<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:4f949eb5-5c47-4cfa-9d77-5063293e09a8,g:3661ee82-8618-4ba7-997c-914548357483-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.gsk.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseDetails" xlink:type="simple" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseDetails"/>
  <link:calculationLink xlink:role="http://www.gsk.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_e8581579-a770-49ff-99e4-12c53c3539b0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_8c5b3cfa-595f-44ee-a18f-fcd9c0b27b7c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_e8581579-a770-49ff-99e4-12c53c3539b0" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_8c5b3cfa-595f-44ee-a18f-fcd9c0b27b7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_05c64adb-b8bb-4563-bc7f-009e05917865" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_e8581579-a770-49ff-99e4-12c53c3539b0" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_05c64adb-b8bb-4563-bc7f-009e05917865" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_1895ae4d-a4e8-451f-8bb0-fe3405820832" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_aa740103-5ca1-4bd7-ad65-dc51e30b61ac" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_1895ae4d-a4e8-451f-8bb0-fe3405820832" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_aa740103-5ca1-4bd7-ad65-dc51e30b61ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_3f91b517-9cf9-4504-8b97-d98b78e47da5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_1895ae4d-a4e8-451f-8bb0-fe3405820832" xlink:to="loc_ifrs-full_FinanceIncome_3f91b517-9cf9-4504-8b97-d98b78e47da5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_3329df13-80da-41dc-9f6c-63e377c58618" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_1895ae4d-a4e8-451f-8bb0-fe3405820832" xlink:to="loc_ifrs-full_FinanceCosts_3329df13-80da-41dc-9f6c-63e377c58618" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_cfb899b7-89e1-48cf-b2bc-a6bf9737d3cc" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_1895ae4d-a4e8-451f-8bb0-fe3405820832" xlink:to="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_cfb899b7-89e1-48cf-b2bc-a6bf9737d3cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnDisposalsOfInvestments_019b7f1e-ce2d-7ea3-8a52-deffdc5b2ef8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnDisposalsOfInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_1895ae4d-a4e8-451f-8bb0-fe3405820832" xlink:to="loc_ifrs-full_GainsLossesOnDisposalsOfInvestments_019b7f1e-ce2d-7ea3-8a52-deffdc5b2ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_00c32251-ee12-45e1-bdc6-d9c769483342" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromRoyalties_2cb094ba-60ea-4c7a-95ec-9690e8d2a545" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RevenueFromRoyalties"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_00c32251-ee12-45e1-bdc6-d9c769483342" xlink:to="loc_ifrs-full_RevenueFromRoyalties_2cb094ba-60ea-4c7a-95ec-9690e8d2a545" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_5280664c-ff14-49dc-a6da-5614db275749" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_00c32251-ee12-45e1-bdc6-d9c769483342" xlink:to="loc_ifrs-full_OtherOperatingIncomeExpense_5280664c-ff14-49dc-a6da-5614db275749" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_88898e64-25bc-43a0-adcf-ee6c5916f934" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_00c32251-ee12-45e1-bdc6-d9c769483342" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_88898e64-25bc-43a0-adcf-ee6c5916f934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GrossProfit_90b6d9a9-2ff9-4440-bf8d-189928aaa0ed" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GrossProfit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_00c32251-ee12-45e1-bdc6-d9c769483342" xlink:to="loc_ifrs-full_GrossProfit_90b6d9a9-2ff9-4440-bf8d-189928aaa0ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_ffa3fff7-ff20-43a9-8009-771c494c8c3a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_00c32251-ee12-45e1-bdc6-d9c769483342" xlink:to="loc_ifrs-full_SellingGeneralAndAdministrativeExpense_ffa3fff7-ff20-43a9-8009-771c494c8c3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GrossProfit_8dc47a8a-de31-412d-bf84-b247a05ae394" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromSaleOfGoods_c24abba3-13d1-4a42-9bf1-6e64c30fce74" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RevenueFromSaleOfGoods"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_GrossProfit_8dc47a8a-de31-412d-bf84-b247a05ae394" xlink:to="loc_ifrs-full_RevenueFromSaleOfGoods_c24abba3-13d1-4a42-9bf1-6e64c30fce74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CostOfSales_5cade293-ab5c-448e-a32f-522ca7a6abcd" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CostOfSales"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_GrossProfit_8dc47a8a-de31-412d-bf84-b247a05ae394" xlink:to="loc_ifrs-full_CostOfSales_5cade293-ab5c-448e-a32f-522ca7a6abcd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.gsk.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseDetails_1" xlink:type="simple" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseDetails_1"/>
