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   "value": "1, Accounting policies Oxford Biomedica plc (Oxford Biomedica or the Company) is a public company limited by shares, incorporated and domiciled in England,  and listed on the London Stock Exchange. The consolidated \ufb01nancial statements for the year ended 31 December 2022 comprise the  results of the Company and its subsidiary undertakings (together referred to as the Group). The Company\u2019s principal subsidiary is Oxford Biomedica (UK) Limited. The Group is a cell and gene therapy research, development and bioprocessing business providing services to third parties as well as  performing internal research and development for its own purposes. The Group currently has no marketed pharmaceutical products. ",
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   "value": "1, Accounting policies<span class=\"_ _2b2\"> </span>Oxford Biomedica plc (Oxford Biomedica or the Company) is a public company limited by shares, incorporated and domiciled in England,<span class=\"_ _2b2\"> </span> <span class=\"_ _2b2\">and listed on the London Stock Exchange. The consolidated \ufb01nancial statements for the year ended 31 December 2022 comprise the<span class=\"_ _2b2\"> </span></span> results of the Company and its subsidiary undertakings (together referred to as the Gr<span class=\"_ _25\"></span>oup).<span class=\"_ _2b2\"> </span>The Company\u2019s principal subsidiary is Oxford Biomedica (UK) Limited.<span class=\"_ _2b2\"> </span>The Group is a cell and gene therapy research, development and bioprocessing business pr<span class=\"_ _25\"></span>oviding services to third parties as well as  <span class=\"_ _32\"></span>performing internal research and development for its own purposes. The Group curr<span class=\"_ _25\"></span>ently has no marketed pharmaceutical products.<span class=\"_ _2b2\"> </span>Basis of preparation<span class=\"_ _2b2\"> </span>The principal accounting policies adopted in the preparation of these \ufb01nancial statements are set out below<span class=\"_ _25\"></span>. These policies have been<span class=\"_ _2b2\"> </span> consistently applied to all the \ufb01nancial years presented, unless otherwise stated.<span class=\"_ _2b2\"> </span>The Group and parent Company \ufb01nancial statements were prepar<span class=\"_ _25\"></span>ed in accordance UK<span class=\"_ _25\"></span>-adopted interna<span class=\"_ _25\"></span>tional accounting standards. <span class=\"ls1\"> </span>As more fully explained in the Directors\u2019 Report on pages 115 to 121 and below, the going concern basis has been adopted in pr<span class=\"_ _25\"></span>eparing<span class=\"ls1\"> </span>the \ufb01nancial statements.<span class=\"_ _2b2\"> </span>A summary of the more important Group accounting policies is set out below<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The preparation of the \ufb01nancial statements in conformity with IFRS requir</span><span class=\"_ _25\"></span>es the use of certain critical accounting estimates. It also requiresmanagement to exercise its judgement in the process of applying the Group\u2019s accounting policies. The ar<span class=\"_ _25\"></span>eas involving a higher degree<span class=\"ls1\"> </span>of judgement or complexity, or wher<span class=\"_ _25\"></span>e assumptions and estimates are signi\ufb01cant to the \ufb01nancial statements, are disclosed in note 2.<span class=\"_ _2b2\"> </span>Measurement convention<span class=\"_ _2b2\"> </span>The \ufb01nancial statements are prepared on the historical cost basis except tha<span class=\"_ _25\"></span>t the following assets and liabilities are stated at their fair value:  <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Assets held at fair value through pro\ufb01t &amp; loss<span class=\"_ _2b2\"> </span></span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Put option liability<span class=\"_ _2b2\"> </span></span>Non-current assets and disposal groups held for sale are stated at the lower o<span class=\"_ _25\"></span>f previous carrying amount and fair value less costs to sell.<span class=\"_ _2b2\"> </span>Going concern<span class=\"_ _2b2\"> </span>The \ufb01nancial position of the Group, its cash \ufb02ows and liquidity position are described in the strategic report and notes to these \ufb01nancial<span class=\"_ _2b2\"> </span> statements.<span class=\"_ _2b2\"> </span>The Group made a loss for the year ended 31 December 2022 of \u00a345.2 million and consumed net cash \ufb02ows fr<span class=\"_ _25\"></span>om operating activities<span class=\"ls1\"> </span>for the year of \u00a312.<span class=\"_ _25\"></span>6 million. The Group also:<span class=\"_ _2b2\"> </span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">raised \u00a377<span class=\"_ _3\"></span>.0 million (net of \u00a33 million of shar<span class=\"_ _25\"></span>e issue cost) in cash from an equity fundraise in January and March 2022;<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">entered into a one year US$85 million (\u00a363 million) loan facility with Oaktree as part of the acquisition of Oxford Biomedica Solutions<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span>in March 2022 which was then converted into a four<span class=\"_ _25\"></span>-year term loan facility together with repayment of US$35 million of the initial<span class=\"_ _2b2\"> </span> principal amount in October 2022;<span class=\"_ _2b2\"> </span>  <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">during November 2022, sold its Windrush Court facility in a sale and leaseback transaction for \u00a360 million to Kadans, whilst also<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span>agreeing an occupational lease of the property for 15 years; and<span class=\"_ _2b2\"> </span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">ended the year with cash and cash equivalents of \u00a3141.3 million.<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span>In considering the basis of preparation of the Annual report and accounts, the Directors ha<span class=\"_ _25\"></span>ve prepared cash \ufb02ow forecasts for a period<span class=\"_ _2b2\"> </span> of at least 12 months from the date of approval of these \ufb01nancial sta<span class=\"_ _25\"></span>tements, based in the \ufb01rst instance on the Group\u2019s 2023 annual<span class=\"_ _2b2\"> </span> budget and forecasts for 202<span class=\"_ _25\"></span>4. The Dir<span class=\"_ _25\"></span>ectors have undertaken a rigorous assessment of this base case for<span class=\"_ _25\"></span>ecast and have also assessed<span class=\"_ _2b2\"> </span> the potential impact from the principal risks and uncertainties outlined in the strategic report of the Group\u2019s Annual r<span class=\"_ _25\"></span>eport and accounts,<span class=\"_ _2b2\"> </span> taking into consideration the magnitude and likelihood of these risks and uncertainties occurring to prepare a downside scenario with<span class=\"_ _2b2\"> </span> associated mitigated actions.<span class=\"_ _2b2\"> </span> The cash \ufb02ow forecast prepared for the sever<span class=\"_ _25\"></span>e but plausible downside scenario with mitigating actions assumes the following:<span class=\"_ _2b2\"> </span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\"><span class=\"_ _2b2\">Commercial challenges leading to a substantial manufacturing and development revenue downside affecting both the LentiV</span><span class=\"_ _25\"></span>ector<span class=\"_ _2b2\"> </span></span>\u00ae<span class=\"_ _2b2\"> </span>platform and AA<span class=\"_ _25\"></span>V businesses;<span class=\"_ _2b2\"> </span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Signi\ufb01cant decreases in forecasted existing client milestone and royalty revenues;<span class=\"_ _2b2\"> </span></span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The product development spin out strategy taking longer<span class=\"_ _25\"></span>, or ultimately being unsuccessful; and<span class=\"_ _2b2\"> </span></span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The potential impacts of the current ongoing war in Ukraine on the Group and its clients including expected revenues from existing<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span>clients under long term contracts.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Under both the base case and mitigated downside scenario, the Group and parent company has sufficient cash resources to continue</span><span class=\"ls1\"> </span>in operation for a period of at least 12 months from the date of appr<span class=\"_ _25\"></span>oval of these \ufb01nancial statements.<span class=\"_ _2b2\"> </span>In the event of the downside scenarios crystallising, the Group would continue to meet its existing loan covenants until June 202<span class=\"_ _25\"></span>4 without taking any mitigating actions, but the Board has mitigating actions in place that are entirely within its contr<span class=\"_ _25\"></span>ol that would enable the Group to reduce its spend within a reasonably short time-frame to increase its cash covenant headr<span class=\"_ _25\"></span>oom as required by the loan facility with Oaktree Capital Management. The Board has con\ufb01dence in the Group\u2019s ability to continue as a going concern for the following reasons: <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group has cash balances of \u00a3141.3 million at the end o<span class=\"_ _25\"></span>f December 2022 and \u00a3139<span class=\"_ _25\"></span>.1 million at the end of March 2023;</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Approximately two thirds of 2023 for<span class=\"_ _25\"></span>ecasted revenues are covered by binding purchase orders which give certainty to r<span class=\"_ _25\"></span>evenues over </span>the next 12 months; <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group\u2019s history of being able to access capital markets including raising \u00a377 million of equity during 2022;</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group\u2019s history of being able to obtain loan \ufb01nancing when required for purposes of both capital expenditur<span class=\"_ _25\"></span>e and operational </span>purposes, as recently evidenced by the US$85 million one-year facility and US$50 million replacement four<span class=\"_ _25\"></span>-year facility obtained with Oaktree; <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group\u2019s ability to continue to be successful in winning new clients and building its brand as demonstrated by successfully entering </span>into new and expanding existing client agreements with AstraZeneca, Juno Therapeutics (a wholly owned subsidiary of Bristol Myers Squibb Company), Homology Medicines and multiple other new partners over the last twelve months.<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span><span class=\"_ _2b2\">aking account of the matters described above, the Directors are con\ufb01dent that the Group and parent company will have sufficient </span>funds to continue to meet their liabilities as they fall due for at least 12 months from the date of approval of the \ufb01nancial sta<span class=\"_ _25\"></span>tements and therefore have prepar<span class=\"_ _25\"></span>ed the \ufb01nancial statements on a going concern basis.<span class=\"_ _2b2\"> </span>Accounting developments<span class=\"_ _2b2\"> </span>The Group has adopted the following IFRSs in these \ufb01nancial statements: <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\"><span class=\"_ _2b2\">Annual Improvements to IFRS Standards 2018\u20132020</span></span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Property<span class=\"_ _25\"></span>, Plant and Equipment: Proceed before intended use \u2013 amendments to IAS16<span class=\"_ _2b2\"> </span></span>At the date of authorisation of these Group \ufb01nancial statements, several new<span class=\"_ _25\"></span><span class=\"_ _2b2\">, but not yet effective, Standards and amendments to existing </span>Standards, and Interpretations have been published by the IASB<span class=\"_ _25\"></span>. None of these Standards or amendments to existing Standards has been adopted early by the Group.The Directors anticipate that all relevant pronouncements will be adopted for the \ufb01rst period beginning on or a<span class=\"_ _25\"></span><span class=\"_ _2b2\">fter the effective date of </span>the pronouncement. New Standards, amendments and Interpretations not adopted in the current year ha<span class=\"_ _25\"></span>ve not been disclosed as they are not expected to have a material impact on the Group \ufb01nancial statements.<span class=\"_ _2b2\"> </span>Basis of consolidation<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The consolidated \ufb01nancial statements comprise the Company and its subsidiary undertakings for the year to 31 December each year</span><span class=\"_ _25\"></span>. Subsidiaries are entities that are directly or indirectly contr<span class=\"_ _25\"></span>olled by the Group. Subsidiaries are consolidated from the date at which contr<span class=\"_ _25\"></span>ol is transferred to the Group. Control exists where the Gr<span class=\"_ _25\"></span>oup has the power to govern the \ufb01nancial and operating policies of the entity <span class=\"ls1\"> </span>so as to obtain bene\ufb01ts from its activities. The Group does not currently have any associates.<span class=\"_ _2b2\"> </span>All intragroup transactions and balances are eliminated on consolidation.<span class=\"_ _2b2\"> </span>Foreign currencies<span class=\"_ _2b2\"> </span>Foreign currency transactions The Group\u2019s presentational currency is sterling. T<span class=\"_ _28\"></span>ransactions in foreign currencies are translated into sterling at the rate of exchange<span class=\"ls1\"> </span>ruling at the transaction date. Monetary assets and liabilities denominated in foreign currencies ar<span class=\"_ _25\"></span>e translated into the functional currency at the exchange rate at the reporting date. Non-monetary items that ar<span class=\"_ _25\"></span>e measured at fair value in a foreign currency ar<span class=\"_ _25\"></span>e translated<span class=\"ls1\"> </span>into functional currency at the exchange rate when the fair value was determined. Non-monetary items that are measur<span class=\"_ _25\"></span>ed at historical cost in a foreign currency are translated at the ex<span class=\"_ _25\"></span><span class=\"_ _2b2\">change rate at the date of the transaction. Foreign currency differ</span><span class=\"_ _25\"></span>ences are generally recognised in pro\ufb01t or loss and presented within operational costs.<span class=\"_ _2b2\"> </span>Foreign operations<span class=\"_ _2b2\"> </span>The assets and liabilities of foreign operations, including goodwill and fair value adjustments arising on acquisition, are translated into sterling at the exchanges rates at reporting date. The income and expenses of f<span class=\"_ _25\"></span>oreign operations are translated into sterling at the average exchange rate for the month based on the date of the transaction.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Foreign currency differences are r</span><span class=\"_ _25\"></span>ecognised in OCI and accumulated in the translation reserve, except to the extent that the translation <span class=\"_ _2b2\">difference is allocated to NCI.<span class=\"_ _2b2\"> </span></span>The assets and liabilities of foreign operations are translated to the Gr<span class=\"_ _25\"></span>oup\u2019s presentational currency<span class=\"_ _25\"></span><span class=\"_ _2b2\">, at foreign exchange rates in eff</span><span class=\"_ _25\"></span>ect at the statement of \ufb01nancial position date. The revenue and expenses of for<span class=\"_ _25\"></span>eign operations are translated at an average rate for the year where this rate approximates to the for<span class=\"_ _25\"></span><span class=\"_ _2b2\">eign exchange rates in effect at the dates of the translations. Ex</span><span class=\"_ _25\"></span><span class=\"_ _2b2\">change differences arising from the </span>translation of foreign operations are r<span class=\"_ _25\"></span>eported as an item of other comprehensive income and accumulated in an exchange reserve and subsequently reclassi\ufb01ed to the Consolidated Income Statement on disposal of the net investment.<span class=\"_ _2b2\"> </span>Revenue<span class=\"_ _2b2\"> </span>Revenue comprises income derived from bioprocessing of clinical product for clients, fees char<span class=\"_ _25\"></span>ged for providing development services<span class=\"ls1\"> </span>to clients, product and technology licence transactions, royalties, options, and funded research and development pr<span class=\"_ _25\"></span>ogrammes.<span class=\"_ _2b2\"> </span>Platform<span class=\"_ _2b2\"> </span>The Group bioprocesses batches on behalf of clients who use this manufactured clinical pr<span class=\"_ _25\"></span>oduct for clinical and commercial purposes. The bioprocessing of a batch creates an asset with no alternative <span class=\"_ _25\"></span>use and the Group has an enforceable right to payment for performance completed to date, thereby meeting IFRS 15.35<span class=\"_ _25\"></span>. Bioprocessing of clinical/commercial product for clients is ther<span class=\"_ _25\"></span>efore recognised on a percentage of completion basis over time as the processes are carried out using the Input Method under IFRS. Pr<span class=\"_ _25\"></span>ogress is determined based on the achievement of veri\ufb01able stages of the process with incremental adjustments made based on the percentage of completion of the next unachieved veri\ufb01able stage. The gross amount due from clients, on all partnerships with regards to biopr<span class=\"_ _25\"></span>ocessing batches in progress for which costs incurred plus recognised pr<span class=\"_ _25\"></span>o\ufb01ts exceed progress billings, is presented separa<span class=\"_ _25\"></span>tely as a contract asset within the note to T<span class=\"_ _27\"></span>rade and Other receivables as presented in the statement of \ufb01nancial position.<span class=\"_ _2b2\"> </span>Consideration received in excess of the stage of completion will be deferr<span class=\"_ _25\"></span>ed until such time as it is appropriate to recognise the revenue. The Group has determined that its contracts with clients do not contain a signi\ufb01cant \ufb01nancing component.<span class=\"_ _2b2\"> </span>Revenues for providing process development activities to clients are recognised during the period in which the service is r<span class=\"_ _25\"></span>endered on<span class=\"ls1\"> </span>a percentage of completion basis over time as the processes are carried out. The process development activities ar<span class=\"_ _25\"></span>e recognized over time as the activities create an asset that has no alternative use to the Group and the Group has an en<span class=\"_ _25\"></span>forceable right to payment for the work packages within the process development activity completed to date. <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Oxford Biomedica (UK) Ltd makes use of the output method under IFRS with revenue being r<span class=\"_ _25\"></span>ecognised based on the achievement<span class=\"ls1\"> </span></span>of veri\ufb01able stages of the process.  <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Oxford Biomedica Solutions makes use of the input method under IFRS with revenue being r<span class=\"_ _25\"></span>ecognised based on the labour and other </span><span class=\"_ _2b2\">resources expended to provide the services as a percentage of the total expected eff</span><span class=\"_ _25\"></span>ort to complete the services. T<span class=\"_ _27\"></span>echnology licences that have been established by the Group have all been determined as \u201cright to use\u201d licences, rather than \u201cright to access\u201d licences. As such, the revenue from these licences is recognised at the point in time at which the licence transfers to the client.<span class=\"_ _2b2\"> </span>The granting of the technology licences to the Group\u2019s background intellectual property and know-how constitutes a \u201cright to use\u201d licence as the Group\u2019s clients are able to conduct development work on the licence independent of the Group. The Group is incentivised separately for its performance obligations in relation to development work and milestone payments. The criteria for r<span class=\"_ _25\"></span>ecognising these technology licences as \u201cright to access\u201d licences has therefore not been met.<span class=\"_ _2b2\"> </span>Milestones relating to bioprocessing or process development activities have been identi\ufb01ed as separate perf<span class=\"_ _25\"></span>ormance obligations as<span class=\"ls1\"> </span>they involve the transfer of a distinct good or service, determined with reference to conditions stipulated in the r<span class=\"_ _25\"></span>elevant agreements<span class=\"ls1\"> </span>or contracts. Each milestone is determined as either binary or non-binary.<span class=\"_ _2b2\"> </span>Milestones that are considered to be binary relate to the achievement of speci\ufb01c events ra<span class=\"_ _25\"></span>ther than the provision of, for example, support. Milestones related to the achievement of speci\ufb01c deliverables are considered to be binary milestones and will be r<span class=\"_ _25\"></span>ecognised in full once it is deemed highly probable that the obligation will be met.<span class=\"_ _2b2\"> </span>Milestones related to the provision of support services are consider<span class=\"_ _25\"></span>ed to be non-binary Milestones and are recognised on a percentage of completion basis, but taking into account the likelihood of achievement of the deliverable. Amounts receivable on delivery of a milestone performance obligation represents variable consideration and have been allocated to the r<span class=\"_ _25\"></span>elevant performance obligation.<span class=\"_ _2b2\"> </span>Options to technology licences are considered to form part of the technology licence performance obligation and as such ar<span class=\"_ _25\"></span>e recognised when the client exercises the option to obtain that licence. Options to technology licences are not considered to be ma<span class=\"_ _25\"></span>terial rights.Product<span class=\"_ _2b2\"> </span>Product licences that have been established by the Group have all been determined as \u201cright to use\u201d licences, rather than \u201cright to access\u201d licences. As such, the revenue from these licences is recognised at the point in time at which the licence transfers to the client.<span class=\"_ _2b2\"> </span>The granting of the product licences to the Group\u2019s background intellectual pr<span class=\"_ _25\"></span>operty and know-how constitutes a \u201cright to use\u201d licence as the Group\u2019s clients are able to conduct development work on the licence independent of the Group. The Group is incentivised separately for its performance obligations in relation to development work and milestone payments. The criteria for r<span class=\"_ _25\"></span>ecognising these technology licences as \u201cright to access\u201d licences has therefore not been met.<span class=\"_ _2b2\"> </span>Amounts receivable in respect of milestone payments are considered to be separa<span class=\"_ _25\"></span>te performance obligations which are binary and will be recognised in full once it is deemed highly probable that the speci\ufb01c performance obligations stipulated in the licence agr<span class=\"_ _25\"></span>eement have been met. Payments linked to \u201csuccess\u201d such as regulatory \ufb01ling or approval, or achievement of speci\ufb01ed sales volumes, ar<span class=\"_ _25\"></span>e recognised<span class=\"ls1\"> </span>in full when the relevant event has occurred.<span class=\"_ _2b2\"> </span>Non-binary milestones are recognised on a percentage of completion basis in the period in which rela<span class=\"_ _25\"></span>ted costs are incurred, or over<span class=\"ls1\"> </span>the estimated period to completion of the relevant phase of development or associated clinical trials. Amounts receivable on delivery<span class=\"ls1\"> </span>of a milestone performance obligation represents variable consideration and have been alloca<span class=\"_ _25\"></span>ted to the relevant performance obligation.<span class=\"_ _2b2\"> </span>Royalty revenue is recognised as the underlying commercial sales of the underlying manufactured pr<span class=\"_ _25\"></span>oduct occur to third parties of our contracted clients.<span class=\"_ _2b2\"> </span>Cost of sales<span class=\"_ _2b2\"> </span>Cost of sales comprises the cost of bioprocessing clinical product for clients, the cost of client development pr<span class=\"_ _25\"></span>oject activities, and royalties arising on clients\u2019 licences.<span class=\"_ _2b2\"> </span>The cost of client development project activities includes the labour costs, overheads and other directly attributable material and third party costs. Costs are recognised as incurred.<span class=\"_ _2b2\"> </span>The cost of bioprocessing clinical product for clients includes the raw materials, labour costs, overheads and other directly a<span class=\"_ _25\"></span>ttributable third party costs. Costs are recognised as incurred.<span class=\"_ _2b2\"> </span>The Group\u2019s products and technologies include technology elements that are licensed from thir<span class=\"_ _25\"></span>d parties. Royalties arising from such clients\u2019 licences are treated as cost of sales. Where r<span class=\"_ _25\"></span>oyalties due have not been paid they are included in accruals. Where revenue is spread over a number of accounting periods, the royalty attributable to the deferred r<span class=\"_ _25\"></span>evenue is included in prepayments.<span class=\"_ _2b2\"> </span>Research, development and bioprocessing<span class=\"_ _2b2\"> </span>Research, development and bioprocessing expenditure is charged to the statement of compr<span class=\"_ _25\"></span>ehensive income in the period in which<span class=\"ls1\"> </span>it is incurred.<span class=\"_ _2b2\"> </span>Employee bene\ufb01t costs<span class=\"_ _2b2\"> </span>Employee bene\ufb01t costs, notably holiday pay and contributions to the Group\u2019s de\ufb01ned contribution pension plan, are charged to the statement of comprehensive income on an accruals basis. The assets of the pension scheme are held separately fr<span class=\"_ _25\"></span>om those of the Group <span class=\"_ _2b2\">in independently administered funds. The Group does not offer any other post-retir</span><span class=\"_ _25\"></span>ement bene\ufb01ts.<span class=\"_ _2b2\"> </span>Share based payments<span class=\"_ _2b2\"> </span>The Group\u2019s employee share option schemes, long term incentive plans, a Sharesave scheme and deferr<span class=\"_ _25\"></span>ed bonus plans allow Group employees to acquire shares of the Company subject to certain criteria. The fair value of options granted is recognised as an expense of employment in the statement of comprehensive income with a corresponding increase in equity<span class=\"_ _25\"></span>. The fair value is measured at the date<span class=\"ls1\"> </span>of grant and spread over the period during which the employees become unconditionally entitled to the options where the options are not nil cost options. Nil cost options are valued at the market price on the date of grant of the options. The fair value of options granted under the share option schemes and share save scheme is measured using the Black-<span class=\"_ _27\"></span>Scholes model. The fair value of options granted<span class=\"_ _2\"></span> under the L<span class=\"_ _3\"></span>TIP schemes, which includes market condition performance criteria, is measured using a Monte Carlo model taking into account the performance conditions under which the options were granted. The fair value of options granted under the deferred bonus plan is based on the market value of the underlying shares at the date of grant of these options.<span class=\"_ _2b2\"> </span>At each \ufb01nancial year end, the Group revises its estimate of the number of options that ar<span class=\"_ _25\"></span>e expected to become exercisable based on forfeiture such that at the end of the vesting period the cumulative charge r<span class=\"_ _25\"></span>e\ufb02ects the actual options that have vested, with no charge<span class=\"ls1\"> </span>for those options which were forfeit prior to vesting. When share options ar<span class=\"_ _25\"></span>e exercised the proceeds received are cr<span class=\"_ _25\"></span>edited to equity.<span class=\"_ _2b2\"> </span>Options over the Company\u2019s shares have been awarded to employees of Oxford Biomedica (UK) Ltd. In accor<span class=\"_ _25\"></span><span class=\"_ _2b2\">dance with IFRS 2 \u2019Share-<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">based Payments\u2019, the expense in respect of these awards is recognised in the subsidiaries\u2019 \ufb01nancial statements. In accordance with IFRS 2 </span>the Company has treated the awards as a capital contribution to the subsidiaries, resulting in an increase in the cost of investment and a corresponding credit to reserves.<span class=\"_ _2b2\"> </span>Employee Bene\ufb01t T<span class=\"_ _27\"></span>rust<span class=\"_ _2b2\"> </span>The Oxford Biomedica Employee Bene\ufb01t T<span class=\"_ _27\"></span>rust (EBT) has been set up to hold market-purchased shares to settle the 2013 Deferred Bonus Share Awards made to Executive Directors and employees. Within the Company \ufb01nancial sta<span class=\"_ _25\"></span>tements, the investment in the Oxford Biomedica Employee T<span class=\"_ _27\"></span>rust forms part of the Investments and loans in subsidiary, taking the form o<span class=\"_ _25\"></span>f a loan to subsidiaries. The EBT is consolidated within the Group \ufb01nancial statements.<span class=\"_ _2b2\"> </span>Leases<span class=\"_ _2b2\"> </span>As a lessee<span class=\"_ _2b2\"> </span>At commencement or on modi\ufb01cation of a contract that contains a lease component, the Group allocates the consideration in the contract to each lease component on the basis of its relative stand-alone prices. However<span class=\"_ _3\"></span>, for the leases of property, the Group has elected not to separate non-lease components, and to account for the lease and non-lease components as a single lease component.<span class=\"_ _2b2\"> </span>The Group recognises a right-of-use asset and a lease liability at the lease commencement date. The right-of-use asset is initially measured at cost, which comprises the initial amount of the lease liability adjusted for any lease payments made at or before the commencement date, plus any initial direct costs incurred, and an estimate of costs to dismantle and remove the underlying asset, <span class=\"ls1\"> </span>or to restore the underlying asset or site on which it is located, less any lease incentives received.<span class=\"_ _2b2\"> </span>The right-of-use asset is subsequently depreciated using the straight-line method, from the commencement date to the end of the lease term, unless the lease transfers ownership of the underlying asset to the Group by the end of the lease term, or the cost of the right-of-<span class=\"_ _2b2\"> </span>use asset re\ufb02ects that the Group will exercise a pur<span class=\"_ _25\"></span>chase option. In that case, the right-of-use asset will be depreciated over the useful life of the underlying asset, which is determined on the same basis as those of property and equipment. In addition, the right-of-use asset is periodically reduced by impairment losses, if any<span class=\"_ _25\"></span>, and adjusted for certain re-measurements of the lease liability<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsfb\">The lease liability is initially measured at the present value of the lease payments that are not paid a<span class=\"_ _25\"></span>t the commencement date, discounted<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsfc\">using the interest rate implicit in the lease or<span class=\"_ _25\"></span>, if that rate cannot be readily determined, the Group\u2019s incr<span class=\"_ _25\"></span>emental borrowing rate. Generally<span class=\"_ _25\"></span>,<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsfd\">the Group uses its incremental borrowing rate as the discount rate.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsfe\">The Group determines its incremental borrowing rate by obtaining relevant inter<span class=\"_ _25\"></span>est rates from external \ufb01nancing sources and makes<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsff\">certain adjustments to re\ufb02ect the terms of the lease and the type of the asset leased.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs100\">Lease payments included in the measurement of the lease liability comprise \ufb01xed payments.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs101\"><span class=\"_ _2b2\">The lease liability is measured at amortised cost using the effective interest method. It is re-measur</span><span class=\"_ _25\"></span>ed if:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs102\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">there is a change in the Group\u2019s estimate of the amount expected to be payable under a residual futur<span class=\"_ _25\"></span>e lease payments;<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs103\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the Group changes its assessment of whether it will exercise a purchase, extension or termina<span class=\"_ _25\"></span>tion options; or<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs104\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">there is a revised in-substance \ufb01xed lease payment.<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs105\">If a lease liability is re-measured, a corresponding adjustment is made to the carrying amount of the right-of-use asset, or is r<span class=\"_ _25\"></span>ecorded in<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs106\">the Pro\ufb01t or Loss if the carrying amount of the right-of-use asset has been reduced to zer<span class=\"_ _25\"></span>o.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs107\">The Group presents right-of-use assets in \u2019property<span class=\"_ _25\"></span>, plant and equipment\u2019 and lease liabilities as a category on the face of the Statement<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs108\">of Financial Position.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs109\">Short term or low-value leases<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs10a\">The Group has elected not to recognise right-of-use assets and lease liabilities of short term and low-value leases. The Group r<span class=\"_ _25\"></span>ecognises<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs10b\">lease payments associated with these leases as an expense on a straight-line basis over the lease term.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs10c\">Sales &amp; Leaseback<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs10d\">A sale and leaseback is where the Group sells an asset and immediately reacquires the use o<span class=\"_ _25\"></span>f the asset by entering into a lease with the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs10e\">buyer<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs10f\">For sale and operating leasebacks, generally the assets are sold at fair value, and accordingly the pro\ufb01ts and loss fr<span class=\"_ _25\"></span>om the sale are </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs110\">recognised immediately in the Statement of Pro\ufb01t and loss. The fair value is determined by obtaining a valua<span class=\"_ _25\"></span>tion from an independent </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs111\">property valuation \ufb01rm.</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs112\">A sale occurs when control of the underlying asset passes to the buyer<span class=\"_ _25\"></span>. A lease liability is recognised, the associated property<span class=\"_ _3\"></span>, plant<span class=\"_ _2\"></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs113\">and equipment asset is derecognised, and a right of use asset is recognised at the proportion of the carrying value r<span class=\"_ _25\"></span>elating to the right<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs114\">retained. Any gain or loss arising relates to the rights transferred to the buyer<span class=\"_ _3\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse wsd gs115\">Grants<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs116\">Income from government and other grants is recognised over the period necessary to match them with the related costs which they<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs117\">are intended to compensate. Grant income is included as other operating income within the statement of comprehensive income, and<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs118\">the related costs are included within research, development and biopr<span class=\"_ _25\"></span>ocessing costs, and administrative expenses. Where grant income<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs119\">received exceeds grant income recognised, it is included within deferred income on the S<span class=\"_ _25\"></span>tatement of \ufb01nancial position, whereas grant<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs11a\">income recognised exceeds grant income received, it is included within accrued income on the Statement of \ufb01nancial position.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs11b\">Finance income and costs<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs11c\">Finance income and costs comprise interest income and interest payable during the year<span class=\"_ _25\"></span><span class=\"_ _2b2\">, calculated using the effective interest rate<span class=\"_ _2b2\"> </span></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs11d\">method. It also includes the revaluation of external loans denominated in a foreign curr<span class=\"_ _25\"></span>ency.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs11e\"><span class=\"_ _2b2\">Financing expenses include interest payable and \ufb01nance charges on lease liabilities recognised in pro\ufb01t or loss using the effective inter</span><span class=\"_ _25\"></span>est<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs11f\">method and unwinding of the discount on provisions.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs120\"><span class=\"_ _2b2\">Interest income and interest payable is recognised in pro\ufb01t or loss as it accrues, using the eff</span><span class=\"_ _25\"></span>ective interest method.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse wsd gs121\">T<span class=\"_ _3\"></span>axation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs122\">In 2022 and before, the Group was entitled to claim tax credits in the United Kingdom for certain r<span class=\"_ _25\"></span>esearch and development expenditure.<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs123\">The Group receives a Research and Development Expenditure Cr<span class=\"_ _25\"></span>edit (\u2019RDEC\u2019) which is accounted for as a reduction in research and<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs124\">development costs in the statement of comprehensive income, and within trade and other receivables in the Statement of \ufb01nancial<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs125\">position. The credit is paid in arrears once tax returns have been \ufb01led and agreed.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs126\">Current tax, including UK corporation tax and foreign tax, is provided at amounts expected to be paid (or r<span class=\"_ _25\"></span>ecovered) using the tax rates<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs127\">and laws that have been enacted, or substantially enacted, by the Statement of \ufb01nancial position date.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs128\"><span class=\"_ _2b2\">Deferred tax is calculated in respect of all temporary differ</span><span class=\"_ _25\"></span>ences identi\ufb01ed at the Statement of \ufb01nancial position date except for: the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs129\"><span class=\"_ _2b2\">initial recognition of goodwill; the initial recognition of assets or liabilities that affect neither accounting nor taxable pr</span><span class=\"_ _25\"></span>o\ufb01t other than in<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs12a\"><span class=\"_ _2b2\">a business combination, and differences relating to investments in subsidiaries to the extent that they will pr</span><span class=\"_ _25\"></span>obably not reverse in the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs12b\">foreseeable future.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs12c\">T<span class=\"_ _27\"></span><span class=\"_ _2b2\">emporary differences are differences between the carrying amount of the Group\u2019s assets and liabilities and their tax base. Deferred tax<span class=\"_ _2b2\"> </span></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs12d\"><span class=\"_ _2b2\">liabilities may be offset against deferred tax assets within the same taxable entity or qualifying local tax group. Any remaining deferr</span><span class=\"_ _25\"></span>ed<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs12e\">tax asset is recognised only when, on the basis of all available evidence, it can be regarded as probable tha<span class=\"_ _25\"></span>t there will be suitable taxable<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs12f\"><span class=\"_ _2b2\">pro\ufb01ts within the same jurisdiction in the foreseeable future against which the deductible temporary differ</span><span class=\"_ _25\"></span>ence can be utilised.<span class=\"_ _2b2\"> </span> </div>Deferred tax is measured at the average tax rates that ar<span class=\"_ _25\"></span>e expected to apply in the periods in which the asset is realised or liability settled, based on tax rates and laws that have been enacted or substantially enacted by the Statement of \ufb01nancial position date.<span class=\"_ _2b2\"> </span>Measurement of deferred tax liabilities and assets re\ufb02ects the tax consequence expected to fall fr<span class=\"_ _25\"></span>om the manner in which the asset<span class=\"ls1\"> </span>or liability is recovered or settled.<span class=\"_ _2b2\"> </span>Property, plant and equipment<span class=\"_ _2b2\"> </span>Property<span class=\"_ _25\"></span>, plant and equipment are carried at cost, together with any incidental expenses of acquisition, less depreciation. Cost includes the original purchase price of the asset and any costs attributable to bringing the asset to its working condition for its intended use.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Depreciation is calculated to write off the cost of property</span><span class=\"_ _3\"></span>, plant and equipment less their estimated residual values on a straight-line<span class=\"_ _2\"></span> basis over the expected useful economic lives of the assets concerned. Depreciation of an asset begins when it is available for use. The principal annual rates used for this purpose are:<span class=\"_ _2b2\"> </span>Freehold property<span class=\"_ _1d6\"> </span><span class=\"wsa\">10%<span class=\"_ _2b2\"> </span></span>Leasehold improvements<span class=\"_ _148\"> </span><span class=\"wsa\">10%</span><span class=\"ls1\"> </span>(over the remaining lease term if shorter)<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Office equipment and computers</span><span class=\"_ _1d7\"> </span><span class=\"wsa\">20\u201333%<span class=\"_ _2b2\"> </span></span>Bioprocessing and laboratory equipment<span class=\"_ _1d8\"> </span><span class=\"wsa\">20%<span class=\"_ _2b2\"> </span></span>The assets\u2019 residual values and useful lives are reviewed annually<span class=\"_ _25\"></span>. Residual values are set at zero and will be r<span class=\"_ _25\"></span>eassessed should the asset\u2019s selling price exceed its net book value.<span class=\"_ _2b2\"> </span>The bioprocessing plants are reviewed annually for impairment triggers and, where necessary<span class=\"_ _3\"></span>, a full impairment review is performed.<span class=\"_ _2b2\"> </span>Assets under construction are capitalised throughout the course of the construction period with depreciation starting once the asset is available for use.<span class=\"_ _2b2\"> </span>Assets capitalised under a category of \ufb01xed assets may be transferred to another category within \ufb01x<span class=\"_ _25\"></span>ed assets if, upon review, it is identi\ufb01ed that the asset is more appropriately identi\ufb01able with that other category of \ufb01x<span class=\"_ _25\"></span>ed asset.<span class=\"_ _2b2\"> </span>Intangible assets &amp; Goodwill<span class=\"_ _2b2\"> </span>Recognition and measurement<span class=\"_ _2b2\"> </span>Goodwill<span class=\"_ _2b2\"> </span>Goodwill arising on the acquisition of subsidiaries is measured at cost less accumulated impairment losses.<span class=\"_ _2b2\"> </span>Developed technology<span class=\"_ _2b2\"> </span>Developed technology acquired by the Group (see note 11) has a \ufb01nite useful life. It is measured at cost less accumulated amortisation and any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Patents<span class=\"_ _2b2\"> </span>Patents have \ufb01nite useful lives and are measured at cost less accumulated amortisation and <span class=\"ls1\"> </span>any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Subsequent expenditure<span class=\"_ _2b2\"> </span>Subsequent expenditure is capitalised only when it increases the future economic bene\ufb01ts embodied in the speci\ufb01c asset to which it relates. All other expenditure, including expenditure on internally generated goodwill and brands, is r<span class=\"_ _25\"></span>ecognised in pro\ufb01t or loss as incurred.<span class=\"_ _2b2\"> </span>Cash generating unit (CGU)<span class=\"_ _2b2\"> </span>A cash generating unit is the smallest group of assets that independently generates cash \ufb02ow and whose cash \ufb02ow is largely independent of the cash \ufb02ows generated by other assets.<span class=\"_ _2b2\"> </span>Amortisation<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Amortisation is calculated to write off the cost of intangible assets less their estimated residual values using the straight-line method over </span>their estimated useful lives, and is generally recognised in pro\ufb01t or loss. Goodwill is not amortised. The estimated useful lives for current and comparative periods are as follows:  <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">patents: 3\u201320 years</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">developed technology: 15 years<span class=\"_ _2b2\"> </span></span>Amortisation methods, useful lives and residual values are reviewed at each r<span class=\"_ _25\"></span>eporting date and adjusted if appropriate.<span class=\"_ _2b2\"> </span>Impairment<span class=\"_ _2b2\"> </span>The carrying value of non-\ufb01nancial assets is reviewed annually for impairment, or earlier if an indication of impairment occurs, and  <span class=\"_ _32\"></span>provision made where appropriate. Charges or cr<span class=\"_ _25\"></span>edits for impairment are passed through the statement of comprehensive income.<span class=\"_ _2b2\"> </span><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs163\">For the purposes of assessing impairments, assets are grouped at the lowest levels for which there ar<span class=\"_ _25\"></span>e separately identi\ufb01able cash \ufb02ows or<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs164\">cash-generating units. Impairment losses are recognised for the amount by which each asset\u2019s carrying amount exceeds its r<span class=\"_ _25\"></span>ecoverable<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs165\">amount. The recoverable amount is the higher of an asset\u2019s fair value less costs to sell, and value in use. V<span class=\"_ _25\"></span>alue in use is calculated using<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs166\">estimated discounted future cash \ufb02ows. The key assumptions used in calculating the discounted future cash \ufb02ows ar<span class=\"_ _25\"></span>e management<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs167\">estimates, based where possible on available market informa<span class=\"_ _25\"></span>tion and information for similar products.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs168\">Impairment and amortisation charges are included within research, development and biopr<span class=\"_ _25\"></span>ocessing costs in the statement of<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs169\">comprehensive income.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs16a\">Intellectual property rights comprise third party patent rights or rights to market commercial pr<span class=\"_ _25\"></span>oducts for key therapeutic indications that<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs16b\">have been purchased by the Group.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs16c\">Investments in subsidiaries<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs16d\">Investments are carried at cost less any provision made for impairment. Options over the Company\u2019s shares have been awar<span class=\"_ _25\"></span>ded to<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs16e\">employees of subsidiary companies. In accordance with IFRS2, the Company treats the value of these awards as a capital contribution<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs16f\">to the subsidiaries, resulting in an increase in the cost of investment.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs170\">Investments in subsidiary undertakings, including shares and loans, are carried at cost less any impairment provision. Such investments are<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs171\">subject to review, and any impairment is charged to the statement o<span class=\"_ _25\"></span>f comprehensive income.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs172\">At each year end the Directors review the carrying value of the Company\u2019s investment in subsidiaries. Where ther<span class=\"_ _25\"></span>e is a material and<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs173\">sustained shortfall in the market capitalisation, or a signi\ufb01cant and sustained change in the business resulting in a decrease in mark<span class=\"_ _25\"></span>et<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs174\">capitalisation, the Directors consider this to be a trigger of an impairment review as set out in IAS 36<span class=\"_ _25\"></span>, and the carrying value of the<span class=\"_ _2b2\"> </span> </div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs175\">Company\u2019s investments in subsidiaries is adjusted. The Directors consider that reference to the mark<span class=\"_ _25\"></span>et capitalisation of the Group<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs176\">is an appropriate external measure of the value of the Company\u2019s subsidiaries for this purpose.<span class=\"_ _2b2\"> </span></div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs177\">At year end the Directors will assess the requirement to write back a portion or all of any impairment pr<span class=\"_ _25\"></span>eviously recognised on its<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs178\">investment in subsidiaries. Factors which will be taken into account with regar<span class=\"_ _25\"></span>d to this decision will be the Groups track record of<span class=\"_ _2b2\"> </span> </div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs179\">improved \ufb01nancial results across the last three to four years, as well as the expecta<span class=\"_ _25\"></span>tion of future impairments being required after a write<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs17a\">back was accounted for<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs17b\">Financial assets<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs17c\">Assets at fair value through pro\ufb01t and loss<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs17d\">The gain or loss on Assets at fair value through pro\ufb01t and loss is recognised in the statement o<span class=\"_ _25\"></span>f comprehensive income.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gs17e\">Investments<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs17f\">Other investments held by the Group are classi\ufb01ed as at fair value through pro<span class=\"_ _25\"></span>\ufb01t and loss.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs180\">Bank deposits<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs181\">Bank deposits with original maturities between three months and twelve months are included in current assets and are valued<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs182\">at amortised cost.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs183\">Financial instruments<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gs184\">Classi\ufb01cation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs185\">On initial recognition, a \ufb01nancial asset is classi\ufb01ed as measured at: amortised cost; FVOCI \u2013 debt investment; FVOCI \u2013 equity investment;<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs186\">or FVTPL. Financial assets are not reclassi\ufb01ed subsequent to their initial recognition unless the Company changes its business model for<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs187\"><span class=\"_ _2b2\">managing \ufb01nancial assets in which case all affected \ufb01nancial assets are reclassi\ufb01ed on the \ufb01rst day of the \ufb01rst reporting period f</span><span class=\"_ _25\"></span>ollowing<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs188\">the change in the business model.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs189\">A \ufb01nancial asset is measured at amortised cost if it meets both of the following conditions and is not designated as at FVTPL:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs18a\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">it is held within a business model whose objective is to hold assets to collect contractual cash \ufb02ows; and<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs18b\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">its contractual terms give rise on speci\ufb01ed dates to cash \ufb02ows that are solely payments of principal and interest on the principal<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs18c\">amount outstanding.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs18d\">A debt investment is measured at FVOCI if it meets both of the following conditions and is not designated as at FVTPL:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs18e\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">it is held within a business model whose objective is achieved by both collecting contractual cash \ufb02ows and selling \ufb01nancial assets;<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs18f\">and<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs190\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">its contractual terms give rise on speci\ufb01ed dates to cash \ufb02ows that are solely payments of principal, and interest on the principal<span class=\"_ _2b2\"> </span></span><span class=\"lse\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs191\">amount outstanding.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs192\">On initial recognition of an equity investment that is not held for trading, the Company may irrevocably elect to present subsequent<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs193\">changes in the investment\u2019s fair value in OCI. This election is made on an investment-by-investment basis.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs194\">All \ufb01nancial assets not classi\ufb01ed as measured at amortised cost or FVOCI as described above, are measured at FVTPL. This includes<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs195\">all derivative \ufb01nancial assets. On initial recognition, the Group may irrevocably designate a \ufb01nancial asset that otherwise meets the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs196\">requirements to be measured at amortised cost or at FVOCI<span class=\"_ _25\"></span>, as at FVTPL if doing so eliminates, or signi\ufb01cantly reduces an accounting<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs197\">mismatch that would otherwise arise.<span class=\"_ _2b2\"> </span></div>Derecognition<span class=\"_ _2b2\"> </span>Financial assets<span class=\"_ _2b2\"> </span>The Group derecognises a \ufb01nancial asset when: <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the contractual rights to the cash \ufb02ows from the \ufb01nancial asset expire; or</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">it transfers the rights to receive the contractual cash \ufb02ows in a transaction in which either; or</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">substantially all of the risks and rewards of ownership of the \ufb01nancial asset are transf<span class=\"_ _25\"></span>erred; or</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the Group neither transfers nor retains substantially all of the risks and rewar<span class=\"_ _25\"></span>ds of ownership, and it does not retain control of<span class=\"ls1\"> </span></span>the \ufb01nancial asset.<span class=\"_ _2b2\"> </span>Financial liabilities<span class=\"_ _2b2\"> </span>The Group derecognises a \ufb01nancial liability when its contractual obligations are discharged or cancelled, or expir<span class=\"_ _25\"></span>e. The Group also <span class=\"_ _2b2\">derecognises a \ufb01nancial liability when its terms are modi\ufb01ed and the cash \ufb02ows of the modi\ufb01ed liability are substantially differ</span><span class=\"_ _25\"></span>ent, in which case a new \ufb01nancial liability based on the modi\ufb01ed terms is recognised at fair value.<span class=\"_ _2b2\"> </span>On derecognition of a \ufb01nancial liability<span class=\"_ _25\"></span><span class=\"_ _2b2\">, the difference between the carrying amount extinguished and the consideration paid (including </span>any non-cash assets transferred or liabilities assumed), is recognised in pro\ufb01t or loss.<span class=\"_ _2b2\"> </span>Inventories<span class=\"_ _2b2\"> </span>Inventories are stated at the lower of cost and net realisable value. Cost is determined using the weighted average method. It ex<span class=\"_ _25\"></span>cludes borrowing costs. Net realisable value is the estimated selling price in the ordinary course of business, less applicable variable selling expenses.<span class=\"_ _2b2\"> </span>T<span class=\"_ _3\"></span>rade receivables<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>rade receivables are recognised initially at the transaction price as these assets do not have signi\ufb01cant \ufb01nancing components, and are subsequently measured at amortised cost. The Group recognises loss allowances for r<span class=\"_ _25\"></span>eceivables under the expected credit loss model<span class=\"ls1\"> </span>as established by evidence that the Group will not be able to collect all amounts due according to the original terms of the receivables.