Delårsrapport2025-01-012024-01-012025-09-302024-09-30529900MTJPDPE4MHJ122Carl Jacobsens VejCarl Jacobsens Vej 30302500Valby2500 Valby2102388421023884Workiva PlatformGenmab A/SGenmab A/SNo audit assistanceReporting class Diso4217:USDiso4217:USDxbrli:sharesxbrli:pure529900MTJPDPE4MHJ1222025-01-012025-09-30529900MTJPDPE4MHJ1222025-07-012025-09-30529900MTJPDPE4MHJ1222024-07-012024-09-30529900MTJPDPE4MHJ1222024-01-012024-09-30529900MTJPDPE4MHJ1222025-09-30529900MTJPDPE4MHJ1222024-12-31529900MTJPDPE4MHJ1222023-12-31529900MTJPDPE4MHJ1222024-09-30529900MTJPDPE4MHJ1222023-12-31ifrs-full:IssuedCapitalMember529900MTJPDPE4MHJ1222023-12-31ifrs-full:SharePremiumMember529900MTJPDPE4MHJ1222023-12-31ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember529900MTJPDPE4MHJ1222023-12-31ifrs-full:RetainedEarningsMember529900MTJPDPE4MHJ1222024-01-012024-09-30ifrs-full:IssuedCapitalMember529900MTJPDPE4MHJ1222024-01-012024-09-30ifrs-full:SharePremiumMember529900MTJPDPE4MHJ1222024-01-012024-09-30ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember529900MTJPDPE4MHJ1222024-01-012024-09-30ifrs-full:RetainedEarningsMember529900MTJPDPE4MHJ1222024-09-30ifrs-full:IssuedCapitalMember529900MTJPDPE4MHJ1222024-09-30ifrs-full:SharePremiumMember529900MTJPDPE4MHJ1222024-09-30ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember529900MTJPDPE4MHJ1222024-09-30ifrs-full:RetainedEarningsMember529900MTJPDPE4MHJ1222024-12-31ifrs-full:IssuedCapitalMember529900MTJPDPE4MHJ1222024-12-31ifrs-full:SharePremiumMember529900MTJPDPE4MHJ1222024-12-31ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember529900MTJPDPE4MHJ1222024-12-31ifrs-full:RetainedEarningsMember529900MTJPDPE4MHJ1222025-01-012025-09-30ifrs-full:IssuedCapitalMember529900MTJPDPE4MHJ1222025-01-012025-09-30ifrs-full:SharePremiumMember529900MTJPDPE4MHJ1222025-01-012025-09-30ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember529900MTJPDPE4MHJ1222025-01-012025-09-30ifrs-full:RetainedEarningsMember529900MTJPDPE4MHJ1222025-09-30ifrs-full:IssuedCapitalMember529900MTJPDPE4MHJ1222025-09-30ifrs-full:SharePremiumMember529900MTJPDPE4MHJ1222025-09-30ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember529900MTJPDPE4MHJ1222025-09-30ifrs-full:RetainedEarningsMember529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember529900MTJPDPE4MHJ1222025-07-012025-09-30cmn:ConsolidatedMember529900MTJPDPE4MHJ1222024-07-012024-09-30cmn:ConsolidatedMember529900MTJPDPE4MHJ1222024-01-012024-09-30cmn:ConsolidatedMember529900MTJPDPE4MHJ1222025-01-012025-03-31cmn:ConsolidatedMember529900MTJPDPE4MHJ1222025-01-012025-09-301cmn:ConsolidatedMember529900MTJPDPE4MHJ1222025-01-012025-09-302cmn:ConsolidatedMember529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember1529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember2529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember3529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember4529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember5529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember6529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember7529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember8529900MTJPDPE4MHJ1222025-01-012025-09-30cmn:ConsolidatedMember9
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 1/43
CVR no. 2102 3884
99.1
Genmab Announces Financial Results for the Nine Months of 2025
November 6, 2025 Copenhagen, Denmark;
Interim Report for the Nine Months Ended September 30, 2025
Highlights
Announcement of Genmab’s proposed acquisition of Merus N.V. (Merus)
Genmab revenue increased 21% compared to the first nine months of 2024, to $2,662 million
FDA granted BTD to Rina-S® in advanced endometrial cancer
Epcoritamab Phase 3 EPCORE® FL-1 trial met dual primary endpoints of ORR and PFS,
demonstrating statistically significant and clinically meaningful differences in both endpoints
FDA granted priority review of the sBLA for epcoritamab plus R2 in patients with relapsed or
refractory FL
“In the third quarter we made advances that underscore the potential of our late-stage portfolio; Epcoritamab
moved closer to being available to patients in earlier lines of therapy for follicular lymphoma and Rina-S was
granted Breakthrough Therapy Designation (BTD) in advanced endometrial cancer. With robust development
plans for both epcoritamab and Rina-S and with Tivdak® (tisotumab vedotin) now available for prescribing in
Germany - our first commercial entry into a European market - we continue to execute on our strategic
imperatives to accelerate our late-stage pipeline and maximize our approved medicines to reach more patients,”
said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. “In addition, our proposed acquisition of
Merus provides us with the potential to add petosemtamab, a late-stage asset with two BTDs, to our late-stage
portfolio. This proposed transaction is expected to meaningfully accelerate our shift to a wholly owned model,
driving sustained growth into the next decade and contributing to our evolution into a global biotechnology
leader.”
Financial Performance First Nine Months of 2025
Revenue was $2,662 million for the first nine months of 2025 compared to $2,198 million for the first
nine months of 2024. The increase of $464 million, or 21%, was primarily driven by higher DARZALEX®
and Kesimpta® royalties achieved under our collaborations with Johnson & Johnson (J&J) and Novartis
Pharma AG (Novartis), respectively, and higher EPKINLY® net product sales.
Royalty revenue was $2,219 million in the first nine months of 2025 compared to $1,802 million in the
first nine months of 2024, an increase of $417 million, or 23%. The increase in royalties was driven by
higher net sales of DARZALEX and Kesimpta.
Net sales of DARZALEX (daratumumab), including sales of the subcutaneous (SC) product
(daratumumab and hyaluronidase-fihj, sold under the tradename DARZALEX FASPRO® in the U.S.) by
J&J were $10,448 million in the first nine months of 2025 compared to $8,586 million in the first nine
months of 2024, an increase of $1,862 million or 22%.
Total costs and operating expenses were $1,655 million in the first nine months of 2025 compared to
$1,536 million in the first nine months of 2024. The increase of $119 million, or 8%, was driven by the
expansion of our product pipeline, including advancement of Rina-S, the continued development of
Genmab’s broader organizational capabilities as well as profit-sharing amounts payable to AbbVie Inc.
(AbbVie) related to EPKINLY sales.
Operating profit was $1,007 million in the first nine months of 2025 compared to $662 million in the first
nine months of 2024.
Outlook
Genmab is maintaining its 2025 financial guidance published August 7, 2025.
Other Matters
Both the functional currency of the Genmab A/S legal entity and the presentation currency of the condensed
consolidated financial statements have been changed from DKK to USD effective January 1, 2025. The change
in functional currency has been implemented with prospective effect. The change in presentation currency has
been implemented with retrospective effect. Comparative figures for prior periods have been restated
accordingly.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 2/43
CVR no. 2102 3884
Genmab Announces Financial Results for the Nine Months of 2025
As disclosed in Company Announcement No. 46, Genmab and Merus announced that the companies entered
into a transaction agreement pursuant to which Genmab intends to acquire all the shares of Merus, a clinical-
stage biotechnology company with its late-stage breakthrough therapy asset petosemtamab, which is in Phase
3 development, for USD 97.00 per share in an all-cash transaction representing a transaction value of
approximately USD 8.0 billion. The transaction is not subject to a financing condition. Consideration is expected
to be funded through a combination of cash on hand and approximately $5.5 billion of non-convertible debt
financing. Genmab has obtained a funding commitment from Morgan Stanley Senior Funding, Inc. for this
amount. The financing package includes a meaningful portion of prepayable debt, in line with Genmab’s
commitment to deleveraging with a target of gross leverage <3x within two years after the closing of the
proposed transaction. On October 21, 2025, a wholly owned subsidiary of Genmab commenced a tender offer
for 100% of Merus’ common shares. The proposed transaction is anticipated to close by early in the first quarter
of 2026, subject to the satisfaction of customary closing conditions for similar transactions. In addition to the
Company Announcement, further information may be found in Notes 1 and 2, below.
Conference Call
Genmab will hold a conference call to discuss the results for the first nine months of 2025 today, Thursday,
November 6, at 6:00 pm CET, 5:00 pm GMT or 12:00 pm EST. To join the call please use the below registration
link. Registered participants will receive an email with a link to access dial-in information as well as a unique
personal PIN: https://register-conf.media-server.com/register/BI1532cd9886ad43bea2ecd7c91c404a7d. A live
and archived webcast of the call and relevant slides will be available at www.genmab.com/investor-relations.
Contact
Marisol Peron, Senior Vice President, Global Communications & Corporate Affairs
T: +1 609 524 0065; E: mmp@genmab.com
Andrew Carlsen, Vice President, Head of Investor Relations
T: +45 3377 9558; E: acn@genmab.com
*ORR = overall response rate; PFS = progression-free survival; sBLA = supplemental Biologics License Application; FDA = U.S. Food and
Drug Administration; R2 = rituximab and lenalidomide; FL = follicular lymphoma; PDUFA = Prescription Drug User Fee Act; BTD =
Breakthrough Therapy Designation
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 4/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
CONSOLIDATED KEY FIGURES
(USD million, unless otherwise indicated)
Three Months Ended
September 30,
Nine Months Ended
September 30,
Full Year
Income Statement
2025
2024
2025
2024
2024
Revenue
$1,022
$816
$2,662
$2,198
$3,121
Cost of product sales
(58)
(40)
(157)
(95)
(143)
Research and Development expenses
(357)
(336)
(1,080)
(1,032)
(1,414)
Selling, general and administrative expenses
(148)
(127)
(418)
(370)
(549)
Acquisition and integration related charges
(3)
(39)
(43)
Total costs and operating expenses
(563)
(506)
(1,655)
(1,536)
(2,149)
Operating profit
459
310
1,007
662
972
Net financial items
23
(57)
142
147
354
Net profit
$401
$186
$932
$581
$1,133
Balance Sheet
Marketable securities
$1,650
$1,648
$1,650
$1,648
$1,574
Cash and cash equivalents
1,761
952
1,761
952
1,380
Total non-current assets
2,550
2,397
2,550
2,397
2,514
Total assets
7,021
5,955
7,021
5,955
6,414
Shareholders' equity
5,751
4,793
5,751
4,793
5,137
Share capital
$10
$10
$10
$10
$10
Cash Flow Statement
Net cash provided by operating activities
$536
$299
$885
$737
$1,126
Net cash provided by (used in) investing activities
(54)
21
(71)
(1,459)
(1,447)
Net cash (used in) financing activities
(21)
(41)
(440)
(564)
(566)
Investment in intangible assets
(2)
(18)
(2)
(17)
Investment in tangible assets
$(2)
$(5)
$(24)
$(13)
$(27)
Financial Ratios and Other Information
Basic net profit per share
$6.51
$2.94
$14.95
$9.04
$17.66
Diluted net profit per share
$6.46
$2.92
$14.90
$8.99
$17.53
Period-end share market price (DKK per share)
1,928
1,620
1,928
1,620
1,493
Price / book value
$3.35
$3.38
$3.35
$3.38
$2.91
Shareholders' equity per share
$575.10
$479.30
$575.10
$479.30
$513.70
Equity ratio
82%
80%
82%
80%
80%
Shares outstanding
64,206,349
66,176,831
64,206,349
66,176,831
66,187,186
Average number of employees (FTE*)
2,663
2,591
2,656
2,488
2,535
Number of employees (FTE) at the end of the period
2,681
2,635
2,681
2,635
2,682
* Full-time equivalent or team members
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
2025 FULL YEAR OUTLOOK
(USD million)
2025 Guidance
2025 Guidance
Mid-Point
Revenue
3,500 - 3,700
3,600
  Royalties
2,945 - 3,090
3,017
  Net product sales/Collaboration revenue*
425 - 465
445
  Milestones/Reimbursement revenue
130 - 145
138
Gross profit**
3,280 - 3,460
3,370
Operating expenses**
(2,055) - (2,225)
(2,140)
Operating profit
1,055 - 1,405
1,230
* Net Product Sales and Collaboration Revenue consists of EPKINLY Net Product Sales in the U.S. and Japan and Tivdak (Genmab’s share
of net profits) in the U.S. and Net Product Sales in Japan and European Markets
** Operating Expenses Range excludes Cost of Product Sales Range, which is included in Gross Profit Range
Genmab is maintaining its 2025 financial guidance published August 7, 2025.
Revenue
Genmab expects its 2025 revenue to be in the range of $3.5 - 3.7 billion. Genmab’s projected revenue growth
for 2025 is driven by higher royalties, net product sales and collaboration revenue.
Royalty growth relates mainly to DARZALEX and Kesimpta net sales growth. DARZALEX royalties are
expected to be in the range of $2.3 - $2.4 billion and are based on Genmab’s estimate of DARZALEX 2025 net
sales of $13.7 – 14.1 billion. DARZALEX royalties are partly offset by Genmab’s share of Janssen’s royalty
payments to Halozyme Therapeutics, Inc. (Halozyme) in connection with SC net sales as well as royalty
reduction in countries and territories where there are no Genmab patents.