  <link:calculationLink xlink:role="http://www.gsk.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_398ccf49-e55b-43af-8a88-06e5773ea6d4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_0201919b-c78d-44f0-bef6-24f9330f391e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_398ccf49-e55b-43af-8a88-06e5773ea6d4" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_0201919b-c78d-44f0-bef6-24f9330f391e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_5cb0a70c-010b-41bc-8421-657919c4666b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_398ccf49-e55b-43af-8a88-06e5773ea6d4" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_5cb0a70c-010b-41bc-8421-657919c4666b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.gsk.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxDetails" xlink:type="simple" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxDetails"/>
  <link:calculationLink xlink:role="http://www.gsk.com/role/StatementofcomprehensiveincomeOCIcomponentspresentednetoftaxDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_62ee26e2-539e-4c78-adab-19b03a78cbdd" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToInvestmentsInEquityInstrumentsOfOtherComprehensiveIncome_83d90bf8-3ad5-4f49-aa71-0c6b40f99d0b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxRelatingToInvestmentsInEquityInstrumentsOfOtherComprehensiveIncome"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_62ee26e2-539e-4c78-adab-19b03a78cbdd" xlink:to="loc_ifrs-full_IncomeTaxRelatingToInvestmentsInEquityInstrumentsOfOtherComprehensiveIncome_83d90bf8-3ad5-4f49-aa71-0c6b40f99d0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments_66efe27b-952e-4bb9-8965-7235e4d3b32c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_62ee26e2-539e-4c78-adab-19b03a78cbdd" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments_66efe27b-952e-4bb9-8965-7235e4d3b32c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_FairValueMovementsOnCashFlowHedgesNotReclassified_f59e141c-016d-438a-8d43-ecbeb6557621" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_FairValueMovementsOnCashFlowHedgesNotReclassified"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_62ee26e2-539e-4c78-adab-19b03a78cbdd" xlink:to="loc_gsk_FairValueMovementsOnCashFlowHedgesNotReclassified_f59e141c-016d-438a-8d43-ecbeb6557621" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_efeece7e-f42a-4021-a669-3ce60085fe84" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_62ee26e2-539e-4c78-adab-19b03a78cbdd" xlink:to="loc_ifrs-full_IncomeTaxRelatingToRemeasurementsOfDefinedBenefitPlansOfOtherComprehensiveIncome_efeece7e-f42a-4021-a669-3ce60085fe84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_ExchangeMovementsOnOverseasNetAssetsOfNonControllingInterests_923f4986-aedc-45cc-8706-22b0238a617e" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_ExchangeMovementsOnOverseasNetAssetsOfNonControllingInterests"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_62ee26e2-539e-4c78-adab-19b03a78cbdd" xlink:to="loc_gsk_ExchangeMovementsOnOverseasNetAssetsOfNonControllingInterests_923f4986-aedc-45cc-8706-22b0238a617e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_d6f0b370-98c8-492d-b655-891d51536571" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_62ee26e2-539e-4c78-adab-19b03a78cbdd" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesOnRemeasurementsOfDefinedBenefitPlans_d6f0b370-98c8-492d-b655-891d51536571" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_d6ccde04-ed99-4d3b-af6d-4add463dd228" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_b0172eab-a565-427f-be7a-a565a957aea2" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_d6ccde04-ed99-4d3b-af6d-4add463dd228" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillNotBeReclassifiedToProfitOrLossNetOfTax_b0172eab-a565-427f-be7a-a565a957aea2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_54ace7a8-7cdf-4e6a-bdf9-01d95b0aac09" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_d6ccde04-ed99-4d3b-af6d-4add463dd228" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_54ace7a8-7cdf-4e6a-bdf9-01d95b0aac09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_0190f712-66ba-4b0b-90a8-891ee1c92997" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesNetOfTax_018402cd-1c7b-43d1-87bf-73d50449ae99" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesNetOfTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_0190f712-66ba-4b0b-90a8-891ee1c92997" xlink:to="loc_ifrs-full_ReclassificationAdjustmentsOnCashFlowHedgesNetOfTax_018402cd-1c7b-43d1-87bf-73d50449ae99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_ExchangeDifferencesOnTranslationOfForeignOperationsAndHedgesOfNetInvestmentsInForeignOperations_ec9ef723-7127-4e29-a3c0-aee7af3d64a7" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_ExchangeDifferencesOnTranslationOfForeignOperationsAndHedgesOfNetInvestmentsInForeignOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_0190f712-66ba-4b0b-90a8-891ee1c92997" xlink:to="loc_gsk_ExchangeDifferencesOnTranslationOfForeignOperationsAndHedgesOfNetInvestmentsInForeignOperations_ec9ef723-7127-4e29-a3c0-aee7af3d64a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnChangeInValueOfTimeValueOfOptionsNetOfTax_cbbe6ca5-c432-433d-a11d-493d2a619dcd" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnChangeInValueOfTimeValueOfOptionsNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_0190f712-66ba-4b0b-90a8-891ee1c92997" xlink:to="loc_ifrs-full_GainsLossesOnChangeInValueOfTimeValueOfOptionsNetOfTax_cbbe6ca5-c432-433d-a11d-493d2a619dcd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome_0c953959-2f2a-49fa-b71f-d80011c595fc" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_0190f712-66ba-4b0b-90a8-891ee1c92997" xlink:to="loc_ifrs-full_IncomeTaxRelatingToCashFlowHedgesOfOtherComprehensiveIncome_0c953959-2f2a-49fa-b71f-d80011c595fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_ReclassificationAdjustmentOfNetExchangeDifferencesOnDisposalOfForeignOperations_52bd7f80-706d-47d1-bd7b-108ea82729e4" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_ReclassificationAdjustmentOfNetExchangeDifferencesOnDisposalOfForeignOperations"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_0190f712-66ba-4b0b-90a8-891ee1c92997" xlink:to="loc_gsk_ReclassificationAdjustmentOfNetExchangeDifferencesOnDisposalOfForeignOperations_52bd7f80-706d-47d1-bd7b-108ea82729e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_0b3d182d-c0cd-4d1d-8a43-e879ac6fe5f5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncomeThatWillBeReclassifiedToProfitOrLossNetOfTax_0190f712-66ba-4b0b-90a8-891ee1c92997" xlink:to="loc_ifrs-full_GainsLossesOnCashFlowHedgesBeforeTax_0b3d182d-c0cd-4d1d-8a43-e879ac6fe5f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_84ed9ab9-002d-4339-87a6-c76b121bf63e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_994f18be-913b-4297-b967-0d2392fd177c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_84ed9ab9-002d-4339-87a6-c76b121bf63e" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_994f18be-913b-4297-b967-0d2392fd177c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_103d9e1a-70b9-4060-b012-427208668931" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_84ed9ab9-002d-4339-87a6-c76b121bf63e" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_103d9e1a-70b9-4060-b012-427208668931" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.gsk.com/role/StatementoffinancialpositioncurrentnoncurrentDetails" xlink:type="simple" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#StatementoffinancialpositioncurrentnoncurrentDetails"/>
  <link:calculationLink xlink:role="http://www.gsk.com/role/StatementoffinancialpositioncurrentnoncurrentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_beda1b6f-02aa-4b64-8dbe-a1b73416cdd8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_beda1b6f-02aa-4b64-8dbe-a1b73416cdd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_LiquidInvestments_eb034745-57f2-4028-86c5-8eac0cffdb80" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_LiquidInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:to="loc_gsk_LiquidInvestments_eb034745-57f2-4028-86c5-8eac0cffdb80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_19c9a6a2-bae2-40ce-8f1f-9364ef4b45cf" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:to="loc_ifrs-full_CashAndCashEquivalents_19c9a6a2-bae2-40ce-8f1f-9364ef4b45cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_733e80ce-8196-4869-b982-68df0e13b9a7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:to="loc_ifrs-full_NoncurrentAssetsOrDisposalGroupsClassifiedAsHeldForSale_733e80ce-8196-4869-b982-68df0e13b9a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssets_955c101b-cd07-4ba7-8f05-9333ba71806e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:to="loc_ifrs-full_CurrentTaxAssets_955c101b-cd07-4ba7-8f05-9333ba71806e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDerivativeFinancialAssets_5e6ba930-1c77-48da-8079-19b2dd61364c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentDerivativeFinancialAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:to="loc_ifrs-full_CurrentDerivativeFinancialAssets_5e6ba930-1c77-48da-8079-19b2dd61364c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Inventories_5f82396d-273f-49e5-8e45-58864c512