensionallyQualified" xlink:type="arc" order="92"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_059d5732-cfc2-416d-a67d-34477c9ec4a0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncome_059d5732-cfc2-416d-a67d-34477c9ec4a0NotDimensionallyQualified" xlink:type="arc" order="93"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_7bb5aae3-da18-4685-bf05-2bbfe3528626NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_7bb5aae3-da18-4685-bf05-2bbfe3528626NotDimensionallyQualified" xlink:type="arc" order="94"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_f1e1f1e2-8fb3-461f-add3-043bb58afe88NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_f1e1f1e2-8fb3-461f-add3-043bb58afe88NotDimensionallyQualified" xlink:type="arc" order="95"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForReconcileProfitLoss_602f4e1a-c29d-42aa-a1da-bdfc4cb48ea8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForReconcileProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForReconcileProfitLoss_602f4e1a-c29d-42aa-a1da-bdfc4cb48ea8NotDimensionallyQualified" xlink:type="arc" order="96"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_8ad88a3a-cc31-4e4a-bf9c-ade3812944ffNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_8ad88a3a-cc31-4e4a-bf9c-ade3812944ffNotDimensionallyQualified" xlink:type="arc" order="97"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss_de028922-98a5-4266-92d3-4077ce55dadfNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherAdjustmentsToReconcileProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss_de028922-98a5-4266-92d3-4077ce55dadfNotDimensionallyQualified" xlink:type="arc" order="98"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_384e97f9-f342-4fbc-ab87-8ba15aab6574NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_384e97f9-f342-4fbc-ab87-8ba15aab6574NotDimensionallyQualified" xlink:type="arc" order="99"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones_b6ba5e6e-6c0e-4984-b854-7e8cd0ec1e1fNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones_b6ba5e6e-6c0e-4984-b854-7e8cd0ec1e1fNotDimensionallyQualified" xlink:type="arc" order="100"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_96d36cc5-fff0-4547-976f-28d2a3057cf9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_96d36cc5-fff0-4547-976f-28d2a3057cf9NotDimensionallyQualified" xlink:type="arc" order="101"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_SubvencionesImputadasAlResultado_f6a1a898-f596-4fbf-9b50-b696c55483d3NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_SubvencionesImputadasAlResultado"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_SubvencionesImputadasAlResultado_f6a1a898-f596-4fbf-9b50-b696c55483d3NotDimensionallyQualified" xlink:type="arc" order="102"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceIncomeCost_85d288b4-f40f-4971-b196-6e8307f3c784NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForFinanceIncomeCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForFinanceIncomeCost_85d288b4-f40f-4971-b196-6e8307f3c784NotDimensionallyQualified" xlink:type="arc" order="103"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_9325ef04-16a8-47c8-a7d1-5c17e3da9637NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_9325ef04-16a8-47c8-a7d1-5c17e3da9637NotDimensionallyQualified" xlink:type="arc" order="104"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_7054ef50-8b8f-4b0f-87ed-b4b395e78199NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_7054ef50-8b8f-4b0f-87ed-b4b395e78199NotDimensionallyQualified" xlink:type="arc" order="105"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_b2bbf4ce-66ac-4e41-ae42-a1123f1e5fc6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInInventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_b2bbf4ce-66ac-4e41-ae42-a1123f1e5fc6NotDimensionallyQualified" xlink:type="arc" order="106"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_5b3a20f7-6f5b-429d-9bf2-dfbf9a663e51NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_5b3a20f7-6f5b-429d-9bf2-dfbf9a663e51NotDimensionallyQualified" xlink:type="arc" order="107"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_VariacionDeOtrosActivosFinancierosCorrientesYOtrosActivosCorrientes_c39f00b9-dd66-48b7-b1c1-42c4c693010bNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_VariacionDeOtrosActivosFinancierosCorrientesYOtrosActivosCorrientes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_VariacionDeOtrosActivosFinancierosCorrientesYOtrosActivosCorrientes_c39f00b9-dd66-48b7-b1c1-42c4c693010bNotDimensionallyQualified" xlink:type="arc" order="108"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables_f4e7eff8-7275-4183-acd2-5511a24f8d43NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAndOtherPayables_f4e7eff8-7275-4183-acd2-5511a24f8d43NotDimensionallyQualified" xlink:type="arc" order="109"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_032b58e2-38ea-44a3-955a-db6b2983601fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_032b58e2-38ea-44a3-955a-db6b2983601fNotDimensionallyQualified" xlink:type="arc" order="110"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_a722e311-a898-4ce2-b630-ac6db3885eb4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_a722e311-a898-4ce2-b630-ac6db3885eb4NotDimensionallyQualified" xlink:type="arc" order="111"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_3bf7d92a-0a04-4ce2-bd85-57f7187c1a7fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_3bf7d92a-0a04-4ce2-bd85-57f7187c1a7fNotDimensionallyQualified" xlink:type="arc" order="112"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_2d0268e4-7505-4182-8c36-183070d403baNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_2d0268e4-7505-4182-8c36-183070d403baNotDimensionallyQualified" xlink:type="arc" order="113"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtrosCobrosPagos_17a0505b-fb87-452d-8193-6035760cf755NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtrosCobrosPagos"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_OtrosCobrosPagos_17a0505b-fb87-452d-8193-6035760cf755NotDimensionallyQualified" xlink:type="arc" order="114"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_21a32b00-6806-492d-af15-6a3c216692c0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_21a32b00-6806-492d-af15-6a3c216692c0NotDimensionallyQualified" xlink:type="arc" order="115"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PagosPorInversiones_019c1ee1-1a4d-7dc6-b8bf-97764a47c83fNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PagosPorInversiones"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_PagosPorInversiones_019c1ee1-1a4d-7dc6-b8bf-97764a47c83fNotDimensionallyQualified" xlink:type="arc" order="116"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfInterestsInAssociates_d0dc0dd1-064c-453e-932e-05a0a6887b3bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfInterestsInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfInterestsInAssociates_d0dc0dd1-064c-453e-932e-05a0a6887b3bNotDimensionallyQualified" xlink:type="arc" order="117"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_InmovilizadoMaterialEIntangible_eb7eecd6-118b-4bdb-a286-79f0ee40e54fNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_InmovilizadoMaterialEIntangible"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_InmovilizadoMaterialEIntangible_eb7eecd6-118b-4bdb-a286-79f0ee40e54fNotDimensionallyQualified" xlink:type="arc" order="118"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_a5f5c281-6b8e-472f-a4b3-37de79bb4596NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_a5f5c281-6b8e-472f-a4b3-37de79bb4596NotDimensionallyQualified" xlink:type="arc" order="119"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_31c93130-94fb-4322-8d8f-c1e817cf1ac1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_31c93130-94fb-4322-8d8f-c1e817cf1ac1NotDimensionallyQualified" xlink:type="arc" order="120"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_CompraDeOtrosActivosFinancieros_75b8845f-e733-4302-8420-6d7c6a3c9a0fNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_CompraDeOtrosActivosFinancieros"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_CompraDeOtrosActivosFinancieros_75b8845f-e733-4302-8420-6d7c6a3c9a0fNotDimensionallyQualified" xlink:type="arc" order="121"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_CobrosPorDesinversiones_8cebf44f-1813-45aa-80ed-dfce5be0bf1fNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_CobrosPorDesinversiones"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_CobrosPorDesinversiones_8cebf44f-1813-45aa-80ed-dfce5be0bf1fNotDimensionallyQualified" xlink:type="arc" order="122"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfInterestsInAssociates_87322b19-f05b-46f1-a2ac-42274c373c6fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromSalesOfInterestsInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromSalesOfInterestsInAssociates_87322b19-f05b-46f1-a2ac-42274c373c6fNotDimensionallyQualified" xlink:type="arc" order="123"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_107bc28b-3577-463b-9fe8-5a17b78683aeNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_107bc28b-3577-463b-9fe8-5a17b78683aeNotDimensionallyQualified" xlink:type="arc" order="124"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ProductoDeLaVentaDeOtrosActivosFinancieros_548532cd-394c-42cd-b918-a5c9df2d150bNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