<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:87969121-76bc-4772-80da-31d66bdd1a4d,g:fa34d1e9-b419-4757-8902-9f886359d31e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:arcroleRef arcroleURI="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd#wider-narrower"/>
  <link:roleRef roleURI="http://www.sanofi.com/role/tatdesvariationsdescapitauxpropres" xlink:type="simple" xlink:href="sny-2025-12-31.xsd#tatdesvariationsdescapitauxpropres"/>
  <link:definitionLink xlink:role="http://www.sanofi.com/role/tatdesvariationsdescapitauxpropres" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityAbstract_af7be74e-d730-4f4d-b1c9-4fd7f209a401" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityTable_d06d72a3-ebb5-4776-b1fd-adf06ca46ae7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_af7be74e-d730-4f4d-b1c9-4fd7f209a401" xlink:to="loc_ifrs-full_StatementOfChangesInEquityTable_d06d72a3-ebb5-4776-b1fd-adf06ca46ae7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComponentsOfEquityAxis_57cd32c2-149d-44e6-a2ae-b422b6484574" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComponentsOfEquityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_StatementOfChangesInEquityTable_d06d72a3-ebb5-4776-b1fd-adf06ca46ae7" xlink:to="loc_ifrs-full_ComponentsOfEquityAxis_57cd32c2-149d-44e6-a2ae-b422b6484574" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComponentsOfEquityDomain_af845524-fa46-4d36-a0e7-6a5b3f39280d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComponentsOfEquityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_ComponentsOfEquityAxis_57cd32c2-149d-44e6-a2ae-b422b6484574" xlink:to="loc_ifrs-full_ComponentsOfEquityDomain_af845524-fa46-4d36-a0e7-6a5b3f39280d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_af845524-fa46-4d36-a0e7-6a5b3f39280d" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapitalMember_56c60873-88a1-4cf5-9edf-5816043c84ee" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IssuedCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:to="loc_ifrs-full_IssuedCapitalMember_56c60873-88a1-4cf5-9edf-5816043c84ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdditionalPaidinCapitalMember_bacd09f8-2214-4319-bc01-cf14588a6cff" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdditionalPaidinCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:to="loc_ifrs-full_AdditionalPaidinCapitalMember_bacd09f8-2214-4319-bc01-cf14588a6cff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasurySharesMember_1730efc7-b555-40ec-bda4-902d81774355" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TreasurySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:to="loc_ifrs-full_TreasurySharesMember_1730efc7-b555-40ec-bda4-902d81774355" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarningsMember_fd7fc2b2-c324-4e4e-b34c-37b3ec4231d7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:to="loc_ifrs-full_RetainedEarningsMember_fd7fc2b2-c324-4e4e-b34c-37b3ec4231d7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfSharebasedPaymentsMember_7fc420e9-4c63-4723-9f2a-70f3137bf731" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReserveOfSharebasedPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:to="loc_ifrs-full_ReserveOfSharebasedPaymentsMember_7fc420e9-4c63-4723-9f2a-70f3137bf731" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AccumulatedOtherComprehensiveIncomeMember_3d68ce9a-c34c-4765-b45d-bf84e387e6ef" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_d675eaf3-42a4-4dfa-b170-b6d4db997fa5" xlink:to="loc_ifrs-full_AccumulatedOtherComprehensiveIncomeMember_3d68ce9a-c34c-4765-b45d-bf84e387e6ef" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterestsMember_5feaee6e-9df6-4c7e-99d9-317c25590928" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncontrollingInterestsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ComponentsOfEquityDomain_af845524-fa46-4d36-a0e7-6a5b3f39280d" xlink:to="loc_ifrs-full_NoncontrollingInterestsMember_5feaee6e-9df6-4c7e-99d9-317c25590928" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SignificantInvestmentsInSubsidiariesAxis_5402ce16-84a6-412e-921d-6cd98fd684b5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SignificantInvestmentsInSubsidiariesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_StatementOfChangesInEquityTable_d06d72a3-ebb5-4776-b1fd-adf06ca46ae7" xlink:to="loc_ifrs-full_SignificantInvestmentsInSubsidiariesAxis_5402ce16-84a6-412e-921d-6cd98fd684b5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SignificantInvestmentsInSubsidiariesDomain_a1eca042-f6df-41e2-9391-fc42bfc7a619" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SignificantInvestmentsInSubsidiariesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_SignificantInvestmentsInSubsidiariesAxis_5402ce16-84a6-412e-921d-6cd98fd684b5" xlink:to="loc_ifrs-full_SignificantInvestmentsInSubsidiariesDomain_a1eca042-f6df-41e2-9391-fc42bfc7a619" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_EuroapiMember_e13d3e20-25a0-44be-8e57-fc7ef467dc52" xlink:href="sny-2025-12-31.xsd#sny_EuroapiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_SignificantInvestmentsInSubsidiariesDomain_a1eca042-f6df-41e2-9391-fc42bfc7a619" xlink:to="loc_sny_EuroapiMember_e13d3e20-25a0-44be-8e57-fc7ef467dc52" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityLineItems_117a0cc8-d62c-4b3d-8648-eaa199e81551" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityLineItems"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_af7be74e-d730-4f4d-b1c9-4fd7f209a401" xlink:to="loc_ifrs-full_StatementOfChangesInEquityLineItems_117a0cc8-d62c-4b3d-8648-eaa199e81551" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_ce81ea69-490b-4767-938f-1bb28beb28a6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_117a0cc8-d62c-4b3d-8648-eaa199e81551" xlink:to="loc_ifrs-full_Equity_ce81ea69-490b-4767-938f-1bb28beb28a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ChangesInEquityAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_117a0cc8-d62c-4b3d-8648-eaa199e81551" xlink:to="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_c4c54b6d-1411-449c-a6e1-12d42256206e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_c4c54b6d-1411-449c-a6e1-12d42256206e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_86804655-3d91-4d96-ae61-da0b92012042" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_ProfitLoss_86804655-3d91-4d96-ae61-da0b92012042" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_357a04fe-cd76-4e3b-b5d6-3419730f40ac" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_ComprehensiveIncome_357a04fe-cd76-4e3b-b5d6-3419730f40ac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent_c3b6dcaf-ea26-461a-8279-81aaefbc3fe1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_DividendsRecognisedAsDistributionsToOwnersOfParent_c3b6dcaf-ea26-461a-8279-81aaefbc3fe1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsRecognisedAsDistributionsToNoncontrollingInterests_6c67eb54-a163-498c-826d-976b1ee7b822" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsRecognisedAsDistributionsToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_DividendsRecognisedAsDistributionsToNoncontrollingInterests_6c67eb54-a163-498c-826d-976b1ee7b822" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidOrdinarySharesPerShare_b3d8a6e1-43db-4e8d-aecd-2ad2a3d72940" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsPaidOrdinarySharesPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_DividendsPaidOrdinarySharesPerShare_b3d8a6e1-43db-4e8d-aecd-2ad2a3d72940" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WeightedAverageSharePrice2019_43da63b9-b53c-44d6-bd22-04310bdc87ca" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_WeightedAverageSharePrice2019"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_WeightedAverageSharePrice2019_43da63b9-b53c-44d6-bd22-04310bdc87ca" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfTreasuryShares_1b3e2a89-d778-4b5c-9864-e111931417f0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfTreasuryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_PurchaseOfTreasuryShares_1b3e2a89-d778-4b5c-9864-e111931417f0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReductionOfIssuedCapital_94b2744f-cc08-4aff-b3e7-706bb2a73f08" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReductionOfIssuedCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_ReductionOfIssuedCapital_94b2744f-cc08-4aff-b3e7-706bb2a73f08" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_TaxeSurAnnulationDactions_91f7d258-329e-4d23-afbf-defdfb7909be" xlink:href="sny-2025-12-31.xsd#sny_TaxeSurAnnulationDactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_sny_TaxeSurAnnulationDactions_91f7d258-329e-4d23-afbf-defdfb7909be" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughExerciseOfOptions_05e205b5-bc47-453d-8bb8-8bea5c32a1d1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughExerciseOfOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughExerciseOfOptions_05e205b5-bc47-453d-8bb8-8bea5c32a1d1" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEmissionDactionsGratuitesEtAttributionDefinitiveDactionsGratuitesExistantesCapitauxPropres_b6183732-004f-43d8-b558-9f9f9b67f2c1" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEmissionDactionsGratuitesEtAttributionDefinitiveDactionsGratuitesExistantesCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEmissionDactionsGratuitesEtAttributionDefinitiveDactionsGratuitesExistantesCapitauxPropres_b6183732-004f-43d8-b558-9f9f9b67f2c1" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsAugmentationDeCapitalReserveesAuxSalariesCapitauxPropres_e957f81b-f713-45c7-842f-fa15cbb460de" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsAugmentationDeCapitalReserveesAuxSalariesCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsAugmentationDeCapitalReserveesAuxSalariesCapitauxPropres_e957f81b-f713-45c7-842f-fa15cbb460de" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsValeurDesServicesObtenusDesSalariesCapitauxPropres_f565601b-0bc9-4f08-a4df-4cb0d1b80159" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsValeurDesServicesObtenusDesSalariesCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsValeurDesServicesObtenusDesSalariesCapitauxPropres_f565601b-0bc9-4f08-a4df-4cb0d1b80159" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEffetDimpotsLieALaLeveeDoptionsCapitauxPropres_cfee098c-9a0f-4087-9037-b842bf0ab45a" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEffetDimpotsLieALaLeveeDoptionsCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEffetDimpotsLieALaLeveeDoptionsCapitauxPropres_cfee098c-9a0f-4087-9037-b842bf0ab45a" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDautresVariationsLieesALemissionDactionsGratuitesCapitauxPropres_29b9d7bf-7812-4fee-b371-039603d2d7dc" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDautresVariationsLieesALemissionDactionsGratuitesCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDautresVariationsLieesALemissionDactionsGratuitesCapitauxPropres_29b9d7bf-7812-4fee-b371-039603d2d7dc" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl_2881bb8f-8327-431b-beba-569063833d9c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl_2881bb8f-8327-431b-beba-569063833d9c" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDautreVariationDesInteretsNonControlantsCapitauxPropres_f2f25e37-53e1-4bc4-b971-6a1b54866c26" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDautreVariationDesInteretsNonControlantsCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDautreVariationDesInteretsNonControlantsCapitauxPropres_f2f25e37-53e1-4bc4-b971-6a1b54866c26" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_19990030-90ed-4b63-bbad-b1f34e1e3987" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ChangesInEquityAbstract_6013da72-d2a1-4b84-b977-a32bf3990804" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_19990030-90ed-4b63-bbad-b1f34e1e3987" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_5c639c15-0bf1-44ed-953c-981e1fea4ae9" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.sanofi.com/role/tatdesvariationsdescapitauxpropresDetails" xlink:type="simple" xlink:href="sny-2025-12-31.xsd#tatdesvariationsdescapitauxpropresDetails"/>
  <link:definitionLink xlink:role="http://www.sanofi.com/role/tatdesvariationsdescapitauxpropresDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityAbstract_b0505388-75be-4f88-b193-771bbf657f94" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityTable_a65b30bc-ab17-4e35-b367-e892d5fd1b9e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_b0505388-75be-4f88-b193-771bbf657f94" xlink:to="loc_ifrs-full_StatementOfChangesInEquityTable_a65b30bc-ab17-4e35-b367-e892d5fd1b9e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityLineItems_a55d1d13-be62-4fe1-996f-78e9925efaf1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityLineItems"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_b0505388-75be-4f88-b193-771bbf657f94" xlink:to="loc_ifrs-full_StatementOfChangesInEquityLineItems_a55d1d13-be62-4fe1-996f-78e9925efaf1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.sanofi.com/role/tatdesfluxdetrsoreriemthodeindirecteDetails" xlink:type="simple" xlink:href="sny-2025-12-31.xsd#tatdesfluxdetrsoreriemthodeindirecteDetails"/>
