<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019daca3-5509-7cba-b647-2c41713bf7dd,g:94206d8d-5989-4b09-9e56-98d2fc171bd0-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel"/>
  <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
    <link:label id="lab_qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares_label_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Tax Witholding Related To Vesting Of Stock Awards, Equity, Shares</link:label>
    <link:label id="lab_qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares_documentation_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Tax Witholding Related To Vesting Of Stock Awards, Equity, Shares</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares" xlink:href="qgen-2025-12-31.xsd#qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares" xlink:to="lab_qgen_IncreaseDecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquityShares" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_StatementOfChangesInEquityAbstract_019daca3-55ee-78f4-a778-1e7f8002e018_terseLabel_en" xlink:label="lab_ifrs-full_StatementOfChangesInEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en">Statement of changes in equity placeholder - this item MUST be used as a starting point for the statement of changes in equity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityAbstract" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfChangesInEquityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract" xlink:to="lab_ifrs-full_StatementOfChangesInEquityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares_label_en" xlink:label="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Employee Stock Plans, Equity, Shares</link:label>
    <link:label id="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares_documentation_en" xlink:label="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Employee Stock Plans, Equity, Shares</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares" xlink:href="qgen-2025-12-31.xsd#qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares" xlink:to="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquityShares" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_StatementOfComprehensiveIncomeAbstract_019daca3-55ee-7050-b5d4-2c7b6d2e11aa_terseLabel_en" xlink:label="lab_ifrs-full_StatementOfComprehensiveIncomeAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en">Statement of comprehensive income placeholder - this item MUST be used as a starting point for the statement of comprehensive income if it is disclosed separately or when the statement of profit or loss and other comprehensive income statements are combined in a single statement</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfComprehensiveIncomeAbstract" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfComprehensiveIncomeAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_StatementOfComprehensiveIncomeAbstract" xlink:to="lab_ifrs-full_StatementOfComprehensiveIncomeAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_CostOfSales_019daca3-55ee-723a-a606-f0472de6f9d6_totalLabel_en" xlink:label="lab_ifrs-full_CostOfSales" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Cost of sales</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CostOfSales"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_CostOfSales" xlink:to="lab_ifrs-full_CostOfSales" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges_label_en" xlink:label="lab_qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Income Tax Relating To Reclassification Adjustments On Cash Flow Hedges</link:label>
    <link:label id="lab_qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges_documentation_en" xlink:label="lab_qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Income Tax Relating To Reclassification Adjustments On Cash Flow Hedges</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges" xlink:href="qgen-2025-12-31.xsd#qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges" xlink:to="lab_qgen_IncomeTaxRelatingToReclassificationAdjustmentsOnCashFlowHedges" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares_label_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Increase (decrease) through treasury share transactions, equity, shares</link:label>
    <link:label id="lab_qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares_documentation_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Increase (decrease) through treasury share transactions, equity, shares</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares" xlink:href="qgen-2025-12-31.xsd#qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares" xlink:to="lab_qgen_IncreaseDecreaseThroughTreasuryShareTransactionsEquityShares" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_CashFlowsFromUsedInFinancingActivities_019daca3-55ee-729a-89e8-7cf249355114_totalLabel_en" xlink:label="lab_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Cash flows from (used in) financing activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="lab_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities_label_en" xlink:label="lab_qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Adjustments for increase (decrease) in other noncurrent liabilities</link:label>