ProductoDeLaVentaDeOtrosActivosFinancieros"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_ProductoDeLaVentaDeOtrosActivosFinancieros_548532cd-394c-42cd-b918-a5c9df2d150bNotDimensionallyQualified" xlink:type="arc" order="125"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_b4db30c8-4ec0-4d98-be14-c4fcdc009437NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_b4db30c8-4ec0-4d98-be14-c4fcdc009437NotDimensionallyQualified" xlink:type="arc" order="126"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero_09cd321b-9e39-44b1-8a16-c0ef5e804f67NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero_09cd321b-9e39-44b1-8a16-c0ef5e804f67NotDimensionallyQualified" xlink:type="arc" order="127"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_5d610923-57ed-4389-b1c6-4a80293ac951NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities_5d610923-57ed-4389-b1c6-4a80293ac951NotDimensionallyQualified" xlink:type="arc" order="128"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_aa126951-ca83-48ff-8eba-a02b95382e9dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities_aa126951-ca83-48ff-8eba-a02b95382e9dNotDimensionallyQualified" xlink:type="arc" order="129"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_8633f995-8bda-4980-816c-b26b3f5d77d1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_8633f995-8bda-4980-816c-b26b3f5d77d1NotDimensionallyQualified" xlink:type="arc" order="130"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PagosPorDividendosYRemuneracionesDeOtrosInstrumentosDePatrimonio_69901b7c-4f16-408f-b398-7e74c41695b3NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PagosPorDividendosYRemuneracionesDeOtrosInstrumentosDePatrimonio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_PagosPorDividendosYRemuneracionesDeOtrosInstrumentosDePatrimonio_69901b7c-4f16-408f-b398-7e74c41695b3NotDimensionallyQualified" xlink:type="arc" order="131"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidClassifiedAsFinancingActivities_732c9dd6-c3eb-4272-b8e4-8cf5f7ac9d78NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsPaidClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DividendsPaidClassifiedAsFinancingActivities_732c9dd6-c3eb-4272-b8e4-8cf5f7ac9d78NotDimensionallyQualified" xlink:type="arc" order="132"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_d5f224ab-e349-4ec4-9955-4aaadb0108bdNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_d5f224ab-e349-4ec4-9955-4aaadb0108bdNotDimensionallyQualified" xlink:type="arc" order="133"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsForDebtIssueCosts_4eb5bcc1-59fd-49e6-a1a8-d3cf867cbd86NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsForDebtIssueCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsForDebtIssueCosts_4eb5bcc1-59fd-49e6-a1a8-d3cf867cbd86NotDimensionallyQualified" xlink:type="arc" order="134"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_AdquisicionDeParticipacionesNoDominantes_019c2833-2cb4-73a4-b573-ec3bb540d6e3NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_AdquisicionDeParticipacionesNoDominantes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_AdquisicionDeParticipacionesNoDominantes_019c2833-2cb4-73a4-b573-ec3bb540d6e3NotDimensionallyQualified" xlink:type="arc" order="135"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtrosCobrosDeActividadesDeFinanciacion_21a9fcd7-cdfc-4554-a110-587120194448NotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtrosCobrosDeActividadesDeFinanciacion"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_OtrosCobrosDeActividadesDeFinanciacion_21a9fcd7-cdfc-4554-a110-587120194448NotDimensionallyQualified" xlink:type="arc" order="136"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_64f65813-85a2-4965-9f1a-6b4247037fd3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_64f65813-85a2-4965-9f1a-6b4247037fd3NotDimensionallyQualified" xlink:type="arc" order="137"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_d1c9096e-d2a6-4ed2-b09f-03869b81c5d3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_d1c9096e-d2a6-4ed2-b09f-03869b81c5d3NotDimensionallyQualified" xlink:type="arc" order="138"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_f8177825-4cf3-427b-83e7-52595eced217NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_f8177825-4cf3-427b-83e7-52595eced217NotDimensionallyQualified" xlink:type="arc" order="139"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_2706e585-d77a-4b55-b78f-1063969e7fd7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashAndCashEquivalents_2706e585-d77a-4b55-b78f-1063969e7fd7NotDimensionallyQualified" xlink:type="arc" order="140"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_2c039998-ba9f-47a0-8684-2aa9f8952757NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_2c039998-ba9f-47a0-8684-2aa9f8952757NotDimensionallyQualified" xlink:type="arc" order="141"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CountryOfIncorporation_9bba48a6-42de-4ce0-9f46-3baadf88fe5fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CountryOfIncorporation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CountryOfIncorporation_9bba48a6-42de-4ce0-9f46-3baadf88fe5fNotDimensionallyQualified" xlink:type="arc" order="142"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DomicileOfEntity_74ae30f0-c6e8-4775-bb77-f4dddf4b30f0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DomicileOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DomicileOfEntity_74ae30f0-c6e8-4775-bb77-f4dddf4b30f0NotDimensionallyQualified" xlink:type="arc" order="143"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfParentEntity_019b02ba-d33d-7dd2-a4df-522e4c24e9e0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NameOfParentEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfParentEntity_019b02ba-d33d-7dd2-a4df-522e4c24e9e0NotDimensionallyQualified" xlink:type="arc" order="144"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LegalFormOfEntity_019b02bd-83a0-7372-81a8-6f6de1c99d36NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LegalFormOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LegalFormOfEntity_019b02bd-83a0-7372-81a8-6f6de1c99d36NotDimensionallyQualified" xlink:type="arc" order="145"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfUltimateParentOfGroup_019b02be-573d-72f4-a98b-46a0c7251618NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NameOfUltimateParentOfGroup"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfUltimateParentOfGroup_019b02be-573d-72f4-a98b-46a0c7251618NotDimensionallyQualified" xlink:type="arc" order="146"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_4df9a326-1a70-45c3-9b6a-0e30a31803b2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AddressOfRegisteredOfficeOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_4df9a326-1a70-45c3-9b6a-0e30a31803b2NotDimensionallyQualified" xlink:type="arc" order="147"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_019c6b76-082c-77b1-b0d5-29de8b946d04NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_019c6b76-082c-77b1-b0d5-29de8b946d04NotDimensionallyQualified" xlink:type="arc" order="148"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PrincipalPlaceOfBusiness_bb3eb51d-b308-4487-805a-abf4583eb8caNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PrincipalPlaceOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PrincipalPlaceOfBusiness_bb3eb51d-b308-4487-805a-abf4583eb8caNotDimensionallyQualified" xlink:type="arc" order="149"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGeneralInformationAboutFinancialStatementsExplanatory_5d300d84-e198-4e0c-a249-f1cfd27e55d9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfGeneralInformationAboutFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGeneralInformationAboutFinancialStatementsExplanatory_5d300d84-e198-4e0c-a249-f1cfd27e55d9NotDimensionallyQualified" xlink:type="arc" order="150"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_f5609eee-9483-471a-ac79-b17042b98b5dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_f5609eee-9483-471a-ac79-b17042b98b5dNotDimensionallyQualified" xlink:type="arc" order="151"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfIFRSCompliance_e4cad143-82fc-4a21-82f5-2be196351501NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfIFRSCompliance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_StatementOfIFRSCompliance_e4cad143-82fc-4a21-82f5-2be196351501NotDimensionallyQualified" xlink:type="arc" order="152"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAuthorisationOfFinancialStatementsExplanatory_d3559349-455b-48b8-951c-e0597ca08918NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAuthorisationOfFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAuthorisationOfFinancialStatementsExplanatory_d3559349-455b-48b8-951c-e0597ca08918NotDimensionallyQualified" xlink:type="arc" order="153"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_ab65ad9c-a192-4948-9a58-97ba4370c310NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_ab65ad9c-a192-4948-9a58-97ba4370c310NotDimensionallyQualified" xlink:type="arc" order="154"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_6eb74ec4-6197-4523-b8f4-4e0827030ae2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBasisOfConsolidationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_6eb74ec4-6197-4523-b8f4-4e0827030ae2NotDimensionallyQualified" xlink:type="arc" order