<span class=\"_ _2b2\"> </span>Cash and cash equivalents<span class=\"_ _2b2\"> </span>Cash and cash equivalents include cash in hand, bank deposits repayable on demand, and other short term highly liquid investments with original maturities of three months or less.<span class=\"_ _2b2\"> </span>Deposits<span class=\"_ _2b2\"> </span>Deposits consist of amounts held in escrow and is included within other receivables within the Statement of \ufb01nancial position until such time as the restrictions relating to those amounts have been lifted.<span class=\"_ _2b2\"> </span>T<span class=\"_ _3\"></span>rade payables<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span><span class=\"_ _2b2\">rade payables are recognised initially at fair value and subsequently measured at amortised cost using the effective interest method.</span><span class=\"ls1\"> </span>T<span class=\"_ _27\"></span>rade payables are classi\ufb01ed as current liabilities if payment is due within one year or less. If not, they are presented as non-current liabilities.<span class=\"_ _2b2\"> </span>Contract liabilities<span class=\"_ _2b2\"> </span>Contract liabilities primarily relate to the advance consideration received from clients for commer<span class=\"_ _25\"></span>cial development work and bioprocessing batches, as well as options and funded research and development activities.<span class=\"_ _2b2\"> </span>Deferred income<span class=\"_ _2b2\"> </span>Deferred income primarily relates to the advance consideration received f<span class=\"_ _25\"></span>or grants and lease incentives.<span class=\"_ _2b2\"> </span>Provisions<span class=\"_ _2b2\"> </span>Provisions for dilapidation costs and other potential liabilities are recognised when the Gr<span class=\"_ _25\"></span>oup has a present legal or constructive obligation as a result of past events; it is probable that an out\ufb02ow of r<span class=\"_ _25\"></span>esources will be required to settle the obligation; and the amount has been reliably estimated. Provisions are not recognised f<span class=\"_ _25\"></span>or future operating losses.<span class=\"_ _2b2\"> </span>Provisions are measured at the present value o<span class=\"_ _25\"></span>f the expenditure expected to be required to settle the obligation using the 3 year historic in\ufb02ation rate. The increase in the provision due to the passage of time is r<span class=\"_ _25\"></span>ecognised as a \ufb01nance cost.<span class=\"_ _2b2\"> </span>Share capital<span class=\"_ _2b2\"> </span>Ordinary shares are classi\ufb01ed as equity<span class=\"_ _25\"></span>. Costs of share issues are charged to the shar<span class=\"_ _25\"></span>e premium account.<span class=\"_ _2b2\"> </span>Merger reserve<span class=\"_ _2b2\"> </span>A merger reserve is used where more than 90% of the shar<span class=\"_ _25\"></span>es in a subsidiary are acquired and the consideration includes the issue of new shares by the Company<span class=\"_ _25\"></span>, thereby attracting merger relief under s612 and s613 of the Companies Act 2006<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1c9\">Business combinations<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ca\">The Group accounts for business combinations using the acquisition method when the acquired set of activities and assets meets<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1cb\">the de\ufb01nition of a business and control is transferred to the Group. In determining whether a particular set of activities and assets is a<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1cc\">business, the Group assesses whether the set of assets and activities acquired includes, at a minimum, an input and substantive process,<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1cd\">and whether the acquired set has the ability to produce outputs. The Group has an option to apply a \u2019concentration test\u2019 that permits<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ce\">a simpli\ufb01ed assessment of whether an acquired set of activities and assets is not a business. The optional concentration test is met if<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1cf\">substantially all of the fair value of the gross assets acquired is concentrated in a single identi\ufb01able asset or group o<span class=\"_ _25\"></span>f similar identi\ufb01able<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d0\">assets. The consideration transferred in the acquisition is generally measured at fair value, as are the identi\ufb01able net assets acquir<span class=\"_ _25\"></span>ed.<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d1\">Any goodwill that arises is tested annually for impairment. Any gain on a bargain purchase is recognised in pro<span class=\"_ _25\"></span>\ufb01t or loss immediately.<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d2\">T<span class=\"_ _27\"></span>ransaction costs are expensed as incurred, except if related to the issue of debt or equity securities.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d3\">The consideration transferred does not include amounts related to the settlement of pr<span class=\"_ _25\"></span>e-existing relationships. Such amounts are<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d4\">generally recognised in pro\ufb01t or loss.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1d5\">Non-controlling interests (NCI)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d6\">NCI are measured initially at the Group\u2019s proportiona<span class=\"_ _25\"></span>te interest in the recognised amount of the identi\ufb01able assets and liabilities of the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d7\">acquiree. NCI are measured subsequently at their proportiona<span class=\"_ _25\"></span>te share of the subsidiary\u2019s net assets at the reporting date. Changes in the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d8\">Group\u2019s interest in a subsidiary that do not result in a loss of contr<span class=\"_ _25\"></span>ol are accounted for as equity transactions.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1d9\">When a foreign operation is disposed of in its entirety<span class=\"_ _25\"></span>, or partially such that control, signi\ufb01cant control or joint contr<span class=\"_ _25\"></span>ol, is lost, the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1da\">cumulative amount in the translation reserve related to the for<span class=\"_ _25\"></span>eign operation is reclassi\ufb01ed to pro\ufb01t or loss as part of the gain or loss on<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1db\">disposal. If the Group disposes of part of its interest in a subsidiary but retains contr<span class=\"_ _25\"></span>ol, then the relevant proportion of the cumulative<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1dc\">amount is reattributed to NCI. When the Group disposes o<span class=\"_ _25\"></span>f only part of an associate or joint venture while retaining signi\ufb01cant in\ufb02uence<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1dd\">or joint control, the relevant proportion of the cumulative amount is r<span class=\"_ _25\"></span>eclassi\ufb01ed to pro\ufb01t or loss.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1de\">Financial liability: loans<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1df\">On initial recognition, external loans are measured at fair value plus directly a<span class=\"_ _25\"></span>ttributable transaction costs. On subsequent measurement,<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e0\"><span class=\"_ _2b2\">external loans are measured at amortised cost under the effective interest rate method. The eff</span><span class=\"_ _25\"></span>ective interest rate method is a method<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e1\">of calculating the amortised cost of a \ufb01nancial liability and allocating the interest expense over the relevant period. The calculation o<span class=\"_ _25\"></span>f the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e2\"><span class=\"_ _2b2\">effective interest rate takes into account the estimated cash \ufb02ows which consider all the contractual terms of the \ufb01nancial instrument,<span class=\"_ _2b2\"> </span></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e3\">including any embedded derivatives which are not subject to separation.<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1e4\">Financial liability: Put Options<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e5\">Where a put option with non-controlling shareholders (NCI) exists on their equity interests, a liability for the fair value o<span class=\"_ _25\"></span>f the exercise price<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e6\">of the option is recognised.<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e7\">Management have assessed that the NCI still have access to the returns associated with the underlying ownership interests, and have<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e8\">therefore chosen to apply the present access method under which the corresponding entry is r<span class=\"_ _25\"></span>ecognised in Other Equity. As r<span class=\"_ _25\"></span>equired by<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1e9\">IFRS, Oxford Biomedica has chosen to apply an accounting policy<span class=\"_ _25\"></span>, to be applied consistently for all put liabilities: that subsequent to initial<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ea\">recognition, changes in fair value of the put liability will be recognised in equity<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1eb\">The value of the put liability is determined using a Monte Carlo simulation which calculates the expected future exercise value o<span class=\"_ _25\"></span>f the put<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ec\">option, taking into consideration Oxford Biomedica Solutions\u2019 forecasted cash \ufb02ows over the period up until the expected exer<span class=\"_ _25\"></span>cise date<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ed\">along with the expected volatility of those cash \ufb02ows over that same period. The expected future exercise value is then discounted to<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs52\">the present using a discount rate in order to capture the counter party risk of the expected payment. The discount rate may be impacted<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ee\">by economic and market factors as well as changes to the risk free rate of return which impacts debt borr<span class=\"_ _25\"></span>owing rates.<span class=\"_ _2b2\"> </span></div>",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-384": {
   "value": "1, Accounting policies<span class=\"_ _2b2\"> </span>Oxford Biomedica plc (Oxford Biomedica or the Company) is a public company limited by shares, incorporated and domiciled in England,<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">and listed on the London Stock Exchange. The consolidated \ufb01nancial statements for the year ended 31 December 2022 comprise the<span class=\"_ _2b2\"> </span></span>results of the Company and its subsidiary undertakings (together referred to as the Gr<span class=\"_ _25\"></span>oup).<span class=\"_ _2b2\"> </span>The Company\u2019s principal subsidiary is Oxford Biomedica (UK) Limited.<span class=\"_ _2b2\"> </span>The Group is a cell and gene therapy research, development and bioprocessing business pr<span class=\"_ _25\"></span>oviding services to third parties as well as <span class=\"_ _32\"></span>performing internal research and development for its own purposes. The Group curr<span class=\"_ _25\"></span>ently has no marketed pharmaceutical products.<span class=\"_ _2b2\"> </span>Basis of preparation<span class=\"_ _2b2\"> </span>The principal accounting policies adopted in the preparation of these \ufb01nancial statements are set out below<span class=\"_ _25\"></span>. These policies have been<span class=\"_ _2b2\"> </span>consistently applied to all the \ufb01nancial years presented, unless otherwise stated.<span class=\"_ _2b2\"> </span>The Group and parent Company \ufb01nancial statements were prepar<span class=\"_ _25\"></span>ed in accordance UK<span class=\"_ _25\"></span>-adopted interna<span class=\"_ _25\"></span>tional accounting standards. <span class=\"ls1\"> </span>As more fully explained in the Directors\u2019 Report on pages 115 to 121 and below, the going concern basis has been adopted in pr<span class=\"_ _25\"></span>eparing<span class=\"ls1\"> </span>the \ufb01nancial statements.<span class=\"_ _2b2\"> </span>A summary of the more important Group accounting policies is set out below<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The preparation of the \ufb01nancial statements in conformity with IFRS requir</span><span class=\"_ _25\"></span>es the use of certain critical accounting estimates. It also requiresmanagement to exercise its judgement in the process of applying the Group\u2019s accounting policies. The ar<span class=\"_ _25\"></span>eas involving a higher degree<span class=\"ls1\"> </span>of judgement or complexity, or wher<span class=\"_ _25\"></span>e assumptions and estimates are signi\ufb01cant to the \ufb01nancial statements, are disclosed in note 2.<span class=\"_ _2b2\"> </span>Measurement convention<span class=\"_ _2b2\"> </span>The \ufb01nancial statements are prepared on the historical cost basis except tha<span class=\"_ _25\"></span>t the following assets and liabilities are stated at their fair value:\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Assets held at fair value through pro\ufb01t &amp; loss<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Put option liability<span class=\"_ _2b2\"> </span></span>Non-current assets and disposal groups held for sale are stated at the lower o<span class=\"_ _25\"></span>f previous carrying amount and fair value less costs to sell.<span class=\"_ _2b2\"> </span>Going concern<span class=\"_ _2b2\"> </span>The \ufb01nancial position of the Group, its cash \ufb02ows and liquidity position are described in the strategic report and notes to these \ufb01nancial<span class=\"_ _2b2\"> </span>statements.<span class=\"_ _2b2\"> </span>The Group made a loss for the year ended 31 December 2022 of \u00a345.2 million and consumed net cash \ufb02ows fr<span class=\"_ _25\"></span>om operating activities<span class=\"ls1\"> </span>for the year of \u00a312.<span class=\"_ _25\"></span>6 million. The Group also:<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">raised \u00a377<span class=\"_ _3\"></span>.0 million (net of \u00a33 million of shar<span class=\"_ _25\"></span>e issue cost) in cash from an equity fundraise in January and March 2022;<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">entered into a one year US$85 million (\u00a363 million) loan facility with Oaktree as part of the acquisition of Oxford Biomedica Solutions<span class=\"_ _2b2\"> </span></span>in March 2022 which was then converted into a four<span class=\"_ _25\"></span>-year term loan facility together with repayment of US$35 million of the initial<span class=\"_ _2b2\"> </span>principal amount in October 2022;<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">during November 2022, sold its Windrush Court facility in a sale and leaseback transaction for \u00a360 million to Kadans, whilst also<span class=\"_ _2b2\"> </span></span>agreeing an occupational lease of the property for 15 years; and<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">ended the year with cash and cash equivalents of \u00a3141.3 million.<span class=\"_ _2b2\"> </span></span>In considering the basis of preparation of the Annual report and accounts, the Directors ha<span class=\"_ _25\"></span>ve prepared cash \ufb02ow forecasts for a period<span class=\"_ _2b2\"> </span>of at least 12 months from the date of approval of these \ufb01nancial sta<span class=\"_ _25\"></span>tements, based in the \ufb01rst instance on the Group\u2019s 2023 annual<span class=\"_ _2b2\"> </span>budget and forecasts for 202<span class=\"_ _25\"></span>4. The Dir<span class=\"_ _25\"></span>ectors have undertaken a rigorous assessment of this base case for<span class=\"_ _25\"></span>ecast and have also assessed<span class=\"_ _2b2\"> </span>the potential impact from the principal risks and uncertainties outlined in the strategic report of the Group\u2019s Annual r<span class=\"_ _25\"></span>eport and accounts,<span class=\"_ _2b2\"> </span>taking into consideration the magnitude and likelihood of these risks and uncertainties occurring to prepare a downside scenario with<span class=\"_ _2b2\"> </span>associated mitigated actions.<span class=\"_ _2b2\"> </span>The cash \ufb02ow forecast prepared for the sever<span class=\"_ _25\"></span>e but plausible downside scenario with mitigating actions assumes the following:<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\"><span class=\"_ _2b2\">Commercial challenges leading to a substantial manufacturing and development revenue downside affecting both the LentiV</span><span class=\"_ _25\"></span>ector<span class=\"_ _2b2\"> </span></span>\u00ae<span class=\"_ _2b2\"> </span>platform and AA<span class=\"_ _25\"></span>V businesses;<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Signi\ufb01cant decreases in forecasted existing client milestone and royalty revenues;<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The product development spin out strategy taking longer<span class=\"_ _25\"></span>, or ultimately being unsuccessful; and<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The potential impacts of the current ongoing war in Ukraine on the Group and its clients including expected revenues from existing<span class=\"_ _2b2\"> </span></span>clients under long term contracts.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Under both the base case and mitigated downside scenario, the Group and parent company has sufficient cash resources to continue</span><span class=\"ls1\"> </span>in operation for a period of at least 12 months from the date of appr<span class=\"_ _25\"></span>oval of these \ufb01nancial statements.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span>TEMENTS<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs55\">In the event of the downside scenarios crystallising, the Group would continue to meet its existing loan covenants until June 202<span class=\"_ _25\"></span>4 </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs56\">without taking any mitigating actions, but the Board has mitigating actions in place that are entirely within its contr<span class=\"_ _25\"></span>ol that would enable </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs57\">the Group to reduce its spend within a reasonably short time-frame to increase its cash covenant headr<span class=\"_ _25\"></span>oom as required by the loan </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs58\">facility with Oaktree Capital Management. The Board has con\ufb01dence in the Group\u2019s ability to continue as a going concern for the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs59\">following reasons:</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs5a\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group has cash balances of \u00a3141.3 million at the end o<span class=\"_ _25\"></span>f December 2022 and \u00a3139<span class=\"_ _25\"></span>.1 million at the end of March 2023;</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs5b\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Approximately two thirds of 2023 for<span class=\"_ _25\"></span>ecasted revenues are covered by binding purchase orders which give certainty to r<span class=\"_ _25\"></span>evenues over </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5c\">the next 12 months;</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs5d\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group\u2019s history of being able to access capital markets including raising \u00a377 million of equity during 2022;</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs5e\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group\u2019s history of being able to obtain loan \ufb01nancing when required for purposes of both capital expenditur<span class=\"_ _25\"></span>e and operational </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5f\">purposes, as recently evidenced by the US$85 million one-year facility and US$50 million replacement four<span class=\"_ _25\"></span>-year facility obtained with </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs60\">Oaktree;</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs61\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The Group\u2019s ability to continue to be successful in winning new clients and building its brand as demonstrated by successfully entering </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs62\">into new and expanding existing client agreements with AstraZeneca, Juno Therapeutics (a wholly owned subsidiary of Bristol Myers </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs63\">Squibb Company), Homology Medicines and multiple other new partners over the last twelve months.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs64\">T<span class=\"_ _27\"></span><span class=\"_ _2b2\">aking account of the matters described above, the Directors are con\ufb01dent that the Group and parent company will have sufficient </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs65\">funds to continue to meet their liabilities as they fall due for at least 12 months from the date of approval of the \ufb01nancial sta<span class=\"_ _25\"></span>tements and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs66\">therefore have prepar<span class=\"_ _25\"></span>ed the \ufb01nancial statements on a going concern basis.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs67\">Accounting developments<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs68\">The Group has adopted the following IFRSs in these \ufb01nancial statements:</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs69\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\"><span class=\"_ _2b2\">Annual Improvements to IFRS Standards 2018\u20132020</span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs6a\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Property<span class=\"_ _25\"></span>, Plant and Equipment: Proceed before intended use \u2013 amendments to IAS16<span class=\"_ _2b2\"> </span></span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs6b\">At the date of authorisation of these Group \ufb01nancial statements, several new<span class=\"_ _25\"></span><span class=\"_ _2b2\">, but not yet effective, Standards and amendments to existing </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs6c\">Standards, and Interpretations have been published by the IASB<span class=\"_ _25\"></span>. None of these Standards or amendments to existing Standards has been </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs6d\">adopted early by the Group.</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs6e\">The Directors anticipate that all relevant pronouncements will be adopted for the \ufb01rst period beginning on or a<span class=\"_ _25\"></span><span class=\"_ _2b2\">fter the effective date of </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs6f\">the pronouncement. New Standards, amendments and Interpretations not adopted in the current year ha<span class=\"_ _25\"></span>ve not been disclosed as they </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs70\">are not expected to have a material impact on the Group \ufb01nancial statements.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs71\">Basis of consolidation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs72\"><span class=\"_ _2b2\">The consolidated \ufb01nancial statements comprise the Company and its subsidiary undertakings for the year to 31 December each year</span><span class=\"_ _25\"></span>. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs73\">Subsidiaries are entities that are directly or indirectly contr<span class=\"_ _25\"></span>olled by the Group. Subsidiaries are consolidated from the date at which contr<span class=\"_ _25\"></span>ol </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs74\">is transferred to the Group. Control exists where the Gr<span class=\"_ _25\"></span>oup has the power to govern the \ufb01nancial and operating policies of the entity <span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs75\">so as to obtain bene\ufb01ts from its activities. The Group does not currently have any associates.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs76\">All intragroup transactions and balances are eliminated on consolidation.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs77\">Foreign currencies<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs78\">Foreign currency transactions </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs79\">The Group\u2019s presentational currency is sterling. T<span class=\"_ _28\"></span>ransactions in foreign currencies are translated into sterling at the rate of exchange<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs7a\">ruling at the transaction date. Monetary assets and liabilities denominated in foreign currencies ar<span class=\"_ _25\"></span>e translated into the functional currency </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs7b\">at the exchange rate at the reporting date. Non-monetary items that ar<span class=\"_ _25\"></span>e measured at fair value in a foreign currency ar<span class=\"_ _25\"></span>e translated<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs7c\">into functional currency at the exchange rate when the fair value was determined. Non-monetary items that are measur<span class=\"_ _25\"></span>ed at historical </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs7d\">cost in a foreign currency are translated at the ex<span class=\"_ _25\"></span><span class=\"_ _2b2\">change rate at the date of the transaction. Foreign currency differ</span><span class=\"_ _25\"></span>ences are generally </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs7e\">recognised in pro\ufb01t or loss and presented within operational costs.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs7f\">Foreign operations<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs80\">The assets and liabilities of foreign operations, including goodwill and fair value adjustments arising on acquisition, are translated into </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs81\">sterling at the exchanges rates at reporting date. The income and expenses of f<span class=\"_ _25\"></span>oreign operations are translated into sterling at the average </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs82\">exchange rate for the month based on the date of the transaction.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs83\"><span class=\"_ _2b2\">Foreign currency differences are r</span><span class=\"_ _25\"></span>ecognised in OCI and accumulated in the translation reserve, except to the extent that the translation </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs84\"><span class=\"_ _2b2\">difference is allocated to NCI.<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs85\">The assets and liabilities of foreign operations are translated to the Gr<span class=\"_ _25\"></span>oup\u2019s presentational currency<span class=\"_ _25\"></span><span class=\"_ _2b2\">, at foreign exchange rates in eff</span><span class=\"_ _25\"></span>ect </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs86\">at the statement of \ufb01nancial position date. The revenue and expenses of for<span class=\"_ _25\"></span>eign operations are translated at an average rate for the year </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs87\">where this rate approximates to the for<span class=\"_ _25\"></span><span class=\"_ _2b2\">eign exchange rates in effect at the dates of the translations. Ex</span><span class=\"_ _25\"></span><span class=\"_ _2b2\">change differences arising from the </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs88\">translation of foreign operations are r<span class=\"_ _25\"></span>eported as an item of other comprehensive income and accumulated in an exchange reserve and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs89\">subsequently reclassi\ufb01ed to the Consolidated Income Statement on disposal of the net investment.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h6 ff9 fs3 fcb sc0 ls4 ws4 gs8b\">NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c\"><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse wsd gs8d\">Revenue<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8e\">Revenue comprises income derived from bioprocessing of clinical product for clients, fees char<span class=\"_ _25\"></span>ged for providing development services<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8f\">to clients, product and technology licence transactions, royalties, options, and funded research and development pr<span class=\"_ _25\"></span>ogrammes.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gs90\">Platform<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs91\">The Group bioprocesses batches on behalf of clients who use this manufactured clinical pr<span class=\"_ _25\"></span>oduct for clinical and commercial purposes. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws19 gs92\">The bioprocessing of a batch creates an asset with no alternative <span class=\"_ _25\"></span>use and the Group has an enforceable right to payment for performance </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs93\">completed to date, thereby meeting IFRS 15.35<span class=\"_ _25\"></span>. Bioprocessing of clinical/commercial product for clients is ther<span class=\"_ _25\"></span>efore recognised on a </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs94\">percentage of completion basis over time as the processes are carried out using the Input Method under IFRS. Pr<span class=\"_ _25\"></span>ogress is determined </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs95\">based on the achievement of veri\ufb01able stages of the process with incremental adjustments made based on the percentage of completion </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs96\">of the next unachieved veri\ufb01able stage. The gross amount due from clients, on all partnerships with regards to biopr<span class=\"_ _25\"></span>ocessing batches in </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs97\">progress for which costs incurred plus recognised pr<span class=\"_ _25\"></span>o\ufb01ts exceed progress billings, is presented separa<span class=\"_ _25\"></span>tely as a contract asset within the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs98\">note to T<span class=\"_ _27\"></span>rade and Other receivables as presented in the statement of \ufb01nancial position.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs99\">Consideration received in excess of the stage of completion will be deferr<span class=\"_ _25\"></span>ed until such time as it is appropriate to recognise the revenue. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs9a\">The Group has determined that its contracts with clients do not contain a signi\ufb01cant \ufb01nancing component.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs9b\">Revenues for providing process development activities to clients are recognised during the period in which the service is r<span class=\"_ _25\"></span>endered on<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws10 gs9c\">a percentage of completion basis over time as the processes are carried out. The process development activities ar<span class=\"_ _25\"></span>e recognized over time </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs9d\">as the activities create an asset that has no alternative use to the Group and the Group has an en<span class=\"_ _25\"></span>forceable right to payment for the work </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs9e\">packages within the process development activity completed to date.</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs9f\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Oxford Biomedica (UK) Ltd makes use of the output method under IFRS with revenue being r<span class=\"_ _25\"></span>ecognised based on the achievement<span class=\"ls1\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa0\">of veri\ufb01able stages of the process. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gsa1\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Oxford Biomedica Solutions makes use of the input method under IFRS with revenue being r<span class=\"_ _25\"></span>ecognised based on the labour and other </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa2\"><span class=\"_ _2b2\">resources expended to provide the services as a percentage of the total expected eff</span><span class=\"_ _25\"></span>ort to complete the services. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa3\">T<span class=\"_ _27\"></span>echnology licences that have been established by the Group have all been determined as \u201cright to use\u201d licences, rather than \u201cright to </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa4\">access\u201d licences. As such, the revenue from these licences is recognised at the point in time at which the licence transfers to the client.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa5\">The granting of the technology licences to the Group\u2019s background intellectual property and know-how constitutes a \u201cright to use\u201d </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa6\">licence as the Group\u2019s clients are able to conduct development work on the licence independent of the Group. The Group is incentivised </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa7\">separately for its performance obligations in relation to development work and milestone payments. The criteria for r<span class=\"_ _25\"></span>ecognising these </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa8\">technology licences as \u201cright to access\u201d licences has therefore not been met.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsa9\">Milestones relating to bioprocessing or process development activities have been identi\ufb01ed as separate perf<span class=\"_ _25\"></span>ormance obligations as<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsaa\">they involve the transfer of a distinct good or service, determined with reference to conditions stipulated in the r<span class=\"_ _25\"></span>elevant agreements<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsab\">or contracts. Each milestone is determined as either binary or non-binary.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsac\">Milestones that are considered to be binary relate to the achievement of speci\ufb01c events ra<span class=\"_ _25\"></span>ther than the provision of, for example, support. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsad\">Milestones related to the achievement of speci\ufb01c deliverables are considered to be binary milestones and will be r<span class=\"_ _25\"></span>ecognised in full once it </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsae\">is deemed highly probable that the obligation will be met.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsaf\">Milestones related to the provision of support services are consider<span class=\"_ _25\"></span>ed to be non-binary Milestones and are recognised on a percentage of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsb0\">completion basis, but taking into account the likelihood of achievement of the deliverable. Amounts receivable on delivery of a milestone </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsb1\">performance obligation represents variable consideration and have been allocated to the r<span class=\"_ _25\"></span>elevant performance obligation.<span class=\"_ _2b2\"> </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gsb2\">Options to technology licences are considered to form part of the technology licence performance obligation and as such ar<span class=\"_ _25\"></span>e recognised </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gsb3\">when the client exercises the option to obtain that licence. Options to technology licences are not considered to be ma<span class=\"_ _25\"></span>terial rights.</div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gsb4\">Product<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsb5\">Product licences that have been established by the Group have all been determined as \u201cright to use\u201d licences, rather than \u201cright to access\u201d </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsb6\">licences. As such, the revenue from these licences is recognised at the point in time at which the licence transfers to the client.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsb7\">The granting of the product licences to the Group\u2019s background intellectual pr<span class=\"_ _25\"></span>operty and know-how constitutes a \u201cright to use\u201d licence </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsb8\">as the Group\u2019s clients are able to conduct development work on the licence independent of the Group. The Group is incentivised </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsb9\">separately for its performance obligations in relation to development work and milestone payments. The criteria for r<span class=\"_ _25\"></span>ecognising these </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsba\">technology licences as \u201cright to access\u201d licences has therefore not been met.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsbb\">Amounts receivable in respect of milestone payments are considered to be separa<span class=\"_ _25\"></span>te performance obligations which are binary and will </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsbc\">be recognised in full once it is deemed highly probable that the speci\ufb01c performance obligations stipulated in the licence agr<span class=\"_ _25\"></span>eement have </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsbd\">been met. Payments linked to \u201csuccess\u201d such as regulatory \ufb01ling or approval, or achievement of speci\ufb01ed sales volumes, ar<span class=\"_ _25\"></span>e recognised<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsbe\">in full when the relevant event has occurred.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsbf\">Non-binary milestones are recognised on a percentage of completion basis in the period in which rela<span class=\"_ _25\"></span>ted costs are incurred, or over<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc0\">the estimated period to completion of the relevant phase of development or associated clinical trials. Amounts receivable on delivery<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc1\">of a milestone performance obligation represents variable consideration and have been alloca<span class=\"_ _25\"></span>ted to the relevant performance obligation.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc2\">Royalty revenue is recognised as the underlying commercial sales of the underlying manufactured pr<span class=\"_ _25\"></span>oduct occur to third parties of our </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc3\">contracted clients.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gsc5\">Cost of sales<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc6\">Cost of sales comprises the cost of bioprocessing clinical product for clients, the cost of client development pr<span class=\"_ _25\"></span>oject activities, and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc7\">royalties arising on clients\u2019 licences.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc8\">The cost of client development project activities includes the labour costs, overheads and other directly attributable material and third </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsc9\">party costs. Costs are recognised as incurred.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsca\">The cost of bioprocessing clinical product for clients includes the raw materials, labour costs, overheads and other directly a<span class=\"_ _25\"></span>ttributable </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gscb\">third party costs. Costs are recognised as incurred.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gscc\">The Group\u2019s products and technologies include technology elements that are licensed from thir<span class=\"_ _25\"></span>d parties. Royalties arising from such </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gscd\">clients\u2019 licences are treated as cost of sales. Where r<span class=\"_ _25\"></span>oyalties due have not been paid they are included in accruals. Where revenue is </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsce\">spread over a number of accounting periods, the royalty attributable to the deferred r<span class=\"_ _25\"></span>evenue is included in prepayments.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gscf\">Research, development and bioprocessing<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd0\">Research, development and bioprocessing expenditure is charged to the statement of compr<span class=\"_ _25\"></span>ehensive income in the period in which<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd1\">it is incurred.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gsd2\">Employee bene\ufb01t costs<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd3\">Employee bene\ufb01t costs, notably holiday pay and contributions to the Group\u2019s de\ufb01ned contribution pension plan, are charged to the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd4\">statement of comprehensive income on an accruals basis. The assets of the pension scheme are held separately fr<span class=\"_ _25\"></span>om those of the Group </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd5\"><span class=\"_ _2b2\">in independently administered funds. The Group does not offer any other post-retir</span><span class=\"_ _25\"></span>ement bene\ufb01ts.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gsd6\">Share based payments<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd7\">The Group\u2019s employee share option schemes, long term incentive plans, a Sharesave scheme and deferr<span class=\"_ _25\"></span>ed bonus plans allow Group </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd8\">employees to acquire shares of the Company subject to certain criteria. The fair value of options granted is recognised as an expense of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsd9\">employment in the statement of comprehensive income with a corresponding increase in equity<span class=\"_ _25\"></span>. The fair value is measured at the date<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsda\">of grant and spread over the period during which the employees become unconditionally entitled to the options where the options are </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsdb\">not nil cost options. Nil cost options are valued at the market price on the date of grant of the options. The fair value of options granted </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsdc\">under the share option schemes and share save scheme is measured using the Black-<span class=\"_ _27\"></span>Scholes model. The fair value of options granted<span class=\"_ _2\"></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsdd\">under the L<span class=\"_ _3\"></span>TIP schemes, which includes market condition performance criteria, is measured using a Monte Carlo model taking into </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsde\">account the performance conditions under which the options were granted. The fair value of options granted under the deferred bonus </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsdf\">plan is based on the market value of the underlying shares at the date of grant of these options.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse0\">At each \ufb01nancial year end, the Group revises its estimate of the number of options that ar<span class=\"_ _25\"></span>e expected to become exercisable based on </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse1\">forfeiture such that at the end of the vesting period the cumulative charge r<span class=\"_ _25\"></span>e\ufb02ects the actual options that have vested, with no charge<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse2\">for those options which were forfeit prior to vesting. When share options ar<span class=\"_ _25\"></span>e exercised the proceeds received are cr<span class=\"_ _25\"></span>edited to equity.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse3\">Options over the Company\u2019s shares have been awarded to employees of Oxford Biomedica (UK) Ltd. In accor<span class=\"_ _25\"></span><span class=\"_ _2b2\">dance with IFRS 2 \u2019Share-<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse4\"><span class=\"_ _2b2\">based Payments\u2019, the expense in respect of these awards is recognised in the subsidiaries\u2019 \ufb01nancial statements. In accordance with IFRS 2 </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse5\">the Company has treated the awards as a capital contribution to the subsidiaries, resulting in an increase in the cost of investment and a </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse6\">corresponding credit to reserves.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gse7\">Employee Bene\ufb01t T<span class=\"_ _27\"></span>rust<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse8\">The Oxford Biomedica Employee Bene\ufb01t T<span class=\"_ _27\"></span>rust (EBT) has been set up to hold market-purchased shares to settle the 2013 Deferred Bonus </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gse9\">Share Awards made to Executive Directors and employees. Within the Company \ufb01nancial sta<span class=\"_ _25\"></span>tements, the investment in the Oxford </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsea\">Biomedica Employee T<span class=\"_ _27\"></span>rust forms part of the Investments and loans in subsidiary, taking the form o<span class=\"_ _25\"></span>f a loan to subsidiaries. The EBT is </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gseb\">consolidated within the Group \ufb01nancial statements.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse wsd gsec\">Leases<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gsed\">As a lessee<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsee\">At commencement or on modi\ufb01cation of a contract that contains a lease component, the Group allocates the consideration in the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsef\">contract to each lease component on the basis of its relative stand-alone prices. However<span class=\"_ _3\"></span>, for the leases of property, the Group has </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf0\">elected not to separate non-lease components, and to account for the lease and non-lease components as a single lease component.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf1\">The Group recognises a right-of-use asset and a lease liability at the lease commencement date. The right-of-use asset is initially </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf2\">measured at cost, which comprises the initial amount of the lease liability adjusted for any lease payments made at or before the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf3\">commencement date, plus any initial direct costs incurred, and an estimate of costs to dismantle and remove the underlying asset, <span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf4\">or to restore the underlying asset or site on which it is located, less any lease incentives received.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf5\">The right-of-use asset is subsequently depreciated using the straight-line method, from the commencement date to the end of the lease </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf6\">term, unless the lease transfers ownership of the underlying asset to the Group by the end of the lease term, or the cost of the right-of-<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf7\">use asset re\ufb02ects that the Group will exercise a pur<span class=\"_ _25\"></span>chase option. In that case, the right-of-use asset will be depreciated over the useful life </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf8\">of the underlying asset, which is determined on the same basis as those of property and equipment. In addition, the right-of-use asset is </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gsf9\">periodically reduced by impairment losses, if any<span class=\"_ _25\"></span>, and adjusted for certain re-measurements of the lease liability<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div>The lease liability is initially measured at the present value of the lease payments that are not paid a<span class=\"_ _25\"></span>t the commencement date, discounted<span class=\"_ _2b2\"> </span>using the interest rate implicit in the lease or<span class=\"_ _25\"></span>, if that rate cannot be readily determined, the Group\u2019s incr<span class=\"_ _25\"></span>emental borrowing rate. Generally<span class=\"_ _25\"></span>,<span class=\"_ _2b2\"> </span>the Group uses its incremental borrowing rate as the discount rate.<span class=\"_ _2b2\"> </span>The Group determines its incremental borrowing rate by obtaining relevant inter<span class=\"_ _25\"></span>est rates from external \ufb01nancing sources and makes<span class=\"_ _2b2\"> </span>certain adjustments to re\ufb02ect the terms of the lease and the type of the asset leased.<span class=\"_ _2b2\"> </span>Lease payments included in the measurement of the lease liability comprise \ufb01xed payments.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The lease liability is measured at amortised cost using the effective interest method. It is re-measur</span><span class=\"_ _25\"></span>ed if:<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">there is a change in the Group\u2019s estimate of the amount expected to be payable under a residual futur<span class=\"_ _25\"></span>e lease payments;<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the Group changes its assessment of whether it will exercise a purchase, extension or termina<span class=\"_ _25\"></span>tion options; or<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">there is a revised in-substance \ufb01xed lease payment.<span class=\"_ _2b2\"> </span></span>If a lease liability is re-measured, a corresponding adjustment is made to the carrying amount of the right-of-use asset, or is r<span class=\"_ _25\"></span>ecorded in<span class=\"_ _2b2\"> </span>the Pro\ufb01t or Loss if the carrying amount of the right-of-use asset has been reduced to zer<span class=\"_ _25\"></span>o.<span class=\"_ _2b2\"> </span>The Group presents right-of-use assets in \u2019property<span class=\"_ _25\"></span>, plant and equipment\u2019 and lease liabilities as a category on the face of the Statement<span class=\"_ _2b2\"> </span>of Financial Position.<span class=\"_ _2b2\"> </span>Short term or low-value leases<span class=\"_ _2b2\"> </span>The Group has elected not to recognise right-of-use assets and lease liabilities of short term and low-value leases. The Group r<span class=\"_ _25\"></span>ecognises<span class=\"_ _2b2\"> </span>lease payments associated with these leases as an expense on a straight-line basis over the lease term.<span class=\"_ _2b2\"> </span>Sales &amp; Leaseback<span class=\"_ _2b2\"> </span>A sale and leaseback is where the Group sells an asset and immediately reacquires the use o<span class=\"_ _25\"></span>f the asset by entering into a lease with the<span class=\"_ _2b2\"> </span>buyer<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>For sale and operating leasebacks, generally the assets are sold at fair value, and accordingly the pro\ufb01ts and loss fr<span class=\"_ _25\"></span>om the sale arerecognised immediately in the Statement of Pro\ufb01t and loss. The fair value is determined by obtaining a valua<span class=\"_ _25\"></span>tion from an independentproperty valuation \ufb01rm.A sale occurs when control of the underlying asset passes to the buyer<span class=\"_ _25\"></span>. A lease liability is recognised, the associated property<span class=\"_ _3\"></span>, plant<span class=\"_ _2\"></span> and equipment asset is derecognised, and a right of use asset is recognised at the proportion of the carrying value r<span class=\"_ _25\"></span>elating to the right<span class=\"_ _2b2\"> </span>retained. Any gain or loss arising relates to the rights transferred to the buyer<span class=\"_ _3\"></span>.<span class=\"_ _2b2\"> </span>Grants<span class=\"_ _2b2\"> </span>Income from government and other grants is recognised over the period necessary to match them with the related costs which they<span class=\"_ _2b2\"> </span>are intended to compensate. Grant income is included as other operating income within the statement of comprehensive income, and<span class=\"_ _2b2\"> </span>the related costs are included within research, development and biopr<span class=\"_ _25\"></span>ocessing costs, and administrative expenses. Where grant income<span class=\"_ _2b2\"> </span>received exceeds grant income recognised, it is included within deferred income on the S<span class=\"_ _25\"></span>tatement of \ufb01nancial position, whereas grant<span class=\"_ _2b2\"> </span>income recognised exceeds grant income received, it is included within accrued income on the Statement of \ufb01nancial position.<span class=\"_ _2b2\"> </span>Finance income and costs<span class=\"_ _2b2\"> </span>Finance income and costs comprise interest income and interest payable during the year<span class=\"_ _25\"></span><span class=\"_ _2b2\">, calculated using the effective interest rate<span class=\"_ _2b2\"> </span></span>method. It also includes the revaluation of external loans denominated in a foreign curr<span class=\"_ _25\"></span>ency.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Financing expenses include interest payable and \ufb01nance charges on lease liabilities recognised in pro\ufb01t or loss using the effective inter</span><span class=\"_ _25\"></span>est<span class=\"_ _2b2\"> </span>method and unwinding of the discount on provisions.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Interest income and interest payable is recognised in pro\ufb01t or loss as it accrues, using the eff</span><span class=\"_ _25\"></span>ective interest method.<span class=\"_ _2b2\"> </span>T<span class=\"_ _3\"></span>axation<span class=\"_ _2b2\"> </span>In 2022 and before, the Group was entitled to claim tax credits in the United Kingdom for certain r<span class=\"_ _25\"></span>esearch and development expenditure.<span class=\"_ _2b2\"> </span>The Group receives a Research and Development Expenditure Cr<span class=\"_ _25\"></span>edit (\u2019RDEC\u2019) which is accounted for as a reduction in research and<span class=\"_ _2b2\"> </span>development costs in the statement of comprehensive income, and within trade and other receivables in the Statement of \ufb01nancial<span class=\"_ _2b2\"> </span>position. The credit is paid in arrears once tax returns have been \ufb01led and agreed.<span class=\"_ _2b2\"> </span>Current tax, including UK corporation tax and foreign tax, is provided at amounts expected to be paid (or r<span class=\"_ _25\"></span>ecovered) using the tax rates<span class=\"_ _2b2\"> </span>and laws that have been enacted, or substantially enacted, by the Statement of \ufb01nancial position date.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Deferred tax is calculated in respect of all temporary differ</span><span class=\"_ _25\"></span>ences identi\ufb01ed at the Statement of \ufb01nancial position date except for: the<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">initial recognition of goodwill; the initial recognition of assets or liabilities that affect neither accounting nor taxable pr</span><span class=\"_ _25\"></span>o\ufb01t other than in<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">a business combination, and differences relating to investments in subsidiaries to the extent that they will pr</span><span class=\"_ _25\"></span>obably not reverse in the<span class=\"_ _2b2\"> </span>foreseeable future.<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span><span class=\"_ _2b2\">emporary differences are differences between the carrying amount of the Group\u2019s assets and liabilities and their tax base. Deferred tax<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">liabilities may be offset against deferred tax assets within the same taxable entity or qualifying local tax group. Any remaining deferr</span><span class=\"_ _25\"></span>ed<span class=\"_ _2b2\"> </span>tax asset is recognised only when, on the basis of all available evidence, it can be regarded as probable tha<span class=\"_ _25\"></span>t there will be suitable taxable<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">pro\ufb01ts within the same jurisdiction in the foreseeable future against which the deductible temporary differ</span><span class=\"_ _25\"></span>ence can be utilised.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs131\">Deferred tax is measured at the average tax rates that ar<span class=\"_ _25\"></span>e expected to apply in the periods in which the asset is realised or liability settled, </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs132\">based on tax rates and laws that have been enacted or substantially enacted by the Statement of \ufb01nancial position date.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs133\">Measurement of deferred tax liabilities and assets re\ufb02ects the tax consequence expected to fall fr<span class=\"_ _25\"></span>om the manner in which the asset<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs134\">or liability is recovered or settled.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs135\">Property, plant and equipment<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs136\">Property<span class=\"_ _25\"></span>, plant and equipment are carried at cost, together with any incidental expenses of acquisition, less depreciation. Cost includes </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs137\">the original purchase price of the asset and any costs attributable to bringing the asset to its working condition for its intended use.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs138\"><span class=\"_ _2b2\">Depreciation is calculated to write off the cost of property</span><span class=\"_ _3\"></span>, plant and equipment less their estimated residual values on a straight-line<span class=\"_ _2\"></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs139\">basis over the expected useful economic lives of the assets concerned. Depreciation of an asset begins when it is available for use. The </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs13a\">principal annual rates used for this purpose are:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs13b\">Freehold property<span class=\"_ _1d6\"> </span><span class=\"wsa\">10%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs13c\">Leasehold improvements<span class=\"_ _148\"> </span><span class=\"wsa\">10%</span><span class=\"ls1\"> </span></div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls0 ws0 gs13d\">(over the remaining lease term if shorter)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs13e\"><span class=\"_ _2b2\">Office equipment and computers</span><span class=\"_ _1d7\"> </span><span class=\"wsa\">20\u201333%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs13f\">Bioprocessing and laboratory equipment<span class=\"_ _1d8\"> </span><span class=\"wsa\">20%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs140\">The assets\u2019 residual values and useful lives are reviewed annually<span class=\"_ _25\"></span>. Residual values are set at zero and will be r<span class=\"_ _25\"></span>eassessed should the asset\u2019s </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs141\">selling price exceed its net book value.