f51" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Inventories"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_7f54333f-f2ad-4cd0-98a6-2012dad79591" xlink:to="loc_ifrs-full_Inventories_5f82396d-273f-49e5-8e45-58864c512f51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShorttermBorrowings_d32ae24f-5783-4785-afe5-99646d7fa87e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ShorttermBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:to="loc_ifrs-full_ShorttermBorrowings_d32ae24f-5783-4785-afe5-99646d7fa87e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_ContingentConsiderationLiabilities_a2db1a4f-2f05-46ed-99ec-4f49cc8eb11d" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_ContingentConsiderationLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:to="loc_gsk_ContingentConsiderationLiabilities_a2db1a4f-2f05-46ed-99ec-4f49cc8eb11d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_04615a7c-77e4-4ac8-81d4-59a491c0bb5c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_04615a7c-77e4-4ac8-81d4-59a491c0bb5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_1a632070-73c1-407e-9a9c-b07db6ba0820" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentDerivativeFinancialLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:to="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_1a632070-73c1-407e-9a9c-b07db6ba0820" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxLiabilities_0de68539-ddae-4e5d-ab38-a677b0d043e1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentTaxLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:to="loc_ifrs-full_CurrentTaxLiabilities_0de68539-ddae-4e5d-ab38-a677b0d043e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherShorttermProvisions_92b54e3a-3955-48b8-a48e-1360328ab059" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherShorttermProvisions"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:to="loc_ifrs-full_OtherShorttermProvisions_92b54e3a-3955-48b8-a48e-1360328ab059" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale_019c32b3-dc9f-7067-8901-d1006a723c9f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_75cb9ce3-6da6-4f99-a4bc-6c8cfca993c4" xlink:to="loc_ifrs-full_LiabilitiesIncludedInDisposalGroupsClassifiedAsHeldForSale_019c32b3-dc9f-7067-8901-d1006a723c9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_51d0e21c-be0e-4291-bf4e-36567cea53a0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_51d0e21c-be0e-4291-bf4e-36567cea53a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxAssets_fd8f9abc-729d-47b7-b849-4d9ec1c54ae9" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_DeferredTaxAssets_fd8f9abc-729d-47b7-b849-4d9ec1c54ae9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_a16ee6ea-1003-47b8-b8a1-a0824df5a003" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_NoncurrentInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_a16ee6ea-1003-47b8-b8a1-a0824df5a003" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_3f86eef5-9c15-4d4f-93d8-cca53da398e0" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_3f86eef5-9c15-4d4f-93d8-cca53da398e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_75d5eea2-f38f-41ad-9ecd-6073aaf5d4a6" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_75d5eea2-f38f-41ad-9ecd-6073aaf5d4a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_a6159421-3760-4d12-b015-8404a8c75a8f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InvestmentAccountedForUsingEquityMethod"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_InvestmentAccountedForUsingEquityMethod_a6159421-3760-4d12-b015-8404a8c75a8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Goodwill_7f10d009-3c8c-47df-9c76-456af5f66977" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Goodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_Goodwill_7f10d009-3c8c-47df-9c76-456af5f66977" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_84d38d93-23d0-4f99-b827-f8e8e78f9f01" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RightofuseAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_RightofuseAssets_84d38d93-23d0-4f99-b827-f8e8e78f9f01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentDerivativeFinancialAssets_1901da69-fa04-4731-857c-81cfc1370bab" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentDerivativeFinancialAssets"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_ec051ad4-d867-4336-ae3c-c9c41cfb653e" xlink:to="loc_ifrs-full_NoncurrentDerivativeFinancialAssets_1901da69-fa04-4731-857c-81cfc1370bab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetAssetsLiabilities_a049fbfe-a3c6-448f-9562-257e673d5d58" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NetAssetsLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_2546f62d-3958-44f0-a1e2-9c78c8f84c1b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Assets