Operating Expenses
Genmab is maintaining its 2025 operating expenses to be in the range of $2.1 - 2.2 billion.
Operating Profit
Genmab expects its 2025 operating profit to be in the range of $1.1 - 1.4 billion, primarily driven by the items
described above.
Outlook: Risks and Assumptions
In addition to factors already mentioned, the estimates above are subject to change due to numerous reasons,
including but not limited to, the achievement of certain milestones associated with Genmab’s collaboration
agreements; the timing and variation of development activities (including activities carried out by Genmab’s
collaboration partners) and related income and costs; DARZALEX, DARZALEX FASPRO, Kesimpta,
TEPEZZA®, RYBREVANT®, TECVAYLI®, TALVEY® and TEPKINLY® net sales and royalties paid to Genmab;
changing rates of inflation; and currency exchange rates. The financial guidance assumes that no significant
new agreements are entered into during the remainder of 2025 that could materially affect the results. Refer to
the section “Significant Risks and Uncertainties” in this interim report for matters that may cause Genmab’s
actual results to differ materially from 2025 Guidance.
The factors discussed above, as well as other factors that are currently unforeseeable, may result in further and
other unforeseen material adverse impacts on Genmab’s business and financial performance, including on the
sales of Tivdak and EPKINLY/TEPKINLY, and on the net sales of DARZALEX, Kesimpta, TEPEZZA,
RYBREVANT, TECVAYLI and TALVEY by Genmab’s collaboration partners and on Genmab’s royalties,
collaboration revenue and milestone revenue therefrom.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
PRODUCT PIPELINE AND TECHNOLOGY PROGRESS NINE MONTHS OF 2025
At the end of the first nine months of 2025, Genmab’s proprietary pipeline of investigational medicines, where
we are responsible for at least 50% of development, consisted of  nine antibody products in clinical
development. These include Genmab’s approved medicines, Tivdak, which Genmab is co-developing globally
and co-promoting in the U.S. in collaboration with Pfizer Inc. (Pfizer) and exclusively by Genmab outside of the
U.S. and China, and EPKINLY/TEPKINLY, which Genmab is co-developing and co-commercializing in the U.S.
and Japan in collaboration with AbbVie Inc. (AbbVie). In addition to our own pipeline, there are multiple
investigational medicines in development by global pharmaceutical and biotechnology companies, including six
approved medicines powered by Genmab’s technology and innovations. Beyond the investigational medicines
in clinical development, our pipeline includes multiple preclinical programs. An overview of the development
status of our approved medicines and each of our investigational medicines is provided in the following section,
including updates for the third quarter of 2025. For events that occurred during the first and second quarters of
2025, please refer to Genmab’s Q1 2025 and Genmab’s First Half 2025 reports. Detailed descriptions of dosing,
efficacy and safety data from certain clinical trials have been disclosed in company announcements and media
releases published via the Nasdaq Copenhagen A/S (Nasdaq Copenhagen) stock exchange and may also be
found in Genmab’s filings with the U.S. Securities and Exchange Commission (U.S. SEC). Additional
information is available on Genmab’s website, www.genmab.com. The information accessible through our
website is not part of this report and is not incorporated by reference herein.
Genmab Proprietary Products1
Approved Medicines
Approved Product
Target
Developed By
Disease Indication2
EPKINLY
(epcoritamab-bysp,
epcoritamab)
TEPKINLY
(epcoritamab)
CD3xCD20
Co-development
Genmab/AbbVie
Approved in multiple territories including in the U.S.
and Europe for adult patients with relapsed or
refractory diffuse large B-cell lymphoma (DLBCL)
after two or more lines of systemic therapy and in
Japan for adult patients with certain types of relapsed
or refractory large B-cell lymphoma (LBCL) after two
or more lines of systemic therapy
Approved in multiple territories including the U.S.,
Europe and Japan for adult patients with relapsed or
refractory FL after two or more lines of systemic
therapy
Tivdak
(tisotumab vedotin-
tftv, tisotumab
vedotin)
Tissue
factor (TF)
Co-development
Genmab/Pfizer
Approved in the U.S., Europe and Japan for adult
patients with recurrent/metastatic cervical cancer with
disease progression on or after chemotherapy
1 Approved and investigational medicines where Genmab has ≥50% ownership, in co-development with partners as indicated.
2 Refer to relevant local prescribing information for precise indication and safety information.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Pipeline, Including Further Development for Approved Medicines
Product
Developed By
Target(s)
Technology
Disease Indications
Most Advanced Development Phase
Preclinical
1
2
3
Epcoritamab
Co-development
Genmab / AbbVie
CD3, CD20
DuoBody®
Relapsed/refractory DLBCL
Relapsed/refractory FL
First line DLBCL
First line FL
B-cell non-Hodgkin lymphoma (NHL)
Relapsed/refractory chronic
lymphocytic leukemia (CLL) &
Richter's Syndrome
Aggressive mature B-cell neoplasms
in pediatric patients
Tisotumab
vedotin
Co-development
Genmab / Pfizer
TF
Antibody-drug
conjugate (ADC)
Solid tumors
Rinatabart
Sesutecan
(Rina-S,
GEN1184)
Genmab
Folate receptor
alpha
(FRα)
ADC
Platinum resistant ovarian cancer
(PROC)
2L+ endometrial cancer
Solid tumors
Acasunlimab
(GEN1046)
Genmab
Programmed
death ligand 1
(PD-L1), 4-1BB
DuoBody
Non-small cell lung cancer (NSCLC)
Advanced melanoma
Solid tumors
GEN1042
(BNT312)
Co-development
Genmab / BioNTech
SE (BioNTech)
CD40, 4-1BB
DuoBody
Solid tumors
GEN1059
(BNT314)
Co-development
Genmab / BioNTech
Epithelial cell
adhesion
molecule
(EpCAM), 4-1BB
DuoBody
Solid tumors
Metastatic colorectal cancer (mCRC),
in combination with pumitamig/
chemo
GEN1160
Genmab
CD70
ADC
Advanced solid and liquid tumors
GEN1057
Genmab
Fibroblast
activation
protein alpha
(FAPα), death
receptor 4 (DR4)
DuoBody
Malignant solid tumors
GEN1286
Genmab
Epidermal
growth factor
receptor
(EGFR), cellular-
mesenchymal
epithelial
transition factor
receptor tyrosine
kinase (cMET)
ADC
Advanced solid tumors
EPKINLY/TEPKINLY (epcoritamab) – the only bispecific antibody approved with a dual indication for the
treatment of certain B-cell malignancies in the U.S., Europe and Japan 
Epcoritamab (approved as EPKINLY and TEPKINLY) has received regulatory approvals in multiple
territories including in the U.S. and Europe for adult patients with relapsed or refractory DLBCL after two
or more lines of systemic therapy, and in Japan for adult patients with certain types of relapsed or
refractory LBCL after two or more lines of systemic therapy
EPKINLY/TEPKINLY has also been approved in multiple territories including the U.S., Japan and
Europe for the treatment of adults with relapsed or refractory FL after two or more lines of systemic
therapy
More than 40 clinical trials are ongoing across different treatment settings, lines of therapy and in
combination regimens across histologies, including five Phase 3 trials and additional trials in
development
Two BTDs granted by the FDA for relapsed/refractory FL: as monotherapy after two or more therapies
and in combination with R2 following at least one prior systemic therapy
SC bispecific antibody targeting CD3 and CD20, created using Genmab’s DuoBody technology platform
Co-developed and co-commercialized in collaboration with AbbVie
Epcoritamab is a proprietary bispecific antibody created using Genmab’s DuoBody technology platform.
Epcoritamab targets CD3, which is expressed on T-cells, and CD20, a clinically validated target on malignant B-
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 8/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
cells. Genmab used technology licensed from Medarex Inc. (Medarex) to generate the CD20 antibody forming
part of epcoritamab. Epcoritamab is marketed as EPKINLY in the U.S., Japan, and other regions, and as
TEPKINLY in Europe and other regions. See local prescribing information for specific indications and safety
information. In 2020, Genmab entered into a collaboration agreement with AbbVie to jointly develop and
commercialize epcoritamab. The companies share commercialization responsibilities in the U.S. and Japan,
with AbbVie responsible for further global commercialization.
Genmab records sales in the U.S. and Japan and receives tiered royalties between 22% and 26% on remaining
global sales outside of these territories, subject to certain royalty reductions. The companies have a broad
clinical development program for epcoritamab including five ongoing Phase 3 trials and additional trials in
planning. Please consult the U.S. Prescribing Information for EPKINLY and the European Summary of Product
Characteristics for TEPKINLY for the labeled indication and safety information.
Third Quarter 2025 Updates
July: The FDA accepted for priority review the sBLA for epcoritamab in combination with R2 for the
treatment of adult patients with relapsed or refractory FL, following at least one prior systemic therapy.
The sBLA submission was based on data from the first interim analysis of the Phase 3 EPCORE® FL-1
(NCT05409066) trial. Under the PDUFA, the FDA has set a target action date of November 30, 2025. If
approved, epcoritamab plus R2 would be the first bispecific antibody combination regimen available in
the U.S. as a second-line treatment option for patients with relapsed/refractory FL.
August: In a second pre-planned interim analysis the Phase 3 EPCORE FL-1 trial met its dual primary
endpoints of ORR and PFS. The safety profile of epcoritamab in combination with R2 was consistent
with the known safety profiles of the individual regimens and as presented in the U.S. prescribing
information for epcoritamab. These results will serve as the basis for global regulatory submissions.
September: Updated results from the outpatient Phase 2 EPCORE NHL-6 trial (NCT05451810) were
presented as a poster at the 13th Society of Hematologic Oncology Annual Meeting. These results
demonstrated the feasibility of treating and monitoring patients in an outpatient setting following the first
dose of epcoritamab and showed that the incidence and severity of adverse events associated with
epcoritamab were consistent with previous epcoritamab studies in patients with relapsed/refractory
DLBCL.
Tivdak (tisotumab vedotin) – First and only ADC for recurrent or metastatic cervical cancer in the U.S.,
Europe and Japan
An ADC directed to TF, a protein highly prevalent in solid tumors, including cervical cancer, which is
associated with poor prognosis
Tisotumab vedotin, approved as Tivdak, is the first and only ADC approved in the U.S., Europe and
Japan for the treatment of recurrent or metastatic cervical cancer after prior therapy and is the only ADC
with demonstrated overall survival data in this setting compared to chemotherapy
Co-developed globally and co-promoted in the U.S. in collaboration with Pfizer, exclusively by Genmab
outside of the U.S. and China
Tisotumab vedotin is an ADC composed of Genmab’s human monoclonal antibody directed to TF and Pfizer’s
ADC technology that utilizes a protease-cleavable linker that covalently attaches the microtubule-disrupting
agent monomethyl auristatin E (MMAE) to the antibody. Genmab used technology licensed from Medarex to
generate the TF antibody forming part of tisotumab vedotin. Tisotumab vedotin, marketed as Tivdak, is the first
and only ADC approved for the treatment of adult patients with recurrent or metastatic cervical cancer after prior
therapy in the U.S., Europe and Japan. Tisotumab vedotin is being co-developed by Genmab and Pfizer. Under
a joint commercialization agreement, Genmab is co-promoting Tivdak in the U.S. and is leading commercial
operational activities in Japan, Europe and all other regions globally, excluding the United States and China.
Pfizer is leading commercial operational activities in the U.S. and will lead commercial operational activities in
China once approved in connection with the sublicense of its rights to develop and commercialize tisotumab
vedotin in China to Zai Lab. Genmab will record sales for Europe, Japan and rest of world markets (excluding
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
the United States and China), and will provide royalties in the low teens to Pfizer on net sales. The companies
have joint decision-making power on the worldwide development and commercialization strategy for Tivdak.
Please consult the U.S. Prescribing Information and the European Summary of Product Characteristics for the
labeled indication and safety information for Tivdak.
Third Quarter 2025 Update
September: Tivdak became available for prescribing in Germany. This is the first European country
where this medicine is commercially available following approval by the European Commission in
March 2025.
Rinatabart Sesutecan (Rina-S, GEN1184) – Potential best-in-class FRα-targeted topoisomerase I
(TOPO1) ADC
FRα-targeted TOPO1 ADC being evaluated for potential treatment of FRα-expressing cancers
Phase 3 clinical trial (NCT06619236) in PROC is recruiting
Phase 2 clinical trials (dose expansion arms of NCT05579366) in PROC and second line plus
endometrial cancer are recruiting
Additional trials announced including Phase 3 trials in second line plus endometrial cancer, second line
platinum sensitive ovarian cancer (PSOC), and a planned Phase 2 trial in NSCLC
Rina-S is a novel FRα-targeted TOPO1 ADC being evaluated for the potential treatment of ovarian cancer,
endometrial cancer and other FRα-expressing cancers. Dose expansion data suggests that Rina-S has robust
single agent activity in various cancers across a broad range of FRα expression levels. In January 2024, Rina-S
was granted Fast Track Designation by the FDA for the treatment of FRα-expressing high-grade serous or
endometrioid PROC. A Phase 3 trial in second line plus platinum PROC is recruiting.