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs142\">The bioprocessing plants are reviewed annually for impairment triggers and, where necessary<span class=\"_ _3\"></span>, a full impairment review is performed.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs143\">Assets under construction are capitalised throughout the course of the construction period with depreciation starting once the asset is </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs144\">available for use.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs145\">Assets capitalised under a category of \ufb01xed assets may be transferred to another category within \ufb01x<span class=\"_ _25\"></span>ed assets if, upon review, it is identi\ufb01ed </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs146\">that the asset is more appropriately identi\ufb01able with that other category of \ufb01x<span class=\"_ _25\"></span>ed asset.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs147\">Intangible assets &amp; Goodwill<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs148\">Recognition and measurement<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs149\">Goodwill<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs14a\">Goodwill arising on the acquisition of subsidiaries is measured at cost less accumulated impairment losses.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs14b\">Developed technology<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs14c\">Developed technology acquired by the Group (see note 11) has a \ufb01nite useful life. It is measured at cost less </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs14d\">accumulated amortisation and any accumulated impairment losses.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs14e\">Patents<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs14f\">Patents have \ufb01nite useful lives and are measured at cost less accumulated amortisation and <span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs150\">any accumulated impairment losses.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs151\">Subsequent expenditure<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs152\">Subsequent expenditure is capitalised only when it increases the future economic bene\ufb01ts embodied in the speci\ufb01c asset to which </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs153\">it relates. All other expenditure, including expenditure on internally generated goodwill and brands, is r<span class=\"_ _25\"></span>ecognised in pro\ufb01t or loss as </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs154\">incurred.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs155\">Cash generating unit (CGU)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs156\">A cash generating unit is the smallest group of assets that independently generates cash \ufb02ow and whose cash \ufb02ow is largely independent </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs157\">of the cash \ufb02ows generated by other assets.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gs158\">Amortisation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs159\"><span class=\"_ _2b2\">Amortisation is calculated to write off the cost of intangible assets less their estimated residual values using the straight-line method over </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs15a\">their estimated useful lives, and is generally recognised in pro\ufb01t or loss. Goodwill is not amortised. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs15b\">The estimated useful lives for current and comparative periods are as follows: </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs15c\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">patents: 3\u201320 years</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs15d\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">developed technology: 15 years<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs15e\">Amortisation methods, useful lives and residual values are reviewed at each r<span class=\"_ _25\"></span>eporting date and adjusted if appropriate.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gs15f\">Impairment<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs160\">The carrying value of non-\ufb01nancial assets is reviewed annually for impairment, or earlier if an indication of impairment occurs, and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs161\"> <span class=\"_ _32\"></span>provision made where appropriate. Charges or cr<span class=\"_ _25\"></span>edits for impairment are passed through the statement of comprehensive income.<span class=\"_ _2b2\"> </span></div>For the purposes of assessing impairments, assets are grouped at the lowest levels for which there ar<span class=\"_ _25\"></span>e separately identi\ufb01able cash \ufb02ows or<span class=\"_ _2b2\"> </span>cash-generating units. Impairment losses are recognised for the amount by which each asset\u2019s carrying amount exceeds its r<span class=\"_ _25\"></span>ecoverable<span class=\"_ _2b2\"> </span>amount. The recoverable amount is the higher of an asset\u2019s fair value less costs to sell, and value in use. V<span class=\"_ _25\"></span>alue in use is calculated using<span class=\"_ _2b2\"> </span>estimated discounted future cash \ufb02ows. The key assumptions used in calculating the discounted future cash \ufb02ows ar<span class=\"_ _25\"></span>e management<span class=\"_ _2b2\"> </span>estimates, based where possible on available market informa<span class=\"_ _25\"></span>tion and information for similar products.<span class=\"_ _2b2\"> </span>Impairment and amortisation charges are included within research, development and biopr<span class=\"_ _25\"></span>ocessing costs in the statement of<span class=\"_ _2b2\"> </span>comprehensive income.<span class=\"_ _2b2\"> </span>Intellectual property rights comprise third party patent rights or rights to market commercial pr<span class=\"_ _25\"></span>oducts for key therapeutic indications that<span class=\"_ _2b2\"> </span>have been purchased by the Group.<span class=\"_ _2b2\"> </span>Investments in subsidiaries<span class=\"_ _2b2\"> </span>Investments are carried at cost less any provision made for impairment. Options over the Company\u2019s shares have been awar<span class=\"_ _25\"></span>ded to<span class=\"_ _2b2\"> </span>employees of subsidiary companies. In accordance with IFRS2, the Company treats the value of these awards as a capital contribution<span class=\"ls1\"> </span>to the subsidiaries, resulting in an increase in the cost of investment.<span class=\"_ _2b2\"> </span>Investments in subsidiary undertakings, including shares and loans, are carried at cost less any impairment provision. Such investments are<span class=\"_ _2b2\"> </span>subject to review, and any impairment is charged to the statement o<span class=\"_ _25\"></span>f comprehensive income.<span class=\"_ _2b2\"> </span>At each year end the Directors review the carrying value of the Company\u2019s investment in subsidiaries. Where ther<span class=\"_ _25\"></span>e is a material and<span class=\"_ _2b2\"> </span>sustained shortfall in the market capitalisation, or a signi\ufb01cant and sustained change in the business resulting in a decrease in mark<span class=\"_ _25\"></span>et<span class=\"_ _2b2\"> </span>capitalisation, the Directors consider this to be a trigger of an impairment review as set out in IAS 36<span class=\"_ _25\"></span>, and the carrying value of the<span class=\"_ _2b2\"> </span>Company\u2019s investments in subsidiaries is adjusted. The Directors consider that reference to the mark<span class=\"_ _25\"></span>et capitalisation of the Group<span class=\"ls1\"> </span>is an appropriate external measure of the value of the Company\u2019s subsidiaries for this purpose.<span class=\"_ _2b2\"> </span>At year end the Directors will assess the requirement to write back a portion or all of any impairment pr<span class=\"_ _25\"></span>eviously recognised on its<span class=\"_ _2b2\"> </span>investment in subsidiaries. Factors which will be taken into account with regar<span class=\"_ _25\"></span>d to this decision will be the Groups track record of<span class=\"_ _2b2\"> </span>improved \ufb01nancial results across the last three to four years, as well as the expecta<span class=\"_ _25\"></span>tion of future impairments being required after a write<span class=\"_ _2b2\"> </span>back was accounted for<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>Financial assets<span class=\"_ _2b2\"> </span>Assets at fair value through pro\ufb01t and loss<span class=\"_ _2b2\"> </span>The gain or loss on Assets at fair value through pro\ufb01t and loss is recognised in the statement o<span class=\"_ _25\"></span>f comprehensive income.<span class=\"_ _2b2\"> </span>Investments<span class=\"_ _2b2\"> </span>Other investments held by the Group are classi\ufb01ed as at fair value through pro<span class=\"_ _25\"></span>\ufb01t and loss.<span class=\"_ _2b2\"> </span>Bank deposits<span class=\"_ _2b2\"> </span>Bank deposits with original maturities between three months and twelve months are included in current assets and are valued<span class=\"ls1\"> </span>at amortised cost.<span class=\"_ _2b2\"> </span>Financial instruments<span class=\"_ _2b2\"> </span>Classi\ufb01cation<span class=\"_ _2b2\"> </span>On initial recognition, a \ufb01nancial asset is classi\ufb01ed as measured at: amortised cost; FVOCI \u2013 debt investment; FVOCI \u2013 equity investment;<span class=\"_ _2b2\"> </span>or FVTPL. Financial assets are not reclassi\ufb01ed subsequent to their initial recognition unless the Company changes its business model for<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">managing \ufb01nancial assets in which case all affected \ufb01nancial assets are reclassi\ufb01ed on the \ufb01rst day of the \ufb01rst reporting period f</span><span class=\"_ _25\"></span>ollowing<span class=\"_ _2b2\"> </span>the change in the business model.<span class=\"_ _2b2\"> </span>A \ufb01nancial asset is measured at amortised cost if it meets both of the following conditions and is not designated as at FVTPL:<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">it is held within a business model whose objective is to hold assets to collect contractual cash \ufb02ows; and<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">its contractual terms give rise on speci\ufb01ed dates to cash \ufb02ows that are solely payments of principal and interest on the principal<span class=\"_ _2b2\"> </span></span>amount outstanding.<span class=\"_ _2b2\"> </span>A debt investment is measured at FVOCI if it meets both of the following conditions and is not designated as at FVTPL:<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">it is held within a business model whose objective is achieved by both collecting contractual cash \ufb02ows and selling \ufb01nancial assets;<span class=\"_ _2b2\"> </span></span>and<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">its contractual terms give rise on speci\ufb01ed dates to cash \ufb02ows that are solely payments of principal, and interest on the principal<span class=\"_ _2b2\"> </span></span>amount outstanding.<span class=\"_ _2b2\"> </span>On initial recognition of an equity investment that is not held for trading, the Company may irrevocably elect to present subsequent<span class=\"_ _2b2\"> </span>changes in the investment\u2019s fair value in OCI. This election is made on an investment-by-investment basis.<span class=\"_ _2b2\"> </span>All \ufb01nancial assets not classi\ufb01ed as measured at amortised cost or FVOCI as described above, are measured at FVTPL. This includes<span class=\"_ _2b2\"> </span>all derivative \ufb01nancial assets. On initial recognition, the Group may irrevocably designate a \ufb01nancial asset that otherwise meets the<span class=\"_ _2b2\"> </span>requirements to be measured at amortised cost or at FVOCI<span class=\"_ _25\"></span>, as at FVTPL if doing so eliminates, or signi\ufb01cantly reduces an accounting<span class=\"_ _2b2\"> </span>mismatch that would otherwise arise.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gs199\">Derecognition<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs19a\">Financial assets<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs19b\">The Group derecognises a \ufb01nancial asset when:</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs19c\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the contractual rights to the cash \ufb02ows from the \ufb01nancial asset expire; or</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs19d\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">it transfers the rights to receive the contractual cash \ufb02ows in a transaction in which either; or</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs19e\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">substantially all of the risks and rewards of ownership of the \ufb01nancial asset are transf<span class=\"_ _25\"></span>erred; or</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs19f\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the Group neither transfers nor retains substantially all of the risks and rewar<span class=\"_ _25\"></span>ds of ownership, and it does not retain control of<span class=\"ls1\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a0\">the \ufb01nancial asset.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs1a1\">Financial liabilities<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a2\">The Group derecognises a \ufb01nancial liability when its contractual obligations are discharged or cancelled, or expir<span class=\"_ _25\"></span>e. The Group also </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a3\"><span class=\"_ _2b2\">derecognises a \ufb01nancial liability when its terms are modi\ufb01ed and the cash \ufb02ows of the modi\ufb01ed liability are substantially differ</span><span class=\"_ _25\"></span>ent, in which </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a4\">case a new \ufb01nancial liability based on the modi\ufb01ed terms is recognised at fair value.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a5\">On derecognition of a \ufb01nancial liability<span class=\"_ _25\"></span><span class=\"_ _2b2\">, the difference between the carrying amount extinguished and the consideration paid (including </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a6\">any non-cash assets transferred or liabilities assumed), is recognised in pro\ufb01t or loss.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse wsd gs1a7\">Inventories<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a8\">Inventories are stated at the lower of cost and net realisable value. Cost is determined using the weighted average method. It ex<span class=\"_ _25\"></span>cludes </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1a9\">borrowing costs. Net realisable value is the estimated selling price in the ordinary course of business, less applicable variable selling </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs1aa\">expenses.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1ab\">T<span class=\"_ _3\"></span>rade receivables<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ac\">T<span class=\"_ _27\"></span>rade receivables are recognised initially at the transaction price as these assets do not have signi\ufb01cant \ufb01nancing components, and are </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ad\">subsequently measured at amortised cost. The Group recognises loss allowances for r<span class=\"_ _25\"></span>eceivables under the expected credit loss model<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ae\">as established by evidence that the Group will not be able to collect all amounts due according to the original terms of the receivables.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1af\">Cash and cash equivalents<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1b0\">Cash and cash equivalents include cash in hand, bank deposits repayable on demand, and other short term highly liquid investments with </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1b1\">original maturities of three months or less.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse wsd gs1b2\">Deposits<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1b3\">Deposits consist of amounts held in escrow and is included within other receivables within the Statement of \ufb01nancial position until such </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1b4\">time as the restrictions relating to those amounts have been lifted.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1b5\">T<span class=\"_ _3\"></span>rade payables<span class=\"_ _2b2\"> </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs1b6\">T<span class=\"_ _27\"></span><span class=\"_ _2b2\">rade payables are recognised initially at fair value and subsequently measured at amortised cost using the effective interest method.</span><span class=\"ls1\"> </span></div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs1b7\">T<span class=\"_ _27\"></span>rade payables are classi\ufb01ed as current liabilities if payment is due within one year or less. If not, they are presented as non-current liabilities.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1b8\">Contract liabilities<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1b9\">Contract liabilities primarily relate to the advance consideration received from clients for commer<span class=\"_ _25\"></span>cial development work and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ba\">bioprocessing batches, as well as options and funded research and development activities.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1bb\">Deferred income<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1bc\">Deferred income primarily relates to the advance consideration received f<span class=\"_ _25\"></span>or grants and lease incentives.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse wsd gs1bd\">Provisions<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1be\">Provisions for dilapidation costs and other potential liabilities are recognised when the Gr<span class=\"_ _25\"></span>oup has a present legal or constructive </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1bf\">obligation as a result of past events; it is probable that an out\ufb02ow of r<span class=\"_ _25\"></span>esources will be required to settle the obligation; and the amount </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1c0\">has been reliably estimated. Provisions are not recognised f<span class=\"_ _25\"></span>or future operating losses.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1c1\">Provisions are measured at the present value o<span class=\"_ _25\"></span>f the expenditure expected to be required to settle the obligation using the 3 year historic </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1c2\">in\ufb02ation rate. The increase in the provision due to the passage of time is r<span class=\"_ _25\"></span>ecognised as a \ufb01nance cost.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1c3\">Share capital<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1c4\">Ordinary shares are classi\ufb01ed as equity<span class=\"_ _25\"></span>. Costs of share issues are charged to the shar<span class=\"_ _25\"></span>e premium account.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1c5\">Merger reserve<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1c6\">A merger reserve is used where more than 90% of the shar<span class=\"_ _25\"></span>es in a subsidiary are acquired and the consideration includes the issue of new </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1c7\">shares by the Company<span class=\"_ _25\"></span>, thereby attracting merger relief under s612 and s613 of the Companies Act 2006<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div>Business combinations<span class=\"_ _2b2\"> </span>The Group accounts for business combinations using the acquisition method when the acquired set of activities and assets meets<span class=\"_ _2b2\"> </span>the de\ufb01nition of a business and control is transferred to the Group. In determining whether a particular set of activities and assets is a<span class=\"_ _2b2\"> </span>business, the Group assesses whether the set of assets and activities acquired includes, at a minimum, an input and substantive process,<span class=\"_ _2b2\"> </span>and whether the acquired set has the ability to produce outputs. The Group has an option to apply a \u2019concentration test\u2019 that permits<span class=\"_ _2b2\"> </span>a simpli\ufb01ed assessment of whether an acquired set of activities and assets is not a business. The optional concentration test is met if<span class=\"_ _2b2\"> </span>substantially all of the fair value of the gross assets acquired is concentrated in a single identi\ufb01able asset or group o<span class=\"_ _25\"></span>f similar identi\ufb01able<span class=\"_ _2b2\"> </span>assets. The consideration transferred in the acquisition is generally measured at fair value, as are the identi\ufb01able net assets acquir<span class=\"_ _25\"></span>ed.<span class=\"_ _2b2\"> </span>Any goodwill that arises is tested annually for impairment. Any gain on a bargain purchase is recognised in pro<span class=\"_ _25\"></span>\ufb01t or loss immediately.<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>ransaction costs are expensed as incurred, except if related to the issue of debt or equity securities.<span class=\"_ _2b2\"> </span>The consideration transferred does not include amounts related to the settlement of pr<span class=\"_ _25\"></span>e-existing relationships. Such amounts are<span class=\"_ _2b2\"> </span>generally recognised in pro\ufb01t or loss.<span class=\"_ _2b2\"> </span>Non-controlling interests (NCI)<span class=\"_ _2b2\"> </span>NCI are measured initially at the Group\u2019s proportiona<span class=\"_ _25\"></span>te interest in the recognised amount of the identi\ufb01able assets and liabilities of the<span class=\"_ _2b2\"> </span>acquiree. NCI are measured subsequently at their proportiona<span class=\"_ _25\"></span>te share of the subsidiary\u2019s net assets at the reporting date. Changes in the<span class=\"_ _2b2\"> </span>Group\u2019s interest in a subsidiary that do not result in a loss of contr<span class=\"_ _25\"></span>ol are accounted for as equity transactions.<span class=\"_ _2b2\"> </span>When a foreign operation is disposed of in its entirety<span class=\"_ _25\"></span>, or partially such that control, signi\ufb01cant control or joint contr<span class=\"_ _25\"></span>ol, is lost, the<span class=\"_ _2b2\"> </span>cumulative amount in the translation reserve related to the for<span class=\"_ _25\"></span>eign operation is reclassi\ufb01ed to pro\ufb01t or loss as part of the gain or loss on<span class=\"_ _2b2\"> </span>disposal. If the Group disposes of part of its interest in a subsidiary but retains contr<span class=\"_ _25\"></span>ol, then the relevant proportion of the cumulative<span class=\"_ _2b2\"> </span>amount is reattributed to NCI. When the Group disposes o<span class=\"_ _25\"></span>f only part of an associate or joint venture while retaining signi\ufb01cant in\ufb02uence<span class=\"_ _2b2\"> </span>or joint control, the relevant proportion of the cumulative amount is r<span class=\"_ _25\"></span>eclassi\ufb01ed to pro\ufb01t or loss.<span class=\"_ _2b2\"> </span>Financial liability: loans<span class=\"_ _2b2\"> </span>On initial recognition, external loans are measured at fair value plus directly a<span class=\"_ _25\"></span>ttributable transaction costs. On subsequent measurement,<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">external loans are measured at amortised cost under the effective interest rate method. The eff</span><span class=\"_ _25\"></span>ective interest rate method is a method<span class=\"_ _2b2\"> </span>of calculating the amortised cost of a \ufb01nancial liability and allocating the interest expense over the relevant period. The calculation o<span class=\"_ _25\"></span>f the<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">effective interest rate takes into account the estimated cash \ufb02ows which consider all the contractual terms of the \ufb01nancial instrument,<span class=\"_ _2b2\"> </span></span>including any embedded derivatives which are not subject to separation.<span class=\"_ _2b2\"> </span>Financial liability: Put Options<span class=\"_ _2b2\"> </span>Where a put option with non-controlling shareholders (NCI) exists on their equity interests, a liability for the fair value o<span class=\"_ _25\"></span>f the exercise price<span class=\"_ _2b2\"> </span>of the option is recognised.<span class=\"_ _2b2\"> </span>Management have assessed that the NCI still have access to the returns associated with the underlying ownership interests, and have<span class=\"_ _2b2\"> </span>therefore chosen to apply the present access method under which the corresponding entry is r<span class=\"_ _25\"></span>ecognised in Other Equity. As r<span class=\"_ _25\"></span>equired by<span class=\"_ _2b2\"> </span>IFRS, Oxford Biomedica has chosen to apply an accounting policy<span class=\"_ _25\"></span>, to be applied consistently for all put liabilities: that subsequent to initial<span class=\"_ _2b2\"> </span>recognition, changes in fair value of the put liability will be recognised in equity<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>The value of the put liability is determined using a Monte Carlo simulation which calculates the expected future exercise value o<span class=\"_ _25\"></span>f the put<span class=\"_ _2b2\"> </span>option, taking into consideration Oxford Biomedica Solutions\u2019 forecasted cash \ufb02ows over the period up until the expected exer<span class=\"_ _25\"></span>cise date<span class=\"_ _2b2\"> </span>along with the expected volatility of those cash \ufb02ows over that same period. The expected future exercise value is then discounted to<span class=\"ls1\"> </span>the present using a discount rate in order to capture the counter party risk of the expected payment. The discount rate may be impacted<span class=\"_ _2b2\"> </span>by economic and market factors as well as changes to the risk free rate of return which impacts debt borr<span class=\"_ _25\"></span>owing rates.<span class=\"_ _2b2\"> </span>2, Critical accounting judgements and estimates<span class=\"_ _2b2\"> </span>In applying the Group\u2019s accounting policies, management is required to make judgements and assumptions concerning the futur<span class=\"_ _25\"></span>e in<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">a number of areas. Actual results may be different fr</span><span class=\"_ _25\"></span>om those estimated using these judgements and assumptions. The key sources of<span class=\"_ _2b2\"> </span>estimation uncertainty and the critical accounting judgements that have a signi\ufb01cant risk of causing a material adjustment to the carrying<span class=\"_ _2b2\"> </span>amounts of assets and liabilities within the next \ufb01nancial year are discussed below.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs1f6\">Key accounting matters<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse wsd gs1f7\">Judgements<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs1f8\">Contract revenues: Identi\ufb01cation of performance obligations, allocation of revenue and timing of revenue recognition<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1f9\">The Group has identi\ufb01ed three key areas of judgement within the collabora<span class=\"_ _25\"></span>tion agreements entered into during the period. Firstly<span class=\"_ _25\"></span>, in </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1fa\">relation to the number of distinct performance obligations contained within each collaboration agreement; secondly the fair value </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1fb\">allocation of revenue to each performance obligation; and thirdly the timing of r<span class=\"_ _25\"></span>evenue recognition based on the achievement of the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1fc\">relevant performance obligation. The sales royalties contained within the collaboration agreements qualify f<span class=\"_ _25\"></span>or the royalty exemption </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1fd\"><span class=\"_ _2b2\">available under IFRS 15 and will only be recognised as the underlying sales are made even though the performance obligation, in terms</span><span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1fe\">of the technology licence, has already been met.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs1ff\">The judgements with regards to the number of distinct performance obligations and the fair value allocation of r<span class=\"_ _25\"></span>evenue to each </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs200\">performance obligation takes place on a contract-by-contract basis across numerous contracts enter<span class=\"_ _25\"></span>ed into by the Group. As these </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs201\"><span class=\"_ _2b2\">judgements take place across numerous contracts, each with differ</span><span class=\"_ _25\"></span>ent characteristics, it is not practical to provide a quantitative analysis </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs202\"><span class=\"_ _2b2\">of the impact of applying different judgements, and the Directors do not believe that disclosing a range of outcomes r</span><span class=\"_ _25\"></span>esulting from </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs203\"><span class=\"_ _2b2\">applying different judgements provides meaningful information to the r</span><span class=\"_ _25\"></span>eader of the \ufb01nancial statements. Consequently<span class=\"_ _25\"></span>, no quantitative </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs204\">analysis has been provided for these judgements.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs205\">Number of distinct performance obligations<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs206\">Upon review of certain client contracts and preparation of accounting papers setting out the accounting trea<span class=\"_ _25\"></span><span class=\"_ _2b2\">tment as per IFRS 15,</span><span class=\"ls1\"> </span></div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs207\">the Group is required to exer<span class=\"_ _25\"></span>cise judgement in identifying the distinct performance obligations contained within the contract. These have </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs208\">been identi\ufb01ed as being:</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs209\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The granting of technology licences</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs20a\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Milestones relating to bioprocessing or process development activities<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs20b\">The fair value allocation of revenue to each performance obligation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs20c\">Because there is no readily available market price for many o<span class=\"_ _25\"></span>f the performance obligations contained in the client contracts, the Group </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs20d\">exercises judgment in estimating the stand alone selling price of each of these performance obligations. K<span class=\"_ _25\"></span>ey areas of judgement are </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs20e\">assessed to be:</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs20f\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The stand alone selling price of technology licences. The Group assesses the stand alone selling price of licences by reference to the </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs210\">stand alone selling price of previously recognised client technology licences, and the size of the mark<span class=\"_ _25\"></span>et of the target indication and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs211\">other market related observable inputs</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs212\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The stand alone selling price of bioprocessing batches. The Group assesses the stand alone selling price of the batches in terms the </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs213\">stand alone selling price of its other client contract batch selling prices</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs214\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The stand alone selling price in terms of the annual full time equivalent rate to charge for process development activities. The Group </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs215\">assesses the full time equivalent rate in terms the stand alone equivalent rate of its other client contract equivalent rates<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs216\">Timing of revenue recognition: technology licence revenues </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs217\">One of the key judgemental areas identi\ufb01ed within the collaboration agreements is the timing of r<span class=\"_ _25\"></span>ecognition of licence revenue based<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs218\">on the achievement of the relevant performance obligation. The individual factors and aspects relating to licence r<span class=\"_ _25\"></span>evenue are assessed as </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs219\"><span class=\"_ _2b2\">part of the IFRS 15 accounting paper prepared for each agreement and a judgement is made as to whether the licence fee perf</span><span class=\"_ _25\"></span>ormance </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs21a\">obligation related to the granting of the licence to the client has been achieved. If it was judged that the performance obligations on </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs21b\">licences granted in 2022 had not been met, revenues would have been \u00a33,385<span class=\"_ _25\"></span>,000 lower with the r<span class=\"_ _25\"></span>evenue expected to be recognised<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs21c\">in future when the performance obligations were deemed to have been met.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs21d\">Modi\ufb01cation of Oaktree loan agreement<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs21e\">When a loan agreement with an existing lender is modi\ufb01ed, a determination has to be made as to whether the modi\ufb01cation is treated </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs21f\">as the extinguishment of the existing \ufb01nancial liability and the recognition of a new liability<span class=\"_ _25\"></span>, or accounting for the modi\ufb01cation of the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs220\">agreement as a modi\ufb01cation to the existing \ufb01nancial liability<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs221\">On 10 March 2022 the Group entered into and drew down an US$85 million loan facility agr<span class=\"_ _25\"></span>eement with Oaktree under a 1 year facility </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs222\">agreement maturing in 2023 with a nominal interest rate on the loan of 8<span class=\"_ _25\"></span>.5%. On 7 October 2022, the Loan Agreement was amended, </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs223\">US$35 million was repaid and the term extended to October 2026, with a variable interest rate which is capped a<span class=\"_ _25\"></span>t 10.25% per annum.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs224\">A substantial modi\ufb01cation under IFRS 9 is deemed to have occurred if the net present value of the cash \ufb02ows under the new terms, </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs225\"><span class=\"_ _2b2\">including any fees, differs by at least 10% from the present value of the r</span><span class=\"_ _25\"></span>emaining cash\ufb02ows under the original terms.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs226\">Management has determined that the modi\ufb01cation of the Oaktree loan agreement on 7 October 2022 does not meet the substantial </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs227\">modi\ufb01cation criteria and therefore will be recognised as a non-substantial modi\ufb01cation to the existing loan, with the loan being r<span class=\"_ _25\"></span>estated </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs228\"><span class=\"_ _2b2\">to its present value and subsequently at amortised cost under the effective interest rate method.<span class=\"_ _2b2\"> </span></span></div>This was determined on the basis of the quantitative test performed as required by IFRS 9 resulting in a 3% change to the net pr<span class=\"_ _25\"></span>esent<span class=\"_ _2b2\"> </span>value of the remaining cash \ufb02ows when compared to the original cash \ufb02ows under the original terms. Management has also performed<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">a qualitative assessment to identify substantial differences in terms that by nature wer</span><span class=\"_ _25\"></span>e not captured by the quantitative assessment.<span class=\"_ _2b2\"> </span>In considering the qualitative factors, Management has considered the payment terms, options, change in other terms and collaterals.<span class=\"_ _2b2\"> </span>Based on the quantitative and qualitative assessment, Management has determined that the modi\ufb01cation of the loan does not meet the<span class=\"_ _2b2\"> </span>substantial modi\ufb01cation criteria.<span class=\"_ _2b2\"> </span>If the Group had concluded that the amendment constitutes a signi\ufb01cant modi\ufb01cation, this accounting treatment would have r<span class=\"_ _25\"></span>esulted<span class=\"ls1\"> </span>in the recognition of a loss on extinguishment of \u00a31,391,<span class=\"_ _25\"></span>000, r<span class=\"_ _25\"></span>ecognition of legal fees of \u00a3439<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>000, and an increase in the loan balance<span class=\"ls1\"> </span>of \u00a3409<span class=\"_ _25\"></span>,000 on the 7th o<span class=\"_ _25\"></span>f October 2022.<span class=\"_ _2b2\"> </span>Estimations<span class=\"_ _2b2\"> </span>The key assumptions concerning the future and other key sources o<span class=\"_ _25\"></span>f estimation uncertainty at the reporting date that have a signi\ufb01cant<span class=\"_ _2b2\"> </span>risk of causing a material adjustment to the carrying amounts of assets and liabilities within the next \ufb01nancial year are discussed below<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The nature of estimation means that actual outcomes could differ from those estima</span><span class=\"_ _25\"></span>tes.<span class=\"_ _2b2\"> </span>Percentage of completion of bioprocessing batch revenues<span class=\"_ _2b2\"> </span>Bioprocessing of clinical/commercial product for clients is r<span class=\"_ _25\"></span>ecognised on a percentage of completion basis over time as the processes arecarried out. Progress is determined based on the achievement of veri\ufb01able stages of the bioprocessing pr<span class=\"_ _25\"></span>ocess. Revenues are recognisedon a percentage of completion basis and as such require estimation in terms of the assessment o<span class=\"_ _25\"></span>f the correct stage of completionincluding the expected costs to completion for that speci\ufb01c bioprocessing batch. The value of the revenue r<span class=\"_ _25\"></span>ecognised with regard to thebioprocessing batches which remain in progress a<span class=\"_ _25\"></span>t year end is\u00a3<span class=\"_ _2b2\"> </span>32,051,<span class=\"_ _25\"></span>000<span class=\"_ _25\"></span>. If the assessed percentage of completion was 10 percentagepoints higher or lower<span class=\"_ _25\"></span>, revenue recognised in the period would have been\u00a3<span class=\"_ _2b2\"> </span>3,866<span class=\"_ _25\"></span>,000 higher or lower<span class=\"_ _3\"></span>.Percentage of completion of \ufb01xed price process development revenues<span class=\"_ _2b2\"> </span>As it satis\ufb01es its performance obligations the Group recognises revenue and the r<span class=\"_ _25\"></span>elated contract asset with regard to \ufb01xed price process<span class=\"_ _2b2\"> </span>development work packages. Revenues are recognised on a percentage of completion basis and as such r<span class=\"_ _25\"></span>equire estimation in terms of<span class=\"_ _2b2\"> </span>the assessment of the correct percentage of completion for that speci\ufb01c pr<span class=\"_ _25\"></span>ocess development work package. The value of the revenue<span class=\"_ _2b2\"> </span>recognised raised with regard to the work packages which remain in pr<span class=\"_ _25\"></span>ogress at year end is \u00a38,179<span class=\"_ _3\"></span>,000. If the assessed percentage<span class=\"ls1\"> </span>of completion was 10 percentage points higher or lower<span class=\"_ _25\"></span>, revenue recognised in the period would have been \u00a3818<span class=\"_ _25\"></span>,000 higher or lower<span class=\"_ _3\"></span>.<span class=\"_ _2b2\"> </span>Provision for out of speci\ufb01cation bioprocessing batches<span class=\"_ _2b2\"> </span>Bioprocessing of clinical/commercial product for clients is r<span class=\"_ _25\"></span>ecognised on a percentage of completion basis over time as the processes<span class=\"_ _2b2\"> </span>are carried out. Progress is determined based on the achievement of veri\ufb01able stages of the pr<span class=\"_ _25\"></span>ocess.<span class=\"_ _2b2\"> </span>As Oxford Biomedica (UK) Ltd has now been bioprocessing product acr<span class=\"_ _25\"></span>oss a number of years, and also in a commercial capacity<span class=\"_ _25\"></span>, <span class=\"ls1\"> </span>Oxford Biomedica (UK) Ltd has assessed the need to include an estimate of bioprocessed pr<span class=\"_ _25\"></span>oduct for which revenue has previously been<span class=\"_ _2b2\"> </span>recognised and which may be reversed should the product go out of speci\ufb01cation during the r<span class=\"_ _25\"></span>emaining period over which the product<span class=\"ls1\"> </span>is bioprocessed. In calculating this estimate Oxford Biomedica (UK) Ltd has look<span class=\"_ _25\"></span>ed at historical rates of out of speci\ufb01cation batches across<span class=\"_ _2b2\"> </span>the last four years, and has applied the percentage of out of speci\ufb01cation batches to total batches pr<span class=\"_ _25\"></span>oduced across the assessed period to<span class=\"_ _2b2\"> </span>the revenue recognised on batches which have not yet completed the bioprocessing pr<span class=\"_ _25\"></span>ocess at year end. This estimate, based on<span class=\"ls1\"> </span>the historical percentage, may be signi\ufb01cantly higher or lower depending on the number of bioprocessing batches actually going out<span class=\"ls1\"> </span>of speci\ufb01cation in future. If the historical percentage had been 10% higher or lower<span class=\"_ _3\"></span>, the estimate would be \u00a3259,<span class=\"_ _25\"></span>000 higher or lower<span class=\"_ _25\"></span>.<span class=\"ls1\"> </span>The estimate will increase or decrease based on the number of bioprocessing batches undertak<span class=\"_ _25\"></span>en, the percentage of completion<span class=\"ls1\"> </span>of those bioprocessing batches, and the number of batches which go out of speci\ufb01cation over the assessment period.<span class=\"_ _2b2\"> </span>Consequently, biopr<span class=\"_ _25\"></span>ocessing revenue of \u00a32,592,000 (2021: \u00a3769<span class=\"_ _3\"></span>,000) has not been recognised during 2022, with the corresponding<span class=\"_ _2b2\"> </span>credit to contract liabilities (note 19). This revenue will be recognised as the batches complete bioprocessing.<span class=\"_ _2b2\"> </span>No provision for out of speci\ufb01cation batches has been raised for Oxfor<span class=\"_ _25\"></span>d Biomedica Solutions as management has concluded that,<span class=\"_ _2b2\"> </span>based on review of analytical testing results received after year end, no biopr<span class=\"_ _25\"></span>ocessing batch was deemed to be at risk of failure to meet<span class=\"_ _2b2\"> </span>speci\ufb01cations.<span class=\"_ _2b2\"> </span>Amortisation of intangibles assets (developed technology)<span class=\"_ _2b2\"> </span>The estimated useful life of developed technology acquired by the Group is 15 years as the Group expects the technology to genera<span class=\"_ _25\"></span>te<span class=\"_ _2b2\"> </span>cash \ufb02ows for a total of 15 years. The estimate of 15 years is based on management\u2019s experience of the time period over which the<span class=\"_ _2b2\"> </span>technology acquired as part of the acquisition of Oxford Biomedica Solutions will become fully obsolete. Over time as the platform<span class=\"_ _2b2\"> </span>technology is improved, parts of the technology become obsolete as they are superseded by new technology until after 15 years the<span class=\"_ _2b2\"> </span>original technology is expected to have been fully replaced by newer/improved technology<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">If the estimated useful life of the assets had been 10 years, the estimated amortisation for the year ended 31 December 2022 would be<span class=\"_ _2b2\"> </span></span>\u00a33,<span class=\"_ _25\"></span>036,<span class=\"_ _25\"></span>000 higher (2021: nil); whilst, if the estimated useful life of the assets had been 20 years, the estimated amortisation for the year<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">ended 31 December 2022 would be \u00a31,518,</span><span class=\"_ _25\"></span>000 lower (2021:nil).<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs264\">Sale and leaseback \u2013 Lease liability discount rate<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs265\">During November 2022 the Group sold its Windrush Court facility property to Kadans for a cash consideration of \u00a360 million in a sale and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs266\">leaseback transaction (refer note 33). A key estimate identi\ufb01ed by the Group within the sale and leaseback agr<span class=\"_ _25\"></span>eement is the incremental </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs267\">borrowing rate used to discount the lease liability cash \ufb02ows back to their present value to determine the lease liability at year end. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs268\">Since the rate implicity in the lease is not readily determinable, the Group's incremental borrowing ra<span class=\"_ _25\"></span>te has been used (the rate of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs269\">interest that would have to be paid to borrow on a collateralised basis over a similar term for an amount equal to the lease payments </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs26a\">in a similar economic environment) based on the information available at commencement date in determining the discount rate used </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs26b\">to calculate the present value of lease payments. The rates have been determined using previously available in<span class=\"_ _25\"></span>formation on borrowing </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs26c\">rates as well as indicative borrowing rates that would be available based on the value, currency and borr<span class=\"_ _25\"></span>owing term provided by \ufb01nancial </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs26d\">institutions, adjusted for company and market speci\ufb01c factors. Estimation of uncertainty is involved in selecting an appropriate ra<span class=\"_ _25\"></span>te, and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs26e\">the rate selected for each lease will have an impact on the value of the lease liability and corresponding right-of-use (ROU) asset in the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs26f\">Consolidated Statement of \ufb01nancial positions.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs270\">If the estimated lease liability discount rate had been one percentage higher or lower<span class=\"_ _25\"></span>, the gain recognised on the sale of Windrush court </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs271\">would have been \u00a31,775<span class=\"_ _25\"></span>,000 higher or lower (2021: \u00a3nil) with the other side of the entry decr<span class=\"_ _25\"></span>easing or increasing the lease liability by a </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs272\">\u00a32,027<span class=\"_ _27\"></span>,000 (2021: \u00a3nil) and decreasing and increasing right of use assets by a \u00a3253<span class=\"_ _25\"></span>,000 (2021: \u00a3nil). </div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse ws0 gs273\">Valuation of put option liability<span class=\"_ _2b2\"> </span></div><div class=\"t m10 h7 ff9 fs4 fc3 sc0 lse ws0 gs274\">Where a put option with non-controlling shareholders exists on their equity interests, a liability for the fair value o<span class=\"_ _25\"></span>f the exercise price </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs275\">of the option is recognised. On 10 March 2022, the Group recognised a put option liability to acquir<span class=\"_ _25\"></span>e the remaining 20% of Oxford </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs276\">Biomedica Solutions that it doesn\u2019t already own, from Homology Medicines. The fair value of the option at the date of acquisition was </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs277\">assessed to be \u00a339<span class=\"_ _25\"></span>.0 million. At 31 December 2022 the fair value o<span class=\"_ _25\"></span>f the put option liability was \u00a338.2 million (Dec 2021: \u00a3nil).<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs278\">The Group estimates the value of the put liability using a Monte Carlo simulation which calculates the expected future ex<span class=\"_ _25\"></span>ercise value of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs279\">the put option, taking into consideration Oxford Biomedica Solutions\u2019 forecasted revenues over the period up until the expected ex<span class=\"_ _25\"></span>ercise </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs27a\">date along with the expected volatility of those revenues over that same period. The expected future ex<span class=\"_ _25\"></span>ercise value is then discounted<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs27b\">to the present using a discount rate in order to capture the counter party risk of the expected payment. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs27c\">Key estimation uncertainty inputs which directly impact the valuation of the put option liability are assessed to be:</div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs27d\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _2e\"> </span><span class=\"ls11\">Revenues of Oxfor<span class=\"_ _25\"></span><span class=\"_ _2b2\">d Biomedica Solutions \u2013\u2009the revenues of Oxford Biomedica Solutions are based on the management approved f</span><span class=\"_ _25\"></span>orecast </span></div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 ls11 ws0 gs27e\">up until the end of the option period. Should the forecast change or the actual results vary this may impact the value of the put option </div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 ls11 ws70 gs27f\">liability. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs280\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Expected volatility of revenues \u2013 should the expected volatility of Oxford Biomedica Solutions r<span class=\"_ _25\"></span>evenues vary, this may impact the value </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs281\">of the put option liability,</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs282\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Discount rate \u2013 the discount rate may be impacted by economic and market factors, as well as changes to the risk free rate of r<span class=\"_ _25\"></span>eturn </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs283\">which impacts debt borrowing rates. Should the discount rate calculated by management be adjusted, this may impact the value of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs284\">the put option. Management has calculated the discount rate based on the risk free rate, the expected return from similar companies </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs285\">and the Group\u2019s cost of debt.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs286\">Fair value<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs287\">Put option liability <span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs288\">31 December 2022</div><div class=\"t m1 h9 ffa fs0 fc3 sc0 ls1 ws0 gs289\"> <span class=\"_ _5b\"> </span><span class=\"fs5\"> <span class=\"_ _5b\"> </span><span class=\"ff9\"> <span class=\"_ _1b5\"> </span><span class=\"lsa wsa\">Increase<span class=\"_ _159\"> </span>Decrease<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs28a\"><span class=\"_ _2b2\">Effect in thousands of pounds:<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs28b\">Revenues of Oxford Biomedica Solutions:<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs28c\">10% higher or lower<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs28d\">2.1<span class=\"_ _75\"> </span>(2.<span class=\"_ _3\"></span>4)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs28e\">Discount rate 2% lower or higher<span class=\"_ _1a6\"> </span><span class=\"fs5 ls3c ws33\">1<span class=\"_ _2\"></span>.4<span class=\"_ _72\"> </span><span class=\"lsa wsa\">(1.<span class=\"_ _3\"></span>4)<span class=\"_ _2b2\"> </span></span></span></div>Valuation of acquired intangible assets<span class=\"_ _2b2\"> </span>As part of the acquisition accounting for the acquisition of Oxford Biomedica Solutions LL<span class=\"_ _25\"></span>C in 2022, we have performed an assessment<span class=\"_ _2b2\"> </span>on the identi\ufb01cation, fair value, and expected useful economic lives of acquired intangible assets such as developed technology assets<span class=\"_ _2b2\"> </span>at the date of acquisition. The fair value attributed to intangible assets arising on acquisition is recognised in accordance with IAS 38<span class=\"_ _2b2\"> </span>Intangible assets and is based on a number of estimates.<span class=\"_ _2b2\"> </span>The acquired identi\ufb01able assets and liabilities have been recognised at their fair values at acquisition date and in accordance with the<span class=\"_ _2b2\"> </span>Group\u2019s accounting policies. The fair value of the developed technologies intangible asset is considered a key estimate subject to<span class=\"_ _2b2\"> </span>estimation uncertainty. Below ar<span class=\"_ _25\"></span>e the details for the valuation methodologies used for the intangible assets.<span class=\"_ _2b2\"> </span>Acquired developed technology has been valued using the multi-period excess earnings method (MPEEM) method, valued at <span class=\"ls1\"> </span>\u00a3102.8 million, The MPEEM method considers the present value of net cash \ufb02ows expected to be generated by the client r<span class=\"_ _25\"></span>elationships, <span class=\"ls1\"> </span>by excluding any cash \ufb02ows related to contributory assets.<span class=\"_ _2b2\"> </span>Management considers the weighted average return on assets and discount rates as critical estimates as a reasonably possible change<span class=\"_ _2b2\"> </span>to these assumptions in aggregation, or in isolation, will have an impact on the consolidated \ufb01nancial statements. The weighted average<span class=\"_ _2b2\"> </span>return on assets and discount rate used by management in the valuation of the developed technology is 17<span class=\"_ _27\"></span>.3% and 20% respectively.<span class=\"_ _2b2\"> </span>Below are the various sensitivities of weighted average return on assets and discount rates and their impact on the rela<span class=\"_ _25\"></span>ted <span class=\"ls1\"> </span>intangible assets.<span class=\"_ _2b2\"> </span>Sensitivities<span class=\"_ _2b2\"> </span>Discount rate<span class=\"_ _2b2\"> </span>Weighted average <span class=\"_ _1e\"></span><span class=\"ls1\"> </span>rate of return<span class=\"_ _2b2\"> </span>Adjusted Developed<span class=\"ls1\"> </span>technology value<span class=\"ls1\"> </span>\u00a3\u2019m<span class=\"_ _2b2\"> </span>Impact<span class=\"ls1 ws0\"> </span>\u00a3\u2019m<span class=\"_ _2b2\"> </span>17%<span class=\"_ _1d9\"> </span><span class=\"ffa\">15.0%<span class=\"_ _16f\"> </span>121.8<span class=\"_ _1da\"> </span><span class=\"ls42 ws3a\">19.<span class=\"_ _2\"></span>0<span class=\"_ _2b2\"> </span></span></span>18%<span class=\"_ _1db\"> </span><span class=\"ffa ls2 ws3\">15.8%<span class=\"_ _78\"> </span></span><span class=\"ffa\">113.5<span class=\"_ _12\"> </span><span class=\"ls3d ws34\">10.7<span class=\"_ _2b2\"> </span></span></span>19%<span class=\"_ _1db\"> </span><span class=\"ffa\">16.5%<span class=\"_ _f4\"> </span>106.0<span class=\"_ _67\"> </span><span class=\"ls43 ws3b\">3.<span class=\"_ _2\"></span>2<span class=\"_ _2b2\"> </span></span></span>3, Financial risk management<span class=\"_ _2b2\"> </span>Financial risk factors<span class=\"_ _2b2\"> </span>The Group has a simple corporate structure which consists of the Company and two main operating subsidiaries, one domiciled in<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">the UK and the other in the US. Monitoring of \ufb01nancial risk is part of the Board\u2019s ongoing risk management, the effectiveness of which<span class=\"_ _2b2\"> </span></span>is reviewed annually<span class=\"_ _25\"></span><span class=\"_ _2b2\">. The Group\u2019s agreed policies are implemented by the Chief Financial Officer</span><span class=\"_ _25\"></span>, who submits reports at each Board<span class=\"_ _2b2\"> </span>meeting. The Group does not use \ufb01nancial derivatives, and it is the Group\u2019s policy not to undertake any trading in \ufb01nancial instruments.<span class=\"_ _2b2\"> </span>(a) Foreign exchange risk<span class=\"_ _2b2\"> </span>In 2022 the Group\u2019s revenues were mostly receivable in Sterling and US Dollars, and certain o<span class=\"_ _25\"></span>f its expenditures were payable in Euros<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">and US Dollars. The majority of the UK based entities\u2019 operating costs are denominated in Sterling. A 10% difference in the \u00a3/$ a</span><span class=\"_ _25\"></span>verage<span class=\"_ _2b2\"> </span>exchange rate would have had an impact of approxima<span class=\"_ _25\"></span>tely \u00a31,121,000 (2021: \u00a3712,<span class=\"_ _25\"></span>000) over the year<span class=\"_ _25\"></span>. The US based entities\u2019 revenue<span class=\"ls1\"> </span>and operating costs are all in USD<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>The Group also has exposure to the \u00a3/$ exchange rate due to the Oaktree loan facility denomina<span class=\"_ _25\"></span>ted in Dollars. Had the \u00a3/$ exchange rate<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">been 10% different, the impact on cost in 2022 would have been approximately \u00a3455</span><span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>000 (2021: nil).