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NetAssetsLiabilities_a049fbfe-a3c6-448f-9562-257e673d5d58" xlink:to="loc_ifrs-full_Assets_2546f62d-3958-44f0-a1e2-9c78c8f84c1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_b48453d3-8366-42f0-a686-a64b58161f1a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NetAssetsLiabilities_a049fbfe-a3c6-448f-9562-257e673d5d58" xlink:to="loc_ifrs-full_Liabilities_b48453d3-8366-42f0-a686-a64b58161f1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_9914196d-8c45-4b22-a8fe-25e39a19a638" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_d9137060-792b-484d-a217-5e0c59b67011" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_9914196d-8c45-4b22-a8fe-25e39a19a638" xlink:to="loc_ifrs-full_OtherReserves_d9137060-792b-484d-a217-5e0c59b67011" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_9929a2d0-78ed-454b-8738-0620d5325c4d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_9914196d-8c45-4b22-a8fe-25e39a19a638" xlink:to="loc_ifrs-full_IssuedCapital_9929a2d0-78ed-454b-8738-0620d5325c4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_b743a36f-34f4-41d5-8b30-4a872254e1b5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RetainedEarnings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_9914196d-8c45-4b22-a8fe-25e39a19a638" xlink:to="loc_ifrs-full_RetainedEarnings_b743a36f-34f4-41d5-8b30-4a872254e1b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_dc1c417c-14a5-4896-9046-b5c3a75e1973" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_SharePremium"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_9914196d-8c45-4b22-a8fe-25e39a19a638" xlink:to="loc_ifrs-full_SharePremium_dc1c417c-14a5-4896-9046-b5c3a75e1973" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_e865a249-6eda-4208-8888-e7da36aa9c8d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_17ac96b7-787c-4f41-997b-e2a46cfd39f1" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_e865a249-6eda-4208-8888-e7da36aa9c8d" xlink:to="loc_ifrs-full_NoncurrentLiabilities_17ac96b7-787c-4f41-997b-e2a46cfd39f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_788fe30e-f824-4fbf-ad50-70dd3959f09c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_e865a249-6eda-4208-8888-e7da36aa9c8d" xlink:to="loc_ifrs-full_CurrentLiabilities_788fe30e-f824-4fbf-ad50-70dd3959f09c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_90e10ef5-64f1-4d61-b43d-1cf16b4d9050" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_ffeb2448-3cde-4d3f-ae90-deb0dc2445e7" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_90e10ef5-64f1-4d61-b43d-1cf16b4d9050" xlink:to="loc_ifrs-full_CurrentAssets_ffeb2448-3cde-4d3f-ae90-deb0dc2445e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_0f31ae6d-0082-4b9c-b93c-ab4e3ac1a88e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_90e10ef5-64f1-4d61-b43d-1cf16b4d9050" xlink:to="loc_ifrs-full_NoncurrentAssets_0f31ae6d-0082-4b9c-b93c-ab4e3ac1a88e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LongtermBorrowings_89aba091-2ce8-4a68-a818-d7058c65422f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_LongtermBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:to="loc_ifrs-full_LongtermBorrowings_89aba091-2ce8-4a68-a818-d7058c65422f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_c75b08f2-5757-4e97-a5e4-a42578d2b17f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_c75b08f2-5757-4e97-a5e4-a42578d2b17f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_e9f4b736-d633-4d8a-842a-6c7937062481" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentProvisionsForEmployeeBenefits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:to="loc_ifrs-full_NoncurrentProvisionsForEmployeeBenefits_e9f4b736-d633-4d8a-842a-6c7937062481" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentDerivativeFinancialLiabilities_92baed71-b81e-498f-8425-97bdd61c4026" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentDerivativeFinancialLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:to="loc_ifrs-full_NoncurrentDerivativeFinancialLiabilities_92baed71-b81e-498f-8425-97bdd61c4026" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherLongtermProvisions_2c8aec49-956f-4286-810d-110341c8b762" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherLongtermProvisions"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:to="loc_ifrs-full_OtherLongtermProvisions_2c8aec49-956f-4286-810d-110341c8b762" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialLiabilitiesAtFairValueThroughProfitOrLoss_b7abf3e2-e998-4f10-bb94-f145dd26a97e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncurrentFinancialLiabilitiesAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:to="loc_ifrs-full_NoncurrentFinancialLiabilitiesAtFairValueThroughProfitOrLoss_b7abf3e2-e998-4f10-bb94-f145dd26a97e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentLiabilities_019c32b4-0fe7-7ae4-bb4e-0f53df29a0a5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherNoncurrentLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_148250c6-4989-4ba1-9cd0-5a9fd3e1662c" xlink:to="loc_ifrs-full_OtherNoncurrentLiabilities_019c32b4-0fe7-7ae4-bb4e-0f53df29a0a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_38a8b293-c1f4-4f15-9ebd-940213d1bd5e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_70c065c9-5377-482b-b189-b1482411e70d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_38a8b293-c1f4-4f15-9ebd-940213d1bd5e" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_70c065c9-5377-482b-b189-b1482411e70d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_868fa013-6af8-4bbd-835e-850c3bc7d214" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_38a8b293-c1f4-4f15-9ebd-940213d1bd5e" xlink:to="loc_ifrs-full_NoncontrollingInterests_868fa013-6af8-4bbd-835e-850c3bc7d214" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.gsk.com/role/StatementofchangesinequityDetails" xlink:type="simple" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#StatementofchangesinequityDetails"/>
  <link:calculationLink xlink:role="http://www.gsk.com/role/StatementofchangesinequityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_1ca69a4d-e887-4b05-9359-abff206ca472" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_669f575f-f5f6-4a1f-b3df-d1ccee1749b9" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_1ca69a4d-e887-4b05-9359-abff206ca472" xlink:to="loc_ifrs-full_ProfitLoss_669f575f-f5f6-4a1f-b3df-d1ccee1749b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_01749cff-957d-4ffa-8b85-856dd4810ca4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_1ca69a4d-e887-4b05-9359-abff206ca472" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_01749cff-957d-4ffa-8b85-856dd4810ca4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.gsk.com/role/StatementofcashflowsindirectmethodDetails" xlink:type="simple" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#StatementofcashflowsindirectmethodDetails"/>
  <link:calculationLink xlink:role="http://www.gsk.com/role/StatementofcashflowsindirectmethodDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_b642593e-cbc6-4c55-9e8f-4b44490152ba" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_e5b8ddd3-5bbc-4e22-a0aa-45fe693e511f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_b642593e-cbc6-4c55-9e8f-4b44490152ba" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_e5b8ddd3-5bbc-4e22-a0aa-45fe693e511f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_12b73f94-39b1-4b89-9f42-4b859e310324" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_b642593e-cbc6-4c55-9e8f-4b44490152ba" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_12b73f94-39b1-4b89-9f42-4b859e310324" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a97498ff-923c-48fa-ba19-a92a68c66962" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_b642593e-cbc6-4c55-9e8f-4b44490152ba" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_a97498ff-923c-48fa-ba19-a92a68c66962" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_b7a11ba7-0a63-4d5e-9763-54b96c8acc99" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_b7a11ba7-0a63-4d5e-9763-54b96c8acc99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_64059ff2-5fa4-422d-8ddc-1e8211586300" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_64059ff2-5fa4-422d-8ddc-1e8211586300" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_6edc7225-620f-451a-b5fe-cdf558f2ab3b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_6edc7225-620f-451a-b5fe-cdf558f2ab3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfIntangibleAssetsClassifiedAsInvestingActivities_9fc3a596-e945-40b8-a1d3-aaaf3aa2fe60" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromSalesOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_ProceedsFromSalesOfIntangibleAssetsClassifiedAsInvestingActivities_9fc3a596-e945-40b8-a1d3-aaaf3aa2fe60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_IncreaseDecreaseInLiquidInvestments_d5a8b6ec-7fba-49df-a281-fc56443553df" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_IncreaseDecreaseInLiquidInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_gsk_IncreaseDecreaseInLiquidInvestments_d5a8b6ec-7fba-49df-a281-fc56443553df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_7a3adbfc-eef6-4a87-b248-e17c94cb58ba" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_7a3adbfc-eef6-4a87-b248-e17c94cb58ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_65defabc-4668-466e-a04f-ba0898ab59a8" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_CashFlowsUsedInObtainingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_65defabc-4668-466e-a04f-ba0898ab59a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_cde425dd-5919-