Third Quarter 2025 Update
August: The FDA granted BTD to Rina-S for the treatment of adult patients with recurrent or progressive
endometrial cancer who have disease progression on or following prior treatment with a platinum-
containing regimen and a PD-(L)1 therapy.
Acasunlimab (GEN1046) – Bispecific next-generation immunotherapy
Bispecific antibody targeting PD-L1 and 4-1BB, created using Genmab’s DuoBody technology platform
A Phase 3 trial (NCT06635824, ABBIL1TY NSCLC-06) NSCLC is recruiting
Acasunlimab (GEN1046, DuoBody-PD-L1x4-1BB) is a proprietary bispecific antibody, created using Genmab’s
DuoBody technology platform. Originally developed in collaboration with BioNTech, in 2024 Genmab assumed
sole responsibility for the continued development and potential commercialization of acasunlimab. The program
will be subject to payment of certain milestones and a tiered single-digit royalty on net sales by Genmab to
BioNTech. Acasunlimab is designed to induce an antitumor immune response by simultaneous and
complementary PD-L1 blockade and conditional 4-1BB stimulation using an inert DuoBody format. A Phase 3
trial of acasunlimab in combination with pembrolizumab compared to docetaxel in checkpoint inhibitor (CPI)-
experienced, PD-L1 positive metastatic NSCLC is recruiting. A Phase 2 trial (NCT06984328,  ABBIL1TY
MELANOMA-07) of acasunlimab alone and with pembrolizumab to treat advanced melanoma of the skin that
has returned after treatment with an approved checkpoint inhibitor therapy is in planning.
GEN1042 (BNT312) – Bispecific antibody targeting CD40 and 4-1BB
Bispecific antibody targeting CD40 and 4-1BB, created using Genmab’s DuoBody technology platform
Multiple clinical trials in solid tumors ongoing
Co-developed in collaboration with BioNTech
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
GEN1042 (DuoBody-CD40x4-1BB, BNT312) is a proprietary bispecific antibody, jointly owned by Genmab and
BioNTech, created using Genmab’s DuoBody technology platform. It is being co-developed by Genmab and
BioNTech under an agreement in which the companies share all costs and future potential profits for GEN1042
on a 50:50 basis. CD40 and 4-1BB were selected as targets to enhance activation of both dendritic cells and
antigen-dependent T-cells. Three clinical trials of GEN1042 in solid tumors are ongoing. Based on the current
data, including a preliminary cohort analysis in frontline head and neck squamous cell carcinoma that did not
meet our high bar for continued development, Genmab and BioNTech have agreed that no further development
will be planned for GEN1042 in combination with pembrolizumab and chemotherapy beyond the currently
ongoing clinical trials. The companies will evaluate the option for future potential combination opportunities with
GEN1042.
GEN1059 (BNT314) – Bispecific antibody with potential in solid tumors
Bispecific antibody targeting EpCAM and 4-1BB, created using Genmab’s DuoBody technology
platform
Phase 1 clinical trials are ongoing
Co-developed in collaboration with BioNTech
GEN1059 (DuoBody-EpCAMx4-1BB, BNT314), jointly owned by Genmab and BioNTech and created using
Genmab’s DuoBody technology platform, is a bispecific antibody aimed at boosting antitumor immune
responses through EpCAM-dependent 4-1BB agonistic activity. GEN1059 is being co-developed by Genmab
and BioNTech under an agreement in which the companies share all costs and future potential profits for
GEN1059 on a 50:50 basis. A Phase 1 clinical trial (NCT06150183) of GEN1059 in solid tumors is ongoing and
a Phase 1 trial (NCT07079631) in mCRC in combination with BioNTech and Bristol Myers Squibb’s pumitamig
(an immune checkpoint inhibitor) and chemotherapy is recruiting.
GEN1160 – ADC with potential in both solid tumors and hematological malignancies
CD70-targeted ADC being evaluated in advanced solid and liquid tumors
Phase 1/2 clinical trial (NCT05721222) in advanced solid and liquid tumors is recruiting
GEN1160 is a CD70-targeted ADC created using Genmab’s ADC technology. CD70 is a protein expressed on
both solid tumors and hematological malignancies. A Phase 1/2 clinical study of GEN1160 in advanced renal
cell carcinoma, nasopharyngeal carcinoma and NHL is recruiting.
GEN1107 – ADC with potential in solid tumors
PTK7-targeted ADC with potential in advanced solid tumors
GEN1107 is a PTK7-targeted ADC created using Genmab’s ADC technology. PTK7 is a clinically validated ADC
target with broad solid tumor expression, particularly in tumor-initiating cells. Genmab has decided to
discontinue the clinical development of GEN1107 as the overall benefit-risk profile no longer supports
continuation.
GEN1057 – Bispecific antibody with potential in solid tumors
Bispecific antibody targeting FAPα and DR4, created using Genmab’s DuoBody technology platform
Phase 1/2 clinical trial (NCT06573294) in malignant solid tumors is recruiting
GEN1057 (DuoBody-FAPαxDR4) is a bispecific antibody-based investigational medicine created using
Genmab’s DuoBody technology platform. GEN1057 is designed for the conditional DR4 transactivation-
mediated tumor cell killing by crosslinking FAPα expression on cancer-associated fibroplasts with DR4
expressed on tumor cells. A Phase 1/2 clinical trial of GEN1057 in malignant solid tumors is recruiting.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
GEN1286 – ADC with potential in solid tumors
ADC that targets EGFR and cMet being evaluated in advanced solid tumors
Phase 1/2 clinical trial (NCT06685068) in advanced solid tumors is recruiting
GEN1286 is an ADC targeting EGFR and cMet, two validated cancer targets created using Genmab’s ADC
technology. A Phase 1/2 clinical study of GEN1286 in advanced solid tumors is recruiting.
Preclinical Programs
Broad preclinical pipeline that includes both partnered products and in-house programs based on our
proprietary technologies and/or antibodies
Multiple new Investigational New Drug (IND) applications expected to be submitted over the coming
years
Genmab has entered multiple strategic collaborations to support the expansion of our innovative
pipeline, including our acquisition of ProfoundBio in 2024
Our preclinical pipeline includes immune effector function enhanced antibodies developed with our HexaBody
technology platform, bispecific antibodies created with our DuoBody technology platform and ADCs created with
our ADC technology platforms. We are also collaborating with our partners to generate additional new antibody-
based product concepts. A number of the preclinical programs are conducted in cooperation with our
collaboration partners.
Programs Incorporating Genmab’s Innovation and Technology1
In addition to Genmab’s own pipeline of investigational medicines and preclinical pipeline candidates, our
innovations and proprietary technology platforms are applied in the pipelines of global pharmaceutical and
biotechnology companies. These companies are running clinical development programs with antibodies created
by Genmab or created using Genmab’s proprietary DuoBody bispecific antibody technology platform.
The information in this section includes those therapies that have been approved by regulatory agencies in
certain territories. Under the agreements for these medicines Genmab is entitled to certain potential milestones
and royalties.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Approved Medicines
Approved Product
Discovered and/or Developed &
Marketed By
Disease Indication(s)2
DARZALEX
(daratumumab)/
DARZALEX  FASPRO 
(daratumumab and hyaluronidase-
fihj)
J&J (Royalties to Genmab on global
net sales)
Multiple myeloma
Light-chain (AL) Amyloidosis
Kesimpta
(ofatumumab)
Novartis (Royalties to Genmab on
global net sales)
Relapsing multiple sclerosis (RMS)
TEPEZZA
(teprotumumab-trbw)
Amgen Inc. (Amgen) (under
sublicense from Roche, royalties to
Genmab on global net sales)
Thyroid Eye Disease (TED)
RYBREVANT
(amivantamab/amivantamab-vmjw)
J&J (Royalties to Genmab on global
net sales)
Advanced NSCLC with certain EGFR
mutations
TECVAYLI
(teclistamab/teclistamab-cqyv)
J&J (Royalties to Genmab on global
net sales)
Relapsed and refractory multiple
myeloma
TALVEY
(talquetamab/talquetamab-tgvs)
J&J (Royalties to Genmab on global
net sales)
Relapsed and refractory multiple
myeloma
1 Approved and investigational medicines created by Genmab or created by collaboration partners leveraging Genmab’s DuoBody
technology platform, under development, and where relevant, commercialized by a third party.
2 See local prescribing information for precise indication and safety information.
Pipeline, Including Further Development for Approved Medicines, ≥ Phase 2 Development
Product
Technology
Discovered and/or
Developed By
Disease Indications
Most Advanced Development Phase
Preclinical
1
2
3
Daratumumab
UltiMAb*
J&J
Multiple myeloma
AL Amyloidosis
Teprotumumab
UltiMAb
Amgen
TED
Amivantamab
DuoBody
J&J
NSCLC
Advanced or metastatic
colorectal cancer
Recurrent/metastatic head and
neck cancer
Teclistamab
DuoBody
J&J
Multiple myeloma
Talquetamab
DuoBody
J&J
Multiple myeloma
Amlenetug
(Lu AF82422)
UltiMAb
Lundbeck
Multiple system atrophy
Inclacumab
UltiMAb
Pfizer
Sickle cell disease
Mim8 (denecimig)
DuoBody
Novo Nordisk
Hemophilia A
* UltiMAb transgenic mouse technology licensed from Medarex, a wholly owned subsidiary of Bristol-Myers Squibb.
DARZALEX (daratumumab) – Redefining the treatment of multiple myeloma
First-in-class human CD38 monoclonal antibody
Developed and commercialized by J&J under an exclusive worldwide license from Genmab
Intravenous (IV) formulation approved in combination with other therapies and as monotherapy for
certain multiple myeloma indications
First and only SC CD38-directed antibody approved for the treatment of certain multiple myeloma
indications, known as DARZALEX FASPRO in the U.S., and DARZALEX SC in Europe
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 13/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
First licensed treatment for patients with high-risk smoldering multiple myeloma (SMM), approved in
Europe
SC daratumumab is the first and only approved therapy for AL amyloidosis in the U.S., Europe, and
Japan
Daratumumab is a human monoclonal antibody that binds with high affinity to the CD38 molecule, which is
highly expressed on the surface of multiple myeloma cells and is also expressed by AL amyloidosis plasma
cells. Genmab used technology licensed from Medarex to generate the CD38 antibody. Daratumumab is being
developed and commercialized by J&J under an exclusive worldwide license from Genmab. Under the terms of
the agreement, Genmab receives royalties between 12% and 20% with J&J reducing such royalty payments for
Genmab’s share of J&J’s royalty payments made to Halozyme; payments are further reduced in countries and
territories where there are no relevant patents. Daratumumab (marketed as DARZALEX for IV administration
and as DARZALEX FASPRO in the U.S. and as DARZALEX SC in Europe for SC administration) is approved in
a large number of territories for the treatment of adult patients with certain multiple myeloma indications and is
the only approved therapy for the treatment of patients with high-risk SMM, approved in Europe. It is also the
only approved therapy in the U.S., Europe and Japan for the treatment of adult patients with AL amyloidosis.
Please consult the European Summary of Product Characteristics for DARZALEX and DARZALEX SC and the
U.S. Prescribing Information for DARZALEX and DARZALEX FASPRO for the labeled indication and safety
information.
Kesimpta (ofatumumab) – Approved for the treatment of RMS
Human CD20 monoclonal antibody developed and commercialized by Novartis under a license
agreement with Genmab
Approved in multiple territories including the U.S., Europe and Japan for the treatment of RMS in adults
First B-cell therapy that can be self-administered by patients using the Sensoready® autoinjector pen
Ofatumumab is a human monoclonal antibody that targets an epitope on the CD20 molecule encompassing
parts of the small and large extracellular loops. Genmab used technology licensed from Medarex to generate
the CD20 antibody. Ofatumumab, marketed as Kesimpta, is approved in territories including the U.S., Europe,
and Japan for the treatment of certain adult patients with RMS. Kesimpta is the first B-cell therapy that can be
self-administered by patients using the Sensoready autoinjector pen, once monthly after starting therapy.
Ofatumumab is being developed and marketed worldwide by Novartis under a license agreement between
Genmab and Novartis. Under the terms of the agreement, Genmab receives a 10% royalty on net sales of
Kesimpta, and Genmab pays a low-single digit royalty to Medarex based on Kesimpta sales. Please consult
the U.S. Prescribing Information and the European Summary of Product Characteristics for the labeled
indication and safety information for Kesimpta.
TEPEZZA (teprotumumab) – First FDA-approved medicine for the treatment of TED
Developed and commercialized by Amgen for the treatment of TED
First and only approved medicine for the treatment of TED in the U.S., Japan and Europe
Teprotumumab, approved in the U.S., Japan and Europe under the trade name TEPEZZA, is a human
monoclonal antibody that targets the Insulin-like Growth Factor 1 Receptor (IGF-1R), a validated target. It is the
first and only medicine approved for the treatment of TED. Genmab used technology licensed from Medarex to
generate the IGF-1R antibody. The antibody was created by Genmab under a collaboration with Roche.
