<?xml version="1.0"?>
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-210000" xlink:type="simple" xlink:href="exail-2022-12-31.xsd#ias_1_role-210000" />
  <link:roleRef roleURI="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-320000" xlink:type="simple" xlink:href="exail-2022-12-31.xsd#ias_1_role-320000" />
  <link:roleRef roleURI="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-420000" xlink:type="simple" xlink:href="exail-2022-12-31.xsd#ias_1_role-420000" />
  <link:roleRef roleURI="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-610000" xlink:type="simple" xlink:href="exail-2022-12-31.xsd#ias_1_role-610000" />
  <link:roleRef roleURI="http://www.esma.europa.eu/xbrl/role/all/ias_7_role-520000" xlink:type="simple" xlink:href="exail-2022-12-31.xsd#ias_7_role-520000" />
  <link:calculationLink xlink:role="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-210000" xlink:type="extended">
    <link:loc xlink:label="loc_-210000_2_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Assets" xlink:type="locator" />
    <link:loc xlink:label="loc_-210000_5_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAssetsOtherThanAssetsOrDisposalGroupsClassifiedAsHeldForSaleOrAsHeldForDistributionToOwners" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_2_1" xlink:to="loc_-210000_5_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_27_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_2_1" xlink:to="loc_-210000_27_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_28_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_2_1" xlink:to="loc_-210000_28_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_3_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalents" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_5_1" xlink:to="loc_-210000_3_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_7_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentContractAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_5_1" xlink:to="loc_-210000_7_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_12_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxAssetsCurrent" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_5_1" xlink:to="loc_-210000_12_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_14_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTradeReceivables" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_5_1" xlink:to="loc_-210000_14_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_21_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Inventories" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_5_1" xlink:to="loc_-210000_21_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_32_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_5_1" xlink:to="loc_-210000_32_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_33_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentFinancialAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_5_1" xlink:to="loc_-210000_33_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_10_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLiabilitiesOtherThanLiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale" xlink:type="locator" />
    <link:loc xlink:label="loc_-210000_6_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentBorrowingsAndCurrentPortionOfNoncurrentBorrowings" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_6_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_8_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentContractLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_8_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_9_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLeaseLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_9_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_11_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentProvisions" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_11_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_13_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_13_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_34_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentFinancialLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_34_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_35_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCurrentLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_35_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_41_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_10_1" xlink:to="loc_-210000_41_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_17_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAndLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_17_1" xlink:to="loc_-210000_10_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_18_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParent" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_17_1" xlink:to="loc_-210000_18_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_24_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_17_1" xlink:to="loc_-210000_24_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_26_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncontrollingInterests" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_17_1" xlink:to="loc_-210000_26_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_30_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_17_1" xlink:to="loc_-210000_30_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_1_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdditionalPaidinCapital" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_18_1" xlink:to="loc_-210000_1_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_23_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapital" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_18_1" xlink:to="loc_-210000_23_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_RetainedEarningsAndConsolidatedNetIncome" xlink:href="exail-2022-12-31.xsd#exail_RetainedEarningsAndConsolidatedNetIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_18_1" xlink:to="exail_RetainedEarningsAndConsolidatedNetIncome" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_15_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DeferredTaxAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_15_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_19_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Goodwill" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_19_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_20_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_20_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_22_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InvestmentsInAssociatesAccountedForUsingEquityMethod" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_22_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_36_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_36_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_37_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentFinancialAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_37_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_39_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PropertyPlantAndEquipment" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_39_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_40_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RightofuseAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_27_1" xlink:to="loc_-210000_40_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_4_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CommitmentsInRelationToJointVentures" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_30_1" xlink:to="loc_-210000_4_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_16_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DeferredTaxLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_30_1" xlink:to="loc_-210000_16_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_25_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LongtermBorrowings" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_30_1" xlink:to="loc_-210000_25_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_29_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLeaseLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_30_1" xlink:to="loc_-210000_29_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_31_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentProvisions" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_30_1" xlink:to="loc_-210000_31_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-210000_38_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentLiabilities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-210000_30_1" xlink:to="loc_-210000_38_1" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-320000" xlink:type="extended">