  <link:definitionLink xlink:role="http://www.sanofi.com/role/tatdesfluxdetrsoreriemthodeindirecteDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfCashFlowsAbstract_ce15ee69-cad0-4ec8-b7af-5ddd5d33c376" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable_6fbef51b-8c91-4674-b6f8-1e67d910846c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ifrs-full_StatementOfCashFlowsAbstract_ce15ee69-cad0-4ec8-b7af-5ddd5d33c376" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable_6fbef51b-8c91-4674-b6f8-1e67d910846c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SignificantInvestmentsInSubsidiariesAxis_71c22ab2-cb46-4a81-be56-837401a79cec" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SignificantInvestmentsInSubsidiariesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable_6fbef51b-8c91-4674-b6f8-1e67d910846c" xlink:to="loc_ifrs-full_SignificantInvestmentsInSubsidiariesAxis_71c22ab2-cb46-4a81-be56-837401a79cec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SignificantInvestmentsInSubsidiariesDomain_7a404d4f-1d8d-43e1-9a76-8d60d9670f4f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SignificantInvestmentsInSubsidiariesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_SignificantInvestmentsInSubsidiariesAxis_71c22ab2-cb46-4a81-be56-837401a79cec" xlink:to="loc_ifrs-full_SignificantInvestmentsInSubsidiariesDomain_7a404d4f-1d8d-43e1-9a76-8d60d9670f4f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_EuroapiMember_db454747-526a-4582-951b-0faac36337d0" xlink:href="sny-2025-12-31.xsd#sny_EuroapiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_SignificantInvestmentsInSubsidiariesDomain_7a404d4f-1d8d-43e1-9a76-8d60d9670f4f" xlink:to="loc_sny_EuroapiMember_db454747-526a-4582-951b-0faac36337d0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BorrowingsByNameAxis_99319f9d-abf7-445a-8d05-8f59519267f3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BorrowingsByNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable_6fbef51b-8c91-4674-b6f8-1e67d910846c" xlink:to="loc_ifrs-full_BorrowingsByNameAxis_99319f9d-abf7-445a-8d05-8f59519267f3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BorrowingsByNameDomain_e0e58b1e-c36d-4729-a575-60f7ee456e9d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BorrowingsByNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_BorrowingsByNameAxis_99319f9d-abf7-445a-8d05-8f59519267f3" xlink:to="loc_ifrs-full_BorrowingsByNameDomain_e0e58b1e-c36d-4729-a575-60f7ee456e9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProgrammeDeCommercialPaperAuxEtatsUnisMember_b84203d3-f7a6-41a4-a885-7f31d7b55313" xlink:href="sny-2025-12-31.xsd#sny_ProgrammeDeCommercialPaperAuxEtatsUnisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_BorrowingsByNameDomain_e0e58b1e-c36d-4729-a575-60f7ee456e9d" xlink:to="loc_sny_ProgrammeDeCommercialPaperAuxEtatsUnisMember_b84203d3-f7a6-41a4-a885-7f31d7b55313" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProgrammeDePapierCommercialAuxEtatsUnis_f1ff3199-1344-4074-abe4-93e1e33441f1" xlink:href="sny-2025-12-31.xsd#sny_ProgrammeDePapierCommercialAuxEtatsUnis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_BorrowingsByNameDomain_e0e58b1e-c36d-4729-a575-60f7ee456e9d" xlink:to="loc_sny_ProgrammeDePapierCommercialAuxEtatsUnis_f1ff3199-1344-4074-abe4-93e1e33441f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProductsAndServicesAxis_713d37e5-1d27-4a9c-80b0-12110d3b7a8a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProductsAndServicesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable_6fbef51b-8c91-4674-b6f8-1e67d910846c" xlink:to="loc_ifrs-full_ProductsAndServicesAxis_713d37e5-1d27-4a9c-80b0-12110d3b7a8a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProductsAndServicesDomain_1bc507d5-7529-4cdf-8f89-20285cc9569e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_ProductsAndServicesAxis_713d37e5-1d27-4a9c-80b0-12110d3b7a8a" xlink:to="loc_ifrs-full_ProductsAndServicesDomain_1bc507d5-7529-4cdf-8f89-20285cc9569e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_EnjaymoGlobalRights_67d9f642-c74e-422d-9a50-687a554f8923" xlink:href="sny-2025-12-31.xsd#sny_EnjaymoGlobalRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_ProductsAndServicesDomain_1bc507d5-7529-4cdf-8f89-20285cc9569e" xlink:to="loc_sny_EnjaymoGlobalRights_67d9f642-c74e-422d-9a50-687a554f8923" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BusinessCombinationsAxis_019bd175-5076-7d0f-97a5-dbd9aa4952ca" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BusinessCombinationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable_6fbef51b-8c91-4674-b6f8-1e67d910846c" xlink:to="loc_ifrs-full_BusinessCombinationsAxis_019bd175-5076-7d0f-97a5-dbd9aa4952ca" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BusinessCombinationsDomain_019bd175-5076-7329-bbeb-4825b17ff238" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BusinessCombinationsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_BusinessCombinationsAxis_019bd175-5076-7d0f-97a5-dbd9aa4952ca" xlink:to="loc_ifrs-full_BusinessCombinationsDomain_019bd175-5076-7329-bbeb-4825b17ff238" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_OpellaBusiness_019bd176-5ff2-77e6-a8cf-da4f9eb43a7c" xlink:href="sny-2025-12-31.xsd#sny_OpellaBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_BusinessCombinationsDomain_019bd175-5076-7329-bbeb-4825b17ff238" xlink:to="loc_sny_OpellaBusiness_019bd176-5ff2-77e6-a8cf-da4f9eb43a7c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfCashFlowsAbstract_ce15ee69-cad0-4ec8-b7af-5ddd5d33c376" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_ea7580fe-3644-415d-932b-74a8908421e0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_ea7580fe-3644-415d-932b-74a8908421e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_d0cffdd0-2c5f-41f5-8522-42095ce16be2" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_d0cffdd0-2c5f-41f5-8522-42095ce16be2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_f69441e0-6fb1-420b-bc3e-1c7bb4fb56df" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_f69441e0-6fb1-420b-bc3e-1c7bb4fb56df" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_DividendesRecusDesSocietesNonConsolideesClassesDansLesActivitesOperationnelles_0e256b4a-cb5d-4df5-add8-06e6b67dedfa" xlink:href="sny-2025-12-31.xsd#sny_DividendesRecusDesSocietesNonConsolideesClassesDansLesActivitesOperationnelles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_sny_DividendesRecusDesSocietesNonConsolideesClassesDansLesActivitesOperationnelles_0e256b4a-cb5d-4df5-add8-06e6b67dedfa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_5523421d-cbd5-4c9b-aebe-394089f67587" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_5523421d-cbd5-4c9b-aebe-394089f67587" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers_4746d6f9-387b-4e3d-a28d-aa9620b99a7a" xlink:href="sny-2025-12-31.xsd#sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers_4746d6f9-387b-4e3d-a28d-aa9620b99a7a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_26c663d4-d002-476d-b6ed-ae8af4578058" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_26c663d4-d002-476d-b6ed-ae8af4578058" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_FluxDeTresorerieProvenantDeUtilisesDansLaugmentationDiminutionDesEmpruntsCourantsEtDautresInstrumentsFinanciers_b4d1793d-cc80-42c6-92c6-de6d5802f3af" xlink:href="sny-2025-12-31.xsd#sny_FluxDeTresorerieProvenantDeUtilisesDansLaugmentationDiminutionDesEmpruntsCourantsEtDautresInstrumentsFinanciers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_sny_FluxDeTresorerieProvenantDeUtilisesDansLaugmentationDiminutionDesEmpruntsCourantsEtDautresInstrumentsFinanciers_b4d1793d-cc80-42c6-92c6-de6d5802f3af" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDeferredTaxExpense_019c2770-e343-7753-8771-c00c9e6454df" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDeferredTaxExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_AdjustmentsForDeferredTaxExpense_019c2770-e343-7753-8771-c00c9e6454df" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_019c2775-336e-788b-9f0d-372583456e2f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_019c2775-336e-788b-9f0d-372583456e2f" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AdjustmentsForNonCurrentFinancialAssetsAndDeferredTaxExpense_019c278d-3875-7309-b6d1-56c700c5cedb" xlink:href="sny-2025-12-31.xsd#sny_AdjustmentsForNonCurrentFinancialAssetsAndDeferredTaxExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_sny_AdjustmentsForNonCurrentFinancialAssetsAndDeferredTaxExpense_019c278d-3875-7309-b6d1-56c700c5cedb" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_019c4715-befc-707b-a2e2-77da25556028" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesLineItems_5b7ba967-2797-4dcf-9eb6-8430bc78a7fb" xlink:to="loc_ifrs-full_CashAndCashEquivalents_019c4715-befc-707b-a2e2-77da25556028" xlink:type="arc" order="12"/>
  </link:definitionLink>
  <link:roleRef roleURI="https://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="simple" xlink:href="https://www.esma.europa.eu/taxonomy/2024-03-27/esef_cor.xsd#esef_role-999999"/>
  <link:definitionLink xlink:role="https://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:href="https://www.esma.europa.eu/taxonomy/2024-03-27/esef_cor.xsd#esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_f1e56070-0694-4323-b24a-85fcdf45f119NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_f1e56070-0694-4323-b24a-85fcdf45f119NotDimensionallyQualified" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_1dc29677-628e-46c4-91b5-138ea8f19334NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RightofuseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RightofuseAssets_1dc29677-628e-46c4-91b5-138ea8f19334NotDimensionallyQualified" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_3356a6bb-ca2a-4e90-beaf-b85b6340a56aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Goodwill_3356a6bb-ca2a-4e90-beaf-b85b6340a56aNotDimensionallyQualified" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_be608864-469f-444d-aad8-076ed01615f5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_be608864-469f-444d-aad8-076ed01615f5NotDimensionallyQualified" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_44848118-0a0f-4764-9a05-155f36a7ad94NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InvestmentAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_44848118-0a0f-4764-9a05-155f36a7ad94NotDimensionallyQualified" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_5bd35527-e855-4a93-9bab-23b91845631bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_5bd35527-e855-4a93-9bab-23b91845631bNotDimensionallyQualified" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsNoncurrent_64d533c2-567f-4176-a13c-924fe90f1d57NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxAssetsNoncurrent_64d533c2-567f-4176-a13c-924fe90f1d57NotDimensionallyQualified" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_8bc4a917-55ff-4901-9e0b-ec71d7cf654fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DeferredTaxAssets_8bc4a917-55ff-4901-9e0b-ec71d7cf654fNotDimensionallyQualified" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_d2d9480e-6243-4e31-99ea-3393663d626eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentAssets_d2d9480e-6243-4e31-99ea-3393663d626eNotDimensionallyQualified" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_30a44cce-d500-4802-91cf-47323f79fa2eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Inventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Inventories_30a44cce-d500-4802-91cf-47323f79fa2eNotDimensionallyQualified" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTradeReceivables_bdc305d2-61da-4557-9022-e84675d36b72NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTradeReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTradeReceivables_bdc305d2-61da-4557-9022-e84675d36b72NotDimensionallyQualified" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentAssets_91cad44d-6b6a-4a5f-915e-d62f6a94c5abNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCurrentAssets_91cad44d-6b6a-4a5f-915e-d62f6a94c5abNotDimensionallyQualified" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_da89599f-0094-44cd-ad96-faab4964e022NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_da89599f-0094-44cd-ad96-faab4964e022NotDimensionallyQualified" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_a2bae4ad-709e-462c-b057-3f5103414e14NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashAndCashEquivalents_a2bae4ad-709e-462c-b057-3f5103414e14NotDimensionallyQualified" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_878848f7-172d-4bac-87b9-753df249627aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentAssets_878848f7-172d-4bac-87b9-753df249627aNotDimensionallyQualified" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_11f709f9-7940-4c8f-9838-aad0f6d853ecNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_11f709f9-7940-4c8f-9838-aad0f6d853ecNotDimensionallyQualified" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_3f1e89cc-1691-4c97-a0a4-59a1744e52e5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Assets_3f1e89cc-1691-4c97-a0a4-59a1744e52e5NotDimensionallyQualified" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_d4606c47-f2c9-4215-90c7-3f8a095bec6bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_d4606c47-f2c9-4215-90c7-3f8a095bec6bNotDimensionallyQualified" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_bf1b68bf-fae0-4bfb-b811-e41bac6a2299NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncontrollingInterests_bf1b68bf-fae0-4bfb-b811-e41bac6a2299NotDimensionallyQualified" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_e732a40d-ebbe-4da8-9c59-e2be017d8068NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Equity_e732a40d-ebbe-4da8-9c59-e2be017d8068NotDimensionallyQualified" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LongtermBorrowings_62a66470-a197-47d1-bc77-42638d640b11NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LongtermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LongtermBorrowings_62a66470-a197-47d1-bc77-42638d640b11NotDimensionallyQualified" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLeaseLiabilities_78b4d6aa-f2ec-42e7-85c4-dec0d183601aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentLeaseLiabilities_78b4d6aa-