="155"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfInitialApplicationOfStandardsOrInterpretations_0cafb900-59c6-4a1a-9574-21ec4458e476NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfInitialApplicationOfStandardsOrInterpretations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfInitialApplicationOfStandardsOrInterpretations_0cafb900-59c6-4a1a-9574-21ec4458e476NotDimensionallyQualified" xlink:type="arc" order="156"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations_527a309b-fb21-4269-839f-cad119ebdeb8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations_527a309b-fb21-4269-839f-cad119ebdeb8NotDimensionallyQualified" xlink:type="arc" order="157"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBusinessCombinationsExplanatory_8cbc47ef-5701-48c8-8eef-7312cc651f14NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBusinessCombinationsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBusinessCombinationsExplanatory_8cbc47ef-5701-48c8-8eef-7312cc651f14NotDimensionallyQualified" xlink:type="arc" order="158"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_24f8f398-e22e-457e-af01-d06b2feb5182NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_24f8f398-e22e-457e-af01-d06b2feb5182NotDimensionallyQualified" xlink:type="arc" order="159"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_1ed91589-1565-46b5-bcb1-880cf74ea313NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_1ed91589-1565-46b5-bcb1-880cf74ea313NotDimensionallyQualified" xlink:type="arc" order="160"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithRelatedPartiesExplanatory_9f09fcc6-26c6-4a16-8bde-f19adc70d686NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithRelatedPartiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithRelatedPartiesExplanatory_9f09fcc6-26c6-4a16-8bde-f19adc70d686NotDimensionallyQualified" xlink:type="arc" order="161"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsAndGoodwillExplanatory_068d05c5-c5bd-42c0-846d-9ab5b60bb7d0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsAndGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsAndGoodwillExplanatory_068d05c5-c5bd-42c0-846d-9ab5b60bb7d0NotDimensionallyQualified" xlink:type="arc" order="162"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory_c1a30272-e316-438b-920b-acebbff8e32eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory_c1a30272-e316-438b-920b-acebbff8e32eNotDimensionallyQualified" xlink:type="arc" order="163"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory_87b0122f-049a-4914-8178-5cbd1499b75eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory_87b0122f-049a-4914-8178-5cbd1499b75eNotDimensionallyQualified" xlink:type="arc" order="164"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory_04a70958-004d-42fd-ba31-75104fe54794NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory_04a70958-004d-42fd-ba31-75104fe54794NotDimensionallyQualified" xlink:type="arc" order="165"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_a11ae99a-9c09-464a-bf56-88f8ef7b2410NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_a11ae99a-9c09-464a-bf56-88f8ef7b2410NotDimensionallyQualified" xlink:type="arc" order="166"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociatesAndJointVenturesExplanatory_03636fde-d0ce-4c82-b62a-58da1a3fbb34NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociatesAndJointVenturesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociatesAndJointVenturesExplanatory_03636fde-d0ce-4c82-b62a-58da1a3fbb34NotDimensionallyQualified" xlink:type="arc" order="167"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentsInJointVentures_47a75c49-7400-4c3c-a71b-aaa14977bf23NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentsInJointVentures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentsInJointVentures_47a75c49-7400-4c3c-a71b-aaa14977bf23NotDimensionallyQualified" xlink:type="arc" order="168"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_73a46ecc-e942-4232-9631-f0f91b4d6b15NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_73a46ecc-e942-4232-9631-f0f91b4d6b15NotDimensionallyQualified" xlink:type="arc" order="169"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForGoodwillExplanatory_de9e3a43-2408-484a-a785-e1507166c02fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForGoodwillExplanatory_de9e3a43-2408-484a-a785-e1507166c02fNotDimensionallyQualified" xlink:type="arc" order="170"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsAndGoodwillExplanatory_9b60d385-94c7-4665-b50e-345f0d710e6cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsAndGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsAndGoodwillExplanatory_9b60d385-94c7-4665-b50e-345f0d710e6cNotDimensionallyQualified" xlink:type="arc" order="171"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory_30e388e2-1c9d-4c51-87d7-0b61b352f912NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory_30e388e2-1c9d-4c51-87d7-0b61b352f912NotDimensionallyQualified" xlink:type="arc" order="172"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_a7e7c840-9517-44de-81ee-76baa25e1254NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_a7e7c840-9517-44de-81ee-76baa25e1254NotDimensionallyQualified" xlink:type="arc" order="173"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory_b6b00029-9c89-4696-a036-6f06ac37db06NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory_b6b00029-9c89-4696-a036-6f06ac37db06NotDimensionallyQualified" xlink:type="arc" order="174"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_405224f8-3762-4d58-902b-b69946741a4fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_405224f8-3762-4d58-902b-b69946741a4fNotDimensionallyQualified" xlink:type="arc" order="175"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForRepairsAndMaintenanceExplanatory_98b92d33-3eb7-4be6-b13c-21aa54ab80a8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForRepairsAndMaintenanceExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForRepairsAndMaintenanceExplanatory_98b92d33-3eb7-4be6-b13c-21aa54ab80a8NotDimensionallyQualified" xlink:type="arc" order="176"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_cc7301f2-8c25-4d00-92b5-ba25ca1e3d56NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_cc7301f2-8c25-4d00-92b5-ba25ca1e3d56NotDimensionallyQualified" xlink:type="arc" order="177"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_cafc129f-6b8d-4266-a8a2-4a6da2d0eb23NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_cafc129f-6b8d-4266-a8a2-4a6da2d0eb23NotDimensionallyQualified" xlink:type="arc" order="178"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory_45070f0b-eed7-4e35-9b04-60a891b6f51dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory_45070f0b-eed7-4e35-9b04-60a891b6f51dNotDimensionallyQualified" xlink:type="arc" order="179"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_4be00563-ca92-4f80-a609-f8b9286b23c5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_4be00563-ca92-4f80-a609-f8b9286b23c5NotDimensionallyQualified" xlink:type="arc" order="180"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDerecognitionOfFinancialInstrumentsExplanatory_7aa72d1f-5fa7-4a17-ad9b-9678e189232cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDerecognitionOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDerecognitionOfFinancialInstrumentsExplanatory_7aa72d1f-5fa7-4a17-ad9b-9678e189232cNotDimensionallyQualified" xlink:type="arc" order="181"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory_d1c9f7ae-3f49-4d43-aefb-5776634a9565NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory_d1c9f7ae-3f49-4d43-aefb-5776634a9565NotDimensionallyQualified" xlink:type="arc" order="182"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExplanationOfCreditRiskManagementPracticesAndHowTheyRelateToRecognitionAndMeasurementOfExpectedCreditLossesExplanatory_ee22d6c6-9427-449f-98d0-e6d6e1fadc45NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ExplanationOfCreditRiskManagementPracticesAndHowTheyRelateToRecognitionAndMeasurementOfExpectedCreditLossesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ExplanationOfCreditRiskManagementPracticesAndHowTheyRelateToRecognitionAndMeasurementOfExpectedCreditLossesExplanatory_ee22d6c6-9427-449f-98d0-e6d6e1fadc45NotDimensionallyQualified" xlink:type="arc" order="183"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_1ea15770-da1b-43a9-b33e-f7ebf875db73NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_1ea15770-da1b-43a9-b33e-f7ebf875db73NotDimensionallyQualified" xlink:type="arc" order="184"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherPayablesExplanatory_42a4554c-f3c3-4fd0-8db9-ae49229f0de8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherPayablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherPayablesExplanatory_42a4554c-f3c3-4fd0-8db9-ae49229f0de8NotDimensionallyQualified" xlink:type="arc" order="185"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsAndHedgingExplanatory_75d1825c-ac3c-406e-8707-db216891abadNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsAndHedgingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsAndHedgingExplanatory_75d1825c-ac3c-406e-8707-db216891abadNotDimensionallyQualified" xlink:type="arc" order="186"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsExplanatory_021166f9-2c88-46f2-993c-b2ae56bd0924NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsExplanatory_021166f9-2c88