Gross profit
Cost of sales reached DKK 4,265 million increasing by
+3% CER (+1% DKK) mainly driven by costs related to a
manufacturing contract for amlenetug as well as an
environmental provision, partly offset by the reversal
of the Vyepti
®
provision for inventory obsolescence of
DKK 389 million, triggered by Vyepti
®
’s commercial
performance. In addition, lower amortization costs due
to fully amortized product rights also supported the
development. Excluding the extraordinary items, cost
of sales increased +9% DKK primarily impacted by the
one-time costs related to a manufacturing contract for
amlenetug and lower amortization costs.
Gross profit reached DKK 20,365 million, increasing by
+16% CER (+15% DKK). The gross margin was 82.7%
representing an increase of 1.9 percentage points.
Gross margin was mainly driven by a combination of
higher revenue, the reversal of the Vyepti
®
provision
for inventory obsolescence and lower amortization
costs, partially offset by costs related to a manufactur-
ing contract for amlenetug.
Adjusted gross profit is the gross profit excluding de-
preciation and amortization and other adjustments
linked to sales and cost of sales. The adjusted gross
margin was 87.5% representing a decrease of 0.9 per-
centage points primarily reflecting costs related to a
manufacturing contract for amlenetug.
EBIT and adjusted EBITDA
Total operating expenses (OPEX) reached DKK 15,090
million, corresponding to an increase of +13% CER
(+4% DKK). The OPEX ratio declined by 4.6 percentage
points to 61.3%. The development primarily reflects
the strong revenue growth and lower S&D ratio, par-
tially offset by higher R&D costs and the impact of
costs with the commercial restructuring and an impair-
ment loss regarding the planned divestment of a non-
core production site in Italy. Adjusted for the extraordi-
nary items in 2025 and 2024, OPEX ratio improved by
3.6 percentage points in 2025, largely driven by reve-
nue leverage, partially offset by higher R&D costs.
Sales and distribution costs reached DKK 7,743 mil-
lion, corresponding to a decrease of -2% CER (-5%
DKK). The S&D ratio decreased by 5.6 percentage
points to 31.4%, primarily reflecting leverage from the
strong revenue growth and improved cost efficiency.
The S&D ratio development reflects the successful exe-
cution of the Focused Innovator Strategy in 2025 in-
cluding the Trintellix
®
transition in the U.S., alongside
disciplined resource allocation and capital reallocation.
The resulting savings enabled continued investments
in strategic brands, particularly Rexulti
®
and Vyepti
®
in
the U.S., supporting sales force expansion and the
global roll-out of Vyepti
®
.
Administrative expenses reached DKK 1,483 million,
corresponding to a slight increase of +4% CER (+3%
DKK). The administrative expenses ratio decreased by
0.5 percentage points to 6.0%.
Research and development costs reached DKK 4,895
million, with an R&D ratio of 19.9%, increasing by +10%
CER (+9% DKK). The development in 2025 reflects the
continued commitment to innovation and was primar-
ily driven by advancing key pipeline programs, includ-
ing bexicaserin and amlenetug (anti-α-synuclein), as
well as ongoing progress in anti-ACTH and anti-PACAP
programs. In addition, in 2024, Lundbeck recognized
an impairment loss of DKK 547 million on part of the
carrying amount of one of the MAGLi projects follow-
ing a negative data read out from a phase I project.
Adjusted for the MAGLi impairment loss, R&D costs in-
creased +26% CER (+24% DKK), and R&D ratio in-
creased 1.9 percentage points.
Other operating expenses, net reached DKK 969 mil-
lion, increasing by +131% CER (+131% DKK), primarily
reflecting an impairment loss as part of the planned di-
vestment of a non-core production site in Italy and
commercial restructuring costs.
EBIT reached DKK 5,275 million, increasing by +59%
CER (+61% DKK) reflecting a combination of improved
gross profit driven by strong sales growth and lower
S&D ratio. This performance was partially offset by
higher R&D costs and higher other operating ex-
penses primarily driven by the commercial restructur-
ing announced in September 2025 and the impair-
ment loss from the planned divestment of a non-core
production site in Italy. EBIT growth was also impacted
by an impairment loss from one of the MAGLi projects
recognized in the third quarter of 2024.
Total amortization and depreciation amounted to
DKK 1,865 million (DKK 1,876 million in 2024). The de-
velopment was driven by higher amortizations costs
from an intangible asset recognized as part of the ac-
quisition of Longboard. In addition, the first quarter of
2024 was partially affected by costs associated with
fully amortized product rights of one product. Amorti-
zation of product rights amounted to DKK 1,294 mil-
lion, corresponding to a decrease of -8% CER (-10%
DKK). Amortization of other intangible assets corre-
sponded to DKK 189 million in 2025. Depreciation
amounted to DKK 382 million, corresponding to an in-
crease of +4% CER (+3% DKK).
Adjusted EBITDA reached DKK 7,881 million, repre-
senting an increase of +24% CER (+24% DKK) reflecting
the sales growth driven by strong performance of stra-
tegic brands, despite continued investments in build-
ing the R&D pipeline and the execution of the capital
reallocation program in line with the Focused Innova-
tor Strategy. The adjusted EBITDA margin increased
to 32.0% (28.8% in 2024), representing an increase of
3.2 percentage points.
Net profit and adjusted EPS
Net financial (income)/expenses amounted to an ex-
pense of DKK 788 million in 2025, primarily driven by
the higher interest costs of DKK 497 million due to
new debt obtained in connection with the acquisition