4f1e-93e1-ed94bdcb7cdc" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_cde425dd-5919-4f1e-93e1-ed94bdcb7cdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_CashInflowsOutflowsFromShareTransactionsWithNonControllingInterests_b2396f77-b79c-4f87-a31a-cfd8269dcf03" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_CashInflowsOutflowsFromShareTransactionsWithNonControllingInterests"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_gsk_CashInflowsOutflowsFromShareTransactionsWithNonControllingInterests_b2396f77-b79c-4f87-a31a-cfd8269dcf03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_OutflowOfCashThroughCCLClassifiedAsInvestingActivities_405cf005-1248-428b-9835-3e72bb73a5ba" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_OutflowOfCashThroughCCLClassifiedAsInvestingActivities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_gsk_OutflowOfCashThroughCCLClassifiedAsInvestingActivities_405cf005-1248-428b-9835-3e72bb73a5ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_34a8d970-df0d-4539-9d49-d3c505098f96" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_34a8d970-df0d-4539-9d49-d3c505098f96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfInterestsInInvestmentsAccountedForUsingEquityMethod_bbdcf71d-a031-4ff5-b9d8-6150115e6f4e" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PurchaseOfInterestsInInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_PurchaseOfInterestsInInvestmentsAccountedForUsingEquityMethod_bbdcf71d-a031-4ff5-b9d8-6150115e6f4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfInvestmentsAccountedForUsingEquityMethod_3682ad69-0bad-472e-b816-ed127724e573" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromSalesOfInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_ProceedsFromSalesOfInvestmentsAccountedForUsingEquityMethod_3682ad69-0bad-472e-b816-ed127724e573" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsInvestingActivities_c1ff60dc-3163-4c1b-a3bc-392a4e285e7d" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestReceivedClassifiedAsInvestingActivities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsInvestingActivities_c1ff60dc-3163-4c1b-a3bc-392a4e285e7d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_DividendsAndDistributionsReceivedClassifiedAsInvestingActivities_0c9e5d51-a83a-4af9-8203-acba88cc4cdb" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_DividendsAndDistributionsReceivedClassifiedAsInvestingActivities"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_gsk_DividendsAndDistributionsReceivedClassifiedAsInvestingActivities_0c9e5d51-a83a-4af9-8203-acba88cc4cdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsReceivedFromInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities_35309324-d6bf-4d51-bf52-32fedc3d1b4a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsReceivedFromInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_7f789280-a15f-4d9c-acc8-08b408cea66d" xlink:to="loc_ifrs-full_DividendsReceivedFromInvestmentsAccountedForUsingEquityMethodClassifiedAsInvestingActivities_35309324-d6bf-4d51-bf52-32fedc3d1b4a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalentsIfDifferentFromStatementOfFinancialPosition_2343ca58-9e1e-4496-8447-a01aa1bc218f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalentsIfDifferentFromStatementOfFinancialPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_36978638-50db-4a7a-9ada-77ec86eef1c4" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalentsIfDifferentFromStatementOfFinancialPosition_2343ca58-9e1e-4496-8447-a01aa1bc218f" xlink:to="loc_ifrs-full_CashAndCashEquivalents_36978638-50db-4a7a-9ada-77ec86eef1c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BankOverdraftsClassifiedAsCashEquivalents_f460dd18-67f5-4910-8dac-45f4b917172b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_BankOverdraftsClassifiedAsCashEquivalents"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashAndCashEquivalentsIfDifferentFromStatementOfFinancialPosition_2343ca58-9e1e-4496-8447-a01aa1bc218f" xlink:to="loc_ifrs-full_BankOverdraftsClassifiedAsCashEquivalents_f460dd18-67f5-4910-8dac-45f4b917172b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019b8dcc-cda8-79a7-90d2-1e9e7dbda533" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperations_019b8dcc-cda8-7ae5-9075-42d223d6c25a" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019b8dcc-cda8-79a7-90d2-1e9e7dbda533" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperations_019b8dcc-cda8-7ae5-9075-42d223d6c25a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_019b8dcc-cda8-721e-b261-9298089d6487" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_019b8dcc-cda8-79a7-90d2-1e9e7dbda533" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_019b8dcc-cda8-721e-b261-9298089d6487" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssuingShares_29be3c34-82db-4c0f-b7ec-314b25c60ca3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromIssuingShares"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_ProceedsFromIssuingShares_29be3c34-82db-4c0f-b7ec-314b25c60ca3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_158d28c7-1dcf-444c-9895-eedc15bc45e5" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_RepaymentsOfNoncurrentBorrowings"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_158d28c7-1dcf-444c-9895-eedc15bc45e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_c5cb8368-45bd-4a93-a6ad-23975fa66eab" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromNoncurrentBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_c5cb8368-45bd-4a93-a6ad-23975fa66eab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_ProceedsRepaymentsFromOfShortTermLoans_9fcac8cd-8468-4117-8489-c533022d782a" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_ProceedsRepaymentsFromOfShortTermLoans"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_gsk_ProceedsRepaymentsFromOfShortTermLoans_9fcac8cd-8468-4117-8489-c533022d782a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_IncreaseDecreaseInOtherShortTermLoans_86c7ee85-b349-4004-8bbc-8d4ee27effe7" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_IncreaseDecreaseInOtherShortTermLoans"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_gsk_IncreaseDecreaseInOtherShortTermLoans_86c7ee85-b349-4004-8bbc-8d4ee27effe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_RepaymentOfOtherShortTermLoans_c04c5118-fb5f-4878-8c03-178dae50a241" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_RepaymentOfOtherShortTermLoans"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_gsk_RepaymentOfOtherShortTermLoans_c04c5118-fb5f-4878-8c03-178dae50a241" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_74431b8b-0e2d-452f-b129-087fbe2ac7f3" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_74431b8b-0e2d-452f-b129-087fbe2ac7f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_219d783b-be77-45ba-b238-596dfca39431" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_InterestPaidClassifiedAsFinancingActivities"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsFinancingActivities_219d783b-be77-45ba-b238-596dfca39431" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities_48ea89b2-2b6a-4d69-a6a7-8a532696ffd2" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_DividendsPaidToEquityHoldersOfParentClassifiedAsFinancingActivities_48ea89b2-2b6a-4d69-a6a7-8a532696ffd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsToAcquireOrRedeemEntitysShares_e15004be-b1f2-47fd-916f-f01a09001a85" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_PaymentsToAcquireOrRedeemEntitysShares"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_PaymentsToAcquireOrRedeemEntitysShares_e15004be-b1f2-47fd-916f-f01a09001a85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gsk_DistributionsToNonControllingInterestsClassifiedAsFinancingActivities_41810b72-224e-45ca-8cc0-7d227c3a3806" xlink:href="5493000HZTVUYLO1D793-2025-12-31.xsd#gsk_DistributionsToNonControllingInterestsClassifiedAsFinancingActivities"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_gsk_DistributionsToNonControllingInterestsClassifiedAsFinancingActivities_41810b72-224e-45ca-8cc0-7d227c3a3806" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromContributionsOfNoncontrollingInterests_7ce30405-8029-4683-badb-1a17ffd7ed5b" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProceedsFromContributionsOfNoncontrollingInterests"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_ProceedsFromContributionsOfNoncontrollingInterests_7ce30405-8029-4683-badb-1a17ffd7ed5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_3f5171d5-37d0-4915-9375-f19518427b51" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_9f25aeb1-faa8-4183-bd0e-d1e1dafe4364" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_3f5171d5-37d0-4915-9375-f19518427b51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperations_35460bdc-19ca-4087-862a-28d5c174ac8f" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_b871ee79-d0be-48b8-a63d-18adcb7e2a36" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperations_35460bdc-19ca-4087-862a-28d5c174ac8f" xlink:to="loc_ifrs-full_ProfitLoss_b871ee79-d0be-48b8-a63d-18adcb7e2a36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForReconcileProfitLoss_22aedf19-105b-4721-acd7-4d7278f3b359" xlink:href="https://xbrl.ifrs.org/taxonomy/2024-03-27/full_ifrs/full_ifrs-cor_2024-03-27.xsd#ifrs-full_AdjustmentsForReconcileProfitLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperations_35460bdc-19ca-4087-862a-28d5c174ac8f" xlink:to="loc_ifrs-full_AdjustmentsForReconcileProfitLoss_22aedf19-105b-4721-acd7-4d7278f3b359" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