f2ec-42e7-85c4-dec0d183601aNotDimensionallyQualified" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_PassifsNonCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_c2cc834d-2c38-4dbc-98cc-0a05e314bc50NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_PassifsNonCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_PassifsNonCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_c2cc834d-2c38-4dbc-98cc-0a05e314bc50NotDimensionallyQualified" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProvisionsEtAutresPassifsNonCourants_2cf71554-24ab-4bf2-b6c9-6eba90f58d63NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_ProvisionsEtAutresPassifsNonCourants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_ProvisionsEtAutresPassifsNonCourants_2cf71554-24ab-4bf2-b6c9-6eba90f58d63NotDimensionallyQualified" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesNoncurrent_de79d49b-720f-48bf-9c46-392419248ff5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesNoncurrent_de79d49b-720f-48bf-9c46-392419248ff5NotDimensionallyQualified" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_b8c19d5d-f25f-43a6-96c0-9eab7834b579NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_b8c19d5d-f25f-43a6-96c0-9eab7834b579NotDimensionallyQualified" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_6c66d1ff-3caa-4a0e-888d-37343b9386ecNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentLiabilities_6c66d1ff-3caa-4a0e-888d-37343b9386ecNotDimensionallyQualified" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_370e8867-9d5c-4875-b013-7d436c7975b7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayablesToTradeSuppliers_370e8867-9d5c-4875-b013-7d436c7975b7NotDimensionallyQualified" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_PassifsCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_d06179a8-e553-4d19-a32b-c4a9733886e0NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_PassifsCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_PassifsCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_d06179a8-e553-4d19-a32b-c4a9733886e0NotDimensionallyQualified" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProvisionsEtAutresPassifsCourants_fb895e4e-18b3-4722-877c-869be82835b8NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_ProvisionsEtAutresPassifsCourants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_ProvisionsEtAutresPassifsCourants_fb895e4e-18b3-4722-877c-869be82835b8NotDimensionallyQualified" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_25dcf135-aefe-4bd5-9a78-eee1f551c11bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxLiabilitiesCurrent_25dcf135-aefe-4bd5-9a78-eee1f551c11bNotDimensionallyQualified" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLeaseLiabilities_0a56affe-4301-4c83-97ad-b11b6de21470NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentLeaseLiabilities_0a56affe-4301-4c83-97ad-b11b6de21470NotDimensionallyQualified" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentBorrowingsAndCurrentPortionOfNoncurrentBorrowings_6bf94e0d-1cf6-4cb2-9e77-affbd25b387aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentBorrowingsAndCurrentPortionOfNoncurrentBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentBorrowingsAndCurrentPortionOfNoncurrentBorrowings_6bf94e0d-1cf6-4cb2-9e77-affbd25b387aNotDimensionallyQualified" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_026e9e38-5cf1-49b5-a3a7-65fd8b37c3c9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentLiabilities_026e9e38-5cf1-49b5-a3a7-65fd8b37c3c9NotDimensionallyQualified" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale_47d17b0b-726a-4bae-ad4c-0faa32e4122fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale_47d17b0b-726a-4bae-ad4c-0faa32e4122fNotDimensionallyQualified" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_4e0edac2-895e-42b6-8335-06589e4297c8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAndLiabilities_4e0edac2-895e-42b6-8335-06589e4297c8NotDimensionallyQualified" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromSaleOfGoods_73d62475-652d-4d2a-80dd-91ca5e8fc1e6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RevenueFromSaleOfGoods"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RevenueFromSaleOfGoods_73d62475-652d-4d2a-80dd-91ca5e8fc1e6NotDimensionallyQualified" xlink:type="arc" order="36"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherRevenue_e6c98010-e1e1-46f0-9b32-5562421f8151NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherRevenue_e6c98010-e1e1-46f0-9b32-5562421f8151NotDimensionallyQualified" xlink:type="arc" order="37"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales_2387f2a4-f7d4-4f87-aa9c-b460107d63ceNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CostOfSales"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CostOfSales_2387f2a4-f7d4-4f87-aa9c-b460107d63ceNotDimensionallyQualified" xlink:type="arc" order="38"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GrossProfit_50d08eb7-f341-4e21-a6db-143e3d50a2e3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GrossProfit_50d08eb7-f341-4e21-a6db-143e3d50a2e3NotDimensionallyQualified" xlink:type="arc" order="39"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_86e1d3b2-a5c6-404a-9bd7-3fd015865584NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_86e1d3b2-a5c6-404a-9bd7-3fd015865584NotDimensionallyQualified" xlink:type="arc" order="40"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_3de18ed2-96b5-4f50-9e75-4d7dc23f0c93NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_3de18ed2-96b5-4f50-9e75-4d7dc23f0c93NotDimensionallyQualified" xlink:type="arc" order="41"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingIncome_2f6fe53e-6b97-4d44-a676-235fa6561069NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingIncome_2f6fe53e-6b97-4d44-a676-235fa6561069NotDimensionallyQualified" xlink:type="arc" order="42"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MiscellaneousOtherOperatingExpense_0db68bc2-88ca-4225-b971-fbd2847ad6c2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_MiscellaneousOtherOperatingExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_MiscellaneousOtherOperatingExpense_0db68bc2-88ca-4225-b971-fbd2847ad6c2NotDimensionallyQualified" xlink:type="arc" order="43"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AmortisationIntangibleAssetsOtherThanGoodwill_5e7005b3-e932-4015-820a-68ca1b880c88NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AmortisationIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AmortisationIntangibleAssetsOtherThanGoodwill_5e7005b3-e932-4015-820a-68ca1b880c88NotDimensionallyQualified" xlink:type="arc" order="44"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLossIntangibleAssetsOtherThanGoodwill_4e288d92-3231-4006-a3e4-11d9d53c9355NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ImpairmentLossRecognisedInProfitOrLossIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLossIntangibleAssetsOtherThanGoodwill_4e288d92-3231-4006-a3e4-11d9d53c9355NotDimensionallyQualified" xlink:type="arc" order="45"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInContingentConsiderationAssetLiability_2210d722-339d-44c0-95d3-2ee37bb66e4cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInContingentConsiderationAssetLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncreaseDecreaseInContingentConsiderationAssetLiability_2210d722-339d-44c0-95d3-2ee37bb66e4cNotDimensionallyQualified" xlink:type="arc" order="46"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExpenseOfRestructuringActivities_734f2ad7-650b-4d1f-a4bd-72d71061a810NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ExpenseOfRestructuringActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ExpenseOfRestructuringActivities_734f2ad7-650b-4d1f-a4bd-72d71061a810NotDimensionallyQualified" xlink:type="arc" order="47"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AutresProfitsPertesLitiges_647bc76b-f10f-43c4-900f-9ffc5bef0f55NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_AutresProfitsPertesLitiges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_AutresProfitsPertesLitiges_647bc76b-f10f-43c4-900f-9ffc5bef0f55NotDimensionallyQualified" xlink:type="arc" order="48"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_76c9c139-fe2a-490d-b220-18d3e1f8ad08NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_76c9c139-fe2a-490d-b220-18d3e1f8ad08NotDimensionallyQualified" xlink:type="arc" order="49"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_7eb94f42-8377-41a9-ac3a-2923185c9461NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceCosts_7eb94f42-8377-41a9-ac3a-2923185c9461NotDimensionallyQualified" xlink:type="arc" order="50"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_1979c26d-de91-45d7-ae3f-ed21c007d990NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceIncome_1979c26d-de91-45d7-ae3f-ed21c007d990NotDimensionallyQualified" xlink:type="arc" order="51"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ResultatAvantImpotsEtSocietesMisesEnEquivalence_e22d5288-4883-451a-9d14-78d4c067daa3NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_ResultatAvantImpotsEtSocietesMisesEnEquivalence"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_ResultatAvantImpotsEtSocietesMisesEnEquivalence_e22d5288-4883-451a-9d14-78d4c067daa3NotDimensionallyQualified" xlink:type="arc" order="52"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_5aacd8bd-759c-40ab-9e7e-ccbace27fca4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_5aacd8bd-759c-40ab-9e7e-ccbace27fca4NotDimensionallyQualified" xlink:type="arc" order="53"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfProfitLossOfAssociatesAccountedForUsingEquityMethod_e1c552b3-e13c-4cdc-8adf-61c8afce95b4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ShareOfProfitLossOfAssociatesAccountedForUsingEquityMethod_e1c552b3-e13c-4cdc-8adf-61c8afce95b4NotDimensionallyQualified" xlink:type="arc" order="54"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations_dd444228-c8e0-40d4-8ed6-8bb4016cc1bbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossFromContinuingOperations_dd444228-c8e0-40d4-8ed6-8bb4016cc1bbNotDimensionallyQualified" xlink:type="arc" order="55"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_96a4c062-7ae9-4f8a-b255-118fb7b5ffa8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLoss_96a4c062-7ae9-4f8a-b255-118fb7b5ffa8NotDimensionallyQualified" xlink:type="arc" order="56"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_55aae4ce-cb9d-4f56-b77d-4d3447a9509aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_55aae4ce-cb9d-4f56-b77d-4d3447a9509aNotDimensionallyQualified" xlink:type="arc" order="57"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_bfa1949e-ee98-4c1e-a097-0de39e6f9e39NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_bfa1949e-ee98-4c1e-a097-0de39e6f9e39NotDimensionallyQualified" xlink:type="arc" order="58"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_WeightedAverageShares_1e25fc23-2439-4fcf-8388-008076f3341cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_WeightedAverageShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_WeightedAverageShares_1e25fc23-2439-4fcf-8388-008076f3341cNotDimensionallyQualified" xlink:type="arc" order="59"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustedWeightedAverageShares_64279ce0-2d4e-4839-a07d-4bdcd0e727dcNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustedWeightedAverageShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustedWeightedAverageShares_64279ce0-2d4e-4839-a07d-4bdcd0e727dcNotDimensionallyQualified" xlink:type="arc" order="60"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BasicEarningsLossPerShareFromContinuingOperations_e0c7853d-ae3b-4b52-a1fe-de64b9a0fc21NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BasicEarningsLossPerShareFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_BasicEarningsLossPerShareFromContinuingOperations_e0c7853d-ae3b-4b52-a1fe-de64b9a0fc21NotDimensionallyQualified" xlink:type="arc" order="61"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BasicEarningsLossPerShareFromDiscontinuedOperations_14ed0f6e-0274-40f2-b2c8-bb15493b518aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BasicEarningsLossPerShareFromDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_BasicEarningsLossPerShareFromDiscontinuedOperations_14ed0f6e-0274-40f2-b2c8-bb15493b518aNotDimensionallyQualified" xlink:type="arc" order="62"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BasicEarningsLossPerShare_4b2a7f7f-4a4f-40a5-b13f-7838b0845a46NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BasicEarningsLossPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_BasicEarningsLossPerShare_4b2a7f7f-4a4f-40a5-b13f-7838b0845a46NotDimensionallyQualified" xlink:type="arc" order="63"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DilutedEarningsLossPerShareFromContinuingOperations_b3f597c7-5641-4299-b83e-3a9d3fe606d3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DilutedEarningsLossPerShareFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DilutedEarningsLossPerShareFromContinuingOperations_b3f597c7-5641-4299-b83e-3a9d3fe606d3NotDimensionallyQualified" xlink:type="arc" order="64"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DilutedEarningsLossPerShareFromDiscontinuedOperations_a03686ce-e90e-41a6-9884-0e0a808026ffNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DilutedEarningsLossPerShareFromDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DilutedEarningsLossPerShareFromDiscontinuedOperations_a03686ce-e90e-41a6-9884-0e0a808026ffNotDimensionallyQualified" xlink:type="arc" order="65"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DilutedEarningsLossPerShare_cb882ca6-e448-43af-8319-ae8ca428df26NