Annuꢀl Report  
2022  
Enꢀblꢁnꢂ ꢁntrꢀcellulꢀr delꢁverꢃ  
 
Enabling intracellular delivery  
CONTENTS  
1. Introduction  
a. About PCI Biotech  
b. Our platform technology  
c. Business areas  
2. Board of Directors report  
3. Responsibility statement from the Board of Directors and CEO  
4. Annual statement on corporate governance policy and  
corporate social responsibility policy and the Transparency Act  
5. Financial statements  
6. Auditors report  
7. Other information  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
INTRODUCTION  
ABOUT PCI BIOTECH  
PCI Biotech Holding ASA (“PCI Biotech” or “the Group” or “the Company”) is a biopharmaceutical
company headquartered in Norway and listed on the Oslo Stock Exchange. The company develops
novel therapies through its proprietary photochemical internalisation (PCI) platform technology  
originating from world-leading research at the Oslo University Hospital – the Norwegian Radium  
Hospital. PCI Biotech’s lead product candidate is the photosensitiser fimaporfin (Amphinex®). The PCI  
technology works by inducing light-triggered endosomal release, which may unlock the potential of a  
wide array of modalities.  
OUR PLATFORM TECHNOLOGY  
Several novel classes of drugs (e.g. certain immunotherapeutics) need access to the inside of their  
human target cells, such as tumour cells or immune cells, in order to be effective. Unfortunately, many  
of these substances are by nature encapsulated in so-called endosomes as they enter the target cell.  
Once inside the cell, most of the active compound may hence be trapped in the endosomes and  
therefore unable to exert its therapeutic effect.  
Pharmaceutical companies struggle to find effective methods to release drugs that are entrapped in  
this way and are actively searching for technologies that provide adequate drug release inside the  
target cells, in order to achieve the full therapeutic and commercial potential of their products.  
The PCI technology platform consists of two elements: a proprietary small molecule photosensitiser  
(named fimaporfin) and a light source. The primary aim of PCI is to introduce drug molecules or  
macromolecules into the cytosol of the target cells, called intracellular delivery, in a targeted manner.  
PCI is employed to give the cells new properties by modifying the intracellular trafficking of  
drugs/antigens, leading to enhanced biological effect of these substances after PCI treatment of target  
cells in the body.  
BUSINESS AREA  
fimaNAC - DELIVERY OF NUCLEIC ACID THERAPEUTICS  
Nucleic acids have in recent years emerged as a promising class of drugs, exemplified by the mRNA  
COVID-19 vaccines and several products for the treatment of rare diseases. However, efficient and  
safe delivery to most tissues is still a major barrier to treating new indications. By achieving site-  
directed intracellular delivery, this is a challenge fimaNAC is uniquely positioned to solve. Thus, results  
from collaborations and PCI Biotech’s own data indicate that the fimaNAC technology provides an  
attractive intracellular delivery solution in this area.  
The fimaNAC programme is a preclinical-stage collaborative programme developing a targeted  
intracellular delivery technology for different classes of nucleic acids. PCI Biotech aims to develop the  
fimaNAC technology as a platform for both dermatology and bioprocessing, with a partnership-driven  
development strategy.  
Dermatology  
Systemic nucleic acid delivery to skin is largely ineffective. Needle-based delivery may in some cases  
be effective, but is pharmaceutically sub-optimal and technically cumbersome, especially when larger  
surface areas are involved. PCI Biotech aims to develop a topical formulation for delivery of nucleic  
acid therapeutics to skin using fimaNAC, to combine the ease of use of topical administration with  
enhanced delivery from fimaNAC. Pre-clinical experiments have demonstrated that the fimaNAC  
technology can substantially enhance nucleic acid delivery to skin. PCI Biotech’s development plans  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
focus on chronic skin ulcers, with a large unmet medical need, but the technology may also be applied  
to other dermatological conditions.  
Bioprocessing  
Bioprocessing is the manufacturing of biologic drugs ("biologics"). This involves complex processes  
and bottlenecks in the endeavour to offer breakthrough therapies to new and larger patient  
populations. There is a great need for technologies that enable more effective bioprocessing with  
higher yield as well as increased quality at a lower cost, and PCI Biotech initiated in 2022 a project  
aimed at solving such challenges in viral vector manufacturing by employing the fimaNAC technology.  
Development of bioprocessing technologies is less complex from a regulatory perspective compared  
to development of new therapies, allowing shorter timelines and lower costs of development.  
IMMUNOTHERAPY AND fimaVACC  
The fimaVACC technology aims to enhance immunotherapy responses and has shown excellent  
preclinical efficacy with protein- and peptide-based vaccines. The technology has shown particularly  
strong CD8 T-cell responses, which are important for therapeutic vaccination, as well as enhanced  
helper (CD4) T-cell and antibody responses. Immune responses and safety have been successfully  
translated to healthy subjects in a Ph I clinical study1. The technology is versatile, as it can potentially  
be used with several modalities, including nucleic acid-based immunotherapy.  
Intratumoural immunotherapy  
Immunotherapy utilises the body’s own immune system to fight cancer, and immune checkpoint  
inhibitors (ICIs) have revolutionised cancer treatment. However, a large proportion of patients do not  
respond to ICIs, or progress shortly after initial response. Combining ICIs with intratumour  
immunotherapy is an attractive approach to increase the response rate to ICIs. Here immunotherapy is  
administered directly into the tumour and constitutes a “local” treatment. As a result, the dose is  
relatively low, and systemic adverse effects are expected to be limited, which in turn may enable novel  
combination treatments.  
fimaVACC is a technology designed for local enhancement of therapeutic effects and is well suited for  
delivery of immunotherapy combinations to tumour sites. As such, fimaVACC can enhance the delivery  
of proteins, nucleic acids, small molecules, and viral vectors, all of which are relevant for locally  
administered immunotherapy. In addition, the fimaVACC technology by itself has a local  
immunostimulatory effect, e.g. by inducing cytokine production.  
1 Otterhaug et al. (2021) Frontiers in Immunology;11:576756  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
BOARD OF DIRECTORS REPORT  
A TRANSFORMING YEAR  
The RELEASE trial was terminated in Q1 2022, due to changes in the competitive landscape that  
rendered the trial challenging to complete and potentially inadequate for approval. PCI Biotech  
focussed on a swift and cost-efficient closing process of the RELEASE trial, including tailoring the  
organisation to the new setting with closure of the fimaCHEM program. All major study closure activities  
for the RELEASE trial are completed and the estimated remaining cash effect for 2023 is less than  
NOK -1 million.  
Efforts to finance a Ph II clinical trial in head and neck cancer did not, under the 2022 capital market  
conditions, result in a feasible way forward and the company reported in August that it will not conduct  
a company-sponsored Ph II trial with the fimaVACC technology. This entailed a full downsizing of the  
clinical team, which was enacted during the second half of 2022, with full cost reduction effect in Q1  
2023.  
The year-end cash position of NOK 57 million enables an extended estimated financial runway  
towards the end of 2024 with current plans, providing an opportunity window to demonstrate the  
commercial potential of the technology platform. The company will continue to explore financing and  
strategic opportunities as the pre-clinical pipeline matures.  
2022 was transformative for PCI Biotech. The company now directs its efforts and resources on pre-  
clinical research in areas where there is need for novel drug delivery systems, with a partnership-  
driven development strategy. fimaNAC is focussed on dermatology and bioprocessing applications,  
and fimaVACC on intratumoural immunotherapy.  
In 2022 we initiated a project within bioprocessing, aimed at using fimaNAC for improving yields in  
viral vector manufacturing. Inadequate yield is a bottleneck to making certain gene therapies available  
to new indications and larger patient populations. Development of bioprocessing technologies is less  
complex from a regulatory perspective compared to development of new therapies, allowing shorter  
timelines and lower costs. A first patent application was filed in 2H 2022 and 1H 2023 will be focussed  
on in-house generation of proof-of-principle data at a small scale. Initial external feedback on  
fimaNAC’s value proposition has been positive, warranting further studies working towards testing with  
potential customers.  
Nucleic acid therapeutics have the potential to improve treatment of dermatological diseases, but  
delivery remains an obstacle. PCI Biotech has initiated a project aimed at developing an easy-to-use  
topical formulation for efficacious delivery of nucleic acids using fimaNAC. Readout from the feasibility  
study for the dermatology program, performed by a leading contract research organisation, is  
expected 1H 2023. If positive, the results may provide opportunities for early-stage collaborations with  
partners developing nucleic acid drug candidates.  
PCI Biotech is exploring intratumoural immunotherapy with the fimaVACC program, aiming at  
identifying novel treatment combinations that may overcome resistance to immune-checkpoint  
inhibitors and safety-issues associated with such treatments. A patent application for an undisclosed  
treatment approach is planned to be filed in 2023. This project is supported by a Ph.D. candidate  
grant, commencing January 2023.  
PCI Biotech continues to pursue new and value-adding collaborative opportunities. Certain research  
collaborations were ended during 2022, based on review of progress and value, and new  
collaborations were initiated. The collaboration with the Norwegian Institute of Marine Research,  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
aiming to explore the use of photochemical treatments to combat salmon lice in fish farming, has  
demonstrated killing of free-swimming sea lice. Refinement of the principle is ongoing to evaluate if  
sea lice attached to fish can be combated, and a patent application is planned to be filed in 2023. This  
is an opportunistic, early-stage project, where domain expertise is ensured by collaboration with  
experts in the field, and further partnership is particularly important for progress.  
BUSINESS, LOCATION AND HUMAN RESOURCES  
PCI Biotech Holding ASA is a biopharmaceutical company headquartered in Norway and listed on the
Oslo Børs, with the ticker PCIB. The company is developing therapeutic products based on its  
proprietary photochemical internalisation (PCI) technology.  
The PCI Biotech group comprises PCI Biotech Holding ASA, and the wholly owned Norwegian  
subsidiary PCI Biotech AS. PCI Biotech is located at Ullernchausséen 64, Oslo, Norway.  
The Board of Directors – The Board of Directors consist of Hans Peter Bøhn (Chairman), Hilde  
Furberg, Christina Herder, Lars Viksmoen and Andrew Hughes, who were all elected for a one-year  
term at the annual general meeting in May 2022.  
Employees - All operations of the Group are managed by PCI Biotech AS and the Group had 7  
employees as of 31 December 2022 (2021: 17 employees). The parent company has no employees.  
The Group mainly uses external service providers for manufacturing, research and development, and  
regulatory work.  
The management team consists of Ronny Skuggedal, Chief Executive Officer and Chief Financial  
Officer, Anders Høgset, Chief Scientific Officer, and Kristin Eivindvik, Chief Development Officer.  
The working environment is considered good. No accidents or injuries were reported in 2022 or 2021.  
Absence due to illness was 53 days, approximately 2.0% in 2022 (2021: 128 days, approximately  
4.7%).  
PCI Biotech aims to be a workplace with gender equality and where discrimination is not accepted. As  
of date of this report the Group has 40% female representation in the board of directors and 33% in  
the executive management team. 3 out of 7 employees as of year-end 2022 were women (2021: 9 out  
of 17). Working time and remuneration of the Group employees are not related to gender.  
OPERATIONS  
Operational overview  
fimaNAC  
Dermatology  
PCI Biotech aims to develop a topical formulation for delivery of nucleic acid therapeutics to skin using  
fimaNAC, to combine the ease of topical administration with enhanced delivery from fimaNAC.  
Current development aims to demonstrate fimaNAC-mediated nucleic acid delivery in an ex vivo  
wound model with topical administration to act as a stepping-stone towards partnership with nucleic  
acid therapeutics owners. This study, performed by a leading contract research organisation, has  
expected readout in 1H 2023.  
Bioprocessing  
Bioprocessing is the manufacturing of biologic drugs ("biologics"). There is a great need for  
technologies that enable more effective bioprocessing with higher yield as well as increased quality at  
a lower cost. PCI Biotech has identified the potential of its technology for use in several areas of  
bioprocessing. The first patent application was filed in 2022 and 2023 will be focussed on in-house  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
feasibility studies of fimaNAC for use in viral vector manufacturing and thereafter on getting feedback  
from potential customers by performing alpha testing.  
fimaVACC  
Refocussing the strategy  
The company announced in August 2022 that the previously reported efforts to finance a Ph II clinical  
trial in head and neck cancer did not, under the current market conditions, result in a feasible way  
forward and PCI Biotech will not conduct a company-sponsored Ph II trial with the fimaVACC  
technology. The company now focusses its efforts and resources on non-clinical research exploring  
new fields of use for the PCI technology utilising fimaVACC for intratumoural immunotherapy, with a  
partnership-driven development strategy.  
A Ph.D. industry candidate grant of up to NOK 2.5 million over 3 years is granted by the Research  
Council of Norway, dedicated to the development of intratumoural immunotherapy, commencing 1st  
January 2023.  
Publication of preclinical BCG vaccination results  
In January 2022, positive results from preclinical studies on BCG vaccination performed in  
collaboration with The University of Zurich and ETH Zurich were accepted for publication in Frontiers  
in Immunology, a high impact immunology journal. The article title is "Photochemically-mediated  
inflammation and cross-presentation of Mycobacterium bovis BCG proteins stimulates strong CD4 and  
CD8 T-cell responses in mice”. Infectious diseases are not within PCI Biotech’s core focus areas, but  
the results support our general understanding of fimaVACC’s mode of action and the potential of the  
technology.  
Research collaborations  
PCI Biotech has an active collaborative strategy for fimaNAC and fimaVACC. The collaboration  
partners include MDimune, OliX Pharmaceuticals, IMV, and Mymetics. In these collaborations, PCI  
Biotech and the partners are exploring synergies between their proprietary technologies, with potential  
expansion of the partnerships. PCI Biotech continues to pursue new and value-adding collaborative  
opportunities for the fimaNAC and fimaVACC programmes.  
In January 2022, PCI Biotech entered a new fimaNAC research collaboration with MDimune, a South  
Korean biotech company developing a versatile drug delivery system based on nanosized vesicles  
obtained from cells. In August 2022 a fimaVACC research collaboration was initiated with Mymetics, a  
company based in Switzerland and a pioneer in the research and development of virosome-based  
vaccines and immunotherapies against infectious and life-disabling diseases. This aims to explore  
technological synergies for cancer therapy.  
All collaborations have during 2022 been reviewed for progress, value, and priorities set by both  
parties. Three previous collaborations (eTheRNA, Aposense and Mendus) have been closed as a  
result of such evaluations.  
Collaboration with Norwegian Institute for Marine Research (NIMR)  
NIMR (Havforskningsinstituttet) received in 2021 a NOK 4.5 million grant from the Norwegian Seafood  
Fund for a 2-year collaboration project with PCI Biotech ending June 2023. The project aims to explore  
the use of photochemical treatments to combat salmon lice in fish farming. NIMR will perform the  
research, and PCI Biotech will provide expertise and compounds and retain commercial rights to the  
results of the project. Several photosensitizing compounds are tested in the project and refinement of  
the principle is needed. This will continue in 2023.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
Corporate  
Termination of the RELEASE trial and closure of the fimaCHEM program  
The RELEASE trial was terminated in Q1 2022, due to changes in the competitive landscape that  
rendered the trial challenging to complete and potentially inadequate for approval. PCI Biotech  
focused on a swift and cost-efficient closing process of the trial. Sites with no ongoing patients (nearly  
60%) were closed immediately. The last patient discontinued the study in May and all remaining  
clinical sites were closed by the end of June 2022. Other major study closure activities were  
completed during 2022, including publishing the study results in the EU clinical trial database, while  
publication on clinicaltrials.gov is pending as of date of this report. The trial enrolled a total of 41  
patients, of which 34 patients provided efficacy data. Data collected in the study was insufficient to  
draw conclusions regarding the efficacy of the PCI treatment.  
The RELEASE trial has been a tremendous effort and the company would like to thank all external  
contributors, not least the enrolled patients and the clinical sites for their willingness to contribute to  
the benefit of future patients and their relatives.  
The swift wind-down of RELEASE allowed the company to reallocate resources to the other  
development programmes. The remaining cash effect for the closure process of RELEASE, from 1st  
January 2023, is estimated to be less than NOK -1 million.  
Organisational changes  
Following the termination of the RELEASE trial and closure of the fimaCHEM program the clinical team  
was reduced during the first half of 2022. The decision in August 2022 not to pursue a PCI Biotech-  
sponsored fimaVACC Ph II study entailed full disbandment of the clinical team, which was enacted  
during the second half of 2022 with a full cost reduction effect in Q1 2023.  
Per Walday (former CEO), resigned in March to assume a new position and it was mutually agreed  
that he stepped down from his position at the end of May. Ludovic Robin (former CBO), left the  
company in May 2022. Amir Snapir (former CMO), left the company in September 2022. Ronny  
Skuggedal (CFO), was appointed Interim CEO effective 1st June, and promoted to CEO effective 1st  
September 2022, currently holding both positions.  
Scientific Advisory Committee  
The Scientific Advisory Committee (SAC) composition has changed due to PCI Biotech’s  
reprioritisation of programs during 2022 and now consist of: Inventor of the photochemical  
internalisation technology, Prof. Kristian Berg (Head of Department of Radiation Biology, Institute for  
Cancer Research, Oslo University Hospital) and Prof. Ernst Wagner (Ludwig-Maximilians-Universität  
and the Center of Nanoscience in Munich), with distinguished expertise and experience in the field of  
targeted delivery of nucleic acids and protein therapeutics. The SAC will be supplemented with  
additional expertise when considered appropriate.  
Conferences  
The company participated on-site at the following conferences during 2022: LSX World Congress  
(London, UK), NLS Days (Malmø, Sweden), BIO-Europe (Leipzig, Germany), and European Society  
for Gene and Cell Therapy Collaborative Congress (Edinburgh, UK). The company also participated at  
the BIO-Europe Spring digital event. In addition, an overview of PCI Biotech’s proprietary platform  
technology for use in the exciting field of mRNA-based therapies was presented at the TIDES USA  
2022 conference.  
Business development  
PCI Biotech's strategy is to create value by efficient development of the business areas towards  
commercialisation. The commercialisation of products is intended primarily through agreements with  
external partners based on preclinical data.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
FINANCIAL REVIEW  
(All amounts in brackets are comparative figures for 2021 unless otherwise specifically stated)  
Profit and loss  
The Group did not record revenues in 2022 or 2021. Grants received from various public sources such  
as the Research Council of Norway and ”SkatteFUNN” were recorded as other operating income  
amounting to NOK 4.8 million (NOK 6.3 million). The parent company did not record any revenue for  
2022 or 2021.  
Expenditure on research activities is recognised as an expense in the period in which it was incurred.  
The Group had no development expenditure qualifying for recognition as an asset under IAS 38 in  
2022 and as for previous years all research expenses are charged through the profit and loss  
statement. Total operating expenses were NOK 61.2 million in 2022 (NOK 92.3 million) and expenses  
are mainly driven by the research and development (R&D) activities. R&D expenses amounted to  
NOK 44.8 million in 2022 (NOK 71.7 million). Other operating (general and administrative) expenses  
were NOK 16.4 million (NOK 20.6 million). The change in general and administration costs is mainly  
driven by non-cash accounting elements for the share option scheme for employees, and reduced  
number of employees. Operating result in 2022 ended at NOK -56.4 million (NOK -86.0 million) for the  
Group. Operating result for the parent company were NOK -5.2 million in 2022 (NOK -5.0 million).  
Net financial result for the Group was NOK 1.4 million positive in 2022 (NOK 2.4 million negative). The  
net positive result in 2022 was mainly driven by interest income, while 2021 was impacted by a  
negative effect of NOK 2.5 million from cash deposits placed in EUR at year-end, as a hedge of the  
foreign currency risk for the RELEASE study. The parent company’s financial income for 2022  
consists mainly of interest on loans to the subsidiary PCI Biotech AS. In 2021 and 2022 the parent  
company made a partial write-down of its investment in the wholly-owned subsidiary PCI Biotech AS,  
based on the observable fair value of the Group at Oslo Børs per year-end. The NOK 463.7 million  
(NOK 148.8 million) write-down is disclosed as financial expenses for the parent company.  
The Board of Directors proposes that the comprehensive loss of NOK 467.2 million in 2022 for the  
parent company, PCI Biotech Holding ASA, is covered by retained earnings, other paid-in capital and  
share premium.  
Balance sheet  
Property, plant and equipment at the beginning of 2022 mainly consisted of devices used in the  
RELEASE trial. In January 2022 the company decided to stop the RELEASE trial, and the post-  
decision value of devices dedicated to this trial are considered low. These devices were recognised  
with a carrying value of NOK 5.8 million in the balance sheet, and depreciated in full in January 2022  
without cash-flow effect. Right to use assets is partly reduced during 2022 due to a reduction of the  
office lease space, with corresponding effect on lease liabilities.  
Short term receivables per end of 2022 were NOK 6.1 million (NOK 12.2 million) and mainly consist of  
recognised not received public grants. The reduction compared to last year is mainly due to off-setting  
advance payments in connection with the RELEASE trial during 2022.  
Current liabilities were generally lower per the end of 2022 compared to the end of 2021, mainly due  
to decreased scope of operations during 2022.  
Total equity for the Group were NOK 57.4 million per year-end 2022 (NOK 113.8 million). Total equity  
of the parent company amounts to NOK 76.0 million in 2022 (NOK 544.6 million) reflecting this year’s  
result and equity settled share-based payment elements for the Group’s share option scheme.  
Equity in the wholly-owned subsidiary PCI Biotech AS was NOK 50.5 million at the end of 2022 (NOK  
73.4 million). The equity in PCI Biotech AS were increased in 2022 by NOK 30 million, through a  
capital increase from the parent company PCI Biotech Holding ASA.  
Total assets of the Group at the end of 2022 were NOK 63.5 million (NOK 136.0 million) and the  
decrease from last year is mainly due to net loss from operational activities. Total assets in the parent  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
company amounted to NOK 77.2 million per year-end 2022 compared to NOK 545.7 million at year-  
end 2022, mainly reflecting the write down of shares in the subsidiary.  
PCI Biotech does not recognise deferred tax assets in the balance sheet, due to uncertainty as to  
when the company will accrue a payable tax liability. Unrecognised deferred tax assets at the end of  
2022 were NOK 156.4 million (NOK 142.9 million).  
Cash flow  
Net cash flow from operating activities amounted to NOK -59.0 million in 2022 (NOK -68.3 million) for  
the Group and for the parent company to NOK -3.5 million for 2022 (NOK -3.5 million). Net change in  
cash and cash equivalents for the Group was NOK -59.5 million in 2022 (NOK -71.9 million). Net  
change in cash and cash equivalents for the parent company were NOK -25.8 million in 2022 (NOK -  
42.0 million).  
The Group held cash and cash equivalents of NOK 56.6 million at the end of 2022, compared to NOK  
116.1 million per end of 2021, reflecting net negative changes in cash of NOK 59.7 million in 2022  
(NOK 69.3 million) and NOK 0.2 million net positive (NOK 2.5 million net negative) exchange rate  
effect on bank deposits in foreign currency. Cash flow from operations is mainly dependent on R&D  
activities. The Group employs a prudent cash management strategy for its cash and cash equivalents  
and assets are held as bank deposits or invested in low-risk short-term money market instruments. All  
cash and cash equivalents were held as bank deposits at the end of the year.  
The Parent’s cash and cash equivalents at the end of 2022 amounted to NOK 0.6 million (NOK 26.5  
million).  
Employee share option scheme  
In accordance with the authorisation granted by the Annual General Meeting 25 May 2022, the Board  
of Directors of PCI Biotech Holding ASA awarded a total of 570,000 share options to key employees in  
November 2022. Each share option gives the right to subscribe for or acquire one share per option  
(after PCI Biotech Holding ASA’s choice), at a strike price of NOK 1.90, equal to the volume weighted  
average share price (VWAP) for the last 5 days of trade prior to the grant date.  
The share options are granted without consideration and are subject to service based vesting  
conditions, with a three-year vesting term and one-third vest each year. The share options are lapsing  
in Q3 2027. Further details about the share option scheme are described in PCI Biotech's  
remuneration policy.  
Related parties transactions  
All material transactions between the Group and shareholders, directors, management or close  
associates of such parties are to be valuated independently by a third party. No such transactions  
exist for 2022.  
In 2022 the Group had regular business transactions with Helpyou2 Ltd. a UK based company owned  
by Prof. Andrew Hughes, a Director in PCI Biotech Holding ASA. The services rendered concern Prof.  
Hughes position as member of the Scientific Advisory Committee (‘SAC’), and related agreed scientific  
consultancies by Prof. Hughes during the year. The services rendered are pre-approved by the Board  
of Directors and regular fee overviews are presented for the Board of Directors. Helpyou2 Ltd. has not  
received any fees for services related to the SAC for 2022 or 2021. For other agreed scientific  
consultancies, Helpyou2 Ltd. received NOK 15 thousand in fees for 2022 (2021: NOK 24 thousand). It  
is in management and the Board of Director’s opinion that the service fee is based on ‘arm’s length’  
principles and the level of consultancy is not considered to constitute a threat to independence for the  
parties in 2022 or 2021. Please refer to Note 23 Related party transactions to the financial statements  
for 2022 where information regarding related party transactions are disclosed.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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RISK AND RISK MANAGEMENT  
Implications of the COVID-19 pandemic and the war in Ukraine  
PCI Biotech decided to terminate the RELEASE study in January 2022, and operational implications of  
the COVID-19 pandemic have been minimal since. The war in Ukraine started after the company  
decided to terminate the RELEASE trial and have therefore no material impact on the operations for  
PCI Biotech. No accounting implications of the Russian invasion of Ukraine or the COVID-19  
pandemic that require specific IFRS disclosure are identified.  
Corporate governance policy, corporate social responsibility and transparency  
The annual statement of corporate governance policy, corporate social responsibility and the  
Transparency Act are integrated parts of this Board of Directors report.  
Operational Risk and Risk Management  
There are great risks in the business of developing medical drugs, new technologies, and innovative  
products, both related to regulatory affairs and market risk. The development may fail at any stage of  
the process, due to safety considerations, lack of clinical results, changes in clinical development or  
patient management, any other matters affecting patient’s ability or willingness to participate in clinical  
trials, and partners willingness to test prototypes and innovative products may impede development. It  
is not possible to predict with certainty whether and when PCI Biotech or its partners will be able to  
submit applications to regulatory authorities in the relevant markets. Moreover, one cannot be sure  
that PCI Biotech or partners will receive the marketing authorisations to commercialise the products.  
Regulatory approval and specific regulatory designations may be denied, suspended or limited. Poor  
performance of PCI Biotech’s potential products and technologies on the market and new  
technologies and innovative or generic products that are not yet launched may also limit the  
competitive edge of PCI Biotech’s products and impact pricing and/or reimbursement. PCI Biotech’s  
business strategy is to commercialise its technology partly through collaborative agreements and the  
Company cannot give any assurance that such agreements will be obtained on acceptable terms.  
There is no certainty that PCI Biotech or its partners will achieve commercial success. The success,  
competitive position, and future revenues will depend in part on PCI Biotech’s ability to protect  
intellectual property and know-how. Patent applications filed by others could also limit PCI Biotech’s  
freedom to operate. Changes in the healthcare market and/or the market access environment could  
further preclude PCI Biotech from charging a premium price or obtaining coverage and/or  
reimbursement for the Company’s products. The Company is highly dependent upon having a highly  
qualified senior management and scientific team. The loss of key employees might impede the  
achievement of the scientific development and commercialisation objectives. PCI Biotech cannot be  
certain that it will be able to enter into satisfactory agreements with third-party suppliers or  
manufacturers.  
To handle the inherent risks in the industry, and to comply with national and international regulations,  
PCI Biotech has implemented a process to identify, analyse and manage the key risks for the Group,  
including the character of the relevant insurance policies.  
The directors and officers of PCI Biotech Holding ASA and its subsidiary PCI Biotech AS are covered  
under a world-wide Group Director & Officer’s Liability Insurance. The insurance covers personal legal  
liabilities including defence and legal costs. The cover also includes employees in managerial  
positions who become named in a claim or investigation. The Group does not pollute the external  
environment.  
Financial Risk and Risk Management  
The Group’s activities are exposed to certain financial risks including currency risk, interest rate risk  
and liquidity risk. The risk is of such character that the Group has chosen to put in place measures to  
mitigate the potential currency risk of the financial markets and a prudent strategy regarding interest  
rate risk.  
Regarding liquidity risk, PCI Biotech's most important future sources of financing are revenue related  
to any licensing and collaboration agreements, government grants and equity issues. The biotech  
industry is a resource demanding industry, and drug development can be both labour and cash  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
intensive. PCI Biotech being a pre-commercial stage biotech, means that the Company mainly relies  
on the ability to raise funds via the equity market and government grants for its development plans,  
and no assurance of the availability of resources for current and future development plans can be  
made, especially not under the current equity market conditions for the biotech industry. The equity  
capital market is used as a source of liquidity when appropriate and conditions within this market are  
competitive.  
Currency risk - The Group's expenses and revenues are incurred in multiple currencies. The Group is  
therefore exposed to fluctuations in exchange rates. The risks are assessed on a regular basis. PCI  
Biotech is currently not using any financial hedging instruments.  
Interest rate risk - PCI Biotech has no interest-bearing debt and interest risks are mainly related to the  
Group's holdings of cash and cash equivalents. The Group employs a prudent cash management  
strategy for its cash and cash equivalents, and assets are placed as bank deposits or invested in low-  
risk short-term money market instruments. Per year-end 2022 all cash and cash-equivalents are  
placed as bank deposits.  
Liquidity Risk - One of the main objectives of PCI Biotech's financial policy is to ensure that the Group  
has sufficient short- and long-term financial flexibility to achieve strategic and operational objectives.  
PCI Biotech's goal is to at least have sufficient cash to cover the expected capital need for the next 12  
months, as well as a strategic reserve. The Group closely monitors cash flows based on short- and  
long-term forecasts. Cash burn rate depends mainly on the level of activity in the development  
programmes. The programmes do not involve substantial long-term commitments for the Group,  
allowing flexibility for adjusting operational activities. The current cost base for the Company is  
reduced over time in 2022, mainly due to the closure of the RELEASE trial and implemented cost  
reductions during the year, slimming down both the operational- and executive team. PCI Biotech has  
no external debt with financial covenants or any long-term debt. The cash position per year-end 2022  
is on this basis estimated to enable a financial runway towards the end of 2024.  
GOING CONCERN  
In accordance with § 3-3a of the Norwegian Accounting Act (NAA) it is confirmed that the conditions  
for assuming that the Group will continue as a going concern are present and that the financial  
statements have been prepared on the basis of this assumption. The Board of Directors refers to the  
document on corporate governance in the annual report relating to corporate governance (NAA § 3-  
3b) and corporate social responsibility (NAA § 3-3c).  
SUBSEQUENT EVENTS  
PCI Biotech is not aware of any other subsequent events since year-end 2022 which are of material  
significance to the financial statements as of 31 December 2022.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
12  
 