<span class=\"_ _2b2\"> </span>The Group also has exposure to the \u00a3/\u20ac exchange rate due to the need to fund certain expenditure denomina<span class=\"_ _25\"></span>ted in Euros. Had the average<span class=\"_ _2b2\">\u00a3/\u20ac exchange rate been 10% different, the impact on cost in 2022 would have been appro</span><span class=\"_ _25\"></span>ximately \u00a3418,<span class=\"_ _25\"></span>000 (2021: \u00a3305,<span class=\"_ _25\"></span>000). TheGroup\u2019s policy is to hold the majority of its funds in Sterling and US Dollars. No other hedging of foreign curr<span class=\"_ _25\"></span>ency cash \ufb02ows is undertaken.(b) Interest rate risk<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The Group\u2019s policy is to maximise interest receivable on deposits, subject to maintaining access to sufficient liquid funds to meet day</span><span class=\"ls1\"> </span>to day operational requirements and preserving the security of invested funds. With the curr<span class=\"_ _25\"></span>ent low level of bank interest rates at the start<span class=\"_ _2b2\"> </span>of the year<span class=\"_ _25\"></span>, interest receivable on bank deposits in 2022 was just \u00a3973<span class=\"_ _25\"></span>,000 (2021: \u00a3nil).<span class=\"_ _2b2\"> </span>On 10 March 2022, the Group drew down an US$85 million loan facility with Oaktree to \ufb01nance the acquisition of Oxf<span class=\"_ _25\"></span>ord Biomedica<span class=\"_ _2b2\"> </span>Solutions, under a 1 year facility agreement maturing in 2023. On 7 October 2022, the loan facility was re\ufb01nanced with Oaktr<span class=\"_ _25\"></span>ee. Under<span class=\"_ _2b2\"> </span>the terms of such re\ufb01nancing, the Company has partially repaid the outstanding amounts under the Short-<span class=\"_ _3\"></span>T<span class=\"_ _27\"></span>erm Loan Facility and<span class=\"_ _2b2\"> </span>amended the facility into a new senior secured four year term loan facility provided by Oaktree in a principal amount of US$50 million.<span class=\"_ _2b2\"> </span>The T<span class=\"_ _27\"></span>erm Loan carries a variable interest rate, which is capped at 10.25% per annum and payable quarterly in cash, with up to 50% of<span class=\"_ _2b2\"> </span>interest for the \ufb01rst twelve months payable in kind as additional loan principal, at the option of the Company<span class=\"_ _25\"></span>. The interest rate is subject<span class=\"ls1\"> </span>to downward adjustment following the satisfaction of certain commercial conditions.<span class=\"_ _2b2\"> </span>If interest rates had been 1% higher in 2022 the impact on cash interest paid would have been \u00a3nil (2022: \u00a3nil).<span class=\"_ _2b2\"> </span>(c) Credit risks<span class=\"_ _2b2\"> </span>Cash balances are mainly held on short term deposits with \ufb01nancial institutions with a credit rating of at least A, in line with the Group\u2019s<span class=\"_ _2b2\"> </span>policy to minimise the risk of loss.<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>rade debtors are monitored to minimise the risk of loss (note 16).<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs2ce\">Derivative \ufb01nancial instruments and hedging<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2cf\"><span class=\"_ _2b2\">There were no material derivatives at 31 December 2022 or 31 December 2021 which have r</span><span class=\"_ _25\"></span>equired separation, and hedge accounting </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2d0\">has not been used.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs2d1\">Fair value estimates<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2d2\">The fair value of short term deposits with a maturity of one year or less is assumed to be the book value.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs2d3\">Capital Management<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2d4\">The Group\u2019s objectives when managing capital are to safeguard the Group\u2019s ability to continue as a going concern in or<span class=\"_ _25\"></span>der to provide </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2d5\">returns to shareholders and bene\ufb01ts for other stakeholders, and to maintain an optimal capital structur<span class=\"_ _25\"></span>e to minimise the cost of capital.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2d6\">Group<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fc3 sc0 lse wsd gs2d7\">2022<span class=\"fs5 ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2d8\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs2d9\">2021 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs2da\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs2db\"><span class=\"_ _2b2\">Net (cash)/debt\u2009\u00b2</span><span class=\"_ _1dc\"> </span><span class=\"ffa wsa\">(101,505)<span class=\"_ _3d\"> </span><span class=\"ff9\"><span class=\"_ _2b2\">(108,944)\u2009\u00b9<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs2dc\">Equity<span class=\"_ _1dd\"> </span><span class=\"ffa\">236,192<span class=\"_ _109\"> </span></span>187<span class=\"_ _3\"></span>,338<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2dd\">Debt/equity<span class=\"_ _1de\"> </span>43%<span class=\"_ _8d\"> </span><span class=\"ff9\">(58%)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs2de\">\u00b9 <span class=\"_ _5d\"> </span> <span class=\"_ _1e\"></span>Represents Cash balance only as no debt.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs2df\">\u00b2 <span class=\"_ _5d\"> </span>Net (cash)/debt is Cash and cash equivalents less Loans as outlined on page 136.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs2e0\">4, Segmental analysis Segmental reporting<span class=\"_ _2b2\"> </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs2e1\">The chief operating decision-maker has been identi\ufb01ed as the Senior Executive T<span class=\"_ _27\"></span>eam (SET), comprising the Executive Directors, Chief </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs2e2\"><span class=\"_ _2b2\">Commercial Officer</span><span class=\"_ _25\"></span>, Chief T<span class=\"_ _27\"></span><span class=\"_ _2b2\">echnical Officer, Chief Scienti\ufb01c Officer</span><span class=\"_ _3\"></span><span class=\"_ _2b2\">, Chief Business and Corporate Development Officer, Chief Operations </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs2e3\"><span class=\"_ _2b2\">Officer</span><span class=\"_ _25\"></span><span class=\"_ _2b2\">, Chief People Officer</span><span class=\"_ _25\"></span><span class=\"_ _2b2\">, Chief Information Officer and General Counsel. The SET monitors the performance of the Group in two </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs2e4\">business segments:</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2e5\">(i)  <span class=\"_ _32\"></span>Platform \u2013 this segment consists of the revenue generating bioprocessing and pr<span class=\"_ _25\"></span>ocess development activities undertaken for third </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2e6\">parties (i.e the partner programmes LentiV<span class=\"_ _25\"></span>ector<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h14 ff9 fs7 fc3 sc0 ls1 ws0 gs2e7\">\u00ae</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2e8\"> and AA<span class=\"_ _25\"></span>V CDMOs business). It also includes internal technology developments and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2e9\">technical intellectual property within the LentiV<span class=\"_ _25\"></span>ector</div><div class=\"t m1 h14 ff9 fs7 fc3 sc0 ls1 ws0 gs2ea\">\u00ae</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2eb\"> platform.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2ec\">(ii)  <span class=\"_ _32\"></span>Product \u2013 this segment consists of the clinical and pre-clinical development of <span class=\"ffd\">in vivo</span> and <span class=\"ffd\">ex vivo</span> cell and gene therapy products </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2ed\">(gene therapeutics) which are owned by the Group.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2ee\">In the \ufb01rst quarter of 2023, the SET has re-<span class=\"_ _25\"></span>assessed the reporting segments to re\ufb02ect the way the business will be managed in future. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2ef\">Management reporting is currently being reworked to align with these new segments going f<span class=\"_ _25\"></span>orward and the Group expects to be<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2f0\">able to report on these new segments during 2023 and thereafter<span class=\"_ _3\"></span>. No changes from the current basis have been re\ufb02ected in the 2022 </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2f1\">Annual report and accounts. </div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs2f2\">Revenues, other operating income and operating loss by segment<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2f3\">Revenues, Operating EBITDA and Operating pro\ufb01t/(loss) repr<span class=\"_ _25\"></span>esent the Group\u2019s measures of segment pro\ufb01t and loss as they are a primary </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs2f4\">measure used for the purpose of making decisions about allocating resources and assessing perf<span class=\"_ _25\"></span>ormance of segments.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2f5\">2022<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2f6\">Platform <span class=\"_ _1e\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2f7\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2f8\">Product <span class=\"_ _1e\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2f9\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2fa\">T<span class=\"_ _3\"></span>otal <span class=\"_ _1e\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs2fb\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs2fc\">Revenue<span class=\"_ _1df\"> </span><span class=\"ffa\">139,<span class=\"_ _25\"></span>903<span class=\"_ _76\"> </span>86<span class=\"_ _1e0\"> </span>139,<span class=\"_ _25\"></span>989<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs2fd\">Other operating income<span class=\"_ _1e1\"> </span><span class=\"ffa wsa\">2,307<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _da\"> </span></span>2,307<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs2fe\">Gain on sale and leaseback<span class=\"_ _1e2\"> </span><span class=\"ffa wsa\">21,389 <span class=\"_ _fb\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _12b\"> </span></span>21,389<span class=\"_ _2\"></span> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs2ff\">Operating EBITDA\u00b9<span class=\"_ _1e3\"> </span><span class=\"ffa wsa\">11,654<span class=\"_ _1e0\"> </span>(10<span class=\"_ _25\"></span>,023)<span class=\"_ _8d\"> </span>1,631<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs300\">Depreciation, amortisation and share based payment<span class=\"_ _b8\"> </span><span class=\"ffa wsa\">(29,551)<span class=\"_ _15a\"> </span>(2,250)<span class=\"_ _cf\"> </span>(31,801)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs301\">Operating loss<span class=\"_ _1e4\"> </span><span class=\"ffa wsa\">(17<span class=\"_ _3\"></span>,948)<span class=\"_ _b9\"> </span>(12,272)<span class=\"_ _d0\"> </span>(30<span class=\"_ _25\"></span>,220)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs302\">Net \ufb01nance cost<span class=\"_ _1e5\"> </span><span class=\"ffa wsa\">(15,756)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs303\">Loss before tax<span class=\"_ _1e6\"> </span><span class=\"ffa wsa\">(45,976)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs304\">2021<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs305\">Platform <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs306\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs307\">Product <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs308\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs309\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span> <span class=\"_ _2f\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs30a\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs30b\">Revenue<span class=\"_ _1e7\"> </span>142,<span class=\"_ _25\"></span>693<span class=\"_ _82\"> </span>104<span class=\"_ _109\"> </span>142,<span class=\"_ _25\"></span>797<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs30c\">Other operating income<span class=\"_ _1e8\"> </span><span class=\"wsa\">867<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _72\"> </span></span><span class=\"wsa\">867<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs30d\">Operating EBITDA\u00b9<span class=\"_ _1e9\"> </span><span class=\"wsa\">45,292<span class=\"_ _15b\"> </span>(9,368)<span class=\"_ _e3\"> </span>35,92<span class=\"_ _25\"></span>4<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs30e\">Depreciation, amortisation and share based payment<span class=\"_ _173\"> </span><span class=\"wsa\">(13,702)<span class=\"_ _15e\"> </span>(1,288)<span class=\"_ _1b5\"> </span>(14,<span class=\"_ _25\"></span>990)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs30f\">Revaluation of investments<span class=\"_ _1ea\"> </span><span class=\"wsa\">(165)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _53\"> </span></span><span class=\"wsa\">(165)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs310\">Operating pro\ufb01t/(loss)<span class=\"_ _1eb\"> </span><span class=\"wsa\">31,<span class=\"_ _3\"></span>425<span class=\"_ _109\"> </span>(10,<span class=\"_ _25\"></span>657)<span class=\"_ _15b\"> </span>20,768<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs311\">Net \ufb01nance cost<span class=\"_ _1ec\"> </span><span class=\"wsa\">(888)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs312\">Pro\ufb01t before tax<span class=\"_ _1ed\"> </span><span class=\"wsa\">19<span class=\"_ _25\"></span>,880<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs313\">\u00b9 <span class=\"_ _5d\"> </span> <span class=\"_ _1e\"></span>Operating EBITDA (Earnings Before Interest, T<span class=\"_ _3\"></span>ax, Depreciation, Amortisation, revaluation of investments and Assets at fair value through pr<span class=\"_ _25\"></span>o\ufb01t and loss, and Share Based </div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs314\">Payments) is a non-GAAP measure often used as a surrogate for operational cash \ufb02ow as it ex<span class=\"_ _25\"></span>cludes from operating pro\ufb01t or loss all non-cash items, including the </div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs315\">charge for share based payments options. A reconciliation to GAAP measures is provided on page 34<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div><span class=\"_ _2b2\">Other operating income of \u00a32.3 million (2021: \u00a30</span><span class=\"_ _25\"></span><span class=\"_ _2b2\">.9 million) includes sub lease rental income of \u00a31.</span><span class=\"_ _3\"></span>4 million (2021: Nil) in relation to a<span class=\"_ _2b2\"> </span>portion of the Patriot\u2019s Park property in the US accounted for as a as a short term lease, and grant income to further develop our supply<span class=\"_ _2b2\"> </span>chain capabilities of \u00a30.<span class=\"_ _25\"></span><span class=\"_ _2b2\">9 million (2021: \u00a30.</span><span class=\"_ _25\"></span><span class=\"_ _2b2\">9 million) and is included within the Platform segment.<span class=\"_ _2b2\"> </span></span>Costs are allocated to the segments on a speci\ufb01c basis as far as possible. Costs which cannot readily be allocated speci\ufb01cally are<span class=\"_ _2b2\"> </span>apportioned between the segments using relevant metrics such as headcount or direct costs.<span class=\"_ _2b2\"> </span>No intangible assets or \ufb01xed assets of any signi\ufb01cant value have been assessed to be assigned speci\ufb01cally to the Products division, and<span class=\"_ _2b2\"> </span>therefore no impairment has been required as a r<span class=\"_ _25\"></span>esult of the decision by the Group to look for alternative funding for the Product division.<span class=\"_ _2b2\"> </span>A segmental or geographical split of assets and liabilities is not provided because this information is not received or r<span class=\"_ _25\"></span>eviewed by the chief<span class=\"_ _2b2\"> </span>operating decision-maker<span class=\"_ _25\"></span>. All assets are located within the United Kingdom and United States.<span class=\"_ _2b2\"> </span>Disaggregation of revenue<span class=\"_ _2b2\"> </span>Revenue is disaggregated by the type of revenue which is generated by the commercial arrangement.<span class=\"_ _2b2\"> </span>2022<span class=\"_ _2b2\"> </span>Platform <span class=\"_ _1e\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Product <span class=\"_ _1e\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _3\"></span>otal <span class=\"_ _1e\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Bioprocessing/Commercial development<span class=\"_ _1ee\"> </span><span class=\"ffa wsa\">127<span class=\"_ _3\"></span>,994<span class=\"_ _76\"> </span>86<span class=\"_ _d0\"> </span>128,080<span class=\"_ _2b2\"> </span></span>Licence fees, milestones and royalties<span class=\"_ _1ef\"> </span><span class=\"ffa wsa\">11,909<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _15b\"> </span></span>11,909<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _3\"></span>otal<span class=\"_ _1a3\"> </span>139<span class=\"_ _25\"></span>,903<span class=\"_ _9a\"> </span>86<span class=\"_ _1e0\"> </span>139,989<span class=\"_ _2b2\"> </span>2021<span class=\"_ _2b2\"> </span>Platform <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Product <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span> \u00a3\u2019000<span class=\"_ _2b2\"> </span>Bioprocessing/Commercial development<span class=\"_ _a2\"> </span><span class=\"wsa\">128,318<span class=\"_ _82\"> </span>104<span class=\"_ _ee\"> </span>128,<span class=\"_ _3\"></span>422<span class=\"_ _2b2\"> </span></span>Licence fees, milestones and royalties<span class=\"_ _1f0\"> </span><span class=\"wsa\">14<span class=\"_ _25\"></span>,375<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _8c\"> </span></span>14,375<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _27\"></span>otal<span class=\"_ _1f1\"> </span>142,<span class=\"_ _25\"></span>693<span class=\"_ _82\"> </span>104<span class=\"_ _109\"> </span>142,<span class=\"_ _25\"></span>797<span class=\"_ _2b2\"> </span>Timing of transfer of goods or services<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Products and services transferred at a point of time<span class=\"_ _15f\"> </span><span class=\"ffa wsa\">11,909<span class=\"_ _8c\"> </span><span class=\"ff9\">13<span class=\"_ _25\"></span>,997<span class=\"_ _2b2\"> </span></span></span>Products and services transferred over time<span class=\"_ _e5\"> </span><span class=\"ffa wsa\">128,080<span class=\"_ _cf\"> </span><span class=\"ff9\">128,800<span class=\"_ _2b2\"> </span></span></span>T<span class=\"_ _3\"></span>otal revenue<span class=\"_ _1f2\"> </span><span class=\"wsa\">139,<span class=\"_ _25\"></span>989<span class=\"_ _109\"> </span><span class=\"ff9\">142,797<span class=\"_ _2b2\"> </span></span></span>The majority of the Group\u2019s revenue is typically recognised over time as the performance obligations in the contract ar<span class=\"_ _25\"></span>e being ful\ufb01lled.<span class=\"_ _2b2\"> </span>Results by geographical location<span class=\"_ _2b2\"> </span>The Group\u2019s revenue derives wholly from assets located in the United Kingdom and the United States. Analysed by loca<span class=\"_ _25\"></span>tion the Group\u2019s<span class=\"_ _2b2\"> </span>revenues derive predominantly from United Kingdom, United States, Eur<span class=\"_ _25\"></span>ope and the rest of the world:<span class=\"_ _2b2\"> </span>Revenue by client location<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>United Kingdom<span class=\"_ _1f3\"> </span><span class=\"ffa wsa\">49,<span class=\"_ _25\"></span>939<span class=\"_ _15e\"> </span><span class=\"ff9\">97<span class=\"_ _3\"></span>,063<span class=\"_ _2b2\"> </span></span></span>United States<span class=\"_ _1f4\"> </span><span class=\"ffa wsa\">61,591<span class=\"_ _e3\"> </span><span class=\"ff9\">20,816<span class=\"_ _2b2\"> </span></span></span>Europe<span class=\"_ _1dd\"> </span><span class=\"ffa\">28,<span class=\"_ _25\"></span>063<span class=\"_ _8c\"> </span><span class=\"ff9\">21,<span class=\"_ _25\"></span>632<span class=\"_ _2b2\"> </span></span></span>Rest of world<span class=\"_ _1f5\"> </span><span class=\"ffa wsa\">396<span class=\"_ _7c\"> </span><span class=\"ff9\">3,286<span class=\"_ _2b2\"> </span></span></span>T<span class=\"_ _3\"></span>otal revenue<span class=\"_ _1f2\"> </span><span class=\"wsa\">139,<span class=\"_ _25\"></span>989<span class=\"_ _109\"> </span><span class=\"ff9\">142,797<span class=\"_ _2b2\"> </span></span></span>In 2022 \ufb01ve clients each provided 10% or more of the Group\u2019s revenues in the pla<span class=\"_ _25\"></span>tform segment.<span class=\"_ _2b2\"> </span>Geographic split of operating loss<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>United Kingdom<span class=\"_ _1d7\"> </span><span class=\"ffa wsa\">(1,465)<span class=\"_ _cf\"> </span><span class=\"ff9\">(20,768)<span class=\"_ _2b2\"> </span></span></span>United States<span class=\"_ _1f6\"> </span><span class=\"ffa wsa\">(28,755)<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _3\"></span>otal operating loss<span class=\"_ _1f7\"> </span><span class=\"wsa\">(30,220)<span class=\"_ _cf\"> </span><span class=\"ff9\">(20,768)<span class=\"_ _2b2\"> </span></span></span>Geographic split of non current assets<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>United Kingdom<span class=\"_ _1f3\"> </span><span class=\"ffa wsa\">94,997<span class=\"_ _15e\"> </span><span class=\"ff9\">73,385<span class=\"_ _2b2\"> </span></span></span>United States<span class=\"_ _1f6\"> </span><span class=\"ffa wsa\">149,<span class=\"_ _25\"></span>679<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span>T<span class=\"_ _3\"></span>otal non current assets<span class=\"_ _147\"> </span><span class=\"wsa\">244,676<span class=\"_ _15e\"> </span><span class=\"ff9\">73,385<span class=\"_ _2b2\"> </span></span></span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs35e\">5, Employees and directors<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs35f\">The monthly average number of persons (including Executive Directors) employed by the Group during the year was:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs360\">By activity<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs361\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs362\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs363\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs364\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs365\"><span class=\"_ _2b2\">Office and management</span><span class=\"_ _1f8\"> </span><span class=\"ffa wsa\">117<span class=\"_ _91\"> </span><span class=\"ff9\">56<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs366\">Research, development and bioprocessing<span class=\"_ _1f9\"> </span><span class=\"ffa wsa\">812<span class=\"_ _72\"> </span><span class=\"ff9\">703<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs367\">T<span class=\"_ _3\"></span>otal<span class=\"_ _1fa\"> </span>929<span class=\"_ _82\"> </span><span class=\"ff9\">759<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs368\">Employee bene\ufb01t costs<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs369\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs36a\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs36b\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs36c\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs36d\">Wages and salaries<span class=\"_ _1fb\"> </span><span class=\"ffa wsa\">70,042<span class=\"_ _8c\"> </span><span class=\"ff9\">43<span class=\"_ _25\"></span>,174<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs36e\">Social security costs<span class=\"_ _1dc\"> </span><span class=\"ffa wsa\">6,165<span class=\"_ _85\"> </span><span class=\"ff9\">5,122<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs36f\">Other pension costs (note 32)<span class=\"_ _1df\"> </span><span class=\"ffa wsa\">3,560<span class=\"_ _da\"> </span><span class=\"ff9\">2,839<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs370\">Share based payments (note 28)<span class=\"_ _1fc\"> </span><span class=\"ffa wsa\">6,471<span class=\"_ _8d\"> </span><span class=\"ff9\">3,523<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs371\">T<span class=\"_ _3\"></span>otal employee bene\ufb01t costs<span class=\"_ _1fd\"> </span><span class=\"wsa\">86,238<span class=\"_ _e3\"> </span><span class=\"ff9\">54<span class=\"_ _25\"></span>,658<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs372\">Key management compensation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs373\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs374\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs375\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs376\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs377\">Wages and salaries<span class=\"_ _1fe\"> </span><span class=\"ffa wsa\">4,486<span class=\"_ _6b\"> </span><span class=\"ff9\">3,167<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs378\">Social security costs<span class=\"_ _1ff\"> </span><span class=\"ffa wsa\">760<span class=\"_ _71\"> </span><span class=\"ff9\">893<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs379\">Other pension costs<span class=\"_ _200\"> </span><span class=\"ffa wsa\">293<span class=\"_ _72\"> </span><span class=\"ff9\">250<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs37a\">Share based payments<span class=\"_ _19c\"> </span><span class=\"ffa wsa\">2,620<span class=\"_ _8d\"> </span><span class=\"ff9\">2,075<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs37b\">T<span class=\"_ _3\"></span>otal<span class=\"_ _148\"> </span>8,159<span class=\"_ _7c\"> </span><span class=\"ff9\">6,385<span class=\"_ _2b2\"> </span></span></div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs37c\">The key management \ufb01gures above include Executive and Non-<span class=\"_ _25\"></span>Executive Directors and the other members of the SET<span class=\"_ _27\"></span>. Further information<span class=\"_ _2\"></span> </div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs37d\">about the remuneration of individual Directors, including the highest paid Director<span class=\"_ _3\"></span>, is provided in the audited part of the Directors\u2019 </div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs37e\">Remuneration Report on page 95 which forms part of these \ufb01nancial statements.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs37f\">The Company had no employees during the year (2021: zero).<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs380\">6, Finance income and costs<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs381\">Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs382\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs383\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs384\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs385\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs386\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs387\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs388\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs389\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs38a\">Finance income:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs38b\">Bank interest receivable<span class=\"_ _14a\"> </span><span class=\"fs0 ls1\"> <span class=\"_ _dc\"> </span></span><span class=\"ffa wsa\">973<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ffa\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs38c\">T<span class=\"_ _3\"></span>otal \ufb01nance income</div><div class=\"t m1 h9 ff9 fs0 fc3 sc0 ls1 ws0 gs38d\"> <span class=\"_ _84\"> </span><span class=\"ffa fs5 lsa wsa\">973<span class=\"_ _2\"></span> <span class=\"_ _e2\"> </span></span><span class=\"fs5\">\u2013<span class=\"_ _9b\"> </span><span class=\"ffa\">\u2013<span class=\"_ _7f\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs38e\">Finance costs:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs38f\">Unwinding of discount in provisions (note 20)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs390\">(66)<span class=\"_ _81\"> </span><span class=\"ff9\">(27)<span class=\"_ _71\"> </span></span>(28)<span class=\"_ _7f\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs391\">Gain on foreign exchange<span class=\"_ _17e\"> </span><span class=\"ffa fs5 lsa wsa\">(7<span class=\"_ _25\"></span>,975)<span class=\"_ _7f\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _12b\"> </span></span>(7<span class=\"_ _25\"></span>,964)<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs392\">Interest payable on loans<span class=\"_ _201\"> </span><span class=\"ffa fs5 lsa wsa\">(5,564)<span class=\"_ _9b\"> </span></span><span class=\"fs5 ls1\">\u2013<span class=\"_ _15a\"> </span><span class=\"ffa lsa wsa\">(5,564)<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs393\">Interest payable on \ufb01nance leases<span class=\"_ _8e\"> </span><span class=\"ffa wsa\">(3,124)<span class=\"_ _6c\"> </span><span class=\"ff9\">(861)<span class=\"_ _af\"> </span></span>(477)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs394\">T<span class=\"_ _3\"></span>otal \ufb01nance costs<span class=\"_ _f3\"> </span><span class=\"wsa\">(16,729)<span class=\"_ _85\"> </span><span class=\"ff9\">(888)<span class=\"_ _1e0\"> </span></span>(14,<span class=\"_ _25\"></span>033)<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs395\">Net \ufb01nance costs<span class=\"_ _1ef\"> </span><span class=\"wsa\">(15,756)<span class=\"_ _85\"> </span><span class=\"ff9\">(888)<span class=\"_ _1e0\"> </span></span>(14,<span class=\"_ _25\"></span>033)<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs396\">7<span class=\"_ _3\"></span>, Expenses by nature<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs397\">Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h2 ffa fs0 fc3 sc0 ls0 ws27 gs398\">Notes<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs399\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs39a\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs39b\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs39c\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs39d\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs39e\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs39f\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs3a0\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs3a1\">Employee bene\ufb01t costs<span class=\"_ _ad\"> </span><span class=\"fs0 ls1\">5<span class=\"_ _15a\"> </span><span class=\"ffa fs5 lsa wsa\">86,238<span class=\"_ _e3\"> </span><span class=\"ff9\">54,<span class=\"_ _25\"></span>658<span class=\"_ _71\"> </span><span class=\"ffa\">992<span class=\"_ _72\"> </span></span>823<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs3a2\">Depreciation of property<span class=\"_ _25\"></span>, plant and equipment<span class=\"_ _17b\"> </span><span class=\"fs0 ls0 ws27\">12<span class=\"_ _e3\"> </span><span class=\"ffa fs5 lsa wsa\">20,271<span class=\"_ _8c\"> </span><span class=\"ff9\">12,<span class=\"_ _3\"></span>435<span class=\"_ _72\"> </span><span class=\"ffa\">323<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs3a3\">Amortisation<span class=\"_ _202\"> </span><span class=\"fs0 ls0 ws27\">11<span class=\"_ _54\"> </span><span class=\"ffa fs5 lsa wsa\">6,088<span class=\"_ _e2\"> </span><span class=\"ff9\">21<span class=\"_ _fb\"> </span></span><span class=\"ls1 ws6d\"> \u2013<span class=\"_ _9b\"> </span><span class=\"ff9 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></span></div>Raw materials and consumables used in<span class=\"_ _2b2\"> </span>bioprocessing<span class=\"_ _2b2\"> </span>27<span class=\"_ _3\"></span>,449<span class=\"_ _e3\"> </span><span class=\"ff9\">23,<span class=\"_ _25\"></span>026<span class=\"_ _9b\"> </span><span class=\"ffa ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Operating lease payments<span class=\"_ _7d\"> </span><span class=\"ffa fs5 lsa wsa\">231<span class=\"_ _72\"> </span><span class=\"ff9\">236<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Net loss on foreign exchange<span class=\"_ _203\"> </span><span class=\"ffa fs5 lsa wsa\">(751)<span class=\"_ _133\"> </span><span class=\"ff9\">(115)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></span></span>Company employee bene\ufb01t costs include \u00a3992,000 (2021: \u00a3823<span class=\"_ _25\"></span>,000) r<span class=\"_ _25\"></span>elating to non-executive costs paid by Oxford Biomedica UK Ltd<span class=\"_ _2b2\"> </span>and recharged to the Company<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>Depreciation is charged to cost of goods, research and development, and biopr<span class=\"_ _25\"></span>ocessing costs in the statement of comprehensive<span class=\"_ _2b2\"> </span>income.<span class=\"_ _2b2\"> </span>Amortisation is charged to research and development in the statement of compr<span class=\"_ _25\"></span>ehensive income.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The operating lease payments relate to short term leases which have been accounted for under the IFRS 16 exemption.<span class=\"_ _2b2\"> </span></span>During the year the Group (including its subsidiaries) obtained services from the Group\u2019s auditors and their associates as detailed below:<span class=\"_ _2b2\"> </span>Services provided by the Group\u2019s auditors<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Fees payable for the audit of the parent company and consolidated \ufb01nancial statements<span class=\"_ _14\"> </span><span class=\"ffa wsa\">50<span class=\"_ _91\"> </span><span class=\"ff9\">50<span class=\"_ _2b2\"> </span></span></span>Fees payable for other services:<span class=\"_ _2b2\"> </span>The audit of the Company\u2019s subsidiaries<span class=\"_ _204\"> </span><span class=\"ffa wsa\">895<span class=\"_ _72\"> </span><span class=\"ff9\">350<span class=\"_ _2b2\"> </span></span></span>Additional fees relating to prior year audit<span class=\"_ _204\"> </span><span class=\"ffa wsa\">98<span class=\"_ _91\"> </span><span class=\"ff9\">70<span class=\"_ _2b2\"> </span></span></span>Review of interim results<span class=\"_ _143\"> </span><span class=\"ffa wsa\">35<span class=\"_ _91\"> </span><span class=\"ff9\">35<span class=\"_ _2b2\"> </span></span></span>T<span class=\"_ _3\"></span>otal<span class=\"_ _148\"> </span>1,078<span class=\"_ _72\"> </span><span class=\"ff9\">505<span class=\"_ _2b2\"> </span></span>8, T<span class=\"_ _27\"></span>axation<span class=\"_ _2b2\"> </span>During 2020 the Group ceased being eligible to claim a research and development tax credits under the Government\u2019s small company<span class=\"_ _2b2\"> </span>scheme, and instead in 2021 and 2022 claimed under the Large Company scheme.<span class=\"_ _2b2\"> </span>Current tax<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Corporation tax<span class=\"_ _205\"> </span><span class=\"ffa wsa\">(1,282)<span class=\"_ _10c\"> </span><span class=\"ff9\">(1,<span class=\"_ _25\"></span>427)<span class=\"_ _2b2\"> </span></span></span>(1,282)<span class=\"_ _10c\"> </span><span class=\"ff9\">(1,<span class=\"_ _25\"></span>427)<span class=\"_ _2b2\"> </span></span>Adjustments in respect of prior periods:<span class=\"_ _206\"> </span><span class=\"ffa ls1\"> <span class=\"_ _5b\"> </span><span class=\"ff9\"> </span></span>United Kingdom corporation tax research and development credit<span class=\"_ _207\"> </span><span class=\"ffa wsa\">307<span class=\"_ _72\"> </span><span class=\"ff9\">558<span class=\"_ _2b2\"> </span></span></span>Current tax<span class=\"_ _1de\"> </span><span class=\"wsa\">(975)<span class=\"_ _85\"> </span><span class=\"ff9\">(869)<span class=\"_ _2b2\"> </span></span></span>Deferred tax<span class=\"_ _208\"> </span><span class=\"ls1\"> <span class=\"_ _5b\"> </span><span class=\"ff9\"> </span></span><span class=\"_ _2b2\">Relating to the origination of timing differences</span><span class=\"_ _209\"> </span><span class=\"ffa wsa\">1,792<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Deferred tax<span class=\"_ _20a\"> </span><span class=\"wsa\">1,792<span class=\"_ _9b\"> </span></span><span class=\"ff9 ls1\">\u2013<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _3\"></span>axation credit/(charge)<span class=\"_ _20b\"> </span><span class=\"wsa\">817<span class=\"_ _85\"> </span><span class=\"ff9\">(869)<span class=\"_ _2b2\"> </span></span></span>U.K. income tax<span class=\"_ _2b2\"> </span>The amount of \u00a31,282,000 (2021:\u00a31,<span class=\"_ _27\"></span>427<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>000) included as part of the taxation charge within the statement of comprehensive income for<span class=\"_ _2b2\"> </span>the year ended 31 December 2022 comprises the corporation tax payable on the amount claimed as a Large Company T<span class=\"_ _27\"></span>ax credit (RDEC)<span class=\"_ _2b2\"> </span>within research and development expenses in the statement of comprehensive income.<span class=\"_ _2b2\"> </span>The adjustment of current tax in respect of the prior year of \u00a3307<span class=\"_ _27\"></span>,000 relates to the corporation tax credit on a lower than anticipated<span class=\"_ _2b2\"> </span>RDEC tax receipt. In 2021 the adjustment in respect of prior years in the amount of \u00a3558<span class=\"_ _25\"></span>,000 r<span class=\"_ _25\"></span>elated to a SME tax credit received relating<span class=\"_ _2b2\"> </span>to prior years.<span class=\"_ _2b2\"> </span>The United Kingdom corporation tax research and development (RDEC) credit which is included in r<span class=\"_ _25\"></span>esearch and development expenses,<span class=\"_ _2b2\"> </span>is paid in arrears once tax returns have been \ufb01led and agreed. The tax credit r<span class=\"_ _25\"></span>ecognised in the \ufb01nancial statements but not yet received is<span class=\"_ _2b2\"> </span>included in trade and other receivables in the Statement of \ufb01nancial position.<span class=\"_ _2b2\"> </span>During 2022 the Group recognised \u00a3125,<span class=\"_ _25\"></span>000 (2021: \u00a3458,<span class=\"_ _25\"></span>000) of current tax r<span class=\"_ _25\"></span>elating to tax relief obtained on exercise of share options<span class=\"_ _2b2\"> </span>directly within equity<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>The Company has no tax liability, nor is it entitled to tax cr<span class=\"_ _25\"></span>edits (2021: \u00a3nil).<span class=\"_ _2b2\"> </span>At 31 December 2022, the Group had UK tax losses, with no expiry date, to be carried forward of appro<span class=\"_ _25\"></span>ximately \u00a376.2 million (2021: \u00a378.3<span class=\"_ _2b2\"> </span>million).<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span>U.S. income tax<span class=\"_ _2b2\"> </span>Deferred tax of \u00a31,<span class=\"_ _25\"></span>764,<span class=\"_ _25\"></span><span class=\"_ _2b2\">000 (2021: Nil) relates to temporary differences r</span><span class=\"_ _25\"></span>elating to intangible assets. At 31 December 2022, the Group had US tax losses to be carried forward of appro<span class=\"_ _25\"></span>ximately \u00a37<span class=\"_ _3\"></span>.3 million (2021: \u00a3nil) that expire 20 years from it being incurred. <span class=\"_ _2b2\">Reconciliation of effective tax rate<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">The tax credit for the year is lower (2021: lower) than the standard rate of corporation tax in the UK. The differ</span><span class=\"_ _25\"></span>ences are explained below:<span class=\"_ _2b2\"> </span>Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Loss/(pro\ufb01t) on ordinary activities before tax<span class=\"_ _19\"> </span><span class=\"fs0 ls1\"> <span class=\"_ _1b5\"> </span><span class=\"ffa fs5 lsa wsa\">(45,976)<span class=\"_ _e3\"> </span><span class=\"ff9\">19<span class=\"_ _25\"></span>,880<span class=\"_ _55\"> </span><span class=\"ffa\">(4,804)<span class=\"_ _15b\"> </span></span>(2,366)<span class=\"_ _2b2\"> </span></span></span></span>Loss/(pro\ufb01t) on ordinary activities before tax multiplied by the standard rate of corporation tax in the UK of 19% (2021: 19%) <span class=\"_ _38\"> </span><span class=\"ffa fs5 lsa wsa\">8,734<span class=\"_ _10c\"> </span><span class=\"ff9\">(3,777)<span class=\"_ _82\"> </span></span>913<span class=\"_ _71\"> </span><span class=\"ff9\">450<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">Effects of:</span><span class=\"_ _a1\"> </span><span class=\"fs0 ls1\"> </span>Expenses not deductible for tax purposes<span class=\"_ _20c\"> </span><span class=\"ffa fs5 lsa wsa\">(1,985)<span class=\"_ _85\"> </span><span class=\"ff9\">(649)<span class=\"_ _71\"> </span></span>(28)<span class=\"_ _10\"> </span><span class=\"ff9\">(101)<span class=\"_ _2b2\"> </span></span></span>Income not taxable<span class=\"_ _1ab\"> </span><span class=\"ffa fs5 lsa wsa\">376<span class=\"_ _72\"> </span><span class=\"ff9\">344<span class=\"_ _8d\"> </span></span>1,272<span class=\"_ _9b\"> </span></span><span class=\"fs5 ls1\">\u2013<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _27\"></span>ransfer pricing adjustments<span class=\"_ _20d\"> </span><span class=\"ffa fs5 lsa wsa\">(1,005)<span class=\"_ _9b\"> </span></span><span class=\"fs5 ls1\">\u2013<span class=\"_ _33\"> </span><span class=\"ffa lsa wsa\">(1,005)<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span>Current tax relief less than accounting charge on share options<span class=\"_ _2b2\"> </span>(517)<span class=\"_ _10\"> </span><span class=\"ff9\">(174)<span class=\"_ _7f\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">Effects of group relief/other reliefs</span><span class=\"_ _20e\"> </span><span class=\"ffa fs5 ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _20f\"> </span></span><span class=\"lsa wsa\">(158)<span class=\"_ _af\"> </span><span class=\"ff9\">(349)<span class=\"_ _2b2\"> </span></span></span></span>Deferred tax not recognised<span class=\"_ _7d\"> </span><span class=\"ffa fs5 ls1\">\u2013<span class=\"_ _7c\"> </span><span class=\"ff9 lsa wsa\">2,829<span class=\"_ _72\"> </span><span class=\"ffa\">579<span class=\"_ _9b\"> </span></span></span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span>Amounts not recognised<span class=\"_ _210\"> </span><span class=\"ffa fs5 lsa wsa\">(4,753)<span class=\"_ _7f\"> </span></span><span class=\"fs5 ls1\">\u2013<span class=\"_ _15e\"> </span><span class=\"ffa lsa wsa\">(1,573)<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span>Rolled over gains<span class=\"_ _211\"> </span><span class=\"ffa fs5 lsa wsa\">(3,07<span class=\"_ _25\"></span>4)<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ffa\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">Effects of overseas tax rates</span><span class=\"_ _dd\"> </span><span class=\"ffa fs5 lsa wsa\">2,734<span class=\"_ _9b\"> </span></span><span class=\"fs5 ls1\">\u2013<span class=\"_ _9b\"> </span><span class=\"ffa\">\u2013<span class=\"_ _7f\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span>Adjustments in respect of prior periods<span class=\"_ _212\"> </span><span class=\"ffa wsa\">307<span class=\"_ _72\"> </span><span class=\"ff9\">558<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>T<span class=\"_ _3\"></span>otal tax (charge)/credit for the year<span class=\"_ _213\"> </span><span class=\"wsa\">817<span class=\"_ _85\"> </span><span class=\"ff9\">(869)<span class=\"_ _9b\"> </span></span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span>9<span class=\"_ _25\"></span>, Basic and diluted pro\ufb01t/(loss) per ordinar<span class=\"_ _2\"></span>y share<span class=\"_ _2b2\"> </span>The basic loss per share of 41.29p (2021: pro\ufb01t 22.<span class=\"_ _25\"></span>77p) has been calculated by dividing the (loss)/pro\ufb01t for the period by the weighted <span class=\"_ _2b2\">average number of shares in issue during the year ended 31 December 2022 being, 94</span><span class=\"_ _25\"></span>,829<span class=\"_ _25\"></span>,892 (2021: 83<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>484,173).<span class=\"_ _2b2\"> </span>As the Group made a loss this year<span class=\"_ _25\"></span><span class=\"_ _2b2\">, there is therefore no diff</span><span class=\"_ _25\"></span>erence between the basic loss per ordinary share and the diluted loss per ordinary share in the current period. The Group made a pro<span class=\"_ _25\"></span>\ufb01t in the prior period and the diluted earnings per share in the year was 22.20p, which was calculated by dividing the earnings for the period by the weighted average number of shares in issue during the period <span class=\"_ _2b2\">after adjusting for the dilutive effect of the share options outstanding at 31 December 2021 (2,134</span><span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>494).<span class=\"_ _2b2\"> </span>10, Loss for the \ufb01nancial year<span class=\"_ _2b2\"> </span>As permitted by section 408 of the Companies Act 2006, the Company\u2019s statement of comprehensive income has not been included in these \ufb01nancial statements. The Company\u2019s loss for the year was \u00a34<span class=\"_ _25\"></span>,804<span class=\"_ _25\"></span>,000 (2021: \u00a32,366<span class=\"_ _25\"></span>,000)<span class=\"_ _2b2\"> </span>.<span class=\"_ _2b2\"> </span>11, Intangible assets<span class=\"_ _2b2\"> </span>Notes<span class=\"_ _2b2\"> </span>Goodwill<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Developed technology<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Patents<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Cost<span class=\"_ _2b2\"> </span>At 1 January 2021<span class=\"_ _214\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">5,<span class=\"_ _25\"></span>636<span class=\"_ _7c\"> </span>5,636<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">At 31 December 2021</span><span class=\"_ _215\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">5,<span class=\"_ _25\"></span>636<span class=\"_ _7c\"> </span>5,636<span class=\"_ _2b2\"> </span></span>At 1 January 2022<span class=\"_ _1be\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">5,<span class=\"_ _25\"></span>636<span class=\"_ _7c\"> </span>5,636<span class=\"_ _2b2\"> </span></span>Acquisitions through business combinations<span class=\"_ _2b2\"> </span>35<span class=\"_ _82\"> </span><span class=\"fs5 lsa wsa\">610<span class=\"_ _cf\"> </span>102,869<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _de\"> </span></span>103,<span class=\"_ _25\"></span>479<span class=\"_ _2b2\"> </span></span>Retirements<span class=\"_ _216\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _15e\"> </span></span>(3,825)<span class=\"_ _e3\"> </span>(3,825)<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Effects of movements in exchange rates</span><span class=\"_ _b8\"> </span><span class=\"wsa\">51<span class=\"_ _da\"> </span>8,536<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">8,587<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">At 31 December 2022</span><span class=\"_ _1ef\"> </span><span class=\"wsa\">661<span class=\"_ _b9\"> </span>111,405<span class=\"_ _6b\"> </span>1,811<span class=\"_ _ee\"> </span>113,877<span class=\"_ _2b2\"> </span></span>Accumulated amortisation and impairment<span class=\"_ _2b2\"> </span>At 1 January 2021<span class=\"_ _214\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">5,563<span class=\"_ _7c\"> </span>5,563<span class=\"_ _2b2\"> </span></span>Charge for the year<span class=\"_ _15d\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _e2\"> </span></span><span class=\"wsa\">21<span class=\"_ _e2\"> </span>21<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">At 31 December 2021</span><span class=\"_ _215\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">5,584<span class=\"_ _7c\"> </span>5,584<span class=\"_ _2b2\"> </span></span>At 1 January 2022<span class=\"_ _1be\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">5,584<span class=\"_ _7c\"> </span>5,584<span class=\"_ _2b2\"> </span></span>Charge for the year<span class=\"_ _15d\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">6,072<span class=\"_ _89\"> </span>16<span class=\"_ _da\"> </span>6,<span class=\"_ _25\"></span>088<span class=\"_ _2b2\"> </span></span>Retirements<span class=\"_ _216\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8c\"> </span></span>(3,<span class=\"_ _25\"></span>797)<span class=\"_ _8c\"> </span>(3<span class=\"_ _25\"></span>,797)<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Effects of movements in exchange rates</span><span class=\"_ _217\"> </span><span class=\"ls1\">\u2013<span class=\"_ _dc\"> </span></span><span class=\"wsa\">116<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _84\"> </span></span><span class=\"wsa\">116<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">At 31 December 2022</span><span class=\"_ _218\"> </span><span class=\"ls1\">\u2013<span class=\"_ _da\"> </span></span><span class=\"wsa\">6,188<span class=\"_ _da\"> </span>1,803<span class=\"_ _8d\"> </span>7<span class=\"_ _25\"></span>,991<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">Net book amount at 31 December 2022</span><span class=\"_ _ad\"> </span><span class=\"wsa\">661<span class=\"_ _1b5\"> </span>105,217<span class=\"_ _13e\"> </span></span><span class=\"ls1\">8<span class=\"_ _d0\"> </span></span><span class=\"wsa\">105,886<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">Net book amount at 31 December 2021</span><span class=\"_ _219\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _89\"> </span></span><span class=\"wsa\">52<span class=\"_ _89\"> </span>52<span class=\"_ _2b2\"> </span></span>Intangible assets comprise Goodwill, Developed T<span class=\"_ _27\"></span>echnology and Patents for intellectual property rights. The Group has not capitalised<span class=\"_ _2b2\"> </span>any internally generated intangible assets.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs42c\">12, Property, plant and equipment<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs42d\">Group<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs42e\">Freehold<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs42f\">property<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs430\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs431\">Leasehold </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs432\">improvements\u00b9 </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs433\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs434\"><span class=\"_ _2b2\">Office</span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs435\">equipment<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs436\">and computers <span class=\"_ _1e\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs437\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs438\">Bioprocessing </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs439\">and Laboratory </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs43a\">equipment<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs43b\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs43c\">Right of use<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs43d\">asset<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs43e\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs43f\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs440\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs441\">Cost<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs442\">At 1 January 2022<span class=\"_ _114\"> </span><span class=\"wsa\">25,<span class=\"_ _3\"></span>409<span class=\"_ _8c\"> </span>28<span class=\"_ _25\"></span>,145<span class=\"_ _e3\"> </span>10,663<span class=\"_ _15b\"> </span>29,505<span class=\"_ _ed\"> </span>18,<span class=\"_ _3\"></span>411<span class=\"_ _10d\"> </span>112,133<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs443\">Additions at cost<span class=\"_ _bb\"> </span><span class=\"wsa\">113<span class=\"_ _af\"> </span>7<span class=\"_ _3\"></span>,767<span class=\"_ _82\"> </span>955<span class=\"_ _af\"> </span>7<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>461<span class=\"_ _160\"> </span>13,<span class=\"_ _25\"></span>038<span class=\"_ _e3\"> </span>29,334<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs444\">Reallocations<span class=\"_ _1cf\"> </span><span class=\"ls55 ws4c\">14<span class=\"_ _10\"> </span></span>(417)<span class=\"_ _89\"> </span>(6)<span class=\"_ _6f\"> </span>409<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs445\">Acquisitions through business </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs446\">combinations<span class=\"_ _9\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _8c\"> </span></span>22,<span class=\"_ _25\"></span>747<span class=\"_ _72\"> </span>788<span class=\"_ _160\"> </span>10,<span class=\"_ _3\"></span>436<span class=\"_ _15e\"> </span><span class=\"ls3f ws36\">24,<span class=\"_ _2\"></span>974<span class=\"_ _e3\"> </span></span>58,<span class=\"_ _25\"></span>945<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs447\">Disposals<span class=\"_ _21a\"> </span>(15,<span class=\"_ _25\"></span>688)<span class=\"_ _bb\"> </span>(45)<span class=\"_ _10\"> </span>(127)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _b9\"> </span></span>(15,860)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs448\">Change in estimate<span class=\"_ _a4\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _15e\"> </span></span><span class=\"wsa\">(1,349)<span class=\"_ _160\"> </span>(1,349)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs449\"><span class=\"_ _2b2\">Effects of movements</span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs44a\">in exchange rates<span class=\"_ _a6\"> </span><span class=\"ls1\">\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">1,986<span class=\"_ _91\"> </span>65<span class=\"_ _81\"> </span>912<span class=\"_ _8d\"> </span>2,072<span class=\"_ _8d\"> </span>5,<span class=\"_ _25\"></span>035<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs44b\"><span class=\"_ _2b2\">At 31 December 2022</span><span class=\"_ _16c\"> </span><span class=\"wsa\">9,848<span class=\"_ _15a\"> </span>60,228<span class=\"_ _12b\"> </span>12,420<span class=\"_ _15a\"> </span>48,596<span class=\"_ _15e\"> </span>57<span class=\"_ _25\"></span>,146<span class=\"_ _d0\"> </span>188,238<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs44c\">Accumulated depreciation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs44d\">At 1 January 2022<span class=\"_ _116\"> </span><span class=\"wsa\">12,652<span class=\"_ _7c\"> </span>6,226<span class=\"_ _da\"> </span><span class=\"ls5c ws71\">6,863<span class=\"_ _5e\"> </span></span>12,519<span class=\"_ _6b\"> </span>4,1<span class=\"_ _25\"></span>45<span class=\"_ _15b\"> </span>42,<span class=\"_ _25\"></span>405<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs44e\">Charge for the year<span class=\"_ _e9\"> </span><span class=\"wsa\">2,052<span class=\"_ _6b\"> </span>5,167<span class=\"_ _da\"> </span>2,204<span class=\"_ _6b\"> </span>5,916<span class=\"_ _7c\"> </span>4,<span class=\"_ _25\"></span>932<span class=\"_ _8c\"> </span>20<span class=\"_ _25\"></span>,271<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs44f\"><span class=\"_ _2b2\">Effects of movements</span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs450\">in exchange rates<span class=\"_ _a6\"> </span><span class=\"ls1\">\u2013<span class=\"_ _89\"> </span></span><span class=\"wsa\">47<span class=\"_ _59\"> </span></span><span class=\"ls1\">2<span class=\"_ _9a\"> </span></span><span class=\"wsa\">40<span class=\"_ _e2\"> </span>19<span class=\"_ _72\"> </span>108<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs451\">Disposals<span class=\"_ _f\"> </span>(8,210)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _82\"> </span></span>(27)<span class=\"_ _72\"> </span>(89)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _15b\"> </span></span>(8,326)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs452\"><span class=\"_ _2b2\">At 31 December 2022</span><span class=\"_ _16c\"> </span><span class=\"wsa\">6,494<span class=\"_ _15b\"> </span>11,440<span class=\"_ _d7\"> </span>9<span class=\"_ _25\"></span>,042<span class=\"_ _12b\"> </span>18,386<span class=\"_ _d7\"> </span>9<span class=\"_ _25\"></span>,096<span class=\"_ _15a\"> </span>54,458<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs453\">Net book amount<span class=\"ls1\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs454\"><span class=\"_ _2b2\">at 31 December 2022</span><span class=\"_ _175\"> </span><span class=\"wsa\">3,354<span class=\"_ _33\"> </span>48,788<span class=\"_ _da\"> </span>3,378<span class=\"_ _12b\"> </span>30,210<span class=\"_ _10d\"> </span>48,050<span class=\"_ _cf\"> </span>133,780<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs455\">Group<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs456\">Freehold<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs457\">property<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs458\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs459\">Leasehold </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs45a\">improvements </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs45b\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs45c\"><span class=\"_ _2b2\">Office</span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs45d\">equipment<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs45e\">and computers <span class=\"_ _1e\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs45f\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs460\">Bioprocessing </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs461\">and Laboratory </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs462\">equipment<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs463\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs464\">Right of use<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs465\">asset<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs466\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs467\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs468\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs469\">Cost<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs46a\">At 1 January 2021<span class=\"_ _a3\"> </span><span class=\"wsa\">23,331<span class=\"_ _10c\"> </span>27<span class=\"_ _3\"></span>,219<span class=\"_ _8d\"> </span>9,106<span class=\"_ _12b\"> </span><span class=\"ls3f ws36\">24,6<span class=\"_ _2\"></span>06<span class=\"_ _10c\"> </span></span>18,<span class=\"_ _25\"></span>012<span class=\"_ _de\"> </span>102,274<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs46b\">Additions at cost<span class=\"_ _21b\"> </span><span class=\"wsa\">2,078<span class=\"_ _71\"> </span>939<span class=\"_ _af\"> </span>1,557<span class=\"_ _da\"> </span>4,<span class=\"_ _25\"></span>886<span class=\"_ _e2\"> </span>21<span class=\"_ _6b\"> </span>9<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>481<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs46c\">Reclassi\ufb01cation<span class=\"_ _21c\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _81\"> </span></span>(13)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _e2\"> </span></span>13<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs46d\">Disposals<span class=\"_ _21d\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _72\"> </span></span>378<span class=\"_ _82\"> </span>378<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs46e\"><span class=\"_ _2b2\">At 31 December 2021</span><span class=\"_ _128\"> </span><span class=\"wsa\">25,<span class=\"_ _25\"></span>409<span class=\"_ _15b\"> </span>28,145<span class=\"_ _12b\"> </span>10,663<span class=\"_ _12b\"> </span>29,505<span class=\"_ _15e\"> </span>18,411<span class=\"_ _ee\"> </span>112,133<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs46f\">Accumulated depreciation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs470\">At 1 January 2021<span class=\"_ _d\"> </span><span class=\"wsa\">10,<span class=\"_ _3\"></span>444<span class=\"_ _6b\"> </span>3,519<span class=\"_ _8d\"> </span><span class=\"ls3f ws36\">4,6<span class=\"_ _2\"></span>10<span class=\"_ _6c\"> </span></span>9<span class=\"_ _25\"></span>,177<span class=\"_ _7c\"> </span>2,220<span class=\"_ _e3\"> </span>29<span class=\"_ _3\"></span>,970<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs471\">Charge for the year<span class=\"_ _118\"> </span><span class=\"wsa\">2,208<span class=\"_ _38\"> </span>2,707<span class=\"_ _8d\"> </span>2,253<span class=\"_ _7c\"> </span>3,342<span class=\"_ _6b\"> </span>1,925<span class=\"_ _8c\"> </span>12,<span class=\"_ _25\"></span>435<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs472\">Reclassi\ufb01cation<span class=\"_ _21c\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs473\"><span class=\"_ _2b2\">At 31 December 2021</span><span class=\"_ _19\"> </span><span class=\"wsa\">12,652<span class=\"_ _d7\"> </span>6,226<span class=\"_ _21e\"> </span>6,863<span class=\"_ _15e\"> </span>12,519<span class=\"_ _7c\"> </span>4,1<span class=\"_ _25\"></span>45<span class=\"_ _10d\"> </span>42,405<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs474\">Net book amount at </div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs475\"><span class=\"_ _2b2\">31 December 2021</span><span class=\"_ _21f\"> </span><span class=\"wsa\">12,757<span class=\"_ _e3\"> </span>21,919<span class=\"_ _54\"> </span>3,800<span class=\"_ _12b\"> </span>16,986<span class=\"_ _15b\"> </span>14,266<span class=\"_ _33\"> </span>69,728<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs476\">\u00b9  <span class=\"_ _220\"> </span> <span class=\"_ _1e\"></span>Included within Leasehold Improvements are Assets under Construction of \u00a35,541,<span class=\"_ _25\"></span>000 (2021:\u00a3nil) representing ongoing construction works at Patriots Park, Boston, </div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs477\">which will start being depreciated once completed and in use.