<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:38609ac4-0c56-41dc-9e4a-1956cbea0904,g:3ef90608-34ba-4368-930c-656b1b0c3856-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.ipsen.com/role/StatementofcomprehensiveincomeprofitorlossbynatureofexpenseStatement" xlink:type="simple" xlink:href="ipsen-2023-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbynatureofexpenseStatement"/>
  <link:calculationLink xlink:role="http://www.ipsen.com/role/StatementofcomprehensiveincomeprofitorlossbynatureofexpenseStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_439ac21a-2b3d-4f49-8583-e5cda82f7a0a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_439ac21a-2b3d-4f49-8583-e5cda82f7a0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales_363d6b81-6f93-4bb7-9eae-6566c888cdee" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CostOfSales"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_CostOfSales_363d6b81-6f93-4bb7-9eae-6566c888cdee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SellingExpense_c88c23d4-29bd-4909-a9ac-3f8ed5006dc9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SellingExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_SellingExpense_c88c23d4-29bd-4909-a9ac-3f8ed5006dc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_b68529ba-e041-4746-b3e4-5fcf495bd69f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_b68529ba-e041-4746-b3e4-5fcf495bd69f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_682eea6c-56e1-46ba-9394-ca7d24c11814" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_682eea6c-56e1-46ba-9394-ca7d24c11814" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_903b0b46-d179-47be-a5b0-ec6cbd08babd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_903b0b46-d179-47be-a5b0-ec6cbd08babd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_313c655c-196b-44fd-895a-69d83d892b04" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_313c655c-196b-44fd-895a-69d83d892b04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseOfRestructuringActivities_5da75b00-782e-4400-8508-4ca5e3fd55d3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ExpenseOfRestructuringActivities"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_ExpenseOfRestructuringActivities_5da75b00-782e-4400-8508-4ca5e3fd55d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_3e37f9f0-15bc-47f8-bf30-320d07002341" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_e8d216f8-42f8-41e4-87c8-b63b85bbbd88" xlink:to="loc_ifrs-full_ImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_3e37f9f0-15bc-47f8-bf30-320d07002341" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_6e0cd8f6-27fb-4232-b16b-66748bb08dc8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromSaleOfGoods_dae349d7-7889-442f-af8a-e91ae6532d32" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromSaleOfGoods"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueFromContractsWithCustomers_6e0cd8f6-27fb-4232-b16b-66748bb08dc8" xlink:to="loc_ifrs-full_RevenueFromSaleOfGoods_dae349d7-7889-442f-af8a-e91ae6532d32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherRevenue_2cdfcd1f-f31b-4c75-8ca3-88b992964f7c" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherRevenue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_RevenueFromContractsWithCustomers_6e0cd8f6-27fb-4232-b16b-66748bb08dc8" xlink:to="loc_ifrs-full_OtherRevenue_2cdfcd1f-f31b-4c75-8ca3-88b992964f7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_a6bbaaec-aa30-4d93-84cb-32a7fc1b8a5d" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_0160da73-488d-4bf1-b6fa-524d790e2e6f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossFromDiscontinuedOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_a6bbaaec-aa30-4d93-84cb-32a7fc1b8a5d" xlink:to="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_0160da73-488d-4bf1-b6fa-524d790e2e6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_9eeaeb78-82ea-4806-8f5d-840910940db8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_a6bbaaec-aa30-4d93-84cb-32a7fc1b8a5d" xlink:to="loc_ifrs-full_ProfitLossFromContinuingOperations_9eeaeb78-82ea-4806-8f5d-840910940db8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_6d974285-d216-4fc4-afee-511657f7b778" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_a3643afb-5c08-411d-86e1-bda45c057ed1" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_6d974285-d216-4fc4-afee-511657f7b778" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_a3643afb-5c08-411d-86e1-bda45c057ed1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherFinanceIncomeCost_320a3abe-f9f2-4802-b397-20f4f66d37a5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherFinanceIncomeCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_6d974285-d216-4fc4-afee-511657f7b778" xlink:to="loc_ifrs-full_OtherFinanceIncomeCost_320a3abe-f9f2-4802-b397-20f4f66d37a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_2b749027-e95b-4293-888d-e176b774dbc9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_6d974285-d216-4fc4-afee-511657f7b778" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_2b749027-e95b-4293-888d-e176b774dbc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_ad3b0a69-030a-4acd-9c79-4ecc51808f64" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_6d974285-d216-4fc4-afee-511657f7b778" xlink:to="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_ad3b0a69-030a-4acd-9c79-4ecc51808f64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestRevenueExpense_36fa4b34-f03f-4842-9383-66ec723acd86" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestRevenueExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations_6d974285-d216-4fc4-afee-511657f7b778" xlink:to="loc_ifrs-full_InterestRevenueExpense_36fa4b34-f03f-4842-9383-66ec723acd86" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ipsen.com/role/StatementofcomprehensiveincomeprofitorlossbynatureofexpenseStatement_1" xlink:type="simple" xlink:href="ipsen-2023-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbynatureofexpenseStatement_1"/>
  <link:calculationLink xlink:role="http://www.ipsen.com/role/StatementofcomprehensiveincomeprofitorlossbynatureofexpenseStatement_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_5216def7-7224-4b1e-ab7d-93499d2b55ca" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_9a0ba81e-6cb0-49ef-9569-e9da15fac8a2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_5216def7-7224-4b1e-ab7d-93499d2b55ca" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_9a0ba81e-6cb0-49ef-9569-e9da15fac8a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_c722edc1-3b02-4150-9eb6-79592a3b5dc8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_5216def7-7224-4b1e-ab7d-93499d2b55ca" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_c722edc1-3b02-4150-9eb6-79592a3b5dc8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ipsen.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement" xlink:type="simple" xlink:href="ipsen-2023-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement"/>
  <link:calculationLink xlink:role="http://www.ipsen.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_706f6ada-4f03-475d-9dc2-6b2ba852cc30" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeFromContinuingOperations_558471c4-4ebf-4b8f-872d-d46dccd8bf69" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_706f6ada-4f03-475d-9dc2-6b2ba852cc30" xlink:to="loc_ifrs-full_ComprehensiveIncomeFromContinuingOperations_558471c4-4ebf-4b8f-872d-d46dccd8bf69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeFromDiscontinuedOperations_008d0218-b2b5-4d22-aa00-7d7df73349cc" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeFromDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_706f6ada-4f03-475d-9dc2-6b2ba852cc30" xlink:to="loc_ifrs-full_ComprehensiveIncomeFromDiscontinuedOperations_008d0218-b2b5-4d22-aa00-7d7df73349cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_e4359153-b516-4635-8086-68ab8138059e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_fee8523f-261c-43d9-8ad8-03cde5af2a41" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_e4359153-b516-4635-8086-68ab8138059e" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_fee8523f-261c-43d9-8ad8-03cde5af2a41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_1d3d197e-84ef-4949-861e-9a266bf64575" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_e4359153-b516-4635-8086-68ab8138059e" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_1d3d197e-84ef-4949-861e-9a266bf64575" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_be9140b6-f624-48d7-88cc-7e09ef972afc" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_VariationDeJusteValeurDesInstrumentsDeCouvertureNetteDimpots_dc5970f6-6c5f-439d-8ad1-1f1f8861fe34" xlink:href="ipsen-2023-12-31.xsd#ipsen_VariationDeJusteValeurDesInstrumentsDeCouvertureNetteDimpots"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_be9140b6-f624-48d7-88cc-7e09ef972afc" xlink:to="loc_ipsen_VariationDeJusteValeurDesInstrumentsDeCouvertureNetteDimpots_dc5970f6-6c5f-439d-8ad1-1f1f8861fe34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_7ee5450c-b0b4-4284-a5f5-7de292d3abde" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_be9140b6-f624-48d7-88cc-7e09ef972afc" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation_7ee5450c-b0b4-4284-a5f5-7de292d3abde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_b2da8d9f-50ea-4eb9-9acc-61078701ff71" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_7a4ff7e5-f442-4bee-a0c0-e207c3873acb" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_b2da8d9f-50ea-4eb9-9acc-61078701ff71" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_7a4ff7e5-f442-4bee-a0c0-e207c3873acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments_1963b526-a941-4a2d-a431-6df3a8ed474f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_b2da8d9f-50ea-4eb9-9acc-61078701ff71" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeNetOfTaxGainsLossesFromInvestmentsInEquityInstruments_1963b526-a941-4a2d-a431-6df3a8ed474f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ipsen.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1" xlink:type="simple" xlink:href="ipsen-2023-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1"/>
  <link:calculationLink xlink:role="http://www.ipsen.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_e8ced4e0-e81a-4da5-968d-12f6c95babf8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_1d28c7de-9793-4386-9af4-7308364accdb" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_e8ced4e0-e81a-4da5-968d-12f6c95babf8" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_1d28c7de-9793-4386-9af4-7308364accdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_17615631-6a56-42b5-b8b5-9cc0251df51c" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_e8ced4e0-e81a-4da5-968d-12f6c95babf8" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_17615631-6a56-42b5-b8b5-9cc0251df51c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_9b25ec43-67d0-43c8-b0fa-854968a6733a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_AutresElementsDuResultatGlobalDesActivitesCedees_250e14bb-d266-4f38-8da9-aa6155fe4528" xlink:href="ipsen-2023-12-31.xsd#ipsen_AutresElementsDuResultatGlobalDesActivitesCedees"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_9b25ec43-67d0-43c8-b0fa-854968a6733a" xlink:to="loc_ipsen_AutresElementsDuResultatGlobalDesActivitesCedees_250e14bb-d266-4f38-8da9-aa6155fe4528" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_AutresElementsDuResultatGlobalDesActivitesPoursuivies_1dd38af8-9703-472c-87f3-61bb4623c3d7" xlink:href="ipsen-2023-12-31.xsd#ipsen_AutresElementsDuResultatGlobalDesActivitesPoursuivies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_9b25ec43-67d0-43c8-b0fa-854968a6733a" xlink:to="loc_ipsen_AutresElementsDuResultatGlobalDesActivitesPoursuivies_1dd38af8-9703-472c-87f3-61bb4623c3d7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ipsen.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_2" xlink:type="simple" xlink:href="ipsen-2023-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_2"/>
  <link:calculationLink xlink:role="http://www.ipsen.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxStatement_2" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_cc6d9d75-3fee-4234-b4d0-699cb86300aa" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_51d4bdc8-3a35-4814-a0a3-76e06c68bd13" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_cc6d9d75-3fee-4234-b4d0-699cb86300aa" xlink:to="loc_ifrs-full_ProfitLoss_51d4bdc8-3a35-4814-a0a3-76e06c68bd13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_9f8c37ca-ef81-4d53-9a59-e94ee4d8595e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_cc6d9d75-3fee-4234-b4d0-699cb86300aa" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_9f8c37ca-ef81-4d53-9a59-e94ee4d8595e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ipsen.com/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="simple" xlink:href="ipsen-2023-12-31.xsd#StatementoffinancialpositioncurrentnoncurrentStatement"/>
  <link:calculationLink xlink:role="http://www.ipsen.com/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_076cc650-f69f-4c88-92c1-71245f09cdbd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_44ee40c6-b2d2-469e-aaf8-8a0e529c53b2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_076cc650-f69f-4c88-92c1-71245f09cdbd" xlink:to="loc_ifrs-full_NoncurrentLiabilities_44ee40c6-b2d2-469e-aaf8-8a0e529c53b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_b1a01d01-1147-4bd9-8a29-0520bc4719fd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_076cc650-f69f-4c88-92c1-71245f09cdbd" xlink:to="loc_ifrs-full_CurrentLiabilities_b1a01d01-1147-4bd9-8a29-0520bc4719fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_19b363ce-383b-4f24-bf59-d5e9380e0ac3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_076cc650-f69f-4c88-92c1-71245f09cdbd" xlink:to="loc_ifrs-full_Equity_19b363ce-383b-4f24-bf59-d5e9380e0ac3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_d6120015-a1a2-4f00-b60b-2bd5c022996e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_0699e9cc-f0e4-4bd6-af66-f52b27f479e9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_d6120015-a1a2-4f00-b60b-2bd5c022996e" xlink:to="loc_ifrs-full_NoncurrentAssets_0699e9cc-f0e4-4bd6-af66-f52b27f479e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_a141ec94-1ac6-4087-b3cf-2c6f6169e85f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_d6120015-a1a2-4f00-b60b-2bd5c022996e" xlink:to="loc_ifrs-full_CurrentAssets_a141ec94-1ac6-4087-b3cf-2c6f6169e85f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_8713b806-20f5-419c-bd1a-c8645df5a7ca" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions_db6d3119-79c5-405b-9e22-d6c07d07b872" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentProvisions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_8713b806-20f5-419c-bd1a-c8645df5a7ca" xlink:to="loc_ifrs-full_CurrentProvisions_db6d3119-79c5-405b-9e22-d6c07d07b872" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_7cfb43d4-bdd5-41d2-8b72-73c72b57d89c" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_8713b806-20f5-419c-bd1a-c8645df5a7ca" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_7cfb43d4-bdd5-41d2-8b72-73c72b57d89c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities_3ab76e90-204f-4206-82a2-9189dec4e948" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_8713b806-20f5-419c-bd1a-c8645df5a7ca" xlink:to="loc_ifrs-full_OtherCurrentLiabilities_3ab76e90-204f-4206-82a2-9189dec4e948" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_51db1b69-deeb-434c-96c9-c83b6bf86db6" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_8713b806-20f5-419c-bd1a-c8645df5a7ca" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_51db1b69-deeb-434c-96c9-c83b6bf86db6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BankOverdraftsClassifiedAsCashEquivalents_3bfd54b9-f131-40f2-9b32-56e037182820" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_BankOverdraftsClassifiedAsCashEquivalents"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_8713b806-20f5-419c-bd1a-c8645df5a7ca" xlink:to="loc_ifrs-full_BankOverdraftsClassifiedAsCashEquivalents_3bfd54b9-f131-40f2-9b32-56e037182820" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_PassifsFinanciersCourantsIncluantLesDettesDeLocation_c7431898-7088-47bb-8413-75ed0f54c242" xlink:href="ipsen-2023-12-31.xsd#ipsen_PassifsFinanciersCourantsIncluantLesDettesDeLocation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_8713b806-20f5-419c-bd1a-c8645df5a7ca" xlink:to="loc_ipsen_PassifsFinanciersCourantsIncluantLesDettesDeLocation_c7431898-7088-47bb-8413-75ed0f54c242" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_f2e45bff-f09a-4561-bb0d-c43962fdde6f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_586454a4-469e-455b-8e4a-2e4b9dbdccc5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_f2e45bff-f09a-4561-bb0d-c43962fdde6f" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_586454a4-469e-455b-8e4a-2e4b9dbdccc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarningsProfitLossForReportingPeriod_8daaa5c1-867d-4ef6-81c6-57d446674969" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RetainedEarningsProfitLossForReportingPeriod"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_f2e45bff-f09a-4561-bb0d-c43962fdde6f" xlink:to="loc_ifrs-full_RetainedEarningsProfitLossForReportingPeriod_8daaa5c1-867d-4ef6-81c6-57d446674969" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_d9573ee6-b026-46cd-b1b3-4d3435567580" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_f2e45bff-f09a-4561-bb0d-c43962fdde6f" xlink:to="loc_ifrs-full_IssuedCapital_d9573ee6-b026-46cd-b1b3-4d3435567580" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_PrimesEtReservesConsolidees_73ab99dd-1cab-4bbc-a7ab-054ad3581870" xlink:href="ipsen-2023-12-31.xsd#ipsen_PrimesEtReservesConsolidees"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_f2e45bff-f09a-4561-bb0d-c43962fdde6f" xlink:to="loc_ipsen_PrimesEtReservesConsolidees_73ab99dd-1cab-4bbc-a7ab-054ad3581870" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_07feb93a-62eb-4237-b7be-7d3d5e5768f6" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_6f8acc54-2996-404b-bf3c-b40a8e43