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DilutedEarningsLossPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DilutedEarningsLossPerShare_cb882ca6-e448-43af-8319-ae8ca428df26NotDimensionallyQualified" xlink:type="arc" order="66"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_bddcde8c-a316-42ed-8af9-3c5198a5c18dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossFromDiscontinuedOperations_bddcde8c-a316-42ed-8af9-3c5198a5c18dNotDimensionallyQualified" xlink:type="arc" order="67"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ActuarialGainsLossesArisingFromChangesInFinancialAssumptionsNetDefinedBenefitLiabilityAsset_8c35e4a8-07f1-470b-8d12-63bcb256710eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ActuarialGainsLossesArisingFromChangesInFinancialAssumptionsNetDefinedBenefitLiabilityAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ActuarialGainsLossesArisingFromChangesInFinancialAssumptionsNetDefinedBenefitLiabilityAsset_8c35e4a8-07f1-470b-8d12-63bcb256710eNotDimensionallyQualified" xlink:type="arc" order="68"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInOtherComprehensiveIncomeFairValueMeasurementEntitysOwnEquityInstruments_f881643b-5aaa-4c7f-8e92-7476d7aa1698NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesRecognisedInOtherComprehensiveIncomeFairValueMeasurementEntitysOwnEquityInstruments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesRecognisedInOtherComprehensiveIncomeFairValueMeasurementEntitysOwnEquityInstruments_f881643b-5aaa-4c7f-8e92-7476d7aa1698NotDimensionallyQualified" xlink:type="arc" order="69"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLoss_3b80123e-fb20-4f9f-8b13-dede0a2142eaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLoss_3b80123e-fb20-4f9f-8b13-dede0a2142eaNotDimensionallyQualified" xlink:type="arc" order="70"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_f162c1b4-d57e-462a-9472-f1cdc787fbd3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_f162c1b4-d57e-462a-9472-f1cdc787fbd3NotDimensionallyQualified" xlink:type="arc" order="71"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProfitsPertesSurInstrumentsDeDetteEnActifsFinanciersAvantImpot_edd69680-77bd-4a27-95c3-31c4ebd6afe6NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_ProfitsPertesSurInstrumentsDeDetteEnActifsFinanciersAvantImpot"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_ProfitsPertesSurInstrumentsDeDetteEnActifsFinanciersAvantImpot_edd69680-77bd-4a27-95c3-31c4ebd6afe6NotDimensionallyQualified" xlink:type="arc" order="72"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_142d5f40-5349-4c55-95f1-14316a39aa64NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_142d5f40-5349-4c55-95f1-14316a39aa64NotDimensionallyQualified" xlink:type="arc" order="73"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_9b8858b0-ba98-45cd-a11f-f6959fd5a9c4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_9b8858b0-ba98-45cd-a11f-f6959fd5a9c4NotDimensionallyQualified" xlink:type="arc" order="74"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLoss_7f8086e0-94b8-4519-83e2-62353f656203NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxRelatingToComponentsOfOtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLoss_7f8086e0-94b8-4519-83e2-62353f656203NotDimensionallyQualified" xlink:type="arc" order="75"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_aee9a829-3203-4dfb-9fdf-17c74f24ccdbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_aee9a829-3203-4dfb-9fdf-17c74f24ccdbNotDimensionallyQualified" xlink:type="arc" order="76"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_OtherComprehensiveIncomeFromContinuingOperations_c2844a74-e206-4255-a2df-4e28830199caNotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_OtherComprehensiveIncomeFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_OtherComprehensiveIncomeFromContinuingOperations_c2844a74-e206-4255-a2df-4e28830199caNotDimensionallyQualified" xlink:type="arc" order="77"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_OtherComprehensiveIncomeFromDiscontinuedOperations_16e4f9ed-547b-4b9a-abf7-46c7b4a081e1NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_OtherComprehensiveIncomeFromDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_OtherComprehensiveIncomeFromDiscontinuedOperations_16e4f9ed-547b-4b9a-abf7-46c7b4a081e1NotDimensionallyQualified" xlink:type="arc" order="78"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_01267e25-7bff-4140-b136-98709274b3a2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncome_01267e25-7bff-4140-b136-98709274b3a2NotDimensionallyQualified" xlink:type="arc" order="79"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_be3b7169-f404-4dfc-a5a5-24f93aecb5d2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_be3b7169-f404-4dfc-a5a5-24f93aecb5d2NotDimensionallyQualified" xlink:type="arc" order="80"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocietePoursuiviesMere_921759d3-17b2-4a53-976a-f5aec7637551NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocietePoursuiviesMere"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocietePoursuiviesMere_921759d3-17b2-4a53-976a-f5aec7637551NotDimensionallyQualified" xlink:type="arc" order="81"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocieteAbandonnees_0f5adb4c-78b1-4588-adf3-b93565e4d0deNotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocieteAbandonnees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocieteAbandonnees_0f5adb4c-78b1-4588-adf3-b93565e4d0deNotDimensionallyQualified" xlink:type="arc" order="82"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_f8ab489c-5e72-451f-aa51-d0b2567eee72NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_f8ab489c-5e72-451f-aa51-d0b2567eee72NotDimensionallyQualified" xlink:type="arc" order="83"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOrdinaryEquityHoldersOfParentEntity_5ceaa140-cade-44c4-ab7b-e26d0fb392bfNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossAttributableToOrdinaryEquityHoldersOfParentEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToOrdinaryEquityHoldersOfParentEntity_5ceaa140-cade-44c4-ab7b-e26d0fb392bfNotDimensionallyQualified" xlink:type="arc" order="84"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourPertesGainsSurCessionDentreprise_8810ae26-a15a-4ccd-ae81-ce8f0a39bc70NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourPertesGainsSurCessionDentreprise"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_AjustementsPourPertesGainsSurCessionDentreprise_8810ae26-a15a-4ccd-ae81-ce8f0a39bc70NotDimensionallyQualified" xlink:type="arc" order="85"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_e5a1122e-0c1e-484c-aeee-2bf2a80ba5b5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_e5a1122e-0c1e-484c-aeee-2bf2a80ba5b5NotDimensionallyQualified" xlink:type="arc" order="86"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles_85197ad1-71de-4bf1-b9e2-0a5cc9349496NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles_85197ad1-71de-4bf1-b9e2-0a5cc9349496NotDimensionallyQualified" xlink:type="arc" order="87"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_585896fc-4889-4a98-a112-2addb53bbefcNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_585896fc-4889-4a98-a112-2addb53bbefcNotDimensionallyQualified" xlink:type="arc" order="88"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDeferredTaxExpense_33191fa7-3cc3-4cf6-a9c8-d18a7940eeeeNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDeferredTaxExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDeferredTaxExpense_33191fa7-3cc3-4cf6-a9c8-d18a7940eeeeNotDimensionallyQualified" xlink:type="arc" order="89"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourVariationDesProvisionsEtAutresPassifsNonCourants_b26bab27-7e47-4150-a5ce-1fd697784e96NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourVariationDesProvisionsEtAutresPassifsNonCourants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_AjustementsPourVariationDesProvisionsEtAutresPassifsNonCourants_b26bab27-7e47-4150-a5ce-1fd697784e96NotDimensionallyQualified" xlink:type="arc" order="90"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_d7cc974a-db2a-4a2a-ae30-e77d9db7a7f5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_d7cc974a-db2a-4a2a-ae30-e77d9db7a7f5NotDimensionallyQualified" xlink:type="arc" order="91"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourImpactDeLaConsommationDesStocksAcquisReevaluesALaJusteValeur_58558fbe-374a-4e36-9fcb-f62a238d7da3NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourImpactDeLaConsommationDesStocksAcquisReevaluesALaJusteValeur"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_AjustementsPourImpactDeLaConsommationDesStocksAcquisReevaluesALaJusteValeur_58558fbe-374a-4e36-9fcb-f62a238d7da3NotDimensionallyQualified" xlink:type="arc" order="92"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss_0b9e75c7-efdb-4414-a075-414b65a8a66eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherAdjustmentsToReconcileProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherAdjustmentsToReconcileProfitLoss_0b9e75c7-efdb-4414-a075-414b65a8a66eNotDimensionallyQualified" xlink:type="arc" order="93"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_e8009410-9134-4944-affa-78793f1507a5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital_e8009410-9134-4944-affa-78793f1507a5NotDimensionallyQualified" xlink:type="arc" order="94"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_7ee52a85-ba2d-449f-92d8-3aa1dd91ddf6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInInventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInInventories_7ee52a85-ba2d-449f-92d8-3aa1dd91ddf6NotDimensionallyQualified" xlink:type="arc" order="95"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable_064402ea-68d3-4ddc-a8b5-6fba6ffb81d4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable_064402ea-68d3-4ddc-a8b5-6fba6ffb81d4NotDimensionallyQualified" xlink:type="arc" order="96"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_2f0ee1d8-ccc6-4b58-add3-4ad39386e3faNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_2f0ee1d8-ccc6-4b58-add3-4ad39386e3faNotDimensionallyQualified" xlink:type="arc" order="97"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourVariationDesAutresActifsCourantsEtAutresPassifsCourants_32edfadd-db9f-4540-b85e-59c40b71b696NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourVariationDesAutresActifsCourantsEtAutresPassifsCourants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_AjustementsPourVariationDesAutresActifsCourantsEtAutresPassifsCourants_32edfadd-db9f-4540-b85e-59c40b71b696NotDimensionallyQualified" xlink:type="arc" order="98"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivitiesContinuingOperations_31c0aa2a-df6f-4fab-a5b8-d0c772956bd5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivitiesContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivitiesContinuingOperations_31c0aa2a-df6f-4fab-a5b8-d0c772956bd5NotDimensionallyQualified" xlink:type="arc" order="99"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivitiesDiscontinuedOperations_8f60f80d-52f7-4d93-a6a1-9e2207d7094aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivitiesDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivitiesDiscontinuedOperations_8f60f80d-52f7-4d93-a6a1-9e2207d7094aNotDimensionallyQualified" xlink:type="arc" order="100"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_48f3d3e7-82ba-4d77-a3f4-d8ba868d7ca9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_48f3d3e7-82ba-4d77-a3f4-d8ba868d7ca9NotDimensionallyQualified" xlink:type="arc" order="101"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_13dd93ac-d4ab-4b65-a3cb-b8ad32bcf323NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_13dd93ac-d4ab-4b65-a3cb-b8ad32bcf323NotDimensionallyQualified" xlink:type="arc" order="102"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_d43058c4-f3d2-42db-804e-0366c2268619NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_d43058c4-f3d2-42db-804e-0366c2268619NotDimensionallyQualified" xlink:type="arc" order="103"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_2c046358-1f6d-4b60-bbdc-4a83b70f0c6cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_2c046358-1f6d-4b60-bbdc-4a83b70f0c6cNotDimensionallyQualified" xlink:type="arc" order="104"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_b6ab2c99-6f2b-482a-86a7-aecfaece6adbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromDisposalsOfPropertyPlantAndEquipmentIntangibleAssetsOtherThanGoodwillInvestmentPropertyAndOtherNoncurrentAssets_b6ab2c99-6f2b-482a-86a7-aecfaece6adbNotDimensionallyQualified" xlink:type="arc" order="105"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_856b7260-b7e7-4ac8-be82-cae5ac480a24NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_856b7260-b7e7-4ac8-be82-cae5ac480a24NotDimensionallyQualified" xlink:type="arc" order="106"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_VariationDesAutresActifsNonCourants_226c60ec-b922-477a-a70c-a48fab51f9a9NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_VariationDesAutresActifsNonCourants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_VariationDesAutresActifsNonCourants_226c60ec-b922-477a-a70c-a48fab51f9a9NotDimensionallyQualified" xlink:type="arc" order="107"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivitiesContinuingOperations_7c3b562b-d88f-4a9f-900d-97e624d1e8e8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivitiesContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivitiesContinuingOperations_7c3b562b-d88f-4a9f-900d-97e624d1e8e8NotDimensionallyQualified" xlink:type="arc" order="108"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivitiesDiscontinuedOperations_9a0241e8-e101-4109-adb5-220cab961ca9