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs478\">Leasehold improvements are capital improvements to buildings which the Group leases. Biopr<span class=\"_ _25\"></span>ocessing and laboratory equipment is </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs479\">equipment purchased for the Group\u2019s laboratory and bioprocessing pr<span class=\"_ _25\"></span>ocesses, and are generally movable from one facility to another<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 ls69 ws0 gs47a\">During the year a sale and leaseback transaction was completed on the Windrush facility and as a result assets with a net book value of \u00a37<span class=\"_ _3\"></span><span class=\"_ _2b2\">.5 million</span><span class=\"_ _2\"></span> </div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 ls69 ws0 gs47b\">have been disposed of in the period and a Right of use Asset of \u00a35.<span class=\"_ _25\"></span>8 million recognised at Group. Refer to note 33 for details o<span class=\"_ _25\"></span>f the lease.<span class=\"_ _2b2\"> </span></div>Company<span class=\"_ _2b2\"> </span>Right of use asset<span class=\"ls1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Cost<span class=\"_ _2b2\"> </span>At 1 January 2022<span class=\"_ _221\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _2b2\"> </span></span>Additions at cost<span class=\"_ _222\"> </span><span class=\"wsa\">39<span class=\"_ _25\"></span>,717<span class=\"_ _10c\"> </span>39,717<span class=\"_ _2b2\"> </span></span>At 31 December 2022<span class=\"_ _223\"> </span><span class=\"wsa\">39,<span class=\"_ _25\"></span>717<span class=\"_ _160\"> </span>39,<span class=\"_ _25\"></span>717<span class=\"_ _2b2\"> </span></span>Accumulated depreciation<span class=\"_ _2b2\"> </span>At 1 January 2022<span class=\"_ _221\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _2b2\"> </span></span>Charge for the year<span class=\"_ _224\"> </span><span class=\"wsa\">323<span class=\"_ _82\"> </span>323<span class=\"_ _2b2\"> </span></span>At 31 December 2022<span class=\"_ _1fb\"> </span><span class=\"wsa\">323<span class=\"_ _72\"> </span>323<span class=\"_ _2b2\"> </span></span>Net book amount at<span class=\"ls1\"> </span>31 December 2022<span class=\"_ _1d8\"> </span><span class=\"wsa\">39<span class=\"_ _25\"></span>,394<span class=\"_ _33\"> </span>39,394<span class=\"_ _2b2\"> </span></span>The Windrush Court building was owned and then sold by Oxford Biomedica (UK) Ltd in October 2022, after which the building wasimmediately leased under a 15 year lease by Oxford Biomedica PL<span class=\"_ _25\"></span>C on the same day<span class=\"_ _25\"></span>. In the Company\u2019s individual accounts, the Companyhas accounted for the lease as a standalone lease with the resultant lease liability and matching right of use asset, whilst Oxford Biomedica(UK) Ltd has accounted for the transaction as a standalone sale of an asset. However<span class=\"_ _25\"></span>, from a Group perspective the transaction has beenaccounted for as a sale and leaseback transaction as both companies form part of the same group and both the sale and leaseback wasnegotiated and entered into at the same time. The Company had no property<span class=\"_ _25\"></span><span class=\"_ _2b2\">, plant and equipment at 31 December 2021.</span>13, Assets at fair value through pro\ufb01t and loss<span class=\"_ _2b2\"> </span>Assets at fair value through pro\ufb01t and loss (FVTPL): Group<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>At 1 January<span class=\"_ _225\"> </span><span class=\"ffa ls62 ws5f\">74<span class=\"_ _82\"> </span></span><span class=\"wsa\">239<span class=\"_ _2b2\"> </span></span>Additions<span class=\"_ _226\"> </span><span class=\"ffa ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span>Sale of shares<span class=\"_ _227\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span>Change in fair value of FVTPL asset<span class=\"_ _228\"> </span><span class=\"ffa wsa\">(51)<span class=\"_ _53\"> </span><span class=\"ff9\">(165)<span class=\"_ _2b2\"> </span></span></span>At 31 December<span class=\"_ _19a\"> </span><span class=\"wsa\">23<span class=\"_ _89\"> </span><span class=\"ff9 ls42 ws3a\">74<span class=\"_ _2b2\"> </span></span></span>14<span class=\"_ _25\"></span>, Investments and loans in subsidiaries<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Shares in group undertakings<span class=\"_ _2b2\"> </span>At 1 January and 31 December<span class=\"_ _229\"> </span><span class=\"wsa\">15,182<span class=\"_ _10c\"> </span><span class=\"ff9\">15,182<span class=\"_ _2b2\"> </span></span></span>Loans to group undertakings<span class=\"_ _2b2\"> </span>At 1 January<span class=\"_ _138\"> </span><span class=\"ffa wsa\">273,253<span class=\"_ _d0\"> </span><span class=\"ff9\">262,002<span class=\"_ _2b2\"> </span></span></span>Loan advanced in the year<span class=\"_ _22a\"> </span><span class=\"ffa wsa\">153,602<span class=\"_ _ed\"> </span><span class=\"ff9\">11,251<span class=\"_ _2b2\"> </span></span></span>At 31 December<span class=\"_ _22b\"> </span><span class=\"ffa wsa\">426,855<span class=\"_ _de\"> </span><span class=\"ff9\">273,253<span class=\"_ _2b2\"> </span></span></span>T<span class=\"_ _3\"></span>otal investments in shares and loans to group undertakings<span class=\"_ _86\"> </span><span class=\"wsa\">442,037<span class=\"_ _b9\"> </span><span class=\"ff9\">288<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>435<span class=\"_ _2b2\"> </span></span></span>Accumulated impairment<span class=\"_ _2b2\"> </span>At 1 January and 31 December<span class=\"_ _22c\"> </span><span class=\"ffa wsa\">126,065<span class=\"_ _b9\"> </span><span class=\"ff9\">126,065<span class=\"_ _2b2\"> </span></span></span>Net book amount at 31 December<span class=\"_ _22d\"> </span><span class=\"wsa\">315,972<span class=\"_ _1b5\"> </span><span class=\"ff9\">162,370<span class=\"_ _2b2\"> </span></span></span>Capital contribution in respect of employee share schemes<span class=\"_ _2b2\"> </span>At 1 January<span class=\"_ _19a\"> </span><span class=\"ffa wsa\">18,793<span class=\"_ _160\"> </span><span class=\"ff9\">15,269<span class=\"_ _2b2\"> </span></span></span>Additions in the year (note 27 and 28)<span class=\"_ _22e\"> </span><span class=\"ffa wsa\">6,471<span class=\"_ _8d\"> </span><span class=\"ff9\">3,523<span class=\"_ _2b2\"> </span></span></span>At 31 December<span class=\"_ _1f3\"> </span><span class=\"wsa\">25,264<span class=\"_ _8c\"> </span><span class=\"ff9\">18,<span class=\"_ _25\"></span>792<span class=\"_ _2b2\"> </span></span></span>T<span class=\"_ _3\"></span>otal investments<span class=\"_ _22f\"> </span><span class=\"wsa\">341,237<span class=\"_ _8c\"> </span><span class=\"ff9\">18,<span class=\"_ _25\"></span>792<span class=\"_ _2b2\"> </span></span></span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs4b4\">The Company recognised a loss allowance for expected credit losses on \ufb01nancial assets. The expected credit losses are estima<span class=\"_ _25\"></span>ted by </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs4b5\">reference to an analysis of the subsidiary\u2019s current \ufb01nancial position and futur<span class=\"_ _25\"></span>e repayment expectations. The loss allowance recognised on </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs4b6\"><span class=\"_ _2b2\">loans in subsidiaries at the end of the year was \u00a393.1 million (2021: \u00a393</span><span class=\"_ _25\"></span>.1 million). In addition to the loss allowance recognised on loans in </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs4b7\">subsidiaries, an impairment loss is recognised under IAS 36 for shares in Group undertakings and for capital contribution in r<span class=\"_ _25\"></span>espect</div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs4b8\"><span class=\"_ _2b2\">of employee share schemes of \u00a332.9 million (2021: \u00a332.</span><span class=\"_ _25\"></span>9 million).</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4b9\">The loan from Oxford Biomedica plc to Oxford Biomedica (UK) Limited is unsecured and inter<span class=\"_ _25\"></span>est free. The loan is legally due for </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4ba\">repayment on demand though the expectation is that it will not be repaid within 12 months of the year end. </div><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs4bb\">Net investment in foreign operations:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4bc\">The company has designated a US$180 million intercompany loan to Oxford Biomedica (US) Inc as a monetary item that forms part of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4bd\">the Group\u2019s net investment in Oxford Biomedica Solutions with the foreign ex<span class=\"_ _25\"></span><span class=\"_ _2b2\">change differences recognised as a separate component </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4be\">in Other Comprehensive income until such time as the investment in Oxford Biomedica Solutions is disposed of. A translation gain of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4bf\">\u00a310.<span class=\"_ _25\"></span><span class=\"_ _2b2\">6 million was recognised in 2022 (2021: Nil).<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs4c0\">Interests in subsidiary undertakings<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4c1\">Country of </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs4c2\">incorporation<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs4c3\">Description<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4c4\">of shares held<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4c5\">Proportion of nominal </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4c6\">value of issued shares<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4c7\">held by the Group <span class=\"_ _32\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4c8\">and Company<span class=\"_ _78\"> </span>Nature of business<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4c9\">Oxford Biomedica (UK) Limited<span class=\"_ _85\"> </span>Great Britain<span class=\"_ _1d1\"> </span>1p ordinary shares<span class=\"_ _11c\"> </span><span class=\"wsa\">100%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4ca\">Gene therapy research development<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4cb\">and manufacturing<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4cc\">Oxford Biomedica (Ireland) Limited<span class=\"_ _81\"> </span><span class=\"wsa\">Ireland<span class=\"_ _3a\"> </span></span>1p ordinary shares<span class=\"_ _122\"> </span><span class=\"wsa\">100%<span class=\"_ _16d\"> </span></span>Product release<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4cd\">Oxxon Therapeutics Limited<span class=\"_ _89\"> </span>Great Britain<span class=\"_ _3a\"> </span>1p ordinary shares<span class=\"_ _11c\"> </span><span class=\"wsa\">100%<span class=\"_ _c\"> </span>Dormant<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4ce\">Oxford Biomedica Solutions LL<span class=\"_ _25\"></span>C<span class=\"_ _e6\"> </span>United States<span class=\"_ _51\"> </span><span class=\"wsa\">N/A<span class=\"_ _20\"> </span>80%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4cf\">Gene therapy research, development<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4d0\">and manufacturing<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4d1\">Oxford Biomedica (US) Inc.<span class=\"_ _fb\"> </span>United States<span class=\"_ _f7\"> </span>1c ordinary shares<span class=\"_ _11c\"> </span><span class=\"wsa\">100%<span class=\"_ _230\"> </span></span>Business Development<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs4d2\">Invivusbio Limited<span class=\"_ _231\"> </span>Great Britain<span class=\"_ _3a\"> </span>1p ordinary shares<span class=\"_ _122\"> </span><span class=\"wsa\">100%<span class=\"_ _c\"> </span>Dormant<span class=\"_ _2b2\"> </span></span></div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs4d3\"><span class=\"_ _2b2\">The registered office of the Company</span><span class=\"_ _25\"></span>, its UK subsidiaries and Oxford Biomedica (US) Inc. is Windrush Court, T<span class=\"_ _28\"></span>ransport Way, Oxford, </div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs4d4\">OX4 6L<span class=\"_ _3\"></span>T<span class=\"_ _3\"></span><span class=\"_ _2b2\">. The registered office of Oxford Biomedica (Ireland) Ltd is Earlsfort T</span><span class=\"_ _28\"></span><span class=\"_ _2b2\">errace, Dublin 2, DO2 T380, Ireland. The registered office </span></div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs4d5\">of Oxford Biomedica Solutions LL<span class=\"_ _25\"></span>C is 1 Patriots Park, Bedford, MA 01730<span class=\"_ _25\"></span>, USA.<span class=\"_ _2b2\"> </span></div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs4d6\">In addition, the Group set up the Oxford Biomedica Employee Bene\ufb01t T<span class=\"_ _28\"></span>rust (EBT<span class=\"_ _2\"></span>) to hold market-purchased shar<span class=\"_ _25\"></span>es to settle the 2013 </div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs4d7\">deferred bonus share awards made to Executive Dir<span class=\"_ _25\"></span>ectors and employees (note 27).<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4d8\">All of the above subsidiaries have been consolidated in these \ufb01nancial statements.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4d9\">At each year end the Directors review the carrying value of the Company\u2019s investment in subsidiaries. Where ther<span class=\"_ _25\"></span>e is a material and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4da\">sustained shortfall in the market capitalisation, or a signi\ufb01cant and sustained change in the business resulting in a decrease in mark<span class=\"_ _25\"></span>et </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4db\">capitalisation, the Directors consider this to be a trigger of an impairment review as set out in IAS 36<span class=\"_ _25\"></span>, and the carrying value of the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4dc\">Company\u2019s investments in subsidiaries is adjusted. The Directors consider that reference to the mark<span class=\"_ _25\"></span>et capitalisation of the Group is an </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4dd\">appropriate external measure of the value of the Group f<span class=\"_ _25\"></span>or this purpose. Cumulative impairment of \u00a3126.<span class=\"_ _25\"></span><span class=\"_ _2b2\">0 million has been recognised </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4de\"><span class=\"_ _2b2\">up to 31 December 2022.<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs4df\">15, Inventories<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs4e0\">Group<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs4e1\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs4e2\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs4e3\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs4e4\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs4e5\">Raw Materials<span class=\"_ _232\"> </span><span class=\"ffa wsa\">12,625<span class=\"_ _6b\"> </span><span class=\"ff9\">9,521<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs4e6\">T<span class=\"_ _3\"></span>otal inventory<span class=\"_ _1f2\"> </span><span class=\"wsa\">12,<span class=\"_ _25\"></span>625<span class=\"_ _6b\"> </span><span class=\"ff9\">9,521<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4e7\">Inventories constitute raw materials held for commercial bioprocessing purposes, all of which the Group expects to r<span class=\"_ _25\"></span>ecover within the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4e8\">next 12 months.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4e9\">During the year<span class=\"_ _25\"></span>, the Group wrote down \u00a31,117<span class=\"_ _27\"></span>,000 (2021: \u00a3766,000) o<span class=\"_ _25\"></span>f inventory which is not expected to be used in production or </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4ea\">sold onwards. During the year<span class=\"_ _25\"></span><span class=\"_ _2b2\">, the Group wrote off \u00a311,</span><span class=\"_ _25\"></span>717<span class=\"_ _3\"></span>,000 of inventory as a result o<span class=\"_ _25\"></span>f cancelled orders from a client, which was </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs4eb\">recognised as part of cost of sales in the year<span class=\"_ _25\"></span>. The Company holds no inventories.<span class=\"_ _2b2\"> </span></div>16, T<span class=\"_ _27\"></span>rade and other receivables<span class=\"_ _2b2\"> </span>Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span>Current<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>rade receivables<span class=\"_ _1a2\"> </span><span class=\"ffa wsa\">34,109<span class=\"_ _15b\"> </span><span class=\"ff9\">22,398<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Contract assets<span class=\"_ _233\"> </span><span class=\"ffa wsa\">10,897<span class=\"_ _8c\"> </span><span class=\"ff9\">13,547<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Other receivables<span class=\"_ _1a9\"> </span><span class=\"ffa wsa\">4,832<span class=\"_ _72\"> </span><span class=\"ff9\">365<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Other tax receivable<span class=\"_ _234\"> </span><span class=\"ffa wsa\">7<span class=\"_ _3\"></span>,757<span class=\"_ _38\"> </span><span class=\"ff9\">5,227<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Prepayments<span class=\"_ _235\"> </span><span class=\"ffa\">3,976<span class=\"_ _8d\"> </span></span>3,210<span class=\"_ _9b\"> </span><span class=\"ffa ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span>T<span class=\"_ _3\"></span>otal trade and other receivables<span class=\"_ _96\"> </span><span class=\"wsa\">61,571<span class=\"_ _160\"> </span><span class=\"ff9\">44,<span class=\"_ _25\"></span>747<span class=\"_ _7f\"> </span><span class=\"ffa ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></span>Non-current trade and other receivables constitute other receivables of \u00a35<span class=\"_ _25\"></span>,010<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>000 (2021: \u00a33,<span class=\"_ _25\"></span>605,<span class=\"_ _25\"></span>000) which are deposits held in escrow<span class=\"_ _2b2\"> </span>as part of the Windrush Innovation Centre and Oxbox lease arrangements.<span class=\"_ _2b2\"> </span>The fair value of trade and other receivables are the current book values. The Group has perf<span class=\"_ _25\"></span>ormed an impairment assessment under<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">IFRS 9 and has concluded that the application of the expected credit loss model has had an immaterial impact on the level of impairment<span class=\"_ _2b2\"> </span></span>of receivables.<span class=\"_ _2b2\"> </span>The carrying amounts of the Group\u2019s trade and other receivables are denominated in the following curr<span class=\"_ _25\"></span>encies:<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Sterling<span class=\"_ _236\"> </span><span class=\"ffa\">50,395<span class=\"_ _e3\"> </span></span>44,527<span class=\"_ _2b2\"> </span>US Dollar<span class=\"_ _1a7\"> </span><span class=\"ffa wsa\">16,186<span class=\"_ _7c\"> </span><span class=\"ff9\">3,825</span></span> <span class=\"_ _237\"> </span><span class=\"lsa wsa\">66,581<span class=\"_ _15b\"> </span><span class=\"ff9\">48,352<span class=\"_ _2b2\"> </span></span></span>The maximum exposure to credit risk at the reporting date is the fair value of each class o<span class=\"_ _25\"></span>f receivable above. The Group does not hold<span class=\"_ _2b2\"> </span>any collateral as security.<span class=\"_ _2b2\"> </span>T<span class=\"_ _3\"></span>rade receivables<span class=\"_ _2b2\"> </span>Included in the Group\u2019s trade receivable balance are debtors with a carrying amount of \u00a31,336<span class=\"_ _25\"></span>,000 (2021: \u00a33<span class=\"_ _25\"></span>,800<span class=\"_ _25\"></span>,000) which wer<span class=\"_ _25\"></span>e past<span class=\"_ _2b2\"> </span>due at the reporting date and of which \u00a31,333<span class=\"_ _25\"></span>,000 (2021: \u00a33<span class=\"_ _25\"></span>,800<span class=\"_ _25\"></span>,000) has been received a<span class=\"_ _25\"></span>fter the reporting date.<span class=\"_ _2b2\"> </span>Ageing of past due but not impaired trade receivables:<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>0\u201330 days<span class=\"_ _238\"> </span><span class=\"ffa wsa\">171<span class=\"_ _7c\"> </span><span class=\"ff9\">3,266<span class=\"_ _2b2\"> </span></span></span>30\u201360 days<span class=\"_ _239\"> </span><span class=\"ffa ls1\">3<span class=\"_ _71\"> </span></span><span class=\"wsa\">389<span class=\"_ _2b2\"> </span></span>60+ days<span class=\"_ _225\"> </span><span class=\"ffa wsa\">1,162<span class=\"_ _81\"> </span></span><span class=\"ls55 ws4c\">145<span class=\"_ _2b2\"> </span></span>1,336<span class=\"_ _d7\"> </span><span class=\"ff9\">3,800<span class=\"_ _2b2\"> </span></span>Contract assets<span class=\"_ _2b2\"> </span>Contract assets relates to the Group\u2019s rights to consideration for work completed but not invoiced at the r<span class=\"_ _25\"></span>eporting date for commercial<span class=\"_ _2b2\"> </span>development work and bioprocessing batches. The contract assets are transferred to r<span class=\"_ _25\"></span>eceivables when the rights become unconditional.<span class=\"_ _2b2\"> </span>This usually occurs when the Group issues an invoice to the client.<span class=\"_ _2b2\"> </span>The balance of \u00a310.<span class=\"_ _25\"></span><span class=\"_ _2b2\">9 million (2021: \u00a313.5 million) mainly relates to commer</span><span class=\"_ _25\"></span>cial development milestones which have been accrued as the<span class=\"_ _2b2\"> </span>speci\ufb01c conditions stipulated in the licence agreement have been met, commercial development work orders accrued on a percentage<span class=\"_ _2b2\"> </span>complete basis which will be invoiced as the related work package completes, and bioprocessing batches accrued on a percentage o<span class=\"_ _25\"></span>f<span class=\"_ _2b2\"> </span>completion basis which will be invoiced as the manufacturing of the batch is completed.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Contract assets have decreased from \u00a313.5 million a</span><span class=\"_ _25\"></span>t the end of 2021 to \u00a310.<span class=\"_ _25\"></span><span class=\"_ _2b2\">9 million at the end of 2022 due to the timing of<span class=\"_ _2b2\"> </span></span>bioprocessing and commercial development activities undertaken during the year leading to a lower level of consideration f<span class=\"_ _25\"></span>or work<span class=\"_ _2b2\"> </span>completed but not yet billed.<span class=\"_ _2b2\"> </span>A portion of contract assets relates to \ufb01xed price process development work packages which ar<span class=\"_ _25\"></span>e recognised on a percentage of<span class=\"_ _2b2\"> </span>completion basis and as such requires estimation in terms of the assessment of the correct per<span class=\"_ _25\"></span>centage of completion for that speci\ufb01c<span class=\"_ _2b2\"> </span>work package. The value of the contract asset raised with regard to these work packages is \u00a38<span class=\"_ _25\"></span>,179<span class=\"_ _25\"></span>,000 (2021: \u00a38<span class=\"_ _25\"></span>,022,<span class=\"_ _25\"></span>000). If the assessed<span class=\"_ _2b2\"> </span>percentage of completion was 1 percentage point higher or lower<span class=\"_ _25\"></span>, revenue recognised in the period would ha<span class=\"_ _25\"></span>ve been \u00a382,000 higher<span class=\"ls1\"> </span>or lower (2021: \u00a380,<span class=\"_ _25\"></span>000).<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The Group performed an impairment assessment under IFRS 9 and has concluded that the application of the expected credit loss model<span class=\"_ _2b2\"> </span></span>has had an immaterial impact on the level of impairment on contract assets. We have noted ther<span class=\"_ _25\"></span>e has been no change in the time frame<span class=\"_ _2b2\"> </span>for a right to consideration to become unconditional and the performance obligation to be satis\ufb01ed.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs52d\">17<span class=\"_ _3\"></span>, Cash and cash equivalents<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs52e\">Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs52f\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs530\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs531\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs532\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs533\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs534\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs535\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs536\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs537\">Cash at bank and in hand<span class=\"_ _210\"> </span><span class=\"ffa wsa\">141,285<span class=\"_ _1e0\"> </span><span class=\"ff9\">108,944<span class=\"_ _160\"> </span></span>19,197<span class=\"_ _e3\"> </span><span class=\"ff9\">61,630<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs538\">18, T<span class=\"_ _27\"></span>rade and other payables<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs539\">Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs53a\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs53b\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs53c\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs53d\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs53e\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs53f\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs540\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs541\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs542\">T<span class=\"_ _27\"></span>rade payables<span class=\"_ _e7\"> </span><span class=\"ffa wsa\">13,604<span class=\"_ _21e\"> </span><span class=\"ff9\">5,260<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs543\">Other taxation and social security<span class=\"_ _23a\"> </span><span class=\"ffa wsa\">2,347<span class=\"_ _8d\"> </span><span class=\"ff9\">1,899<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs544\">Accruals<span class=\"_ _23b\"> </span><span class=\"ffa\">20,628<span class=\"_ _23c\"> </span></span>11,899<span class=\"_ _82\"> </span><span class=\"ffa ls48 ws40\">143<span class=\"_ _84\"> </span></span>152<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs545\">T<span class=\"_ _3\"></span>otal trade and other payables<span class=\"_ _23d\"> </span><span class=\"wsa\">36,579<span class=\"_ _15e\"> </span><span class=\"ff9\">19,<span class=\"_ _25\"></span>058<span class=\"_ _82\"> </span><span class=\"ffa ls48 ws40\">143<span class=\"_ _84\"> </span></span>152<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs546\">19, Contract liabilities and deferred income<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs547\">Contract liabilities and deferred income arise when the Group has received payment for services in ex<span class=\"_ _25\"></span>cess of the stage of completion<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs548\">of the services being provided.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs549\">Contract liabilities and deferred income have increased from \u00a315<span class=\"_ _25\"></span><span class=\"_ _2b2\">.2 million at the end of 2021 to \u00a320</span><span class=\"_ _25\"></span>.<span class=\"_ _3\"></span><span class=\"_ _2b2\">4 million at the end of 2022 due</span><span class=\"_ _2\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs54a\">to funds received in advance for future licencing, bioprocessing and process development activities. Of the \u00a312.<span class=\"_ _3\"></span><span class=\"_ _2b2\">6 million balance included</span><span class=\"_ _2\"></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs54b\"><span class=\"_ _2b2\">in the statement of \ufb01nancial position at the end of 2021, \u00a312.5 million has been recognised as revenue during the 2022 \ufb01nancial year</span><span class=\"_ _3\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs54c\">Contract liabilities consists primarily of deferred bioprocessing and process development r<span class=\"_ _25\"></span>evenues, which are expected to be released<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs54d\">as the related performance obligations are satis\ufb01ed over the period as described below:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs54e\"><span class=\"_ _2b2\">At 31 December 2022<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs54f\">0\u20131<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs550\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs551\">1\u20133<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs552\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs553\">3\u20135<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs554\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs555\">5\u201310<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs556\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs557\">T<span class=\"_ _3\"></span>otal<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs558\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs559\">Contract liabilities<span class=\"_ _23e\"> </span><span class=\"wsa\">18,370<span class=\"_ _91\"> </span>32<span class=\"_ _91\"> </span>32<span class=\"_ _34\"> </span>12<span class=\"_ _33\"> </span>18,446<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs55a\">Bioprocessing income<span class=\"_ _23f\"> </span><span class=\"wsa\">10,218<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _23c\"> </span></span><span class=\"wsa\">10,218<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs55b\">Process development income<span class=\"_ _62\"> </span><span class=\"wsa\">3,136<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _38\"> </span></span><span class=\"wsa\">3,136<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs55c\">Licence fees and Milestones<span class=\"_ _15\"> </span><span class=\"wsa\">5,016<span class=\"_ _91\"> </span>32<span class=\"_ _89\"> </span>32<span class=\"_ _e2\"> </span>12<span class=\"_ _7c\"> </span>5,<span class=\"_ _25\"></span>092<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs55d\">Deferred Income<span class=\"_ _240\"> </span><span class=\"wsa\">894<span class=\"_ _21e\"> </span>1,069<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _da\"> </span></span><span class=\"wsa\">1,963<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs55e\">Grant<span class=\"_ _241\"> </span>894<span class=\"_ _8d\"> </span>1,069<span class=\"_ _7f\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _8d\"> </span></span>1,963<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs55f\"><span class=\"_ _2b2\">At 31 December 2021<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs560\">0\u20131<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs561\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs562\">1\u20133<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs563\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs564\">3\u20135<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs565\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs566\">5\u201310<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs567\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs568\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs569\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs56a\">Contract liabilities<span class=\"_ _23e\"> </span><span class=\"wsa\">12,502<span class=\"_ _9a\"> </span>48<span class=\"_ _9a\"> </span>44<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _15b\"> </span></span><span class=\"wsa\">12,594<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs56b\">Bioprocessing income<span class=\"_ _8a\"> </span> 9,755<span class=\"_ _7f\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _38\"> </span></span><span class=\"wsa\">9<span class=\"_ _25\"></span>,755<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs56c\">Process development income<span class=\"_ _b7\"> </span><span class=\"wsa\">2,325<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">2,325<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs56d\">Licence fees and Milestones<span class=\"_ _d2\"> </span><span class=\"wsa\">422<span class=\"_ _76\"> </span>48<span class=\"_ _76\"> </span>44<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _81\"> </span><span class=\"ls55 ws4c\">5<span class=\"_ _2\"></span>14<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs56e\">Deferred Income<span class=\"_ _240\"> </span><span class=\"wsa\">894<span class=\"_ _7c\"> </span>1,760<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _d7\"> </span></span><span class=\"wsa\">2,654<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs56f\">Grant<span class=\"_ _241\"> </span>894<span class=\"_ _38\"> </span>1,760<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _da\"> </span></span>2,654<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs570\">Included within bioprocessing contract liabilities is revenue of \u00a32,592,<span class=\"_ _25\"></span><span class=\"_ _2b2\">000 million which has not been recognised during 2022 (2021: </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs571\">\u00a30.<span class=\"_ _25\"></span><span class=\"_ _2b2\">8 million) relating to the estimate of out of speci\ufb01cation batches (see note 2: \u2019Estima</span><span class=\"_ _25\"></span>tions\u2019 for additional information).<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs572\">Deferred income relates to grant funding received fr<span class=\"_ _25\"></span>om the UK Government for capital equipment purchased as part of the Oxbox </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs573\">bioprocessing facility expansion. The income will be recognised over the period over which the purchased assets are depr<span class=\"_ _25\"></span>eciated.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs574\">The Company had primarily no contract liabilities or deferred income in 2022 or 2021.<span class=\"_ _2b2\"> </span></div>20, Provisions<span class=\"_ _2b2\"> </span>Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>At 1 January<span class=\"_ _187\"> </span><span class=\"ffa wsa\">6,244<span class=\"_ _7c\"> </span><span class=\"ff9\">5,839<span class=\"_ _7f\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Unwinding of discount<span class=\"_ _1f0\"> </span><span class=\"ffa wsa\">66<span class=\"_ _89\"> </span><span class=\"ff9\">27<span class=\"_ _91\"> </span></span>28<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Additional provision recognised<span class=\"_ _94\"> </span><span class=\"ffa ls35 ws64\">3,463<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _da\"> </span></span><span class=\"ffa wsa\">3,207<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Change in estimate<span class=\"_ _1d3\"> </span><span class=\"ffa wsa\">(1,349)<span class=\"_ _82\"> </span><span class=\"ff9\">378<span class=\"_ _85\"> </span></span>(477)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>At 31 December<span class=\"_ _1bd\"> </span><span class=\"ls68 ws6c\">8,424<span class=\"_ _7c\"> </span></span><span class=\"ff9 wsa\">6,2<span class=\"_ _25\"></span>44<span class=\"_ _7c\"> </span><span class=\"ffa\">2,<span class=\"_ _25\"></span>758<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Current<span class=\"_ _1f9\"> </span><span class=\"ffa ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span>Non-current<span class=\"_ _1b3\"> </span><span class=\"ffa ls68 ws6c\">8,424<span class=\"_ _7c\"> </span></span>6,2<span class=\"_ _25\"></span>44<span class=\"_ _da\"> </span><span class=\"ffa\">2,758<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _3\"></span>otal provisions<span class=\"_ _242\"> </span><span class=\"ls68 ws6c\">8,424<span class=\"_ _7c\"> </span></span><span class=\"ff9 wsa\">6,2<span class=\"_ _25\"></span>44<span class=\"_ _7c\"> </span><span class=\"ffa\">2,758<span class=\"_ _7f\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span>Provisions are exclusively in respect of dilapida<span class=\"_ _25\"></span>tions. The new provisions during the year relate to new lease liabilities at theWallingford<span class=\"_ _2b2\"> </span>Warehouse, and as a result o<span class=\"_ _25\"></span>f the sale and leaseback by the Company of the Windrush Court facility the provisions are based on the<span class=\"_ _2b2\"> </span>anticipated costs of restoring the leaseholds at the end of the lease terms, both of which are 2037<span class=\"_ _27\"></span>. The existing dilapidations provisions<span class=\"_ _2b2\"> </span>relate to anticipated costs of restoring the leasehold Y<span class=\"_ _3\"></span><span class=\"_ _2b2\">arnton, Oxbox, Windrush Innovation Centre and Corporate Office properties in<span class=\"_ _2b2\"> </span></span>Oxford, UK to their original condition at the end of the lease terms in 202<span class=\"_ _25\"></span>4, 2033<span class=\"_ _25\"></span>, 2028 and 2030 respectively<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>The future anticipated costs of restoring the properties is calculated by in<span class=\"_ _25\"></span>\ufb02ating the current expected restoration costs using the 3 year<span class=\"_ _2b2\"> </span>historic UK Consumer Price In\ufb02ation rate, up to the end of the lease term. The discount rate utilised for the purpose of determining the<span class=\"_ _2b2\"> </span>present value of the provision is 5.<span class=\"_ _27\"></span>41% based on the risk free rate adjusted for in\ufb02ation. The present value of the future anticipated costs<span class=\"_ _2b2\"> </span>of restoration is calculated by discounting the future expected value using the nominal rate. The unwinding of this discount over time is<span class=\"_ _2b2\"> </span>included within \ufb01nance costs.<span class=\"_ _2b2\"> </span>21, Loans<span class=\"_ _2b2\"> </span>On 10 March 2022, the Group drew down an US$85 million loan facility with Oaktree to \ufb01nance the acquisition of Oxf<span class=\"_ _25\"></span>ord Biomedica<span class=\"_ _2b2\"> </span>Solutions under a 1 year facility agreement maturing in 2023. Over the course of the term loan inter<span class=\"_ _25\"></span>est was payable quarterly with<span class=\"ls1\"> </span>a nominal interest rate on the loan of 8.5%.<span class=\"_ _2b2\"> </span>On 7 October 2022, the loan facility was re\ufb01nanced with Oaktree. Under the terms of such re\ufb01nancing, the Company has partially repaid<span class=\"_ _2b2\"> </span>the outstanding amounts under the Short-<span class=\"_ _3\"></span>T<span class=\"_ _3\"></span>erm Loan Facility and amended the facility into a new senior secured four year term loan<span class=\"_ _2b2\"> </span>facility provided by Oaktree in a principal amount of US$50 million. The T<span class=\"_ _27\"></span>erm Loan will mature four years after the date of completion<span class=\"_ _2b2\"> </span>and will not amortise, with the full aggregate principal and outstanding amount being repayable on the \ufb01nal maturity date. The T<span class=\"_ _28\"></span>erm<span class=\"_ _2\"></span> Loan carries a variable interest rate, which is capped at 10<span class=\"_ _25\"></span>.25% per annum and payable quarterly in cash, with up to 50% of interest for the<span class=\"_ _2b2\"> </span>\ufb01rst twelve months payable in kind as additional loan principal, at the option of the Company<span class=\"_ _25\"></span>. The interest rate is subject to downward<span class=\"_ _2b2\"> </span>adjustment following the satisfaction of certain commercial conditions.<span class=\"_ _2b2\"> </span>The Company also has secured the option, subject to the same commercial conditions as the amended facility and available for a three-<span class=\"_ _2b2\"> </span>year period, to draw down a further US$25 million from Oaktree to fund certain permitted acquisitions. If the option were to be exer<span class=\"_ _25\"></span>cised,<span class=\"_ _2b2\"> </span>it would be assessed against meeting the substantial modi\ufb01cation requirements under IFRS 9<span class=\"_ _3\"></span>.<span class=\"_ _2b2\"> </span>The terms include \ufb01nancial covenants including holding a minimum of US$20 million cash at all times, restrictions on the level<span class=\"_ _2b2\"> </span>of indebtedness the Group may enter into or distributions made by the Group. The Oaktree facility was secured by a pledge over<span class=\"_ _2b2\"> </span>substantially all of the Group\u2019s assets.<span class=\"_ _2b2\"> </span>Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>At 1 January<span class=\"_ _243\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _fb\"> </span></span><span class=\"ws6d\"> \u2013<span class=\"_ _9b\"> </span></span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span>New Loan<span class=\"_ _244\"> </span><span class=\"ffa wsa\">64,866<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _55\"> </span></span><span class=\"ffa wsa\">64,866<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Interest accrued<span class=\"_ _245\"> </span><span class=\"ffa wsa\">5,564<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _d7\"> </span></span><span class=\"ffa wsa\">5,564<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Interest paid<span class=\"_ _1be\"> </span><span class=\"ffa wsa\">(4,554)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _15a\"> </span></span><span class=\"ffa wsa\">(4,554)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Foreign exchange movement<span class=\"_ _182\"> </span><span class=\"ffa wsa\">7<span class=\"_ _3\"></span>,964<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _da\"> </span></span>7<span class=\"_ _25\"></span>,964<span class=\"_ _7f\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span>Amortised fees<span class=\"_ _18d\"> </span><span class=\"ffa wsa\">588<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _71\"> </span></span><span class=\"ffa wsa\">588<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Loan repayment<span class=\"_ _1a0\"> </span><span class=\"ffa wsa\">(31,<span class=\"_ _25\"></span>424)<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _d0\"> </span></span>(31,424)<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span>Arrangement fees<span class=\"_ _246\"> </span><span class=\"ffa wsa\">(3,224)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _15a\"> </span></span><span class=\"ffa wsa\">(3,224)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>At 31 December<span class=\"_ _247\"> </span><span class=\"wsa\">39,<span class=\"_ _25\"></span>780<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _33\"> </span></span>39,780<span class=\"_ _7f\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs5c0\">22, Put option liability<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5c1\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5c2\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5c3\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5c4\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5c5\">At 1 January<span class=\"_ _208\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5c6\">Recognised at fair value<span class=\"_ _248\"> </span><span class=\"ffa wsa\">38,996<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs5c7\">Revaluation<span class=\"_ _1de\"> </span><span class=\"ffa\">(814)<span class=\"_ _7f\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs5c8\">At 31 December<span class=\"_ _1d7\"> </span><span class=\"wsa\">38,182<span class=\"_ _7f\"> </span></span><span class=\"ff9 ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5c9\">On 10th March 2022, the Group recognised a put option liability to acquire the r<span class=\"_ _25\"></span>emaining 20% of Oxford Biomedica Solutions that it </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5ca\">doesn\u2019t already own from Homology Medicines. The fair value of the option at the date of acquisition was assessed to be \u00a339<span class=\"_ _3\"></span>.0 million.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5cb\">At 31st December 2022 the fair value of the Put option liability was \u00a338.2 million (Dec 2021: \u00a3nil). The lower liability valuation was due<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5cc\">to increases in borrowing rates over the period leading to a higher discount rate applied and a resultant lower put option liability<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs5cd\">23, Financial instruments<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5ce\">The Group and Company\u2019s \ufb01nancial instruments comprise cash and cash equivalents, trade and other receivables, assets at fair value </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5cf\">through pro\ufb01t and loss, and trade and other payables. Additional disclosures are set out in the Corpora<span class=\"_ _25\"></span>te Governance Report and in </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5d0\"><span class=\"_ _2b2\">note 3 relating to risk management.<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5d1\"><span class=\"_ _2b2\">The Group had the following \ufb01nancial instruments at 31 December each year: </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5d2\"><span class=\"_ _2b2\">Financial assets\u2009/\u2009\ufb01nancial liabilities </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws58 gs5d3\">at fair value through pro\ufb01t and loss<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5d4\">Cash and receivables<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5d5\">Amortised costs, loans <span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5d6\">and other liabilities<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5d7\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5d8\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5d9\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5da\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5db\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5dc\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5dd\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5de\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5df\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5e0\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5e1\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5e2\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5e3\">Cash and cash equivalents<span class=\"ls1\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5e4\">(note 17)<span class=\"_ _8f\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _cf\"> </span></span><span class=\"lsa wsa\">141,285<span class=\"_ _cf\"> </span><span class=\"ff9\">108,944<span class=\"_ _9b\"> </span></span></span>\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5e5\">T<span class=\"_ _27\"></span>rade receivables and<span class=\"ls1\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5e6\">other receivables (note 16)<span class=\"_ _172\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _15a\"> </span></span><span class=\"lsa wsa\">62,605<span class=\"_ _160\"> </span><span class=\"ff9\">45,142<span class=\"_ _7f\"> </span></span></span>\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5e7\">Assets at fair value through pro\ufb01t </div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5e8\">and loss (note 13)<span class=\"_ _fa\"> </span><span class=\"ffa wsa\">23<span class=\"_ _34\"> </span></span><span class=\"ls42 ws3a\">74<span class=\"_ _9b\"> </span></span><span class=\"ffa ls1\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _7f\"> </span></span>\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5e9\">T<span class=\"_ _27\"></span>rade and other payables<span class=\"_ _2\"></span> </div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5ea\">excluding tax (note 18)<span class=\"_ _249\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _33\"> </span></span><span class=\"lsa wsa\">34,232<span class=\"_ _5e\"> </span><span class=\"ff9\">17<span class=\"_ _3\"></span>,160<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5eb\">Loan (note 21)<span class=\"_ _24a\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _33\"> </span></span><span class=\"lsa wsa\">39,780<span class=\"_ _7f\"> </span></span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5ec\"><span class=\"_ _2b2\">Put option liability (note 22)\u2009\u00b9</span><span class=\"_ _1b\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _15b\"> </span></span><span class=\"lsa wsa\">38,182<span class=\"_ _9b\"> </span></span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5ed\">23<span class=\"_ _91\"> </span><span class=\"ls62 ws5f\">74<span class=\"_ _d0\"> </span></span>203<span class=\"_ _25\"></span>,890<span class=\"_ _d0\"> </span>154,086<span class=\"_ _1b5\"> </span>112,194<span class=\"_ _160\"> </span>17<span class=\"_ _25\"></span>,160<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs5ee\">1 <span class=\"_ _4b\"> </span>Although the put option is included within the amortised cost table, it is not measured a<span class=\"_ _25\"></span>t amortised cost but at the fair value of the expected consideration payable.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5ef\"><span class=\"_ _2b2\">The Company had the following \ufb01nancial instruments at 31 December each year:<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5f0\">Cash and receivables<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5f1\">Amortised costs, loans <span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs5f2\">and other liabilities<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5f3\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5f4\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5f5\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5f6\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5f7\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs5f8\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5f9\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs5fa\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5fb\">Cash and cash equivalents (note 17)<span class=\"_ _24b\"> </span><span class=\"ffa wsa\">19,197<span class=\"_ _e3\"> </span><span class=\"ff9\">61,630<span class=\"_ _7f\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5fc\">T<span class=\"_ _27\"></span>rade and other payables excluding tax (note 18)<span class=\"_ _24c\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _82\"> </span></span><span class=\"ls48 ws40\">143<span class=\"_ _84\"> </span></span></span><span class=\"wsa\">152<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs5fd\">Loan (note 21)<span class=\"_ _1b9\"> </span><span class=\"ffa ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _33\"> </span></span><span class=\"lsa wsa\">39,780<span class=\"_ _9b\"> </span></span><span class=\"ff9\">\u2013</span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 ls1 ws0 gs5fe\"> <span class=\"_ _1e3\"> </span><span class=\"lsa wsa\">19,197<span class=\"_ _e3\"> </span><span class=\"ff9\">61,630<span class=\"_ _12b\"> </span></span>39,923<span class=\"_ _81\"> </span><span class=\"ff9\">152<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs5ff\">Floating rate instant access deposits earned interest at prevailing bank rates.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs600\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs601\">Weighted average </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs602\">rate<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs603\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs604\">Weighted average </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs605\">rate<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs606\">Sterling<span class=\"_ _24d\"> </span><span class=\"ffa\">1.67%<span class=\"_ _ed\"> </span></span><span class=\"ls3f ws36\">0.02<span class=\"_ _2\"></span>%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs607\">US Dollar<span class=\"_ _24e\"> </span><span class=\"ffa wsa\">1.26%<span class=\"_ _5e\"> </span></span><span class=\"ls3f ws36\">0.0<span class=\"_ _2\"></span>0%<span class=\"_ _2b2\"> </span></span></div>Assessment of \ufb01nancial assets by credit risk rating:<span class=\"_ _2b2\"> </span>Cash and cash equivalents are held with reputable banks with a low assessed risk of default.<span class=\"_ _2b2\"> </span>All trade receivables are assessed as having a low credit risk rating as the debt is owed by blue chip pharmaceutical gr<span class=\"_ _25\"></span>oups in the top 10<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">in the world by market capitalisation, and by biotechnology companies with sufficient cash reserves to satisfy their obligations. There<span class=\"_ _2b2\"> </span></span>has been no change in the determined risk during 2022, therefore no reconciliation between the 2021 and 2022 closing debtor balance<span class=\"_ _2b2\"> </span>assessed by risk of default has been provided. The opening and closing position was low (2021: low).<span class=\"_ _2b2\"> </span>Other receivables are rent deposits held in separately administered bank accounts with covenants limiting their use and ar<span class=\"_ _25\"></span>e as such<span class=\"_ _2b2\"> </span>assessed as having a low risk of default.<span class=\"_ _2b2\"> </span>The Group considers a \ufb01nancial asset to be in default when:<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The debtor is unlikely to pay its credit obligation to the Group in full, without recourse by the Gr<span class=\"_ _25\"></span>oup to actions such as realising<span class=\"_ _2b2\"> </span></span>security (if any is held); or<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the \ufb01nancial asset is more than 90 days past its contracted due date.<span class=\"_ _2b2\"> </span></span>Fair value<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The Directors consider that the fair values of the Group\u2019s \ufb01nancial instruments do not differ signi\ufb01cantly from their book values.<span class=\"_ _2b2\"> </span></span>The carrying amounts of the Group\u2019s cash and cash equivalents are denominated in the following currencies:<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Sterling<span class=\"_ _227\"> </span><span class=\"ffa\">117<span class=\"_ _25\"></span>,247<span class=\"_ _160\"> </span><span class=\"ff9\">96,<span class=\"_ _3\"></span>477<span class=\"_ _2b2\"> </span></span></span>Euro<span class=\"_ _24f\"> </span><span class=\"ffa\">623<span class=\"_ _82\"> </span></span><span class=\"ls5d ws59\">524<span class=\"_ _2b2\"> </span></span>US Dollar<span class=\"_ _1a7\"> </span><span class=\"ffa wsa\">23,415<span class=\"_ _23c\"> </span><span class=\"ff9\">11,943<span class=\"_ _2b2\"> </span></span></span>141,285<span class=\"_ _cf\"> </span><span class=\"ff9\">108,944<span class=\"_ _2b2\"> </span></span>Financial assets classi\ufb01ed as level 1 in hierarchy<span class=\"_ _2b2\"> </span>The investment asset represented by ordinary shares in Orchar<span class=\"_ _25\"></span>d Therapeutics is classi\ufb01ed as at fair value through pro\ufb01t and loss.<span class=\"ls1\"> </span>Please refer to note 13 for further information.<span class=\"_ _2b2\"> </span>Financial liabilities classi\ufb01ed as level 3 in hierarchy<span class=\"_ _2b2\"> </span>The Put option liability is classi\ufb01ed as at fair value as a liability. Please r<span class=\"_ _25\"></span>efer to note 22 for further information.