-46f2-993c-b2ae56bd0924NotDimensionallyQualified" xlink:type="arc" order="187"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForHedgingExplanatory_df2dc493-de62-4faa-b012-314062b327e8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForHedgingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForHedgingExplanatory_df2dc493-de62-4faa-b012-314062b327e8NotDimensionallyQualified" xlink:type="arc" order="188"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_4c6b5b6a-2d3d-43ad-ba69-2f42e368db88NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_4c6b5b6a-2d3d-43ad-ba69-2f42e368db88NotDimensionallyQualified" xlink:type="arc" order="189"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForMeasuringInventories_1c66995c-acfe-4c7a-9d30-80dde78e8436NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForMeasuringInventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForMeasuringInventories_1c66995c-acfe-4c7a-9d30-80dde78e8436NotDimensionallyQualified" xlink:type="arc" order="190"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyToDetermineComponentsOfCashAndCashEquivalents_625eae66-d56c-4995-9948-a6ebbb8abd58NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyToDetermineComponentsOfCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyToDetermineComponentsOfCashAndCashEquivalents_625eae66-d56c-4995-9948-a6ebbb8abd58NotDimensionallyQualified" xlink:type="arc" order="191"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants_ab16f0e5-d71e-43cb-8992-e0e59d2473abNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants_ab16f0e5-d71e-43cb-8992-e0e59d2473abNotDimensionallyQualified" xlink:type="arc" order="192"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_057cc6ae-e18e-4b59-bc0b-c51df32b2941NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_057cc6ae-e18e-4b59-bc0b-c51df32b2941NotDimensionallyQualified" xlink:type="arc" order="193"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTerminationBenefits_3f1f1049-7d48-4c1e-bc66-5d0715374a39NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForTerminationBenefits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTerminationBenefits_3f1f1049-7d48-4c1e-bc66-5d0715374a39NotDimensionallyQualified" xlink:type="arc" order="194"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_75f33c00-fe56-45f6-aaeb-d9da147135c2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_75f33c00-fe56-45f6-aaeb-d9da147135c2NotDimensionallyQualified" xlink:type="arc" order="195"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_7dab9b6b-cc71-427f-a900-0a7780b01837NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_7dab9b6b-cc71-427f-a900-0a7780b01837NotDimensionallyQualified" xlink:type="arc" order="196"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_6353a275-6d94-4ef7-8d26-0fab4688a2a2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_6353a275-6d94-4ef7-8d26-0fab4688a2a2NotDimensionallyQualified" xlink:type="arc" order="197"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDeferredIncomeTaxExplanatory_ed588caf-d29c-42a8-9528-e7bd03344bd2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDeferredIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDeferredIncomeTaxExplanatory_ed588caf-d29c-42a8-9528-e7bd03344bd2NotDimensionallyQualified" xlink:type="arc" order="198"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForEnvironmentRelatedExpenseExplanatory_f83cedbb-2df0-4789-a810-2330e3aa58ecNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForEnvironmentRelatedExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForEnvironmentRelatedExpenseExplanatory_f83cedbb-2df0-4789-a810-2330e3aa58ecNotDimensionallyQualified" xlink:type="arc" order="199"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_d5fe4417-4bd6-4bf1-86e9-1d4b5eb0d6deNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_d5fe4417-4bd6-4bf1-86e9-1d4b5eb0d6deNotDimensionallyQualified" xlink:type="arc" order="200"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOperatingSegmentsExplanatory_57592f88-23a4-4732-b4bf-0d4d02a7f362NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOperatingSegmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOperatingSegmentsExplanatory_57592f88-23a4-4732-b4bf-0d4d02a7f362NotDimensionallyQualified" xlink:type="arc" order="201"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGeographicalAreasExplanatory_0fc480a8-6ea4-4763-bc15-c9283c4dd6b9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfGeographicalAreasExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGeographicalAreasExplanatory_0fc480a8-6ea4-4763-bc15-c9283c4dd6b9NotDimensionallyQualified" xlink:type="arc" order="202"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSegmentsMajorCustomersExplanatory_ce014943-d637-4400-88dd-13a2ae02f64fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSegmentsMajorCustomersExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSegmentsMajorCustomersExplanatory_ce014943-d637-4400-88dd-13a2ae02f64fNotDimensionallyQualified" xlink:type="arc" order="203"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIntangibleAssetsAndGoodwillExplanatory_3366a316-1c48-4f49-93fa-030b6663e0cbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfIntangibleAssetsAndGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIntangibleAssetsAndGoodwillExplanatory_3366a316-1c48-4f49-93fa-030b6663e0cbNotDimensionallyQualified" xlink:type="arc" order="204"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGoodwillExplanatory_b7e079ce-59b5-478d-b585-39e086d403abNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGoodwillExplanatory_b7e079ce-59b5-478d-b585-39e086d403abNotDimensionallyQualified" xlink:type="arc" order="205"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_a334734b-d573-4f9e-a7b1-76af23dd0800NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_a334734b-d573-4f9e-a7b1-76af23dd0800NotDimensionallyQualified" xlink:type="arc" order="206"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIntangibleAssetsExplanatory_807e496c-12a4-42e2-8530-d372e50d8162NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfIntangibleAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIntangibleAssetsExplanatory_807e496c-12a4-42e2-8530-d372e50d8162NotDimensionallyQualified" xlink:type="arc" order="207"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCommitmentsExplanatory_e47c3474-a9f9-479f-888c-dcc220a2580dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCommitmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCommitmentsExplanatory_e47c3474-a9f9-479f-888c-dcc220a2580dNotDimensionallyQualified" xlink:type="arc" order="208"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfLeasesExplanatory_4dae7571-55a6-4176-be15-33d6f9e54ed2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfLeasesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfLeasesExplanatory_4dae7571-55a6-4176-be15-33d6f9e54ed2NotDimensionallyQualified" xlink:type="arc" order="209"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDepreciationAndAmortisationExpenseExplanatory_0945bda3-3b21-4685-a5e7-42f77dabf1dfNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDepreciationAndAmortisationExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDepreciationAndAmortisationExpenseExplanatory_0945bda3-3b21-4685-a5e7-42f77dabf1dfNotDimensionallyQualified" xlink:type="arc" order="210"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfQuantitativeInformationAboutRightofuseAssetsExplanatory_9b9ab5b2-54d2-41fc-9e72-65269e8f8b61NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfQuantitativeInformationAboutRightofuseAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfQuantitativeInformationAboutRightofuseAssetsExplanatory_9b9ab5b2-54d2-41fc-9e72-65269e8f8b61NotDimensionallyQualified" xlink:type="arc" order="211"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceCostExplanatory_ea5828a9-a363-4172-a86d-ce9082dd45f8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinanceCostExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceCostExplanatory_ea5828a9-a363-4172-a86d-ce9082dd45f8NotDimensionallyQualified" xlink:type="arc" order="212"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_0e560d05-e37b-42f6-b141-2e7cd1826cebNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_0e560d05-e37b-42f6-b141-2e7cd1826cebNotDimensionallyQualified" xlink:type="arc" order="213"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_b3775ec6-ff8a-4348-be7b-b01a7891e00dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_b3775ec6-ff8a-4348-be7b-b01a7891e00dNotDimensionallyQualified" xlink:type="arc" order="214"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory_4ad5b643-497a-47b0-b4d8-47e580a285faNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory_4ad5b643-497a-47b0-b4d8-47e580a285faNotDimensionallyQualified" xlink:type="arc" order="215"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDividendsExplanatory_943a527f-0eee-4f05-abc2-16ed7ad0c0c4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDividendsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDividendsExplanatory_943a527f-0eee-4f05-abc2-16ed7ad0c0c4NotDimensionallyQualified" xlink:type="arc" order="216"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFairValueMeasurementExplanatory_97c8f065-2c6d-4100-89c6-c5801b563e16NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFairValueMeasurementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFairValueMeasurementExplanatory_97c8f065-2c6d-4100-89c6-c5801b563e16NotDimensionallyQualified" xlink:type="arc" order="217"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_0dd03ff8-45ac-414a-b425-ae62d5d5b276NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_0dd03ff8-45ac-414a-b425-ae62d5d5b276NotDimensionallyQualified" xlink:type="arc" order="218"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialAssetsExplanatory_1a6bada7-a144-459e-9533-97ca6a472e4fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialAssetsExplanatory_1a6bada7-a144-459e-9533-97ca6a472e4fNotDimensionallyQualified" xlink:type="arc" order="219"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInventoriesExplanatory_7c35d03f-d000-44cb-b41f-96f54b65a374NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInventoriesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInventoriesExplanatory_7c35d03f-d000-44cb-b41f-96f54b65a374NotDimensionallyQualified" xlink:type="arc" order="220"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialInstrumentsExplanatory_9a269f9b-f435-4e93-9da8-15ebd1c0de19NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialInstrumentsExplanatory_9a269f9b-f435-4e93-9da8-15ebd1c0de19NotDimensionallyQualified" xlink:type="arc" order="221"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTaxReceivablesAndPayablesExplanatory_8aae9559-808d-4efe-af65-e0ab72d0f48eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfTaxReceivablesAndPayablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTaxReceivablesAndPayablesExplanatory_8aae9559-808d-4efe-af65-e0ab72d0f48eNotDimensionallyQualified" xlink:type="arc" order="222"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory_549b8f93-d512-4f6b-a173-bcb0a155051dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory_549b8f93-d512-4f6b-a173-bcb0a155051dNotDimensionallyQualified" xlink:type="arc" order="223"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_c8471fea-a6c3-455b-88c8-6c70d12d8703NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_c8471fea-a6c3-455b-88c8-6c70d12d8703NotDimensionallyQualified" xlink:type="arc" order="224"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRestrictedCashAndCashEquivalentsExplanatory_51abcfba-05dd-40b6-a078-f8d59911d8a1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRestrictedCashAndCashEquivalentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRestrictedCashAndCashEquivalentsExplanatory_51abcfba-05dd-40b6-a078-f8d59911d8a1NotDimensionallyQualified" xlink:type="arc" order="225"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory_e3d119c1-ef03-455b-8bb6-d0d2ed607dcaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory_e3d119c1-ef03-455b-8bb6-d0d2ed607dcaNotDimensionallyQualified" xlink:type="arc" order="226"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_ed95fe48-d0e6-42be-89a0-63c0c825d44dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_ed95fe48-d0e6-42be-89a0-63c0c825d44dNotDimensionallyQualified" xlink:type="arc" order="227"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIssuedCapitalExplanatory_a145677e-756d-4604-9fba-8126b0253d8cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfIssuedCapitalExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIssuedCapitalExplanatory_a145677e-756d-4604-9fba-8126b0253d8cNotDimensionallyQualified" xlink:type="arc" order="228"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfReservesAndOtherEquityInterestExplanatory_5ccf3407-d8ca-414d-b78f-8610f17ca6f8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfReservesAndOtherEquityInterestExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfReservesAndOtherEquityInterestExplanatory_5ccf3407-d8ca-414d-b78f-8610f17ca6f8NotDimensionallyQualified" xlink:type="arc" order="229"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_6ed6f48f-6e18-4f42-a459-731e80956052NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfTreasurySharesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_6ed6f48f-6e18-4f42-a459-731e80956052NotDimensionallyQualified" xlink:type="arc" order="230"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEarningsPerShareExplanatory_d7b493e5-2d73-4021-a323-dd57f9257229NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEarningsPerShareExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEarningsPerShareExplanatory_d7b493e5-2d73-4021-a323-dd57f9257229NotDimensionallyQualified" xlink:type="arc" order="231"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForEarningsPerShareExplanatory_7bb95658-7aa1-4e55-8a17-18d187704c8aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForEarningsPerShareExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForEarningsPerShareExplanatory_7bb95658-7aa1-4e55-8a17-18d187704c8aNotDimensionallyQualified" xlink:type="arc" order="232"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_1a8c9544-d262-4962-b2a0-53545d9a2c2fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_1a8c9544-d262-4962-b2a0-53545d9a2c2fNotDimensionallyQualified" xlink:type="arc" order="233"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_7f3e09a2-8d8d-4d5e-b889-c9de8d059e77NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_7f3e09a2-8d8d-4d5e-b889-c9de8d059e77NotDimensionallyQualified" xlink:type="arc" order="234"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfProvisionsExplanatory_84841004-4945-4ab6-a712-71f3bb5b20f4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfProvisionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfProvisionsExplanatory_84841004-4945-4ab6-a712-71f3bb5b20f4NotDimensionallyQualified" xlink:type="arc" order="235"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDebtSecuritiesExplanatory_4f6fe5cc-289d-4f15-8cd0-2f840b2e2ff8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDebtSecuritiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDebtSecuritiesExplanatory_4f6fe5cc-289d-4f15-8cd0-2f840b2e2ff8NotDimensionallyQualified" xlink:type="arc" order="236"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialLiabilitiesExplanatory_21c9f552-ecef-439b-aa99-274244ea21aaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinancialLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialLiabilitiesExplanatory_21c9f552-ecef-439b-aa99-274244ea21aaNotDimensionallyQualified" xlink:type="arc" order="237"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEffectOfChangesInForeignExchangeRatesExplanatory_9805eba7-92d5-4685-87f4-127e7f9de616NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEffectOfChangesInForeignExchangeRatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEffectOfChangesInForeignExchangeRatesExplanatory_9805eba7-92d5-4685-87f4-127e7f9de616NotDimensionallyQualified" xlink:type="arc" order="238"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_7c0b4223-2b7c-4369-bffe-9e400f403fe7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBorrowingsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_7c0b4223-2b7c-4369-bffe-9e400f403fe7NotDimensionallyQualified" xlink:type="arc" order="239"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesExplanatory_d31a0ce3-c834-46a5-8963-45ab951a1e70NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfReconciliationOfLiabilitiesArisingFromFinancingActivitiesExplanatory_d31a0ce3-c834-46a5-8963-45ab951a1e70NotDimensionallyQualified" xlink:type="arc" order="240"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherLiabilitiesExplanatory_7cb4e5ea-f7f9-499c-9b17-4c62452935a3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherLiabilitiesExplanatory_7cb4e5ea-f7f9-499c-9b17-4c62452935a3NotDimensionallyQualified" xlink:type="arc" order="241"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory_7903d64f-7628-4d7b-bdba-3550a77975beNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory_7903d64f-7628-4d7b-bdba-3550a77975beNotDimensionallyQualified" xlink:type="arc" order="242"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory_7b131ead-9ce2-43c2-a0e1-5c7d255212e3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory_7b131ead-9ce2-43c2-a0e1-5c7d255212e3NotDimensionallyQualified" xlink:type="arc" order="243"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRevenueExplanatory_df0d5382-fc4c-479f-a861-efed1e6af7dbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRevenueExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRevenueExplanatory_df0d5382-fc4c-479f-a861-efed1e6af7dbNotDimensionallyQualified" xlink:type="arc" order="244"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEmployeeBenefitsExplanatory_2a95d820-f0f8-4f65-86b4-107df088083aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEmployeeBenefitsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEmployeeBenefitsExplanatory_2a95d820-f0f8-4f65-86b4-107df088083aNotDimensionallyQualified" xlink:type="arc" order="245"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfExpensesExplanatory_73193063-f0e8-43c0-abfe-aa510bf64da1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfExpensesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfExpensesExplanatory_73193063-f0e8-43c0-abfe-aa510bf64da1NotDimensionallyQualified" xlink:type="arc" order="246"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfExpensesByNatureExplanatory_75784439-11f8-46dc-a614-90100bc17116NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfExpensesByNatureExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfExpensesByNatureExplanatory_75784439-11f8-46dc-a614-90100bc17116NotDimensionallyQualified" xlink:type="arc" order="247"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGeneralAndAdministrativeExpenseExplanatory_e76b27b6-73b5-4096-bba0-927bdbceffccNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfGeneralAndAdministrativeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGeneralAndAdministrativeExpenseExplanatory_e76b27b6-73b5-4096-bba0-927bdbceffccNotDimensionallyQualified" xlink:type="arc" order="248"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory_d4993996-f5ee-48bd-b8b2-98068c243b64NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory_d4993996-f5ee-48bd-b8b2-98068c243b64NotDimensionallyQualified" xlink:type="arc" order="249"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfResearchAndDevelopmentExpenseExplanatory_48ff2734-73c1-4e56-aed2-a43f3be03711NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfResearchAndDevelopmentExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfResearchAndDevelopmentExpenseExplanatory_48ff2734-73c1-4e56-aed2-a43f3be03711NotDimensionallyQualified" xlink:type="arc" order="250"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFeeAndCommissionIncomeExpenseExplanatory_25392f8c-c4d6-47c7-9288-9942ac126562NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFeeAndCommissionIncomeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFeeAndCommissionIncomeExpenseExplanatory_25392f8c-c4d6-47c7-9288-9942ac126562NotDimensionallyQualified" xlink:type="arc" order="251"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory_2679df2b-4d04-417d-816a-9da8efddccd1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory_2679df2b-4d04-417d-816a-9da8efddccd1NotDimensionallyQualified" xlink:type="arc" order="252"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherOperatingIncomeExpenseExplanatory_22ba5955-006b-4f63-b686-aca7b2c7c01aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherOperatingIncomeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherOperatingIncomeExpenseExplanatory_22ba5955-006b-4f63-b686-aca7b2c7c01aNotDimensionallyQualified" xlink:type="arc" order="253"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInterestIncomeExpenseExplanatory_32693d4e-aab1-47ca-aa36-c347b0bc096cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInterestIncomeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInterestIncomeExpenseExplanatory_32693d4e-aab1-47ca-aa36-c347b0bc096cNotDimensionallyQualified" xlink:type="arc" order="254"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBorrowingCostsExplanatory_33f67c47-5892-42e1-a115-529be2f98263NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBorrowingCostsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBorrowingCostsExplanatory_33f67c47-5892-42e1-a115-529be2f98263NotDimensionallyQualified" xlink:type="arc" order="255"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInterestExpenseExplanatory_865d4cd8-2858-474b-8242-3f744d8b9ff9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInterestExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInterestExpenseExplanatory_865d4cd8-2858-474b-8242-3f744d8b9ff9NotDimensionallyQualified" xlink:type="arc" order="256"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_044e957e-e1dd-4a6c-8a32-4e699d432b2eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_044e957e-e1dd-4a6c-8a32-4e699d432b2eNotDimensionallyQualified" xlink:type="arc" order="257"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInterestIncomeExplanatory_5dde52a0-f5c7-46a6-b2c1-451a75d195d7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInterestIncomeExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInterestIncomeExplanatory_5dde52a0-f5c7-46a6-b2c1-451a75d195d7NotDimensionallyQualified" xlink:type="arc" order="258"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDefinedBenefitPlansExplanatory_019b07fd-e6f7-71a3-bfcc-76dc380abbbdNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDefinedBenefitPlansExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDefinedBenefitPlansExplanatory_019b07fd-e6f7-71a3-bfcc-76dc380abbbdNotDimensionallyQualified" xlink:type="arc" order="259"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAdditionalInformationAboutDefinedBenefitPlansExplanatory_019b0802-70e7-718a-8747-c142e8fa8eadNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAdditionalInformationAboutDefinedBenefitPlansExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAdditionalInformationAboutDefinedBenefitPlansExplanatory_019b0802-70e7-718a-8747-c142e8fa8eadNotDimensionallyQualified" xlink:type="arc" order="260"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_b25e8e9a-5158-40d1-b668-ed3cae8841e4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_b25e8e9a-5158-40d1-b668-ed3cae8841e4NotDimensionallyQualified" xlink:type="arc" order="261"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDeferredTaxesExplanatory_99aed1d6-63e9-4e7b-9ae1-1c3c2d163c7fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDeferredTaxesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDeferredTaxesExplanatory_99aed1d6-63e9-4e7b-9ae1-1c3c2d163c7fNotDimensionallyQualified" xlink:type="arc" order="262"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfContingentLiabilitiesExplanatory_4aa0b7f2-e0a4-4f47-88ff-f1936fd36b08NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfContingentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfContingentLiabilitiesExplanatory_4aa0b7f2-e0a4-4f47-88ff-f1936fd36b08NotDimensionallyQualified" xlink:type="arc" order="263"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_7c102712-def1-41c9-9e16-d96084cd85e5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_7c102712-def1-41c9-9e16-d96084cd85e5NotDimensionallyQualified" xlink:type="arc" order="264"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherProvisionsContingentLiabilitiesAndContingentAssetsExplanatory_582e4c78-0394-4c59-bb2d-343e22410057NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherProvisionsContingentLiabilitiesAndContingentAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherProvisionsContingentLiabilitiesAndContingentAssetsExplanatory_582e4c78-0394-4c59-bb2d-343e22410057NotDimensionallyQualified" xlink:type="arc" order="265"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCollateralExplanatory_636d1f31-74a9-4af1-a6ca-168078b4f886NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCollateralExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCollateralExplanatory_636d1f31-74a9-4af1-a6ca-168078b4f886NotDimensionallyQualified" xlink:type="arc" order="266"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_00a53bcd-136d-4c7b-98a5-6f44e45d0206NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_00a53bcd-136d-4c7b-98a5-6f44e45d0206NotDimensionallyQualified" xlink:type="arc" order="267"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCreditRiskExplanatory_03477bf8-c42e-464a-ae09-e52903218082NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCreditRiskExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCreditRiskExplanatory_03477bf8-c42e-464a-ae09-e52903218082NotDimensionallyQualified" xlink:type="arc" order="268"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCreditRiskExposureExplanatory_89f15250-70e9-45fe-9130-faeae47b03daNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCreditRiskExposureExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCreditRiskExposureExplanatory_89f15250-70e9-45fe-9130-faeae47b03daNotDimensionallyQualified" xlink:type="arc" order="269"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAllowanceForCreditLossesExplanatory_ac4c4e77-bd9a-4666-aee0-0cbab90654a1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAllowanceForCreditLossesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAllowanceForCreditLossesExplanatory_ac4c4e77-bd9a-4666-aee0-0cbab90654a1NotDimensionallyQualified" xlink:type="arc" order="270"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfLiquidityRiskExplanatory_1e01a107-2e8e-4203-be2e-fd67fd46a56eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfLiquidityRiskExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfLiquidityRiskExplanatory_1e01a107-2e8e-4203-be2e-fd67fd46a56eNotDimensionallyQualified" xlink:type="arc" order="271"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfManagingLiquidityRisk_70cc7401-6eaf-44d3-96e1-8956a087d4b6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfManagingLiquidityRisk"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfManagingLiquidityRisk_70cc7401-6eaf-44d3-96e1-8956a087d4b6NotDimensionallyQualified" xlink:type="arc" order="272"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfMarketRiskExplanatory_ec63b1f1-5f96-4dae-b723-a78892353f2fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfMarketRiskExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfMarketRiskExplanatory_ec63b1f1-5f96-4dae-b723-a78892353f2fNotDimensionallyQualified" xlink:type="arc" order="273"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SensitivityAnalysisForEachTypeOfMarketRisk_cf48a7ac-8efe-47d0-92ca-f4be5311c2e4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SensitivityAnalysisForEachTypeOfMarketRisk"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_SensitivityAnalysisForEachTypeOfMarketRisk_cf48a7ac-8efe-47d0-92ca-f4be5311c2e4NotDimensionallyQualified" xlink:type="arc" order="274"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDerivativeFinancialInstrumentsExplanatory_23243bb3-8a7d-4850-ad7c-c1419933f298NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDerivativeFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDerivativeFinancialInstrumentsExplanatory_23243bb3-8a7d-4850-ad7c-c1419933f298NotDimensionallyQualified" xlink:type="arc" order="275"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRiskManagementStrategyRelatedToHedgeAccountingExplanatory_fabd85d4-93ec-4278-abff-284eb6fc78e9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRiskManagementStrategyRelatedToHedgeAccountingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRiskManagementStrategyRelatedToHedgeAccountingExplanatory_fabd85d4-93ec-4278-abff-284eb6fc78e9NotDimensionallyQualified" xlink:type="arc" order="276"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_7fd5a239-88c3-4ae7-a9bb-0792937fae56NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinancialRiskManagementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_7fd5a239-88c3-4ae7-a9bb-0792937fae56NotDimensionallyQualified" xlink:type="arc" order="277"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfObjectivesPoliciesAndProcessesForManagingCapitalExplanatory_b8a0e60d-64a2-4a7c-a20e-46dc90a5a58bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfObjectivesPoliciesAndProcessesForManagingCapitalExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfObjectivesPoliciesAndProcessesForManagingCapitalExplanatory_b8a0e60d-64a2-4a7c-a20e-46dc90a5a58bNotDimensionallyQualified" xlink:type="arc" order="278"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory_500f960d-73d4-4723-b9bd-15950b5a004aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory_500f960d-73d4-4723-b9bd-15950b5a004aNotDimensionallyQualified" xlink:type="arc" order="279"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory_bf8cc6f0-eee2-4ff8-b677-cc6e4815f9aeNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory_bf8cc6f0-eee2-4ff8-b677-cc6e4815f9aeNotDimensionallyQualified" xlink:type="arc" order="280"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRelatedPartyExplanatory_248a9d17-9153-4d63-b5d1-88e8c8b30e6aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRelatedPartyExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRelatedPartyExplanatory_248a9d17-9153-4d63-b5d1-88e8c8b30e6aNotDimensionallyQualified" xlink:type="arc" order="281"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceIncomeExplanatory_c018473f-3e92-44fd-b8b2-0ee90da9aebdNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinanceIncomeExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceIncomeExplanatory_c018473f-3e92-44fd-b8b2-0ee90da9aebdNotDimensionallyQualified" xlink:type="arc" order="282"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_RevelacionSobreTemasMedioambientalesTextBlock_c8813cc0-58b3-4cba-880e-dccd8958739dNotDimensionallyQualified" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_RevelacionSobreTemasMedioambientalesTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_grfs_RevelacionSobreTemasMedioambientalesTextBlock_c8813cc0-58b3-4cba-880e-dccd8958739dNotDimensionallyQualified" xlink:type="arc" order="283"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAuditorsRemunerationExplanatory_c1ef0ce0-ac65-43ea-bdf0-5c5fc7736c27NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAuditorsRemunerationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAuditorsRemunerationExplanatory_c1ef0ce0-ac65-43ea-bdf0-5c5fc7736c27NotDimensionallyQualified" xlink:type="arc" order="284"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_5e6cfe8e-8caf-4236-8327-434dae91176aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_5e6cfe8e-8caf-4236-8327-434dae91176aNotDimensionallyQualified" xlink:type="arc" order="285"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_1762e49d-703f-4d49-8392-1f2b31b51206NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_1762e49d-703f-4d49-8392-1f2b31b51206NotDimensionallyQualified" xlink:type="arc" order="286"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.grifols.com/role/Anchoring" xlink:type="simple" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#Anchoring"/>
  <link:definitionLink xlink:role="http://www.grifols.com/role/Anchoring" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_grfs_AdquisicionDeParticipacionesNoDominantes_019c2833-2a83-7727-b9a9-0537f2ae7168" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_AdquisicionDeParticipacionesNoDominantes"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_grfs_AdquisicionDeParticipacionesNoDominantes_019c2833-2a83-7727-b9a9-0537f2ae7168" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_AjusteALasReservasDistribucionDeLosBeneficiosDelAnoAnterior_cfd0367f-672b-4d8f-b071-f890dbbddf16" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_AjusteALasReservasDistribucionDeLosBeneficiosDelAnoAnterior"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParentRelatingToPriorYears" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParentRelatingToPriorYears"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParentRelatingToPriorYears" xlink:to="loc_grfs_AjusteALasReservasDistribucionDeLosBeneficiosDelAnoAnterior_cfd0367f-672b-4d8f-b071-f890dbbddf16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_CobrosPorDesinversiones_845fe3a4-009f-4781-92f9-d340234fd42f" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_CobrosPorDesinversiones"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InflowsOfCashFromInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InflowsOfCashFromInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_InflowsOfCashFromInvestingActivities" xlink:to="loc_grfs_CobrosPorDesinversiones_845fe3a4-009f-4781-92f9-d340234fd42f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero_cb0ff7f0-884b-4fdb-83b8-cd64a8b49aa5" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero_cb0ff7f0-884b-4fdb-83b8-cd64a8b49aa5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero_cb0ff7f0-884b-4fdb-83b8-cd64a8b49aa5" xlink:to="loc_ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_CobrosYPagosPorInstrumentosDePasivoFinanciero_cb0ff7f0-884b-4fdb-83b8-cd64a8b49aa5" xlink:to="loc_ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_CompraDeOtrosActivosFinancieros_b09041a9-cf78-4077-850d-fbab7461ae1a" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_CompraDeOtrosActivosFinancieros"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities" xlink:to="loc_grfs_CompraDeOtrosActivosFinancieros_b09041a9-cf78-4077-850d-fbab7461ae1a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones_e8ebaf00-575f-4a92-b3be-adfdc8f0775b" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherAdjustmentsToReconcileProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss" xlink:to="loc_grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones_e8ebaf00-575f-4a92-b3be-adfdc8f0775b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones_e8ebaf00-575f-4a92-b3be-adfdc8f0775b" xlink:to="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForProvisions" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForProvisions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_DeterioroDeActivosYDotacionesNetasDeProvisiones_e8ebaf00-575f-4a92-b3be-adfdc8f0775b" xlink:to="loc_ifrs-full_AdjustmentsForProvisions" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_DiferenciasDeConversion_3c87aa42-a676-4539-8902-685202c507e1" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_DiferenciasDeConversion"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherComprehensiveIncome" xlink:to="loc_grfs_DiferenciasDeConversion_3c87aa42-a676-4539-8902-685202c507e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfOtherComprehensiveIncomeOfAssociatesAndJointVenturesAccountedForUsingEquityMethodThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ShareOfOtherComprehensiveIncomeOfAssociatesAndJointVenturesAccountedForUsingEquityMethodThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_DiferenciasDeConversion_3c87aa42-a676-4539-8902-685202c507e1" xlink:to="loc_ifrs-full_ShareOfOtherComprehensiveIncomeOfAssociatesAndJointVenturesAccountedForUsingEquityMethodThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_DiferenciasDeConversion_3c87aa42-a676-4539-8902-685202c507e1" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_DividendoACuenta_019c7090-77aa-7d03-9448-dba47a106c87" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_DividendoACuenta"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent" xlink:to="loc_grfs_DividendoACuenta_019c7090-77aa-7d03-9448-dba47a106c87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_EfectivoYOtrosMediosLiquidosEquivalentes_703b1826-70c5-4691-95b9-96022d5cf51e" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_EfectivoYOtrosMediosLiquidosEquivalentes"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CurrentAssets" xlink:to="loc_grfs_EfectivoYOtrosMediosLiquidosEquivalentes_703b1826-70c5-4691-95b9-96022d5cf51e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_GananciasPerdidasEnLaValoracionDePlanesDeBeneficiosDefinidos_778b28d4-fa64-4f8a-bd31-468d26aef66b" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_GananciasPerdidasEnLaValoracionDePlanesDeBeneficiosDefinidos"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax" xlink:to="loc_grfs_GananciasPerdidasEnLaValoracionDePlanesDeBeneficiosDefinidos_778b28