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivitiesDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivitiesDiscontinuedOperations_9a0241e8-e101-4109-adb5-220cab961ca9NotDimensionallyQualified" xlink:type="arc" order="109"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_FluxDeTresorerieNetsLiesAuxActivitesAbandonnees_019b071a-a9ee-782c-a3e2-20235101686fNotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_FluxDeTresorerieNetsLiesAuxActivitesAbandonnees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_FluxDeTresorerieNetsLiesAuxActivitesAbandonnees_019b071a-a9ee-782c-a3e2-20235101686fNotDimensionallyQualified" xlink:type="arc" order="110"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_f0bc4477-3986-4233-96fd-059c61dc1edaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_f0bc4477-3986-4233-96fd-059c61dc1edaNotDimensionallyQualified" xlink:type="arc" order="111"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingShares_cf2b0df4-4044-409d-acf0-e0cac1eb7458NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromIssuingShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromIssuingShares_cf2b0df4-4044-409d-acf0-e0cac1eb7458NotDimensionallyQualified" xlink:type="arc" order="112"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities_ae01ebaa-82f3-4713-b4e2-0140848434f6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities_ae01ebaa-82f3-4713-b4e2-0140848434f6NotDimensionallyQualified" xlink:type="arc" order="113"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities_cf0fe52a-5747-470e-a3cc-ee115f53def5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DividendsPaidToNoncontrollingInterestsClassifiedAsFinancingActivities_cf0fe52a-5747-470e-a3cc-ee115f53def5NotDimensionallyQualified" xlink:type="arc" order="114"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_79517b45-e16c-412d-b1c8-8ea93debfe13NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_79517b45-e16c-412d-b1c8-8ea93debfe13NotDimensionallyQualified" xlink:type="arc" order="115"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_7c57853d-51e4-418b-9f9b-8c07836317afNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromNoncurrentBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_7c57853d-51e4-418b-9f9b-8c07836317afNotDimensionallyQualified" xlink:type="arc" order="116"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_280c76fc-35a6-4705-9a6a-1ccb606e0bbbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RepaymentsOfNoncurrentBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_280c76fc-35a6-4705-9a6a-1ccb606e0bbbNotDimensionallyQualified" xlink:type="arc" order="117"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_1f1d0497-dbeb-4885-b6be-ff275bff0096NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_1f1d0497-dbeb-4885-b6be-ff275bff0096NotDimensionallyQualified" xlink:type="arc" order="118"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers_c0902928-ea15-4673-9c49-74dc3e572f1cNotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers_c0902928-ea15-4673-9c49-74dc3e572f1cNotDimensionallyQualified" xlink:type="arc" order="119"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsToAcquireOrRedeemEntitysShares_57aec258-2ad8-41a1-95ff-9a02978821a7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsToAcquireOrRedeemEntitysShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsToAcquireOrRedeemEntitysShares_57aec258-2ad8-41a1-95ff-9a02978821a7NotDimensionallyQualified" xlink:type="arc" order="120"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivitiesContinuingOperations_8d6e6c0f-6616-4e83-b2d9-d1b045a79204NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivitiesContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivitiesContinuingOperations_8d6e6c0f-6616-4e83-b2d9-d1b045a79204NotDimensionallyQualified" xlink:type="arc" order="121"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivitiesDiscontinuedOperations_af2c0d16-bf13-404b-985d-27f87e8713cbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivitiesDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivitiesDiscontinuedOperations_af2c0d16-bf13-404b-985d-27f87e8713cbNotDimensionallyQualified" xlink:type="arc" order="122"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c00d9fab-4290-4940-8247-b937f7ce8460NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_c00d9fab-4290-4940-8247-b937f7ce8460NotDimensionallyQualified" xlink:type="arc" order="123"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_23142b08-61dd-4846-bddb-1e3b8ec88f59NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_23142b08-61dd-4846-bddb-1e3b8ec88f59NotDimensionallyQualified" xlink:type="arc" order="124"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_EffectOfReclassificationOfDiscontinuedOperation_cebcc7a1-db02-4ca2-87b1-30d9eda0a4adNotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_EffectOfReclassificationOfDiscontinuedOperation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_EffectOfReclassificationOfDiscontinuedOperation_cebcc7a1-db02-4ca2-87b1-30d9eda0a4adNotDimensionallyQualified" xlink:type="arc" order="125"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_9d5f4480-af6b-4964-bd67-d5e23345de57NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_9d5f4480-af6b-4964-bd67-d5e23345de57NotDimensionallyQualified" xlink:type="arc" order="126"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfChangesInAccountingPoliciesAccountingEstimatesAndErrorsExplanatory_fa28c627-0707-4c53-840b-b21199b6b4b0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfChangesInAccountingPoliciesAccountingEstimatesAndErrorsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfChangesInAccountingPoliciesAccountingEstimatesAndErrorsExplanatory_fa28c627-0707-4c53-840b-b21199b6b4b0NotDimensionallyQualified" xlink:type="arc" order="127"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_928d5726-05c8-4f80-8d27-df74d98ace27NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_928d5726-05c8-4f80-8d27-df74d98ace27NotDimensionallyQualified" xlink:type="arc" order="128"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_13382517-b5e3-4d53-98c6-a96d502d2bb9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinancialRiskManagementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_13382517-b5e3-4d53-98c6-a96d502d2bb9NotDimensionallyQualified" xlink:type="arc" order="129"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_edfc6f00-ed2b-4640-8c5a-3efd3b4f11feNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_edfc6f00-ed2b-4640-8c5a-3efd3b4f11feNotDimensionallyQualified" xlink:type="arc" order="130"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfNoncurrentAssetsHeldForSaleAndDiscontinuedOperationsExplanatory_a42e2583-a7f9-4a45-bbbb-2eeb7d8768ddNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfNoncurrentAssetsHeldForSaleAndDiscontinuedOperationsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfNoncurrentAssetsHeldForSaleAndDiscontinuedOperationsExplanatory_a42e2583-a7f9-4a45-bbbb-2eeb7d8768ddNotDimensionallyQualified" xlink:type="arc" order="131"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory_e96a7a3b-1c32-4f68-a7fb-8da593dc3844NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory_e96a7a3b-1c32-4f68-a7fb-8da593dc3844NotDimensionallyQualified" xlink:type="arc" order="132"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_04b13a53-9f90-48bd-8119-8b23e1305ebeNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_04b13a53-9f90-48bd-8119-8b23e1305ebeNotDimensionallyQualified" xlink:type="arc" order="133"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfParentEntity_dd28d1a8-3dc6-47c5-bdda-7b039c72e69eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NameOfParentEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfParentEntity_dd28d1a8-3dc6-47c5-bdda-7b039c72e69eNotDimensionallyQualified" xlink:type="arc" order="134"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfUltimateParentOfGroup_77a75faa-8b3a-47e2-9aa2-5604e1203ac1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NameOfUltimateParentOfGroup"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfUltimateParentOfGroup_77a75faa-8b3a-47e2-9aa2-5604e1203ac1NotDimensionallyQualified" xlink:type="arc" order="135"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_d6a9626c-2d0f-4f42-bef6-8cd3ffee3352NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AddressOfRegisteredOfficeOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_d6a9626c-2d0f-4f42-bef6-8cd3ffee3352NotDimensionallyQualified" xlink:type="arc" order="136"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DomicileOfEntity_9d02c322-6532-40b9-a776-019fb2fcbad3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DomicileOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DomicileOfEntity_9d02c322-6532-40b9-a776-019fb2fcbad3NotDimensionallyQualified" xlink:type="arc" order="137"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CountryOfIncorporation_cd614e8b-5e0f-47bc-a242-815f9ade3b39NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CountryOfIncorporation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CountryOfIncorporation_cd614e8b-5e0f-47bc-a242-815f9ade3b39NotDimensionallyQualified" xlink:type="arc" order="138"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LegalFormOfEntity_08c86220-b0dd-44ab-bd17-e474b57c3781NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LegalFormOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LegalFormOfEntity_08c86220-b0dd-44ab-bd17-e474b57c3781NotDimensionallyQualified" xlink:type="arc" order="139"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_b98bc104-572f-4a57-852f-81f845f774fcNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_b98bc104-572f-4a57-852f-81f845f774fcNotDimensionallyQualified" xlink:type="arc" order="140"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PrincipalPlaceOfBusiness_fd921572-262c-4d0b-a81f-286d3c537e9bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PrincipalPlaceOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PrincipalPlaceOfBusiness_fd921572-262c-4d0b-a81f-286d3c537e9bNotDimensionallyQualified" xlink:type="arc" order="141"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGeneralInformationAboutFinancialStatementsExplanatory_a72ce957-070e-42d4-9773-bd219d15264dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfGeneralInformationAboutFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGeneralInformationAboutFinancialStatementsExplanatory_a72ce957-070e-42d4-9773-bd219d15264dNotDimensionallyQualified" xlink:type="arc" order="142"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAuthorisationOfFinancialStatementsExplanatory_3beb3bfb-9abc-485b-ae9b-48e14d5f22e2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAuthorisationOfFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAuthorisationOfFinancialStatementsExplanatory_3beb3bfb-9abc-485b-ae9b-48e14d5f22e2NotDimensionallyQualified" xlink:type="arc" order="143"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_bea8266f-397e-4067-b5d0-e0d9595d00cbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_bea8266f-397e-4067-b5d0-e0d9595d00cbNotDimensionallyQualified" xlink:type="arc" order="144"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfIFRSCompliance_4439375b-4a41-4cc7-ba40-420b88a143efNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfIFRSCompliance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_StatementOfIFRSCompliance_4439375b-4a41-4cc7-ba40-420b88a143efNotDimensionallyQualified" xlink:type="arc" order="145"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_7bf014d5-c750-469d-b95f-13c8f7c74d83NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_7bf014d5-c750-469d-b95f-13c8f7c74d83NotDimensionallyQualified" xlink:type="arc" order="146"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfHyperinflationaryReportingExplanatory_3ad6f791-2b82-48e2-8581-049bd0d53827NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfHyperinflationaryReportingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfHyperinflationaryReportingExplanatory_3ad6f791-2b82-48e2-8581-049bd0d53827NotDimensionallyQualified" xlink:type="arc" order="147"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAdditionalInformationExplanatory_8cfe8cd7-0157-43c9-90d3-cf61441e09adNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAdditionalInformationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAdditionalInformationExplanatory_8cfe8cd7-0157-43c9-90d3-cf61441e09adNotDimensionallyQualified" xlink:type="arc" order="148"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_6ce5f247-3a92-4ef6-bef7-e01c84a92d00NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_6ce5f247-3a92-4ef6-bef7-e01c84a92d00NotDimensionallyQualified" xlink:type="arc" order="149"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_a9952823-7492-4779-a1f0-fe7188e6b675NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBasisOfConsolidationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_a9952823-7492-4779-a1f0-fe7188e6b675NotDimensionallyQualified" xlink:type="arc" order="150"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_ca858588-a46c-4826-86c1-527539e1cd1aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_ca858588-a46c-4826-86c1-527539e1cd1aNotDimensionallyQualified" xlink:type="arc" order="151"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentsInJointVentures_dc12c166-652e-4abf-b762-ed4ca88ad7f6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentsInJointVentures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentsInJointVentures_dc12c166-652e-4abf-b762-ed4ca88ad7f6NotDimensionallyQualified" xlink:type="arc" order="152"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_0982aca6-64c1-49c6-b1fb-079392d82f13NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_