    <link:loc xlink:label="loc_-320000_3_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceIncomeCost" xlink:type="locator" />
    <link:loc xlink:label="loc_-320000_6_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherFinanceCost" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_3_1" xlink:to="loc_-320000_6_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-320000_7_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherFinanceIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_3_1" xlink:to="loc_-320000_7_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_CostOfNetDebt" xlink:href="exail-2022-12-31.xsd#exail_CostOfNetDebt" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_3_1" xlink:to="exail_CostOfNetDebt" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-320000_9_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss" xlink:type="locator" />
    <link:loc xlink:label="loc_-320000_10_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromContinuingOperations" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_9_1" xlink:to="loc_-320000_10_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-320000_11_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromDiscontinuedOperations" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_9_1" xlink:to="loc_-320000_11_1" xlink:type="arc" weight="1" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_10_1" xlink:to="loc_-320000_3_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-320000_4_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_10_1" xlink:to="loc_-320000_4_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-320000_12_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_10_1" xlink:to="loc_-320000_12_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-320000_14_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAccountedForUsingEquityMethod" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_12_1" xlink:to="loc_-320000_14_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_OperatingResults" xlink:href="exail-2022-12-31.xsd#exail_OperatingResults" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_12_1" xlink:to="exail_OperatingResults" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_OtherOperatingIncomeItems" xlink:href="exail-2022-12-31.xsd#exail_OtherOperatingIncomeItems" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-320000_12_1" xlink:to="exail_OtherOperatingIncomeItems" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-320000_5_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestIncomeOnCashAndCashEquivalents" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CostOfNetDebt" xlink:to="loc_-320000_5_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_InterestOnGrossDebt" xlink:href="exail-2022-12-31.xsd#exail_InterestOnGrossDebt" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CostOfNetDebt" xlink:to="exail_InterestOnGrossDebt" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-320000_1_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ChangesInInventoriesOfFinishedGoodsAndWorkInProgress" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="loc_-320000_1_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-320000_2_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EmployeeBenefitsExpense" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="loc_-320000_2_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-320000_8_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherWorkPerformedByEntityAndCapitalised" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="loc_-320000_8_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-320000_13_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueFromContractsWithCustomers" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="loc_-320000_13_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-320000_15_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxExpenseOtherThanIncomeTaxExpense" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="loc_-320000_15_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="exail_DepreciationAmortisationExpensesAndProvisionExpensesNetOfReversals" xlink:href="exail-2022-12-31.xsd#exail_DepreciationAmortisationExpensesAndProvisionExpensesNetOfReversals" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="exail_DepreciationAmortisationExpensesAndProvisionExpensesNetOfReversals" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="exail_OtherIncomeFromOperations" xlink:href="exail-2022-12-31.xsd#exail_OtherIncomeFromOperations" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="exail_OtherIncomeFromOperations" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_OtherOperatingIncomeAndExpenses" xlink:href="exail-2022-12-31.xsd#exail_OtherOperatingIncomeAndExpenses" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="exail_OtherOperatingIncomeAndExpenses" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_PurchasesAndExternalCharges" xlink:href="exail-2022-12-31.xsd#exail_PurchasesAndExternalCharges" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_OperatingResults" xlink:to="exail_PurchasesAndExternalCharges" xlink:type="arc" weight="-1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-420000" xlink:type="extended">
    <link:loc xlink:label="loc_-420000_1_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome" xlink:type="locator" />
    <link:loc xlink:label="loc_-420000_5_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_1_1" xlink:to="loc_-420000_5_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-420000_9_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_1_1" xlink:to="loc_-420000_9_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-420000_2_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxRelatingToExchangeDifferencesOnTranslationOfOtherComprehensiveIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_5_1" xlink:to="loc_-420000_2_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-420000_3_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxRelatingToFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_5_1" xlink:to="loc_-420000_3_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-420000_4_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_5_1" xlink:to="loc_-420000_4_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-420000_6_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxExchangeDifferencesOnTranslation" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_5_1" xlink:to="loc_-420000_6_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-420000_7_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxFinancialAssetsMeasuredAtFairValueThroughOtherComprehensiveIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_5_1" xlink:to="loc_-420000_7_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-420000_8_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_5_1" xlink:to="loc_-420000_8_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-420000_10_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ShareOfOtherComprehensiveIncomeOfAssociatesAndJointVenturesAccountedForUsingEquityMethodThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-420000_5_1" xlink:to="loc_-420000_10_1" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.esma.europa.eu/xbrl/role/all/ias_1_role-610000" xlink:type="extended">