Enabling intracellular delivery  
OUTLOOK  
PCI Biotech’s proprietary PCI technology enables intracellular delivery, which provides the possibility  
to unlock the true potential of certain classes of innovative medicines, and develop new technologies  
and innovative products. The PCI technology has the opportunity to play a significant role in the  
realisation of several new therapeutic modalities, including nucleic acid therapeutics (fimaNAC) and  
immunotherapy (fimaVACC).  
The fimaNAC programme follows a collaborative approach, by development of applications in the  
most attractive areas for the technology and pursuing out-licensing opportunities. The fimaVACC  
programme aims to enhance immunotherapy in cancer, by triggered endosomal release of antigens or  
nucleic acids encoding antigens, or immunostimulatory factors.  
The main priorities of PCI Biotech are to:  
•
•
Focus efforts and resources on pre-clinical research for technology platform development  
Manage alliance and partnering activities across all commercially interesting areas for the PCI  
platform  
Oslo, 27 April 2023  
Board of Directors and Chief Executive Officer,  
PCI Biotech Holding ASA  
Hans Peter Bøhn  
Hilde Furberg  
Chairman  
Director  
Christina Herder  
Andrew Hughes  
Director  
Director  
Lars Viksmoen  
Ronny Skuggedal  
Director  
CEO  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
13  
 