    <link:label id="lab_qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities_documentation_en" xlink:label="lab_qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Adjustments for increase (decrease) in other noncurrent liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities" xlink:href="qgen-2025-12-31.xsd#qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities" xlink:to="lab_qgen_AdjustmentsForIncreaseDecreaseInOtherNoncurrentLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_ProceedsFromPaymentsForCollateralLiability_label_en" xlink:label="lab_qgen_ProceedsFromPaymentsForCollateralLiability" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Proceeds From (Payments For) Collateral Liability</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_ProceedsFromPaymentsForCollateralLiability" xlink:href="qgen-2025-12-31.xsd#qgen_ProceedsFromPaymentsForCollateralLiability"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_ProceedsFromPaymentsForCollateralLiability" xlink:to="lab_qgen_ProceedsFromPaymentsForCollateralLiability" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_CashFlowsFromUsedInInvestingActivities_019daca3-55ee-7521-b4ab-54838fd69100_totalLabel_en" xlink:label="lab_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Cash flows from (used in) investing activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="lab_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_StatementOfCashFlowsAbstract_019daca3-55ee-7a0b-94f1-0b18b5653cab_terseLabel_en" xlink:label="lab_ifrs-full_StatementOfCashFlowsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en">Statement of cash flows placeholder - this item MUST be used as a starting point for the statement of cash flows</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfCashFlowsAbstract" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfCashFlowsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_StatementOfCashFlowsAbstract" xlink:to="lab_ifrs-full_StatementOfCashFlowsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_CostOfSalesExcludingDepreciationDepletionAndAmortization_label_en" xlink:label="lab_qgen_CostOfSalesExcludingDepreciationDepletionAndAmortization" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Cost Of Sales, Excluding Depreciation, Depletion And Amortization</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_CostOfSalesExcludingDepreciationDepletionAndAmortization" xlink:href="qgen-2025-12-31.xsd#qgen_CostOfSalesExcludingDepreciationDepletionAndAmortization"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_CostOfSalesExcludingDepreciationDepletionAndAmortization" xlink:to="lab_qgen_CostOfSalesExcludingDepreciationDepletionAndAmortization" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_StatementOfFinancialPositionAbstract_019daca3-55ee-735d-b670-2d021ac24e2d_terseLabel_en" xlink:label="lab_ifrs-full_StatementOfFinancialPositionAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en">Statement of financial position placeholder - this item MUST be used as a starting point for the statement of financial position</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfFinancialPositionAbstract" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_StatementOfFinancialPositionAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_StatementOfFinancialPositionAbstract" xlink:to="lab_ifrs-full_StatementOfFinancialPositionAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_RestructuringAcquisitionIntegrationAndOtherExpense_label_en" xlink:label="lab_qgen_RestructuringAcquisitionIntegrationAndOtherExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Restructuring, Acquisition, Integration And Other Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_RestructuringAcquisitionIntegrationAndOtherExpense" xlink:href="qgen-2025-12-31.xsd#qgen_RestructuringAcquisitionIntegrationAndOtherExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_RestructuringAcquisitionIntegrationAndOtherExpense" xlink:to="lab_qgen_RestructuringAcquisitionIntegrationAndOtherExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity_label_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Tax Benefit Of Employee Stock Plans, Equity</link:label>
    <link:label id="lab_qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity_documentation_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Decrease Through Tax Benefit Of Employee Stock Plans, Equity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity" xlink:href="qgen-2025-12-31.xsd#qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity" xlink:to="lab_qgen_IncreaseDecreaseThroughTaxBenefitOfEmployeeStockPlansEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_CashFlowsFromUsedInOperatingActivities_019daca3-55ee-7a59-8b93-cee4db331215_totalLabel_en" xlink:label="lab_ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Cash flows from (used in) operating activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:to="lab_ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_CostOfSalesDepreciationAmortizationAndDepletion_label_en" xlink:label="lab_qgen_CostOfSalesDepreciationAmortizationAndDepletion" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Cost Of Sales, Depreciation, Amortization And Depletion</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_CostOfSalesDepreciationAmortizationAndDepletion" xlink:href="qgen-2025-12-31.xsd#qgen_CostOfSalesDepreciationAmortizationAndDepletion"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_CostOfSalesDepreciationAmortizationAndDepletion" xlink:to="lab_qgen_CostOfSalesDepreciationAmortizationAndDepletion" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_OperatingExpenseExcludingCostOfSales_019daca3-55ee-72d4-af43-e5d0075d667b_totalLabel_en" xlink:label="lab_ifrs-full_OperatingExpenseExcludingCostOfSales" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Operating