Immunotherapy (AIT) product to be recommended by
NICE, and the two tablets’ admission to the public
healthcare systems represents a paradigm shift in a
market, where AIT is significantly underutilised
compared to other European countries. ALK plans to
make submissions to extend the approvals of the two
tablets to include children, while also taking steps to
make GRAZAX® widely available in the UK.
ARS Pharma’s phase 2b trial to investigate neffy®’s
efficacy in acute flares in patients with chronic
spontaneous urticaria. The agreement with ARS
Pharma grants ALK exclusive rights to this and other
new indications.
Q2 SALES AND MARKET TRENDS
(Comparative figures for Q2 2024 are shown in brackets. Growth
rates are stated in local currencies, unless otherwise indicated)
Anaphylaxis
ALK launched the neffy® adrenaline nasal spray in
the first EU market end-June. German physicians
were the first to prescribe the 2 mg EURneffy® (the EU
trade name) spray to adults and children (≥ 30 kg)
facing potentially life-threatening type 1 allergic
reactions, including anaphylaxis.
Revenue by geography
DKKm
Q2
2025
1,024
269
Share of
revenue
67%
Q2
2024
900
241
233
Growth*
13%
17%
1%
Europe
North America
Int’l markets
18%
15%
234
Revenue
1,527
12%
100% 1,374
Additional launches are planned for the second half-
year in other EU countries. Market access
negotiations are progressing as planned, and a price
premium for EURneffy® relative to adrenaline
autoinjectors has been secured in Germany and
Slovenia, which were the first markets to settle
pricing and reimbursement. The initial market
response to ALK’s pre-launch and launch activities is
encouraging and the interest among allergy
specialists is generally high.
* In local currencies
Europe
Revenue in Europe grew by 13% in local currencies to
DKK 1,024 million (900). The region’s largest markets,
Germany and France, reported double-digit growth,
while single- or double-digit growth was observed in
most other markets. Tablets and anaphylaxis products
were the main sources of growth and sales of both
product groups exceeded expectations.
Furthermore, an application has been submitted to
expand the EU approval of EURneffy® to include a 1
mg version for children aged four or older and
weighing 15-30 kg.
Tablet sales increased by 17% on broad-based growth
across markets. Progress was mainly driven by higher
volumes following the 2024/25 initiation season for
tablets where the intake of new patients exceeded the
previous season by more than 10%. Volume growth
was reinforced by an inflow of particularly new
ACARIZAX® patients in Q2, as ALK continued to
mobilise patients and prescribers, and strengthen
advocacy for evidence-based, registered AIT products.
The new paediatric indications for ACARIZAX® and
ITULAZAX® contributed positively to this development,
although the input was modest, reflecting the early
stage of the ongoing launches.
Outside the EU, the 2 mg version was approved in
July in the UK, where a launch is expected in the
second half-year. The UK is Europe’s – and ALK’s –
largest anaphylaxis market. A filing has also been
made for approval in Canada, and ALK further intends
to make neffy® available in other territories covered by
the license agreement with ARS Pharma.
On 2 May, ALK entered into a four-year agreement
with ARS Pharma to co-promote neffy® to US
paediatricians. The agreement allows ALK to
accelerate the build-up of a dedicated US paediatric
sales force in a balanced way, based on performance-
based cost and revenue sharing with ARS Pharma.
The new paediatric sales force, comprising around 60
people, has been onboarded, trained, and deployed in
the field. Customer engagement progresses as
planned, and initial market feedback is positive.
Conversely, there was a reduced impact from price
and rebate adjustments compared to last year, when
these factors accounted for approximately half of
tablet sales growth in Europe.
Tablet sales growth was identical to Q1 although the
impact from inventory build-ups at wholesalers is
estimated to have declined in Q2 compared to Q1.
Combined sales of SCIT/SLIT drops increased by 1%.
Sales of SLIT-drops, which are mainly marketed in
France, increased, whereas SCIT sales fell short of
expectations with a modest decrease. In line with Q1,
this decrease was linked to fewer patients having
started treatment, combined with reduced effects from
price and rebate adjustments.
Food allergy and new disease areas
Patient recruitment for the phase 2 trial of the peanut
allergy tablet has been completed ahead of target
with 150 subjects. The trial is expected to report
topline data in H1 2026, after which ALK plans to
proceed the programme into phase 3.
Sales of Other products and services (anaphylaxis,
diagnostics, etc.) increased by 51%, driven by the
anaphylaxis portfolio, which reported 62% growth.
Work continues to develop treatments for adjacent
diseases through in-house innovation, licensing, and
partnerships. Patient recruitment has been initiated for
Page 5 of 16
Company release No 13/2025 – 21 August 2025
ALK-Abelló A/S – Bøge Allé 6-8 – DK-2970 Hørsholm – Denmark – www.alk.net
Tel +45 4574 7576 – CVR No 63 71 79 16 – LEI code: 529900SGCREUZCZ7P020