Enabling intracellular delivery  
RESPONSIBILITY STATEMENT FROM THE BOARD OF DIRECTORS AND CEO  
We confirm that the financial statements for the period 1 January to 31 December 2022, to the best of  
our knowledge, have been prepared in accordance with IFRS and that the accounts give a true and  
fair view of the assets, liabilities, financial position and results of operations, and that the information in  
the report includes a fair review of the development, performance and position of the Company and  
the Group, together with a description of the principal risks and uncertainties PCI Biotech faces.  
Oslo, 27 April 2023  
Board of Directors and Chief Executive Officer,  
PCI Biotech Holding ASA  
Hans Peter Bøhn  
Hilde Furberg  
Chairman  
Director  
Christina Herder  
Andrew Hughes  
Director  
Director  
Lars Viksmoen  
Ronny Skuggedal  
Director  
CEO  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
ANNUAL STATEMENT ON CORPORATE GOVERNANCE POLICY AND  
CORPORATE SOCIAL RESPONSIBILITY POLICY AND  
THE TRANSPARENCY ACT  
PCI Biotech Holding ASA emphasises good corporate governance
The Norwegian Code of Practice for corporate governance is a guideline for listed companies to help  
regulate the division of roles between shareholders, the board of directors and executive management  
more comprehensively than is required by legislation.  
PCI Biotech Holding ASA (“PCI Biotech” or “The Company”) bases its policy for corporate governance  
on the Norwegian Code of Practice of 14 October 2021. Adherence to the code of practice is  
implemented on the basis of a "comply or explain principle".  
The Board of Directors and management have resolved as a main principle to follow the  
recommendations of the Norwegian Corporate Governance Code (“the Code”) to the extent not  
considered unreasonable due to the company size and stage of development. Explanations of non-  
conformance to the Code are provided if not fully implemented. PCI Biotech’s compliance with the  
Code is described in this report and section numbers refer to the Code’s chapters.  
1. Implementation and reporting on corporate governance  
PCI Biotech acknowledges the division of roles between shareholders, the Board of Directors, and the  
executive management team. PCI Biotech has implemented a sound corporate governance policy.  
Guidelines on corporate governance and statement of compliance with the Code is presented in the  
Company’s annual report and website. The Company ensures that the policy is adopted by holding  
regular Board of Directors’ meetings where the executive management team attends to present  
strategic, operational, and financial matters.  
Corporate values are established with the purpose to establish a healthy corporate culture and  
preserve the Company's integrity by helping employees to comply with standards of good business  
conduct. Furthermore, the values are intended to be a tool for self-assessment and for further  
development of the Company's identity. Corporate values are important foundations for PCI Biotech's  
corporate governance. Ethical guidelines are also established and these guidelines are based on  
corporate values.  
PCI Biotech adheres to the code of practice for corporate governance. The company has to date six  
deviations from the code and the reasons for the deviations and solutions selected are further  
explained under section 2.1, 6, 9 and 12.  
2. Business  
The objective and purpose of PCI Biotech’s business are clearly defined and described in the articles  
of association. “The Company’s business activities shall include cancer treatment and drug delivery  
based on the PCI technology and other related activities, including participation in other companies  
with similar activities through equity, loan or by issue of guarantees.” The Company’s articles of  
association are available at the Company’s website and the Company’s objectives and strategy are  
available in the annual report.  
PCI Biotech has defined development programmes with clear objectives, strategies, and risk profiles  
for the company’s business activities to enable PCI Biotech to create long-term value for its  
shareholders. The Board of Directors performs annual evaluations of the objectives, strategies, and  
risk profiles.  
The company has implemented guidelines for how to integrate stakeholder considerations into its  
value creation in a sustainable manner, through corporate social responsibility and ethical guidelines.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
2.1 Corporate social responsibility (CSR)  
PCI Biotech is a Norwegian based company focusing on research and development within the field of  
cancer treatment. The PCI Biotech Group consists of 7 employees and the core competencies are  
possessed by these employees, while the group's other resources in research and development are  
mainly purchased from public and private research institutions and service providers across Europe  
and USA.  
As of today, the Group has no sales or supply of services and a limited complexity in operations. The  
Group has established guidelines and policies in accordance with internal control policies for  
comparable businesses of similar size, complexity, and industry to fight corruption. This means that  
the group requires its directors and employees to demonstrate high ethical standards in business and  
interpersonal relationships. Other principles followed are prevention through awareness-raising,  
limitation of opportunities, high detection risk of, and zero tolerance for corruption.  
The Group has established its own quality control system in line with authorities’ requirements within  
the activities that the Group operates, in terms of production and storage of pharmaceutical products,  
and in connection with clinical studies. The quality control procedures are based on the relevant  
activities in relation to the different phases of operation and the development of procedures is thus a  
dynamic process. The Group is concerned that staff have appropriate training and experience in their  
business areas and staff are regularly updated within their business fields.  
The Group is concerned with animal welfare, human- and labour rights, social issues and sustainable  
development. The Group's management conducts regular performance reviews and internal  
evaluations, and the Group adapts according to Norwegian law within the area. Preclinical and clinical  
research is subject to strict government regulation on animal welfare, human rights, and social  
conditions in all the countries where the research and development work is carried out, including  
South Korea and Taiwan where the RELEASE trial had open sites at selected hospitals in 2021 and  
parts of 2022. The Group therefore considers that animal welfare, human rights, labour rights, and  
social issues are well taken care of, both internally and among its subcontractors. Regarding  
sustainable development, please see section 2.2.  
The Group has not identified any material issues based on the corporate social responsibility  
procedures (CSR) performed in 2022. The implementation of further detailed specific objectives,  
strategies or action plans related to CSR, beyond the ones described above, has not yet been  
prioritised, but will be developed along with the continuous development of PCI Biotech’s operations.  
Non-conformance with the recommendation: The Group's operations are of such character that it does  
not significantly affect the environment and the Group therefore believes it is not appropriate to  
establish specific guidelines, policies, procedures and standards in this area, but environmental issues  
are included in PCI Biotech’s ethical guidelines and please also see the separate reporting regarding  
sustainable development in section 2.2.  
2.2 Sustainable development  
PCI Biotech is concerned with sustainability, but has not used any specific reporting standards or  
guidelines for sustainability reporting other than the Code and this section for sustainable development  
is considered an integrated part of the CSR reporting. In general PCI Biotech’s strategy and  
operations are focused on human welfare through its vision of ‘unlocking the potential of innovative  
medicines’. PCI Biotech focuses its development on anti-cancer product- and technology candidates.  
This vision and focus may directly contribute to one of the UN’s seventeen sustainable development  
goals, goal #3 ‘Good health and well-being’. All international anti-cancer development is strictly  
regulated regarding animal welfare and high focus on safety and well-being for patients participating in  
clinical trials. PCI Biotech have internal routines securing that the Group and service providers comply  
with all relevant standard in these regards.  
The Group's operations are of such character that they do not significantly affect the environment  
beyond normal course of business for a small biotech company, nevertheless the Company strives to  
minimise our environmental footprint in daily operations. Travelling and the need for shipment of  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
devices and materials for preclinical and clinical trials are identified as the activities with the most  
environmental impact. To keep the environmental impact to a minimum, devices that are no longer  
used are returned in bulk to the producer for recycling. Other shipments are optimised in collaboration  
with our service providers and collaborators to reduce the number of shipments. External meetings are  
evaluated for use of virtual meeting tools when appropriate, to limit travel to what is considered  
necessary from an operational and business development perspective.  
2.3 Ethical guidelines  
The ethical guidelines encompass the following elements: Core values, compliance with laws and  
regulations, working environment, interaction with different stakeholders, intragroup transactions,  
employees loyalty, conflicts of interest, confidentiality, environment, accounting, financial reporting,  
trading of Company shares, other employee activities and compliance with the ethical guidelines.  
2.4 Equality and diversity  
PCI Biotech's goal is to be a workplace with gender equality and where discrimination is not accepted.  
Respect for individuals is a cornerstone of our company values, accompanied by an including working  
environment. PCI Biotech strives to contribute to diversity and gender balance in recruitment  
processes, balanced with candidates’ expertise and capacity. During 2022, there was no recruitment.  
PCI Biotech’s total number of employees are 7, where of 3 are females and 4 are males. The  
management team consist of 3 employees, 1 female and 2 males. The Board composition comply with  
regulations for gender diversity with minimum 40% female representation for the current Board, with 2  
females and 3 males.  
2.5 Transparency Act  
PCI Biotech strives to comply with the new implemented act relating to enterprises’ transparency and  
work on fundamental human rights and decent working conditions (Transparency Act). The Act shall  
promote enterprises’ respect for fundamental human rights and decent working conditions and ensure  
the general public access to information regarding how enterprises address adverse impacts on  
fundamental human rights and decent working conditions. PCI Biotech includes the Transparency Act  
in its corporate social responsibility work, and this section regarding transparency is considered an  
integrated part of the CSR reporting. To comply with the Transparency Act a statement that is to be  
published before 30th June 2023 is included under section 16 of this annual statement.  
3. Equity and dividends  
PCI Biotech’s equity as of 31 December 2022 was NOK 57.4 million. The capital structure is regularly  
assessed in light of the Company’s objectives, strategy and risk profile. The equity level is assessed  
as satisfactory per year-end 2022. To tailor the share capital to current operations the Group will seek  
to make a write-down of the share capital level during 2023.  
To date the Company has not distributed any dividends and this dividend policy will apply as long as  
PCI Biotech is in a research and development phase. The Board of Directors has no mandate to  
approve the distribution of dividend.  
The Board of Directors has been authorised by the Company’s General Assembly in May 2022 to  
increase the share capital by share issue of up to 2,790,000 shares in connection with the Company’s  
employee incentive program and to issue shares in connection with private placements by an amount  
up to 10% of the share capital of the Company. The authorisations are valid to the next ordinary  
general assembly. Other than the above the Board of Directors has no general authorisation to issue  
shares.  
4. Equal treatment of shareholders  
PCI Biotech has only one class of shares and all shares have equal rights. Each share carries one  
vote.  
The Board of Directors and management are committed to treat all shareholders equally. The  
Company had no transactions in own shares during 2022.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
17  
 
Enabling intracellular delivery  
In the event of the Board of Directors resolving to issue new shares and waive the pre-emptive rights  
of existing shareholders, the Board of Directors intends to comply with the recommendation of the  
Norwegian Code of Practice for Corporate Governance that the justification for such waiver is noted in  
the Stock Exchange announcement relating to such a share issue.  
5. Shares and tradability  
The shares in PCI Biotech are freely tradable with no form of restriction. No restrictions regarding  
voting, ownership or tradability are placed on the shares in the Company’s articles of association.  
6. General Meetings  
The Board of Director’s facilitate that as many shareholders as possible may exercise their rights by  
participating at the General Meeting and that the General Meeting is an effective forum for both the  
views of shareholders and the Board of Director’s.  
The Chairman, the Chief Executive Officer (CEO) and the Chief Financial Officer (CFO) are present at  
the Annual General Meeting, along with representation from the Nomination Committee and the Group  
auditor.  
Shareholders who are unable to participate themselves may vote by proxy and a person can also be  
appointed to vote for the shareholders as a proxy. The Board of Directors may decide that  
shareholders may submit their votes in writing, including by use of electronic communication, in a  
period prior to the general meeting.  
Notice of the meeting and relevant documents, including the proposal of the nomination committee,  
are made available on the company website three weeks in advance of the meeting. Notice of the  
meeting is sent to all shareholders individually, or to their depository banks, three weeks in advance of  
the meeting. The meeting notice includes information regarding shareholders’ rights, guidelines for  
registering and voting at the meeting. The company provides information on the procedure for  
representation at the meeting through proxy, nominations of a person to vote on behalf of the  
shareholders and to the extent possible prepare a form which allows separate voting instructions for  
each matter, hereunder for individual candidates for appointment to the Group’s governing bodies.  
The deadline for notice of attendance is set as close to the meeting as practically possible and in  
accordance with the provisions in the Articles of Association.  
Non-conformance with the recommendation: PCI Biotech is a small company and has encouraged  
directors to attend the General Meeting. The entire Board has not usually attended the General  
Meeting as, thus far, the items on the agenda of the General Meeting have not required all directors to  
attend. The Chair of the Board is present, and other Board members participate on an ad hoc basis.  
From the Group’s perspective, this is considered sufficient. The recommendation to implement  
routines to ensure an independent chairing of the meeting has not been applied, both for cost and  
convenience reasons based on the size of the company. From the Group’s perspective, this is  
considered sufficient.  
7. Nomination Committee  
The requirement for a Nomination Committee and its guidelines follows from article 6 of the articles of  
association. The Nomination Committee's duties are to propose candidates for election to the Board of  
Directors and to propose remuneration. The Nomination Committee is required to justify its  
recommendations and encouraged to interact with shareholders, the Board of Directors and the Chief  
Executive Officer (CEO) in its work. The Nomination Committee’s members, including the chairperson,  
are elected by the General Meeting for two years at a time, unless otherwise resolved by the General  
Meeting and the General Meeting may adopt instructions for the Nomination Committee. The  
Nomination Committee shall consist of minimum two members who shall be shareholders or  
representatives for the shareholders. The remuneration to the members of the Nomination Committee  
is determined by the General Meeting.  
The Nomination Committee ensures that shareholders’ views are taken into account when qualified  
members are nominated to the governing bodies of PCI Biotech. Shareholders are encouraged to  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
submit proposals to the Nomination Committee for candidates for election to the board of directors.  
Such proposals must be in writing and justified and be submitted minimum 2 months before the  
General Meeting if they are to be considered by the nomination committee.  
None of the Committee’s members represents PCI Biotech’s management or Board and they are all  
considered to be independent of daily management and the Board. The Nomination Committee is  
considered to have a composition that reflects the common interests of the community of  
shareholders.  
The nomination committee currently consists of the following three members: Jónas Einarsson  
(chairperson), Erik Must and Trond Johansen. The current members have been elected by the general  
meeting with a term until the Company’s ordinary general meeting in 2023. The Nomination  
Committee’s contact details are available at PCI Biotech’s website.  
8. Board of Directors, composition and independence  
The Board of Directors is composed to ensure that the Board of Directors can operate independently,  
attend the common interest for all shareholders and the Company's need for expertise, capacity and  
diversity. The shareholders elect between three and seven members to the Board of Directors,  
including the Chair and they are elected for one-year terms by the General Meeting. The Board of  
Directors is presented on the company website. All board members are considered to be independent  
from the Company’s day-to-day management, main shareholders and material business connections.  
All board members are encouraged to be shareholders and their shareholdings are disclosed in the  
Annual Report.  
9. Work of the Board of Directors  
It is the responsibility of the Board of Directors to ensure that the Company has a well-functioning  
internal control environment in accordance with the regulations that apply to its activities and to  
supervise daily management and activities of the company in general. In addition, the Board of  
Directors is responsible for appointment of Chief Executive Officer (CEO) and convening and  
preparing for general meetings. The Board of Directors has implemented instructions for the Board  
and the executive management, with focus on allocation of internal responsibilities and duties. These  
instructions incudes handling of agreements with related parties, including whether an independent  
valuation must be obtained, and disclosure of such agreements in the annual directors’ report. The  
objectives, responsibilities and functions of the Board of Directors and the CEO are in compliance with  
rules and standards applicable for the Company.  
The Board of Directors should ensure that members of the Board and executive personnel make the  
Company aware of any material interests that they may have in items to be considered by the Board of  
Directors. The Board of Directors’ consideration of material matters in which the Chairman of the  
Board is, or has been, personally involved, shall be chaired by another member of the Board.  
The Board of Directors adopts an annual plan for its work, which includes objectives, strategy and  
implementation. The CEO is responsible for keeping the Board of Directors informed about the  
company’s activities, position and financial and operational developments. The Board of Directors  
evaluates its performance and expertise annually and the evaluation is made available to the  
Nomination Committee. The Company has not established a separate Audit Committee in accordance  
with the exemption in the Norwegian Public Limited Liability Companies Act. The Company has not  
established a separate Remuneration Committee. The Board of Directors in its entirety serves as both  
Audit and Remuneration Committee.  
The Board conducted twelve meetings in 2022. Board members had the following attendance at these  
meetings:  
Hans Peter Bøhn, 12/12  
Hilde Furberg, 12/12  
Christina Herder 11/12  
Lars Viksmoen,11/12  
Andrew Hughes 12/12  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Non-conformance with the recommendation: PCI Biotech has not established separate Audit and  
Remuneration Committees. The Board of Directors believes that this is most appropriate given the  
Company’s limited size and complexity. The Board of Directors will, depending on the Company's  
performance, consider appointing separate Audit and Remuneration Committees at a future date.  
10. Risk management and internal control  
It is the responsibility of the Board of Directors to ensure that the Company has sound internal controls  
and systems for risk management that are appropriate in relation to the extent and nature of the  
Company’s activities. Significant risks include strategic risks, market risks, financial risks, liquidity risks  
and operational risks including risks related to development of products. The internal control systems  
also include company values, code of ethics and corporate social responsibility. The Company’s  
significant risk areas and internal control systems are assessed on an on-going basis and at least  
once a year by the Board of Directors.  
Please also refer to The Board of Directors report, for a description of relevant risk factors.  
11. Remuneration of the Board of Directors  
The General Meeting determines the remuneration to the Board of Directors based on a proposal from  
the Nomination Committee. Remuneration reflects the Board of Directors responsibility, expertise, time  
commitment and the business complexity. The remuneration is not linked to the Company’s  
performance, and no share options are granted to Directors. Detailed information on the remuneration  
of the Board of Directors can be found in the Annual Report.  
Board members or companies to which they are connected should not undertake separate  
assignments for the Group in addition to the Board appointment. If they nevertheless do, the whole  
Board is to be informed. Fees for such assignments are to be approved by the Board. If remuneration  
has been paid above the normal Board fee, this is to be specified in the annual report.  
12. Remuneration of executive personnel  
The Board has established guidelines on the determination of salaries and other remuneration of  
executive management in accordance with § 6–16a of the Norwegian Public Companies Act. The  
remuneration guidelines shall be communicated to and approved by the Annual General Meeting. The  
remuneration guidelines seek to contribute to the alignment of interests between the shareholders and  
executive management and sets out the main principles in determining the salary and other  
remuneration for the executive management. Performance-related remuneration is linked to long-term  
value creation for shareholders and is based on quantifiable factors that can be influenced by the  
executive management. A share option scheme is part of the remuneration policy, and the scheme is  
approved by the general meeting.  
Non-conformance with the recommendation: The established guidelines for other performance-based  
remuneration of executive management do not set an absolute limit in terms of potential future value  
per awarded share option. As a corrective action share options awarded in 2022 were awarded with a  
value cap of 20 times the strike price. Great care is taken by the BoD when awarding share options to  
executive management and based on all elements of the guidelines for performance-based  
remuneration, and the value cap on share options awarded in 2022, the current guidelines are  
considered appropriate.  
13. Information and communication  
The Company presents its financial statements in accordance with IFRS, and procedures have been  
established to ensure compliance with IFRS interim and annual reporting requirements. The  
Company's management, the Chief Executive Officer (CEO) and Chief Financial Officer (CFO) are  
responsible for preparing the financial statements, and financial reports are approved by the Board of  
Directors prior to publication. PCI Biotech reports in accordance with the rules in the Norwegian  
Securities Trading Act, as well as with the requirements specified by the Oslo Børs for companies with  
listed shares.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
The Group’s report on corporate social responsibility is integrated into the annual report. The Board  
has set an IR policy for PCI Biotech’s reporting of financial and other information. The Board has  
approved guidelines and procedures relating to the handling of insider information and trading in the  
company’s shares.  
The Company's guidelines for reporting of financial and other information are based on transparency  
and take into account the requirement for equal treatment of all participants in the securities market.  
The Company is committed to report financial results and other relevant information on an accurate  
and timely basis. The Company publishes a financial calendar on an annual basis, including dates for  
release of interim and annual reports and dates for general meetings. PCI Biotech considers it  
important to inform shareholders about the Group’s development and economic and financial status.  
Management members are available for discussions with shareholders, other than through general  
meetings, to develop a balanced understanding of such shareholders’ situation and focus, subject  
however to the provisions in legislation and regulations. The Chair of the Board ensures that  
shareholders’ viewpoints are communicated to the entire Board.  
14. Take-overs  
The Board of Directors endorses the principles concerning equal treatment of all shareholders. In the  
event of a take-over bid, it is obliged to act in accordance with the requirements of Norwegian law and  
in accordance with the applicable principles for good corporate governance.  
The Board of Directors will not hinder or obstruct takeover bids for PCI Biotech’s activities or shares.  
The Board will ensure that shareholders are given sufficient information and time to form an opinion on  
an offer. If a takeover offer is received, the Board will issue a statement with a recommendation as to  
whether shareholders should or should not accept the offer.  
A transaction that in fact is a business disposal shall be approved by a General Meeting.  
15. Auditor  
Ernst & Young AS (EY) is the appointed auditor of PCI Biotech.  
The auditor shall annually in writing confirm to the Board of Directors that he/she satisfies established  
requirements for independence and objectivity. The auditor participates at least one Board of Directors  
meeting per year, where he/she present auditors plan for the audit, the assessment of the Company’s  
internal control and participate during the approval of the annual accounts. The auditor has a minimum  
of one meeting per year with the Board of Directors without the presence of the Executive  
Management. The Board of Directors has established separate guidelines for use of non-audit  
services. Fees paid to the external auditor for audit and non-audit services are reported in the  
Company’s Annual Report, which are, in turn, approved by the Annual General Meeting. The auditor is  
requested to participate at the Annual General Meeting for consideration of the annual financial  
statement.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
21  
 