expense excluding cost of sales</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OperatingExpenseExcludingCostOfSales" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OperatingExpenseExcludingCostOfSales"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_OperatingExpenseExcludingCostOfSales" xlink:to="lab_ifrs-full_OperatingExpenseExcludingCostOfSales" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_FinanceIncomeCost_019daca3-55ee-731c-b7b4-008d3913d075_totalLabel_en" xlink:label="lab_ifrs-full_FinanceIncomeCost" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Finance income (cost)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_FinanceIncomeCost" xlink:to="lab_ifrs-full_FinanceIncomeCost" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts_label_en" xlink:label="lab_qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Adjustments For Other Decrease (Increase) In Financial Assets Measured At Amortized Costs</link:label>
    <link:label id="lab_qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts_documentation_en" xlink:label="lab_qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Adjustments For Other Decrease (Increase) In Financial Assets Measured At Amortized Costs</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts" xlink:href="qgen-2025-12-31.xsd#qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts" xlink:to="lab_qgen_AdjustmentsForOtherDecreaseIncreaseInFinancialAssetsMeasuredAtAmortizedCosts" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_019daca3-55ed-7d17-bfae-d928e2315595_totalLabel_en" xlink:label="lab_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Increase (decrease) in cash and cash equivalents</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents" xlink:to="lab_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_PaymentsForDerivativeInstruments_label_en" xlink:label="lab_qgen_PaymentsForDerivativeInstruments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Payments for derivative instruments</link:label>
    <link:label id="lab_qgen_PaymentsForDerivativeInstruments_documentation_en" xlink:label="lab_qgen_PaymentsForDerivativeInstruments" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Payments for derivative instruments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_PaymentsForDerivativeInstruments" xlink:href="qgen-2025-12-31.xsd#qgen_PaymentsForDerivativeInstruments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_PaymentsForDerivativeInstruments" xlink:to="lab_qgen_PaymentsForDerivativeInstruments" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards_label_en" xlink:label="lab_qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Payments For Tax Withholding Related To Vesting Of Stock Awards</link:label>
    <link:label id="lab_qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards_documentation_en" xlink:label="lab_qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Payments For Tax Withholding Related To Vesting Of Stock Awards</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards" xlink:href="qgen-2025-12-31.xsd#qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards" xlink:to="lab_qgen_PaymentsForTaxWithholdingRelatedToVestingOfStockAwards" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_PaymentsToShareholdersReturnOfCapital_label_en" xlink:label="lab_qgen_PaymentsToShareholdersReturnOfCapital" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Payments to shareholders, return of capital</link:label>
    <link:label id="lab_qgen_PaymentsToShareholdersReturnOfCapital_documentation_en" xlink:label="lab_qgen_PaymentsToShareholdersReturnOfCapital" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Payments to shareholders, return of capital</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_PaymentsToShareholdersReturnOfCapital" xlink:href="qgen-2025-12-31.xsd#qgen_PaymentsToShareholdersReturnOfCapital"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_PaymentsToShareholdersReturnOfCapital" xlink:to="lab_qgen_PaymentsToShareholdersReturnOfCapital" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_PaymentForContingentConsiderationFinancingActivity_label_en" xlink:label="lab_qgen_PaymentForContingentConsiderationFinancingActivity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Payment For Contingent Consideration, Financing Activity</link:label>
    <link:label id="lab_qgen_PaymentForContingentConsiderationFinancingActivity_documentation_en" xlink:label="lab_qgen_PaymentForContingentConsiderationFinancingActivity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Payment For Contingent Consideration, Financing Activity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_PaymentForContingentConsiderationFinancingActivity" xlink:href="qgen-2025-12-31.xsd#qgen_PaymentForContingentConsiderationFinancingActivity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_PaymentForContingentConsiderationFinancingActivity" xlink:to="lab_qgen_PaymentForContingentConsiderationFinancingActivity" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets_label_en" xlink:label="lab_qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Adjustments for decrease (increase) in other non-current assets</link:label>