Development and commercialization of the product is currently being conducted by Amgen. Under the terms of
Genmab’s original agreement with Roche, Genmab receives a mid-single digit royalty on net sales (as defined)
of TEPEZZA. Please consult the U.S. Prescribing Information and the European Summary of Product
Characteristics for the labeled indication and safety information for TEPEZZA.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
RYBREVANT (amivantamab) – Bispecific antibody approved for the treatment of NSCLC
Part of Genmab and J&J DuoBody research and license agreement
First approved medicine created using Genmab’s proprietary DuoBody technology
Under the agreement with J&J, Genmab is eligible to receive milestones and receives royalties on net
sales of RYBREVANT
In July 2012, and as amended in December 2013, Genmab entered into a collaboration with J&J to create and
develop bispecific antibodies using Genmab’s DuoBody technology platform. One of these, J&J’s amivantamab,
is a fully human bispecific antibody that targets EGFR and cMet, two validated cancer targets. The two antibody
libraries used to produce amivantamab were both generated by Genmab. In collaboration with J&J, the antibody
pair used to create amivantamab was co-discovered. Amivantamab, marketed as RYBREVANT, is approved in
territories including the U.S., Europe and Japan for the treatment of certain adult patients with NSCLC. J&J is
responsible for the development and commercialization of amivantamab. Under the terms of the agreement,
Genmab receives royalties between 8% and 10% on net sales of RYBREVANT with J&J reducing such royalty
payments for Genmab’s share of J&J’s royalty payments made to Halozyme; payments are further reduced in
countries and territories where there are no relevant patents. Genmab pays a royalty to Medarex based on
RYBREVANT net sales. Please consult the U.S. Prescribing Information and the European Summary of Product
Characteristics for RYBREVANT for the labeled indication and safety information.
TECVAYLI (teclistamab) – Bispecific antibody approved for the treatment of relapsed and refractory
multiple myeloma
Part of Genmab and J&J DuoBody research and license agreement
Second approved medicine created using Genmab’s proprietary DuoBody technology
Under the agreement with J&J, Genmab is eligible to receive milestones and receives royalties on net
sales of TECVAYLI
In July 2012, and as amended in December 2013, Genmab entered into a collaboration with J&J to create and
develop bispecific antibodies using Genmab’s DuoBody technology platform. One of the products subsequently
discovered and developed by J&J is teclistamab, a bispecific antibody that targets CD3, which is expressed on
T-cells, and B-cell maturation antigen (BCMA), which is expressed in mature B lymphocytes. Teclistamab,
marketed as TECVAYLI, is approved in certain territories including the U.S., Europe and Japan for the treatment
of certain adult patients with relapsed or refractory multiple myeloma. J&J is responsible for the development
and commercialization of TECVAYLI. Under our agreement with J&J, Genmab is eligible to receive milestones
and receives a mid-single digit royalty on net sales of TECVAYLI subject to a reduction of such royalty payments
in countries and territories where there are no relevant patents, among other reductions. Please consult
the U.S. Prescribing Information and the European Summary of Product Characteristics for TECVAYLI for the
labeled indication and safety information.
TALVEY (talquetamab) – Bispecific antibody approved for the treatment of relapsed and refractory
multiple myeloma
Part of Genmab and J&J DuoBody research and license agreement
Fourth approved medicine created using Genmab’s proprietary DuoBody technology
Under the agreement with J&J, Genmab is eligible to receive milestones and royalties on net sales of
TALVEY
In July 2012, and as amended in December 2013, Genmab entered into a collaboration with J&J to create and
develop bispecific antibodies using Genmab’s DuoBody technology platform. One of the products subsequently
discovered and developed by J&J is talquetamab, a bispecific antibody that targets CD3, which is expressed on
T-cells, and G protein-coupled receptor, family C, group 5, member D (GPRC5D), an orphan receptor
expressed in malignant plasma cells. Talquetamab, marketed as TALVEY, is approved in certain territories
including the U.S. and Europe for the treatment of certain adult patients with relapsed or refractory multiple
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
myeloma. J&J is responsible for the development and commercialization of TALVEY. Under our agreement with
J&J, Genmab is eligible to receive milestones and receives a mid-single digit royalty on net sales of TALVEY
subject to a reduction of such royalty payments in countries and territories where there are no relevant patents,
among other reductions. Please consult the U.S. Prescribing Information and the European Summary of
Product Characteristics for TALVEY for the labeled indication and safety information.
SIGNIFICANT RISKS AND UNCERTAINTIES
As a biotech company, Genmab faces a number of risks and uncertainties. These are common for the industry
and relate to operations, intellectual property, research and development, commercialization, and financial
activities.
Genmab is exposed to increasing risks related to evolving trade policies, including tariffs and other trade
restrictions, which may increase costs or create regulatory uncertainty in key markets. In addition, changes
made at the FDA may lead to delays in regulatory reviews, which could impact the timing of clinical milestones
and product launches.
For further information about risks and uncertainties that Genmab faces, refer to the 2024 Annual Report filed
with the Nasdaq Copenhagen and the Form 20-F filed with the U.S. SEC, both of which were filed in February
2025. At the date of this interim report, there have been no significant changes to Genmab’s overall risk profile
since the publication of these reports. See Genmab’s Form 20-F for a detailed summary of risks related to our
collaborations.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
FINANCIAL REVIEW
The interim report is prepared on a consolidated basis for Genmab A/S (parent company) and its subsidiaries.
Management determined it is appropriate to change both the functional currency of the Genmab A/S legal entity
and the presentation currency of the condensed consolidated financial statements from DKK to USD effective
January 1, 2025. The change in functional currency was triggered by the commercialization of EPKINLY and
was made to reflect that USD has become the predominant currency of the Genmab A/S legal entity. The
change has been implemented with prospective effect. The change in presentation currency is applied
retrospectively and was made to better reflect the Company’s financial position. Comparative figures for prior
periods have been restated accordingly. The symbol “$” is used throughout this interim report to refer to the
U.S. dollar. The Genmab consolidated Group is referenced herein as “Genmab” or the “Company.”
(In all accompanying tables, amounts of dollars are expressed in millions, except per share amounts, unless
otherwise noted).
Revenue
Genmab’s revenue was $2,662 million for the first nine months of 2025 compared to $2,198 million for the first
nine months of 2024. The increase of $464 million, or 21%, was primarily driven by higher DARZALEX and
Kesimpta royalties achieved under our collaborations with J&J and Novartis, respectively, and increased
EPKINLY net product sales. This increase was partly offset by reduced reimbursement revenue associated with
Genmab assuming full control of development, as well as future commercialization, of the acasunlimab
program, effective in the second half of 2024.
Three Months Ended
September 30,
Nine Months Ended
September 30,
2025
2024
2025
2024
Royalties
$841
$691
$2,219
$1,802
Reimbursement revenue
7
39
43
121
Milestone revenue
53
1
66
51
Collaboration revenue
17
15
54
45
Net product sales
104
70
280
179
Total revenue
$1,022
$816
$2,662
$2,198
Royalties
Royalty revenue amounted to $2,219 million in the first nine months of 2025 compared to $1,802 million in the
first nine months of 2024. The increase of $417 million, or 23%, was primarily driven by higher DARZALEX and
Kesimpta royalties achieved under our daratumumab collaboration with J&J and ofatumumab collaboration with
Novartis. The table below summarizes Genmab’s royalty revenue by product.
Three Months Ended
September 30,
Nine Months Ended
September 30,
2025
2024
2025
2024
DARZALEX
$656
$557
$1,744
$1,442
Kesimpta
122
84
320
228
TEPEZZA
30
29
75
78
Other
33
21
80
54
Total royalties
$841
$691
$2,219
$1,802
J&J’s net sales of DARZALEX were $10,448 million in the first nine months of 2025 compared to $8,586 million
in the first nine months of 2024. The increase of $1,862 million, or 22%, was driven by market share gains and
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
market growth in all regions. Royalty revenue on net sales of DARZALEX was $1,744 million in the first nine
months of 2025 compared to $1,442 million in the first nine months of 2024, an increase of $302 million. The
percentage increase in royalties of 21% is in line with the percentage increase in the underlying net sales.
Novartis’ net sales of Kesimpta were $3,198 million in the first nine months of 2025 compared to $2,274 million
in the first nine months of 2024. The increase of $924 million, or 41%, was primarily driven by increased
demand and strong access. Royalty revenue on net sales of Kesimpta was $320 million in the first nine months
of 2025 compared to $228 million in the first nine months of 2024, an increase of $92 million, or 40%.
Amgen’s net sales of TEPEZZA were $1,446 million in the first nine months of 2025 compared to $1,391 million
in the first nine months of 2024. Royalty revenue on net sales of TEPEZZA was $75 million in the first nine
months of 2025 compared to $78 million in the first nine months of 2024, a decrease of $3 million, or 4%, which
is in line with the slight reduction of net sales.
Other royalties consist of royalties from net sales of RYBREVANT, TECVAYLI, TALVEY and TEPKINLY. These
royalties were not material for the first nine months of 2025 or 2024.
Royalty revenue fluctuations from period to period are driven by the level of product net sales, foreign currency
exchange rate movements and more specifically to DARZALEX, the contractual arrangement related to annual
Currency Hedge Rate, Genmab’s share of J&J’s royalty payments to Halozyme in connection with SC product
net sales and the level of royalty deductions on net sales in countries and territories where there is no patent
protection.
Reimbursement Revenue
Reimbursement revenue amounted to $43 million in the nine months of 2025 compared to $121 million in the
first nine months of 2024 . The decrease of $78 million, or 64%, was primarily driven by Genmab assuming full
control of development, as well as future commercialization, of the acasunlimab program, effective in the
second half of 2024. 
Milestone Revenue
Milestone revenue was $66 million in the first nine months of 2025 compared to $51 million in the first nine
months of 2024, an increase of $15 million, or 29%, primarily driven by milestones achieved under our
collaborations with AbbVie for $30 million, J&J for $20 million and Novo Nordisk for $13 million as compared to
a milestone achieved under our collaboration with AbbVie for $50 million in the first nine months of 2024.
Milestone revenue may fluctuate significantly from period to period due to both the timing of achievements and
the varying amount of each individual milestone under our license and collaboration agreements.
Collaboration Revenue
Collaboration revenue was $54 million in the first nine months of 2025 compared to $45 million in the first nine
months of 2024, an increase of $9 million, or 20%, primarily driven by an increase in net sales of Tivdak in the
U.S. by Pfizer.
Net Product Sales
Genmab’s net product sales include sales of EPKINLY in the U.S. and Japan and Tivdak in Japan and
Germany. Global net sales of EPKINLY/TEPKINLY were $333 million in the first nine months of 2025 compared
to $203 million in the first nine months of 2024, an increase of $130 million or 64%, driven by strong growth in
3L+ DLBCL and the expansion to address a second indication, 3L+ FL, which was approved in the U.S. in June
2024. Net product sales of EPKINLY in the U.S. and Japan recorded by Genmab were $272 million in the first
nine months of 2025 compared to $179 million in the first nine months of 2024. EPKINLY was approved in the
U.S. in May 2023 and in Japan in September 2023.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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Interim Report for the Nine Months of 2025
Net sales of TEPKINLY in territories where Genmab receives royalty revenue were $61 million in the first nine
months of 2025 compared to $24 million in the first nine months of 2024.
Net product sales of Tivdak by Genmab were $8 million in the first nine months of 2025 with no net product
sales in the first nine months of 2024. Tivdak was approved in Japan in May 2025 and became available for
prescribing in Germany in September 2025.
Refer to Financial Statement Note 3 in this interim report for further details about revenue.
Key Developments to Revenue – Third Quarter of 2025
Genmab’s revenue was $1,022 million for the third quarter of 2025 compared to $816 million for the third
quarter of 2024. The increase of $206 million, or 25%, was primarily driven by higher DARZALEX and Kesimpta
royalties achieved under our collaborations with J&J and Novartis, respectively, increased EPKINLY net product
sales, and increased milestones achieved under our collaborations with AbbVie, J&J and Novo Nordisk,
respectively, partly offset by reduced reimbursement revenue associated with Genmab assuming full control of
development, as well as future commercialization, of the acasunlimab program, effective in the second half of
2024.
Royalties
Royalty revenue on net sales of DARZALEX was $656 million in the third quarter of 2025 compared to $557
million in the third quarter of 2024, an increase of $99 million, or 18%. Royalty revenue on net sales of Kesimpta
was $122 million  in the third quarter of 2025 compared to $84 million in the third quarter of 2024, an increase of
$38 million, or 45%.
Net Product Sales
Global net sales of EPKINLY/TEPKINLY were $122 million in the third quarter of 2025, compared to $82 million
in the third quarter of 2024, an increase of $40 million or 49%.
Net product sales of Tivdak recorded by Genmab were $7 million in the third quarter of 2025 with no net product
sales in the third quarter of 2024.
Reimbursement Revenue
Reimbursement revenue amounted to $7 million in the third quarter of 2025 compared to $39 million in the third
quarter of 2024, a decrease of $32 million or 82%.
Cost of Product Sales
Genmab recognized cost of product sales of $157 million in the first nine months of 2025 compared to $95
million in the first nine months of 2024. Cost of product sales includes product costs, royalty expense and profit-
sharing amounts payable to AbbVie. The profit-sharing amount paid to AbbVie related to EPKINLY was $128
million in the first nine months of 2025.
Key Developments to Cost of Product Sales – Third Quarter of 2025
Cost of product sales were $58 million for the third quarter of 2025 compared to $40 million for the third quarter
of 2024. Cost of product sales includes product costs, royalty expense and profit-sharing amounts payable to
AbbVie. The profit-sharing amount paid to AbbVie related to EPKINLY was $46 million in the third quarter of
2025.