0982aca6-64c1-49c6-b1fb-079392d82f13NotDimensionallyQualified" xlink:type="arc" order="153"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_3e9c57ae-9af6-4fe1-b082-5185bd6a373dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_3e9c57ae-9af6-4fe1-b082-5185bd6a373dNotDimensionallyQualified" xlink:type="arc" order="154"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory_48938b8f-5e39-4078-b17e-e59c45be894fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory_48938b8f-5e39-4078-b17e-e59c45be894fNotDimensionallyQualified" xlink:type="arc" order="155"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsAndGoodwillExplanatory_bff24c31-6c74-4761-b3fb-57903cb1624fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsAndGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsAndGoodwillExplanatory_bff24c31-6c74-4761-b3fb-57903cb1624fNotDimensionallyQualified" xlink:type="arc" order="156"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory_cc1aa1a5-20eb-4495-8748-48120d91e1aaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory_cc1aa1a5-20eb-4495-8748-48120d91e1aaNotDimensionallyQualified" xlink:type="arc" order="157"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory_59e58bd3-9c15-47b5-8248-28b56f19b0e3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory_59e58bd3-9c15-47b5-8248-28b56f19b0e3NotDimensionallyQualified" xlink:type="arc" order="158"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForGoodwillExplanatory_d6c6b3bc-697d-4d5b-9f4b-32768e164a0fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForGoodwillExplanatory_d6c6b3bc-697d-4d5b-9f4b-32768e164a0fNotDimensionallyQualified" xlink:type="arc" order="159"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_9508ed0d-8616-409d-9502-fe7f9f0a7ae9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_9508ed0d-8616-409d-9502-fe7f9f0a7ae9NotDimensionallyQualified" xlink:type="arc" order="160"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory_9e00fe20-70b9-408e-8b61-50b7c02befb6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory_9e00fe20-70b9-408e-8b61-50b7c02befb6NotDimensionallyQualified" xlink:type="arc" order="161"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory_12801188-b175-4831-a9cb-44d047f4b844NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory_12801188-b175-4831-a9cb-44d047f4b844NotDimensionallyQualified" xlink:type="arc" order="162"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleAndDiscontinuedOperationsExplanatory_3bf7b1d6-cea5-465a-bd1d-547a2d330544NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleAndDiscontinuedOperationsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleAndDiscontinuedOperationsExplanatory_3bf7b1d6-cea5-465a-bd1d-547a2d330544NotDimensionallyQualified" xlink:type="arc" order="163"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_3ac075fa-f36b-493b-a963-1382ac872ed9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_3ac075fa-f36b-493b-a963-1382ac872ed9NotDimensionallyQualified" xlink:type="arc" order="164"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_890cdcc3-eaa5-426d-9cde-7f98f08fbcedNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_890cdcc3-eaa5-426d-9cde-7f98f08fbcedNotDimensionallyQualified" xlink:type="arc" order="165"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_e5b0b25e-ec6f-460c-89ba-527d4fe0aae9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_e5b0b25e-ec6f-460c-89ba-527d4fe0aae9NotDimensionallyQualified" xlink:type="arc" order="166"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory_82aa9ee6-db71-47ab-9c3a-4c0db6a1e6efNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory_82aa9ee6-db71-47ab-9c3a-4c0db6a1e6efNotDimensionallyQualified" xlink:type="arc" order="167"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsExplanatory_a399016a-2337-404a-92fb-53376a152aadNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDerivativeFinancialInstrumentsExplanatory_a399016a-2337-404a-92fb-53376a152aadNotDimensionallyQualified" xlink:type="arc" order="168"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForOffsettingOfFinancialInstrumentsExplanatory_05b9cc48-1377-47bd-9b0e-5fd482e49c8bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForOffsettingOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForOffsettingOfFinancialInstrumentsExplanatory_05b9cc48-1377-47bd-9b0e-5fd482e49c8bNotDimensionallyQualified" xlink:type="arc" order="169"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForHedgingExplanatory_0661818f-1391-498d-a49b-23478cd5105fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForHedgingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForHedgingExplanatory_0661818f-1391-498d-a49b-23478cd5105fNotDimensionallyQualified" xlink:type="arc" order="170"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_96b84365-f5dc-4c64-9825-81bd030e78c4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_96b84365-f5dc-4c64-9825-81bd030e78c4NotDimensionallyQualified" xlink:type="arc" order="171"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForBorrowingsExplanatory_27acef23-6307-449f-ba53-dd1ef0ef3366NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForBorrowingsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForBorrowingsExplanatory_27acef23-6307-449f-ba53-dd1ef0ef3366NotDimensionallyQualified" xlink:type="arc" order="172"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_6a5dcaaa-882d-4943-87fb-7ba846465a57NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_6a5dcaaa-882d-4943-87fb-7ba846465a57NotDimensionallyQualified" xlink:type="arc" order="173"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDerecognitionOfFinancialInstrumentsExplanatory_d17f327c-ef31-4edb-adf9-a9800d4f3ef4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDerecognitionOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDerecognitionOfFinancialInstrumentsExplanatory_d17f327c-ef31-4edb-adf9-a9800d4f3ef4NotDimensionallyQualified" xlink:type="arc" order="174"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForMeasuringInventories_f4400a97-22d9-4bcd-9a81-da0c523bc796NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForMeasuringInventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForMeasuringInventories_f4400a97-22d9-4bcd-9a81-da0c523bc796NotDimensionallyQualified" xlink:type="arc" order="175"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyToDetermineComponentsOfCashAndCashEquivalents_86d68cb4-a07c-4108-9661-e71e68718503NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyToDetermineComponentsOfCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyToDetermineComponentsOfCashAndCashEquivalents_86d68cb4-a07c-4108-9661-e71e68718503NotDimensionallyQualified" xlink:type="arc" order="176"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTreasurySharesExplanatory_161e47dc-5e78-4859-9862-718b2b71a740NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForTreasurySharesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTreasurySharesExplanatory_161e47dc-5e78-4859-9862-718b2b71a740NotDimensionallyQualified" xlink:type="arc" order="177"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_2da6d112-91f1-4066-805d-22bf69429638NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_2da6d112-91f1-4066-805d-22bf69429638NotDimensionallyQualified" xlink:type="arc" order="178"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory_ded3f104-a57a-4b48-9803-0a4451c9fcebNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory_ded3f104-a57a-4b48-9803-0a4451c9fcebNotDimensionallyQualified" xlink:type="arc" order="179"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_dc197936-d9e2-4fa0-9c35-378bb53e97b5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_dc197936-d9e2-4fa0-9c35-378bb53e97b5NotDimensionallyQualified" xlink:type="arc" order="180"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForExpensesExplanatory_24d38b6c-dc0b-4d53-8fb8-a15c1bc0d4a6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForExpensesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForExpensesExplanatory_24d38b6c-dc0b-4d53-8fb8-a15c1bc0d4a6NotDimensionallyQualified" xlink:type="arc" order="181"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory_9918a87d-7286-45d6-83ae-bc522ceab15eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory_9918a87d-7286-45d6-83ae-bc522ceab15eNotDimensionallyQualified" xlink:type="arc" order="182"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory_8213aa1d-d10d-4643-9820-9d2b529a1556NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory_8213aa1d-d10d-4643-9820-9d2b529a1556NotDimensionallyQualified" xlink:type="arc" order="183"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_a899b237-7287-4529-b0c8-013d443829c2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_a899b237-7287-4529-b0c8-013d443829c2NotDimensionallyQualified" xlink:type="arc" order="184"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognisingDifferenceBetweenFairValueAtInitialRecognitionAndAmountDeterminedUsingValuationTechniqueExplanatory_dcb552fd-7184-412b-a852-ebfad819cfdbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForRecognisingDifferenceBetweenFairValueAtInitialRecognitionAndAmountDeterminedUsingValuationTechniqueExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognisingDifferenceBetweenFairValueAtInitialRecognitionAndAmountDeterminedUsingValuationTechniqueExplanatory_dcb552fd-7184-412b-a852-ebfad819cfdbNotDimensionallyQualified" xlink:type="arc" order="185"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_DescriptionOfOtherAccountingPoliciesRelevantToUnderstandingOfFinancialStatements_b86ba85a-9867-425f-bd7b-bd3057dde297NotDimensionallyQualified" xlink:href="sny-2025-12-31.xsd#sny_DescriptionOfOtherAccountingPoliciesRelevantToUnderstandingOfFinancialStatements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_sny_DescriptionOfOtherAccountingPoliciesRelevantToUnderstandingOfFinancialStatements_b86ba85a-9867-425f-bd7b-bd3057dde297NotDimensionallyQualified" xlink:type="arc" order="186"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory_aded14ec-8f1c-4361-9922-482597bf8b63NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory_aded14ec-8f1c-4361-9922-482597bf8b63NotDimensionallyQualified" xlink:type="arc" order="187"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_27d956f0-366c-478e-a413-3dc30f2f1640NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_27d956f0-366c-478e-a413-3dc30f2f1640NotDimensionallyQualified" xlink:type="arc" order="188"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDeferredIncomeTaxExplanatory_bcfe9baa-1212-44b6-81bb-bb572673548cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForDeferredIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDeferredIncomeTaxExplanatory_bcfe9baa-1212-44b6-81bb-bb572673548cNotDimensionallyQualified" xlink:type="arc" order="189"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_901a179d-76ca-4b7b-a06b-ce86d0e5a7d9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_901a179d-76ca-4b7b-a06b-ce86d0e5a7d9NotDimensionallyQualified" xlink:type="arc" order="190"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_0deaf6c4-19e7-44fe-9dea-76098326ea73NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_0deaf6c4-19e7-44fe-9dea-76098326ea73NotDimensionallyQualified" xlink:type="arc" order="191"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForEarningsPerShareExplanatory_e7215ed9-2841-4e19-aa12-f7a146a633c9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForEarningsPerShareExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForEarningsPerShareExplanatory_e7215ed9-2841-4e19-aa12-f7a146a633c9NotDimensionallyQualified" xlink:type="arc" order="192"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory_504ce9cd-8584-47da-a58d-ddc7e026b02bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory_504ce9cd-8584-47da-a58d-ddc7e026b02bNotDimensionallyQualified" xlink:type="arc" order="193"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_f4834e49-3c2f-4dc5-b9b7-f483ea03d8d3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_f4834e49-3c2f-4dc5-b9b7-f483ea03d8d3NotDimensionallyQualified" xlink:type="arc" order="194"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfLeasesExplanatory_5eec993b-5fa7-4ddd-b147-e608adfa6a6aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfLeasesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfLeasesExplanatory_5eec993b-5fa7-4ddd-b147-e608adfa6a6aNotDimensionallyQualified" xlink:type="arc" order="195"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIntangibleAssetsAndGoodwillExplanatory_45b59847-901d-4372-93ee-ff503c03c03bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfIntangibleAssetsAndGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIntangibleAssetsAndGoodwillExplanatory_45b59847-901d-4372-93ee-ff503c03c03bNotDimensionallyQualified" xlink:type="arc" order="196"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_f06a5676-56b1-4112-8bc4-a885240957f5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_f06a5676-56b1-4112-8bc4-a885240957f5NotDimensionallyQualified" xlink:type="arc" order="197"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory_518ae22c-3fa5-415e-8be8-a016ab060554NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory_518ae22c-3fa5-415e-8be8-a016ab060554NotDimensionallyQualified" xlink:type="arc" order="198"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_b2640710-5779-4978-ae47-e27936dcef43NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_b2640710-5779-4978-ae47-e27936dcef43NotDimensionallyQualified" xlink:type="arc" order="199"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfJointVenturesExplanatory_39f39881-4ebd-4617-abc6-b978d9eb2ab6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfJointVenturesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfJointVenturesExplanatory_39f39881-4ebd-4617-abc6-b978d9eb2ab6NotDimensionallyQualified" xlink:type="arc" order="200"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherNoncurrentAssetsExplanatory_febb25fb-ed28-4e94-8112-30fea1f8d3ddNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherNoncurrentAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherNoncurrentAssetsExplanatory_febb25fb-ed28-4e94-8112-30fea1f8d3ddNotDimensionallyQualified" xlink:type="arc" order="201"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleExplanatory_017d05f5-d71d-44a0-8920-b1f135877ab3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfNoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSaleExplanatory_017d05f5-d71d-44a0-8920-b1f135877ab3NotDimensionallyQualified" xlink:type="arc" order="202"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInventoriesExplanatory_09041688-e28f-44d1-a3a0-b99b7879e055NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInventoriesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInventoriesExplanatory_09041688-e28f-44d1-a3a0-b99b7879e055NotDimensionallyQualified" xlink:type="arc" order="203"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_f5f9fab2-db20-4980-90a4-1708c4bab68cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_f5f9fab2-db20-4980-90a4-1708c4bab68cNotDimensionallyQualified" xlink:type="arc" order="204"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherCurrentAssetsExplanatory_49c99476-daba-45f7-b86b-c5ccdd9f7f5eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherCurrentAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherCurrentAssetsExplanatory_49c99476-daba-45f7-b86b-c5ccdd9f7f5eNotDimensionallyQualified" xlink:type="arc" order="205"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_997b8bc5-2273-4b4b-8363-6fe7884a9643NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_997b8bc5-2273-4b4b-8363-6fe7884a9643NotDimensionallyQualified" xlink:type="arc" order="206"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory_5502a61e-87d6-4832-a161-3c41a1b2e8cdNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCashAndCashEquivalentsExplanatory_5502a61e-87d6-4832-a161-3c41a1b2e8cdNotDimensionallyQualified" xlink:type="arc" order="207"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDeferredTaxesExplanatory_47823c96-0dba-4430-b716-8c575885bde9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDeferredTaxesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDeferredTaxesExplanatory_47823c96-0dba-4430-b716-8c575885bde9NotDimensionallyQualified" xlink:type="arc" order="208"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_c6b82b59-3e32-4359-88b3-b5be33dadee5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_c6b82b59-3e32-4359-88b3-b5be33dadee5NotDimensionallyQualified" xlink:type="arc" order="209"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIssuedCapitalExplanatory_dd95a23d-e1c4-4b27-b492-2425afe993eaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfIssuedCapitalExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIssuedCapitalExplanatory_dd95a23d-e1c4-4b27-b492-2425afe993eaNotDimensionallyQualified" xlink:type="arc" order="210"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_d8b08399-a336-4c78-89f6-0d6825de9b5aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_d8b08399-a336-4c78-89f6-0d6825de9b5aNotDimensionallyQualified" xlink:type="arc" order="211"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_ee8bb0ca-32f5-4a88-bd12-db906e30eb58NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfTreasurySharesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_ee8bb0ca-32f5-4a88-bd12-db906e30eb58NotDimensionallyQualified" xlink:type="arc" order="212"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_809f38e5-2809-4963-b190-4bd8f8737e15NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_809f38e5-2809-4963-b190-4bd8f8737e15NotDimensionallyQualified" xlink:type="arc" order="213"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDebtSecuritiesExplanatory_2f24f0d0-b1e6-49de-b738-530c207ccc90NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDebtSecuritiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDebtSecuritiesExplanatory_2f24f0d0-b1e6-49de-b738-530c207ccc90NotDimensionallyQualified" xlink:type="arc" order="214"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_e5c86f4d-e57a-4516-85ab-abddd92ba96fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBorrowingsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_e5c86f4d-e57a-4516-85ab-abddd92ba96fNotDimensionallyQualified" xlink:type="arc" order="215"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherLiabilitiesExplanatory_798e63fa-39a6-44a7-a419-bc4904e52715NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherLiabilitiesExplanatory_798e63fa-39a6-44a7-a419-bc4904e52715NotDimensionallyQualified" xlink:type="arc" order="216"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBusinessCombinationsExplanatory_1ffdbde0-f7cd-40bf-ad80-939599181239NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfBusinessCombinationsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBusinessCombinationsExplanatory_1ffdbde0-f7cd-40bf-ad80-939599181239NotDimensionallyQualified" xlink:type="arc" order="217"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfProvisionsExplanatory_b71e6996-bab8-4eae-9898-754940313f30NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfProvisionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfProvisionsExplanatory_b71e6996-bab8-4eae-9898-754940313f30NotDimensionallyQualified" xlink:type="arc" order="218"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEmployeeBenefitsExplanatory_df32bf99-a414-488b-93d6-b416473cd2c7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEmployeeBenefitsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEmployeeBenefitsExplanatory_df32bf99-a414-488b-93d6-b416473cd2c7NotDimensionallyQualified" xlink:type="arc" order="219"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherNoncurrentLiabilitiesExplanatory_339b7238-3dce-4505-b58f-7dfaab8c6623NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherNoncurrentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherNoncurrentLiabilitiesExplanatory_339b7238-3dce-4505-b58f-7dfaab8c6623NotDimensionallyQualified" xlink:type="arc" order="220"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory_d41f38ad-a93d-4296-bf84-ff30c650cdf0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherCurrentLiabilitiesExplanatory_d41f38ad-a93d-4296-bf84-ff30c650cdf0NotDimensionallyQualified" xlink:type="arc" order="221"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDerivativeFinancialInstrumentsExplanatory_16ad1df0-77e8-45d9-a777-a4b99dc1871cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfDerivativeFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDerivativeFinancialInstrumentsExplanatory_16ad1df0-77e8-45d9-a777-a4b99dc1871cNotDimensionallyQualified" xlink:type="arc" order="222"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_ab893728-891d-4dcd-99c5-581464a942d2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_ab893728-891d-4dcd-99c5-581464a942d2NotDimensionallyQualified" xlink:type="arc" order="223"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCommitmentsExplanatory_99cf43be-dacb-444a-9b7e-9968ea72eee8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfCommitmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCommitmentsExplanatory_99cf43be-dacb-444a-9b7e-9968ea72eee8NotDimensionallyQualified" xlink:type="arc" order="224"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfContingentLiabilitiesExplanatory_220b8c63-5939-4c55-82a7-84f0549281d9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfContingentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfContingentLiabilitiesExplanatory_220b8c63-5939-4c55-82a7-84f0549281d9NotDimensionallyQualified" xlink:type="arc" order="225"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory_d0c896b2-7ed1-463f-843a-6e3132b279aaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory_d0c896b2-7ed1-463f-843a-6e3132b279aaNotDimensionallyQualified" xlink:type="arc" order="226"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory_591229fb-35c9-4348-8cb4-4a2d2f2c54d3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory_591229fb-35c9-4348-8cb4-4a2d2f2c54d3NotDimensionallyQualified" xlink:type="arc" order="227"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherOperatingExpenseExplanatory_14707e48-8d27-4238-9c6b-f2a7bcf43b6dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfOtherOperatingExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherOperatingExpenseExplanatory_14707e48-8d27-4238-9c6b-f2a7bcf43b6dNotDimensionallyQualified" xlink:type="arc" order="228"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfProfitLossFromOperatingActivitiesExplanatory_57bd1dc3-e385-4fd8-8f80-569d9a7789afNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfProfitLossFromOperatingActivitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfProfitLossFromOperatingActivitiesExplanatory_57bd1dc3-e385-4fd8-8f80-569d9a7789afNotDimensionallyQualified" xlink:type="arc" order="229"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_12773ad0-7e53-4e7a-9936-340469fefb3fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_12773ad0-7e53-4e7a-9936-340469fefb3fNotDimensionallyQualified" xlink:type="arc" order="230"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceIncomeExplanatory_394934c7-b7a1-4005-9543-c9ba536b5953NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinanceIncomeExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceIncomeExplanatory_394934c7-b7a1-4005-9543-c9ba536b5953NotDimensionallyQualified" xlink:type="arc" order="231"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceCostExplanatory_3e1e3d87-041b-478d-85eb-a810d2f56db2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfFinanceCostExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceCostExplanatory_3e1e3d87-041b-478d-85eb-a810d2f56db2NotDimensionallyQualified" xlink:type="arc" order="232"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRelatedPartyExplanatory_2b9abfe4-ad10-44ba-9278-ff22b7e95032NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRelatedPartyExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRelatedPartyExplanatory_2b9abfe4-ad10-44ba-9278-ff22b7e95032NotDimensionallyQualified" xlink:type="arc" order="233"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory_aa763476-bada-4cdf-a70d-858d8b4d8c5eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory_aa763476-bada-4cdf-a70d-858d8b4d8c5eNotDimensionallyQualified" xlink:type="arc" order="234"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_403c2a2a-14b9-4e64-b38e-7cbb499c832fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_403c2a2a-14b9-4e64-b38e-7cbb499c832fNotDimensionallyQualified" xlink:type="arc" order="235"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRevenueExplanatory_4975c961-8e78-49ef-bee5-c5e65f8049f0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfRevenueExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRevenueExplanatory_4975c961-8e78-49ef-bee5-c5e65f8049f0NotDimensionallyQualified" xlink:type="arc" order="236"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAuditorsRemunerationExplanatory_8f9ccaa3-8764-42d9-a9fb-af6fd7acd159NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfAuditorsRemunerationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAuditorsRemunerationExplanatory_8f9ccaa3-8764-42d9-a9fb-af6fd7acd159NotDimensionallyQualified" xlink:type="arc" order="237"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_f1c71ef8-5f5f-4fc7-ba13-19670e78d84aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_f1c71ef8-5f5f-4fc7-ba13-19670e78d84aNotDimensionallyQualified" xlink:type="arc" order="238"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_3b1d1a45-39a9-4d56-93dd-4ff21c10a0d7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_3b1d1a45-39a9-4d56-93dd-4ff21c10a0d7NotDimensionallyQualified" xlink:type="arc" order="239"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.sanofi.com/role/Anchoring" xlink:type="simple" xlink:href="sny-2025-12-31.xsd#Anchoring"/>