    <link:label id="lab_qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets_documentation_en" xlink:label="lab_qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Adjustments for decrease (increase) in other non-current assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets" xlink:href="qgen-2025-12-31.xsd#qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets" xlink:to="lab_qgen_AdjustmentsForDecreaseIncreaseInOtherNonCurrentAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_ifrs-full_GrossProfit_019daca3-55ee-76a7-a9c2-79413eb184aa_totalLabel_en" xlink:label="lab_ifrs-full_GrossProfit" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en">Gross profit</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GrossProfit" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GrossProfit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_ifrs-full_GrossProfit" xlink:to="lab_ifrs-full_GrossProfit" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment_label_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Transactions With Owners, Equity, Capital Repayment</link:label>
    <link:label id="lab_qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment_documentation_en" xlink:label="lab_qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Transactions With Owners, Equity, Capital Repayment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment" xlink:href="qgen-2025-12-31.xsd#qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment" xlink:to="lab_qgen_IncreaseDecreaseThroughTransactionsWithOwnersEquityCapitalRepayment" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity_label_en" xlink:label="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Employee Stock Plans, Equity</link:label>
    <link:label id="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity_documentation_en" xlink:label="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en"></link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity" xlink:href="qgen-2025-12-31.xsd#qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity" xlink:to="lab_qgen_IncreaseDecreaseThroughEmployeeStockPlansEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity_label_en" xlink:label="lab_qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Decrease Through Tax Witholding Related To Vesting Of Stock Awards, Equity</link:label>
    <link:label id="lab_qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity_documentation_en" xlink:label="lab_qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en"></link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity" xlink:href="qgen-2025-12-31.xsd#qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity" xlink:to="lab_qgen_DecreaseThroughTaxWitholdingRelatedToVestingOfStockAwardsEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity_label_en" xlink:label="lab_qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Share-Based Payments Transactions, Equity</link:label>
    <link:label id="lab_qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity_documentation_en" xlink:label="lab_qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Increase (Decrease) Through Share-Based Payments Transactions, Equity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity" xlink:href="qgen-2025-12-31.xsd#qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity" xlink:to="lab_qgen_IncreaseDecreaseThroughShareBasedPaymentsTransactionsEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives_label_en" xlink:label="lab_qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Other Adjustments For Changes In Operating Activities Including Fair Value Changes In Derivatives</link:label>
    <link:label id="lab_qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives_documentation_en" xlink:label="lab_qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Other Adjustments For Changes In Operating Activities Including Fair Value Changes In Derivatives</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives" xlink:href="qgen-2025-12-31.xsd#qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives" xlink:to="lab_qgen_OtherAdjustmentsForChangesInOperatingActivitiesIncludingFairValueChangesInDerivatives" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_IncomeTaxOnCashFlowHedgesGainsLosses_label_en" xlink:label="lab_qgen_IncomeTaxOnCashFlowHedgesGainsLosses" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Income Tax On Cash Flow Hedges Gains (Losses)</link:label>
    <link:label id="lab_qgen_IncomeTaxOnCashFlowHedgesGainsLosses_documentation_en" xlink:label="lab_qgen_IncomeTaxOnCashFlowHedgesGainsLosses" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Income Tax On Cash Flow Hedges Gains (Losses)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_IncomeTaxOnCashFlowHedgesGainsLosses" xlink:href="qgen-2025-12-31.xsd#qgen_IncomeTaxOnCashFlowHedgesGainsLosses"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_IncomeTaxOnCashFlowHedgesGainsLosses" xlink:to="lab_qgen_IncomeTaxOnCashFlowHedgesGainsLosses" xlink:type="arc" order="1"/>
    <link:label id="lab_qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts_label_en" xlink:label="lab_qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en">Adjustments for amortisation of debt discount and debt issue costs</link:label>
    <link:label id="lab_qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts_documentation_en" xlink:label="lab_qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en">Adjustments for amortisation of debt discount and debt issue costs</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts" xlink:href="qgen-2025-12-31.xsd#qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts" xlink:to="lab_qgen_AdjustmentsForAmortisationOfDebtDiscountAndDebtIssueCosts" xlink:type="arc" order="1"/>
  </link:labelLink>
</link:linkbase>