<span class=\"_ _2b2\"> </span>Measurement of fair values<span class=\"_ _2b2\"> </span>Valuation techniques and signi\ufb01cant unobservable inputs:<span class=\"_ _2b2\"> </span>The following table shows the valuation techniques used in measuring level 3 fair values, as well as the signi\ufb01cant unobservable inputs used:<span class=\"_ _2b2\"> </span>T<span class=\"_ _25\"></span>ype<span class=\"_ _113\"> </span><span class=\"ws0\">Valuation technique<span class=\"_ _2b2\"> </span></span>Signi\ufb01cant<span class=\"ls1 ws0\"> </span>unobservable inputs<span class=\"_ _2b2\"> </span>Interrelationship between unobservable inputs<span class=\"_ _2b2\"> </span>and fair value measurement:<span class=\"_ _2b2\"> </span>Put option liability<span class=\"_ _71\"> </span>Monte Carlo simulation<span class=\"_ _1b4\"> </span>Revenues of Oxford Biomedica<span class=\"_ _2b2\"> </span>Solutions<span class=\"_ _2b2\"> </span>\u2014  <span class=\"_ _32\"></span>The revenues of Oxford Biomedica Solutions<span class=\"_ _2b2\"> </span>are based on the management approved<span class=\"_ _2b2\"> </span>forecast up until the end of the option period.<span class=\"_ _2b2\"> </span>Should the forecast change or the actual<span class=\"_ _2b2\"> </span>results vary this may impact the value of the<span class=\"_ _2b2\"> </span>put option liability.<span class=\"_ _2b2\"> </span>Discount rate<span class=\"_ _14e\"> </span>\u2014  <span class=\"_ _1e\"></span>The discount rate may be impacted by<span class=\"_ _2b2\"> </span>economic and market factors, as well as<span class=\"_ _2b2\"> </span>changes to the risk free rate of return which<span class=\"_ _2b2\"> </span>impacts debt borrowing rates. Should the<span class=\"_ _2b2\"> </span>discount rate calculated by management be<span class=\"_ _2b2\"> </span>adjusted, this may impact the value of the<span class=\"_ _2b2\"> </span>put option. Management has calculated the<span class=\"_ _2b2\"> </span>discount rate based on the risk free rate,<span class=\"ls1\"> </span>the expected return from similar companies<span class=\"_ _2b2\"> </span>and the Group\u2019s cost of debt.<span class=\"ls1\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h7 ff9 fs4 fcb sc0 lse ws0 gs640\">Sensitivity analysis<span class=\"_ _2b2\"> </span></div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs641\">For the fair values of the put option liability, r<span class=\"_ _25\"></span>easonably possible changes at the reporting date to one of the signi\ufb01cant unobservable inputs, </div><div class=\"t m5 h7 ff9 fs4 fc3 sc0 lse ws0 gs642\"><span class=\"_ _2b2\">holding other inputs constant, would have the following effects:<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs643\">Fair value<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs644\">Put option liability <span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs645\">31 December 2022</div><div class=\"t m1 h9 ffa fs0 fc3 sc0 ls1 ws0 gs646\"> <span class=\"_ _5b\"> </span><span class=\"fs5\"> <span class=\"_ _5b\"> </span><span class=\"ff9\"> <span class=\"_ _1b5\"> </span><span class=\"lsa wsa\">Increase<span class=\"_ _159\"> </span>Decrease<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs647\"><span class=\"_ _2b2\">Effect in thousands of pounds:<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs648\">Revenues of Oxford Biomedica Solutions:<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs649\">10% higher or lower<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs64a\">2.1<span class=\"_ _75\"> </span>(2.<span class=\"_ _3\"></span>4)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs64b\">Discount rate 2% lower or higher<span class=\"_ _1a6\"> </span><span class=\"fs5 ls3c ws33\">1<span class=\"_ _2\"></span>.4<span class=\"_ _72\"> </span><span class=\"lsa wsa\">(1.<span class=\"_ _3\"></span>4<span class=\"_ _2b2\"> </span></span></span><span class=\"fs5 ls3c ws33\"><span class=\"lsa wsa\">)<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs64c\">Reconciliation of movements of liabilities to cash \ufb02ows arising from \ufb01nancing activities<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs64d\">Liabilities<span class=\"_ _117\"> </span>Equity<span class=\"_ _20\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs64e\">Group<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs64f\">Lease<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs650\">liabilities<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs651\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs652\">Loan<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs653\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs654\">Share<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs655\">capital<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs656\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs657\">Share<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs658\">Premium<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs659\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs65a\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs65b\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs65c\">Balance at 1 January 2021<span class=\"_ _17d\"> </span><span class=\"wsa\">13,845<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _e3\"> </span></span><span class=\"wsa\">41,161<span class=\"_ _b9\"> </span>258,017<span class=\"_ _cf\"> </span>313,023<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs65d\">Changes from \ufb01nancing cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs65e\">Share options \u2013 Proceeds from shares issued<span class=\"_ _16c\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _72\"> </span></span><span class=\"wsa\">236<span class=\"_ _6b\"> </span>1,<span class=\"_ _25\"></span>439<span class=\"_ _85\"> </span>1,675<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs65f\">Issue of shares excluding options<span class=\"_ _5\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _85\"> </span></span><span class=\"wsa\">1,691<span class=\"_ _15a\"> </span>48,309<span class=\"_ _15a\"> </span>50,000<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs660\">Payments for the principal portion of lease liabilities<span class=\"_ _6c\"> </span><span class=\"wsa\">(4,520)<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _15b\"> </span></span><span class=\"wsa\">(4,520)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs661\">Payments for the interest portion of lease liabilities<span class=\"_ _ec\"> </span><span class=\"wsa\">(873)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _6c\"> </span></span><span class=\"wsa\">(873)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs662\">T<span class=\"_ _3\"></span>otal changes from \ufb01nancing cash \ufb02ows<span class=\"_ _1c\"> </span><span class=\"wsa\">(5,393)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">1,927<span class=\"_ _33\"> </span>49,<span class=\"_ _25\"></span>748<span class=\"_ _10d\"> </span>46,282<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs663\">Other changes:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs664\">Additions<span class=\"_ _1bf\"> </span>16<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _34\"> </span></span>16<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs665\">Interest<span class=\"_ _250\"> </span>873<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _82\"> </span></span>873<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs666\"><span class=\"_ _2b2\">Balance at 31 December 2021</span><span class=\"_ _8\"> </span><span class=\"wsa\">9,341<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _10d\"> </span></span><span class=\"wsa\">43,088<span class=\"_ _b9\"> </span>307<span class=\"_ _3\"></span>,765<span class=\"_ _d0\"> </span>360,194<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs667\">Changes from \ufb01nancing cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs668\">Share options \u2013 Proceeds from shares issued<span class=\"_ _16c\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _82\"> </span></span><span class=\"wsa\">106<span class=\"_ _91\"> </span>78<span class=\"_ _81\"> </span>184<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs669\">Issue of shares excluding options<span class=\"_ _5\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _da\"> </span></span><span class=\"wsa\">4,<span class=\"_ _25\"></span>938<span class=\"_ _e3\"> </span>75,062<span class=\"_ _55\"> </span>80,000<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs66a\">Cost of share issues<span class=\"_ _15c\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _e3\"> </span></span><span class=\"wsa\">(2,952)<span class=\"_ _15e\"> </span>(2,952)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs66b\">Loans received<span class=\"_ _182\"> </span><span class=\"ls1\">\u2013<span class=\"_ _33\"> </span></span><span class=\"wsa\">64,866<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _12b\"> </span></span><span class=\"wsa\">64,<span class=\"_ _25\"></span>866<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs66c\">Loans repaid<span class=\"_ _112\"> </span><span class=\"ls1\">\u2013<span class=\"_ _109\"> </span></span><span class=\"wsa\">(31,<span class=\"_ _3\"></span>424)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _109\"> </span></span>(31,<span class=\"_ _3\"></span>424)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs66d\">Arrangement fees<span class=\"_ _20e\"> </span><span class=\"ls1\">\u2013<span class=\"_ _e3\"> </span></span><span class=\"wsa\">(3,22<span class=\"_ _25\"></span>4)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _15e\"> </span></span>(3,224)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs66e\">Interest paid<span class=\"_ _7a\"> </span><span class=\"ls1\">\u2013<span class=\"_ _e3\"> </span></span><span class=\"wsa\">(4<span class=\"_ _25\"></span>,554)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _e3\"> </span></span>(4,554)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs66f\">Payments for the principal portion of lease liabilities<span class=\"_ _133\"> </span><span class=\"wsa\">(1,120)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8c\"> </span></span><span class=\"wsa\">(1,120)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs670\">Payments for the interest portion of lease liabilities<span class=\"_ _84\"> </span><span class=\"wsa\">(3,124)<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _160\"> </span></span><span class=\"wsa\">(3,124)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs671\">T<span class=\"_ _3\"></span>otal changes from \ufb01nancing cash \ufb02ows<span class=\"_ _1da\"> </span><span class=\"wsa\">(4,244)<span class=\"_ _33\"> </span>25,664<span class=\"_ _54\"> </span>5,044<span class=\"_ _15b\"> </span>72,188<span class=\"_ _12b\"> </span>98,652<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs672\">Other changes:<span class=\"_ _183\"> </span><span class=\"ls1\"> <span class=\"_ _62\"> </span> <span class=\"_ _51\"> </span> <span class=\"_ _251\"> </span> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs673\">Acquisitions<span class=\"_ _94\"> </span><span class=\"ls3f ws36\">24,9<span class=\"_ _2\"></span>74<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _15e\"> </span></span>24,<span class=\"_ _2\"></span>974<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs674\">Additions<span class=\"_ _9c\"> </span>39,193<span class=\"_ _7f\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _160\"> </span></span>39<span class=\"_ _25\"></span>,193<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs675\">Interest<span class=\"_ _b4\"> </span>3,124<span class=\"_ _7c\"> </span>5<span class=\"_ _25\"></span>,564<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _d7\"> </span></span>8,688<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs676\">Fee amortisation<span class=\"_ _20d\"> </span><span class=\"ls1\">\u2013<span class=\"_ _72\"> </span></span><span class=\"wsa\">588<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _71\"> </span></span><span class=\"wsa\">588<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs677\">Foreign exchange<span class=\"_ _8b\"> </span><span class=\"wsa\">2,113<span class=\"_ _8d\"> </span>7<span class=\"_ _25\"></span>,964<span class=\"_ _7f\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _23c\"> </span></span>10,<span class=\"_ _25\"></span>077<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs678\"><span class=\"_ _2b2\">Closing balance at 31 December 2022</span><span class=\"_ _252\"> </span><span class=\"wsa\">74<span class=\"_ _25\"></span>,501<span class=\"_ _12b\"> </span>39,<span class=\"_ _25\"></span>780<span class=\"_ _15b\"> </span>48,132<span class=\"_ _cf\"> </span>379,<span class=\"_ _25\"></span>953<span class=\"_ _d0\"> </span>542,366<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs67a\">Liabilities<span class=\"_ _117\"> </span>Equity<span class=\"_ _20\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs67b\">Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs67c\">Lease<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs67d\">liabilities<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs67e\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs67f\">Loan<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs680\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs681\">Share<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs682\">capital<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs683\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs684\">Share<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs685\">Premium<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs686\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs687\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs688\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs689\">Balance at 1 January 2021<span class=\"_ _253\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _160\"> </span></span><span class=\"wsa\">41,161<span class=\"_ _cf\"> </span>258,017<span class=\"_ _cf\"> </span>299,178<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs68a\">Changes from \ufb01nancing cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs68b\">Share options \u2013 Proceeds from shares issued<span class=\"_ _16c\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _72\"> </span></span><span class=\"wsa\">236<span class=\"_ _6b\"> </span>1,<span class=\"_ _25\"></span>439<span class=\"_ _85\"> </span>1,675<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs68c\">Issue of shares excluding options<span class=\"_ _5\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _85\"> </span></span><span class=\"wsa\">1,691<span class=\"_ _15a\"> </span>48,309<span class=\"_ _15a\"> </span>50,000<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs68d\">T<span class=\"_ _3\"></span>otal changes from \ufb01nancing cash \ufb02ows<span class=\"_ _116\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">1,927<span class=\"_ _33\"> </span>49,748<span class=\"_ _e3\"> </span>51,675<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs68e\"><span class=\"_ _2b2\">Balance at 31 December 2021</span><span class=\"_ _176\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _10d\"> </span></span><span class=\"wsa\">43,088<span class=\"_ _b9\"> </span>307<span class=\"_ _3\"></span>,765<span class=\"_ _1e0\"> </span>350<span class=\"_ _25\"></span>,853<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs68f\">Changes from \ufb01nancing cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs690\">Share options \u2013 Proceeds from shares issued<span class=\"_ _16c\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _82\"> </span></span><span class=\"wsa\">106<span class=\"_ _91\"> </span>78<span class=\"_ _81\"> </span>184<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs691\">Issue of shares excluding options<span class=\"_ _5\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _da\"> </span></span><span class=\"wsa\">4,<span class=\"_ _25\"></span>938<span class=\"_ _e3\"> </span>75,062<span class=\"_ _55\"> </span>80,000<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs692\">Cost of share issues<span class=\"_ _15c\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _e3\"> </span></span><span class=\"wsa\">(2,952)<span class=\"_ _15e\"> </span>(2,952)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs693\">Loans received<span class=\"_ _182\"> </span><span class=\"ls1\">\u2013<span class=\"_ _33\"> </span></span><span class=\"wsa\">64,866<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _12b\"> </span></span><span class=\"wsa\">64,<span class=\"_ _25\"></span>866<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs694\">Loans repaid<span class=\"_ _112\"> </span><span class=\"ls1\">\u2013<span class=\"_ _109\"> </span></span><span class=\"wsa\">(31,<span class=\"_ _3\"></span>424)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _109\"> </span></span>(31,<span class=\"_ _3\"></span>424)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs695\">Interest paid<span class=\"_ _7a\"> </span><span class=\"ls1\">\u2013<span class=\"_ _e3\"> </span></span><span class=\"wsa\">(4<span class=\"_ _25\"></span>,554)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _e3\"> </span></span>(4,554)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs696\">Arrangement fees<span class=\"_ _20e\"> </span><span class=\"ls1\">\u2013<span class=\"_ _e3\"> </span></span><span class=\"wsa\">(3,22<span class=\"_ _25\"></span>4)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _15e\"> </span></span>(3,224)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs697\">Payments for the principal portion of lease liabilities<span class=\"_ _251\"> </span><span class=\"wsa\">55<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _89\"> </span></span><span class=\"wsa\">55<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs698\">Payments for the interest portion of lease liabilities<span class=\"_ _5a\"> </span><span class=\"wsa\">(477)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _53\"> </span></span><span class=\"wsa\">(477)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs699\">T<span class=\"_ _3\"></span>otal changes from \ufb01nancing cash \ufb02ows<span class=\"_ _16c\"> </span><span class=\"wsa\">(422)<span class=\"_ _33\"> </span>25,664<span class=\"_ _d7\"> </span>5,<span class=\"_ _25\"></span>044<span class=\"_ _15b\"> </span>72,188<span class=\"_ _1e0\"> </span>102,474<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs69a\">Other changes:<span class=\"_ _183\"> </span><span class=\"ls1\"> <span class=\"_ _62\"> </span> <span class=\"_ _251\"> </span> <span class=\"_ _51\"> </span> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs69b\">Additions<span class=\"_ _9c\"> </span>35<span class=\"_ _25\"></span>,567<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _15e\"> </span></span>35,567<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs69c\">Interest<span class=\"_ _254\"> </span>477<span class=\"_ _7c\"> </span>5,564<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8d\"> </span></span>6,041<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs69d\">Fee amortisation<span class=\"_ _20d\"> </span><span class=\"ls1\">\u2013<span class=\"_ _72\"> </span></span><span class=\"wsa\">588<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _71\"> </span></span><span class=\"wsa\">588<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs69e\">Foreign exchange<span class=\"_ _23d\"> </span><span class=\"ls1\">\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">7<span class=\"_ _3\"></span>,964<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _8d\"> </span></span>7<span class=\"_ _3\"></span>,964<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs69f\"><span class=\"_ _2b2\">Closing balance at 31 December 2022</span><span class=\"_ _cd\"> </span><span class=\"wsa\">35,622<span class=\"_ _33\"> </span>39,780<span class=\"_ _12b\"> </span>48,132<span class=\"_ _b9\"> </span>379<span class=\"_ _25\"></span>,953<span class=\"_ _d0\"> </span>503,487<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h6 ff9 fs3 fcb sc0 ls4 ws4 gs6a0\">NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs6a1\"><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs6a3\">Exposure to Liquidity Risk<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6a4\">Contractual Cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs6a5\">Group <span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs6a6\">At 31 December 2022<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6a7\">Carrying<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6a8\">Amount<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6a9\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6aa\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span> <span class=\"_ _2f\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6ab\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6ac\">2 months<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6ad\">or less <span class=\"_ _1e\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6ae\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6af\">2\u201312<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6b0\">months<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6b1\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6b2\">1\u20132 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6b3\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6b4\">2\u20135 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6b5\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6b6\">&gt;5 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6b7\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs6b8\">Lease Liabilities<span class=\"_ _117\"> </span><span class=\"wsa\">7<span class=\"_ _25\"></span>4,501<span class=\"_ _158\"> </span>119,496<span class=\"_ _eb\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _169\"> </span></span>9,179<span class=\"_ _167\"> </span>18,681<span class=\"_ _167\"> </span>24,353<span class=\"_ _167\"> </span>67<span class=\"_ _3\"></span>,283<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs6b9\">Loans<span class=\"_ _255\"> </span>39,<span class=\"_ _25\"></span>780<span class=\"_ _3d\"> </span>59,<span class=\"_ _25\"></span>082<span class=\"_ _eb\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _22\"> </span></span>4,294<span class=\"_ _22\"> </span>4,306<span class=\"_ _3d\"> </span>50,<span class=\"_ _25\"></span>482<span class=\"_ _eb\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6ba\">Contractual Cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs6bb\">Group <span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs6bc\">At 31 December 2021<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6bd\">Carrying<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6be\">Amount<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6bf\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6c0\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span> <span class=\"_ _2f\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6c1\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6c2\">2 months<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6c3\">or less <span class=\"_ _1e\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6c4\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6c5\">2\u201312<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6c6\">months<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6c7\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6c8\">1\u20132 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6c9\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6ca\">2\u20135 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6cb\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6cc\">&gt;5 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6cd\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6ce\">Lease Liabilities<span class=\"_ _ac\"> </span><span class=\"wsa\">9<span class=\"_ _25\"></span>,341<span class=\"_ _c4\"> </span>13,<span class=\"_ _25\"></span>456<span class=\"_ _eb\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _169\"> </span></span>1,590<span class=\"_ _169\"> </span>3,033<span class=\"_ _134\"> </span>2,850<span class=\"_ _169\"> </span>5,983<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6cf\">Loans<span class=\"_ _256\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _53\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6d0\">Contractual Cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs6d1\">Company <span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs6d2\">At 31 December 2022<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6d3\">Carrying<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6d4\">Amount<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6d5\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6d6\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span> <span class=\"_ _2f\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6d7\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6d8\">2 months<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6d9\">or less <span class=\"_ _1e\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6da\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6db\">2\u201312<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6dc\">months<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6dd\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6de\">1\u20132 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6df\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6e0\">2\u20135 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6e1\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6e2\">&gt;5 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6e3\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs6e4\">Lease Liabilities<span class=\"_ _d1\"> </span><span class=\"wsa\">35,622<span class=\"_ _3d\"> </span>63,226<span class=\"_ _10\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _22\"> </span></span><span class=\"wsa\">3,500<span class=\"_ _134\"> </span>7<span class=\"_ _25\"></span>,000<span class=\"_ _154\"> </span>6,300<span class=\"_ _257\"> </span>46,426<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs6e5\">Loans<span class=\"_ _255\"> </span>39,<span class=\"_ _25\"></span>780<span class=\"_ _3d\"> </span>59,<span class=\"_ _25\"></span>082<span class=\"_ _eb\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _22\"> </span></span>4,294<span class=\"_ _22\"> </span>4,306<span class=\"_ _3d\"> </span>50,<span class=\"_ _25\"></span>482<span class=\"_ _eb\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6e6\">Contractual Cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs6e7\">Company <span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs6e8\">At 31 December 2021<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6e9\">Carrying<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6ea\">Amount<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6eb\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6ec\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span> <span class=\"_ _2f\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6ed\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6ee\">2 months<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6ef\">or less <span class=\"_ _1e\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6f0\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6f1\">2\u201312<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6f2\">months<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6f3\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6f4\">1\u20132 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6f5\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6f6\">2\u20135 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6f7\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6f8\">&gt;5 years<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6f9\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs6fa\">Lease Liabilities<span class=\"_ _195\"> </span><span class=\"ls1\">\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _53\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs6fb\">Loans<span class=\"_ _256\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _53\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _eb\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs6fc\">24, Deferred taxa<span class=\"_ _25\"></span>tion<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs6fd\">U.K. deferred tax<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs6fe\">The Group has recognised UK deferred tax assets and liabilities at 31 December 2022 and 31 December 2021. In light of the Gr<span class=\"_ _25\"></span>oup\u2019s </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs6ff\"><span class=\"_ _2b2\">history of losses, recovery of the whole deferred tax asset is not sufficiently certain, and theref</span><span class=\"_ _25\"></span>ore a deferred tax asset has been </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs700\">recognised only to the extent that there is a deferred tax liability<span class=\"_ _25\"></span>. </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs701\">Finance Act 2020 enacted provisions to increase the UK Corporation tax rate to 19% from 1 April 2021. Finance Act 2021 which was </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs702\">Substantively Enacted on 24 May 2022 included provisions to incr<span class=\"_ _25\"></span><span class=\"_ _2b2\">ease the rate further to 25% effective from 1 April 2023 and this rate has </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs703\">been applied when calculating the UK deferred tax at the year end.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs704\">U.S. deferred tax<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs705\">The Group have recognised US deferred tax assets and liabilities at 31 December 2022 (31 December 2021: Nil). </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs706\">The remaining deferred tax assets have not been recognised as ther<span class=\"_ _25\"></span>e is uncertainty regarding when suitable future pro\ufb01ts against which </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs707\"><span class=\"_ _2b2\">to offset the tax losses will arise.<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs708\">U<span class=\"_ _25\"></span>.S. deferred tax assets and liabilities are calculated at a blended rate o<span class=\"_ _25\"></span>f approximately 28%.<span class=\"_ _2b2\"> </span></div>Group \u2013 recognised<span class=\"ls1\"> </span>Deferred tax (assets)/liabilities \u2013 recognised<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>rading temporary<span class=\"_ _2\"></span> <span class=\"_ _2b2\">differences</span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Fixed assets<span class=\"ls1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>ax losses<span class=\"_ _2\"></span><span class=\"ls1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Intangible assets<span class=\"ls1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>At 1 January 2022<span class=\"_ _258\"> </span><span class=\"ls1\">\u2013<span class=\"_ _38\"> </span></span><span class=\"wsa\">3,051<span class=\"_ _160\"> </span>(3,051)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _2b2\"> </span></span>Arising on acquisition<span class=\"_ _219\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _85\"> </span></span><span class=\"wsa\">7<span class=\"_ _3\"></span>,397<span class=\"_ _85\"> </span>7<span class=\"_ _25\"></span>,397<span class=\"_ _2b2\"> </span></span>Foreign exchange<span class=\"_ _23d\"> </span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _71\"> </span></span><span class=\"wsa\">508<span class=\"_ _71\"> </span>508<span class=\"_ _2b2\"> </span></span>Income statement credit<span class=\"_ _24c\"> </span><span class=\"wsa\">(1,256)<span class=\"_ _71\"> </span>306<span class=\"_ _85\"> </span>(439)<span class=\"_ _af\"> </span>(403)<span class=\"_ _8c\"> </span>(1,792)<span class=\"_ _2b2\"> </span></span>At 31 December 2022<span class=\"_ _259\"> </span><span class=\"wsa\">(1,256)<span class=\"_ _7c\"> </span>3,357<span class=\"_ _15a\"> </span>(3,490)<span class=\"_ _7c\"> </span>7<span class=\"_ _3\"></span>,502<span class=\"_ _38\"> </span>6,113<span class=\"_ _2b2\"> </span></span>At 1 January 2021<span class=\"_ _25a\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">Origination and reversal of temporary differences</span><span class=\"_ _121\"> </span><span class=\"ls1\">\u2013<span class=\"_ _6b\"> </span></span><span class=\"wsa\">3,<span class=\"_ _25\"></span>051<span class=\"_ _23c\"> </span>(3,<span class=\"_ _25\"></span>051)<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></span>At 31 December 2021<span class=\"_ _24b\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">3,051<span class=\"_ _15b\"> </span>(3,051)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _2b2\"> </span></span>Group \u2013 not recognised<span class=\"ls1\"> </span>Deferred tax (assets)/liabilities \u2013 <span class=\"ls1\"> </span>not recognised<span class=\"_ _2b2\"> </span>Intangibles<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Loan <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>relationships<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Provisions<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>ax losses<span class=\"_ _2\"></span><span class=\"ls1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Share options<span class=\"ls1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>At 1 January 2022<span class=\"_ _25b\"> </span><span class=\"ls1\">\u2013<span class=\"_ _15e\"> </span></span><span class=\"wsa\">(1,668)<span class=\"_ _85\"> </span>(298)<span class=\"_ _de\"> </span>(21,760)<span class=\"_ _23c\"> </span>(6,176)<span class=\"_ _cf\"> </span>(29,902)<span class=\"_ _2b2\"> </span></span>Origination and reversal of<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">temporary differences</span><span class=\"_ _19\"> </span><span class=\"wsa\">(4,819)<span class=\"_ _8d\"> </span>1,668<span class=\"_ _76\"> </span>50<span class=\"_ _20f\"> </span>3,511<span class=\"_ _85\"> </span>3,871<span class=\"_ _8d\"> </span>4,281<span class=\"_ _2b2\"> </span></span>At 31 December 2022<span class=\"_ _120\"> </span><span class=\"wsa\">(4,819)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _38\"> </span></span><span class=\"wsa\">(248)<span class=\"_ _1e0\"> </span>(18,2<span class=\"_ _25\"></span>49)<span class=\"_ _33\"> </span>(2,305)<span class=\"_ _cf\"> </span>(25,621)<span class=\"_ _2b2\"> </span></span>At 1 January 2021<span class=\"_ _a6\"> </span><span class=\"ls1\">\u2013<span class=\"_ _160\"> </span></span><span class=\"wsa\">(1,267)<span class=\"_ _af\"> </span>(206)<span class=\"_ _b9\"> </span></span> (17<span class=\"_ _3\"></span>,<span class=\"_ _3\"></span>443)<span class=\"_ _15e\"> </span><span class=\"wsa\">(3,239)<span class=\"_ _1e0\"> </span></span> (22,155)<span class=\"_ _2b2\"> </span>Origination and reversal <span class=\"ls1\"> </span><span class=\"_ _2b2\">of temporary differences</span><span class=\"_ _25c\"> </span><span class=\"ls1\">\u2013<span class=\"_ _20f\"> </span></span><span class=\"wsa\">(401)<span class=\"_ _82\"> </span>(92)<span class=\"_ _33\"> </span></span> (4,317)<span class=\"_ _160\"> </span><span class=\"wsa\">(2,937)<span class=\"_ _15b\"> </span></span> (7<span class=\"_ _25\"></span>,7<span class=\"_ _25\"></span>47)<span class=\"_ _2b2\"> </span>At 31 December 2021<span class=\"_ _14f\"> </span><span class=\"ls1\">\u2013<span class=\"_ _33\"> </span></span><span class=\"wsa\">(1,668)<span class=\"_ _6b\"> </span>(298)<span class=\"_ _169\"> </span></span> (21,760)<span class=\"_ _15b\"> </span><span class=\"wsa\">(6,176)<span class=\"_ _134\"> </span></span> (29,<span class=\"_ _25\"></span>902)<span class=\"_ _2b2\"> </span>Oxford Biomedica PL<span class=\"_ _25\"></span>C has unrecognised deferred tax assets of \u00a335<span class=\"_ _25\"></span>,000 r<span class=\"_ _25\"></span><span class=\"_ _2b2\">elating to non temporary trading differences.<span class=\"_ _2b2\"> </span></span>25, Ordinary shares<span class=\"_ _2b2\"> </span>Group and Company<span class=\"ls1\"> </span>Issued and fully paid<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Ordinary shares of 50p each<span class=\"_ _2b2\"> </span>At 1 January \u2013 86,175,<span class=\"_ _25\"></span>055 (2021: 82,320<span class=\"_ _25\"></span>,585) shares<span class=\"_ _25d\"> </span><span class=\"ffa wsa\">43,088<span class=\"_ _5e\"> </span><span class=\"ff9\">41,161<span class=\"_ _2b2\"> </span></span></span>Allotted for cash in placing and subscription \u2013 9<span class=\"_ _25\"></span>,876,544 (2021: 3<span class=\"_ _25\"></span>,382,950) shares<span class=\"_ _24c\"> </span><span class=\"ffa wsa\">4<span class=\"_ _25\"></span>,938<span class=\"_ _85\"> </span><span class=\"ff9\">1,691<span class=\"_ _2b2\"> </span></span></span>Allotted on exercise of share options \u2013 212,<span class=\"_ _25\"></span>646 (2021: 471,520)<span class=\"_ _254\"> </span><span class=\"ffa wsa\">106<span class=\"_ _82\"> </span><span class=\"ff9\">236<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">At 31 December \u2013 96,263,165 (2021: 86,175,</span><span class=\"_ _25\"></span>055) shares<span class=\"_ _1b0\"> </span><span class=\"wsa\">48,132<span class=\"_ _12b\"> </span><span class=\"ff9\">43,<span class=\"_ _25\"></span>088<span class=\"_ _2b2\"> </span></span></span>The share capital of the Company consists only of fully paid ordinary shares with a nominal (par) value of \u00a30<span class=\"_ _25\"></span>.50 per share. There ar<span class=\"_ _25\"></span>e<span class=\"ls1\"> </span>no restrictions on the ability of shareholders to receive dividends, nor on the repayment o<span class=\"_ _25\"></span>f capital. All ordinary shares are equally eligible<span class=\"_ _2b2\"> </span>to receive dividends and the repayment of capital in accordance with the Company\u2019s Articles of Association and r<span class=\"_ _25\"></span>epresent one vote<span class=\"ls1\"> </span>at shareholders\u2019 meetings of the Company<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>As part of the \ufb01nancing arrangements for the Oxford Biomedica Solutions acquisition, the Group raised gross pr<span class=\"_ _25\"></span><span class=\"_ _2b2\">oceeds of \u00a380 million through<span class=\"_ _2b2\"> </span></span>a placing of 9<span class=\"_ _25\"></span>,876,544 shar<span class=\"_ _25\"></span>es at \u00a38.10 per share. The placing was done in 2 tranches with 5<span class=\"_ _25\"></span>,018<span class=\"_ _25\"></span>,134 shares placed on 28 January 2022, and a<span class=\"_ _2b2\"> </span>further 4,<span class=\"_ _25\"></span>858,<span class=\"_ _3\"></span>410 shares were placed on 10 March 2022.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs74d\">26, Share premium account<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs74e\">Group and Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs74f\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs750\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs751\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs752\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs753\">At 1 January<span class=\"_ _138\"> </span><span class=\"ffa wsa\">307<span class=\"_ _3\"></span>,765<span class=\"_ _ee\"> </span><span class=\"ff9\">258,017<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs754\">Premium on shares issued for cash in placing and subscription<span class=\"_ _25e\"> </span><span class=\"ffa wsa\">75,062<span class=\"_ _33\"> </span><span class=\"ff9\">48,309<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs755\">Premium on exercise of share options<span class=\"_ _25f\"> </span><span class=\"ffa wsa\">78<span class=\"_ _6b\"> </span><span class=\"ff9\">1,<span class=\"_ _25\"></span>439<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs756\">Costs associated with the issue of shares<span class=\"_ _260\"> </span><span class=\"ffa wsa\">(2,952)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs757\">At 31 December<span class=\"_ _22b\"> </span><span class=\"wsa\">379,<span class=\"_ _25\"></span>953<span class=\"_ _ee\"> </span><span class=\"ff9\">307<span class=\"_ _3\"></span>,765<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs758\">27<span class=\"_ _3\"></span>, Options over shares of Oxford Biomedica plc<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs759\">The Company has outstanding share options that were issued under the following schemes:</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs75a\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The 2007 Share Option Scheme (approved February 2007)</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs75b\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The 2015 Executive Share Option Scheme (approved May 2015)</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs75c\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The 2007 Long T<span class=\"_ _27\"></span>erm Incentive Plan (L<span class=\"_ _3\"></span>TIP) (approved February 2007)</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs75d\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The 2015 Long T<span class=\"_ _27\"></span>erm Incentive Plan (L<span class=\"_ _3\"></span>TIP) (approved May 2015)</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs75e\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The 2013 Deferred Bonus Plan (approved February 201<span class=\"_ _25\"></span>4)</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs75f\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The 2015 Deferred Bonus Plan (approved May 2015)</span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs760\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">The 2015 Sharesave scheme (approved May 2015)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs761\">Share options are granted to Executive Directors and selected senior managers under the Company\u2019s Long T<span class=\"_ _28\"></span>erm Incentive Plans (L<span class=\"_ _25\"></span>TIP), </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs762\">and Deferred Bonus Plans, and to other employees under the Share Option Schemes and Sharesave scheme. All option grants ar<span class=\"_ _25\"></span>e at the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs763\">discretion of the Remuneration Committee. All options granted are equity settled share options, but deferr<span class=\"_ _25\"></span>ed share awards may be settled </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs764\">in cash at the option of the Remuneration committee.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs765\">Options and RSUs granted under the 2007 and 2015 L<span class=\"_ _3\"></span>TIP to Directors and other senior managers are subject to both revenue and market </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs766\">condition performance criteria and will vest only if, at the third anniversary of the grant, the performance criteria have been met. F<span class=\"_ _25\"></span>ailure to </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs767\">meet the minimum performance criteria by the third anniversary results in all the granted options lapsing.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs768\">The performance criteria are described in the Directors\u2019 Remuneration Report. L<span class=\"_ _27\"></span>TIP awards made to date are exercisable at either par or at </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs769\">nil cost on the third anniversary of the date of grant, and lapse 10 years after being granted. For Directors, options granted between 2019 </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs76a\">and 2021 also have a 2 year holding period post vesting.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs76b\">Restricted stock units (RSUs) granted to employees under the 2015 L<span class=\"_ _3\"></span>TIP are issued at nil cost. They are not subject to market condition </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs76c\">performance criteria and the lives of the RSUs are ten years, after which the RSUs expire. RSUs granted under the 2015 Scheme cannot </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs76d\">normally be exercised before the third anniversary o<span class=\"_ _25\"></span>f the date of grant. RSUs are valued based on the market price at the date of grant.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs76e\">Options granted under the 2007 Share Option Scheme have \ufb01xed exercise prices based on the mark<span class=\"_ _25\"></span>et price at the date of grant. They<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs76f\">are not subject to market condition performance criteria and the lives of the options are ten years, a<span class=\"_ _25\"></span>fter which the options expire. Options </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs770\">granted prior to 2012 cannot normally be exercised before the third anniversary o<span class=\"_ _25\"></span>f the date of grant. Options granted under the 2007 </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs771\">Scheme during 2012 to 2014<span class=\"_ _25\"></span>, with one exception, vest in tranches of 25% from the \ufb01rst to fourth anniversaries o<span class=\"_ _25\"></span>f the grant dates.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs772\">Options granted under the 2015 Executive Share Option Scheme have \ufb01xed ex<span class=\"_ _25\"></span>ercise prices based on the market price at the date of </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs773\">grant. They are not subject to market condition performance criteria and the lives of the options are ten years, a<span class=\"_ _25\"></span>fter which the options </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs774\">expire. Options granted under the 2015 Scheme cannot normally be exercised before the thir<span class=\"_ _25\"></span>d anniversary of the date of grant.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs775\">Options granted under the 2015 Sharesave Scheme have \ufb01xed exer<span class=\"_ _25\"></span>cise prices based on the market price at the date of grant. They are not </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs776\">subject to market condition performance criteria and the lives of the options are four years, after which the options expir<span class=\"_ _25\"></span>e and the cash </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs777\">saved is returned. Options cannot be exercised befor<span class=\"_ _25\"></span>e the third anniversary of the date of grant.<span class=\"_ _2b2\"> </span></div><span class=\"_ _2b2\">Share options outstanding at 31 December 2022 have the following expiry date and exer</span><span class=\"_ _25\"></span>cise prices:<span class=\"_ _2b2\"> </span>Options granted to employees under the Oxford Biomedica 2007 and 2015 Share Option Schemes<span class=\"ls1\"> </span>2022 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>Number of shares<span class=\"_ _2b2\"> </span>2021 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>Number of shares<span class=\"_ _2b2\"> </span>Exercise price <span class=\"_ _32\"></span><span class=\"ls1\"> </span>per share<span class=\"_ _2b2\"> </span>Date from <span class=\"_ _32\"></span><span class=\"ls1\"> </span>which exercisable<span class=\"_ _1b\"> </span>Expiry date<span class=\"_ _2b2\"> </span>\u2013 <span class=\"_ _6d\"> </span><span class=\"ff9 lsa wsa\">5,560<span class=\"_ _e4\"> </span><span class=\"ws0\">115p to 155p<span class=\"_ _21\"> </span></span>Vested<span class=\"_ _7c\"> </span><span class=\"ws0\">08/05/22 to 21/12/22<span class=\"_ _2b2\"> </span></span></span>12,860<span class=\"_ _6d\"> </span><span class=\"ff9\">15,155<span class=\"_ _9b\"> </span><span class=\"ws0\">80p to 1<span class=\"_ _25\"></span>40p<span class=\"_ _21\"> </span><span class=\"wsa\">Vested<span class=\"_ _85\"> </span></span>22/05/23 to 19/11/23<span class=\"_ _2b2\"> </span></span></span>16,518<span class=\"_ _2b\"> </span><span class=\"ff9\">16<span class=\"_ _25\"></span>,518<span class=\"_ _79\"> </span><span class=\"ws0\">100p to 200p<span class=\"_ _21\"> </span></span>Vested<span class=\"_ _21e\"> </span><span class=\"ws0\">03/06/24 to 17/10/24<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">38,170\u2009\u00b9</span><span class=\"_ _12a\"> </span><span class=\"ff9\">39<span class=\"_ _3\"></span>,873\u00b9<span class=\"_ _120\"> </span>490p<span class=\"_ _21\"> </span>Vested<span class=\"_ _21e\"> </span><span class=\"ws0\">13/03/25 to 10/06/25<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">52,689\u2009\u00b9</span><span class=\"_ _261\"> </span><span class=\"ff9\">55,309\u00b9<span class=\"_ _67\"> </span>275p<span class=\"_ _d9\"> </span>Vested<span class=\"_ _7c\"> </span><span class=\"ws0\">16/05/26 to 13/10/26<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">95,927\u2009\u00b9</span><span class=\"_ _11a\"> </span><span class=\"ff9\">106,<span class=\"_ _25\"></span>026\u00b9<span class=\"_ _128\"> </span>495p<span class=\"_ _21\"> </span>Vested<span class=\"_ _bc\"> </span><span class=\"ws0\">13/07/2017 to 13/07/27<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">120,903\u2009\u00b9</span><span class=\"_ _60\"> </span><span class=\"ff9\">141,060\u00b9<span class=\"_ _88\"> </span><span class=\"ws0\">502p to 904p<span class=\"_ _21\"> </span></span>Vested <span class=\"_ _158\"> </span><span class=\"ws0\">15/02/2028 to 07 08 2028<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">326,889\u2009\u00b9</span><span class=\"_ _11a\"> </span><span class=\"ff9\">379<span class=\"_ _25\"></span>,808\u00b9<span class=\"_ _76\"> </span><span class=\"ws0\">618p to 705p<span class=\"_ _21\"> </span></span>Vested <span class=\"_ _cc\"> </span><span class=\"ws0\">04/01/2029 to 12/09/2029<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">458,426\u2009\u00b9</span><span class=\"_ _11a\"> </span><span class=\"ff9\">520<span class=\"_ _25\"></span><span class=\"_ _2b2\">,824\u2009\u00b9</span><span class=\"_ _76\"> </span><span class=\"ws0\">760p to 817p<span class=\"_ _10a\"> </span>26/06/2023 to 05/10/2023<span class=\"_ _156\"> </span>26/06/2030 to 05/10/2030<span class=\"_ _2b2\"> </span></span></span>1,122,382<span class=\"_ _262\"> </span><span class=\"ff9\">1,281,133<span class=\"_ _2b2\"> </span></span>\u00b9 <span class=\"_ _5d\"> </span> <span class=\"_ _1e\"></span>Options granted under the 2015 Executive share option scheme.<span class=\"_ _2b2\"> </span>Options granted to employees under the Oxford Biomedica 2015 Sharesave scheme<span class=\"ls1\"> </span>2022 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>Number of shares<span class=\"_ _2b2\"> </span>2021 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>Number of shares<span class=\"_ _2b2\"> </span>Exercise price <span class=\"_ _32\"></span><span class=\"ls1\"> </span>per share<span class=\"_ _2b2\"> </span>Date from <span class=\"_ _32\"></span><span class=\"ls1\"> </span>which exercisable<span class=\"_ _1b\"> </span>Expiry date<span class=\"_ _2b2\"> </span>\u2013<span class=\"_ _20\"> </span><span class=\"ff9 lsa wsa\">29<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>682<span class=\"_ _19\"> </span>725p<span class=\"_ _f6\"> </span>10/10/21<span class=\"_ _24\"> </span>10/04/22<span class=\"_ _2b2\"> </span></span>187<span class=\"_ _3\"></span>,396<span class=\"_ _122\"> </span><span class=\"ff9\">237<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>069<span class=\"_ _128\"> </span>422p<span class=\"_ _24\"> </span>09/10/22<span class=\"_ _110\"> </span>09/04/23<span class=\"_ _2b2\"> </span></span>98,670<span class=\"_ _261\"> </span><span class=\"ff9\">154,<span class=\"_ _25\"></span>756<span class=\"_ _67\"> </span>672p<span class=\"_ _f6\"> </span>31/10/23<span class=\"_ _16d\"> </span>30/04/24<span class=\"_ _2b2\"> </span></span>71,109<span class=\"_ _11c\"> </span><span class=\"ff9\">143,345<span class=\"_ _105\"> </span>1,226p<span class=\"_ _175\"> </span>31/10/24<span class=\"_ _110\"> </span>30/04/25<span class=\"_ _2b2\"> </span></span>623,097<span class=\"_ _68\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _120\"> </span></span><span class=\"ff9\">294p<span class=\"_ _f6\"> </span>19/10/25<span class=\"_ _172\"> </span>19/04/26<span class=\"_ _2b2\"> </span></span>980,272<span class=\"_ _124\"> </span><span class=\"ff9\">564,<span class=\"_ _25\"></span>852<span class=\"_ _2b2\"> </span></span>Options granted under the Oxford Biomedica 2007 and 2015 Long T<span class=\"_ _3\"></span>erm Incentive Plans<span class=\"ls1\"> </span>2022 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>Number of shares<span class=\"_ _2b2\"> </span>2021 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span>Number of shares<span class=\"_ _2b2\"> </span>Exercise price <span class=\"_ _32\"></span><span class=\"ls1\"> </span>per share<span class=\"_ _2b2\"> </span>Date from <span class=\"_ _32\"></span><span class=\"ls1\"> </span>which exercisable<span class=\"_ _1b\"> </span>Expiry date<span class=\"_ _2b2\"> </span>55,77<span class=\"_ _25\"></span>4<span class=\"_ _115\"> </span><span class=\"ff9\">55,77<span class=\"_ _25\"></span>4<span class=\"_ _24\"> </span>50p<span class=\"_ _21\"> </span>Vested<span class=\"_ _105\"> </span>12/06/2023<span class=\"_ _2b2\"> </span></span>29,52<span class=\"_ _25\"></span>4<span class=\"_ _263\"> </span><span class=\"ff9\">29<span class=\"_ _25\"></span>,524<span class=\"_ _24\"> </span>50p<span class=\"_ _21\"> </span>Vested<span class=\"_ _103\"> </span><span class=\"ws0\">20/06/2024 to 17/10/202<span class=\"_ _25\"></span>4<span class=\"_ _2b2\"> </span></span></span>43,824<span class=\"_ _20\"> </span><span class=\"ff9\">43<span class=\"_ _25\"></span>,824<span class=\"_ _231\"> </span>0p<span class=\"_ _21\"> </span>Vested<span class=\"_ _2b\"> </span>10/01/2025<span class=\"_ _2b2\"> </span></span>82,185<span class=\"_ _263\"> </span><span class=\"ff9\">82,185<span class=\"_ _fd\"> </span>0p<span class=\"_ _21\"> </span>Vested<span class=\"_ _105\"> </span>16/05/2026<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">123,754\u2009\u00b2</span><span class=\"_ _60\"> </span><span class=\"ff9\"><span class=\"_ _2b2\">143,294\u2009\u00b2</span><span class=\"_ _fd\"> </span>0p<span class=\"_ _21\"> </span>Vested<span class=\"_ _264\"> </span><span class=\"ws0\">17/07/2027 to 25/09/2027<span class=\"_ _2b2\"> </span></span></span>39,<span class=\"_ _25\"></span><span class=\"_ _2b2\">652\u2009\u00b2</span><span class=\"_ _104\"> </span><span class=\"ff9\"><span class=\"_ _2b2\">62,913\u2009\u00b9<span class=\"_ _2b2\"> </span></span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _231\"> </span><span class=\"lsa wsa\">0p<span class=\"_ _d9\"> </span>V<span class=\"_ _25\"></span>ested<span class=\"_ _158\"> </span><span class=\"ws0\">15/02/2028 to 07/08/2028<span class=\"_ _2b2\"> </span></span></span>109,<span class=\"_ _25\"></span><span class=\"_ _2b2\">658\u2009\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _14e\"> </span><span class=\"ff9 lsa wsa\">282,093\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _231\"> </span><span class=\"lsa wsa\">0p<span class=\"_ _d9\"> </span>V<span class=\"_ _25\"></span>ested<span class=\"_ _10a\"> </span><span class=\"ws0\">18/04/2029 to 12/09/2029<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">260,577\u2009\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _265\"> </span><span class=\"ff9 lsa wsa\">260,577\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _231\"> </span><span class=\"lsa wsa\">0p<span class=\"_ _263\"> </span>26/06/2023<span class=\"_ _fc\"> </span>26/06/2030<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">263,297\u2009\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _50\"> </span><span class=\"ff9 lsa wsa\">263,297\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _231\"> </span><span class=\"lsa wsa\">0p<span class=\"_ _266\"> </span>08/06/2024<span class=\"_ _20\"> </span>08/06/2031<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">205,562\u2009\u00b3</span><span class=\"_ _267\"> </span><span class=\"ff9\">234,<span class=\"_ _25\"></span>883\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _231\"> </span><span class=\"lsa wsa\">0p<span class=\"_ _266\"> </span>08/06/2024<span class=\"_ _20\"> </span>08/06/2031<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">460,986\u2009\u00b9<span class=\"_ _2b2\"> </span></span>,<span class=\"_ _2b2\"> </span>\u00b2<span class=\"_ _68\"> </span><span class=\"ff9\">\u2013<span class=\"_ _231\"> </span><span class=\"lsa wsa\">0p<span class=\"_ _263\"> </span>29/04/2025<span class=\"_ _20\"> </span>29/04/2032<span class=\"_ _2b2\"> </span></span></span><span class=\"_ _2b2\">1,403,889\u2009\u00b3</span><span class=\"_ _68\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _231\"> </span></span><span class=\"ff9\">0p<span class=\"_ _2\"></span> <span class=\"_ _164\"> </span><span class=\"ws0\">10/09/2022 to 20/12/2026<span class=\"_ _155\"> </span>18/03/2032 to 20/12/2032<span class=\"_ _2b2\"> </span></span></span>3,078,<span class=\"_ _25\"></span>692<span class=\"_ _58\"> </span><span class=\"ff9\">1,590<span class=\"_ _25\"></span>,364<span class=\"_ _2b2\"> </span></span>5,181,346<span class=\"_ _268\"> </span><span class=\"ff9\">3,<span class=\"_ _3\"></span>436,268<span class=\"_ _2b2\"> </span></span>\u00b9 <span class=\"_ _5d\"> </span> <span class=\"_ _1e\"></span>These L<span class=\"_ _25\"></span>TIP awards will vest provided that performance conditions speci\ufb01ed in the Dir<span class=\"_ _25\"></span>ectors\u2019 Remuneration Report are met.<span class=\"_ _2b2\"> </span>\u00b2 <span class=\"_ _5d\"> </span> <span class=\"_ _1e\"></span>Options granted under the 2015 L<span class=\"_ _25\"></span>TIP<span class=\"_ _27\"></span>.<span class=\"_ _2b2\"> </span>\u00b3 <span class=\"_ _5d\"> </span> <span class=\"_ _1e\"></span>Restricted Share Options (RSUs) granted under the 2015 L<span class=\"_ _3\"></span>TIP issued to employees vesting over 3 years<span class=\"_ _2b2\"> </span>.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs779\">Deferred Share Awards<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs77a\">The Executive Directors and certain other senior managers have been awarded deferr<span class=\"_ _25\"></span>ed bonuses in the form of share options. These </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs77b\">options are exercisable at nil p on either the \ufb01rst three anniversaries o<span class=\"_ _25\"></span>f the grant or the third anniversary of the grant dependent on the </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs77c\">option conditions. Options with a value of \u00a31,029<span class=\"_ _3\"></span>,000 vested during 2022 (2021: \u00a31,037<span class=\"_ _27\"></span>,000).<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs77d\">The options granted under the 2013 Deferred Bonus Plan will be satis\ufb01ed by market-purchased shar<span class=\"_ _25\"></span>es held by the Oxford Biomedica </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs77e\">Employee Bene\ufb01t T<span class=\"_ _27\"></span><span class=\"_ _2b2\">rust (EBT). As at 31 December 2022, all shares held by the EBT had vested. The EBT is consolidated at year end with </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs77f\">the shares held in trust until the exercise of the option. During the year 77<span class=\"_ _27\"></span>,376 shares (2021: nil) from the EBT were exercised. Deferred </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs780\">bonus share awards are valued at the market price on the da<span class=\"_ _25\"></span>te of grant.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs781\">The options granted under the 2015 Deferred Bonus Plan will be satis\ufb01ed by new issue shares at the time of ex<span class=\"_ _25\"></span>ercise.