Research and Development Expenses
Research and development expenses amounted to $1,080 million in the first nine months of 2025 compared to 
$1,032 million in the first nine months of 2024. The increase of $48 million, or 5%, was driven by the addition of
ProfoundBio related research and development expenses, primarily Rina-S, and the increase in team members
to support the continued expansion of our product portfolio. The acquisition of ProfoundBio occurred in the
second quarter of 2024 and therefore there were minimal ProfoundBio related research and development
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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Interim Report for the Nine Months of 2025
expenses during the first nine months of 2024. These increases were partly offset by decreased research and
development expenses related to Epcoritamab under our collaboration with AbbVie, primarily due to  lower CMC
costs in the first nine months of 2025 compared to the first nine months of 2024.
Research and development expenses accounted for 72% of total research and development expenses &
selling, general and administrative expenses in the first nine months of 2025 compared to 74% in the first nine
months of 2024.
Key Developments to Research and Development Expenses – Third Quarter of 2025
Research and development expenses were $357 million for the third quarter of 2025 compared to $336 million
for the third quarter of 2024, an increase of $21 million, or 6%.
Selling, General and Administrative Expenses
Selling, general and administrative expenses were $418 million in the first nine months of 2025 compared to
$370 million in the first nine months of 2024. The increase of $48 million, or 13%, was driven primarily by the
expansion of Genmab’s global commercialization capabilities, primarily associated with the expansion of
Epcoritamab and investment in commercialization related activities for Rina-S to prepare for the upcoming
projected launch.
Selling, general and administrative expenses accounted for 28% of total research and development expenses &
selling, general and administrative expenses in the first nine months of 2025 compared to 26% for the first nine
months of 2024.
Key Developments to Selling, General and Administrative Expenses – Third Quarter of 2025
Selling, general and administrative expenses were $148 million for the third quarter of 2025 compared to $127
million for the third quarter of 2024. The increase of $21 million, or 17%, was driven primarily by the expansion
of Genmab’s European commercialization capabilities.
Acquisition and Integration Related Charges
Acquisition and integration related charges for the acquisition of ProfoundBio were $39 million in the first nine
months of 2024. There were no acquisition and integration related charges in the first nine months of 2025.
Key Developments to Acquisition and Integration Related Charges – Third Quarter of 2025
Acquisition and integration related charges for the acquisition of ProfoundBio were $ 3 million for the third
quarter of 2024. There were no acquisition and integration related charges for the third quarter of 2025.
Operating Profit
Operating profit was $1,007 million in the first nine months of 2025 compared to $662 million in the first nine
months of 2024. The increase was driven by the items described above.
Key Developments to Operating Profit - Third Quarter of 2025
Operating profit was $ 459 million for the third quarter of 2025 compared to $310 million for the third quarter of
2024. The increase was driven by the items described above.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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Interim Report for the Nine Months of 2025
Net Financial Items
Financial income and expense was comprised of the following:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2025
2024
2025
2024
Interest and other financial income
$32
$24
$90
$112
Gain on marketable securities
18
20
87
139
Gain on other investments, net
5
Foreign exchange rate gain
10
135
72
Total financial income
$60
$44
$312
$328
Interest and other financial expenses
$(3)
$(3)
$(17)
$(10)
Loss on marketable securities
(12)
(82)
(24)
(131)
Loss on other investments, net
(2)
(1)
Foreign exchange rate loss
(20)
(16)
(128)
(40)
Total financial expenses
$(37)
$(101)
$(170)
$(181)
Net financial items
$23
$(57)
$142
$147
Interest and Other Financial Income
Interest and other financial income was $90 million in the first nine months of 2025 compared to $112 million in
the first nine months of 2024. The decrease of $22 million was primarily driven by lower average cash and cash
equivalents and marketable securities as a result of the ProfoundBio acquisition in the second quarter of 2024,
as well as lower interest rates on USD denominated marketable securities in the first nine months of 2025
compared to the first nine months of 2024.
Gain on Marketable Securities, Net
Gain on marketable securities, net, which includes the impact of foreign exchange rate movements, totaled $63
million for the first nine months of 2025, compared to $8 million for the same period in 2024. The increase was
primarily driven by the change in the functional currency of Genmab A/S effective January 1, 2025. As the
majority of Genmab’s investment portfolio is denominated in U.S. dollars, these securities were adversely
affected by the weakening of the USD against the DKK during the first nine months of 2024. In contrast, during
the first nine months of 2025, Genmab’s DKK and EUR denominated securities benefited from the
strengthening of those currencies against the USD, resulting in a higher overall gain on marketable securities.
Foreign Exchange Rate Gain, Net
Foreign exchange rate gain, net, which excludes foreign exchange rate movements on marketable securities,
was $7 million in the first nine months of 2025 compared to foreign exchange rate gain, net of $32 million in the
first nine months of 2024. The decrease in foreign exchange rate gain, net is primarily driven by a lower foreign
exchange rate impact due to the change in functional currency of Genmab A/S from DKK to USD on January 1,
2025.
Refer to Financial Statement Note 1 and Note 6 in this interim report for further details about the net financial
items.
Key Developments to Net Financial Items – Third Quarter of 2025
Interest and Other Financial Income
Interest and other financial income was $32 million for the third quarter of 2025 compared to $24 million for the
third quarter of 2024. The increase of $8 million was primarily driven by higher cash and cash equivalents and
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
marketable securities in the third quarter of 2025 compared to the third quarter of 2024, due to the ProfoundBio
acquisition in the second quarter of 2024.
Marketable Securities
Gain on Marketable Securities, net which includes the impact of foreign exchange rate movements, was $6
million for the third quarter of 2025 compared to a loss on marketable securities, net of $62 million for the third
quarter of 2024. As the majority of Genmab’s investment portfolio is denominated in U.S. dollars, these
securities were adversely affected by the weakening of the USD against the DKK during the third quarter of
2024. In contrast, during the third quarter of 2025, Genmab’s DKK and EUR denominated securities benefited
from the strengthening of those currencies against the USD, resulting in a gain on marketable securities.
Corporate Tax
Corporate tax expense for the first nine months of 2025 was $217 million compared to $228 million for the first
nine months of 2024. The decrease in corporate tax expense is primarily the result of Genmab’s lower
estimated annual effective tax rate in the first nine months of 2025 of 18.9% compared to 28.1% in the first nine
months of 2024.
Key Developments to Corporate Tax – Third Quarter of 2025
Corporate tax expense for the third quarter of 2025 was $81 million compared to $67 million for the third quarter
of 2024. The increase in corporate tax expense is primarily the result of Genmab’s higher net profit before tax,
partly offset by Genmab’s lower estimated annual effective tax rate for the third quarter of 2025 of 18.9%
compared to 28.1% in the third quarter of 2024.
Net Profit
Net profit for the first nine months of 2025 was $932 million compared to $581 million in the first nine months of
2024. The increase was driven by the items described above.
Liquidity and Capital Resources
September
30, 2025
December
31, 2024
Marketable securities
$1,650
$1,574
Cash and cash equivalents
$1,761
$1,380
Shareholders' equity
$5,751
$5,137
Nine Months Ended September 30,
2025
2024
Change
Net cash provided by operating activities
$885
$737
$148
Net cash (used in) investing activities
$(71)
$(1,459)
$1,388
Net cash (used in) financing activities
$(440)
$(564)
$124
Increase (decrease) in cash and cash equivalents
$374
$(1,286)
$1,660
Exchange Rate adjustments
$7
$34
$(27)
Net cash provided by operating activities is primarily related to our operating profit, changes in operating assets
and liabilities, reversal of net financial items, and adjustments related to non-cash transactions. The $148 million
increase in net cash provided by operating activities is primarily driven by a $340 million increase in net profit
before tax and a $69 million increase related to changes in receivables and other current assets, partly offset by
an increase in corporate taxes paid of $268 million.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Net cash used in investing activities primarily reflects differences between the proceeds received from the sale
and maturity of our investments and amounts invested, and the cash paid for investments in tangible and
intangible assets. The $1,388 million decrease in net cash used in investing activities is primarily driven by the
acquisition of ProfoundBio during the second quarter of 2024, partly offset by the sales and maturities of
marketable securities exceeding purchases in the first nine months of 2024 compared to purchases of
marketable securities exceeding sales and maturities during the first nine months of 2025.
Net cash used in financing activities is primarily related to the purchase of treasury shares, exercise of warrants,
lease payments, and payment of withholding taxes on behalf of employees on net settled Restricted Stock Units
(RSUs). The $124 million decrease in net cash used in financing activities between the periods is primarily
driven by $130 million decreased cash paid for the purchase of treasury shares during the first nine months of
2025 compared to the first nine months of 2024 due to the timing of share repurchases. This decrease was
partly offset by lower proceeds from the exercise of warrants of $2 million, with $16 million received in the first
nine months of 2025 as compared to $18 million in the first nine months of 2024.
Genmab’s USD denominated marketable securities represented 75% of Genmab’s total marketable securities
as of September 30, 2025, compared to 76% as of December 31, 2024.
Cash and cash equivalents included short-term marketable securities of $140 million as of September 30, 2025,
compared to $11 million as of December 31, 2024. In accordance with our accounting policy, securities
purchased with a maturity of less than ninety days at the date of acquisition are classified as cash and cash
equivalents.
Refer to Note 5 -  Financial Instruments in this interim report for further details about our marketable securities.
Balance Sheet
As of September 30, 2025, total assets were $7,021 million compared to $6,414 million on December 31, 2024 .
The increase of $607 million, or 9% was primarily driven by an increase in cash and cash equivalents of $381
million due to the continued rebuild of Genmab’s cash post acquisition of ProfoundBio in May 2024 and an
increase in current receivables of $123 million due to higher DARZALEX and Kesimpta royalties achieved under
our collaborations with J&J and Novartis, respectively in Q3 2025 as compared to Q4 2024. As of  September
30, 2025, assets were mainly comprised of $355 million of goodwill and $1,748 million of other intangible
assets, primarily made up of assets acquired in the ProfoundBio acquisition, marketable securities of $1,650
million, current receivables of $1,046 million, and cash and cash equivalents of $1,761 million. The current
receivables consist primarily of amounts related to royalties from our collaboration agreements.
As of September 30, 2025, total liabilities were $1,270 million compared to $1,277 million on December 31,
2024. The decrease in total liabilities of $7 million was primarily driven by a decrease of $119 million in
corporate taxes payable primarily due to Genmab’s lower annual effective tax rate, partially offset by an
increase in current other payables of $113 million, primarily related to accruals related to the expansion of our
product pipeline.
Shareholders’ equity as of September 30, 2025, was $5,751 million compared to $5,137 million on December
31, 2024. The increase of $614 million, or 12%, was primarily driven by Genmab’s net profit for the period and
share-based compensation expenses, partly offset by the purchase of treasury shares. Genmab’s equity ratio
increased to 82% as of September 30, 2025 compared to 80% as of December 31, 2024.
Team Members
As of September 30, 2025, the total number of team members was 2,681 compared to 2,635 as of September
30, 2024. The increase was primarily driven by the continued expansion of our product portfolio, as well as the
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
investment in the expansion of Genmab’s global commercialization capabilities, including continued support for
EPKINLY in the U.S. and Japan post launch activities, and broader organizational capabilities.
Nine Months Ended
September 30,
Team Members
2025
2024
Research and development team members
1,841
1,853
Selling, general and administrative team members
840
782
Total team members
2,681
2,635
Legal Matters
Chugai Patent Infringement Complaint
In 2024, Chugai filed a lawsuit in the Tokyo District Court in Japan against AbbVie’s and Genmab’s Japanese
subsidiaries asserting that their activities related to EPKINLY (epcoritamab) in Japan infringe two Japanese
patents held by Chugai and claiming damages and injunctive relief. In September 2025, Chugai filed two further
lawsuits in the same court, against the same parties and with similar assertions, based on two newly granted
Japanese patents held by Chugai which are similar to the patents from the original lawsuit.
Genmab and AbbVie believe that all four of the patents are invalid and/or not infringed and intend to vigorously
defend the claims, and thus no provision has been recorded related to this matter.
AbbVie Rina-S Trade Secret Complaint
During the first quarter of 2025, AbbVie filed a complaint in the U.S. District Court for the Western District of
Washington (Seattle) naming Genmab A/S; ProfoundBio US Co.; ProfoundBio (Suzhou) Co., Ltd.; and former
AbbVie employees as defendants. AbbVie alleges that the defendants have misappropriated AbbVie’s alleged
trade secrets relating to the use of disaccharides to improve the hydrophilicity of drug-linkers in ADCs in
connection with Rina-S and other ADC pipeline products of ProfoundBio. AbbVie is seeking damages and broad
injunctive reliefs. AbbVie is not asserting or enforcing any patent rights against the defendants, and to
Genmab’s knowledge, AbbVie has not pursued any development of products incorporating their alleged trade
secrets.