Enabling intracellular delivery  
16. Statement of Transparency Act  
PCI Biotech strives to comply with the new implemented act relating to enterprises’ transparency and  
work on fundamental human rights and decent working conditions (Transparency Act). The Act applies  
to larger enterprises and applies to PCI Biotech being a listed company. The Act shall promote  
enterprises’ respect for fundamental human rights and decent working conditions in connection with  
the production of goods and the provision of services and ensure the general public access to  
information regarding how enterprises address adverse impacts on fundamental human rights and  
decent working conditions.  
The enterprises shall carry out due diligence in accordance with the OECD (Organisation for  
Economic Co-operation and Development) Guidelines for Multinational Enterprises. Due diligence  
means, among other things, identifying and assessing actual and potential adverse impacts on  
fundamental human rights and decent working conditions that the enterprise has either caused or  
contributed toward, or that are directly linked with the enterprise’s operations, products or services via  
the supply chain or business partners.  
Due diligence shall be carried out regularly and in proportion to the size of the enterprise, the nature of  
the enterprise, the context of its operations, and the severity and probability of adverse impacts on  
fundamental human rights and decent working conditions.  
Enterprises shall publish an account of due diligence and the account shall at least include:  
a) a general description of the enterprise's structure, area of operations, guidelines and procedures for  
handling actual and potential adverse impacts on fundamental human rights and decent working  
conditions  
b) information regarding actual adverse impacts and significant risks of adverse impacts that the  
enterprise has identified through its due diligence  
c) information regarding measures the enterprise has implemented or plans to implement to cease  
actual adverse impacts or mitigate significant risks of adverse impacts, and the results or expected  
results of these measures.  
Duty to account for due diligence:  
PCI Biotech confirms performance of due diligence in Q1 2023 in accordance with the above, and  
report the following:  
a) PCI Biotech is a biopharmaceutical company. The nature of operations is to perform research and  
development with the aim to develop novel therapies through its photochemical internalisation  
technology platform, within the two focus areas; fimaNAC and fimaVACC. The Group is domiciled in  
Norway, located at Oslo Cancer Cluster Innovation Park, and consist of the parent company PCI  
Biotech Holding ASA and the wholly owned subsidiary PCI Biotech AS. The Group is in pre-clinical  
and pre-commercial phase and has 7 employees per year-end 2022. The Group has no sales or  
supply of goods or services and a limited complexity in its operations.  
PCI Biotech’s business relationships can be categorised as service providers of standard professional  
services (legal, intellectual property, business development, contract research organisations etc.),  
academic institutions (pre-clinical research) or life-science related professionals (biotech’s, pharma,  
key opinion leaders etc.), and other suppliers of consumables. PCI Biotech’s main consumables are  
materials for in vitro and in vivo preclinical research commonly available across European and US  
based suppliers. The lead drug candidate, fimaporfin, is available on stock for internal purposes. The  
previous batch was produced in 2019 in Europe and there is no immediate need for production of a  
new batch.  
The Group is concerned with human- and labour rights, social issues and sustainable development.  
Fundamental human rights and decent working conditions for employees are handled by compliance  
to standard Norwegian employment regulations, annual (minimum) individual employee meetings,  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
22  
 
Enabling intracellular delivery  
established remuneration policy, regular workload reporting, regular management and employee  
assembly meetings, annual risk assessments, established EHS routines, onboarding and training  
routines, whistle-blowing routines, and ethical guidelines. For external affairs the company has  
implemented corporate social responsibility guidelines and core values follows by the ethical  
guidelines.  
b) The first due diligence was performed in Q1 2023. The assessment approach and methodology  
were based on the Transparency Act, section 4. Duty to carry out due diligence. To tailor the due  
diligence process to PCI Biotech’s size, nature and context of operations, and the severity and  
probability of adverse impacts on fundamental human rights and decent working conditions, a risk-  
based approach was applied. All suppliers were screened based upon product/service volume higher  
than NOK 0.1 million for the year of 2022 and expected future annual volumes, supplier category, and  
country of origin.  
This risk-based due diligence did not result in identification of suppliers or business partners with  
underlying significant risks of severe adverse impacts on fundamental human rights and decent  
working conditions caused or contributed toward by PCI Biotech, or increased risk for potential  
adverse impacts during 2023. Based on this risk-based due diligence no further procedures toward  
PCI Biotech’s supply chain and business partners were performed.  
For internal affairs compliance with fundamental human rights and decent working conditions were  
secured based on review of the above-described internal control routines. The review did not identify  
any actual adverse impacts or significant risks of adverse impacts on fundamental human rights and  
decent working conditions caused by PCI Biotech’s operations during 2022, or increased risk for  
potential adverse impacts during 2023.  
c) PCI Biotech is concerned with human- and labour rights, and social issues. Based upon PCI  
Biotech’s size, nature and context of operations, the potential severity and probability of adverse  
impacts on fundamental human rights and decent working conditions, and the outcome of the first due  
diligence performed in Q1 2023, it is not implemented specific guidelines, procedures or measures for  
handling of actual and potential adverse impacts on fundamental human rights and decent working  
conditions caused by, or directly linked via, our supply chain or business partners outside of the  
general corporate social responsibility guidelines and core values as stated in PCI Biotech’s ethical  
guidelines. PCI Biotech is prepared for implementation of such additional guidelines and procedures  
when deemed appropriate based upon the outcome of regular due diligence assessments or if there  
are changes to PCI Biotech’s size, and nature and context of operations that negatively impact the  
potential severity and probability of adverse impacts.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
23  
 
Enabling intracellular delivery  
PCI Biotech Holding ASA – financial statement  
STATEMENT OF COMPREHENSIVE INCOME  
For the year ended 31 December 2022  
(1.1 - 31.12)  
Parent  
2022  
Group  
2022  
2021 (figures in NOK 1,000)  
2021  
Note  
-
-
Other income  
4 750
6 273
5,6  
-
-
Total income  
4 750
6 273
-
5 222  
5 222  
-
Research and development  
44 756
71 707
16 441
20 595
61 197
92 302
7,8  
4 969 General and administrative  
4 969 Total operating expenses  
7,8,9,10,14,23,24  
-5 222  
-4 969 Operating results  
-56 447
-86 029
1 797  
1 593 Financial income  
1 711
359
789
3 151
11  
463 816 151 539 Financial expenses  
11,15, 24  
-462 020 -149 946 Net financial results  
1 352
-2 362
-467 242 -154 915 Profit/Loss before income tax  
-55 095
-88 391
-
-
Income tax  
-
-
12  
-467 242 -154 915 Net profit/loss for the year  
-55 095
-88 391
Other comprehensive income, net of tax  
-
-
-
-
Items that will not be reclassified to income statement  
Items that subsequently may be reclassified to income statement  
-
-
-
-
-467 242 -154 915 Total comprehensive income for the year  
-55 095
-88 391
Attributable to:  
Non-controlling interest  
Equity holders of the Parent  
-
-
-55 095
-88 391
Loss per share basic and diluted (figures in NOK)  
1.48
2.37
13  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
24  
 
Enabling intracellular delivery  
PCI Biotech Holding ASA  
BALANCE SHEET  
for the year ended 31 December 2022  
Parent  
2022  
Group  
2022  
ASSETS  
2021  
2021  
(figures in NOK 1,000)  
Note  
Non-current assets  
Property, plant and equipment  
Right to use assets  
Shares in subsidiary  
Total non-current assets  
-
-
-
-
18
705
-
5 806
1 854
-
14  
24  
15  
69 157  
69 157  
504 191  
504 191  
723
7 660
Current assets  
7 362  
23  
7 386  
15 019  
33  
15 052  
Receivables from group companies  
Other short-term receivables  
Total receivables  
-
6 162
6 162
-
12 200
12 200
18  
18  
17  
628  
26 476  
Cash and cash equivalents  
56 596
116 118
16,17,19  
8 013  
41 528  
Total current assets  
62 758
128 318
77 170  
545 719  
Total assets  
63 482
135 978
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
25  
 
Enabling intracellular delivery  
PCI Biotech Holding ASA  
BALANCE SHEET for the year ended 31 December 2022  
Parent  
Group  
2022  
EQUITY AND LIABILITIES  
2022  
2021  
2021  
(figures in NOK 1,000)  
Note  
Equity  
111 979  
111 979  
361 148  
31 626  
39 818  
Share capital  
111 979
111 979
450 464
0
20  
0
0
Share premium  
Other paid-in capital  
Retained earnings  
0
0
-35 944  
-54 577
-448 650
76 034  
544 570 Total equity  
57 403
113 792
8
Liabilities  
Non-current liabilities  
Other long-term liabilities  
-
-
16  
Long-term lease liabilities  
327
1 277
16, 24  
0
0
Total non-current liabilities  
327
1 277
Current liabilities  
6
-
140  
990  
19  
-
140  
990  
Trade account payables  
Current lease liabilities  
Public duties payables  
Other current liabilities  
495
443
1 225
3 590
3 745
629
1 713
14 823
24  
22  
1 136  
1 149  
Total current liabilities  
5 752
20 909
16,21  
1 136  
1 149 Total liabilities  
6 079
22 186
17  
77 170  
545 719 Total equity and liabilities  
63 482
135 978
Oslo, 27 April 2023  
Board of Directors and Chief Executive Officer,  
PCI Biotech Holding ASA  
Hans Peter Bøhn  
Christina Herder  
Hilde Furberg  
Chairman  
Director  
Director  
Andrew Hughes  
Lars Viksmoen  
Ronny Skuggedal  
Director  
Director  
CEO  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
26  
 
Enabling intracellular delivery  
PCI Biotech Holding ASA - GROUP  
CONSOLIDATED STATEMENT OF CHANGES IN EQUITY  
for the year ended 31 December 2022  
(attributable to the equity holders of the parent)  
Share  
capital  
Other paid-in  
capital  
Retained  
earnings  
Total  
equity  
(figures in NOK 1,000)  
Note  
Share premium  
20  
Equity 31 December 2020  
111 979
450 464
0
-373 199
189 244
Loss for the period  
-
-
-
-88 391 
-88 391
Other comprehensive  
income, net of tax  
-
-
-
-
0
Total comprehensive  
income for the period  
-
-
-
-
-
-
-
-
-
-
-
-
-
-88 391 
-88 391
Capital increase  
-
0
Capital increase expenses  
Share based payments  
Allocation  
-
-
0
12 939
0
12 939
-12 939
8
12 939
20  
Equity 31 December 2021  
111 979
450 464
0
-448 650 
113 792
Loss for the period  
Other comprehensive  
income, net of tax  
-
-
-
-55 095 
-55 095
-
-
-
-
0
Total comprehensive  
income for the period  
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-55 095 
-55 095
Capital increase  
-
-
0
Capital increase expenses  
Share based payments  
Allocation  
0
-1 294
0
-1 294
450 464
8
-450 464
20  
Equity 31 December 2022  
111 979
0
0
-54 577 
57 403
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
27  
 
Enabling intracellular delivery  
PCI Biotech Holding ASA - PARENT  
CONSOLIDATED STATEMENT OF CHANGES IN EQUITY  
for the year ended 31 December 2022  
Share  
capital  
Share  
premium  
Other paid-in  
capital  
Retained  
earnings  
(figures in NOK 1,000)  
Note  
Total equity  
20  
Equity 31 December 2020  
111 979 361 148  
18 687 194 732 686 546  
Profit for the period  
-
-
-
-154 915  
-154 915  
Other comprehensive  
income, net of tax  
-
-
-
-
0
Total comprehensive  
income for the period  
-
-
-
-
-
-
-
-
-
-154 915  
-154 915  
Capital increase  
-
-
0
0
Capital increase expenses  
Share based payments in  
subsidiary  
-
-
12 939  
-
12 939  
20  
Equity 31 December 2021  
111 979 361 148  
31 626  
39 818 544 570  
Profit for the period  
Other comprehensive  
income, net of tax  
-
-361 148  
-31 626  
-74 468  
-467 242  
-
-
-
-
0
Total comprehensive  
income for the period  
-
-
-
-361 148  
-31 626  
-74 468  
-467 242  
Capital increase  
-
-
-
-
-
-
0
0
Capital increase expenses  
Share based payments in  
subsidiary  
-
-
-
-1 294  
-1 294  
20  
Equity 31 December 2022  
111 979  
0
0
-35 944  
76 034  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
28  
 
Enabling intracellular delivery  
PCI Biotech Holding ASA  
CASH FLOW STATEMENT  
for the year ended 31 December 2022  
Parent  
2022  
Parent  
2021  
Group  
Group  
2021  
2022  
Note  
(figures in NOK 1,000)  
-467 242  
-154 915 Profit/Loss before income tax  
- Depreciation and amortization  
-55 095
6 406
78
-88 391
2 541
38
-
-
7,14  
24  
- Leasing interest cost  
463 740  
148 817 Write down investment in subsidiary  
- Share-based payments  
-
-
-
37  
10  
-13  
0
-1 294
-198
6 038
-3 250
-11 725
12 939
2 529
962
-1 445
2 520
8
2 513 Currency gain (-) / loss (+) not related to operations  
53 Changes in accounts receivables  
-41 Changes in account payables  
19  
86 Changes in other net operating assets and liabilities  
-3 468  
-3 487 Cash flow from operating activities  
-59 042
-68 307
-27 570  
5 227  
-41 598 Disbursement intragroup interest-bearing loan  
5 600 Proceeds intragroup interest-bearing loan  
- Investment in subsidiary  
-
-
-
-
-
-
-
-
-
15  
14  
- Acquisition of non-current assets  
-341
-22 343  
-35 998 Net cash flow from investing activities  
-
-341
-
-
-
- Payment principal portion of lease liability  
- Proceeds from issue of new equity  
- Expenses in relation to issues of new equity  
-678
-673
24  
8,20  
20  
-
-
-
-
0
0 Net cash flow from financing activities  
-678
-673
-25 811  
-39 485 Net changes in cash and cash equivalents  
-59 720
-69 321
-37  
26 476  
-2 513 Exchange rate effect bank deposits in foreign currency  
68 474 Cash and cash equivalents 1 January  
198
116 118
-2 529
187 967
19  
19  
628  
26 476 Cash and cash equivalents 31 December  
56 596
116 118
Additional information on operational cash flow  
187 Interest paid  
33  
49
198
639
1 796  
1 592 Interest received  
1 269
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
29  
 
Enabling intracellular delivery  
PCI BIOTECH HOLDING ASA – ACCOUNTING PRINCIPLES 2022  
1. Corporate information  
The annual accounts for 2022 for PCI Biotech Holding ASA (the Company) and the consolidated  
financial statement (the Group or PCI Biotech) was approved for publication by the Board of Directors  
on 27th April 2023.  
PCI Biotech Holding ASA is a public listed company domiciled in Norway. The business of the Group
is associated with research and development of pharmaceutical products and related technical  
equipment. The Company is listed on the Oslo Børs and the registered office address is  
Ullernchausséen 64, N-0379 Oslo.
2. Significant accounting policies  
2.1 Basis of preparation  
The Group and the Company’s annual accounts are prepared in accordance with International  
Financial Reporting Standards (IFRS) as specified by the International Accounting Standards Board  
and implemented by the EU as per 31 December 2022.  
The annual accounts for the Group and the Company have been prepared on the basis of historical  
cost. The financial income statement is presented by function of expense.  
NOK (Norwegian kroner) is the functional currency for all companies within the Group. In the absence  
of any statement to the contrary, all financial information is reported in whole thousands. As a result of  
rounding adjustments, the figures in the financial statements may not add up to the totals. The Group’s  
consolidated financial statements are presented in NOK, which is also the parent company’s functional  
currency.  
2.2 Basis of consolidation  
The consolidated financial statements comprise the financial statements of PCI Biotech Holding ASA  
and its wholly owned subsidiary PCI Biotech AS. The subsidiary is fully consolidated. The consolidated  
financial statements are prepared using uniform accounting policies for similar transactions and events  
under similar circumstances. Intercompany transactions and balances, including internal profits and  
unrealised gains and losses, are eliminated. All intra-group assets and liabilities, equity, income,  
expenses and cash flows relating to transactions between members of the Group are eliminated in full  
on consolidation.  
2.3 Summary of significant accounting policies  
a) Current
versus non-current classification  
The Group presents assets and liabilities in the statement of financial position based on current/non-  
current classification. An asset is current when it is:  
•
Expected to be realised or intended to be sold or consumed in the normal operating cycle  
•
Held primarily for the purpose of trading  
•
Expected to be realised within twelve months after the reporting period  
Or  
•
Cash or cash equivalent unless restricted from being exchanged or used to settle a liability for at  
least twelve months after the reporting period  
All other assets are classified as non-current.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
30  
 
Enabling intracellular delivery  
A liability is current when:  
•
It is expected to be settled in normal operating cycle  
•
It is held primarily for the purpose of trading  
•
It is due to be settled within twelve months after the reporting period  
Or  
•
There is no unconditional right to defer the settlement of the liability for at least twelve months  
after the reporting period  
The Group classifies all other liabilities as non-current. Deferred tax assets and liabilities are classified  
as non-current assets and liabilities.  
b) Government
grants  
Government grants are presented as other income, see Note 5 for further information. Government  
grants are recognised where there is reasonable assurance that the grant will be received, and all  
attached conditions will be complied with. When the grant relates to an expense item, it is recognised  
as income on a systematic basis over the periods that the related costs, for which it is intended to  
compensate, are expensed. When the grant relates to an asset, it is recognised as income in equal  
amounts over the expected useful life of the related asset.  
c) Taxes  
Current income tax  
Current income tax assets and liabilities are measured at the amount expected to be recovered from  
or paid to the taxation authorities. The tax rates and tax laws used to compute the amount are those  
that are enacted or substantively enacted, at the reporting date in the countries where the Group  
operates and generates taxable income.  
Current income tax relating to items recognised directly in equity is recognised in equity and not in the  
statement of profit or loss. Management periodically evaluates positions taken in the tax returns with  
respect to situations in which applicable tax regulations are subject to interpretation and establishes  
provisions where appropriate.  
Deferred tax  
Deferred tax is provided using the liability method on temporary differences between the tax bases of  
assets and liabilities and their carrying amounts for financial reporting purposes at the reporting date.  
Deferred tax liabilities are recognised for all taxable temporary differences.  
Deferred tax assets are recognised for all deductible temporary differences, the carry forward of  
unused tax credits and any unused tax losses. Deferred tax assets are recognised to the extent that it  
is probable that taxable profit will be available against which the deductible temporary differences, and  
the carry forward of unused tax credits and unused tax losses can be utilised.  
The carrying amount of deferred tax assets is reviewed at each reporting date and reduced to the  
extent that it is no longer probable that sufficient taxable profit will be available to allow all or part of  
the deferred tax asset to be utilised. Unrecognised deferred tax assets are re-assessed at each  
reporting date and are recognised to the extent that it has become probable that future taxable profits  
will allow the deferred tax asset to be recovered.  
Deferred tax assets and liabilities are measured at the tax rates that are expected to apply in the year  
when the asset is realised or the liability is settled, based on tax rates (and tax laws) that have been  
enacted or substantively enacted at the reporting date.  
Deferred tax relating to items recognised outside profit or loss is recognised outside profit or loss.  
Deferred tax items are recognised in correlation to the underlying transaction either in OCI or directly  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
31  
 