ccee" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_07feb93a-62eb-4237-b7be-7d3d5e5768f6" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_6f8acc54-2996-404b-bf3c-b40a8e43ccee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_ee7cbd4b-4e00-458b-a846-c39f7c81b605" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_07feb93a-62eb-4237-b7be-7d3d5e5768f6" xlink:to="loc_ifrs-full_NoncontrollingInterests_ee7cbd4b-4e00-458b-a846-c39f7c81b605" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentFinancialAssets_595cad54-90e4-48d2-9fd0-1cf962f5d862" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherNoncurrentFinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ifrs-full_OtherNoncurrentFinancialAssets_595cad54-90e4-48d2-9fd0-1cf962f5d862" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_33b65c97-bb77-4e50-a758-0ac28dd1bd76" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InvestmentAccountedForUsingEquityMethod"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_33b65c97-bb77-4e50-a758-0ac28dd1bd76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_c8fd4f18-00b0-4527-a14e-8f0c30104581" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ifrs-full_DeferredTaxAssets_c8fd4f18-00b0-4527-a14e-8f0c30104581" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_ImmobilisationsCorporellesIncluantLesDroitsDutilisation_53a67913-619c-4533-b70e-ba03139d7e78" xlink:href="ipsen-2023-12-31.xsd#ipsen_ImmobilisationsCorporellesIncluantLesDroitsDutilisation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ipsen_ImmobilisationsCorporellesIncluantLesDroitsDutilisation_53a67913-619c-4533-b70e-ba03139d7e78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_3349f2cd-ed01-4c91-ac94-61bb2e804644" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ifrs-full_Goodwill_3349f2cd-ed01-4c91-ac94-61bb2e804644" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_2c8eae89-a75b-4579-b008-6c228d9b022c" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ifrs-full_NoncurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_2c8eae89-a75b-4579-b008-6c228d9b022c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_66725b82-343d-419b-adeb-bb60be115740" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_66725b82-343d-419b-adeb-bb60be115740" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_394133ce-317a-40f1-9f12-2eb02416aa75" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_b67682a7-0bb5-48cf-a02a-736fe4f34f6b" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_394133ce-317a-40f1-9f12-2eb02416aa75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_539b4fda-3e43-4e8b-a664-27c201dbf464" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_2f9a956c-34e2-45bd-811b-a132e3ddf408" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentProvisionsForEmployeeBenefits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_539b4fda-3e43-4e8b-a664-27c201dbf464" xlink:to="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_2f9a956c-34e2-45bd-811b-a132e3ddf408" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentLiabilities_0ee0c196-ef82-46eb-bbcf-b0fca64da6f7" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherNoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_539b4fda-3e43-4e8b-a664-27c201dbf464" xlink:to="loc_ifrs-full_OtherNoncurrentLiabilities_0ee0c196-ef82-46eb-bbcf-b0fca64da6f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherLongtermProvisions_e99df034-6683-4eff-8389-f6ac7b138ddd" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherLongtermProvisions"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_539b4fda-3e43-4e8b-a664-27c201dbf464" xlink:to="loc_ifrs-full_OtherLongtermProvisions_e99df034-6683-4eff-8389-f6ac7b138ddd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_PassifsFinanciersNonCourantsIncluantLesDettesDeLocation_61239996-51f5-4b50-84d7-8d60e088f00f" xlink:href="ipsen-2023-12-31.xsd#ipsen_PassifsFinanciersNonCourantsIncluantLesDettesDeLocation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_539b4fda-3e43-4e8b-a664-27c201dbf464" xlink:to="loc_ipsen_PassifsFinanciersNonCourantsIncluantLesDettesDeLocation_61239996-51f5-4b50-84d7-8d60e088f00f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_b33fc444-19e5-40dc-a2d3-f1fb82ae4ff8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_539b4fda-3e43-4e8b-a664-27c201dbf464" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_b33fc444-19e5-40dc-a2d3-f1fb82ae4ff8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_f0c6a13a-a616-4890-8ccc-c601286c9954" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentFinancialAssets_09a7c067-befd-4a6f-9f7c-41811d735386" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherCurrentFinancialAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_f0c6a13a-a616-4890-8ccc-c601286c9954" xlink:to="loc_ifrs-full_OtherCurrentFinancialAssets_09a7c067-befd-4a6f-9f7c-41811d735386" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_c867c2ef-6e78-4957-afc1-879393c24e83" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Inventories"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_f0c6a13a-a616-4890-8ccc-c601286c9954" xlink:to="loc_ifrs-full_Inventories_c867c2ef-6e78-4957-afc1-879393c24e83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_8e2c9801-9d18-435e-9c9e-044e44547a67" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_f0c6a13a-a616-4890-8ccc-c601286c9954" xlink:to="loc_ifrs-full_CashAndCashEquivalents_8e2c9801-9d18-435e-9c9e-044e44547a67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_313877aa-0359-4a47-bd91-d0814625725b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_f0c6a13a-a616-4890-8ccc-c601286c9954" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_313877aa-0359-4a47-bd91-d0814625725b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTradeReceivables_b7c3e69a-4222-4ddf-8915-6f64375409e1" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTradeReceivables"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_f0c6a13a-a616-4890-8ccc-c601286c9954" xlink:to="loc_ifrs-full_CurrentTradeReceivables_b7c3e69a-4222-4ddf-8915-6f64375409e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentAssets_b2cbebd6-9cb4-4697-84c2-de28011b4032" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherCurrentAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_f0c6a13a-a616-4890-8ccc-c601286c9954" xlink:to="loc_ifrs-full_OtherCurrentAssets_b2cbebd6-9cb4-4697-84c2-de28011b4032" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ipsen.com/role/StatementofcashflowsindirectmethodStatement" xlink:type="simple" xlink:href="ipsen-2023-12-31.xsd#StatementofcashflowsindirectmethodStatement"/>
  <link:calculationLink xlink:role="http://www.ipsen.com/role/StatementofcashflowsindirectmethodStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_c9916afe-8b06-4270-b5e1-2ecb494befef" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_c9916afe-8b06-4270-b5e1-2ecb494befef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_AjustementResultatActivitesCedees_846a8fe7-9bb7-46a6-85e5-55df39a519a4" xlink:href="ipsen-2023-12-31.xsd#ipsen_AjustementResultatActivitesCedees"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ipsen_AjustementResultatActivitesCedees_846a8fe7-9bb7-46a6-85e5-55df39a519a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsForNoncashItems_21239cc7-2698-40b6-8513-71dc3f48615b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherAdjustmentsForNoncashItems"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_OtherAdjustmentsForNoncashItems_21239cc7-2698-40b6-8513-71dc3f48615b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_832cb054-8d33-4016-b390-cdce3362828f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_832cb054-8d33-4016-b390-cdce3362828f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_326916a1-4fa9-4167-bf34-57dffae2f6eb" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_326916a1-4fa9-4167-bf34-57dffae2f6eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_AjustementCoutDeLaDetteNette_92bafd2f-f809-4ce6-bf9f-2de16095fae2" xlink:href="ipsen-2023-12-31.xsd#ipsen_AjustementCoutDeLaDetteNette"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ipsen_AjustementCoutDeLaDetteNette_92bafd2f-f809-4ce6-bf9f-2de16095fae2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_5062d810-62e6-4d64-890f-d9b0f96846da" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncomeTaxExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_5062d810-62e6-4d64-890f-d9b0f96846da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_5da0be0c-df4d-4ca1-8c6c-8d5786c66488" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_ProfitLoss_5da0be0c-df4d-4ca1-8c6c-8d5786c66488" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_954829c4-85f2-4f91-a084-bec03c0f8415" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_954829c4-85f2-4f91-a084-bec03c0f8415" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_7b94bca3-f7c5-4140-8082-75cd681276fb" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains_7b94bca3-f7c5-4140-8082-75cd681276fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_AmortissementsEtProvisions_6a10a