an increase of +47% CER (+31% DKK). Vyepti
®
maintained
its strong momentum across all regions. In the U.S.,
Vyepti
®
continued to grow in the first quarter of 2026,
maintaining its position as the fastest-growing anti-
calcitonin gene-related peptide (aCGRP) in the market,
reaching record-high 11.9% market share in February. The
growth was driven by an increase in new patient starts,
increased Vyepti Infusion Network enrolments,
prescription-to-fill conversion and high rates of
persistency with demand volume growing by +41.8% for
March 2026 year-to-date versus prior year. In Europe and
International Operations, Vyepti
®
maintained continued
growth momentum into the first quarter of 2026
delivering +55% CER growth compared to the same period
last year. Excluding the one-time revenue from inventory
build, growth in Europe was +44% CER and in International
Operations +45% CER. This was achieved through
continued strong demand growth across key markets,
with particularly strong momentum in France and Spain,
where Vyepti
®
demand (treatment days) outpaced
competitors, resulting in market shares of 68% (+6.5
percentage points compared to first quarter of 2025) in
France and 12% (+1.8 percentage points compared to the
first quarter of 2025) in Spain in February. The revenue
distribution by region was 86%, 10% and 4% in the U.S.,
Europe and International Operations, respectively. The
largest markets are the U.S., France, Canada, Spain and
Germany.
Brintellix
®
/Trintellix
®
(vortioxetine) revenue reached
DKK 1,296 million representing a growth of +8% CER (+3%
DKK). The one-time revenue from inventory build in
Partner Markets impacted the growth in the quarter.
Excluding this effect, the growth was -3% CER (-8% DKK).
Underlying growth in Europe continued with strong
double-digit growth, driven by France and Spain.
Performance remained pressured in International
Operations, and, in particular, in Canada following generic
entry in June 2025, and in China, where strong commercial
execution only partially offset post–volume-based
procurement (VBP) pressure. Selected markets showed
stronger momentum, notably Japan reaching 13% market
share (+1.0 percentage points compared to the first
quarter of 2025) in January. In Europe, Brintellix
®
continued to be an important growth brand. The slightly
softer momentum compared to previous quarters reflects
a combination of post-Q4 normalization following
relatively high prior-period sales, as well as lower
promotional intensity in the early part of the year,
specifically in Spain and Italy, both of which were timing
effects. Across key markets in Europe, the brand grew
+12% in treatment days compared to the first quarter of
2025. Excluding the one-time revenue from inventory
build, growth in Europe was +3% CER and in International
Operations -8% CER. In the U.S., Trintellix
®
reflects the
effect of the Takeda transition, effective 1 January 2025,
and is showing steady performance in line with
expectations for the transition. The revenue distribution
by region was 23%, 46% and 31% in the U.S., Europe and
International Operations, respectively. The largest
markets for this product are the U.S., Spain, Italy, Mexico
and France.
Abilify LAI franchise revenue reached DKK 1,033 million
and grew +8% CER (+2% DKK). The franchise delivered
solid growth in the first quarter of 2026. The Abilify LAI
franchise in the U.S. grew +8% CER in the first quarter of
2026, supported by +8.8% growth in demand volume
(rolling 3 months (R3M) February 2026 compared to prior
year). Strong growth in TRx volume for Abilify Asimtufii
®
(+39.2% R3M February 2026 compared to the same period
in 2025), and market share increased to 4.5% in February
as Lundbeck continues to source patients from oral
aripiprazole. Excluding the one-time revenue from
inventory build, revenue in Europe declined -1% CER while
revenue in International Operations grew +1% CER. The
year-on-year development in Europe was materially
distorted by prior-year gross-to-net comparator effects of
government-mandated rebates and paybacks in Italy
(AIFA) and the UK (VPAG). Adjusting for these effects,
underlying franchise development in Europe, excluding
revenue from inventory build, was +8% CER, in line with
previous quarters. This was supported by continued
uptake of Abilify Maintena
®
960 mg and encouraging
conversion from Abilify Maintena
®
, reaching 38% in Spain,
24% in France and 22% in Italy. Market research also
indicates that 25%-45% of patients are being switched
directly from oral atypical antipsychotics. Franchise growth
continued despite loss of exclusivity (LoE) as generic
competition has yet to enter the European markets. In
International Operations, Canada and Australia
experienced slightly accelerating growth despite LoE on
the back of expanding franchise market share leading to
37% market share in Australia (+1.3 percentage points
compared to the same period in 2025) and 39% market
share in Canada (+2.0 percentage points compared to the
same period in 2025) in February. Generally, the
conversion to Abilify Maintena
®
960 mg/Abilify Asimtufii
®
remains encouraging with sourcing from both other LAIs
and oral aripiprazole. The revenue distribution by region
was 34%, 50% and 16% in the U.S., Europe and
International Operations, respectively. The largest
markets are the U.S., Spain, Canada, Australia and Italy.