Enabling intracellular delivery  
in equity. Deferred tax assets and deferred tax liabilities are offset if a legally enforceable right exists  
to set off current tax assets against current tax liabilities and the deferred taxes relate to the same  
taxable entity and the same taxation authority.  
d) Foreign
currencies  
Transactions in foreign currencies are initially recorded by the Group’s entities at their respective  
functional currency spot rates at the date the transaction first qualifies for recognition. Monetary assets  
and liabilities denominated in foreign currencies are translated at the functional currency spot rates of  
exchange at the reporting date. Differences arising on settlement or translation of monetary items are  
recognised in profit or loss.  
e) Cash
dividend distribution to equity holders of the parent  
The Company recognises a liability to make cash distributions to equity holders of the parent when the  
distribution is authorised and the distribution is no longer at the discretion of the Company. As per the  
corporate laws in Norway, a distribution is authorised when it is approved by the shareholders. A  
corresponding amount is recognised directly in equity.  
f) Property,
plant and equipment  
Tangible fixed assets are recognised at cost less deductions for accumulated depreciation and write-  
downs (carrying amount). It is assessed at each reporting date whether there is an indication that an  
asset may be impaired. If any indication exists, the asset’s recoverable amount is estimated. An  
asset’s recoverable amount is the higher of an asset’s fair value, less costs of disposal, and its value  
in use. For assets where the carrying amount exceeds its recoverable amount, the asset is considered  
impaired and is written down to its recoverable amount. Tangible fixed assets are depreciated over the  
expected useful life of the assets taking any residual value into consideration. Costs accrued for major  
replacements and upgrades of tangible fixed assets are added to cost if it is probable that the costs  
will generate future economic benefits for the Group and if the costs can be reliably measured.  
Ordinary maintenance is expensed as incurred.  
Tangible fixed assets are depreciated on a straight-line basis over the estimated useful life of the asset  
as follows:  
- Production and test equipment 3-5 years  
- Furniture and equipment 3–5 years  
g) Leases  
The Group assesses at contract inception whether a contract is, or contains, a lease. That is, if the  
contract conveys the right to control the use of an identified asset for a period of time in exchange for  
consideration. The Group applies a single recognition and measurement approach for all leases,  
except for short-term leases and leases of low-value assets. The Group recognises lease liabilities to  
make lease payments and right-of-use assets representing the right to use the underlying assets.  
The Group recognises right-of-use assets at the commencement date of the lease (i.e., the date the  
underlying asset is available for use). Right-of-use assets are measured at cost, less any accumulated  
depreciation and impairment losses, and adjusted for any remeasurement of lease liabilities. The cost  
of right-of-use assets includes the amount of lease liabilities recognised, initial direct costs incurred,  
and lease payments made at or before the commencement date less any lease incentives received.  
Right-of-use assets are depreciated on a straight-line basis over the shorter of the lease term and the  
estimated useful lives of the assets. If ownership of the leased asset transfers to the Group at the end  
of the lease term or the cost reflects the exercise of a purchase option, depreciation is calculated using  
the estimated useful life of the asset. The right-of-use assets are also subject to impairment.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
32  
 
Enabling intracellular delivery  
At the commencement date of the lease, the Group recognises lease liabilities measured at the  
present value of lease payments to be made over the lease term. The lease payments include fixed  
payments (including in-substance fixed payments) less any lease incentives receivable, variable lease  
payments that depend on an index or a rate, and amounts expected to be paid under residual value  
guarantees. The lease payments also include the exercise price of a purchase option reasonably  
certain to be exercised by the Group and payments of penalties for terminating the lease, if the lease  
term reflects the Group exercising the option to terminate. Variable lease payments that do not depend  
on an index or a rate are recognised as expenses (unless they are incurred to produce inventories) in  
the period in which the event or condition that triggers the payment occurs.  
The lease liability is initially measured at the present value of the lease payments that are not paid at  
the commencement date, discounted using the interest rate implicit in the lease or, if that rate cannot  
be readily determined, PCI Biotech’ incremental borrowing rate. The incremental borrowing rate is  
used as the discount rate. After the commencement date, the amount of lease liabilities is increased to  
reflect the accretion of interest and reduced for the lease payments made. In addition, the carrying  
amount of lease liabilities is remeasured if there is a modification, a change in the lease term, a  
change in the lease payments (e.g., changes to future payments resulting from a change in an index  
or rate used to determine such lease payments) or a change in the assessment of an option to  
purchase the underlying asset.  
The Group applies the short-term lease recognition exemption to its short-term leases of machinery  
and equipment (i.e., those leases that have a lease term of 12 months or less from the  
commencement date and do not contain a purchase option). It also applies the lease of low-value  
assets recognition exemption to leases of office equipment that are considered to be of low value.  
Lease payments on short-term leases and leases of low-value assets are recognised as expense on a  
straight-line basis over the lease term.  
h) Intangible
assets - Research and development costs  
Research costs are expensed as incurred. Development costs will be capitalized once the asset being  
developed has met requirements of technical and commercial feasibility to signal that the intangible  
investment is likely to either be brought to market or sold.  
The Group has currently no development expenditure that qualifies for recognition as an asset under  
IAS 38. Following initial recognition of the development expenditure as an asset, the asset is carried at  
cost less any accumulated amortisation and accumulated impairment losses. Amortisation of the asset  
begins when development is complete, and the asset is available for use. It is amortised over the  
period of expected future benefit. Amortisation is recorded in cost of sales. During the period of  
development, the asset is tested for impairment annually.  
i) Impairment
of non-financial assets  
The Group assesses at each reporting date, whether there is an indication that an asset may be  
impaired. If any indication exists, or when annual impairment testing for an asset is required, the  
Group estimates the asset’s recoverable amount. An asset’s recoverable amount is the higher of an  
asset’s fair value less costs of disposal and its value in use. When the carrying amount of an asset  
exceeds its recoverable amount, the asset is considered impaired and is written down to its  
recoverable amount. Right-of-use assets are also subject to impairment.  
j) Financial
instruments  
Financial assets  
The Group´s financial assets are governmental grant receivables and cash and cash equivalents. The  
classification of financial assets at initial recognition depends on the financial asset’s contractual cash  
flow characteristics and the Group’s business model for managing them. The Group initially measures  
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a financial asset at its fair value plus, in the case of a financial asset not at fair value through profit or  
loss, transaction costs.  
The Group measures financial assets at amortised cost if both of the following conditions are  
met  
• The financial asset is held within a business model with the objective to hold financial assets in order  
to collect contractual cash flows and,  
• The contractual terms of the financial asset give rise on specified dates to cash flows that are solely  
payments of principal and interest on the principal amount outstanding.  
Financial assets at amortised cost are the most relevant category for the Group. Financial assets at  
amortised cost are subsequently measured using the effective interest (EIR) method and are subject  
to impairment. Gains and losses are recognised in profit or loss when the asset is derecognised,  
modified or impaired. A receivable represents the Group’s right to an amount of consideration that is  
unconditional.  
The Groups financial assets at amortised cost includes governmental grant receivables and cash and  
cash equivalents (short-term deposits). The Group does not have financial assets at fair value through  
profit and loss.  
Derecognition  
A financial asset (or, where applicable, a part of a financial asset or part of a group of similar financial  
assets) is primarily derecognised (i.e., removed from the Group’s consolidated statement of financial  
position) when:  
• The rights to receive cash flows from the asset have expired  
or  
• The Group has transferred its rights to receive cash flows from the asset or has assumed an  
obligation to pay the received cash flows in full without material delay to a third party under a ‘pass-  
through’ arrangement; and either (a) the Group has transferred substantially all the risks and rewards  
of the asset, or (b) the Group has neither transferred nor retained substantially all the risks and  
rewards of the asset, but has transferred control of the asset.  
Impairment of financial assets  
Further disclosures relating to impairment of financial assets are also provided in the following notes:  
• Note 16 Financial risk  
• Note 18 Receivables by year-end  
• Note 19 Cash and cash equivalents  
A financial asset is written off when there is no reasonable expectation of recovering the contractual  
cash flows.  
Financial liabilities  
Initial recognition and measurement  
Financial liabilities are classified, at initial recognition, as financial liabilities at fair value through profit  
or loss and other comprehensive income, loans and borrowings, or payables. All financial liabilities are  
recognized initially at fair value and, in the case of loans and borrowings and payables, net of directly  
attributable transaction costs. The Group’s financial liabilities include trade and other payables. The  
Group does not have financial liabilities at fair value through profit and loss.  
Subsequent measurement  
The measurement of financial liabilities depends on their classification. After initial recognition,  
payables are measured at their nominal amount when the effect of discounting when using the  
amortised cost measurement is not material. Amortized cost is calculated by taking into account any  
discount or premium on acquisition and fees or costs that are an integral part of the EIR. The EIR  
amortization is included as finance costs in the statement of profit or loss.  
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Derecognition  
A financial liability is derecognised when the obligation under the liability is discharged or cancelled or  
expires.  
k) Cash
and short-term deposits  
Cash equivalents are held for the purpose of meeting short-term cash commitments rather than for  
investment of other purposes. Cash and short-term deposits in the statement of financial position  
comprise cash at banks and short-term deposits with a maturity of three months or less, which are  
subject to an insignificant risk of changes in value.  
l) Provisions  
Provisions are recognised when the Group has a present obligation (legal or constructive) as a result  
of a past event, it is probable that an outflow of resources embodying economic benefits will be  
required to settle the obligation and a reliable estimate can be made of the amount of the obligation.  
m) Pensions
and other post-employment benefits  
PCI Biotech AS has an agreement with a life assurance company concerning contribution-based  
pensions for employees. Contributions, ranging from 7% to 21% of the employee’s ordinary salary up  
to 12 times the basic amount (G) of the Norwegian National Insurance scheme, are paid into the  
employee’s contribution account with the life assurance company. The Company’s payment of  
contributions is expensed in the period it is accrued. Any prepayments made to the contribution fund  
are recognised in the balance sheet.  
n) Share-based
payments  
Employees (including executive management) of the Group receive remuneration in the form of share-  
based payments, whereby employees render services as consideration for equity instruments (equity-  
settled transactions).  
Equity-settled transactions  
The cost of equity-settled transactions is determined by the fair value at the date when the grant is  
made using the Black-Scholes valuation model. That cost is recognised, together with a corresponding  
increase in other capital reserves in equity, over the period in which the service conditions are fulfilled  
in employee benefits expense. The cumulative expense recognised for equity-settled transactions at  
each reporting date until the vesting date reflects the extent to which the vesting period has expired  
and the Group’s best estimate of the number of equity instruments that will ultimately vest. The  
statement of profit or loss expense or credit for a period represents the movement in cumulative  
expense recognised as at the beginning and end of that period and is recognised in employee benefits  
expense. See Note 8 Salary expenses and other remuneration for further information.  
No expense is recognised for awards that do not ultimately vest, except for equity-settled transactions  
for which vesting are conditional upon a market or non-vesting condition. These are treated as vesting  
irrespective of whether or not the market or non-vesting condition is satisfied, provided that all other  
performance and/or service conditions are satisfied. When the terms of an equity-settled award are  
modified, the minimum expense recognised is the expense had the terms not been modified, if the  
original terms of the award are met. An additional expense is recognised for any modification that  
increases the total fair value of the share-based payment transaction, or is otherwise beneficial to the  
employee as measured at the date of modification. The dilutive effect of outstanding options is  
reflected as additional share dilution in the computation of diluted earnings per share, further details  
are given in Note 13 Earnings per share.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
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Enabling intracellular delivery  
o) License
costs  
Agreements with external parties concerning access to technology in the form of license agreements  
and agreements that allow the use of patented technology are expensed when they occur according to  
the agreement and are disclosed as “Research and development expenses” in the income statement.  
p) Segment
reporting  
Segments are reported similarly as the internal reporting to the Group’s Chief Operating Decision  
Maker. Chief Operating Decision Makers are defined as the Group’s management group. The Group  
has only one segment and see Note 6 for further information.  
q) Cash-flow
statement  
The statement of cash flows distinguishes between cash flows from operating, investing, and financing  
activities and the statement has been prepared in accordance with the indirect method. For the  
purpose of the consolidated statement of cash flows, cash and cash equivalents consist of cash at  
banks and short-term deposits with a maturity of three months or less. Cash and cash equivalents  
denominated in foreign currencies are translated at the functional currency spot rates of exchange at  
the reporting date. Differences arising from the translation of these monetary items are not considered  
to be related to operations and are presented as part of net changes in cash and cash equivalents.  
Interest paid and interest received are included under cash flow from operating activities. Cash flows  
from share issues are recognised as cash flows from financing activities.  
r) Events
after the balance sheet date  
New information regarding the Group’s financial position on the balance sheet date has been  
considered in the annual accounts. Events after the balance sheet date that do not affect the Group’s  
financial position on the balance sheet date, but which will affect the Group’s financial position in the  
future, are reported if they are significant.  
s) Contingent
liabilities and assets  
Contingent liabilities are defined as:  
•
Possible liabilities as a result of earlier events where their existence depends on future events;  
•
Liabilities that are not included because it is not probable that they will lead to an outflow of  
resources from the Group;  
•
Liabilities that cannot be measured with sufficient reliability.  
Contingent liabilities are not included in the annual accounts. Notes on significant contingent liabilities  
are provided, with the exception of contingent liabilities with little probability of occurring. Contingent  
assets are not included in the annual accounts, but are reported in cases in which there is a certain  
likelihood of their resulting in a benefit to the Group.  
Accounting policies only relevant for the Parent:  
t) Investment
in subsidiaries  
Shares and investments intended for long-term ownership are reported in the Company’s statement of  
financial position as non-current assets and valued at cost. The Company determines at each  
reporting date whether there is any objective indication that the investment in the subsidiary is  
impaired. If this is the case, the amount of impairment is calculated as the difference between the  
recoverable amount of the subsidiary and its carrying value and recognizes the amount in the  
statement of profit and loss. Any realised and unrealised losses and any write-downs relating to these  
investments will be included in the Company’s statement of comprehensive income as financial items.  
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991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
2.4 Changes in accounting policies and disclosures  
New and amended standards and interpretations  
The Group has not early adopted any new standards, interpretations or amendments that have been  
issued but are not yet effective in these financial statements. Other amendments and interpretations  
apply for the first time in 2022, but do not have an impact on the Group’s consolidated financial  
statements.  
3. Significant accounting estimates and assumptions  
The preparation of the Group’s consolidated financial statements requires management to make  
judgments, estimates and assumptions that affect the reported amounts of revenues, expenses,  
assets and liabilities, and the accompanying disclosures, and the disclosure of contingent liabilities.  
Uncertainty about these assumptions and estimates could result in outcomes that require a material  
adjustment to the carrying amount of assets or liabilities affected in future periods.  
Other disclosures relating to the Group’s exposure to risks and uncertainties include:  
•
Financial risk management and policies, Note 16 Financial risk.  
In the process of applying the Group’s accounting policies, management has made the following  
estimates and assumption, which have the most significant effect on the amounts recognised in the  
consolidated financial statements:  
•
The fair value of employee options is calculated according to the Black-Scholes method. This  
method involves the use of estimates and discretionary assessments, as described in more detail  
in Note 8. The allocation of options to employees of subsidiary is made directly from the parent  
company and the financial presentation is correspondingly reported in the subsidiary.  
•
The Group has not recognised a deferred tax asset related to carry forward losses, as described  
in more detail in Note 12 Tax.  
Significant accounting estimates and assumptions only relevant for the Parent  
In the process of applying the Group’s accounting policies, management has made the following  
judgments, which have the most significant effect on the amounts recognised in the separate financial  
statements for the Parent:  
•
PCI Biotech Holding ASA has in its separate financial statement performed an assessment of the  
carrying amount of the subsidiary PCI Biotech AS, see Note 11 Financial income and Note 15  
Shares in subsidiaries for further information.  
4. Standards issued, but not yet effective  
Certain new accounting standards and interpretations have been published that are not mandatory for  
31 December 2022 reporting periods and have not been early adopted by the Group. These standards  
are not expected to have a material impact on the entity in the current or future reporting periods and  
on foreseeable future transactions.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Enabling intracellular delivery  
PCI BIOTECH HOLDING ASA - NOTES FINANCIAL STATEMENT 2022  
5
OTHER INCOME  
OTHER INCOME  
(figures in NOK 1,000)  
Group  
2022  
2021  
SkatteFUNN  
4 750  
4 750  
Grants from the Research Council of Norway  
0
1 422  
Other  
0
101  
Total other income  
4 750  
6 273  
Government grants are recognised where there is reasonable assurance that the grant will be  
received, and all attached conditions will be complied with. When the grant relates to an expense item,  
it is recognised as income on a systematic basis over the periods that the related costs, for which it is  
intended to compensate, are expensed. Grants are disclosed as other income. R&D projects have  
been approved for SkatteFUNN for the period 2020 through 2022. The Group was awarded a grant  
from The Research Council of Norway (user-driven research-based innovation programme (BIA)) of  
up to NOK 13.8 million in total for the period June 2017 through June 2021 and per end of 2021 a total  
of NOK 13.4 million were received and recognised. Grant receivables as of year-end are disclosed in  
Note 18 Receivables.  
6
OPERATING SEGMENTS  
The Group has only one operating segment, which is research and development, and had no  
revenues for the reporting periods. All non-current assets are geographically located to Norway.  
7
STATEMENT OF COMPREHENSIVE INCOME ACCORDING TO CLASSIFICATION AND  
R&D EXPENSES BY CATEGORY  
Operating costs according to classification.  
(figures in NOK 1,000)  
Group  
Parent  
Note  
2022  
2021  
2022 2021  
Salary expenses  
8
21 968  
26 428
1 382
1 482  
Share option scheme, accounting effect  
8
-1 153  
12 549  
0
0
R&D exclusive salary and other operating expenses  
27 620  
43 595  
0
0
Depreciation and amortisation  
14,24  
6 406  
1 923  
0
0
Legal, audit, accounting, patents, and other fees*  
4 152  
4 722
2 517
2 380  
Other operating expenses  
2 205  
3 084
1 324
1 107  
Total operating expenses  
61 197  
92 302
5 222
4 969  
*Other fees relate to the Parent company which pays for management services performed by employees formally employed by  
the wholly-owned subsidiary, PCI Biotech AS.  
Of the total salary expenses NOK 11 526 relates to R&D activities (2021: NOK 17 369).  
R&D expenses by category:  
2022  
2021  
Clinical studies  
32 442  
57 204  
Pre-clinical studies  
7 257  
6 966  
CMC and equipment  
2 100  
3 332  
Patents  
2 958  
4 205  
Other expenses  
0
0
Total R&D expenses  
44 756  
71 707  
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991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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The Group has no development expenditure that qualifies for recognition of an asset under IAS 38 and  
intangible assets and all research expenditures are charged through the income statement, in line with  
previous years. A new batch of the product under development (fimaporfin) was produced in 2019 and  
an estimated cost value of fimaporfin in stock per year-end is NOK 2.5 million (2021: NOK 2.7 million).  
8
SALARY EXPENSES AND OTHER REMUNERATION  
(figures in NOK 1,000)  
Note  
Group  
Parent  
2022  
2021  
2022  
2021  
Wages and Board of Directors remuneration  
16 927  
21 255  
1 235  
1 340  
Social security contributions  
2 408  
2 805  
147  
142  
Share-based payments, incl social security  
-1 153  
12 549  
0
0
Pension costs  
9
2 276  
1 702  
0
0
Other expenses  
357  
666  
0
0
Total salary expenses  
20 814  
38 977  
1 382  
1 482  
No. of full-time equivalent positions  
10.4  
14.3  
0.0  
0.0  
Share option programme for employees  
Employees (including executive management) of the Group receive remuneration partly in the form of  
share-based payments, whereby employees render services as consideration for equity instruments  
(equity-settled transactions). The employees are employed in the subsidiary, PCI Biotech AS, and the  
share-based payment is thus accounted for as a P&L effect in the Group accounts and an investment  
in subsidiary in the parent company accounts. The general vesting term in the employee share option  
scheme is three years, with one third vested each year. The share options expire five years from grant  
date. All share options will lapse immediately upon the event that the employee's employment with the  
company is terminated. Each share option gives the right to subscribe for or acquire one share upon  
PCI Biotech Holding ASA's choice. The strike price is set at market terms and no premium for the  
share options are paid. The Black-Scholes method is used for fair value assessment of the share  
options at grant date. Further details about the share option program can be found in the Group  
remuneration policy.  
Valuation method for fair value assessment of share options granted  
The Black-Scholes method is used for fair value assessment of the share options at grant date.  
Volatility is calculated based on PCI Biotech’s own stock market valuation. The exercise price is set at  
market terms, equal to the average volume weighted share price last five days of trade prior to grant  
date (5 days VWAP), and no premium for the share options are paid. The risk-free interest rate is  
based on Norwegian 3-5 years government bond yield. Each option program is calculated separately  
with actual exercise price and lifetime for the program. The table below shows the input values used in  
the fair value assessment model at grant date.  
Fair value for all share options granted in 2022 were NOK 1.1 million (2021: NOK 7.5 million). The fair  
value estimated at grant date is amortised over the vesting period of three years.  
Share options granted in 2021 and 2022  
September 2021
November 2022  
Number of share options  
485 000  
570 000  
Dividend  
0
0
Historical volatility (%)  
132 %  
161 %  
Risk free interest rate (%)  
1.11%  
3.22 %  
Expected lifetime (years)  
5
4.8  
Expected level of vesting  
100%  
87%  
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991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
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Authorisation from the annual general meeting  
The general meeting held 28 May 2022 authorised the Board of Directors to grant the employees with  
a total of 2,790,000 share options and the authorisation applies for one year. 1,000,000 share options  
of the current authorisation have been granted by the Board of Directors at year-end 2022. The Board  
of Directors has not been granted any share options. See note 23 Related party transactions for  
further information.  
Share option transactions during the year  
In accordance with the authorisation granted by the Annual General Meeting 28 May 2022, the Board  
of Directors of PCI Biotech Holding ASA awarded a total of 570,000 share options to key employees  
on 25 November 2022. Each share option gives the right to subscribe for or acquire one share per  
option (after PCI Biotech Holding ASA’s choice), at a strike price of NOK 1.90, equal to the volume  
weighted average share price (VWAP) for the last 5 days of trade prior to the grant date. The share  
options are subject to other customary terms and conditions for employee incentive programs and the  
share options are lapsing in Q3 2027.  
The Black-Scholes method is used for fair value assessment of the share options at the grant date and  
the fair value was assessed to NOK 1.1 million, which will be charged to the profit and loss statement  
over the three-year vesting period if all share options are vested.  
Of the 570,000 share options, a total of 360,000 share options were allotted to the following primary  
insiders: 220,000 share options were allotted to Ronny Skuggedal, CEO/CFO. 120,000 share options  
were allotted to Anders Høgset, CSO. 20,000 share options were allotted to Kristin Eivindvik, CDO.  
Share option transactions during 2021  
In accordance with the authorisation granted by the Annual General Meeting 28 May 2021, the Board  
of Directors of PCI Biotech Holding ASA awarded a total of 485,000 share options to key employees  
on 6th September 2021. Each share option gives the right to subscribe for or acquire one share per  
option (after PCI Biotech Holding ASA’s choice), at a strike price of NOK 19.41, equal to the volume  
weighted average share price (VWAP) for the last 5 days of trade prior to the grant date. The share  
options are subject to other customary terms and conditions for employee incentive programs and the  
share options are lapsing in Q3 2026.  
The Black-Scholes method is used for fair value assessment of the share options at the grant date and  
the fair value was assessed to NOK 7.5 million, which will be charged to the profit and loss statement  
over the three-year vesting period if all share options are vested.  
Of the 485,000 share options, a total of 340,000 share options were allotted to the following primary  
insiders at that time: 70,000 share options were allotted to Per Walday, former CEO. 60,000 share  
options were allotted to Amir Snapir, former CMO. 50,000 share options were allotted to Ronny  
Skuggedal, CFO. 40,000 share options were allotted to Ludovic Robin, former CBO. 40,000 share  
options were allotted to Anders Høgset, CSO. 40,000 share options were allotted to Lucy Wabakken,  
former CDO (acting). 40,000 share options were allotted to Kristin Eivindvik, CDO. The share options  
awarded to former executives Walday, Snapir, Robin and Wabakken all lapsed during 2022.  
P&L and balance sheet accounting effects of the share option programme  
The net P&L accounting effect for share-based payments and corresponding social security liability  
following potential future share option exercises were a net reversal of costs of NOK 1.3 million (2021:  
net cost NOK 12.6 million). The net reversal of costs in 2022 is mainly due to downsizing, resulting  
from reduced expected number of vested share options. The potential social security liability for future  
exercises is calculated based upon share options that are in-the-money per reporting date and  
recognised as a short- or long-term liability in the balance sheet depending on vesting date of the  
underlying share options. No share options were in-the-money per year-end 2022 or 2021.  
For the parent company, PCI Biotech Holding ASA, a net amount of NOK -1.3 million for share based  
payments (2021: NOK +12.9 million) is recognised as adjustment of investment in subsidiary.  
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Share options outstanding at the end of the period have the following expiry date and exercise prices:  
Expiry date  
Exercise price in NOK per share  
Number of share options  
2021  
2022  
2022 - Q3  
21.48  
310 000  
-
2024 - Q3  
25.78  
300 000  
150 000  
2025 - Q3  
50.36  
520 000  
130 000  
2026 - Q3  
19.41  
485 000  
150 000  
2027 - Q3  
1.90  
-
570 000  
Total  
1 615 000  
1 000 000  
Options granted to employees, average exercise price and transactions during the year is listed below:  
2021  
2022  
Number  
Average  
Number Average  
exercise  
exercise  
price in  
price in  
NOK per  
NOK per  
share  
share  
Outstanding at the beginning of the year
1 185 000  
35.80 1
615 000  
30.96  
Granted during the year  
485 000  
19.41 570
000  
1.90  
Lapsed during the year  
55 000  
33.55 1
025 000  
32.42  
Exercised during the year  
0
-
0
-
Expired during the year  
0
-
160 000  
21.48  
Outstanding at year-end  
1 615 000  
30.96 1
000 000  
14.41  
Exercisable options at year-end  
683 333  
30.06 286
667  
32.10  
Exercise price and average remaining lifetime for outstanding options per year-end:  
Number of options 2021 / 2022  
Exercise price in  
Average remaining lifetime  
NOK per share  
(years)  
2021  
2022  
310 000 / 0  
21.48  
0.7  
-
300 000 / 150 000  
25.78  
2.7  
1.7  
520 000 / 130 000  
50.36  
3.7  
2.7  
485 000 / 150 000  
19.41  
4.7  
3.7  
0 / 570 000  
1.90  
-
4.7  
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9
PENSION EXPENSES  
(figures in NOK 1,000)  
Group  
2022  
2021  
Total pension cost from contribution schemes  
2 276  
1 702  
The contribution pension scheme is in compliance with Norwegian public requirements and a total of 9  
employees are included in the scheme at year-end 2022 (2021: 13 employees, in addition to one  
employee in a Finnish pension scheme, two employees in a Swedish pension scheme and one  
employee in a French pension scheme).  
10  
AUDITORS FEE  
AUDITOR FEES  
Group  
Parent  
(figures in NOK 1,000)  
2022  
2021  
2022  
2021  
Statutory audit  
374  
210  
296  
131  
Other assurance services  
81  
52  
0
8
Total  
455  
262  
296  
139  
11  
FINANCIAL INCOME AND EXPENSES  
(figures in NOK 1,000)  
Group  
Parent  
2022  
2021  
2022  
2021  
Interest income  
1 237  
640  
9
2
Interest income group company  
-
-
1 786  
1 591  
Other financial income  
474  
149  
1
0
Total financial income  
1 711  
789  
1 797  
1 593  
Interest expense  
49  
51  
33  
187  
Interest expense leasing  
78  
38  
0
0
Other financial expense  
232  
3 062  
463 783  
151 351  
Total financial expense  
359  
3 151  
463 816  
151 539  
For 2022 NOK 0.1 million in other financial expense (2021: NOK 2.5 million) in Parent and NOK 0.2  
million in other financial income (2021: NOK 2.5 million other financial expense) in Group were related  
to accounting effects of cash deposits in Euro per year-end, resulting from converting these Euro cash  
positions into NOK as functional currency for the annual accounts. The effects are reduced over time,  
due to general lower cash positions held in Euro.  
In 2021 and 2022 the parent company made a partial write-down of its investment in the wholly-owned  
subsidiary PCI Biotech AS, based on the observable fair value of the Group at Oslo Børs per year-  
end. The NOK 463.7 million write-down (2021: NOK 148.8 million) is disclosed as financial expenses  
for the parent company.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
42  
 