    <link:loc xlink:label="loc_-610000_1_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome" xlink:type="locator" />
    <link:loc xlink:label="loc_-610000_3_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-610000_1_1" xlink:to="loc_-610000_3_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-610000_4_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-610000_1_1" xlink:to="loc_-610000_4_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_EquityRestated" xlink:href="exail-2022-12-31.xsd#exail_EquityRestated" xlink:type="locator" />
    <link:loc xlink:label="loc_-610000_2_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_EquityRestated" xlink:to="loc_-610000_2_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_ImpactIfrs19" xlink:href="exail-2022-12-31.xsd#exail_ImpactIfrs19" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_EquityRestated" xlink:to="exail_ImpactIfrs19" xlink:type="arc" weight="1" />
  </link:calculationLink>
  <link:calculationLink xlink:role="http://www.esma.europa.eu/xbrl/role/all/ias_7_role-520000" xlink:type="extended">
    <link:loc xlink:label="loc_-520000_4_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:type="locator" />
    <link:loc xlink:label="loc_-520000_8_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DividendsPaidClassifiedAsFinancingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_4_1" xlink:to="loc_-520000_8_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_13_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestPaidClassifiedAsFinancingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_4_1" xlink:to="loc_-520000_13_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_15_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_4_1" xlink:to="loc_-520000_15_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_16_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromBorrowingsClassifiedAsFinancingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_4_1" xlink:to="loc_-520000_16_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_17_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromIssuingShares" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_4_1" xlink:to="loc_-520000_17_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_22_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RepaymentsOfBorrowingsClassifiedAsFinancingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_4_1" xlink:to="loc_-520000_22_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="exail_NetCashInflowOuflowTreasurySharesAndNonControllingTransactions" xlink:href="exail-2022-12-31.xsd#exail_NetCashInflowOuflowTreasurySharesAndNonControllingTransactions" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_4_1" xlink:to="exail_NetCashInflowOuflowTreasurySharesAndNonControllingTransactions" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_5_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:type="locator" />
    <link:loc xlink:label="loc_-520000_19_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfAvailableforsaleFinancialAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_5_1" xlink:to="loc_-520000_19_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_20_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_5_1" xlink:to="loc_-520000_20_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_21_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_5_1" xlink:to="loc_-520000_21_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="exail_NetCashInflowOutflowOnTheAcquisitionDisposalOfSubsidiaries" xlink:href="exail-2022-12-31.xsd#exail_NetCashInflowOutflowOnTheAcquisitionDisposalOfSubsidiaries" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_5_1" xlink:to="exail_NetCashInflowOutflowOnTheAcquisitionDisposalOfSubsidiaries" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_ProceedsDisposalOfPropertyPlantAndEquipmentAndIntangibleAssets" xlink:href="exail-2022-12-31.xsd#exail_ProceedsDisposalOfPropertyPlantAndEquipmentAndIntangibleAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_5_1" xlink:to="exail_ProceedsDisposalOfPropertyPlantAndEquipmentAndIntangibleAssets" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_6_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:type="locator" />
    <link:loc xlink:label="loc_-520000_7_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_6_1" xlink:to="loc_-520000_7_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_9_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_6_1" xlink:to="loc_-520000_9_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_12_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInWorkingCapital" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_6_1" xlink:to="loc_-520000_12_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_1_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncomeTaxExpense" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_7_1" xlink:to="loc_-520000_1_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_AdjustmentsForExpenseForNetDebt" xlink:href="exail-2022-12-31.xsd#exail_AdjustmentsForExpenseForNetDebt" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_7_1" xlink:to="exail_AdjustmentsForExpenseForNetDebt" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_CashFlowFromOperatingActivitiesBeforeEliminationOfNetBorrowingCostsAndTaxes" xlink:href="exail-2022-12-31.xsd#exail_CashFlowFromOperatingActivitiesBeforeEliminationOfNetBorrowingCostsAndTaxes" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_7_1" xlink:to="exail_CashFlowFromOperatingActivitiesBeforeEliminationOfNetBorrowingCostsAndTaxes" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_10_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents" xlink:type="locator" />
    <link:loc xlink:label="loc_-520000_11_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsDiscontinuedOperations" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_10_1" xlink:to="loc_-520000_11_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="exail_CashFlowsFromUsedInContinuingActivities" xlink:href="exail-2022-12-31.xsd#exail_CashFlowsFromUsedInContinuingActivities" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="loc_-520000_10_1" xlink:to="exail_CashFlowsFromUsedInContinuingActivities" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_2_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CashFlowFromOperatingActivitiesBeforeEliminationOfNetBorrowingCostsAndTaxes" xlink:to="loc_-520000_2_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_3_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CashFlowFromOperatingActivitiesBeforeEliminationOfNetBorrowingCostsAndTaxes" xlink:to="loc_-520000_3_1" xlink:type="arc" weight="-1" />
    <link:loc xlink:label="loc_-520000_14_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherAdjustmentsForNoncashItems" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CashFlowFromOperatingActivitiesBeforeEliminationOfNetBorrowingCostsAndTaxes" xlink:to="loc_-520000_14_1" xlink:type="arc" weight="1" />
    <link:loc xlink:label="loc_-520000_18_1" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromContinuingOperations" xlink:type="locator" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CashFlowFromOperatingActivitiesBeforeEliminationOfNetBorrowingCostsAndTaxes" xlink:to="loc_-520000_18_1" xlink:type="arc" weight="1" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CashFlowsFromUsedInContinuingActivities" xlink:to="loc_-520000_4_1" xlink:type="arc" weight="1" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CashFlowsFromUsedInContinuingActivities" xlink:to="loc_-520000_5_1" xlink:type="arc" weight="1" />
    <link:calculationArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" order="1" xlink:from="exail_CashFlowsFromUsedInContinuingActivities" xlink:to="loc_-520000_6_1" xlink:type="arc" weight="1" />
  </link:calculationLink>
</link:linkbase>