d4-fa64-4f8a-bd31-468d26aef66b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_InmovilizadoMaterialEIntangible_80ccc2f6-d7b3-4a29-bff0-097d68ff65b3" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_InmovilizadoMaterialEIntangible"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets" xlink:to="loc_grfs_InmovilizadoMaterialEIntangible_80ccc2f6-d7b3-4a29-bff0-097d68ff65b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_InmovilizadoMaterialEIntangible_80ccc2f6-d7b3-4a29-bff0-097d68ff65b3" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_grfs_InmovilizadoMaterialEIntangible_80ccc2f6-d7b3-4a29-bff0-097d68ff65b3" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OperacionesConSociosOPropietarios_d6f634c0-d6ff-46f8-8386-73aa2d49c6b0" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OperacionesConSociosOPropietarios"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ChangesInEquity" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ChangesInEquity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_grfs_OperacionesConSociosOPropietarios_d6f634c0-d6ff-46f8-8386-73aa2d49c6b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalAcumuladoExcluyendoLasCoberturasDeFlujosDeEfectivo_73086365-0c99-42f7-8206-b3683bfc776b" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalAcumuladoExcluyendoLasCoberturasDeFlujosDeEfectivo"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AccumulatedOtherComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AccumulatedOtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AccumulatedOtherComprehensiveIncome" xlink:to="loc_grfs_OtroResultadoGlobalAcumuladoExcluyendoLasCoberturasDeFlujosDeEfectivo_73086365-0c99-42f7-8206-b3683bfc776b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalDerivadoDeLaValoracionDeInstrumentosFinancieros_019c437c-f863-715f-8632-e4eab2d24364" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalDerivadoDeLaValoracionDeInstrumentosFinancieros"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AccumulatedOtherComprehensiveIncome" xlink:to="loc_grfs_OtroResultadoGlobalDerivadoDeLaValoracionDeInstrumentosFinancieros_019c437c-f863-715f-8632-e4eab2d24364" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtroResultadoGlobalNetoDeImpuestosOtros_a53f5307-4ff5-4173-8bbf-62325eba14de" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtroResultadoGlobalNetoDeImpuestosOtros"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:to="loc_grfs_OtroResultadoGlobalNetoDeImpuestosOtros_a53f5307-4ff5-4173-8bbf-62325eba14de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtrosCobrosDeActividadesDeFinanciacion_d9b6387a-991c-41ce-85f3-af1547687212" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtrosCobrosDeActividadesDeFinanciacion"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_grfs_OtrosCobrosDeActividadesDeFinanciacion_d9b6387a-991c-41ce-85f3-af1547687212" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_OtrosCobrosPagos_d2e134a6-fd15-48b4-ae4d-3ad459b25c0a" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_OtrosCobrosPagos"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities" xlink:to="loc_grfs_OtrosCobrosPagos_d2e134a6-fd15-48b4-ae4d-3ad459b25c0a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PagosPorDividendosYRemuneracionesDeOtrosInstrumentosDePatrimonio_f88d56be-70a7-4268-af39-cd191f1f6bef" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PagosPorDividendosYRemuneracionesDeOtrosInstrumentosDePatrimonio"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_grfs_PagosPorDividendosYRemuneracionesDeOtrosInstrumentosDePatrimonio_f88d56be-70a7-4268-af39-cd191f1f6bef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PagosPorInversiones_4337c6e5-db66-4c1c-9c57-ee448b77868e" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PagosPorInversiones"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OutflowsOfCashFromInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OutflowsOfCashFromInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OutflowsOfCashFromInvestingActivities" xlink:to="loc_grfs_PagosPorInversiones_4337c6e5-db66-4c1c-9c57-ee448b77868e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PorCoberturaDeFlujosDeEfectivoTransferenciaEnLaCuentaDePerdidasYGanancias_9bde1cfa-6f37-4882-8c92-50c3098bfb2e" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PorCoberturaDeFlujosDeEfectivoTransferenciaEnLaCuentaDePerdidasYGanancias"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax" xlink:to="loc_grfs_PorCoberturaDeFlujosDeEfectivoTransferenciaEnLaCuentaDePerdidasYGanancias_9bde1cfa-6f37-4882-8c92-50c3098bfb2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_PorCoberturaDeflujosDeEfectivoIngresosYGastosImputadosDirectamenteAlPatrimonioNeto_4c899cc9-9a23-4fdc-b0fd-00c625795e88" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_PorCoberturaDeflujosDeEfectivoIngresosYGastosImputadosDirectamenteAlPatrimonioNeto"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax" xlink:to="loc_grfs_PorCoberturaDeflujosDeEfectivoIngresosYGastosImputadosDirectamenteAlPatrimonioNeto_4c899cc9-9a23-4fdc-b0fd-00c625795e88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ProductoDeLaVentaDeOtrosActivosFinancieros_040506cc-932f-47b8-964a-e03d5f57ce4e" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ProductoDeLaVentaDeOtrosActivosFinancieros"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities" xlink:to="loc_grfs_ProductoDeLaVentaDeOtrosActivosFinancieros_040506cc-932f-47b8-964a-e03d5f57ce4e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ReservaDeOtrosIngresosIntegralesDiversos_2ea135fe-bb27-41ba-8a15-35f51dfb31f4" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ReservaDeOtrosIngresosIntegralesDiversos"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AccumulatedOtherComprehensiveIncome" xlink:to="loc_grfs_ReservaDeOtrosIngresosIntegralesDiversos_2ea135fe-bb27-41ba-8a15-35f51dfb31f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_Reservas_aebd8676-7ed8-44c3-85f8-a27d2f2231d1" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_Reservas"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_Equity" xlink:to="loc_grfs_Reservas_aebd8676-7ed8-44c3-85f8-a27d2f2231d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacion_52311951-6709-41cc-b911-3c9ae6e31ad2" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacion"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod" xlink:to="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacion_52311951-6709-41cc-b911-3c9ae6e31ad2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacionConActividadSimilarALaDelGrupo_d6dc688d-ceac-4c8c-b5f2-f6aa3c9707aa" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacionConActividadSimilarALaDelGrupo"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod" xlink:to="loc_grfs_ResultadoDeEntidadesValoradasPorElMetodoDeLaParticipacionConActividadSimilarALaDelGrupo_d6dc688d-ceac-4c8c-b5f2-f6aa3c9707aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoDelEjercicioAtribuidoALaSociedadDominante_95d212fc-3b73-4010-a887-e5d7ac36e806" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoDelEjercicioAtribuidoALaSociedadDominante"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent" xlink:to="loc_grfs_ResultadoDelEjercicioAtribuidoALaSociedadDominante_95d212fc-3b73-4010-a887-e5d7ac36e806" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_ResultadoGlobalTotalDelEjercicio_d64a5771-9f83-470e-964a-b69e26715ee0" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_ResultadoGlobalTotalDelEjercicio"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ComprehensiveIncome" xlink:to="loc_grfs_ResultadoGlobalTotalDelEjercicio_d64a5771-9f83-470e-964a-b69e26715ee0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_SubvencionesImputadasAlResultado_39db05d0-6723-4317-b0a9-517fc2d98b2a" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_SubvencionesImputadasAlResultado"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss" xlink:to="loc_grfs_SubvencionesImputadasAlResultado_39db05d0-6723-4317-b0a9-517fc2d98b2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_VariacionDeOtrosActivosFinancierosCorrientesYOtrosActivosCorrientes_2d01bbd6-77b6-460d-9a0a-d4142633030f" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_VariacionDeOtrosActivosFinancierosCorrientesYOtrosActivosCorrientes"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital" xlink:to="loc_grfs_VariacionDeOtrosActivosFinancierosCorrientesYOtrosActivosCorrientes_2d01bbd6-77b6-460d-9a0a-d4142633030f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_VariacionDeValorRazonableEnInstrumentosFinancieros_20277f9c-2a34-439d-93b2-645078c43966" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_VariacionDeValorRazonableEnInstrumentosFinancieros"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherGainsLosses" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherGainsLosses" xlink:to="loc_grfs_VariacionDeValorRazonableEnInstrumentosFinancieros_20277f9c-2a34-439d-93b2-645078c43966" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_grfs_VentaDeActivosACosteAmortizado_b38d6088-f0bf-46d7-a5ca-81a6f4ebd44e" xlink:href="959800HSSNXWRKBK4N60-2025-12-31.xsd#grfs_VentaDeActivosACosteAmortizado"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_FinanceIncomeCost" xlink:to="loc_grfs_VentaDeActivosACosteAmortizado_b38d6088-f0bf-46d7-a5ca-81a6f4ebd44e" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