Genmab categorically refutes these allegations and will vigorously defend the company against AbbVie’s
claims, and thus no provision has been recorded related to this matter.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME
Three Months Ended
September 30,
Nine Months Ended
September 30,
(USD million)
Note
2025
2024*
Restated
2025
2024*
Restated
Revenue
3
$1,022
$816
$2,662
$2,198
Cost of product sales
(58)
(40)
(157)
(95)
Research and development expenses
(357)
(336)
(1,080)
(1,032)
Selling, general and administrative expenses
(148)
(127)
(418)
(370)
Acquisition and integration related charges
2
(3)
(39)
Total costs and operating expenses
$(563)
$(506)
$(1,655)
$(1,536)
Operating profit
$459
$310
$1,007
$662
Financial income
6
60
44
312
328
Financial expenses
6
(37)
(101)
(170)
(181)
Net profit before tax
$482
$253
$1,149
$809
Corporate tax
(81)
(67)
(217)
(228)
Net profit
$401
$186
$932
$581
Other comprehensive income:
Amounts which may be re-classified to the income
statement:
Exchange differences on translation of foreign operations
6
129
22
3
Total comprehensive income
$407
$315
$954
$584
Basic net profit per share
$6.51
$2.94
$14.95
$9.04
Diluted net profit per share
$6.46
$2.92
$14.90
$8.99
*Effective January 1, 2025, the Company changed its presentation currency from DKK to USD. Accordingly, prior year balances have been
re-presented retrospectively. Refer to Note 1 for more information.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
CONDENSED CONSOLIDATED BALANCE SHEETS
September 30,
2025
December 31,
2024*
Restated
(USD million)
Note
ASSETS
Goodwill
4
$355
$355
Other intangible assets
4
1,748
1,728
Property and equipment
145
137
Right-of-use assets
9
121
128
Receivables
9
7
Deferred tax assets
127
127
Other investments
5
36
32
Other non-current assets
2
9
Total non-current assets
$2,550
$2,514
Corporate tax receivable
14
Inventories
14
9
Receivables
1,046
923
Marketable securities
5
1,650
1,574
Cash and cash equivalents
1,761
1,380
Total current assets
$4,471
$3,900
Total assets
$7,021
$6,414
SHAREHOLDERS’ EQUITY AND LIABILITIES
Share capital
10
10
Share premium
1,913
1,961
Other reserves
(204)
(226)
Retained earnings
4,032
3,392
Total shareholders' equity
$5,751
$5,137
Lease liabilities
9
126
131
Contract liabilities
3
67
67
Deferred tax liabilities
330
330
Other payables
6
5
Total non-current liabilities
$529
$533
Corporate tax payable
120
239
Lease liabilities
9
16
13
Contract liabilities
3
3
3
Other payables
602
489
Total current liabilities
$741
$744
Total liabilities
$1,270
$1,277
Total shareholders' equity and liabilities
$7,021
$6,414
Share-based payments
7
Related parties
8
Contingencies
10
Subsequent events to the balance sheet date
11
*Effective January 1, 2025, the Company changed its presentation currency from DKK to USD. Accordingly, prior year balances have been
re-presented retrospectively. Refer to Note 1 for more information.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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Interim Report for the Nine Months of 2025
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
Nine Months Ended
September 30,
(USD million)
Note
2025
2024*
Restated
Net profit before tax
$1,149
$809
Financial income
(312)
(328)
Financial expenses
170
181
Adjustments for non-cash transactions
Share-based compensation expense
7
92
78
Depreciation
39
36
Amortization
4
11
7
Impairment charges
4
1
11
Change in operating assets and liabilities:
Receivables
(124)
(193)
Inventories
(5)
(2)
Other payables
101
81
Cash flows from operating activities before financial items
$1,122
$680
Interest received
84
110
Interest elements of lease payments
9
(4)
(4)
Corporate taxes paid
(317)
(49)
Net cash provided by operating activities
$885
$737
Acquisition of business, net of cash acquired
(1,783)
Investment in intangible assets
4
(18)
(2)
Investment in tangible assets
(24)
(13)
Marketable securities bought
(956)
(1,040)
Marketable securities sold
930
1,384
Other investments bought
(3)
(5)
Net cash (used in) investing activities
$(71)
$(1,459)
Warrants exercised
16
18
Principal elements of lease payments
(11)
(8)
Purchase of treasury shares
7
(430)
(560)
Payment of withholding taxes on behalf of employees on net settled RSUs
(15)
(14)
Net cash (used in) financing activities
$(440)
$(564)
Change in cash and cash equivalents
$374
$(1,286)
Cash and cash equivalents at the beginning of the period
1,380
2,204
Exchange rate adjustments
7
34
Cash and cash equivalents at the end of the period
$1,761
$952
Cash and cash equivalents include:
Bank deposits
1,621
909
Short-term marketable securities
140
43
Cash and cash equivalents at the end of the period
$1,761
$952
*Effective January 1, 2025, the Company changed its presentation currency from DKK to USD. Accordingly, prior year balances have been
re-presented retrospectively. Refer to Note 1 for more information.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY*
Share
Share
Translation
Retained
Shareholders'
(USD million)
Note
capital
premium
reserves
earnings
equity
Balance at December 31, 2023
$10
$1,942
$(2)
$2,737
$4,687
Net profit
581
581
Other comprehensive income
3
3
Total comprehensive income
$
$
$3
$581
$584
Transactions with owners:
Exercise of warrants
18
18
Purchase of treasury shares
(560)
(560)
Share-based compensation expenses
78
78
Withholding taxes on behalf of
employees on net settled RSUs
(14)
(14)
Balance at September 30, 2024
$10
$1,960
$1
$2,822
$4,793
Balance at December 31, 2024
$10
$1,961
$(226)
$3,392
$5,137
Net profit
932
932
Other comprehensive income
22
22
Total comprehensive income
22
932
954
Transactions with owners:
  
  
  
  
  
Exercise of warrants
7
16
16
Purchase of treasury shares
7
(430)
(430)
Share-based compensation expenses
7
89
89
Share capital reduction
7
(64)
64
Withholding taxes on behalf of
employees on net settled RSUs
(15)
(15)
Balance at September 30, 2025
$10
$1,913
$(204)
$4,032
$5,751
*Effective January 1, 2025, the Company changed its presentation currency from DKK to USD. Accordingly, prior year balances have been
re-presented retrospectively. Refer to Note 1 for more information.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 28/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
NOTES TO THE CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
Note 1 -  Basis of Presentation
Accounting Policies
These interim financial statements of the Genmab Group (Genmab or the Company) have been prepared in
accordance with IAS 34 (Interim Financial Reporting) as issued by the International Accounting Standards
Board (IASB) and in accordance with IAS 34 as endorsed by the European Union (EU) and additional Danish
disclosure requirements for interim reports of listed companies. The interim report has not been audited or
reviewed by Genmab’s external auditors.
The interim report has been prepared using the same accounting policies as outlined in Section 1 – Basis of
Presentation in the financial statements in the Genmab 2024 Annual Report (Annual Report), except as noted
below. A number of amended standards became applicable for the current reporting period. There was no
impact to Genmab’s financial statements as a result of adopting these amended standards. These interim
financial statements should be read in conjunction with the Annual Report.
Functional and Presentation Currency Change
Management determined it is appropriate to change both the functional currency of the Genmab A/S legal entity
and the presentation currency of the condensed consolidated financial statements from DKK to USD effective
January 1, 2025. The change in functional currency was triggered by the commercialization of EPKINLY and
was made to reflect that USD has become the predominant currency of the Genmab A/S legal entity. The
change has been implemented with prospective effect. The change in presentation currency is applied
retrospectively and was made to better reflect the Company’s financial position. Comparative figures for prior
periods have been restated accordingly.
The condensed consolidated statements of comprehensive income and the condensed consolidated statements
of cash flows have been translated into the presentation currency using the average exchange rates prevailing
during each reporting period. In the condensed consolidated balance sheets, all assets and liabilities have been
translated using the period-end exchange rates, and all resulting exchange differences have been recognized in
accumulated other comprehensive income. Shareholders’ equity balances have been translated using historical
rates in effect on the date of the transactions. The DKK/USD exchange rates used to reflect the change in
presentation currency were as follows:
Q1 2024
Q2 2024
Q3 2024
Q4 2024
Average rate
0.1456
0.1443
0.1472
0.1433
Closing rate
0.1450
0.1435
0.1502
0.1400
The change in presentation currency resulted in the following impact on the December 31, 2024 condensed
consolidated balance sheets:
Previously reported in DKK
Reported in USD
December 31, 2024
Presentation currency
change
December 31, 2024
Total assets
45,811
(39,397)
6,414
Total liabilities
9,114
(7,837)
1,277
Total shareholders' equity
36,697
(31,560)
5,137
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 29/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
The change in presentation currency resulted in the following impact on the three months ended September 30,
2024 condensed consolidated statements of comprehensive income:
Previously reported in DKK
Reported in USD
September 30, 2024
Presentation currency
change
September 30, 2024
Net profit
1,266
(1,080)
186
Comprehensive income
686
(371)
315
The change in presentation currency resulted in the following impact on the nine months ended September 30,
2024 condensed consolidated statements of comprehensive income:
Previously reported in DKK
Reported in USD
September 30, 2024
Presentation currency
change
September 30, 2024
Net profit
3,999
(3,418)
581
Comprehensive income
3,593
(3,009)
584
The change in presentation currency resulted in the following impact on the nine months ended September 30,
2024 condensed consolidated statements of cash flows:
Previously reported in DKK
Reported in USD
Cash provided by (used in):
September 30, 2024
Presentation currency
change
September 30, 2024
Operating activities
5,059
(4,322)
737
Investing activities
(9,989)
8,530
(1,459)
Financing activities
(3,922)
3,358
(564)
The change in presentation currency resulted in the following impact on the three months ended September 30,
2024 basic and diluted earnings per share:
Previously reported in DKK
Reported in USD
September 30, 2024
Presentation currency
change
September 30, 2024
Earnings per share - basic
19.94
(17.00)
2.94
Earnings per share - diluted
19.81
(16.89)
2.92
The change in presentation currency resulted in the following impact on the nine months ended September 30,
2024 basic and diluted earnings per share:
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 30/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Previously reported in DKK
Reported in USD
September 30, 2024
Presentation currency
change
September 30, 2024
Earnings per share - basic
62.09
(53.05)
9.04
Earnings per share - diluted
61.72
(52.73)
8.99
Information about Geographical Areas
Genmab is managed and operated as one business unit, which is reflected in the organizational structure and
internal reporting. No separate lines of business or separate business entities have been identified with respect
to any licensed products, product candidates, product sales or geographical markets and no segment
information is currently prepared for internal reporting. Refer to Note 2.2 in the Annual Report for further details.
Reclassifications
In order to conform to the current period gross presentation for the first nine months of 2025, a reclassification
of net $24 million has been made to the gross amounts presented for the first nine months of 2024 to move
foreign exchange rate gains and losses related to marketable securities from gains and losses on foreign
exchange rates to gains and losses on marketable securities. These reclassifications have no impact on the net
amounts of financial items as presented in Note 6 -  Financial Income and Expenses.
(In all accompanying tables, amounts of dollars expressed in millions, except per share amounts, unless
otherwise noted.)
Note 2 -  Acquisitions
ProfoundBio
On May 21, 2024 (Acquisition Date), Genmab completed the acquisition of all of the outstanding shares of
ProfoundBio, resulting in ProfoundBio becoming a wholly owned subsidiary of Genmab. The acquisition of
ProfoundBio gave Genmab worldwide rights to three candidates in clinical development, including
ProfoundBio’s lead drug candidate, rinatabart sesutecan (Rina-S). In addition, Genmab acquired ProfoundBio’s
novel ADC technology platforms. Rina-S is a clinical-stage, FRα-targeted, TOPO1 ADC, which was in Phase 2
of a Phase 1/2 clinical trial at the time of the acquisition, for the treatment of ovarian cancer and other FRα-
expressing solid tumors. Based on the data from the ongoing Phase 1/2 clinical trial Genmab intends to
broaden the development plans for Rina-S within ovarian cancer and other FRα-expressing solid tumors. In
January 2024, the U.S. FDA granted Fast Track designation to Rina-S for the treatment of patients with FRα-
expressing high-grade serous or endometrioid platinum-resistant ovarian cancer.
In addition to payment of $1.72 billion for all of the outstanding shares of ProfoundBio, Genmab also made a
$199 million payment to holders of outstanding ProfoundBio equity awards for settlement of such vested and
non-vested awards. Of the USD $199 million payment, $187 million related to the portion of awards where the
vesting period was completed prior to the Acquisition Date. This portion of the payment was therefore
determined to be attributable to the pre-combination period and included in purchase consideration. The
remaining $11 million payment related to the portion of awards with future vesting conditions, and therefore is
attributable to post-combination services. The amount attributable to the post-combination service does not form
part of the consideration and was therefore instead recognized as Acquisition and integration related charges in
Genmab’s Condensed Consolidated Statements of Comprehensive Income during the second quarter of 2024.
The acquisition has been accounted for using the acquisition method of accounting which requires that assets
acquired and liabilities assumed be recognized at their fair values as of the Acquisition Date and consolidated
into Genmab’s Condensed Consolidated Balance Sheets. The results of operations for ProfoundBio have been
included in Genmab’s consolidated financial statements from the Acquisition Date. A fair value measurement
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 31/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
has been performed and the purchase price has been allocated to intangible assets, associated deferred tax
liabilities, other assets and liabilities, as well as goodwill being the excess value of the purchase price over the
fair value of assets acquired and liabilities assumed (the purchase price allocation). Adjustments may be applied
to the purchase price allocation for a period of up to 12 months from the Acquisition Date and was therefore
finalized during the second quarter of 2025. During the fourth quarter of 2024, the Company recorded a
measurement period adjustment impacting non-current deferred tax liabilities and goodwill that was not
material.