Enabling intracellular delivery  
12  
TAX  
(figures in NOK 1,000)  
Group  
Parent  
2022  
2021  
2022 2021  
Comprehensive income before tax  
-55 095
-88 391
-467 242
-154 915  
Expected nominal rate of tax (2022: 22% / 2021: 22%)  
-12 121
-19 446
-102 793  
-34 081  
Permanent differences charged through P&L  
-1 332  
1 803
102 793  
32 741  
Deferred tax asset not recognised in the balance sheet  
13 453  
17 643  
770  
1 340  
Total tax expense for the year  
0
0
0
0
Specification of basis for deferred tax asset / liability  
Tax effect of temporary differences:  
Group  
Parent  
2022  
2021  
2022  
2021  
Fixed assets  
-966  
64  
0
0
Receivables  
-14  
-11  
0
0
Carry forward loss  
-155 376
-142 957
-11 986  
-11 215  
Total tax asset (22% for 2022 / 22% for 2021)  
-156 357
-142 904
-11 986  
-11 215  
Deferred tax asset not recognised  
156 357
142 904  
11 986  
11 215  
Deferred tax asset recognised in the balance sheet  
0
0
0
0
The Group and Parent have no history of taxable profits and due to uncertainty of future utilisation,  
deferred tax assets have not been recognised in the balance sheets. The carry forward loss has no  
time limit according to current tax legislations.  
13  
EARNINGS PER SHARE  
Earnings per share for the Group (diluted earnings per share) are calculated on the basis of the  
financial result after tax for the year (financial result after tax for the year adjusted for dilutive effects)  
divided by a weighted average number of shares outstanding for the year (weighted average number  
of outstanding shares for the year adjusted for dilutive effects). Dilution effect is weighted number of  
outstanding share options which are in-the-money during the year. Accretive effects are not taken into  
consideration. Earnings per share are not affected by the dilution effect if negative results in the  
period.  
Earnings per share  
2022  
2021  
Weighted average number of shares (in '000)  
37 326  
37 326  
Net loss for the year  
-55 095  
-88 391  
Earnings per share (NOK per share)  
-1.48  
-2.37  
Dilution effect of in-the-money outstanding share options are not relevant as the result for the year is  
negative for 2022 and 2021.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
43  
 
Enabling intracellular delivery  
14  
FIXED ASSETS  
(figures in NOK 1,000)  
Group  
Office  
Device equipment
Total  
Acquisition cost per 1 January 2021  
9 268  
392 9
661  
Additions in 2021  
341  
0
341  
Disposals and scrapping during 2021  
0
0
0
Acquisition cost per 31 December 2021  
9 609  
392 10
001  
Additions in 2022  
0
0
0
Disposals and scrapping during 2022  
0
0
0
Acquisition cost per 31 December 2022  
9 609  
392 10
001  
Accumulated depreciation per 1 January 2021  
1 928  
343 2
272  
Ordinary depreciation 2021  
1 908  
16 1
923  
Disposals in 2021  
0
0
0
Accumulated depreciation per 31 December 2021  
3 836  
359 4
195  
Ordinary depreciation 2022  
0
16  
16  
Write-down 2022  
5 773  
0
5 773  
Disposals in 2022  
0
0
0
Accumulated depreciation per 31 December 2022  
9 609  
375 9
984  
Book value per 31 December 2021  
5 773  
33 5
806  
Book value per 31 December 2022  
0
18  
18  
The decision made in Q1 2022 to stop the RELEASE trial made the device (lasers) of no or low value  
and the carrying amount of NOK 5.8 million was depreciated in full in 2022.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
44  
 
Enabling intracellular delivery  
15  
SHARES IN SUBSIDIARIES – only relevant for the Parent company  
Equity  
participation Carrying  
Financial  
and share of
amount  
Equity  
result  
Year of  
Share capital  
voting  
(NOK  
(NOK  
(NOK  
Company  
acquisition  
of company  
rights  
thousand) thousand) thousand)  
PCI Biotech AS, Oslo -  
2008  
Norway  
Figures for 2022  
6 141 940  
100 %  
69 157  
50 506
-51 594  
Figures for 2021  
5 818 680  
100 %
504 191  
73 393
-82 293  
In 2022 the share capital of PCI Biotech AS was increased by NOK 323 260, with a share premium of  
NOK 29 676 740, totalling to NOK 30 000 000. The share capital was increased by a contribution in  
kind of intercompany balances of NOK 30 million by PCI Biotech Holding ASA.  
In 2021 the share capital of PCI Biotech AS was increased by NOK 323 260, with a share premium of  
NOK 39 676 740, totalling to NOK 40 000 000. The share capital was increased by a contribution in  
kind of intercompany balances of NOK 40 million by PCI Biotech Holding ASA.  
The carrying amount is assessed at the lowest of historic cost value and the observable market value  
of PCI Biotech at Oslo Børs. Per year-end the carrying amount is at fair value based on the observable  
market value of PCI Biotech at Oslo Børs. In 2022 and 2021 the parent company made a partial write-  
down of its investment in the wholly-owned subsidiary PCI Biotech AS, based on the observable fair  
value of the Group at Oslo Børs per year-end. The NOK 463.7 million write-down (2021: NOK 148.8  
million) is disclosed as financial expenses for the parent company.  
16  
FINANCIAL RISK  
This note describes the Group's various financial risks and the management of these. In addition,  
numerical tables for risk associated with financial risks are also presented.  
(I) Organisation of financial risk management  
PCI Biotech has an international business operation and is exposed to currency risk, interest risk,  
liquidity risk and credit risk. The Group has not utilised any derivatives or other financial instruments to  
reduce these risks during the accounting period. The responsibility for managing financial risk is at  
group level. The risk associated with centralised activities such as financing, interest rate and currency  
management is managed at group level. In addition, the group manages the risks associated with the  
business processes. The financial risk management is monitored by the Board of Directors.  
Centralised risk management  
PCI Biotech has a centralised risk management policy. The most important tasks within risk  
management are to ensure the Group's financial freedom to act both in a short- and long term  
perspective, and to monitor and manage financial risk in cooperation with the individual units in the  
group.  
Financial risk  
This section describes the most important risk factors within each business area and the management  
of these. In this context, financial risk is understood as risk associated with financial instruments.  
These can either be hedging instruments for underlying risk or be considered themselves as a source  
of risk. Market risk is not hedged with financial instruments.  
Research and development activities  
PCI Biotech carries out research and development for new innovative medical products based on the  
company’s patented technology. The currency risk in research and development is limited to the  
purchase of services, primarily related to clinical and pre-clinical studies. Foreign currency risk  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
45  
 
