Vyepti
®
(eptinezumab) delivered very strong growth in the
first six months of 2026, with revenue reaching DKK 2,865
million, an increase of +46% CER (+36% DKK). Vyepti
®
maintained its strong momentum across regions. In the
U.S., Vyepti
®
continued to grow in the first six months of
2026, maintaining its position as the fastest-growing anti-
calcitonin gene-related peptide (aCGRP) in the market and
reaching a market share of 11.6% in May. Growth was
driven by continued expansion of the existing patient
base, improved persistency, increased new patient starts,
Vyepti Infusion Network enrollments and prescription-to-
fill conversion. TRx increased by +41.4% year to date
through June 2026 compared to the same period last year.
U.S. Vyepti
®
sales grew +47% CER in the first six months of
2026. In Europe and International Operations, Vyepti
®
maintained strong growth momentum into the first six
months of 2026 delivering +53% CER and +11% CER
growth, respectively, compared to the same period last
year. Excluding the one-time revenue from inventory
build, growth in Europe was +46% CER and in International
Operations +10% CER. This was driven by continued
strong demand growth across key markets, particularly
France, Spain and Canada. In the second quarter of 2026,
Vyepti
®
demand, measured in treatment days, outpaced
competitors in France and Spain, reaching market shares
of 72% (+5.5 percentage points year-over-year) and 14%
(+2.8 percentage points year-over-year), respectively,
while demand in Canada increased by +18% year-over-
year. The revenue distribution by region was 87%, 10%
and 3% in the U.S., Europe and International Operations,
respectively. The largest markets are the U.S., France,
Spain, Canada and Germany.
Brintellix
®
/Trintellix
®
(vortioxetine) revenue reached
DKK 2,331 million and remained flat at CER (-2% DKK). The
one-time revenue from inventory build in Partner Markets
impacted the growth in the first six months of 2026.
Excluding this effect, the growth was -5% CER (-8% DKK).
In Europe, Brintellix
®
remained an important growth
brand, with performance rebounding in the second
quarter of 2026 following softer momentum in the first
quarter of 2026, driven by reduced promotional activity as
anticipated. Key European markets delivered double-digit
growth in the second quarter of 2026. In International
Operations, performance remained pressured,
particularly in Canada following generic entry in June 2025
and in China due to post–volume-based procurement
(VBP) pressure. This was partly offset by continued
momentum in selected markets, including Japan, where
Trintellix
®
exceeded 13% market share during the second
quarter of 2026, as well as growth in Australia and Korea.
Excluding the one-time revenue from inventory build,
growth in Europe was +3% CER and in International
Operations -15% CER. In the U.S., Trintellix
®
reflects the
effect of the Takeda transition, effective 1 January 2025,
and is showing steady performance in line with
expectations for the transition. The revenue distribution
by region was 25%, 47% and 28% in the U.S., Europe and
International Operations, respectively. The largest
markets for this product are the U.S., Spain, Italy, Japan
and Mexico.
Abilify LAI franchise revenue reached DKK 1,970 million
and grew +7% CER (+4% DKK). The Abilify LAI franchise in
the U.S. continued to grow in the first six months of 2026,
supported by increased demand volume and continued
uptake of Abilify Asimtufii
®
. The franchise grew by
+10% CER in the first six months of 2026, with Abilify
Maintena
®
growing +6% CER and Abilify Asimtufii
®
growing +32% CER compared to the same period last year.
Abilify Asimtufii
®
TRx volume grew by +31% year-over-year
on a rolling 3-month basis, reaching a market share
of 4.5% in April 2026, as Lundbeck continued to source
patients from oral aripiprazole. In Europe, the Abilify LAI
franchise grew +5% CER in the first six months of 2026,
driven by uptake of Abilify Maintena
®
960 mg/Abilify
Asimtufii
®
and encouraging conversion from Abilify
Maintena
®
with the delayed entry of generic competition.
Excluding the one-time revenue from inventory build,
Abilify LAI franchise revenue in Europe declined -1% CER
in the first six months of 2026. Franchise performance was
affected by prior-year’s gross-to-net comparator effects of
government-mandated rebates and paybacks (in Italy and
the UK in the first quarter of 2026). Adjusted for these
effects and excluding revenue from inventory build,
underlying franchise growth in Europe was +4% CER in the
first six months of 2026. This was supported by conversion
to the two-month formulation, reaching 42% in Spain, 25%
in France and 23% in Italy. In International Operations the
Abilify LAI franchise grew +6% CER in the first six months
of 2026, supported by Canada and Australia, with market
share reaching 40% in Canada and 37% in Australia in the
second quarter of 2026, up 1.5 and 1.0 percentage points,
respectively, compared to the same period last year.
Growth was partly offset by Partner Market phasing,
where shipments were accelerated earlier in the period
compared to last year. Excluding the one-time revenue
from inventory build, revenue in International Operations
was +6% CER. The revenue distribution by region was 36%,
47% and 17% in the U.S., Europe and International
Operations, respectively. The largest markets are the U.S.,
Spain, Canada, Australia and Italy.