The total consideration for the acquisition of ProfoundBio is summarized as follows:
Total
Consideration
Cash paid for outstanding shares
$1,718
Cash for equity compensation attributable to pre-combination service
187
Total consideration
$1,905
Cash acquired
(122)
Cash used for acquisition of business
$1,783
The purchase price allocation resulted in the following amounts being allocated to the assets acquired and
liabilities assumed at the Acquisition Date based upon their respective fair values summarized below:
Amounts
Recognized as of
the Acquisition Date
Cash and cash equivalents
$122
Other current assets*
4
Property and equipment
6
IPR&D
1,540
Technology platform intangible asset
181
Other non-current assets**
3
Non-current deferred tax liability
(292)
Other current liabilities***
(13)
Total identifiable net assets
$1,551
Goodwill
354
Total consideration
$1,905
* Includes receivables and other investments
** Includes other investments and right-of-use assets
*** Includes other payables, contract liabilities, lease and other liabilities
The carrying values of other current assets, property and equipment, other non-current assets and other current
liabilities were determined to approximate their fair values.
The fair value assigned to acquired IPR&D, which was calculated using the multi-period excess earnings
method of the income approach, was based on the present value of expected after-tax cash flows attributable to
Rina-S, which was in Phase 1/2 testing. The present value of expected after-tax cash flows obtainable from
Rina-S and assigned to IPR&D was determined by estimating the after-tax costs to complete development of
Rina-S into a commercially viable product, estimating future revenue and ongoing expenses to produce, support
and sell Rina-S, on an after-tax basis, and discounting the resulting net cash flows to present value. The
revenue and costs projections used were reduced based on the probability that compounds at similar stages of
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 32/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
development will become commercially viable products. The rate utilized to discount the net cash flows to their
present value reflects the risk associated with the future earnings attributable to the intangible asset. Acquired
IPR&D will be accounted for as an intangible asset not yet available for use until regulatory approval in a major
market is received or development is discontinued.
The fair value of the technology platform intangible asset was calculated using the relief from royalty method of
the income approach. This method includes assigning value based on the economic savings from owning,
rather than in-licensing, the technology platform intangible asset supported by observable market data for peer
companies, then discounting the resulting probability adjusted net post-tax cash flows using a discount rate
commensurate with the risk associated with the future income or cost savings attributable to the intangible
asset.
The significant assumptions used to estimate the value of the acquired intangible assets include discount rates
and certain assumptions that form the basis of future cash flows (such as probabilities of technical and
commercial success, revenue growth rates, operating margins, and royalty rates). 
The excess of purchase price over the fair value amounts assigned to identifiable assets acquired and liabilities
assumed represents the goodwill amount resulting from the acquisition. The goodwill recorded as part of the
acquisition is attributable to the intangible assets that do not qualify for separate recognition at the time of the
acquisition, assembled workforce and deferred tax consequences of the IPR&D and technology platform
intangible asset recorded for financial statement purposes. Genmab does not expect any portion of this goodwill
to be deductible for tax purposes. The goodwill attributable to the acquisition has been recorded as a non-
current asset in Genmab’s Condensed Consolidated Balance Sheets and is not amortized, but is subject to
review for impairment annually. Refer to Note 4 for further details related to the accounting for goodwill.
From the Acquisition Date through September 30, 2024, Genmab’s Condensed Consolidated Statements of
Comprehensive Income include no revenue and the following expenses associated with the acquisition and
operations of ProfoundBio:
Condensed Consolidated Statements of Comprehensive Income:
Acquisition Date
through September
30, 2024
Research and development expenses
$30
Selling, general and administrative expenses
2
Acquisition and integration related charges*
23
Total
$55
* Acquisition related charges incurred from the Acquisition Date through September 30, 2024, are comprised of
payments to holders of outstanding ProfoundBio equity awards related to post-combination services
($11 million). The remaining expenses are integration related charges incurred from the Acquisition Date
through September 30, 2024, which are comprised of professional fees incurred to assist with the integration
of ProfoundBio into Genmab’s operations post-acquisition. Additionally, prior to the Acquisition Date, Genmab
recorded $16 million in Acquisition and integration related charges in Genmab’s Condensed Consolidated
Statements of Comprehensive Income related to professional due diligence procedures in connection with the
acquisition of ProfoundBio. The $16 million of Acquisition and integration related charges incurred prior to the
Acquisition Date and the $23 million of Acquisition and integration charges incurred from the Acquisition Date
through September 30, 2024 total $39 million.
The following table provides Genmab’s consolidated revenue and net profit for the first nine months of 2024 as
if the acquisition of ProfoundBio had occurred on January 1, 2024:
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 33/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Nine Month Period
Ended September
30, 2024
Revenue
$2,198
Net Profit
$550
The unaudited pro forma information does not necessarily reflect the actual results of operations of the
combined entities that would have been achieved, nor are they necessarily indicative of future results of
operations. The unaudited pro forma information reflects certain adjustments that were directly attributable to
the acquisition of ProfoundBio, including additional amortization adjustments for the fair value of the technology
platform intangible asset acquired.
As of September 30, 2024, Cash and cash equivalents in Genmab’s Condensed Consolidated Balance Sheets
includes $30 million of restricted cash balances for funds held in escrow related to the acquisition of
ProfoundBio.
Merus
On September 29, 2025, Genmab entered into a transaction agreement for the acquisition of all the shares of
Merus, a clinical-stage biotechnology company with its late-stage breakthrough therapy asset petosemtamab
(Peto), which is in Phase 3 development, for $97 per share in an all-cash transaction representing a transaction
value of approximately $8.0 billion. The transaction has been unanimously approved by the Boards of Directors
of both companies. During the fourth quarter of 2025, Genmab will commence a tender offer for 100% of Merus’
common shares. The closing of the transaction is subject to the satisfaction of customary closing conditions for
similar transactions and the acquisition is anticipated to close by early in the first quarter of 2026. The
transaction, which is not subject to a financing condition, is expected to be funded through a combination of
cash on hand and approximately $5.5 billion of non-convertible debt financing. Genmab has obtained a funding
commitment from Morgan Stanley Senior Funding, Inc. for this amount.
It is anticipated that upon closing, this transaction will be accounted for by Genmab as an asset acquisition as
substantially all of the fair value of the acquired set of assets is anticipated to be concentrated in a single
identifiable asset (i.e. Peto).
Acquisition-related costs incurred in connection with an asset acquisition are capitalized as part of the purchase
price and allocated based on relative fair value to the net assets acquired. As of September 30, 2025, Other
non-current assets in Genmab’s Condensed Consolidated Balance Sheets includes $9 million of acquisition 
costs related primarily to professional service fees in connection to the transaction. Upon closing of the asset
acquisition, such costs will be reclassified to the net assets acquired based on relative fair value.
Additionally, Genmab is anticipated to incur approximately $44 million of M&A transaction fees upon closing of
the transaction as well as approximately $91 million of fees related to the non-convertible debt financing. Such
costs have not been recorded in Genmab’s Condensed Consolidated Financial Statements as of September 30,
2025 as they have yet to be incurred. Upon closing of the transaction, it is anticipated that the M&A fees will be
capitalized as an acquisition transaction cost and the commitment fees will be recorded as a reduction to the
debt liability within Genmab’s Consolidated Balance Sheets.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Note 3 -  Revenue
The table below summarizes Genmab’s revenue by type and collaboration partner, and royalties by product,
under Genmab’s agreements.
Three Months Ended
September 30,
Nine Months Ended
September 30,
2025
2024
2025
2024
Revenue by type:
Royalties
$841
$691
$2,219
$1,802
Reimbursement revenue
7
39
43
121
Milestone revenue
53
1
66
51
Collaboration revenue
17
15
54
45
Net product sales
104
70
280
179
Total
$1,022
$816
$2,662
$2,198
Revenue by collaboration partner:
J&J
$694
$575
$1,831
$1,490
Roche
30
30
76
79
Novartis
122
84
322
229
BioNTech
4
34
34
108
Pfizer
19
19
60
56
AbbVie
36
4
44
57
Other
13
15
Total*
$918
$746
$2,382
$2,019
Royalties by product:
DARZALEX
$656
$557
$1,744
$1,442
Kesimpta
122
84
320
228
TEPEZZA
30
29
75
78
Other**
33
21
80
54
Total
$841
$691
$2,219
$1,802
* Excludes Genmab’s Net product sales
** Other consist of royalties from net sales of RYBREVANT, TECVAYLI, TALVEY and TEPKINLY.
Net Product Sales
Genmab recognized net product sales of $280 million during the first nine months of 2025 compared to $179
million in the first nine months of 2024. EPKINLY was approved in the U.S. in May 2023 and Japan in
September 2023.
Contract Liabilities
As part of the continued evaluation of contract liabilities related to the AbbVie Agreement, during the first nine
months of 2025, Genmab’s classification of contract liabilities reflects the current estimate of co-development
activities as of September 30, 2025. These co-development activities are related to a performance obligation in
connection with the product concepts under a research option agreement. Contract liabilities have been
recognized as reimbursement revenue during the first nine months of 2025.
Refer to Note 2.1 in the Annual Report for further details regarding revenue.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 35/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Note 4 -  Other Intangible Assets and Goodwill
Goodwill
Licenses
and Patents
Technology
Platform
Acquired
IPR&D
Total
Intangible
Assets
September 30, 2025
Cost at the beginning of the period
$355
$149
$180
$1,532
$2,216
Additions during the period
32
32
Cost at the end of the period
$355
$181
$180
$1,532
$2,248
Amortization and impairment losses at the
beginning of the period
126
7
133
Amortization for the period
2
9
11
Impairment losses for the period
1
1
Amortization and impairment losses at the
end of the period
129
16
145
Carrying amount at the end of the period
$355
$52
$164
$1,532
$2,103
December 31, 2024
Cost at the beginning of the year
$
$134
$
$
$134
Additions during the year
354
24
180
1,536
2,094
Effect of exchange rate adjustment
1
(9)
(4)
(12)
Cost at the end of the year
$355
$149
$180
$1,532
$2,216
Amortization and impairment losses at the
beginning of the year
119
119
Amortization for the year
3
8
11
Impairment losses for the year
11
11
Effect of exchange rate adjustment
(7)
(1)
(8)
Amortization and impairment losses at the
end of the year
126
7
133
Carrying amount at the end of the year
$355
$23
$173
$1,532
$2,083
Other Intangible Assets
The increase in the gross carrying value of other intangible assets during the first nine months of 2025 was due
to the addition of $32 million of licenses and patents.
Amortization expense was $11 million and $7 million for the first nine months of 2025 and 2024 respectively,
which was recorded in Research and development expenses in the Condensed Consolidated Statements of
Comprehensive Income.
Goodwill
The carrying amount of goodwill, which relates to the acquisition of ProfoundBio during the second quarter of
2024, was $355 million as of both September 30, 2025 and December 31, 2024.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 36/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Note 5 -  Financial Instruments
Genmab’s portfolio is spread over a number of different securities with a focus on liquidity and the preservation
of capital. Genmab’s marketable securities in USD, DKK, EUR, and GBP as a percentage of total marketable
securities were as follows:
September 30,
2025
December 31,
2024
Percent
USD
75
%
76
%
DKK
16
%
15
%
EUR
8
%
8
%
GBP
1
%
1
%
Total
100
%
100
%
As of September 30, 2025, 70% of Genmab’s marketable securities were long-term A rated or higher, or short-
term A-1 / P-1 rated compared to 71% as of December 31, 2024.
The table below shows the fair value measurements by level for Genmab’s financial assets measured at fair
value through profit or loss:
September 30, 2025
December 31, 2024
Assets Measured at Fair Value
Level 1
Level 2
Level 3
Total
Level 1
Level 2
Level 3
Total
Marketable securities
1,650
1,650
1,574
1,574
Other investments
8
2
26
36
5
2
25
32
Marketable Securities
All fair values are determined by reference to external sources using unadjusted quoted prices in established
markets for Genmab’s marketable securities (Level 1).
Other Investments
Other investments primarily consist of investments in certain strategic investment funds. Genmab’s share of the
fair value of these fund investments is determined based on the valuation of the underlying investments
included in the fund. Investments in publicly traded equity securities included in these strategic investment funds
are valued based at the most recent sale price or official closing price reported on the exchange or over-the-
counter market on which they trade, while investments in non-publicly traded equity securities are based on
other factors, including but not limited to, type of the security, the size of the holding, the initial cost of the
security, the price and extent of public trading in similar securities of the comparable companies, an analysis of
the company's or issuer's financial statements and with respect to debt securities, the maturity and
creditworthiness. As such, these fund investments have been characterized as Level 3 investments as fair
values are based on significant unobservable inputs.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
Page 37/43
CVR no. 2102 3884
Interim Report for the Nine Months of 2025
There were no transfers into or out of Level 3 during the first nine months of 2025 or 2024. Acquisitions (capital
calls) and fair value changes on Level 3 investments in 2025 and 2024 were as follows:
Other Investments
Fair value at December 31, 2023
13
Acquisitions
3
Fair value changes
5
Fair value at September 30, 2024
21
Acquisitions
3
Fair value changes
1
Fair value at December 31, 2024
25
Acquisitions
3
Fair value changes
(2)
Fair value at September 30, 2025
26
Refer to Note 4.3 and Note 4.4 in the Annual Report for further details regarding Genmab’s marketable
securities and other investments.