Enabling intracellular delivery  
associated with purchase of goods and services are foremost related to transactions in EUR and GBP.  
Foreign currency exposure associated with research and development is not normally hedged, but at  
year-end 2021 the Group had placed cash deposits in EURO to hedge the foreign currency risk for the  
RELEASE study. The study was terminated during 2022, and there are no material cash deposits in  
EURO at year-end 2022.  
(II) Classes of financial risk  
Interest rate risk  
Except for interest-bearing leasing liabilities, PCI Biotech does not have any interest-bearing debt, and  
the group’s interest rate risk is primarily associated with the Group’s cash positions and cash  
equivalents. This risk is managed at group level. The main strategy is to diversify the risk and invest in  
cash deposits with fixed or spot interest rates or money market funds with low risk, high liquidity and  
short duration. All funds are placed as cash deposits per year-end 2021 and 2022.  
Interest rate sensitivity  
Effect on financial result  
Group  
Parent  
Interest rate change  
2022  
2021  
2022  
2021  
+2%  
1 132  
2 322  
13  
530  
-2%  
-1 132  
-2 322  
-13  
-530  
Bank deposits  
+5%  
2 830  
5 806  
31  
1 324  
-5%  
-2 830  
-5 806  
-31  
-1 324  
Liquidity risk  
One of the most important objectives of PCI Biotech’s finance policy is to ensure that the Group has  
financial freedom to act in the short and long-term in order to attain strategic and operational goals.  
PCI Biotech shall have sufficient funds to cover expected capital requirements during the forthcoming  
12 month period in addition to a strategic reserve. Cash flow in research and development depends  
mainly on the activity level of the clinical programmes and the activity levels are adjustable without  
substantial long term commitments. The finance department monitors the cash flows in a short- and  
long term perspective. PCI Biotech’s most important source of finance are future royalty and milestone  
payments associated with licence agreements, government grants and the capital market. The biotech  
industry is a resource demanding industry, and drug development can be both labour and cash  
intensive. PCI Biotech being a pre-commercial stage biotech, means that the Company mainly relies  
on the ability to raise funds via the equity market and government grants for its development plans,  
and no assurance of the availability of resources for current and future drug development plans can be  
made. The capital market is used as a source of liquidity when this is appropriate and the conditions in  
these markets are competitive. The finance department continually evaluate other sources of  
financing. PCI Biotech does not have any debt agreements with key business ratio requirements  
(covenants).  
The cost base for the Company is reduced over time during 2022, mainly due to the closure of the  
RELEASE trial and implemented cost reduction matters during slimming down both the operational-  
and executive team. The cash position per year-end 2022 is on this basis estimated to enable a  
financial runway towards the end of 2024.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
46  
 
Enabling intracellular delivery  
Group (figures in NOK 1,000)  
Remaining period  
Less than
1-3 months
3-12 months
1-5 years
Total  
1 month  
31.12.2022  
Other long-term liabilities  
0
0
0
0
0
Long term-lease liabilities  
0
0
0
327  
327  
Trade accounts payables  
495  
0
0
0
495  
Current lease liabilities  
0
0
443  
0
443  
Public duties payables  
1 000  
81  
144  
0
1 225  
Other current liabilities  
67  
681  
2 842  
0
3 590  
Total liabilities  
1 562  
762  
3 429  
327 6
079  
31.12.2021  
Other long-term liabilities  
0
0
0
0
0
Long term lease liabilities  
0
0
0
1 277
1 277  
Trade accounts payables  
3 745  
0
0
0
3 745  
Current lease liabilities  
0
0
629  
0
629  
Public duties payables  
1 171  
542  
0
0
1 713  
Other current liabilities  
760  
3 398  
10 665  
0 14 823  
Total liabilities  
5 676  
3 940  
11 294  
1 277
22 186  
Other long-term liabilities relate to estimated social securities for potential future share option  
exercises in the Group’s remuneration incentive program.  
Parent (figures in NOK 1,000)  
Remaining period  
Less than
1-3 months
3-12 months
1-5 years
Total  
1 month  
31.12.2022  
Trade accounts payables  
Public duties payables  
Other current liabilities  
Total liabilities  
6
0
0
6
0
0
0
0
0
140  
990  
0
0
0
6
140  
990  
1 130  
0 1
136  
31.12.2021  
Trade accounts payables  
Public duties payables  
Other current liabilities  
Total liabilities  
19  
0
0
0
0
0
0
0
140  
990  
0
0
0
19  
140  
990  
19  
1 130  
0 1
149  
Credit risk  
PCI Biotech has no sales or receivable balances based on sales and faces therefore no credit risk.  
PCI Biotech has no need for monitoring of receivable balances based on sales and no bad debt  
provision has been recognised during 2022 or 2021. The majority of the Group’s financial assets are  
cash and cash equivalents and these funds are placed in cash deposits in different banks with  
satisfactory credit ratings. The credit risk for these funds is assessed to be low and no impairment test  
are performed for 2022 or 2021.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
47  
 
Enabling intracellular delivery  
Foreign currency risk  
As NOK is the Group’s functional currency, PCI Biotech is exposed to foreign currency risk associated  
with the Group’s foreign net exchange rate exposure. The Group’s expenses accrue in various  
currencies, primarily EUR and NOK. PCI Biotech is therefore exposed to fluctuations in foreign  
exchange rates. The Group evaluates whether measures should be taken to reduce the foreign  
currency risk through hedging for significant transactions and projects.  
The following table details the Group's and Parent company’s sensitivity to potential changes in the  
foreign currency exchange rate, with all other factors constant. The changes in exchange rates of  
+/10% is considered to be a reasonably possibly change. The calculation assumes an equal change in  
exchange rates against all relevant foreign currencies. The estimated effect on operating result is due  
to changes in value of monetary items in the balance sheet per year-end, with no effect on Other  
Comprehensive Income.  
Changes in exchange rates -
Effect on operating  
Euro  
result (NOK 1,000)  
Parent Group  
2022  
+/- 10 %  
+/- 0
+/- 29  
2021  
+/- 10 %  
+/- 2 647
+/- 1 811  
17  
CLASSIFICATIONS OF FINANCIAL ASSETS AND LIABILITIES  
The Group´s financial assets are governmental grant receivables, and the Group’s financial liabilities  
are accounts payables and other current liabilities. The Parent’s financial assets also include  
receivables from the wholly owned subsidiary, PCI Biotech AS. All these financial assets and liabilities  
are classified as financial instruments at amortised costs, and no financial assets or liabilities are  
classified at fair value through profit and loss.  
Financial assets and liabilities at amortised costs are measured at their nominal amount, as the  
nominal amount is assessed to be fair value due to the immaterial discounting effect for short-term  
maturities.  
18  
RECEIVABLES  
Receivables are measured by the amortised cost method, but due to the assets being short-term  
receivables the non-discounted contractual payments are disclosed. No credit losses allowance is  
recognised at year-end 2022 or 2021.  
Other current receivables - specification  
(Figures in NOK 1,000)  
Group  
Parent  
31.12.2022 31.12.2021
31.12.2022 31.12.2021  
Recognised not received government grants  
4 750  
4 750  
0
0
Prepaid payables  
0
7 096  
0
5
VAT receivables  
561  
354  
23  
28  
Recognised, not received interest from bank  
851  
0
0
0
Total other receivables  
6 162  
12 200  
23  
33  
The parent company has supported its wholly owned subsidiary, PCI Biotech AS, with loans and  
capital increases during the year. The capital increase during 2022 was NOK 30 million (2021: NOK  
40 million) and per year-end the loan balance is NOK 7.4 million (2021: NOK 15.0 million).  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
48  
 
Enabling intracellular delivery  
19  
CASH AND CASH EQUIVALENTS  
(Figures in NOK 1,000)  
Group  
Parent  
31.12.2022 31.12.2021
31.12.2022 31.12.2021  
Cash and cash equivalents, restricted (1)  
629  
938  
0
0
Cash and cash equivalents, non-restricted  
55 967  
115 180  
628  
26 476  
Total  
56 596  
116 118  
628  
26 476  
(1) Restricted cash and cash equivalents are security for the employees' withholding tax and bank deposits.  
The carrying amount of cash and cash equivalents is approximately equal to fair value since these  
instruments have a short term to maturity. The cash and cash equivalents are placed in cash deposits  
in NOK and EUR in different banks with satisfactory credit ratings. The credit risk for these funds is  
assessed to be low and no impairment test are performed for 2022 or 2021.  
20  
SHARE CAPITAL  
Nominal value  
per share in  
Share capital in  
No. of shares  
NOK  
NOK  
Share capital as per 31.12.2020  
37 326 390  
3,00  
111 979 170  
Share issues in 2021  
-
-
-
Share capital as per 31.12.2021  
37 326 390  
3,00  
111 979 170  
Share issues in 2022  
-
-
-
Share capital as per 31.12.2022  
37 326 390  
3,00  
111 979 170  
All shares have equal voting rights and otherwise have equal rights in the company and one share  
represents one voting right.  
Ordinary shares are classified as equity and only one class of shares exists. Expenses that are directly  
attributable to the issue of ordinary shares are disclosed as reduction of equity.  
The annual general meeting in May 2022 authorised the board of directors to execute share capital  
increases by issuing up to 2,790,000 shares with a nominal value of NOK 3.00 in connection with the  
company’s employee share option program. The authorisation is valid for one year. In addition, the  
board of directors was authorised to execute share capital increases with up to NOK 12,034,000 in  
connection with private placements. The authorisation shall not be used to increase share capital by  
an amount in excess of 10% of the share capital, based on the share capital per date of the  
authorisation and potential share capital increases in relation to the employee share option program.  
The authorisation may be used for general corporate purposes and is valid for one year.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
49  
 
Enabling intracellular delivery  
Ownership structure per 31 December 2022:  
Name  
No. of shares  
Ownership  
FONDSAVANSE AS  
3 910 443  
10.48 %  
MP PENSJON PK  
2 185 801  
5.86 %  
Myrlid AS  
2 034 463  
5.45 %  
RADFORSK INVESTERINGSSTIFTELSE  
1 082 415  
2.90 %  
GRESSLIEN  
938 800  
2.52 %  
Nordnet Bank AB  
809 677  
2.17 %  
CLEARSTREAM BANKING S.A.  
502 381  
1.35 %  
RAVI INVESTERING AS  
500 000  
1.34 %  
Jandersen Kapital AS  
470 000  
1.26 %  
BNP Paribas  
428 283  
1.15 %  
Total 10 largest shareholders  
12 862 263  
34.46%  
Others  
24 464 127  
65.54%  
Total  
37 326 390  
100.00%  
Shares owned, directly or indirectly, by members of the board and executive management, and their  
personally related parties per 31.12.2022 and per 31.12.2021:  
Number of shares  
Name  
Position  
31.12.2022  
31.12.2021  
Hans Peter Bøhn  
Chairman  
123 662  
123 662  
Lars Viksmoen  
Board member  
12 966  
12 966  
Christina Herder  
Board member  
10 000  
10 000  
Hilde Furberg (Borkenholm AS)*  
Board member  
8 000  
4 000  
Andrew Hughes  
Board member  
-
-
Anders Høgset  
CSO  
64 800  
64 800  
Ronny Skuggedal  
CFO  
55 000  
55 000  
Kristin Eivindvik  
CDO  
25 200  
25 200  
Per Walday**  
former CEO  
NA  
72 700  
Ludovic Robin***  
former CBO  
NA  
-
Amir Snapir****  
former CMO  
NA  
-
Total  
299 628  
368 336  
* Hilde Furberg’s shares are owned via Borkenholm AS, which is a related party to Hilde Furberg.  
** former CEO, Per Walday, left the company in May 2022.  
*** former CBO, Ludovic Robin, left the company in May 2022.  
**** former CMO, Amir Snapir, left the company in September 2022.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
50  
 
Enabling intracellular delivery  
21  
FINANCING STRUCTURE  
Except for interest-bearing leasing debt the Group had no external interest-bearing debt as of year-  
end 2022 or 2021.  
22  
OTHER CURRENT LIABILITIES BY YEAR END  
(Figures in NOK 1,000)  
Group  
Parent  
31.12.2022 31.12.2021
31.12.2022 31.12.2021  
Accruals for incurred external R&D expenses  
550  
8 721  
0
0
Accruals for employee bonus, holiday payments,  
board remuneration etc.  
2 820  
5 495  
990  
990  
Other accruals  
239  
0
0
0
Total other current liabilities  
3 609  
14 217  
990  
990  
Other current liabilities are measured by the amortised cost method, but due to the liabilities being  
short term liabilities the non-discounted contractual payments are disclosed. Other accruals per  
31.12.2022 represents accruals related to the downsizing process.  
23  
RELATED PARTIES TRANSACTIONS  
Figures for remuneration are expensed amounts in the financial year. All board remunerations are  
accounted for in the parent company.  
Executive remuneration (NOK 1,000)  
2022  
2021  
Management team remuneration  
11 088  
13 790  
Board of Director’s remuneration  
1 235  
1 235  
The Board of Directors’ remuneration consists only of board remuneration as approved by the annual  
general meeting. The Board of Director’s consisted of 5 persons for both 2021 and 2022.  
The management team per year-end 2022 consists of a combined CEO and CFO position, CSO and  
CDO, totaling 3 persons. The management team was downsized in 2022, to tailor management to  
current operations. The management team per year-end 2021 consisted of CEO, CFO, CSO, CMO,  
CBO, CDO, and acting CDO, totaling 7 persons. In relation to the downsizing in 2022, one member of  
the management team received termination payment accounting for 3 months additional notice period,  
and some employees outside of the management team received termination payment accounting for 1  
month additional notice period. These two elements are considered temporary deviations from the  
current remuneration guidelines.  
Please refer to the Remuneration Report 2022 for more information.  
Board  
Other Pension  
remuneration  
Salary Bonus
benefits benefits
Total  
Board of Directors 2022  
Hans Peter Bøhn, Chairman  
355  
0
0
0
0
355  
Hilde Furberg  
220  
0
0
0
0
220  
Christina Herder  
220  
0
0
0
0
220  
Lars Viksmoen  
220  
0
0
0
0
220  
Andrew Hughes  
220  
0
0
0
0
220  
Total remuneration  
1 235  
0
0
0
0
1 235  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
51  
 
Enabling intracellular delivery  
Board  
Other Pension  
remuneration  
Salary Bonus
benefits benefits
Total  
Board of Directors 2021  
Hans Peter Bøhn, Chairman  
355  
0
0
0
0
355  
Hilde Furberg  
220  
0
0
0
0
220  
Christina Herder  
220  
0
0
0
0
220  
Lars Viksmoen  
220  
0
0
0
0
220  
Andrew Hughes  
220  
0
0
0
0
220  
Total remuneration  
1 235  
0
0
0
0
1 235  
The senior executives participate in the Group’s pension plan that is a defined contribution plan which  
entails payment of 7% to 21% of the employee's annual salary up to 12 times the basic National  
Insurance amount (G). The pension scheme also covers in the event of disability.  
The CEO is entitled to six months' notice and has an agreement of additional 6 months’ salary on  
certain terms. There are no agreements beyond the statutory requirements for other senior executives.  
Senior executives have not received any remuneration or financial benefits from other companies in  
the Group other than those disclosed above. It is not given additional remuneration for special services  
outside the normal functions of a senior executive.  
There are no loans or pledges to senior executives, board of directors, employees or other persons in  
elected corporate bodies. For more details about PCI Biotech’s remuneration policy, please see the  
established guidelines on the determination of salaries and other remuneration of executive  
management in accordance with § 6–16a of the Norwegian Public Companies Act.  
Senior executive’s shareholdings in PCI Biotech Holding ASA are disclosed in note 20 Share capital.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
52  
 
Enabling intracellular delivery  
Allocation, exercise and holdings of share options in the Company for senior executives are presented  
in the table below:  
Average  
Total  
Total  
exercise  
Overview share options,  
holdings  
holdings price
in  
Senior executives  
31.12.2021 Allocated Lapsed Exercised Expired 31.12.2022  
NOK  
Ronny Skuggedal, CEO / CFO  
190 000  
220 000  
0
0
50 000  
360 000  
13.72  
Anders Høgset, CSO  
190 000  
120 000  
0
0
60 000  
250 000  
18.21  
Kristin Eivindvik, PD  
110 000  
20 000  
0
0
20 000  
110 000  
21.36  
Per Walday, former CEO*  
295 000  
0 295
000  
0
0
0
-
Ludovic Robin, former CBO**  
130 000  
0 130
000  
0
0
0
-
Amir Snapir, former CMO***  
150 000  
0 150
000  
0
0
0
-
Lucy Wabakken, former acting CDO****  
160 000  
0 160
000  
0
0
0
-
Total  
1 225 000  
360 000
735 000  
0 130
000  
720 000  
*former CEO, P.Walday left the company in May 2022  
**former CBO, L.Robin left the company in May 2022  
***former CMO, A.Snapir left the company in September 2022  
****former acting CDO, L.Wabakken worked as acting CDO during 2021 and into 2022  
Related parties:  
Helpyou2 Ltd.  
In 2022 the Group had regular business transactions with Helpyou2 Ltd. a UK based company owned  
by Prof. Andrew Hughes, a Director in PCI Biotech Holding ASA. The services rendered concern Prof.  
Hughes position as member of the Scientific Advisory Committee (‘SAC’), and related agreed scientific  
consultancies by Prof. Hughes during the year. The services rendered are pre-approved by the Board  
of Directors and regular fee overviews are presented for the Board of Directors. Helpyou2 Ltd. has not  
received any fees for services related to the SAC for 2022 or 2021. For other agreed scientific  
consultancies, Helpyou2 Ltd. received NOK 15 thousand in fees for 2022 (2021: NOK 24 thousand). It  
is in management and the Board of Director’s opinion that the service fee is based on ‘arm’s length’  
principles and the level of consultancy is not considered to constitute a threat to independence for the  
parties in 2022 or 2021.  
PCI Biotech AS:  
The parent company, PCI Biotech Holding ASA, has no employees. The Group operations are  
managed through the wholly-owned subsidiary PCI Biotech AS that has a management service  
agreement with the parent company, including services like management, offices, finance and investor  
relation functions for the Group. All transactions are performed at market terms.  
The parent company has been charged for operations according to the service agreement of NOK 2.1  
million in 2022 (2021: NOK 2.2 million). The parent company has charged PCI Biotech AS interest  
expenses for intercompany loans of NOK 1.8 million during 2022 (2021: NOK 1.6 million). Net current  
receivables from PCI Biotech AS at year-end 2022 were NOK 7.4 million (2021: NOK 15.0 million). In  
2022 an intercompany loan to PCI Biotech AS of NOK 30 million was utilised as contribution in kind  
from PCI Biotech Holding ASA for a capital increase in PCI Biotech AS.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
53  
 