  <link:definitionLink xlink:role="http://www.sanofi.com/role/Anchoring" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_sny_AdjustmentsForNonCurrentFinancialAssetsAndDeferredTaxExpense_019c278d-26b8-7dbc-ae09-7c56e9ee03dc" xlink:href="sny-2025-12-31.xsd#sny_AdjustmentsForNonCurrentFinancialAssetsAndDeferredTaxExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_sny_AdjustmentsForNonCurrentFinancialAssetsAndDeferredTaxExpense_019c278d-26b8-7dbc-ae09-7c56e9ee03dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles_10d0f6a7-da0a-45fb-9be5-ed1eeebc933d" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" xlink:to="loc_sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles_10d0f6a7-da0a-45fb-9be5-ed1eeebc933d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpenseAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpenseAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles_10d0f6a7-da0a-45fb-9be5-ed1eeebc933d" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpenseAndImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLossPropertyPlantAndEquipment" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLossPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_AjustementsPourAmortissementsEtDepreciationsDesImmobilisationsCorporellesDroitsDutilisationEtImmobilisationsIncorporelles_10d0f6a7-da0a-45fb-9be5-ed1eeebc933d" xlink:to="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLossPropertyPlantAndEquipment" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourImpactDeLaConsommationDesStocksAcquisReevaluesALaJusteValeur_70875c5c-7012-4339-9531-b5728982e56e" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourImpactDeLaConsommationDesStocksAcquisReevaluesALaJusteValeur"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" xlink:to="loc_sny_AjustementsPourImpactDeLaConsommationDesStocksAcquisReevaluesALaJusteValeur_70875c5c-7012-4339-9531-b5728982e56e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourPertesGainsSurCessionDentreprise_7050b19a-eedf-4615-8346-8fe7f884a26b" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourPertesGainsSurCessionDentreprise"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForReconcileProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForReconcileProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AdjustmentsForReconcileProfitLoss" xlink:to="loc_sny_AjustementsPourPertesGainsSurCessionDentreprise_7050b19a-eedf-4615-8346-8fe7f884a26b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourVariationDesAutresActifsCourantsEtAutresPassifsCourants_5e17202c-e44c-4f75-a48f-ce8e7cfbd7ce" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourVariationDesAutresActifsCourantsEtAutresPassifsCourants"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherCurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInOtherCurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherCurrentLiabilities" xlink:to="loc_sny_AjustementsPourVariationDesAutresActifsCourantsEtAutresPassifsCourants_5e17202c-e44c-4f75-a48f-ce8e7cfbd7ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AjustementsPourVariationDesProvisionsEtAutresPassifsNonCourants_f4e845af-9755-48d0-b690-25b90f0cf584" xlink:href="sny-2025-12-31.xsd#sny_AjustementsPourVariationDesProvisionsEtAutresPassifsNonCourants"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperationsBeforeChangesInWorkingCapital" xlink:to="loc_sny_AjustementsPourVariationDesProvisionsEtAutresPassifsNonCourants_f4e845af-9755-48d0-b690-25b90f0cf584" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDautreVariationDesInteretsNonControlantsCapitauxPropres_532ea285-d3f5-4297-86c7-071c3f66e2c1" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDautreVariationDesInteretsNonControlantsCapitauxPropres"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughChangesInOwnershipInterestsInSubsidiariesThatDoNotResultInLossOfControl" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDautreVariationDesInteretsNonControlantsCapitauxPropres_532ea285-d3f5-4297-86c7-071c3f66e2c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDautresVariationsLieesALemissionDactionsGratuitesCapitauxPropres_fed7bcd6-5918-4b97-80a1-aa7a49cf61e1" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDautresVariationsLieesALemissionDactionsGratuitesCapitauxPropres"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDautresVariationsLieesALemissionDactionsGratuitesCapitauxPropres_fed7bcd6-5918-4b97-80a1-aa7a49cf61e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsAugmentationDeCapitalReserveesAuxSalariesCapitauxPropres_cbbd39d1-f8fc-4997-af74-9c06c566b378" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsAugmentationDeCapitalReserveesAuxSalariesCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsAugmentationDeCapitalReserveesAuxSalariesCapitauxPropres_cbbd39d1-f8fc-4997-af74-9c06c566b378" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEffetDimpotsLieALaLeveeDoptionsCapitauxPropres_0822ad39-70a4-4d6b-b2e9-ddef8e919db0" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEffetDimpotsLieALaLeveeDoptionsCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEffetDimpotsLieALaLeveeDoptionsCapitauxPropres_0822ad39-70a4-4d6b-b2e9-ddef8e919db0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEmissionDactionsGratuitesEtAttributionDefinitiveDactionsGratuitesExistantesCapitauxPropres_052c03f8-fcb5-4714-a8b1-b566dd9ea280" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEmissionDactionsGratuitesEtAttributionDefinitiveDactionsGratuitesExistantesCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsEmissionDactionsGratuitesEtAttributionDefinitiveDactionsGratuitesExistantesCapitauxPropres_052c03f8-fcb5-4714-a8b1-b566dd9ea280" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsValeurDesServicesObtenusDesSalariesCapitauxPropres_2accc3dd-e1c5-4782-a750-b8a3900a4e7c" xlink:href="sny-2025-12-31.xsd#sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsValeurDesServicesObtenusDesSalariesCapitauxPropres"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_sny_AugmentationDiminutionParLeBiaisDePaiementsEnActionsValeurDesServicesObtenusDesSalariesCapitauxPropres_2accc3dd-e1c5-4782-a750-b8a3900a4e7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_AutresProfitsPertesLitiges_d8110335-c36e-49d4-95db-ac5e0250a972" xlink:href="sny-2025-12-31.xsd#sny_AutresProfitsPertesLitiges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities" xlink:to="loc_sny_AutresProfitsPertesLitiges_d8110335-c36e-49d4-95db-ac5e0250a972" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnLitigationSettlements" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnLitigationSettlements"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_AutresProfitsPertesLitiges_d8110335-c36e-49d4-95db-ac5e0250a972" xlink:to="loc_ifrs-full_GainsLossesOnLitigationSettlements" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherGainsLosses" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_AutresProfitsPertesLitiges_d8110335-c36e-49d4-95db-ac5e0250a972" xlink:to="loc_ifrs-full_OtherGainsLosses" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_DividendesRecusDesSocietesNonConsolideesClassesDansLesActivitesOperationnelles_80948232-a2f9-490a-be3d-e75a421f6d23" xlink:href="sny-2025-12-31.xsd#sny_DividendesRecusDesSocietesNonConsolideesClassesDansLesActivitesOperationnelles"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsReceivedClassifiedAsOperatingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsReceivedClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_DividendsReceivedClassifiedAsOperatingActivities" xlink:to="loc_sny_DividendesRecusDesSocietesNonConsolideesClassesDansLesActivitesOperationnelles_80948232-a2f9-490a-be3d-e75a421f6d23" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_EffectOfReclassificationOfDiscontinuedOperation_0e972064-519d-4206-95f0-9fcb5ea57773" xlink:href="sny-2025-12-31.xsd#sny_EffectOfReclassificationOfDiscontinuedOperation"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges" xlink:to="loc_sny_EffectOfReclassificationOfDiscontinuedOperation_0e972064-519d-4206-95f0-9fcb5ea57773" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_FluxDeTresorerieNetsLiesAuxActivitesAbandonnees_74c88c88-6fb3-44c8-ba84-afcbeb62d552" xlink:href="sny-2025-12-31.xsd#sny_FluxDeTresorerieNetsLiesAuxActivitesAbandonnees"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_sny_FluxDeTresorerieNetsLiesAuxActivitesAbandonnees_74c88c88-6fb3-44c8-ba84-afcbeb62d552" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_FluxDeTresorerieProvenantDeUtilisesDansLaugmentationDiminutionDesEmpruntsCourantsEtDautresInstrumentsFinanciers_f1c60518-2d72-4154-b07e-e5d54db49c8e" xlink:href="sny-2025-12-31.xsd#sny_FluxDeTresorerieProvenantDeUtilisesDansLaugmentationDiminutionDesEmpruntsCourantsEtDautresInstrumentsFinanciers"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_sny_FluxDeTresorerieProvenantDeUtilisesDansLaugmentationDiminutionDesEmpruntsCourantsEtDautresInstrumentsFinanciers_f1c60518-2d72-4154-b07e-e5d54db49c8e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers_b5ca8703-fa8a-474b-81a2-26e374e8bca0" xlink:href="sny-2025-12-31.xsd#sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_sny_FluxDeTresorerieResultantUtilisesDansLeCadreDempruntsAMoinsDunAnEtAutresInstrumentsFinanciers_b5ca8703-fa8a-474b-81a2-26e374e8bca0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_OtherComprehensiveIncomeFromContinuingOperations_b7a1ec32-a757-48ae-8be2-6f00e898bf75" xlink:href="sny-2025-12-31.xsd#sny_OtherComprehensiveIncomeFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherComprehensiveIncome" xlink:to="loc_sny_OtherComprehensiveIncomeFromContinuingOperations_b7a1ec32-a757-48ae-8be2-6f00e898bf75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_OtherComprehensiveIncomeFromDiscontinuedOperations_95afbbb8-7afd-47d8-a55d-59e9cf642f7f" xlink:href="sny-2025-12-31.xsd#sny_OtherComprehensiveIncomeFromDiscontinuedOperations"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherComprehensiveIncome" xlink:to="loc_sny_OtherComprehensiveIncomeFromDiscontinuedOperations_95afbbb8-7afd-47d8-a55d-59e9cf642f7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_PassifsCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_fe6a335d-9ea3-4a2c-b622-9a726b249f7f" xlink:href="sny-2025-12-31.xsd#sny_PassifsCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination" xlink:to="loc_sny_PassifsCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_fe6a335d-9ea3-4a2c-b622-9a726b249f7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_PassifsNonCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_6b4fb558-2f4b-4bd8-adca-7776be452186" xlink:href="sny-2025-12-31.xsd#sny_PassifsNonCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ContingentLiabilitiesRecognisedInBusinessCombination" xlink:to="loc_sny_PassifsNonCourantsLiesADesRegroupementsDentreprisesEtADesInteretsNonControlants_6b4fb558-2f4b-4bd8-adca-7776be452186" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProfitsPertesSurInstrumentsDeDetteEnActifsFinanciersAvantImpot_b79e001d-78a8-4cd1-baa7-9a9718e41181" xlink:href="sny-2025-12-31.xsd#sny_ProfitsPertesSurInstrumentsDeDetteEnActifsFinanciersAvantImpot"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax" xlink:to="loc_sny_ProfitsPertesSurInstrumentsDeDetteEnActifsFinanciersAvantImpot_b79e001d-78a8-4cd1-baa7-9a9718e41181" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProvisionsEtAutresPassifsCourants_9365f8d6-2f20-4068-a45b-23ff9d7a0564" xlink:href="sny-2025-12-31.xsd#sny_ProvisionsEtAutresPassifsCourants"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CurrentLiabilities" xlink:to="loc_sny_ProvisionsEtAutresPassifsCourants_9365f8d6-2f20-4068-a45b-23ff9d7a0564" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_ProvisionsEtAutresPassifsCourants_9365f8d6-2f20-4068-a45b-23ff9d7a0564" xlink:to="loc_ifrs-full_OtherCurrentLiabilities" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentProvisions" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentProvisions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_ProvisionsEtAutresPassifsCourants_9365f8d6-2f20-4068-a45b-23ff9d7a0564" xlink:to="loc_ifrs-full_CurrentProvisions" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ProvisionsEtAutresPassifsNonCourants_a0982078-be7c-44fc-8f89-e5846cafba7c" xlink:href="sny-2025-12-31.xsd#sny_ProvisionsEtAutresPassifsNonCourants"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_NoncurrentLiabilities" xlink:to="loc_sny_ProvisionsEtAutresPassifsNonCourants_a0982078-be7c-44fc-8f89-e5846cafba7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisions" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentProvisions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_ProvisionsEtAutresPassifsNonCourants_a0982078-be7c-44fc-8f89-e5846cafba7c" xlink:to="loc_ifrs-full_NoncurrentProvisions" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_ProvisionsEtAutresPassifsNonCourants_a0982078-be7c-44fc-8f89-e5846cafba7c" xlink:to="loc_ifrs-full_OtherNoncurrentLiabilities" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_ResultatAvantImpotsEtSocietesMisesEnEquivalence_6592327f-1414-4adc-8a67-73bdd7ae5632" xlink:href="sny-2025-12-31.xsd#sny_ResultatAvantImpotsEtSocietesMisesEnEquivalence"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromContinuingOperations" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ProfitLossFromContinuingOperations" xlink:to="loc_sny_ResultatAvantImpotsEtSocietesMisesEnEquivalence_6592327f-1414-4adc-8a67-73bdd7ae5632" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_sny_ResultatAvantImpotsEtSocietesMisesEnEquivalence_6592327f-1414-4adc-8a67-73bdd7ae5632" xlink:to="loc_ifrs-full_ProfitLossBeforeTax" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_TaxeSurAnnulationDactions_7c859a45-09c9-4882-b073-071e5537735f" xlink:href="sny-2025-12-31.xsd#sny_TaxeSurAnnulationDactions"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ChangesInEquity" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ChangesInEquity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_sny_TaxeSurAnnulationDactions_7c859a45-09c9-4882-b073-071e5537735f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocieteAbandonnees_e0fbd924-5f36-42db-9194-db905961bebe" xlink:href="sny-2025-12-31.xsd#sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocieteAbandonnees"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent" xlink:to="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocieteAbandonnees_e0fbd924-5f36-42db-9194-db905961bebe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocietePoursuiviesMere_da31e2f2-6b84-4e7e-802a-5066f430d9e2" xlink:href="sny-2025-12-31.xsd#sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocietePoursuiviesMere"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent" xlink:to="loc_sny_TotalDuResultatGlobalAttribuableAuxProprietairesDeLaSocietePoursuiviesMere_da31e2f2-6b84-4e7e-802a-5066f430d9e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_sny_VariationDesAutresActifsNonCourants_b9f3cf75-b180-4b33-a731-29f313bf4cad" xlink:href="sny-2025-12-31.xsd#sny_VariationDesAutresActifsNonCourants"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_sny_VariationDesAutresActifsNonCourants_b9f3cf75-b180-4b33-a731-29f313bf4cad" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