Note 6 -  Financial Income and Expenses
Three Months Ended
September 30,
Nine Months Ended
September 30,
2025
2024
2025
2024
Financial income:
Interest and other financial income
$32
$24
$90
$112
Gain on marketable securities
18
20
87
139
Gain on other investments, net
5
Foreign exchange rate gain
10
135
72
Total financial income
$60
$44
$312
$328
Financial expenses:
Interest and other financial expenses
$(3)
$(3)
$(17)
$(10)
Loss on marketable securities
(12)
(82)
(24)
(131)
Loss on other investments, net
(2)
(1)
Foreign exchange rate loss
(20)
(16)
(128)
(40)
Total financial expenses
$(37)
$(101)
$(170)
$(181)
Net financial items
$23
$(57)
$142
$147
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Note 7 -  Share-Based Payments
Restricted Stock Unit Program
Genmab has established an RSU program (equity-settled share-based payment transactions) as an incentive
for Genmab’s employees, members of the Executive Management, and members of the Board of Directors.
RSUs granted to Executive Management are performance-based (PSUs).
Nine Months Ended
September 30,
2025
2024
RSUs granted
651,178
476,439
Weighted average fair value per RSU granted (DKK)
1,607.47
1,989.31
RSUs vested
198,918
142,263
Refer to Note 4.6 in the Annual Report for details on the RSU program.
Warrant Program
Genmab has established a warrant program (equity-settled share-based payment transactions) as an incentive
for all Genmab employees.
Nine Months Ended
September 30,
2025
2024
Warrants granted
540,011
358,994
Weighted average exercise price per warrant granted (DKK)
1,609.25
1,990.64
Weighted average Black-Scholes fair value per warrant granted (DKK)
501.60
645.20
Warrants exercised
96,016
102,296
Weighted average exercise price on date of grant per warrant exercised (DKK)
1,069.78
1,151.81
% change in share capital - warrants exercised
0.15%
0.15%
Refer to Note 4.6 in the Annual Report for details on the warrant program.
Share-Based Compensation Expense
Share-based compensation expenses related to Genmab’s RSU and warrant programs for the first nine months
of 2025 were $92 million compared to $78 million for the first nine months of 2024.
Share Repurchases
At Genmab’s Annual General Meeting on March 12, 2025, the Board of Directors was authorized to allow
Genmab to acquire treasury shares with a total nominal value of up to 10% of the share capital in the period
until and including March 11, 2030. The purchase price for the relevant shares may not deviate by more than
10% from the price quoted on Nasdaq Copenhagen at the time of the acquisition. Such shares may only be
acquired to the extent that the Company’s total holding of treasury shares does not at any time exceed a
nominal value of 10% of the share capital. The authorization replaced existing previously provided
authorizations to purchase treasury shares.
As announced on March 25, 2025, Genmab initiated a share buy-back program to reduce capital and to honor
our commitments under the RSU program. During the first nine months of 2025, Genmab acquired 2,200,000 of
its own shares under the program, representing approximately 3.3% of share capital as of December 31, 2024.
The total amount incurred to acquire the shares, including directly attributable costs, was $430 million and was
recognized as a deduction to shareholders’ equity. These shares are classified as treasury shares and are
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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Interim Report for the Nine Months of 2025
presented within retained earnings on the Condensed Consolidated Balance Sheets as of September 30, 2025.
As of September 30, 2025, 3,781,534 shares were available for repurchase, and 2,639,101 treasury shares
were held by Genmab.
During the first nine months of 2024, Genmab acquired 2,011,853 of its own shares, under both programs,
representing approximately 3.0% of share capital as of December 31, 2023. The total amount incurred to
acquire the shares, including directly attributable costs, was $560 million and was recognized as a deduction to
shareholders’ equity.
Share Capital Reduction
At Genmab’s Annual General Meeting on March 12, 2025, the decision was made to reduce the share capital
with nominally DKK 2,076,853 by cancellation of 2,076,853 of the Company’s holding of shares with a nominal
value of DKK 1 each. On April 10, 2025, the capital reduction was registered with the Danish Business Authority.
Note 8 -  Related Parties
Genmab’s related parties are its Board of Directors, Executive Management, and close members of the family
of these persons.
Genmab has not granted any loans, guarantees or other commitments to or on behalf of any of the members of
the Board of Directors or members of the Executive Management.
Related party transactions include remuneration relating to the Board of Directors and the Executive
Management as described in Note 5.1 in the Annual Report.There were no material related party transactions
during the first nine months of 2025 or 2024.
Changes to the Executive Management and the Board of Directors
Following Genmab’s Annual General Meeting on March 12, 2025, the Board of Directors is comprised of five
independent board members, one non-independent board member, and three employee-elected board
members. Deirdre P. Connelly (Chair), Pernille Erenbjerg (Deputy Chair), Rolf Hoffmann, Elizabeth O’Farrell,
Paolo Paoletti and Anders Gersel Pedersen were re-elected to the Board of Directors for a one-year period.
Mijke Zachariasse, Martin Schultz and Michael Kavanagh were elected as employee-elected board members
and will serve for a three-year period expiring in 2028.
Effective July 1, 2025, Greg Mueller was appointed Genmab’s Executive Vice President, General Counsel and
Chief Legal Officer, following the retirement from Genmab of Birgitte Stephensen, former Executive Vice
President and Chief Legal Officer.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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Interim Report for the Nine Months of 2025
Note 9 -  Leases
Amounts recognized in the Condensed Consolidated Balance Sheets
The Condensed Consolidated Balance Sheets show the following amounts relating to leases:
September
30, 2025
December
31, 2024
Right-of-use assets
Properties
$121
$128
Total right-of-use assets
$121
$128
Lease liabilities
Current
$16
$13
Non-current
126
131
Total lease liabilities
$142
$144
During the first nine months of 2025, there were no material additions to Genmab’s right-of-use assets and
lease liabilities. During the first nine months of 2024, there were additions to Genmab’s right-of-use assets and
lease liabilities related to the commencement of leases in the U.S. with respect to office and laboratory space
and in Japan with respect to office space.
Amounts recognized in the Condensed Consolidated Statements of Comprehensive Income
The Condensed Consolidated Statements of Comprehensive Income show the following amounts relating to
leases:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2025
2024
2025
2024
Depreciation charge of right-of-use assets
Properties
$4
$4
$12
$11
Total depreciation charge of right-of-use assets
$4
$4
$12
$11
Variable lease payments, short-term lease expense, lease interest expense and low-value leases are not
material.
Note 10 -  Contingencies
Chugai Patent Infringement Complaint
In 2024, Chugai filed a lawsuit in the Tokyo District Court in Japan against AbbVie’s and Genmab’s Japanese
subsidiaries asserting that their activities related to EPKINLY (epcoritamab) in Japan infringe two Japanese
patents held by Chugai and claiming damages and injunctive relief. In September 2025, Chugai filed two further
lawsuits in the same court, against the same parties and with similar assertions, based on two newly granted
Japanese patents held by Chugai which are similar to the patents from the original lawsuit.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
Interim Report for the Nine Months of 2025
Genmab and AbbVie believe that all four of the patents are invalid and/or not infringed and intend to vigorously
defend the claims, and thus no provision has been recorded related to this matter.
AbbVie Rina-S Trade Secret Complaint
During the first quarter of 2025, AbbVie filed a complaint in the U.S. District Court for the Western District of
Washington (Seattle) naming Genmab A/S; ProfoundBio US Co.; ProfoundBio (Suzhou) Co., Ltd.; and former
AbbVie employees as defendants. AbbVie alleges that the defendants have misappropriated AbbVie’s alleged
trade secrets relating to the use of disaccharides to improve the hydrophilicity of drug-linkers in ADCs in
connection with Rina-S and other ADC pipeline products of ProfoundBio. AbbVie is seeking damages and broad
injunctive reliefs. AbbVie is not asserting or enforcing any patent rights against the defendants, and to
Genmab’s knowledge, AbbVie has not pursued any development of products incorporating their alleged trade
secrets.
Genmab categorically refutes these allegations and will vigorously defend the company against AbbVie’s
claims, and thus no provision has been recorded related to this matter.
Note 11 -  Subsequent Events to the Balance Sheet Date
On October 21, 2025, Genmab announced the commencement of the cash tender offer to purchase all of the
issued and outstanding common shares of Merus for $97 per share. The tender offer will expire on December
11, 2025 or may be extended pursuant to, and in accordance with, the terms of the Transaction Agreement
between Genmab and Merus. After completion of the tender offer, Genmab will commence a subsequent
offering period in which Genmab will offer to purchase additional common shares of Merus for $97 per share.
No other events have occurred subsequent to the balance sheet date that could significantly affect the financial
statements as of September 30, 2025.
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884
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ABOUT GENMAB
Genmab is an international biotechnology company with a core purpose of guiding its unstoppable team to strive toward improving the lives
of patients with innovative and differentiated antibody therapeutics. For more than 25 years, its passionate, innovative and collaborative
team has invented next-generation antibody technology platforms and leveraged translational, quantitative and data sciences, resulting in a
proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and
effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases
with knock-your-socks-off (KYSO) antibody medicines®.
Established in 1999, Genmab is headquartered in Copenhagen, Denmark, with international presence across North America, Europe and
Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X.
This Interim Report contains forward looking statements. The words “believe,” “expect,” “anticipate,” “intend” and “plan” and similar
expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance
expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially
include, among others, risks associated with preclinical and clinical development of products, uncertainties related to the outcome and
conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of
our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to
attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our
relationships with affiliated entities, changes and developments in technology which may render our products or technologies obsolete, and
other factors. For a further discussion of these risks, please refer to the risk management sections in Genmab’s most recent financial
reports, which are available on www.genmab.com and the risk factors included in Genmab’s most recent Annual Report on Form 20-F and
other filings with the U.S. Securities and Exchange Commission (SEC), which are available at www.sec.gov. Genmab does not undertake
any obligation to update or revise forward looking statements in this Interim Report nor to confirm such statements to reflect subsequent
events or circumstances after the date made or in relation to actual results, unless required by law.
Genmab A/S and/or its subsidiaries own the following trademarks: Genmab®; the Y-shaped Genmab logo®; Genmab in combination with
the Y-shaped Genmab logo®; HuMax®; DuoBody®; HexaBody®; DuoHexaBody®; HexElect®; KYSO®, ABBIL1TY™, RAINFOL™;
ProfoundBio™ and Rina-S® are trademarks of ProfoundBio, US, Co. and Genmab (Suzhou) Co., Ltd. Tivdak® is a trademark of Seagen
Inc.; EPCORE®, EPKINLY®, TEPKINLY® and their designs are trademarks of AbbVie Biotechnology Ltd.; Kesimpta® and Sensoready® are
trademarks of Novartis AG or its affiliates; DARZALEX®, DARZALEX FASPRO®, RYBREVANT®, TECVAYLI® and TALVEY® are trademarks
of Johnson & Johnson; TEPEZZA® is a trademark of Horizon Therapeutics Ireland DAC.
Interim Report for the Nine Months of 2025
DIRECTORS’ AND MANAGEMENT’S STATEMENT ON THE INTERIM REPORT
The Board of Directors and the registered members of Executive Management have today considered and
adopted the interim report of the Genmab Group for the nine months ended September 30, 2025.
The interim report has not been audited or reviewed by Genmab’s external auditors. The interim report is
prepared in accordance with IAS 34, “Interim Financial Reporting,” as issued by the IASB and in accordance
with IAS 34 as endorsed by the EU, and additional Danish disclosure requirements for interim reports of listed
companies.
We consider the applied accounting policies to be appropriate and, in our opinion, the interim report gives a true
and fair view of the assets and liabilities, financial position, results of operation and cash flows of the Group.
Furthermore, we consider the Management’s Review to give a true and fair account of the development in the
Group’s activities and financial affairs, results of operations and the Group’s financial position as a whole as well
as a description of the significant risks and uncertainties which the Group faces, as further described in this
report, our 2024 Annual Report and the Form 20-F filed with the U.S. Securities and Exchange Commission in
February 2025.
Copenhagen, 6 November 2025
Registered Members of Executive Management
gmab_20250508xex99d1004.jpg
gmab_20250508xex99d1005.jpg
Jan van de Winkel
(President & CEO)
Anthony Pagano
(Executive Vice President
& CFO)
Board of Directors
gmab_20250508xex99d1006.jpg
gmab_20250508xex99d1007.jpg
gmab_20250508xex99d1008.jpg
Deirdre P. Connelly
(Chair)
Pernille Erenbjerg
(Deputy Chair)
Anders Gersel Pedersen
gmab_20250508xex99d1009.jpg
gmab_20250508xex99d1010.jpg
gmab_20250508xex99d1011.jpg
Rolf Hoffmann
Paolo Paoletti
Elizabeth O’Farrell
gmab_20250508xex99d1012.jpg
gmab_20250508xex99d1013.jpg
gmab_20250508xex99d1014.jpg
Mijke Zachariasse
(Employee elected)
Michael Kavanagh
(Employee elected)
Martin Schultz
(Employee elected)
Genmab A/S
Carl Jacobsens Vej 30
2500 Valby, Denmark
Tel: +45 7020 2728
www.genmab.com
Company Announcement no. 48
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CVR no. 2102 3884