Enabling intracellular delivery  
24  
RIGHT TO USE ASSETS AND LEASE LIABILITIES  
PCI Biotech has entered into a lease agreement with Oslo Cancer Cluster Incubator, Ullernchausséen  
64 Oslo, Norway. The lease originally runs to 31 December 2021, with an option for three more years.  
PCI Biotech exercised the lease option and the lease now runs to 31 December 2024. The lease  
agreement is subject to annual adjustment according to changes in the consumer price index. In  
December 2022 the lease office space was reduced, and the right to use asset and future lease  
obligations are reduced accordingly. Amounts of minimum lease payment for the non-cancellable  
operating lease is NOK 0.8 million (discounted contractual payments) per year-end 2022 (2021: NOK  
1.9 million), applying an incremental borrowing rate of 12% (2021: 6%).  
Payments for the principal portion of the lease liabilities are not charged to profit and loss and will only  
have cash flow effects.  
Right to use asset - office lease  
Accumulated recognition 31.12.2019  
1 815  
Acquisitions FY 2020  
0
Acquisitions FY 2021  
1 867  
Acquisitions FY 2022  
0
Disposals FY2022  
-531  
Accumulated acquisition costs 31.12.2021  
3 682  
Accumulated acquisition costs 31.12.2022  
3 151  
Depreciation FY 2019  
604  
Depreciation FY 2020  
605  
Depreciation FY 2021  
620  
Depreciation FY 2022  
618  
Accumulated depreciation and impairment as of 31.12.2021  
1 829  
Accumulated depreciation and impairment as of 31.12.2022  
2 447  
Total right to use assets – office lease as of 31.12.2021  
1 854  
Total right to use assets – office lease as of 31.12.2022  
705  
Lower of remaining lease term or economic life - 2021  
3.0 years  
Lower of remaining lease term or economic life - 2022  
2.0 years  
Depreciation method  
Linear  
Lease liabilities - office  
Accumulated recognition 31.12.19  
1 196  
Recognition during 2020  
0
Recognition during 2021  
1 867  
De-recognition during 2022  
-531  
Accumulated recognition 31.12.21  
3 063  
Accumulated recognition 31.12.22  
2 532  
Payments principal portion of the lease liability FY 2020  
-668  
Payments principal portion of the lease liability FY 2021  
-672  
Payments principal portion of the lease liability FY 2022  
-682  
Interest expenses on the lease liability FY 2020  
144  
Interest expenses on the lease liability FY 2021  
40  
Interest expenses on the lease liability FY 2022  
76  
Total lease liabilities for office as of 31.12.2021  
1 906  
Total lease liabilities for office as of 31.12.2022  
770  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
54  
 
Enabling intracellular delivery  
Whereof:  
Short term lease liabilities < 1 year 2021 / 2022  
629 / 443  
Long term lease liabilities > 1 year 2021 / 2022  
1 277 / 327  
The Group applies the short-term lease recognition exemption for leases related to office equipment,  
parking facilities at the office and a flat in Oslo available for disposition for foreign employees. Lease  
payments for this category of leases are consequently charged directly through profit and loss.  
Income statement effects leasing  
2022  
2021  
Depreciation of right to use asset  
-618  
-620  
Effect on Operating results net of tax  
-618  
-620  
Interest expenses on the lease liabilities  
-76  
-40  
Effect on Net financial result net of tax  
-694  
-660  
Comprehensive income effect net of tax  
-694  
-660  
The Group had total cash outflows related to leases of NOK 0.8 million in 2022 (2021: NOK 1.0  
million). Minimum nominal payments for non-cancellable payments for all leases are NOK 1.0 million  
per year-end 2022 (2021: NOK 0.7 million).  
25  
SUBSEQUENT EVENTS  
PCI Biotech is not aware of any other subsequent events since year-end 2022 which are of material  
significance to the financial statements as of 31 December 2022.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no:
991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
55  
 
Foretaksregisteret: NO 976 389 387 MVA  
Tlf: +47 24 00 24 00  
Statsautoriserte revisorer  
Ernst & Young AS  
www.ey.no  
Medlemmer av Den norske Revisorforening  
Dronning Eufemias gate 6a, 0191 Oslo  
Postboks 1156 Sentrum, 0107 Oslo  
INDEPENDENT AUDITOR'S REPORT  
To the Annual Shareholders' Meeting of Pci Biotech Holding ASA  
Opinion  
We have audited the financial statements of Pci Biotech Holding ASA (the Company), which comprise the  
financial statements of the Company and the consolidated financial statements of the Company and its  
subsidiaries (the Group). The financial statements of the Company and the Group comprise the balance  
sheet as at 31 December 2022, the statement of comprehensive income, statement of cash flows and  
statement of changes in equity for the year then ended, and notes to the financial statements, including a  
summary of significant accounting policies.  
In our opinion the financial statements comply with applicable legal requirements and give a true and fair  
view of the financial position of the Company and the Group as at 31 December 2022 and their financial  
performance and cash flows for the year then ended in accordance with International Financial Reporting  
Standards as adopted by the EU.  
Our opinion is consistent with our additional report to the audit committee.  
Basis for opinion  
We conducted our audit in accordance with International Standards on Auditing (ISAs). Our  
responsibilities under those standards are further described in the Auditor’s responsibilities for the audit of  
the financial statements section of our report. We are independent of the Company and the Group in  
accordance with the requirements of the relevant laws and regulations in Norway and the International  
Ethics Standards Board for Accountants’ International Code of Ethics for Professional Accountants  
(including International Independence Standards) (IESBA Code), and we have fulfilled our other ethical  
responsibilities in accordance with these requirements. We believe that the audit evidence we have  
obtained is sufficient and appropriate to provide a basis for our opinion.  
To the best of our knowledge and belief, no prohibited non-audit services referred to in the Audit  
Regulation (537/2014) Article 5.1 have been provided.  
oumtnøkel:AHY0GO6D25VWT-PBJCI  
We have been the auditor of the Company for 16 years from the election by the general meeting of the  
shareholders on 17. desember 2007 for the accounting year 2007.  
Key audit matters  
Key audit matters are those matters that, in our professional judgment, were of most significance in our  
audit of the financial statements for 2022. We have determined that there are no key audit matters to  
communicate in our report.  
Other information  
Other information consists of the information included in the annual report other than the financial  
statements and our auditor’s report thereon. Management (the board of directors and the Chief Executive  
Officer) is responsible for the other information. Our opinion on the financial statements does not cover  
the other information, and we do not express any form of assurance conclusion thereon.  
In connection with our audit of the financial statements, our responsibility is to read the other information,  
and, in doing so, consider whether the board of directors’ report contains the information required by legal  
requirements and whether the other information is materially inconsistent with the financial statements or  
our knowledge obtained in the audit, or otherwise appears to be materially misstated. If, based on the  
A member firm of Ernst & Young Global Limited  
 
2
work we have performed, we conclude that there is a material misstatement of this other information or  
that the information required by legal requirements is not included, we are required to report that fact.  
We have nothing to report in this regard, and in our opinion, the board of directors’ report, the statement  
on corporate governance and the statement on corporate social responsibility are consistent with the  
financial statements and contain the information required by applicable legal requirements.  
Responsibilities of management for the financial statements  
Management is responsible for the preparation and fair presentation of the financial statements in  
accordance with International Financial Reporting Standards as adopted by the EU, and for such internal  
control as management determines is necessary to enable the preparation of financial statements that  
are free from material misstatement, whether due to fraud or error.  
In preparing the financial statements, management is responsible for assessing the Company’s and the  
Group’s ability to continue as a going concern, disclosing, as applicable, matters related to going concern  
and using the going concern basis of accounting unless management either intends to liquidate the  
Company or the Group, or to cease operations, or has no realistic alternative but to do so.  
Auditor’s responsibilities for the audit of the financial statements  
Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are  
free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that  
includes our opinion. Reasonable assurance is a high level of assurance, but is not a guarantee that an  
audit conducted in accordance with ISAs will always detect a material misstatement when it exists.  
Misstatements can arise from fraud or error and are considered material if, individually or in the  
aggregate, they could reasonably be expected to influence the economic decisions of users taken on the  
basis of these financial statements.  
As part of an audit in accordance with ISAs, we exercise professional judgment and maintain professional  
scepticism throughout the audit. We also:  
Identify and assess the risks of material misstatement of the financial statements, whether due to  
fraud or error, design and perform audit procedures responsive to those risks, and obtain audit  
evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not  
detecting a material misstatement resulting from fraud is higher than for one resulting from error,  
as fraud may involve collusion, forgery, intentional omissions, misrepresentations, or the override  
of internal control.  
oumtnøkel:AHY0GO6D25VWT-PBJCI  
Obtain an understanding of internal control relevant to the audit in order to design audit  
procedures that are appropriate in the circumstances, but not for the purpose of expressing an  
opinion on the effectiveness of the Company’s and the Group’s internal control.  
Evaluate the appropriateness of accounting policies used and the reasonableness of accounting  
estimates and related disclosures made by management.  
Conclude on the appropriateness of management’s use of the going concern basis of accounting  
and, based on the audit evidence obtained, whether a material uncertainty exists related to  
events or conditions that may cast significant doubt on the Company’s and the Group’s ability to  
continue as a going concern. If we conclude that a material uncertainty exists, we are required to  
draw attention in our auditor’s report to the related disclosures in the financial statements or, if  
such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit  
evidence obtained up to the date of our auditor’s report. However, future events or conditions  
may cause the Company and the Group to cease to continue as a going concern.  
Evaluate the overall presentation, structure and content of the financial statements, including the  
disclosures, and whether the financial statements represent the underlying transactions and  
events in a manner that achieves fair presentation.  
Independent auditor's report - Pci Biotech Holding ASA 2022  
A member firm of Ernst & Young Global Limited  
 
3
Obtain sufficient appropriate audit evidence regarding the financial information of the entities or  
business activities within the Group to express an opinion on the consolidated financial  
statements. We are responsible for the direction, supervision and performance of the group audit.  
We remain solely responsible for our audit opinion.  
We communicate with the board of directors regarding, among other matters, the planned scope and  
timing of the audit and significant audit findings, including any significant deficiencies in internal control  
that we identify during our audit.  
We also provide the audit committee with a statement that we have complied with relevant ethical  
requirements regarding independence, and to communicate with them all relationships and other matters  
that may reasonably be thought to bear on our independence, and where applicable, related safeguards.  
From the matters communicated with the board of directors, we determine those matters that were of  
most significance in the audit of the financial statements of the current period and are therefore the key  
audit matters. We describe these matters in our auditor’s report unless law or regulation precludes public  
disclosure about the matter or when, in extremely rare circumstances, we determine that a matter should  
not be communicated in our report because the adverse consequences of doing so would reasonably be  
expected to outweigh the public interest benefits of such communication.  
Report on other legal and regulatory requirement  
Report on compliance with regulation on European Single Electronic Format (ESEF)  
Opinion  
As part of the audit of the financial statements of PCI Biotech Holding ASA we have performed an  
assurance engagement to obtain reasonable assurance about whether the financial statements included  
in the annual report, with the file name pcibiotechholdingasa-2022-12-31-en, have been prepared, in all  
material respects, in compliance with the requirements of the Commission Delegated Regulation (EU)  
2019/815 on the European Single Electronic Format (ESEF Regulation) and regulation pursuant to  
Section 5-5 of the Norwegian Securities Trading Act, which includes requirements related to the  
preparation of the annual report in XHTML format and iXBRL tagging of the consolidated financial  
statements.  
oumtnøkel:AHY0GO6D25VWT-PBJCI  
In our opinion, the financial statements, included in the annual report, have been prepared, in all material  
respects, in compliance with the ESEF Regulation.  
Management’s responsibilities  
Management is responsible for the preparation of the annual report in compliance with the ESEF  
Regulation. This responsibility comprises an adequate process and such internal control as management  
determines is necessary.  
Auditor’s responsibilities  
Our responsibility, based on audit evidence obtained, is to express an opinion on whether, in all material  
respects, the financial statements included in the annual report have been prepared in accordance with  
the ESEF Regulation. We conduct our work in accordance with the International Standard for Assurance  
Engagements (ISAE) 3000 – “Assurance engagements other than audits or reviews of historical financial  
information”. The standard requires us to plan and perform procedures to obtain reasonable assurance  
about whether the financial statements included in the annual report have been prepared in accordance  
with the ESEF Regulation.  
As part of our work, we perform procedures to obtain an understanding of the company’s processes for  
preparing the financial statements in accordance with the ESEF Regulation. We test whether the financial  
Independent auditor's report - Pci Biotech Holding ASA 2022  
A member firm of Ernst & Young Global Limited  
 
4
statements are presented in XHTML-format. We evaluate the completeness and accuracy of the iXBRL  
tagging of the consolidated financial statements and assess management’s use of judgement. Our  
procedures include reconciliation of the iXBRL tagged data with the audited financial statements in  
human-readable format. We believe that the evidence we have obtained is sufficient and appropriate to  
provide a basis for our opinion.  
Oslo, 27th of April 2023  
ERNST & YOUNG AS  
The auditor's report is signed electronically  
Tommy Romskaug  
State Authorised Public Accountant (Norway)  
oumtnøkel:AHY0GO6D25VWT-PBJCI  
Independent auditor's report - Pci Biotech Holding ASA 2022  
A member firm of Ernst & Young Global Limited  
 
Enabling intracellular delivery  
OTHER INFORMATION  
DEFINITIONS AND GLOSSARY  
Amphinex:  
BIA:  
CSR:  
Trade name of the clinical intravenous formulation of fimaporfin  
User-driven research-based innovation program by the Research Council of Norway  
Corporate Social Responsibility  
Fimaporfin:  
fimaChem  
fimaNAC:  
fimaVACC:  
IFRS:  
Generic name of the photosensitiser active ingredient TPCS2a  
Previous development program for enhancement of generic chemotherapies  
Development program for PCI Biotech’s technology for delivery of nucleic acids  
Development program for PCI Biotech’s immune therapy technology  
International Financial Report Standards  
ICI:  
Immune Checkpoint Inhibitor  
In vitro:  
Studies performed with cells or biological molecules studied outside their normal  
biological context; for example proteins are examined in solution, or cells in  
artificial culture medium.  
In vivo:  
Studies in which the effects of various biological entities are tested on whole,  
living organisms usually animals.  
NAA:  
Norwegian Accounting Act  
PCI:  
Photochemical internalisation  
PCIB:  
RELEASE:  
R&D:  
PCI Biotech’s ticker at Oslo Børs  
Name of PCI Biotech’s pivotal study for inoperable extrahepatic bile duct cancer  
Research and Development  
SAC:  
Scientific Advisory Committee  
FINANCIAL CALENDAR  
First quarter 2023 report  
12 May 2023  
Ordinary general meeting 2023  
Second quarter 2023 report  
Third quarter 2023 report  
25 May 2023  
31 August 2023  
22 November 2023  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
60  
 
Enabling intracellular delivery  
INVESTOR CONTACT  
Contact person: Ronny Skuggedal, email: rs@pcibiotech.no mob: +47 9400 5757  
Web: www.pcibiotech.com  
FORWARD LOOKING STATEMENTS  
This Report contains certain forward-looking statements relating to the business, financial  
performance and results of the Company and/or the industry in which it operates. Forward-looking  
statements concern future circumstances and results and other statements that are not historical facts,  
and are sometimes identified by the words “believes”, expects”, “predicts”, “intends”, “projects”,  
“plans”, “estimates”, “aims”, “foresees”, “anticipates”, “targets”, and similar expressions. The forward-  
looking statements contained in this Report, including assumptions, opinions and views of the  
Company or cited from third party sources, are solely opinions and forecasts which are subject to  
risks, uncertainties and other factors that may cause the actual results, performance or achievements  
of the Company to be materially different from any future results, performance or achievements that  
are expressed or implied by statements and information in the Report, including, among others, risks  
or uncertainties associated with the Company’s business, segments, development, growth  
management, financing, market acceptance and relations with customers, and, more generally,  
general economic and business conditions, changes in domestic and foreign laws and regulations,  
taxes, changes in competition and pricing environments, and fluctuations in currency exchange rates  
and interest rates. None of the Company or any of its subsidiaries or any such person’s directors,  
employees or advisors provide any assurance that the assumptions underlying forward-looking  
statements expressed in this Report are free from errors nor does any of them accept any  
responsibility for the future accuracy of such forward-looking statements.  
PCI Biotech Holding ASA, Ullernchausséen 64, 0379 Oslo, Norway, Company no: 991036393 VAT  
Phone: + 47 67 11 54 00, www.pcibiotech.com  
61  
 
PCI BIOTECH AS, subsꢁdꢁꢀrꢂ  
Ullernchꢀusséen 64  
PCI BIOTECH HOLDING ASA  
Ullernchꢀusséen 64  
N-0379 Oslo, Norwꢀꢁ  
Phone: +47 67 11 54 00  
emꢀꢂl: post@pcꢁbꢁotech.com  
web: www.pcꢁbꢁotech.com  
N-0379 Oslo, Norwꢀꢁ