91e-f9ab-4658-9b3f-4e24deab94ba" xlink:href="ipsen-2023-12-31.xsd#ipsen_AmortissementsEtProvisions"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_1507cab5-4db7-434a-9066-81cbc76b7d35" xlink:to="loc_ipsen_AmortissementsEtProvisions_6a10a91e-f9ab-4658-9b3f-4e24deab94ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities_30590f79-f7bc-4544-a958-4b2c80ed130f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities_30590f79-f7bc-4544-a958-4b2c80ed130f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities_2fbe908a-c547-4dfa-902f-2a6f7a63a200" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities_2fbe908a-c547-4dfa-902f-2a6f7a63a200" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfCurrentBorrowings_b25d1d77-50ae-4a9a-ae0e-8547d2b2daaf" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RepaymentsOfCurrentBorrowings"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_RepaymentsOfCurrentBorrowings_b25d1d77-50ae-4a9a-ae0e-8547d2b2daaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingShares_32061118-96bd-44cc-b37c-296068fc3838" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromIssuingShares"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_ProceedsFromIssuingShares_32061118-96bd-44cc-b37c-296068fc3838" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_6bb535f1-209f-47b6-8abf-bccabe3d4269" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestPaidClassifiedAsFinancingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_6bb535f1-209f-47b6-8abf-bccabe3d4269" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_TitresDautocontrole_df372ac7-e41d-4695-b877-2f52200a2231" xlink:href="ipsen-2023-12-31.xsd#ipsen_TitresDautocontrole"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ipsen_TitresDautocontrole_df372ac7-e41d-4695-b877-2f52200a2231" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_PaiementsConditionnelsLiesADesAcquisitions_cc98dd9e-f853-4957-a949-a36896ed466e" xlink:href="ipsen-2023-12-31.xsd#ipsen_PaiementsConditionnelsLiesADesAcquisitions"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ipsen_PaiementsConditionnelsLiesADesAcquisitions_cc98dd9e-f853-4957-a949-a36896ed466e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromCurrentBorrowings_62856c88-f2a5-41fd-b8c8-1e6334452463" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromCurrentBorrowings"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_ProceedsFromCurrentBorrowings_62856c88-f2a5-41fd-b8c8-1e6334452463" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_f7ec5d9d-f29f-44c8-aa54-c8c4f9023ed4" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromNoncurrentBorrowings"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_f7ec5d9d-f29f-44c8-aa54-c8c4f9023ed4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_70c5756f-5e33-4443-ab21-1e14616e4198" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RepaymentsOfNoncurrentBorrowings"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_70c5756f-5e33-4443-ab21-1e14616e4198" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_VariationDuBesoinEnFondsDeRoulementLieAuxOperationsDeFinancement_0f2d58e8-0601-4d5c-ab8f-5d84dd730f7a" xlink:href="ipsen-2023-12-31.xsd#ipsen_VariationDuBesoinEnFondsDeRoulementLieAuxOperationsDeFinancement"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c60032c8-9841-47e5-be44-e28ba9f1fc58" xlink:to="loc_ipsen_VariationDuBesoinEnFondsDeRoulementLieAuxOperationsDeFinancement_0f2d58e8-0601-4d5c-ab8f-5d84dd730f7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_301068bd-8c85-419b-9175-a4c21ae89d01" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_c8e0917e-fe79-4ef5-881f-031072e3cd28" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_301068bd-8c85-419b-9175-a4c21ae89d01" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_c8e0917e-fe79-4ef5-881f-031072e3cd28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_20103cae-0198-40e6-aee2-c43a90327cec" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_301068bd-8c85-419b-9175-a4c21ae89d01" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_20103cae-0198-40e6-aee2-c43a90327cec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_5b2a0339-eb87-4b0a-acbf-bb2317440181" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_301068bd-8c85-419b-9175-a4c21ae89d01" xlink:to="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_5b2a0339-eb87-4b0a-acbf-bb2317440181" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_04e7fd55-53e3-4445-9f40-22a9e45f93f3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_56f7340f-796d-462d-8190-a41326fa6073" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInInventories"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_04e7fd55-53e3-4445-9f40-22a9e45f93f3" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_56f7340f-796d-462d-8190-a41326fa6073" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_VariationNetteDesAutresActifsEtPassifsLiesALactivite_8225b18e-28b7-4563-92bb-c521c6742365" xlink:href="ipsen-2023-12-31.xsd#ipsen_VariationNetteDesAutresActifsEtPassifsLiesALactivite"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_04e7fd55-53e3-4445-9f40-22a9e45f93f3" xlink:to="loc_ipsen_VariationNetteDesAutresActifsEtPassifsLiesALactivite_8225b18e-28b7-4563-92bb-c521c6742365" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_0f871ac5-b941-4ea2-b49b-162d954b57ba" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_04e7fd55-53e3-4445-9f40-22a9e45f93f3" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_0f871ac5-b941-4ea2-b49b-162d954b57ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable_e945b7db-c099-40fa-894a-0e07cf057fe9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInWorkingCapital_04e7fd55-53e3-4445-9f40-22a9e45f93f3" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable_e945b7db-c099-40fa-894a-0e07cf057fe9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_0d8f055a-2f04-4e78-b61e-b77facd9b5ec" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:to="loc_ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_0d8f055a-2f04-4e78-b61e-b77facd9b5ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_VariationsDePerimetre_366721b1-3b2e-4bdc-bdcb-b02e37b372fd" xlink:href="ipsen-2023-12-31.xsd#ipsen_VariationsDePerimetre"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:to="loc_ipsen_VariationsDePerimetre_366721b1-3b2e-4bdc-bdcb-b02e37b372fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_AcquisitionsDimmobilisationsCorporellesHorsDettes_3029b511-9d65-4c94-a6f2-b226157791d8" xlink:href="ipsen-2023-12-31.xsd#ipsen_AcquisitionsDimmobilisationsCorporellesHorsDettes"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:to="loc_ipsen_AcquisitionsDimmobilisationsCorporellesHorsDettes_3029b511-9d65-4c94-a6f2-b226157791d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_AcquisitionsDimmobilisationsIncorporellesHorsDetteSurImmo_4eec9ccb-b82b-478e-b378-34b94b35f193" xlink:href="ipsen-2023-12-31.xsd#ipsen_AcquisitionsDimmobilisationsIncorporellesHorsDetteSurImmo"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:to="loc_ipsen_AcquisitionsDimmobilisationsIncorporellesHorsDetteSurImmo_4eec9ccb-b82b-478e-b378-34b94b35f193" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ipsen_VariationDuBesoinEnFondsDeRoulementLieAuxOperationsDinvestissement_a299bc4c-430d-4e35-9f76-e073596fb46f" xlink:href="ipsen-2023-12-31.xsd#ipsen_VariationDuBesoinEnFondsDeRoulementLieAuxOperationsDinvestissement"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:to="loc_ipsen_VariationDuBesoinEnFondsDeRoulementLieAuxOperationsDinvestissement_a299bc4c-430d-4e35-9f76-e073596fb46f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsInvestingActivities_f1ea7997-06fa-4b72-ab50-60005ada75cf" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsInvestingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsInvestingActivities_f1ea7997-06fa-4b72-ab50-60005ada75cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_7ef994f9-1405-4a04-9c5e-a74a48b6e24b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_e0b1e587-11ec-409d-9d85-e6abbb754f76" xlink:to="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_7ef994f9-1405-4a04-9c5e-a74a48b6e24b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_36ef176d-60e1-422a-bb92-93109801e6a8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_75ab6fca-57c2-43e9-a9e9-abde52f7a8cc" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_36ef176d-60e1-422a-bb92-93109801e6a8" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_75ab6fca-57c2-43e9-a9e9-abde52f7a8cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fe9d83bd-9f1a-49f7-ae77-2e6ed3c2d682" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_36ef176d-60e1-422a-bb92-93109801e6a8" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_fe9d83bd-9f1a-49f7-ae77-2e6ed3c2d682" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5d5abfb3-2e46-462e-8e82-1f09cd160b90" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_36ef176d-60e1-422a-bb92-93109801e6a8" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_5d5abfb3-2e46-462e-8e82-1f09cd160b90" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