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs782\">Options granted to employees under the Oxford Biomedica 2013 and 2015 Deferred Bonus Plan<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs783\">2022 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs784\">Number of shares<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs785\">2021 <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs786\">Number of shares<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs787\">Exercise price <span class=\"_ _32\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs788\">per share<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs789\">Date from <span class=\"_ _32\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs78a\">which exercisable<span class=\"_ _1b\"> </span>Expiry date<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs78b\">68,725<span class=\"_ _263\"> </span><span class=\"ff9\">68,<span class=\"_ _25\"></span>725<span class=\"_ _fd\"> </span>0p<span class=\"_ _1c\"> </span>Exercisable<span class=\"_ _15a\"> </span><span class=\"ws0\">15/06/24 and 14/10/2<span class=\"_ _25\"></span>4<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs78c\">27<span class=\"_ _3\"></span>,402<span class=\"_ _105\"> </span><span class=\"ff9\">27<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>402<span class=\"_ _fd\"> </span>0p<span class=\"_ _1c\"> </span>Exercisable<span class=\"_ _16d\"> </span>04/05/25<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs78d\">32,010<span class=\"_ _263\"> </span><span class=\"ff9\">32,<span class=\"_ _25\"></span>010<span class=\"_ _fd\"> </span>0p<span class=\"_ _1c\"> </span>Exercisable<span class=\"_ _24\"> </span>14/05/26<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs78e\">27<span class=\"_ _3\"></span>,696<span class=\"_ _105\"> </span><span class=\"ff9\">27<span class=\"_ _3\"></span>,696<span class=\"_ _231\"> </span>0p<span class=\"_ _1c\"> </span>Exercisable<span class=\"_ _f5\"> </span>11<span class=\"_ _2\"></span>/07/27<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs78f\">31,815<span class=\"_ _266\"> </span><span class=\"ff9\">36,205<span class=\"_ _fd\"> </span>0p<span class=\"_ _1c\"> </span>Exercisable<span class=\"_ _110\"> </span>07/08/28<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs790\">67<span class=\"_ _3\"></span>,793<span class=\"_ _115\"> </span><span class=\"ff9\">67<span class=\"_ _25\"></span>,793<span class=\"_ _231\"> </span>0p<span class=\"_ _1c\"> </span>Exercisable<span class=\"_ _172\"> </span>18/04/29<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs791\">64,701<span class=\"_ _263\"> </span><span class=\"ff9\">65<span class=\"_ _25\"></span>,576<span class=\"_ _fd\"> </span>0p<span class=\"_ _100\"> </span><span class=\"ws0\">20/06/21 to 20/06/23<span class=\"_ _110\"> </span></span>20/06/30<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs792\">58,943<span class=\"_ _266\"> </span><span class=\"ff9\">58,943<span class=\"_ _231\"> </span>0p<span class=\"_ _23c\"> </span><span class=\"ws0\">08/06/22 to 08/06/24<span class=\"_ _172\"> </span></span>20/06/31<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs793\">175,958<span class=\"_ _68\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _231\"> </span></span><span class=\"ff9\">0p<span class=\"_ _5e\"> </span><span class=\"ws0\">29/04/23 to 29/04/25<span class=\"_ _16c\"> </span></span>29/04/32<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs794\">555,043<span class=\"_ _121\"> </span><span class=\"ff9\">384,350<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs795\">National insurance liability<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs796\">Certain options granted to UK employees could give rise to a national insurance (NI) liability on exercise. A liability of \u00a3642,<span class=\"_ _25\"></span>000 (2021: </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs797\">\u00a31,305,<span class=\"_ _25\"></span><span class=\"_ _2b2\">000) is included in accruals for the potential NI liability accrued to 31 December on exercisable options that were above wa</span><span class=\"_ _25\"></span>ter </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs798\">based on the year-end share price o<span class=\"_ _25\"></span>f 443p (2021: 1,230p) per share.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs799\">28, Share based payments<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs79a\">Sharesave Scheme awards <span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs79b\">(Model used: Black Scholes)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs79c\">Options awarded <span class=\"_ _1e\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs79d\">19 Oct 2022<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs79e\">Share price at grant date<span class=\"_ _1dd\"> </span><span class=\"wsa\">300.<span class=\"_ _25\"></span>00p<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs79f\">Exercise price<span class=\"_ _1d6\"> </span><span class=\"wsa\">294.<span class=\"_ _3\"></span>40p<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a0\">Vesting period (years)<span class=\"_ _269\"> </span><span class=\"ls1\">3<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a1\">T<span class=\"_ _27\"></span>otal number of shares under option<span class=\"_ _1fb\"> </span><span class=\"wsa\">626,154<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a2\">Expected volatility (weighted average)<span class=\"_ _1d8\"> </span><span class=\"wsa\">48.<span class=\"_ _25\"></span>08%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a3\">Expected life (years)<span class=\"_ _26a\"> </span><span class=\"ls1\">3<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a4\">Risk free rate (weighted average)<span class=\"_ _26b\"> </span><span class=\"wsa\">3.<span class=\"_ _3\"></span>49%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a5\">Fair value per option<span class=\"_ _26c\"> </span><span class=\"wsa\">109<span class=\"_ _25\"></span>.61p<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs7a6\">L<span class=\"_ _3\"></span>TIP awards<span class=\"_ _2\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a7\">(Model used: Monte Carlo)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a8\">L<span class=\"_ _3\"></span>TIPs awarded<span class=\"_ _2\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7a9\">29 Apr 2022<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7aa\">L<span class=\"_ _3\"></span>TIPs awarded<span class=\"_ _2\"></span> <span class=\"_ _2f\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7ab\">18 Mar 2022<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7ac\">Share price at grant date<span class=\"_ _26d\"> </span><span class=\"wsa\">570p<span class=\"_ _af\"> </span>697p<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7ad\">Exercise price<span class=\"_ _26e\"> </span><span class=\"wsa\">0p<span class=\"_ _76\"> </span>0p<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7ae\">Vesting period (years)<span class=\"_ _205\"> </span><span class=\"ls1\">3<span class=\"_ _59\"> </span>3<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7af\">T<span class=\"_ _27\"></span>otal number of shares under option<span class=\"_ _26f\"> </span><span class=\"wsa\">474<span class=\"_ _25\"></span>,117<span class=\"_ _1e0\"> </span>268,790<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7b0\">Expected volatility (weighted average)<span class=\"_ _270\"> </span><span class=\"wsa\">46.<span class=\"_ _25\"></span>03%<span class=\"_ _15a\"> </span>44.78%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7b1\">Expected life (years)<span class=\"_ _271\"> </span><span class=\"ls1\">3<span class=\"_ _13e\"> </span>3<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7b2\">Risk free rate (weighted average)<span class=\"_ _272\"> </span><span class=\"wsa\">1.65%<span class=\"_ _d7\"> </span>0.21%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs7b3\">Fair value per option<span class=\"_ _273\"> </span><span class=\"wsa\">278p<span class=\"_ _20f\"> </span>475p<span class=\"_ _2b2\"> </span></span></div>The tables below show the movements in the Share Option Scheme, Sharesave scheme and the L<span class=\"_ _27\"></span>TIP during the year, together with the<span class=\"_ _2b2\"> </span>related weighted average exercise prices.<span class=\"_ _2b2\"> </span>Excluding the L<span class=\"_ _3\"></span>TIP<span class=\"_ _27\"></span>, RSU and Deferred Bonus awards which are exercisable at par/nil value, the weighted average ex<span class=\"_ _25\"></span>ercise price for options<span class=\"_ _2b2\"> </span>granted during the year was 294.<span class=\"_ _27\"></span>4p (2021: 1,226.0p).<span class=\"_ _2b2\"> </span>290,<span class=\"_ _25\"></span>022 options were exer<span class=\"_ _25\"></span>cised in 2022 (2021: 471,520), including 4,390 of deferr<span class=\"_ _25\"></span>ed bonus options (2021: 69<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>454). The total charge for<span class=\"_ _2\"></span> the year relating to employee share-based payment plans was \u00a36,<span class=\"_ _27\"></span>471,000 (2021: \u00a33,523,<span class=\"_ _25\"></span>000), all of which related to equity-settled shar<span class=\"_ _25\"></span>e<span class=\"_ _2b2\"> </span>based payment transactions.<span class=\"_ _2b2\"> </span>2022<span class=\"_ _20d\"> </span>2021<span class=\"_ _2b2\"> </span>Share options<span class=\"ls1\"> </span>excluding L<span class=\"_ _3\"></span>TIP<span class=\"_ _274\"> </span><span class=\"wsa\">Number<span class=\"_ _2b2\"> </span></span>Weighted average<span class=\"ls1\"> </span>exercise price<span class=\"_ _111\"> </span><span class=\"ff9 wsa\">Number<span class=\"_ _2b2\"> </span></span>Weighted average<span class=\"ls1\"> </span>exercise price<span class=\"_ _2b2\"> </span>Outstanding at 1 January<span class=\"_ _12\"> </span><span class=\"ffa wsa\">1,845,<span class=\"_ _25\"></span>904<span class=\"_ _fc\"> </span>695.5p<span class=\"_ _101\"> </span><span class=\"ff9\">2,118<span class=\"_ _25\"></span>,041<span class=\"_ _20\"> </span>548.7p<span class=\"_ _2b2\"> </span></span></span>Granted<span class=\"_ _b5\"> </span><span class=\"ffa\">626,154<span class=\"_ _78\"> </span>294.<span class=\"_ _25\"></span>4p<span class=\"_ _11c\"> </span><span class=\"ff9\">144<span class=\"_ _25\"></span>,079<span class=\"_ _104\"> </span>1,226.0p<span class=\"_ _2b2\"> </span></span></span>Forfeited<span class=\"_ _d2\"> </span><span class=\"ffa\">(182,828)<span class=\"_ _20\"> </span>718.5p<span class=\"_ _60\"> </span></span>(1<span class=\"_ _25\"></span>47<span class=\"_ _3\"></span>,282)<span class=\"_ _263\"> </span>706<span class=\"_ _25\"></span>.<span class=\"_ _3\"></span>4p<span class=\"_ _2b2\"> </span>Exercised<span class=\"_ _275\"> </span><span class=\"ffa\">(19,195)<span class=\"_ _fc\"> </span>467<span class=\"_ _3\"></span>.0p<span class=\"_ _101\"> </span><span class=\"ff9\">(252,676)<span class=\"_ _2b\"> </span>577<span class=\"_ _27\"></span>.5p<span class=\"_ _2b2\"> </span></span></span>Cancelled<span class=\"_ _119\"> </span><span class=\"ffa\">(167<span class=\"_ _3\"></span>,381)<span class=\"_ _fc\"> </span>829<span class=\"_ _25\"></span>.9p<span class=\"_ _122\"> </span><span class=\"ff9\">(16,258)<span class=\"_ _115\"> </span>587<span class=\"_ _25\"></span>.7p<span class=\"_ _2b2\"> </span></span></span>Outstanding at 31 December<span class=\"_ _265\"> </span><span class=\"ffa wsa\">2,102,654<span class=\"_ _266\"> </span>565.3p<span class=\"_ _265\"> </span><span class=\"ff9\">1,845,904<span class=\"_ _266\"> </span>695.5p<span class=\"_ _2b2\"> </span></span></span>Exercisable at 31 December<span class=\"_ _266\"> </span><span class=\"ffa wsa\">524,463<span class=\"_ _78\"> </span>520.0p<span class=\"_ _11c\"> </span><span class=\"ff9\">410,102<span class=\"_ _266\"> </span>588.<span class=\"_ _3\"></span>4p<span class=\"_ _2b2\"> </span></span></span>Exercisable and where<span class=\"_ _2b2\"> </span>market price exceeds<span class=\"_ _2b2\"> </span>exercise price<span class=\"ls1\"> </span>at 31 December<span class=\"_ _a6\"> </span><span class=\"ffa wsa\">269,463<span class=\"_ _78\"> </span>520.<span class=\"_ _25\"></span>0p<span class=\"_ _11c\"> </span><span class=\"ff9\">410,102<span class=\"_ _266\"> </span>588.<span class=\"_ _25\"></span>4p<span class=\"_ _2b2\"> </span></span></span>L<span class=\"fs5 lsa\">TIP awards (options ex<span class=\"_ _25\"></span>ercisable at par value 1p or nil cost)<span class=\"_ _276\"> </span>2022 Number<span class=\"_ _ce\"> </span><span class=\"ff9\">2021 Number<span class=\"_ _2b2\"> </span></span></span>Outstanding at 1 January<span class=\"_ _1e7\"> </span><span class=\"ffa wsa\">1,590,364<span class=\"_ _c5\"> </span><span class=\"ff9\">1,361,829<span class=\"_ _2b2\"> </span></span></span>Granted<span class=\"_ _13a\"> </span><span class=\"ffa\">2,053,897<span class=\"_ _b9\"> </span></span>507<span class=\"_ _27\"></span>,604<span class=\"_ _2b2\"> </span>Expired<span class=\"_ _277\"> </span><span class=\"ffa\">(299,132)<span class=\"_ _154\"> </span></span>(168,796)<span class=\"_ _2b2\"> </span>Exercised<span class=\"_ _278\"> </span><span class=\"ffa\">(266,437)<span class=\"_ _56\"> </span></span>(110,273)<span class=\"_ _2b2\"> </span>Outstanding at 31 December<span class=\"_ _279\"> </span><span class=\"ffa\"> 3,078,<span class=\"_ _25\"></span>692 <span class=\"_ _257\"> </span><span class=\"ff9 wsa\">1,590,364<span class=\"_ _2b2\"> </span></span></span>Exercisable at 31 December<span class=\"_ _27a\"> </span><span class=\"ffa wsa\">484,371<span class=\"_ _de\"> </span><span class=\"ff9\">549<span class=\"_ _25\"></span>,514<span class=\"_ _2b2\"> </span></span></span>Range of exercise prices<span class=\"_ _2b2\"> </span>Weighted<span class=\"ls1 ws0\"> </span>average<span class=\"ls1 ws0\"> </span>exercise price<span class=\"_ _2b2\"> </span>Number<span class=\"ls1 ws0\"> </span>of shares<span class=\"_ _2b2\"> </span>Weighted average<span class=\"_ _2b2\"> </span>remaining life<span class=\"_ _2b2\"> </span>(years)<span class=\"_ _2b2\"> </span>Weighted<span class=\"ls1 ws0\"> </span>average<span class=\"ls1 ws0\"> </span>exercise price<span class=\"_ _2b2\"> </span>Number<span class=\"ls1 ws0\"> </span>of shares<span class=\"_ _2b2\"> </span>Weighted average<span class=\"_ _2b2\"> </span>remaining life<span class=\"_ _2b2\"> </span>(years)<span class=\"_ _2b2\"> </span>L<span class=\"_ _3\"></span>TIP:<span class=\"_ _2b2\"> </span>Exercisable at par or at nil cost<span class=\"_ _153\"> </span><span class=\"ffa wsa\">1.4p<span class=\"_ _3d\"> </span>3,078,692<span class=\"_ _144\"> </span><span class=\"ls56 ws4d\">8.2<span class=\"_ _6e\"> </span></span></span><span class=\"ls3d ws34\">6.8p<span class=\"_ _16b\"> </span></span><span class=\"wsa\">1,590,364<span class=\"_ _88\"> </span><span class=\"ls47 ws3f\">6.9<span class=\"_ _2b2\"> </span></span></span>Deferred bonus:<span class=\"_ _2b2\"> </span>Exercisable at par or at nil cost<span class=\"_ _27b\"> </span><span class=\"ffa wsa\">0p<span class=\"_ _d0\"> </span>555,043<span class=\"_ _88\"> </span>6.5<span class=\"_ _76\"> </span><span class=\"ff9\">0p<span class=\"_ _1e0\"> </span>384,350<span class=\"_ _79\"> </span><span class=\"ls47 ws3f\">6.3<span class=\"_ _2b2\"> </span></span></span></span>Options:<span class=\"_ _2b2\"> </span>50p to 150p<span class=\"_ _f2\"> </span><span class=\"ffa wsa\">101p<span class=\"_ _e3\"> </span>21,822<span class=\"_ _144\"> </span><span class=\"ls3d ws34\">0.9<span class=\"_ _10\"> </span></span><span class=\"ff9\">101p<span class=\"_ _8c\"> </span>25,197<span class=\"_ _b1\"> </span><span class=\"ls3d ws34\">1.8<span class=\"_ _2b2\"> </span></span></span></span>150p to 250p<span class=\"_ _27c\"> </span><span class=\"ffa wsa\">200p<span class=\"_ _8d\"> </span>7<span class=\"_ _3\"></span>,556<span class=\"_ _79\"> </span><span class=\"ls2 ws3\">1.8<span class=\"_ _53\"> </span></span><span class=\"ff9\">183p<span class=\"_ _160\"> </span>12,036<span class=\"_ _b1\"> </span><span class=\"ls45 ws3d\">1.9<span class=\"_ _2b2\"> </span></span></span></span>250p to 350p<span class=\"_ _27c\"> </span><span class=\"ffa wsa\">293p<span class=\"_ _1e0\"> </span>675,786<span class=\"_ _88\"> </span><span class=\"ls42 ws3a\">9.<span class=\"_ _2\"></span>3<span class=\"_ _6c\"> </span></span><span class=\"ff9\">275p<span class=\"_ _e3\"> </span>56,228<span class=\"_ _88\"> </span><span class=\"ls40 ws38\">4.<span class=\"_ _2\"></span>3<span class=\"_ _2b2\"> </span></span></span></span>350p to 650p<span class=\"_ _aa\"> </span><span class=\"ffa wsa\">452p<span class=\"_ _cf\"> </span>321,493<span class=\"_ _88\"> </span><span class=\"ls3d ws34\">5.6<span class=\"_ _af\"> </span></span><span class=\"ff9\">454p<span class=\"_ _b9\"> </span>393,529<span class=\"_ _79\"> </span><span class=\"ls14 ws37\">6.7<span class=\"_ _2b2\"> </span></span></span></span>650p+<span class=\"_ _b2\"> </span><span class=\"ffa\">782p<span class=\"_ _166\"> </span>1,075,997<span class=\"_ _79\"> </span><span class=\"ls46 ws3e\">7.<span class=\"_ _2\"></span>0<span class=\"_ _6c\"> </span></span></span>798p<span class=\"_ _159\"> </span>1,358,914<span class=\"_ _b1\"> </span><span class=\"ls3d ws34\">8.1<span class=\"_ _2b2\"> </span></span>At 31 December 2021<span class=\"_ _1ae\"> </span><span class=\"ls1\"> <span class=\"_ _162\"> </span></span> 5,736,389<span class=\"_ _256\"> </span><span class=\"ff9 wsa\">3<span class=\"_ _25\"></span>,820<span class=\"_ _25\"></span>,618<span class=\"_ _2b2\"> </span></span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs7f2\">29<span class=\"_ _25\"></span>, Accumulated losses<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs7f3\">Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h2 ffa fs0 fc3 sc0 ls0 ws27 gs7f4\">Notes </div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs7f5\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs7f6\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs7f7\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs7f8\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs7f9\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs7fa\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs7fb\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs7fc\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs7fd\">At 1 January<span class=\"_ _19e\"> </span><span class=\"ffa wsa\">(165,806)<span class=\"_ _108\"> </span><span class=\"ff9\">(188,<span class=\"_ _25\"></span>723)<span class=\"_ _c4\"> </span><span class=\"ffa\">(128,584)<span class=\"_ _56\"> </span></span>(126,1<span class=\"_ _25\"></span>43)<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs7fe\">(Loss)/pro\ufb01t for the year<span class=\"_ _25e\"> </span><span class=\"ffa wsa\">(39,157)<span class=\"_ _100\"> </span><span class=\"ff9\">19,<span class=\"_ _25\"></span>011<span class=\"_ _55\"> </span><span class=\"ffa\">(4,804)<span class=\"_ _15b\"> </span></span>(2,366)<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs7ff\">Share based payments<span class=\"_ _241\"> </span><span class=\"ffa wsa\">5,<span class=\"_ _25\"></span>922<span class=\"_ _8d\"> </span><span class=\"ff9\">3,523<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs800\">Acquisition of NCI without a change in control<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs0 fc3 sc0 ls0 ws27 gs801\">37<span class=\"_ _75\"> </span><span class=\"ffa fs5 lsa wsa\">400<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ffa\">\u2013<span class=\"_ _7f\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs802\">Deferred tax on share options<span class=\"_ _27d\"> </span><span class=\"ffa wsa\">125<span class=\"_ _72\"> </span><span class=\"ff9\">458<span class=\"_ _7f\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs803\">Exercise of nil cost option<span class=\"_ _254\"> </span><span class=\"ffa wsa\">(29)<span class=\"_ _81\"> </span><span class=\"ff9\">(75)<span class=\"_ _82\"> </span></span>(15)<span class=\"_ _82\"> </span><span class=\"ff9\">(75)<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs804\">At 31 December<span class=\"_ _27e\"> </span><span class=\"wsa\">(198,545)<span class=\"_ _27f\"> </span><span class=\"ff9\">(165,806)<span class=\"_ _c4\"> </span></span>(133,403)<span class=\"_ _154\"> </span><span class=\"ff9\">(128,584)<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs805\">\u00b9 <span class=\"_ _5d\"> </span> <span class=\"_ _1e\"></span>The credit to accumulated losses is made up out of the charge for the year relating to employee share-based payment plans of \u00a35<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>442,000 (2021: \u00a32,<span class=\"_ _3\"></span>486,000) (note 28), </div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs806\">\u00a31,029<span class=\"_ _25\"></span>,000 (2021: \u00a31,<span class=\"_ _25\"></span>037<span class=\"_ _3\"></span>,000) related to the vesting of deferred share awards made to ex<span class=\"_ _25\"></span>ecutive directors and senior managers less \u00a3549<span class=\"_ _25\"></span>,000 of share based payment </div><div class=\"t m1 h8 ff9 fs0 fc3 sc0 ls1 ws0 gs807\">charge allocated to Non controlling interests.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs808\"><span class=\"_ _2b2\">Neither the Company nor its subsidiary undertakings had reserves available for distribution at 31 December 2022 or 31 December 2021.<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs809\">30, Other reserves<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs80a\">Group<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs80b\">T<span class=\"_ _27\"></span>ranslation<span class=\"_ _2\"></span> </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs80c\">Reserve <span class=\"_ _32\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs80d\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs80e\">Other equity </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs80f\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs810\">Merger reserve </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs811\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs812\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs813\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs814\">At 1 January 2022<span class=\"_ _1be\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _6b\"> </span></span><span class=\"wsa\">2,291<span class=\"_ _38\"> </span>2,291<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs815\">Put option recognition<span class=\"_ _1a2\"> </span><span class=\"ls1\">\u2013<span class=\"_ _1e0\"> </span></span><span class=\"wsa\">(38,996)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _1e0\"> </span></span><span class=\"wsa\">(38,996)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs816\">Put option revaluation<span class=\"_ _218\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">3,993<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7c\"> </span></span><span class=\"wsa\">3,<span class=\"_ _25\"></span>993<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs817\"><span class=\"_ _2b2\">Foreign currency translation differences</span><span class=\"_ _280\"> </span><span class=\"wsa\">7<span class=\"_ _3\"></span>,825<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _6b\"> </span></span>7<span class=\"_ _25\"></span>,825<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs818\">At 31 December 2022<span class=\"_ _281\"> </span><span class=\"wsa\">7<span class=\"_ _3\"></span>,825<span class=\"_ _d0\"> </span>(35,003)<span class=\"_ _7c\"> </span>2,291<span class=\"_ _134\"> </span><span class=\"ws0\"> (24<span class=\"_ _25\"></span>,887)<span class=\"_ _2b2\"> </span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs819\">Group<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs81a\">Merger reserve </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs81b\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs81c\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs81d\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs81e\">At 1 January 2022<span class=\"_ _282\"> </span><span class=\"wsa\">2,291<span class=\"_ _38\"> </span>2,291<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs81f\"><span class=\"_ _2b2\">At 31 December 2022</span><span class=\"_ _283\"> </span><span class=\"wsa\">2,291<span class=\"_ _7c\"> </span>2,291<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs820\">At 1 January 2021<span class=\"_ _284\"> </span><span class=\"wsa\">2,291<span class=\"_ _38\"> </span>2,291<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs821\"><span class=\"_ _2b2\">At 31 December 2021</span><span class=\"_ _ba\"> </span><span class=\"wsa\">2,291<span class=\"_ _7c\"> </span>2,291<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs822\">Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs823\">Merger reserve </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs824\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs825\">Share Scheme </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs826\">Reserve<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs827\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs828\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs829\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs82a\">At 1 January 2022<span class=\"_ _10f\"> </span><span class=\"wsa\">1,580<span class=\"_ _160\"> </span>18,792<span class=\"_ _e3\"> </span>20,372<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs82b\">Credit in relation to employee share schemes<span class=\"_ _1c1\"> </span><span class=\"ls1\">\u2013<span class=\"_ _85\"> </span></span><span class=\"wsa\">6,<span class=\"_ _25\"></span>471<span class=\"_ _85\"> </span>6,<span class=\"_ _3\"></span>471<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs82c\"><span class=\"_ _2b2\">At 31 December 2022</span><span class=\"_ _1f9\"> </span><span class=\"wsa\">1,580<span class=\"_ _12b\"> </span>25,263<span class=\"_ _15a\"> </span>26,843<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs82d\">At 1 January 2021<span class=\"_ _19b\"> </span><span class=\"wsa\">1,580<span class=\"_ _15e\"> </span>15,269<span class=\"_ _15e\"> </span>16,849<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs82e\">Credit in relation to employee share schemes<span class=\"_ _1c1\"> </span><span class=\"ls1\">\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">3,523<span class=\"_ _38\"> </span>3,523<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs82f\"><span class=\"_ _2b2\">At 31 December 2021</span><span class=\"_ _285\"> </span><span class=\"wsa\">1,580<span class=\"_ _e3\"> </span>18,792<span class=\"_ _12b\"> </span>20,372<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs830\">Merger reserve<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs831\"><span class=\"_ _2b2\">The Group merger reserve at 31 December 2022 and 2021 comprised \u00a3711,</span><span class=\"_ _25\"></span>000 arising from the consolidation of Oxford Biomedica (UK) </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs832\">Ltd using the merger method of accounting in 1996, and \u00a31,580<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>000 from the application of merger relief to the purchase o<span class=\"_ _25\"></span>f Oxxon </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs833\">Therapeutics Limited in 2007<span class=\"_ _3\"></span>.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs834\">Share scheme reserve<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs835\">Options over the Company\u2019s shares have been awarded to employees of Oxford Biomedica (UK) Ltd., Oxf<span class=\"_ _25\"></span>ord Biomedica Solutions and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs836\"><span class=\"_ _2b2\">Oxford Biomedica (US) Inc. In accordance with IFRS 2 </span></div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs837\">\u2019Share-based Payment\u2019 the expense in respect of these awards is recognised </div><div class=\"t m2 h7 ff9 fs4 fc3 sc0 lse ws0 gs838\">in the subsidiaries\u2019 \ufb01nancial statements (see note 27). </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs839\"><span class=\"_ _2b2\">In accordance with IFRS 2, the Company has treated the awards as a capital </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs83a\">contribution to the subsidiaries, resulting in an increase in the cost of investment of \u00a36<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>471,000 (2021: \u00a33,523,<span class=\"_ _25\"></span>000) (see note 1<span class=\"_ _25\"></span>4) and <span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs83b\">a corresponding credit to reserves.<span class=\"_ _2b2\"> </span></div>31, Cash \ufb02ows from operating activities<span class=\"_ _2b2\"> </span>Reconciliation of loss before tax to net cash used in operations:<span class=\"_ _2b2\"> </span>Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Continuing operations<span class=\"_ _2b2\"> </span>(Loss)/pro\ufb01t before taxation<span class=\"_ _286\"> </span><span class=\"ffa wsa\">(45,976)<span class=\"_ _e3\"> </span><span class=\"ff9\">19<span class=\"_ _25\"></span>,880<span class=\"_ _55\"> </span><span class=\"ffa\">(4,804)<span class=\"_ _15b\"> </span></span>(2,366)<span class=\"_ _2b2\"> </span></span></span>Adjustment for:<span class=\"_ _2b2\"> </span>Depreciation<span class=\"_ _242\"> </span><span class=\"ffa\">20,271<span class=\"_ _23c\"> </span></span>12,<span class=\"_ _25\"></span>435<span class=\"_ _72\"> </span><span class=\"ffa\">323<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span>Amortisation of intangible assets<span class=\"_ _213\"> </span><span class=\"ffa wsa\">6,<span class=\"_ _25\"></span>088<span class=\"_ _e2\"> </span><span class=\"ff9\">21<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Loss on disposal of property<span class=\"_ _25\"></span>, plant and equipment<span class=\"_ _1d\"> </span><span class=\"ffa wsa\">28<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span><span class=\"ffa\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span>(Gain) on sale and leaseback<span class=\"_ _287\"> </span><span class=\"ffa wsa\">(21,389)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span><span class=\"ffa\">\u2013<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span>Loss on disposal of intangible<span class=\"_ _17e\"> </span><span class=\"ffa wsa\">27<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span><span class=\"ffa\">\u2013<span class=\"_ _7f\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span>Amortisation of loan fees<span class=\"_ _7d\"> </span><span class=\"ffa wsa\">588<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _71\"> </span></span><span class=\"ffa wsa\">588<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Finance costs<span class=\"_ _288\"> </span><span class=\"ffa wsa\">15,756<span class=\"_ _6f\"> </span><span class=\"ff9\">888<span class=\"_ _e3\"> </span></span>1<span class=\"_ _25\"></span>4,033<span class=\"_ _7f\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span>Charge in relation to employee share schemes<span class=\"_ _289\"> </span><span class=\"ffa wsa\">6,471<span class=\"_ _38\"> </span><span class=\"ff9\">3,981<span class=\"_ _7f\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Non-cash loss<span class=\"_ _28a\"> </span><span class=\"ffa wsa\">51<span class=\"_ _81\"> </span><span class=\"ff9\">165<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Changes in working capital:<span class=\"_ _2b2\"> </span>(Increase)/decrease in trade and other receivables<span class=\"_ _28b\"> </span><span class=\"ffa wsa\">(17<span class=\"_ _3\"></span>,876)<span class=\"_ _38\"> </span><span class=\"ff9 ls5c ws71\">6,891<span class=\"_ _2c\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Increase/(decrease) in trade and other payables<span class=\"_ _25b\"> </span><span class=\"ffa wsa\">16,959<span class=\"_ _20f\"> </span><span class=\"ff9\">(657)<span class=\"_ _13e\"> </span></span><span class=\"ls1 ws0\">6<span class=\"_ _fb\"> </span></span><span class=\"ff9\">17<span class=\"_ _2b2\"> </span></span></span>Decrease in deferred income<span class=\"_ _28c\"> </span><span class=\"ffa wsa\">(691)<span class=\"_ _20f\"> </span><span class=\"ff9\">(867)<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span>Increase/(decrease)/ in contract liabilities<span class=\"_ _28d\"> </span><span class=\"ffa wsa\">5,852<span class=\"_ _109\"> </span><span class=\"ff9\">(15,<span class=\"_ _3\"></span>667)<span class=\"_ _9b\"> </span><span class=\"ffa ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></span>Decrease/(increase) in inventory<span class=\"_ _28e\"> </span><span class=\"ffa wsa\">688<span class=\"_ _15b\"> </span><span class=\"ff9\">(2,<span class=\"_ _25\"></span>609)<span class=\"_ _9b\"> </span><span class=\"ffa ls1 ws0\">\u2013<span class=\"_ _9b\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></span>Net cash (used in)/generated from operations<span class=\"_ _8\"> </span><span class=\"wsa\">(13,173)<span class=\"_ _8c\"> </span><span class=\"ff9\">24<span class=\"_ _25\"></span>,<span class=\"_ _3\"></span>461<span class=\"_ _e3\"> </span><span class=\"ffa\">10,1<span class=\"_ _25\"></span>46<span class=\"_ _e3\"> </span><span class=\"ff9\">(2,349)<span class=\"_ _2b2\"> </span></span></span></span></span>32, Pension commitments<span class=\"_ _2b2\"> </span>The Group operates a de\ufb01ned contribution pension scheme for its directors and employees. The assets of the scheme are held in<span class=\"_ _2b2\"> </span>independently administered funds. The pension cost charge of \u00a33,560<span class=\"_ _3\"></span>,000 (2021: \u00a32,839<span class=\"_ _25\"></span>,<span class=\"_ _25\"></span>000) represents amounts payable by the Group<span class=\"_ _2b2\"> </span>to the scheme. Contributions of \u00a3403,<span class=\"_ _25\"></span>000 (2021: \u00a3392,000), included in accruals, wer<span class=\"_ _25\"></span>e payable to the scheme at the year-end.<span class=\"_ _2b2\"> </span>33, Leases<span class=\"_ _2b2\"> </span>The additions to right of use assets during the year relate to lease of at Patriot\u2019s Park (\u00a325<span class=\"_ _25\"></span>.0 million) as part of the acquisition o<span class=\"_ _25\"></span>f Oxford<span class=\"_ _2b2\"> </span>Biomedica Solutions, and \u00a313.<span class=\"_ _25\"></span>0 million related to the new lease liabilities as a result of the sale and leaseback of the Windrush Court facility<span class=\"_ _2b2\"> </span>and the Wallingford W<span class=\"_ _25\"></span>arehouse.<span class=\"_ _2b2\"> </span>The additions in leases entered into during the year relate to those at Patriot\u2019s Park \u00a325<span class=\"_ _25\"></span><span class=\"_ _2b2\">.0 million r</span><span class=\"_ _25\"></span>espectively as part of the acquisition and<span class=\"_ _2b2\"> </span>\u00a339<span class=\"_ _25\"></span><span class=\"_ _2b2\">.2 million related to the new lease liabilities as a result of the sale and leaseback of the Windrush Court facility</span><span class=\"_ _25\"></span>, and the lease<span class=\"ls1\"> </span>of the Wallingford W<span class=\"_ _25\"></span>arehouse.<span class=\"_ _2b2\"> </span>Sale and leaseback of Windrush Court<span class=\"_ _2b2\"> </span>The Windrush Court building was owned and then sold by Oxford Biomedica (UK) Ltd in October 2022, after which the building was<span class=\"_ _2b2\"> </span>immediately leased under a 15 year lease by Oxford Biomedica PL<span class=\"_ _25\"></span>C on the same day<span class=\"_ _25\"></span>. In the Company\u2019s individual accounts, the Company<span class=\"_ _2b2\"> </span>has accounted for the lease as a standalone lease with the resultant lease liability and matching right of use asset, whilst Oxford Biomedica<span class=\"_ _2b2\"> </span>(UK) Ltd has accounted for the transaction as a standalone sale of an asset. However<span class=\"_ _25\"></span>, from a Group perspective the transaction has been<span class=\"_ _2b2\"> </span>accounted for as a sale and leaseback transaction as both companies form part of the same group and both the sale and leaseback was<span class=\"_ _2b2\"> </span>negotiated and entered into at the same time.<span class=\"_ _2b2\"> </span>The Group leases land and buildings and IT equipment. Information about leases for which the Group is a lessee is pr<span class=\"_ _25\"></span>esented below:<span class=\"_ _2b2\"> </span>Right-of-use assets:<span class=\"_ _2b2\"> </span>Group<span class=\"_ _27e\"> </span><span class=\"fs0 ls1 ws0\"> </span>Property<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Equipment<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>IT equipment<span class=\"ls1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Balance at 1 January 2022<span class=\"_ _7a\"> </span><span class=\"wsa\">11,<span class=\"_ _3\"></span>450<span class=\"_ _7c\"> </span>2,780<span class=\"_ _91\"> </span>36<span class=\"_ _160\"> </span>14<span class=\"_ _25\"></span>,266<span class=\"_ _2b2\"> </span></span>Acquisitions through business combinations<span class=\"_ _170\"> </span><span class=\"ls3f ws36\">24,9<span class=\"_ _2\"></span>74<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _15e\"> </span><span class=\"ls3f ws36\">24,9<span class=\"_ _2\"></span>74<span class=\"_ _2b2\"> </span></span></span>Foreign exchange<span class=\"_ _247\"> </span><span class=\"wsa\">2,072<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _8d\"> </span></span><span class=\"wsa\">2,072<span class=\"_ _2b2\"> </span></span>Additions<span class=\"_ _28f\"> </span>13,<span class=\"_ _25\"></span>038<span class=\"_ _9b\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _160\"> </span></span>13,<span class=\"_ _25\"></span>038<span class=\"_ _2b2\"> </span>Change in estimate<span class=\"_ _27e\"> </span><span class=\"wsa\">(1,349)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _160\"> </span></span><span class=\"wsa\">(1,349)<span class=\"_ _2b2\"> </span></span>Depreciation charge for the period<span class=\"_ _d3\"> </span><span class=\"wsa\">(4,185)<span class=\"_ _af\"> </span>(730)<span class=\"_ _82\"> </span>(36)<span class=\"_ _160\"> </span>(4,951)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">Balance at 31 December 2022</span><span class=\"_ _23d\"> </span><span class=\"wsa\">46,000<span class=\"_ _d7\"> </span>2,050<span class=\"_ _13e\"> </span></span><span class=\"ls1\">0<span class=\"_ _55\"> </span></span><span class=\"wsa\">48,050<span class=\"_ _2b2\"> </span></span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs882\">Company<span class=\"_ _290\"> </span><span class=\"fs0 ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs883\">Property<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs884\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs885\">Equipment<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs886\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs887\">IT equipment<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs888\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs889\">T<span class=\"_ _27\"></span>otal<span class=\"_ _2\"></span><span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs88a\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs88b\">Balance at 1 January 2022<span class=\"_ _281\"> </span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs88c\">Additions<span class=\"_ _23b\"> </span>39,717<span class=\"_ _7f\"> </span><span class=\"ls1 ws0\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _5e\"> </span></span>39<span class=\"_ _25\"></span>,717<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs88d\">Depreciation charge for the period<span class=\"_ _291\"> </span><span class=\"wsa\">(323)<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _7f\"> </span>\u2013<span class=\"_ _6c\"> </span></span><span class=\"wsa\">(323)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs88e\"><span class=\"_ _2b2\">Balance at 31 December 2022</span><span class=\"_ _292\"> </span><span class=\"wsa\">39,394<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _9b\"> </span>\u2013<span class=\"_ _15a\"> </span></span><span class=\"wsa\">39,394<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs88f\">Lease liabilities:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs890\">Group<span class=\"_ _1ac\"> </span>Company<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs891\">Maturity analysis \u2013 contractual undiscounted cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs892\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs893\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs894\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs895\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs896\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs897\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs898\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs899\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs89a\">Less than one year<span class=\"_ _1a8\"> </span><span class=\"ffa wsa\">9,179<span class=\"_ _8d\"> </span><span class=\"ff9\">1,590<span class=\"_ _d7\"> </span></span>3,500<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs89b\">One to \ufb01ve years<span class=\"_ _293\"> </span><span class=\"ffa wsa\">43,035<span class=\"_ _7c\"> </span><span class=\"ff9\">5,<span class=\"_ _25\"></span>883<span class=\"_ _12b\"> </span><span class=\"ffa\">13,300<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs89c\">Six to ten years<span class=\"_ _242\"> </span><span class=\"ffa wsa\">42,224<span class=\"_ _6b\"> </span><span class=\"ff9\">5,071<span class=\"_ _15b\"> </span></span>23,491<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs89d\">More than ten years <span class=\"_ _294\"> </span><span class=\"ffa wsa\">25,059<span class=\"_ _81\"> </span><span class=\"ff9\">913<span class=\"_ _12b\"> </span></span>22,935<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs89e\">T<span class=\"_ _3\"></span><span class=\"_ _2b2\">otal undiscounted cash \ufb02ows at 31 December 2022</span><span class=\"_ _295\"> </span><span class=\"wsa\">119,<span class=\"_ _25\"></span>497<span class=\"_ _10c\"> </span><span class=\"ff9\">13,<span class=\"_ _25\"></span>457<span class=\"_ _33\"> </span><span class=\"ffa\">63,226<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs89f\">Lease liabilities included in the Statement of Financial Position<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8a0\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8a1\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8a2\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8a3\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8a4\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8a5\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8a6\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8a7\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs8a8\">Current<span class=\"_ _296\"> </span><span class=\"ffa\">3,295<span class=\"_ _72\"> </span></span>853<span class=\"_ _71\"> </span><span class=\"ffa\">683<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs8a9\">Non-current<span class=\"_ _1b8\"> </span><span class=\"ffa\">71,206<span class=\"_ _da\"> </span></span>8,<span class=\"_ _3\"></span>488<span class=\"_ _33\"> </span><span class=\"ffa\">34,939<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs8aa\">T<span class=\"_ _3\"></span><span class=\"_ _2b2\">otal lease liabilities at 31 December 2021</span><span class=\"_ _1ca\"> </span><span class=\"wsa\">74,501<span class=\"_ _38\"> </span><span class=\"ff9\">9,341<span class=\"_ _12b\"> </span></span>35,622<span class=\"_ _9b\"> </span></span><span class=\"ff9 ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs8ab\">Amounts recognised in the pro\ufb01t or (loss)<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8ac\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8ad\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8ae\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8af\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8b0\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8b1\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8b2\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8b3\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs8b4\">Interest on lease liabilities<span class=\"_ _1c0\"> </span><span class=\"ffa wsa\">3,124<span class=\"_ _82\"> </span><span class=\"ff9\">873<span class=\"_ _72\"> </span></span>477<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs8b5\">Expense relating to short term leases<span class=\"_ _297\"> </span><span class=\"ffa wsa\">178<span class=\"_ _72\"> </span><span class=\"ff9\">369<span class=\"_ _9b\"> </span></span><span class=\"ls1 ws0\">\u2013<span class=\"_ _7f\"> </span><span class=\"ff9\">\u2013<span class=\"_ _2b2\"> </span></span></span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs8b6\">Amounts recognised in the statement of cash \ufb02ows<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8b7\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8b8\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8b9\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8ba\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8bb\">2022<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8bc\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8bd\">2021<span class=\"ls1 ws0\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8be\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs8bf\">T<span class=\"_ _3\"></span>otal cash out\ufb02ow for leases<span class=\"_ _182\"> </span><span class=\"wsa\">4,244<span class=\"_ _7c\"> </span><span class=\"ff9\">5,393<span class=\"_ _71\"> </span></span>422<span class=\"_ _9b\"> </span></span><span class=\"ff9 ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs8c0\">34, Contingent liabilities and capital commitments<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c1\">The Group has a letter of credit \u00a31,<span class=\"_ _3\"></span>405,<span class=\"_ _25\"></span>000 (2021: nil) related to the deposit on the Patriots park lease which is disclosed within T<span class=\"_ _27\"></span>rade and </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c2\">other receivables in non current assets. The Group had commitments of \u00a32,<span class=\"_ _25\"></span>882,000 for capital expenditur<span class=\"_ _25\"></span>e for leasehold improvements </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c3\"><span class=\"_ _2b2\">and plant and equipment not provided for in the \ufb01nancial statements at 31 December 2022 (2021: \u00a33</span><span class=\"_ _25\"></span>,97<span class=\"_ _25\"></span>4,<span class=\"_ _25\"></span>000).<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs8c4\">35, Acquisition of subsidiary<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c5\">On 10 March 2022, the Group acquired 7<span class=\"_ _25\"></span>4% of the shares and voting interests in Oxfor<span class=\"_ _25\"></span>d Biomedica Solutions LLC for US$130 million.<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c6\">As a result, the Group\u2019s equity interest granted it control of Oxf<span class=\"_ _25\"></span>ord Biomedica Solutions. Immediately following the acquisition, the Group </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c7\">acquired a further 6% interest in Oxford Biomedica Solutions through an equity investment of \u00a338<span class=\"_ _25\"></span>.2 million (US$50 million) leading to<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8c8\">a dilution in the interests of Homology Medicines from 26% to 20% (refer note 37).<span class=\"_ _2b2\"> </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8c9\">Included in the identi\ufb01able assets and liabilities acquired at the date of acquisition of Oxford Biomedica Solutions ar<span class=\"_ _25\"></span>e inputs, production </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8ca\">processes and an organised workforce. The Group has determined that together the acquir<span class=\"_ _25\"></span>ed inputs and processes signi\ufb01cantly contribute </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8cb\">to the Group\u2019s ability to create revenue. The Group has concluded tha<span class=\"_ _25\"></span>t the acquired inputs and processes is a business.</div>A. Consideration T<span class=\"_ _27\"></span>ransferred<span class=\"_ _2b2\"> </span>The following table summarises the acquisition date fair value of each major class of consideration transferred:<span class=\"_ _2b2\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Cash <span class=\"_ _298\"> </span>99<span class=\"_ _25\"></span>,206<span class=\"_ _2b2\"> </span>T<span class=\"_ _3\"></span>otal Consideration<span class=\"_ _299\"> </span><span class=\"wsa\">99,206<span class=\"_ _2b2\"> </span></span>B. Acquisition related expenses:<span class=\"_ _2b2\"> </span>The Group incurred acquisition related legal and due diligence expenses of \u00a35<span class=\"_ _25\"></span><span class=\"_ _2b2\">.1 million (2021: \u00a31.2 million) which is included in<span class=\"_ _2b2\"> </span></span>Administrative expenses.<span class=\"_ _2b2\"> </span>C. Identi\ufb01able assets acquired and liabilities assumed:<span class=\"_ _2b2\"> </span>The following table summarises the recognised amounts of assets acquired and liabilities assumed at the date of acquisition:<span class=\"_ _2b2\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Property<span class=\"_ _25\"></span>, plant &amp; equipment<span class=\"_ _26e\"> </span><span class=\"wsa\">58,945<span class=\"_ _2b2\"> </span></span>Intangible assets<span class=\"_ _1e5\"> </span><span class=\"wsa\">102,<span class=\"_ _25\"></span>869<span class=\"_ _2b2\"> </span></span>Inventory<span class=\"_ _29a\"> </span>3,<span class=\"_ _3\"></span>476<span class=\"_ _2b2\"> </span>Prepaid expenses<span class=\"_ _29b\"> </span><span class=\"wsa\">229<span class=\"_ _2b2\"> </span></span>Lease Liabilities<span class=\"_ _12c\"> </span><span class=\"wsa\">(24<span class=\"_ _25\"></span>,97<span class=\"_ _25\"></span>4)<span class=\"_ _2b2\"> </span></span>Deferred tax liabilities<span class=\"_ _29c\"> </span><span class=\"wsa\">(7<span class=\"_ _3\"></span>,307)<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _3\"></span>otal identi\ufb01able net assets acquired:<span class=\"_ _ba\"> </span><span class=\"wsa\">133,238<span class=\"_ _2b2\"> </span></span>The valuation techniques used for measuring the fair value of material assets acquired were as follows:<span class=\"_ _2b2\"> </span>Assets acquired<span class=\"_ _295\"> </span>Valuation technique<span class=\"_ _2b2\"> </span>Property plant and equipment<span class=\"_ _71\"> </span>Market comparison technique and cost technique \u2013 The valuation model considers market prices <span class=\"ls1\"> </span>for similar items when they are available, and depreciated replacement cost when appr<span class=\"_ _25\"></span>opriate. <span class=\"ls1\"> </span>Depreciated replacement cost re\ufb02ects adjustments for physical deterioration as well as functional<span class=\"_ _2b2\"> </span>and economic obsolescence<span class=\"ls1\"> </span>Intangible assets<span class=\"_ _29d\"> </span>Multi-period excess earnings method \u2013 The multi-period excess earnings method considers the<span class=\"_ _2b2\"> </span>present value of net cash \ufb02ows expected to be generated by the client relationships, by excluding<span class=\"ls1\"> </span>any cash \ufb02ows related to contributory assets.<span class=\"ls1\"> </span>Inventory<span class=\"_ _2b2\"> </span>Market comparison \u2013 T<span class=\"_ _27\"></span>o determine the fair value of the inventory, the Group obtained current prices<span class=\"_ _2b2\"> </span>for each of the items making up the transferred inventory<span class=\"_ _25\"></span>. <span class=\"ls1\"> </span>D. Goodwill<span class=\"_ _2b2\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Consideration transferred <span class=\"_ _236\"> </span><span class=\"wsa\">99<span class=\"_ _25\"></span>,206<span class=\"_ _2b2\"> </span></span>Interest in the identi\ufb01able net assets of non-controlling interests<span class=\"_ _29e\"> </span><span class=\"wsa\">34,<span class=\"_ _25\"></span>642<span class=\"_ _2b2\"> </span></span>Fair value of identi\ufb01able assets<span class=\"_ _29f\"> </span><span class=\"wsa\">(133,238)<span class=\"_ _2b2\"> </span></span>Goodwill<span class=\"_ _2a0\"> </span>610<span class=\"_ _2b2\"> </span>The goodwill is attributable mainly to the skills and technical talent of Oxford Biomedica Solutions\u2019 workforce. None of the goodwill<span class=\"_ _2b2\"> </span>recognised is expected to be deductible for tax purposes.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022<span class=\"_ _2b2\"> </span></span><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs8f4\">36, Non-controlling interest<span class=\"_ _2b2\"> </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8f5\">The proportion of the identi\ufb01able net assets of the Non-controlling interest in Oxfor<span class=\"_ _25\"></span>d Biomedica Solutions on acquisition was determined </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8f6\">to be \u00a334,<span class=\"_ _25\"></span>642,<span class=\"_ _25\"></span>000. Following a r<span class=\"_ _25\"></span>eview of the accounting for the acquisition of Oxford Biomedica Solutions it was identi\ufb01ed that the fair </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8f7\">value initially attributed to the non-controlling interest was not appropriate. As a r<span class=\"_ _25\"></span>esult, the group has elected to change its accounting </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8f8\">policy for the initial recognition of non-controlling interest fr<span class=\"_ _25\"></span>om fair value at date of acquisition to the holders' proportionate interest in the </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8f9\">recognised amount of the identi\ufb01able net assets of the acquiree. This valuation method better re\ufb02ects the value o<span class=\"_ _25\"></span>f the business attributable </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8fa\">to the non-controlling shareholders. This has resulted in a reduction in the initial value of non-contr<span class=\"_ _25\"></span>olling interest from \u00a348.<span class=\"_ _27\"></span>4 million to<span class=\"_ _2\"></span> </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8fb\">\u00a334.<span class=\"_ _3\"></span>6 million, a corresponding reduction of 'Goodwill' recognised on acquisition from \u00a314<span class=\"_ _25\"></span>.<span class=\"_ _3\"></span>4 million to \u00a30.<span class=\"_ _25\"></span>6 million and a reduction in the </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8fc\">'<span class=\"_ _25\"></span>Acquisition of NCI without a change in control' of \u00a311.3 million to \u00a30<span class=\"_ _25\"></span>.<span class=\"_ _3\"></span>4 million. The overall impact of this to net assets is \u00a313.8 million with </div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs8fd\">no impact to pro\ufb01t or loss recognised in the period.</div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8fe\">The following table summarises the information relating to the Group\u2019s subsidiary tha<span class=\"_ _25\"></span>t has material NCI:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8ff\">2022<span class=\"_ _2a1\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs900\">NCI percentage<span class=\"_ _2a2\"> </span><span class=\"ffa wsa\">20%<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs901\">Non current assets<span class=\"_ _2a3\"> </span><span class=\"ffa wsa\">171,419<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs902\">Current assets<span class=\"_ _26a\"> </span><span class=\"ffa wsa\">29<span class=\"_ _3\"></span>,732<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs903\">Non-current liabilities<span class=\"_ _2a4\"> </span><span class=\"ffa wsa\">(7<span class=\"_ _3\"></span>,473)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs904\">Current liabilities<span class=\"_ _2a5\"> </span><span class=\"ffa wsa\">(35,979)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs905\">Net assets\u00b9<span class=\"_ _2a6\"> </span><span class=\"ffa wsa\">157<span class=\"_ _3\"></span>,699<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs906\">Net assets attributable to NCI<span class=\"_ _2a7\"> </span><span class=\"wsa\">31,539<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h1b ff9 fs6 fc3 sc0 ls12 ws0 gs907\">\u00b9 Net assets include the impact of share based payments.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs908\">Revenue<span class=\"_ _2a8\"> </span><span class=\"ffa\">23,722<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs909\">Pro\ufb01t<span class=\"_ _2a9\"> </span><span class=\"ffa\">(30,011)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa wsa gs90a\">OCI<span class=\"_ _2aa\"> </span><span class=\"ffa\">13,756<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs90b\">T<span class=\"_ _27\"></span>otal comprehensive income<span class=\"_ _2ab\"> </span><span class=\"ffa wsa\">(16,255)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs90c\">Pro\ufb01t allocated to NCI<span class=\"_ _2ac\"> </span><span class=\"wsa\">(6,002)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs90d\">OCI allocated to NCI<span class=\"_ _2ad\"> </span><span class=\"wsa\">2,750<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs90e\">Cash \ufb02ows from operating activities<span class=\"_ _200\"> </span><span class=\"ffa wsa\">(9,732)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs90f\">Cash \ufb02ows from investment activities<span class=\"_ _1dc\"> </span><span class=\"ffa wsa\">30,867<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ff9 fs5 fc3 sc0 lsa ws0 gs910\">Cash \ufb02ow from \ufb01nancing activities (dividends to NCI: nil)<span class=\"_ _2ae\"> </span><span class=\"ffa wsa\">(2,293)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs911\">Net increase in cash and cash equivalents<span class=\"_ _2af\"> </span><span class=\"wsa\">18,842<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs912\">There was no Non-controlling interest in 2021.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h3 ffa fs1 fcb sc0 ls2 ws0 gs913\">37<span class=\"_ _3\"></span>, Acquisition of Non-controlling interest<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs914\">On 10 March 2022, the Group acquired an additional 6% interest in Oxfor<span class=\"_ _25\"></span>d Biomedica Solutions through an equity investment in Oxford </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs915\">Biomedica Solutions of \u00a338.2 million (US$50 million), increasing its ownership from 7<span class=\"_ _3\"></span>4% to 80%, leading to a dilution in the interests<span class=\"_ _2\"></span><span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs916\">of Homology Medicines from 26% to 20% . The carrying amount of Oxford Biomedica Solutions\u2019 net assets in the Group\u2019s consolidated </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs917\">\ufb01nancial statements on the date of the acquisition was \u00a3133.2 million.<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs918\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs919\">Carry amount of NCI acquired<span class=\"_ _2b0\"> </span><span class=\"wsa\">400<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs91a\">Consideration paid to NCI<span class=\"_ _1fa\"> </span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs91b\">Increase in equity attributable to owners of the Company <span class=\"_ _2ae\"> </span><span class=\"wsa\">400<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs91c\">The increase in equity attributable to owners of the Company comprised solely of an increase to retained earnings.<span class=\"_ _2b2\"> </span></div>38, Related party transactions<span class=\"_ _2b2\"> </span>Identity of related parties<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">As at 31 December 2022, the Group consisted of:<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">a parent, Oxford Biomedica plc,<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">one wholly-owned UK trading subsidiary Oxford Biomedica (UK) Limited, the principal trading company<span class=\"_ _25\"></span>,<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">one US trading subsidiary, 80% owned, Oxf<span class=\"_ _25\"></span>ord Biomedica Solutions LLC<span class=\"_ _25\"></span>,<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">one US subsidiary 100% owned, Oxford Biomedica (US) Inc,<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">one Irish wholly-owned subsidiary of the parent company<span class=\"_ _25\"></span>, Oxford Biomedica (Ireland) Ltd,<span class=\"_ _2b2\"> </span></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">one dormant subsidiary, Oxx<span class=\"_ _25\"></span>on Therapeutics Limited which was acquired and became dormant in 2007 when its assets and trade<span class=\"_ _2b2\"> </span></span>were transferred to Oxford Biomedica (UK) Limited, and<span class=\"_ _2b2\"> </span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">one additional dormant subsidiary, Invivusbio Limited, which changed its name on 18 January 2023 fr<span class=\"_ _25\"></span>om OXB Solutions Limited.<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">The registered office of the Company</span><span class=\"_ _25\"></span>, it\u2019s UK subsidiaries and Oxford Biomedica (US) Inc. is Windrush Court, T<span class=\"_ _28\"></span>ransport Way, Oxford<span class=\"_ _2b2\"> </span>OX4 6L<span class=\"_ _3\"></span>T<span class=\"_ _3\"></span><span class=\"_ _2b2\">. The registered office of Oxford Biomedica (Ireland) Ltd is Earlsfort T</span><span class=\"_ _28\"></span><span class=\"_ _2b2\">errace, Dublin 2, DO2 T380, Ireland. The registered office<span class=\"_ _2b2\"> </span></span>of OXB Solutions LL<span class=\"_ _25\"></span><span class=\"_ _2b2\">C is 1 Patriots Park, Bedford, MA 01730</span><span class=\"_ _25\"></span>, USA.<span class=\"_ _2b2\"> </span>The parent company is responsible for \ufb01nancing and setting Group strategy<span class=\"_ _25\"></span>. Oxford Biomedica (UK) Limited carries out the UK elements<span class=\"_ _2b2\"> </span>of the Group strategy<span class=\"_ _25\"></span><span class=\"_ _2b2\">, employs all the UK staff including the Executive Directors, and owns and manages all of the Group\u2019s intellectual<span class=\"_ _2b2\"> </span></span>property<span class=\"_ _25\"></span>. Oxford Biomedica Solutions carries out the US equivalent activities.<span class=\"_ _2b2\"> </span>The proceeds from the issue of shares by the parent ar<span class=\"_ _25\"></span>e passed from Oxford Biomedica plc to Oxford Biomedica (UK) Limited as a loan,<span class=\"_ _2b2\"> </span>and Oxford Biomedica (UK) Limited manages Group funds and makes payments, including the expenses of the par<span class=\"_ _25\"></span>ent company.<span class=\"_ _2b2\"> </span>Company: transactions with subsidiaries<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Purchases:<span class=\"_ _2b2\"> </span>Parent company expenses paid by subsidiary<span class=\"_ _23b\"> </span><span class=\"ffa wsa\">(10,<span class=\"_ _25\"></span>941)<span class=\"_ _6c\"> </span><span class=\"ff9\">(749)<span class=\"_ _2b2\"> </span></span></span>Cash management:<span class=\"_ _2b2\"> </span>Cash loaned by parent to subsidiary Oxford Biomedica (UK) Limited <span class=\"_ _276\"> </span><span class=\"ffa wsa\">15,780<span class=\"_ _15b\"> </span><span class=\"ff9\">12,000<span class=\"_ _2b2\"> </span></span></span>Cash loaned by parent to subsidiary Oxford Biomedica (US) Inc.<span class=\"_ _17e\"> </span><span class=\"ffa wsa\">1<span class=\"_ _25\"></span>48,764<span class=\"_ _7f\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _2b2\"> </span></span></span>The loans from Oxford Biomedica plc to Oxford Biomedica (UK) Limited and Oxfor<span class=\"_ _25\"></span>d Biomedica (US) Inc. are unsecured and interest free.<span class=\"_ _2b2\"> </span>The loans are not due, planned or expected for repayment within 12 months of the year end. The year<span class=\"_ _25\"></span>-end balance on the loans was:<span class=\"_ _2b2\"> </span>Company: year-end balance of loan<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Loan to subsidiary<span class=\"_ _2\"></span><span class=\"ls1\"> </span>Oxford Biomedica (UK) Limited<span class=\"_ _2b1\"> </span><span class=\"wsa\">278,091<span class=\"_ _de\"> </span><span class=\"ff9\">273,253<span class=\"_ _2b2\"> </span></span></span>Oxford Biomedica (US) Inc<span class=\"_ _1df\"> </span><span class=\"wsa\">148,764<span class=\"_ _9b\"> </span></span><span class=\"ff9 ls1\">\u2013<span class=\"_ _2b2\"> </span></span>The investment in the subsidiary, of which the loan f<span class=\"_ _25\"></span>orms part, has been impaired by \u00a3126.<span class=\"_ _25\"></span><span class=\"_ _2b2\">0 million (note 14) in previous years.<span class=\"_ _2b2\"> </span></span>T<span class=\"_ _27\"></span>ransactions<span class=\"_ _17b\"> </span><span class=\"ws0\">Balance Outstanding<span class=\"_ _2b2\"> </span></span>Other Related Party T<span class=\"_ _27\"></span>ransactions<span class=\"_ _2\"></span> 2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2022<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>2021<span class=\"ls1 ws0\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Sales of goods and services: Homology Medicines23,252<span class=\"_ _9b\"> </span><span class=\"ff9 ls1 ws0\">\u2013<span class=\"_ _10c\"> </span></span><span class=\"ws0\"> 4,334<span class=\"_ _7f\"> </span><span class=\"ff9 ls1\">\u2013<span class=\"_ _2b2\"> </span></span></span>Purchase of services: Homology Medicines<span class=\"_ _28d\"> </span><span class=\"ffa wsa\">4,258<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _8d\"> </span></span><span class=\"ffa wsa\">1,158<span class=\"_ _9b\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Other: Homology Medicines \u2013 rental income<span class=\"_ _170\"> </span><span class=\"ffa wsa\">1,085<span class=\"_ _7f\"> </span></span><span class=\"ls1\">\u2013<span class=\"_ _71\"> </span><span class=\"ffa ls68 ws6c\">424<span class=\"_ _9b\"> </span></span>\u2013<span class=\"_ _2b2\"> </span></span>In addition to the transactions above, options over the Company\u2019s shares have been awarded to employees of subsidiary companies.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">In accordance with IFRS 2, the Company has treated the awards as a capital contribution to the subsidiaries, resulting in a cumulative<span class=\"_ _2b2\"> </span></span>increase in the cost of investment of \u00a325,265<span class=\"_ _25\"></span>,000 (2021: \u00a318<span class=\"_ _25\"></span>,793<span class=\"_ _25\"></span>,000).<span class=\"_ _2b2\"> </span>There were no transactions (2021: none) with Oxxon Therapeutics Limited.<span class=\"_ _2b2\"> </span>Company: transactions with related parties<span class=\"_ _2b2\"> </span>There were no other outstanding balances in respect of transactions with Directors and connected persons a<span class=\"_ _25\"></span><span class=\"_ _2b2\">t 31 December 2022</span><span class=\"ls1\"> </span>(2021: none). Key person remuneration can be seen in note 5 of the \ufb01nancial statements.<span class=\"_ _2b2\"> </span>NOTES T<span class=\"_ _3\"></span>O THE CONSOLIDA<span class=\"_ _3\"></span>TED FINANCIAL ST<span class=\"_ _3\"></span>A<span class=\"_ _3\"></span><span class=\"_ _2b2\">TEMENTS (CONTINUED)<span class=\"_ _2b2\"> </span></span><span class=\"_ _2b2\">for the year ended 31 December 2022</span>",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfNotesAndOtherExplanatoryInformationExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-383": {
   "value": "Oxford Biomedica plc (Oxford Biomedica or the Company) is a public company limited by shares, incorporated and domiciled in England,  ",
   "dimensions": {
    "concept": "ifrs-full:DomicileOfEntity",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-1": {
   "value": "Oxford Biomedica plc",
   "dimensions": {
    "concept": "ifrs-full:NameOfReportingEntityOrOtherMeansOfIdentification",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-2": {
   "value": "public company limited by shares",
   "dimensions": {
    "concept": "ifrs-full:LegalFormOfEntity",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-3": {
   "value": "England",
   "dimensions": {
    "concept": "ifrs-full:CountryOfIncorporation",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-4": {
   "value": "The Group is a cell and gene therapy research, development and bioprocessing business providing services to third parties as well as  performing internal research and development for its own purposes. The Group currently has no marketed pharmaceutical products. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-387": {
   "value": "Basis of preparation The principal accounting policies adopted in the preparation of these \ufb01nancial statements are set out below. These policies have been  consistently applied to all the \ufb01nancial years presented, unless otherwise stated. The Group and parent Company \ufb01nancial statements were prepared in accordance UK-adopted international accounting standards.  As more fully explained in the Directors\u2019 Report on pages 115 to 121 and below, the going concern basis has been adopted in preparing the \ufb01nancial statements. A summary of the more important Group accounting policies is set out below. The preparation of the \ufb01nancial statements in conformity with IFRS requires the use of certain critical accounting estimates. It also requiresmanagement to exercise its judgement in the process of applying the Group\u2019s accounting policies. The areas involving a higher degree of judgement or complexity, or where assumptions and estimates are signi\ufb01cant to the \ufb01nancial statements, are disclosed in note 2. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-388": {
   "value": "<div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs32\">Measurement convention<span class=\"_ _2b2\"> </span></div><div class=\"t md h7 ff9 fs4 fc3 sc0 lse ws0 gs33\">The \ufb01nancial statements are prepared on the historical cost basis except tha<span class=\"_ _25\"></span>t the following assets and liabilities are stated at their fair value: </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs34\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Assets held at fair value through pro\ufb01t &amp; loss<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 ls1 ws0 gs35\"> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">Put option liability<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs36\">Non-current assets and disposal groups held for sale are stated at the lower o<span class=\"_ _25\"></span>f previous carrying amount and fair value less costs to sell.<span class=\"_ _2b2\"> </span></div>",
   "dimensions": {
    "concept": "ifrs-full:StatementOfIFRSCompliance",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-389": {
   "value": "Going concern The \ufb01nancial position of the Group, its cash \ufb02ows and liquidity position are described in the strategic report and notes to these \ufb01nancial  statements. The Group made a loss for the year ended 31 December 2022 of \u00a345.2 million and consumed net cash \ufb02ows from operating activities for the year of \u00a312.6 million. The Group also:  \u2014 raised \u00a377.0 million (net of \u00a33 million of share issue cost) in cash from an equity fundraise in January and March 2022;   \u2014 entered into a one year US$85 million (\u00a363 million) loan facility with Oaktree as part of the acquisition of Oxford Biomedica Solutions  in March 2022 which was then converted into a four-year term loan facility together with repayment of US$35 million of the initial  principal amount in October 2022;   \u2014 during November 2022, sold its Windrush Court facility in a sale and leaseback transaction for \u00a360 million to Kadans, whilst also  agreeing an occupational lease of the property for 15 years; and  \u2014 ended the year with cash and cash equivalents of \u00a3141.3 million.  In considering the basis of preparation of the Annual report and accounts, the Directors have prepared cash \ufb02ow forecasts for a period  of at least 12 months from the date of approval of these \ufb01nancial statements, based in the \ufb01rst instance on the Group\u2019s 2023 annual  budget and forecasts for 2024. The Directors have undertaken a rigorous assessment of this base case forecast and have also assessed  the potential impact from the principal risks and uncertainties outlined in the strategic report of the Group\u2019s Annual report and accounts,  taking into consideration the magnitude and likelihood of these risks and uncertainties occurring to prepare a downside scenario with  associated mitigated actions.  The cash \ufb02ow forecast prepared for the severe but plausible downside scenario with mitigating actions assumes the following:  \u2014 Commercial challenges leading to a substantial manufacturing and development revenue downside affecting both the LentiVector \u00ae platform and AAV businesses;  \u2014 Signi\ufb01cant decreases in forecasted existing client milestone and royalty revenues;  \u2014 The product development spin out strategy taking longer, or ultimately being unsuccessful; and  \u2014 The potential impacts of the current ongoing war in Ukraine on the Group and its clients including expected revenues from existing  clients under long term contracts. Under both the base case and mitigated downside scenario, the Group and parent company has sufficient cash resources to continue in operation for a period of at least 12 months from the date of approval of these \ufb01nancial statements. In the event of the downside scenarios crystallising, the Group would continue to meet its existing loan covenants until June 2024 without taking any mitigating actions, but the Board has mitigating actions in place that are entirely within its control that would enable the Group to reduce its spend within a reasonably short time-frame to increase its cash covenant headroom as required by the loan facility with Oaktree Capital Management. The Board has con\ufb01dence in the Group\u2019s ability to continue as a going concern for the following reasons: \u2014 The Group has cash balances of \u00a3141.3 million at the end of December 2022 and \u00a3139.1 million at the end of March 2023; \u2014 Approximately two thirds of 2023 forecasted revenues are covered by binding purchase orders which give certainty to revenues over the next 12 months; \u2014 The Group\u2019s history of being able to access capital markets including raising \u00a377 million of equity during 2022; \u2014 The Group\u2019s history of being able to obtain loan \ufb01nancing when required for purposes of both capital expenditure and operational purposes, as recently evidenced by the US$85 million one-year facility and US$50 million replacement four-year facility obtained with Oaktree; \u2014 The Group\u2019s ability to continue to be successful in winning new clients and building its brand as demonstrated by successfully entering into new and expanding existing client agreements with AstraZeneca, Juno Therapeutics (a wholly owned subsidiary of Bristol Myers Squibb Company), Homology Medicines and multiple other new partners over the last twelve months. Taking account of the matters described above, the Directors are con\ufb01dent that the Group and parent company will have sufficient funds to continue to meet their liabilities as they fall due for at least 12 months from the date of approval of the \ufb01nancial statements and therefore have prepared the \ufb01nancial statements on a going concern basis. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfGoingConcernExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-390": {
   "value": "Accounting developments The Group has adopted the following IFRSs in these \ufb01nancial statements: \u2014 Annual Improvements to IFRS Standards 2018\u20132020 \u2014 Property, Plant and Equipment: Proceed before intended use \u2013 amendments to IAS16 At the date of authorisation of these Group \ufb01nancial statements, several new, but not yet effective, Standards and amendments to existing Standards, and Interpretations have been published by the IASB. None of these Standards or amendments to existing Standards has been adopted early by the Group.The Directors anticipate that all relevant pronouncements will be adopted for the \ufb01rst period beginning on or after the effective date of the pronouncement. New Standards, amendments and Interpretations not adopted in the current year have not been disclosed as they are not expected to have a material impact on the Group \ufb01nancial statements. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-391": {
   "value": "Basis of consolidation The consolidated \ufb01nancial statements comprise the Company and its subsidiary undertakings for the year to 31 December each year. Subsidiaries are entities that are directly or indirectly controlled by the Group. Subsidiaries are consolidated from the date at which control is transferred to the Group. Control exists where the Group has the power to govern the \ufb01nancial and operating policies of the entity  so as to obtain bene\ufb01ts from its activities. The Group does not currently have any associates. All intragroup transactions and balances are eliminated on consolidation. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfBasisOfConsolidationExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-392": {
   "value": "Foreign currencies Foreign currency transactions The Group\u2019s presentational currency is sterling. Transactions in foreign currencies are translated into sterling at the rate of exchange ruling at the transaction date. Monetary assets and liabilities denominated in foreign currencies are translated into the functional currency at the exchange rate at the reporting date. Non-monetary items that are measured at fair value in a foreign currency are translated into functional currency at the exchange rate when the fair value was determined. Non-monetary items that are measured at historical cost in a foreign currency are translated at the exchange rate at the date of the transaction. Foreign currency differences are generally recognised in pro\ufb01t or loss and presented within operational costs. Foreign operations The assets and liabilities of foreign operations, including goodwill and fair value adjustments arising on acquisition, are translated into sterling at the exchanges rates at reporting date. The income and expenses of foreign operations are translated into sterling at the average exchange rate for the month based on the date of the transaction. Foreign currency differences are recognised in OCI and accumulated in the translation reserve, except to the extent that the translation difference is allocated to NCI. The assets and liabilities of foreign operations are translated to the Group\u2019s presentational currency, at foreign exchange rates in effect at the statement of \ufb01nancial position date. The revenue and expenses of foreign operations are translated at an average rate for the year where this rate approximates to the foreign exchange rates in effect at the dates of the translations. Exchange differences arising from the translation of foreign operations are reported as an item of other comprehensive income and accumulated in an exchange reserve and subsequently reclassi\ufb01ed to the Consolidated Income Statement on disposal of the net investment. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-451": {
   "value": "Foreign currency transactions The Group\u2019s presentational currency is sterling. Transactions in foreign currencies are translated into sterling at the rate of exchange ruling at the transaction date. Monetary assets and liabilities denominated in foreign currencies are translated into the functional currency at the exchange rate at the reporting date. Non-monetary items that are measured at fair value in a foreign currency are translated into functional currency at the exchange rate when the fair value was determined. Non-monetary items that are measured at historical cost in a foreign currency are translated at the exchange rate at the date of the transaction. Foreign currency differences are generally recognised in pro\ufb01t or loss and presented within operational costs. Foreign operations The assets and liabilities of foreign operations, including goodwill and fair value adjustments arising on acquisition, are translated into sterling at the exchanges rates at reporting date. The income and expenses of foreign operations are translated into sterling at the average exchange rate for the month based on the date of the transaction. Foreign currency differences are recognised in OCI and accumulated in the translation reserve, except to the extent that the translation difference is allocated to NCI. The assets and liabilities of foreign operations are translated to the Group\u2019s presentational currency, at foreign exchange rates in effect at the statement of \ufb01nancial position date. The revenue and expenses of foreign operations are translated at an average rate for the year where this rate approximates to the foreign exchange rates in effect at the dates of the translations. Exchange differences arising from the translation of foreign operations are reported as an item of other comprehensive income and accumulated in an exchange reserve and subsequently reclassi\ufb01ed to the Consolidated Income Statement on disposal of the net investment. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-393": {
   "value": "Revenue Revenue comprises income derived from bioprocessing of clinical product for clients, fees charged for providing development services to clients, product and technology licence transactions, royalties, options, and funded research and development programmes. Platform The Group bioprocesses batches on behalf of clients who use this manufactured clinical product for clinical and commercial purposes. The bioprocessing of a batch creates an asset with no alternative use and the Group has an enforceable right to payment for performance completed to date, thereby meeting IFRS 15.35. Bioprocessing of clinical/commercial product for clients is therefore recognised on a percentage of completion basis over time as the processes are carried out using the Input Method under IFRS. Progress is determined based on the achievement of veri\ufb01able stages of the process with incremental adjustments made based on the percentage of completion of the next unachieved veri\ufb01able stage. The gross amount due from clients, on all partnerships with regards to bioprocessing batches in progress for which costs incurred plus recognised pro\ufb01ts exceed progress billings, is presented separately as a contract asset within the note to Trade and Other receivables as presented in the statement of \ufb01nancial position. Consideration received in excess of the stage of completion will be deferred until such time as it is appropriate to recognise the revenue. The Group has determined that its contracts with clients do not contain a signi\ufb01cant \ufb01nancing component. Revenues for providing process development activities to clients are recognised during the period in which the service is rendered on a percentage of completion basis over time as the processes are carried out. The process development activities are recognized over time as the activities create an asset that has no alternative use to the Group and the Group has an enforceable right to payment for the work packages within the process development activity completed to date. \u2014 Oxford Biomedica (UK) Ltd makes use of the output method under IFRS with revenue being recognised based on the achievement of veri\ufb01able stages of the process.  \u2014 Oxford Biomedica Solutions makes use of the input method under IFRS with revenue being recognised based on the labour and other resources expended to provide the services as a percentage of the total expected effort to complete the services. Technology licences that have been established by the Group have all been determined as \u201cright to use\u201d licences, rather than \u201cright to access\u201d licences. As such, the revenue from these licences is recognised at the point in time at which the licence transfers to the client. The granting of the technology licences to the Group\u2019s background intellectual property and know-how constitutes a \u201cright to use\u201d licence as the Group\u2019s clients are able to conduct development work on the licence independent of the Group. The Group is incentivised separately for its performance obligations in relation to development work and milestone payments. The criteria for recognising these technology licences as \u201cright to access\u201d licences has therefore not been met. Milestones relating to bioprocessing or process development activities have been identi\ufb01ed as separate performance obligations as they involve the transfer of a distinct good or service, determined with reference to conditions stipulated in the relevant agreements or contracts. Each milestone is determined as either binary or non-binary. Milestones that are considered to be binary relate to the achievement of speci\ufb01c events rather than the provision of, for example, support. Milestones related to the achievement of speci\ufb01c deliverables are considered to be binary milestones and will be recognised in full once it is deemed highly probable that the obligation will be met. Milestones related to the provision of support services are considered to be non-binary Milestones and are recognised on a percentage of completion basis, but taking into account the likelihood of achievement of the deliverable. Amounts receivable on delivery of a milestone performance obligation represents variable consideration and have been allocated to the relevant performance obligation. Options to technology licences are considered to form part of the technology licence performance obligation and as such are recognised when the client exercises the option to obtain that licence. Options to technology licences are not considered to be material rights.Product Product licences that have been established by the Group have all been determined as \u201cright to use\u201d licences, rather than \u201cright to access\u201d licences. As such, the revenue from these licences is recognised at the point in time at which the licence transfers to the client. The granting of the product licences to the Group\u2019s background intellectual property and know-how constitutes a \u201cright to use\u201d licence as the Group\u2019s clients are able to conduct development work on the licence independent of the Group. The Group is incentivised separately for its performance obligations in relation to development work and milestone payments. The criteria for recognising these technology licences as \u201cright to access\u201d licences has therefore not been met. Amounts receivable in respect of milestone payments are considered to be separate performance obligations which are binary and will be recognised in full once it is deemed highly probable that the speci\ufb01c performance obligations stipulated in the licence agreement have been met. Payments linked to \u201csuccess\u201d such as regulatory \ufb01ling or approval, or achievement of speci\ufb01ed sales volumes, are recognised in full when the relevant event has occurred. Non-binary milestones are recognised on a percentage of completion basis in the period in which related costs are incurred, or over the estimated period to completion of the relevant phase of development or associated clinical trials. Amounts receivable on delivery of a milestone performance obligation represents variable consideration and have been allocated to the relevant performance obligation. Royalty revenue is recognised as the underlying commercial sales of the underlying manufactured product occur to third parties of our contracted clients. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForRecognitionOfRevenue",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-394": {
   "value": "Cost of sales Cost of sales comprises the cost of bioprocessing clinical product for clients, the cost of client development project activities, and royalties arising on clients\u2019 licences. The cost of client development project activities includes the labour costs, overheads and other directly attributable material and third party costs. Costs are recognised as incurred. The cost of bioprocessing clinical product for clients includes the raw materials, labour costs, overheads and other directly attributable third party costs. Costs are recognised as incurred. The Group\u2019s products and technologies include technology elements that are licensed from third parties. Royalties arising from such clients\u2019 licences are treated as cost of sales. Where royalties due have not been paid they are included in accruals. Where revenue is spread over a number of accounting periods, the royalty attributable to the deferred revenue is included in prepayments. ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DescriptionOfAccountingPolicyForCostOfSales",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-395": {
   "value": "Research, development and bioprocessing Research, development and bioprocessing expenditure is charged to the statement of comprehensive income in the period in which it is incurred. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-396": {
   "value": "Employee bene\ufb01t costs Employee bene\ufb01t costs, notably holiday pay and contributions to the Group\u2019s de\ufb01ned contribution pension plan, are charged to the statement of comprehensive income on an accruals basis. The assets of the pension scheme are held separately from those of the Group in independently administered funds. The Group does not offer any other post-retirement bene\ufb01ts. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-397": {
   "value": "Share based payments The Group\u2019s employee share option schemes, long term incentive plans, a Sharesave scheme and deferred bonus plans allow Group employees to acquire shares of the Company subject to certain criteria. The fair value of options granted is recognised as an expense of employment in the statement of comprehensive income with a corresponding increase in equity. The fair value is measured at the date of grant and spread over the period during which the employees become unconditionally entitled to the options where the options are not nil cost options. Nil cost options are valued at the market price on the date of grant of the options. The fair value of options granted under the share option schemes and share save scheme is measured using the Black-Scholes model. The fair value of options granted under the LTIP schemes, which includes market condition performance criteria, is measured using a Monte Carlo model taking into account the performance conditions under which the options were granted. The fair value of options granted under the deferred bonus plan is based on the market value of the underlying shares at the date of grant of these options. At each \ufb01nancial year end, the Group revises its estimate of the number of options that are expected to become exercisable based on forfeiture such that at the end of the vesting period the cumulative charge re\ufb02ects the actual options that have vested, with no charge for those options which were forfeit prior to vesting. When share options are exercised the proceeds received are credited to equity. Options over the Company\u2019s shares have been awarded to employees of Oxford Biomedica (UK) Ltd. In accordance with IFRS 2 \u2019Share- based Payments\u2019, the expense in respect of these awards is recognised in the subsidiaries\u2019 \ufb01nancial statements. In accordance with IFRS 2 the Company has treated the awards as a capital contribution to the subsidiaries, resulting in an increase in the cost of investment and a corresponding credit to reserves. Employee Bene\ufb01t Trust The Oxford Biomedica Employee Bene\ufb01t Trust (EBT) has been set up to hold market-purchased shares to settle the 2013 Deferred Bonus Share Awards made to Executive Directors and employees. Within the Company \ufb01nancial statements, the investment in the Oxford Biomedica Employee Trust forms part of the Investments and loans in subsidiary, taking the form of a loan to subsidiaries. The EBT is consolidated within the Group \ufb01nancial statements. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-398": {
   "value": "Leases<span class=\"_ _2b2\"> </span>As a lessee<span class=\"_ _2b2\"> </span>At commencement or on modi\ufb01cation of a contract that contains a lease component, the Group allocates the consideration in the contract to each lease component on the basis of its relative stand-alone prices. However<span class=\"_ _3\"></span>, for the leases of property, the Group has elected not to separate non-lease components, and to account for the lease and non-lease components as a single lease component.<span class=\"_ _2b2\"> </span>The Group recognises a right-of-use asset and a lease liability at the lease commencement date. The right-of-use asset is initially measured at cost, which comprises the initial amount of the lease liability adjusted for any lease payments made at or before the commencement date, plus any initial direct costs incurred, and an estimate of costs to dismantle and remove the underlying asset, <span class=\"ls1\"> </span>or to restore the underlying asset or site on which it is located, less any lease incentives received.<span class=\"_ _2b2\"> </span>The right-of-use asset is subsequently depreciated using the straight-line method, from the commencement date to the end of the lease term, unless the lease transfers ownership of the underlying asset to the Group by the end of the lease term, or the cost of the right-of-<span class=\"_ _2b2\"> </span>use asset re\ufb02ects that the Group will exercise a pur<span class=\"_ _25\"></span>chase option. In that case, the right-of-use asset will be depreciated over the useful life of the underlying asset, which is determined on the same basis as those of property and equipment. In addition, the right-of-use asset is periodically reduced by impairment losses, if any<span class=\"_ _25\"></span>, and adjusted for certain re-measurements of the lease liability<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>The lease liability is initially measured at the present value of the lease payments that are not paid a<span class=\"_ _25\"></span>t the commencement date, discounted<span class=\"_ _2b2\"> </span> using the interest rate implicit in the lease or<span class=\"_ _25\"></span>, if that rate cannot be readily determined, the Group\u2019s incr<span class=\"_ _25\"></span>emental borrowing rate. Generally<span class=\"_ _25\"></span>,<span class=\"_ _2b2\"> </span> the Group uses its incremental borrowing rate as the discount rate.<span class=\"_ _2b2\"> </span>The Group determines its incremental borrowing rate by obtaining relevant inter<span class=\"_ _25\"></span>est rates from external \ufb01nancing sources and makes<span class=\"_ _2b2\"> </span> certain adjustments to re\ufb02ect the terms of the lease and the type of the asset leased.<span class=\"_ _2b2\"> </span>Lease payments included in the measurement of the lease liability comprise \ufb01xed payments.<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">The lease liability is measured at amortised cost using the effective interest method. It is re-measur</span><span class=\"_ _25\"></span>ed if:<span class=\"_ _2b2\"> </span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">there is a change in the Group\u2019s estimate of the amount expected to be payable under a residual futur<span class=\"_ _25\"></span>e lease payments;<span class=\"_ _2b2\"> </span></span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">the Group changes its assessment of whether it will exercise a purchase, extension or termina<span class=\"_ _25\"></span>tion options; or<span class=\"_ _2b2\"> </span></span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">there is a revised in-substance \ufb01xed lease payment.<span class=\"_ _2b2\"> </span></span>If a lease liability is re-measured, a corresponding adjustment is made to the carrying amount of the right-of-use asset, or is r<span class=\"_ _25\"></span>ecorded in<span class=\"_ _2b2\"> </span> the Pro\ufb01t or Loss if the carrying amount of the right-of-use asset has been reduced to zer<span class=\"_ _25\"></span>o.<span class=\"_ _2b2\"> </span>The Group presents right-of-use assets in \u2019property<span class=\"_ _25\"></span>, plant and equipment\u2019 and lease liabilities as a category on the face of the Statement<span class=\"_ _2b2\"> </span> of Financial Position.<span class=\"_ _2b2\"> </span>Short term or low-value leases<span class=\"_ _2b2\"> </span>The Group has elected not to recognise right-of-use assets and lease liabilities of short term and low-value leases. The Group r<span class=\"_ _25\"></span>ecognises<span class=\"_ _2b2\"> </span> lease payments associated with these leases as an expense on a straight-line basis over the lease term.<span class=\"_ _2b2\"> </span>Sales &amp; Leaseback<span class=\"_ _2b2\"> </span>A sale and leaseback is where the Group sells an asset and immediately reacquires the use o<span class=\"_ _25\"></span>f the asset by entering into a lease with the<span class=\"_ _2b2\"> </span> buyer<span class=\"_ _25\"></span>.<span class=\"_ _2b2\"> </span>For sale and operating leasebacks, generally the assets are sold at fair value, and accordingly the pro\ufb01ts and loss fr<span class=\"_ _25\"></span>om the sale are recognised immediately in the Statement of Pro\ufb01t and loss. The fair value is determined by obtaining a valua<span class=\"_ _25\"></span>tion from an independent property valuation \ufb01rm.A sale occurs when control of the underlying asset passes to the buyer<span class=\"_ _25\"></span>. A lease liability is recognised, the associated property<span class=\"_ _3\"></span>, plant<span class=\"_ _2\"></span> and equipment asset is derecognised, and a right of use asset is recognised at the proportion of the carrying value r<span class=\"_ _25\"></span>elating to the right<span class=\"_ _2b2\"> </span> retained. Any gain or loss arising relates to the rights transferred to the buyer<span class=\"_ _3\"></span>.<span class=\"_ _2b2\"> </span>",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForLeasesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-399": {
   "value": "Grants Income from government and other grants is recognised over the period necessary to match them with the related costs which they  are intended to compensate. Grant income is included as other operating income within the statement of comprehensive income, and  the related costs are included within research, development and bioprocessing costs, and administrative expenses. Where grant income  received exceeds grant income recognised, it is included within deferred income on the Statement of \ufb01nancial position, whereas grant  income recognised exceeds grant income received, it is included within accrued income on the Statement of \ufb01nancial position. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForGovernmentGrants",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-452": {
   "value": "Finance income and costs Finance income and costs comprise interest income and interest payable during the year, calculated using the effective interest rate  method. It also includes the revaluation of external loans denominated in a foreign currency. Financing expenses include interest payable and \ufb01nance charges on lease liabilities recognised in pro\ufb01t or loss using the effective interest  method and unwinding of the discount on provisions. Interest income and interest payable is recognised in pro\ufb01t or loss as it accrues, using the effective interest method. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForFinanceCostsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-400": {
   "value": "Finance income and costs Finance income and costs comprise interest income and interest payable during the year, calculated using the effective interest rate  method. It also includes the revaluation of external loans denominated in a foreign currency. Financing expenses include interest payable and \ufb01nance charges on lease liabilities recognised in pro\ufb01t or loss using the effective interest  method and unwinding of the discount on provisions. Interest income and interest payable is recognised in pro\ufb01t or loss as it accrues, using the effective interest method. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-401": {
   "value": "Taxation In 2022 and before, the Group was entitled to claim tax credits in the United Kingdom for certain research and development expenditure.  The Group receives a Research and Development Expenditure Credit (\u2019RDEC\u2019) which is accounted for as a reduction in research and  development costs in the statement of comprehensive income, and within trade and other receivables in the Statement of \ufb01nancial  position. The credit is paid in arrears once tax returns have been \ufb01led and agreed. Current tax, including UK corporation tax and foreign tax, is provided at amounts expected to be paid (or recovered) using the tax rates  and laws that have been enacted, or substantially enacted, by the Statement of \ufb01nancial position date. Deferred tax is calculated in respect of all temporary differences identi\ufb01ed at the Statement of \ufb01nancial position date except for: the  initial recognition of goodwill; the initial recognition of assets or liabilities that affect neither accounting nor taxable pro\ufb01t other than in  a business combination, and differences relating to investments in subsidiaries to the extent that they will probably not reverse in the  foreseeable future. Temporary differences are differences between the carrying amount of the Group\u2019s assets and liabilities and their tax base. Deferred tax  liabilities may be offset against deferred tax assets within the same taxable entity or qualifying local tax group. Any remaining deferred  tax asset is recognised only when, on the basis of all available evidence, it can be regarded as probable that there will be suitable taxable  pro\ufb01ts within the same jurisdiction in the foreseeable future against which the deductible temporary difference can be utilised.  Deferred tax is measured at the average tax rates that are expected to apply in the periods in which the asset is realised or liability settled, based on tax rates and laws that have been enacted or substantially enacted by the Statement of \ufb01nancial position date. Measurement of deferred tax liabilities and assets re\ufb02ects the tax consequence expected to fall from the manner in which the asset or liability is recovered or settled. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForIncomeTaxExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-453": {
   "value": "Deferred tax is calculated in respect of all temporary differences identi\ufb01ed at the Statement of \ufb01nancial position date except for: the  initial recognition of goodwill; the initial recognition of assets or liabilities that affect neither accounting nor taxable pro\ufb01t other than in  a business combination, and differences relating to investments in subsidiaries to the extent that they will probably not reverse in the  foreseeable future. Temporary differences are differences between the carrying amount of the Group\u2019s assets and liabilities and their tax base. Deferred tax  liabilities may be offset against deferred tax assets within the same taxable entity or qualifying local tax group. Any remaining deferred  tax asset is recognised only when, on the basis of all available evidence, it can be regarded as probable that there will be suitable taxable  pro\ufb01ts within the same jurisdiction in the foreseeable future against which the deductible temporary difference can be utilised.  Deferred tax is measured at the average tax rates that are expected to apply in the periods in which the asset is realised or liability settled, based on tax rates and laws that have been enacted or substantially enacted by the Statement of \ufb01nancial position date. Measurement of deferred tax liabilities and assets re\ufb02ects the tax consequence expected to fall from the manner in which the asset or liability is recovered or settled. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForDeferredIncomeTaxExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-402": {
   "value": "Property, plant and equipment Property, plant and equipment are carried at cost, together with any incidental expenses of acquisition, less depreciation. Cost includes the original purchase price of the asset and any costs attributable to bringing the asset to its working condition for its intended use. Depreciation is calculated to write off the cost of property, plant and equipment less their estimated residual values on a straight-line basis over the expected useful economic lives of the assets concerned. Depreciation of an asset begins when it is available for use. The principal annual rates used for this purpose are: Freehold property 10% Leasehold improvements 10% (over the remaining lease term if shorter) Office equipment and computers 20\u201333% Bioprocessing and laboratory equipment 20% The assets\u2019 residual values and useful lives are reviewed annually. Residual values are set at zero and will be reassessed should the asset\u2019s selling price exceed its net book value. The bioprocessing plants are reviewed annually for impairment triggers and, where necessary, a full impairment review is performed. Assets under construction are capitalised throughout the course of the construction period with depreciation starting once the asset is available for use. Assets capitalised under a category of \ufb01xed assets may be transferred to another category within \ufb01xed assets if, upon review, it is identi\ufb01ed that the asset is more appropriately identi\ufb01able with that other category of \ufb01xed asset. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-478": {
   "value": "Intangible assets &amp; Goodwill<span class=\"_ _2b2\"> </span>Recognition and measurement<span class=\"_ _2b2\"> </span>Goodwill<span class=\"_ _2b2\"> </span>Goodwill arising on the acquisition of subsidiaries is measured at cost less accumulated impairment losses.<span class=\"_ _2b2\"> </span>Developed technology<span class=\"_ _2b2\"> </span>Developed technology acquired by the Group (see note 11) has a \ufb01nite useful life. It is measured at cost less accumulated amortisation and any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Patents<span class=\"_ _2b2\"> </span>Patents have \ufb01nite useful lives and are measured at cost less accumulated amortisation and <span class=\"ls1\"> </span>any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Subsequent expenditure<span class=\"_ _2b2\"> </span>Subsequent expenditure is capitalised only when it increases the future economic bene\ufb01ts embodied in the speci\ufb01c asset to which it relates. All other expenditure, including expenditure on internally generated goodwill and brands, is r<span class=\"_ _25\"></span>ecognised in pro\ufb01t or loss as incurred.<span class=\"_ _2b2\"> </span>Cash generating unit (CGU)<span class=\"_ _2b2\"> </span>A cash generating unit is the smallest group of assets that independently generates cash \ufb02ow and whose cash \ufb02ow is largely independent of the cash \ufb02ows generated by other assets.<span class=\"_ _2b2\"> </span>Amortisation<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Amortisation is calculated to write off the cost of intangible assets less their estimated residual values using the straight-line method over </span>their estimated useful lives, and is generally recognised in pro\ufb01t or loss. Goodwill is not amortised. The estimated useful lives for current and comparative periods are as follows:  <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">patents: 3\u201320 years</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">developed technology: 15 years<span class=\"_ _2b2\"> </span></span>Amortisation methods, useful lives and residual values are reviewed at each r<span class=\"_ _25\"></span>eporting date and adjusted if appropriate.<span class=\"_ _2b2\"> </span>Impairment<span class=\"_ _2b2\"> </span>The carrying value of non-\ufb01nancial assets is reviewed annually for impairment, or earlier if an indication of impairment occurs, and  <span class=\"_ _32\"></span>provision made where appropriate. Charges or cr<span class=\"_ _25\"></span>edits for impairment are passed through the statement of comprehensive income.<span class=\"_ _2b2\"> </span>For the purposes of assessing impairments, assets are grouped at the lowest levels for which there ar<span class=\"_ _25\"></span>e separately identi\ufb01able cash \ufb02ows or<span class=\"_ _2b2\"> </span> cash-generating units. Impairment losses are recognised for the amount by which each asset\u2019s carrying amount exceeds its r<span class=\"_ _25\"></span>ecoverable<span class=\"_ _2b2\"> </span> amount. The recoverable amount is the higher of an asset\u2019s fair value less costs to sell, and value in use. V<span class=\"_ _25\"></span>alue in use is calculated using<span class=\"_ _2b2\"> </span> estimated discounted future cash \ufb02ows. The key assumptions used in calculating the discounted future cash \ufb02ows ar<span class=\"_ _25\"></span>e management<span class=\"_ _2b2\"> </span> estimates, based where possible on available market informa<span class=\"_ _25\"></span>tion and information for similar products.<span class=\"_ _2b2\"> </span>Impairment and amortisation charges are included within research, development and biopr<span class=\"_ _25\"></span>ocessing costs in the statement of<span class=\"_ _2b2\"> </span> comprehensive income.<span class=\"_ _2b2\"> </span>Intellectual property rights comprise third party patent rights or rights to market commercial pr<span class=\"_ _25\"></span>oducts for key therapeutic indications that<span class=\"_ _2b2\"> </span> have been purchased by the Group.<span class=\"_ _2b2\"> </span>",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForGoodwillExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-454": {
   "value": "Intangible assets &amp; Goodwill<span class=\"_ _2b2\"> </span>Recognition and measurement<span class=\"_ _2b2\"> </span>Goodwill<span class=\"_ _2b2\"> </span>Goodwill arising on the acquisition of subsidiaries is measured at cost less accumulated impairment losses.<span class=\"_ _2b2\"> </span>Developed technology<span class=\"_ _2b2\"> </span>Developed technology acquired by the Group (see note 11) has a \ufb01nite useful life. It is measured at cost less accumulated amortisation and any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Patents<span class=\"_ _2b2\"> </span>Patents have \ufb01nite useful lives and are measured at cost less accumulated amortisation and <span class=\"ls1\"> </span>any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Subsequent expenditure<span class=\"_ _2b2\"> </span>Subsequent expenditure is capitalised only when it increases the future economic bene\ufb01ts embodied in the speci\ufb01c asset to which it relates. All other expenditure, including expenditure on internally generated goodwill and brands, is r<span class=\"_ _25\"></span>ecognised in pro\ufb01t or loss as incurred.<span class=\"_ _2b2\"> </span>Cash generating unit (CGU)<span class=\"_ _2b2\"> </span>A cash generating unit is the smallest group of assets that independently generates cash \ufb02ow and whose cash \ufb02ow is largely independent of the cash \ufb02ows generated by other assets.<span class=\"_ _2b2\"> </span>Amortisation<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Amortisation is calculated to write off the cost of intangible assets less their estimated residual values using the straight-line method over </span>their estimated useful lives, and is generally recognised in pro\ufb01t or loss. Goodwill is not amortised. The estimated useful lives for current and comparative periods are as follows:  <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">patents: 3\u201320 years</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">developed technology: 15 years<span class=\"_ _2b2\"> </span></span>Amortisation methods, useful lives and residual values are reviewed at each r<span class=\"_ _25\"></span>eporting date and adjusted if appropriate.<span class=\"_ _2b2\"> </span>Impairment<span class=\"_ _2b2\"> </span>The carrying value of non-\ufb01nancial assets is reviewed annually for impairment, or earlier if an indication of impairment occurs, and  <span class=\"_ _32\"></span>provision made where appropriate. Charges or cr<span class=\"_ _25\"></span>edits for impairment are passed through the statement of comprehensive income.<span class=\"_ _2b2\"> </span>For the purposes of assessing impairments, assets are grouped at the lowest levels for which there ar<span class=\"_ _25\"></span>e separately identi\ufb01able cash \ufb02ows or<span class=\"_ _2b2\"> </span> cash-generating units. Impairment losses are recognised for the amount by which each asset\u2019s carrying amount exceeds its r<span class=\"_ _25\"></span>ecoverable<span class=\"_ _2b2\"> </span> amount. The recoverable amount is the higher of an asset\u2019s fair value less costs to sell, and value in use. V<span class=\"_ _25\"></span>alue in use is calculated using<span class=\"_ _2b2\"> </span> estimated discounted future cash \ufb02ows. The key assumptions used in calculating the discounted future cash \ufb02ows ar<span class=\"_ _25\"></span>e management<span class=\"_ _2b2\"> </span> estimates, based where possible on available market informa<span class=\"_ _25\"></span>tion and information for similar products.<span class=\"_ _2b2\"> </span>Impairment and amortisation charges are included within research, development and biopr<span class=\"_ _25\"></span>ocessing costs in the statement of<span class=\"_ _2b2\"> </span> comprehensive income.<span class=\"_ _2b2\"> </span>Intellectual property rights comprise third party patent rights or rights to market commercial pr<span class=\"_ _25\"></span>oducts for key therapeutic indications that<span class=\"_ _2b2\"> </span> have been purchased by the Group.<span class=\"_ _2b2\"> </span>",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-403": {
   "value": "Intangible assets &amp; Goodwill<span class=\"_ _2b2\"> </span>Recognition and measurement<span class=\"_ _2b2\"> </span>Goodwill<span class=\"_ _2b2\"> </span>Goodwill arising on the acquisition of subsidiaries is measured at cost less accumulated impairment losses.<span class=\"_ _2b2\"> </span>Developed technology<span class=\"_ _2b2\"> </span>Developed technology acquired by the Group (see note 11) has a \ufb01nite useful life. It is measured at cost less accumulated amortisation and any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Patents<span class=\"_ _2b2\"> </span>Patents have \ufb01nite useful lives and are measured at cost less accumulated amortisation and <span class=\"ls1\"> </span>any accumulated impairment losses.<span class=\"_ _2b2\"> </span>Subsequent expenditure<span class=\"_ _2b2\"> </span>Subsequent expenditure is capitalised only when it increases the future economic bene\ufb01ts embodied in the speci\ufb01c asset to which it relates. All other expenditure, including expenditure on internally generated goodwill and brands, is r<span class=\"_ _25\"></span>ecognised in pro\ufb01t or loss as incurred.<span class=\"_ _2b2\"> </span>Cash generating unit (CGU)<span class=\"_ _2b2\"> </span>A cash generating unit is the smallest group of assets that independently generates cash \ufb02ow and whose cash \ufb02ow is largely independent of the cash \ufb02ows generated by other assets.<span class=\"_ _2b2\"> </span>Amortisation<span class=\"_ _2b2\"> </span><span class=\"_ _2b2\">Amortisation is calculated to write off the cost of intangible assets less their estimated residual values using the straight-line method over </span>their estimated useful lives, and is generally recognised in pro\ufb01t or loss. Goodwill is not amortised. The estimated useful lives for current and comparative periods are as follows:  <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">patents: 3\u201320 years</span> <span class=\"_ _30\"></span>\u2014<span class=\"_ _31\"> </span><span class=\"lse\">developed technology: 15 years<span class=\"_ _2b2\"> </span></span>Amortisation methods, useful lives and residual values are reviewed at each r<span class=\"_ _25\"></span>eporting date and adjusted if appropriate.<span class=\"_ _2b2\"> </span>Impairment<span class=\"_ _2b2\"> </span>The carrying value of non-\ufb01nancial assets is reviewed annually for impairment, or earlier if an indication of impairment occurs, and  <span class=\"_ _32\"></span>provision made where appropriate. Charges or cr<span class=\"_ _25\"></span>edits for impairment are passed through the statement of comprehensive income.<span class=\"_ _2b2\"> </span>For the purposes of assessing impairments, assets are grouped at the lowest levels for which there ar<span class=\"_ _25\"></span>e separately identi\ufb01able cash \ufb02ows or<span class=\"_ _2b2\"> </span> cash-generating units. Impairment losses are recognised for the amount by which each asset\u2019s carrying amount exceeds its r<span class=\"_ _25\"></span>ecoverable<span class=\"_ _2b2\"> </span> amount. The recoverable amount is the higher of an asset\u2019s fair value less costs to sell, and value in use. V<span class=\"_ _25\"></span>alue in use is calculated using<span class=\"_ _2b2\"> </span> estimated discounted future cash \ufb02ows. The key assumptions used in calculating the discounted future cash \ufb02ows ar<span class=\"_ _25\"></span>e management<span class=\"_ _2b2\"> </span> estimates, based where possible on available market informa<span class=\"_ _25\"></span>tion and information for similar products.<span class=\"_ _2b2\"> </span>Impairment and amortisation charges are included within research, development and biopr<span class=\"_ _25\"></span>ocessing costs in the statement of<span class=\"_ _2b2\"> </span> comprehensive income.<span class=\"_ _2b2\"> </span>Intellectual property rights comprise third party patent rights or rights to market commercial pr<span class=\"_ _25\"></span>oducts for key therapeutic indications that<span class=\"_ _2b2\"> </span> have been purchased by the Group.<span class=\"_ _2b2\"> </span>",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForIntangibleAssetsAndGoodwillExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-404": {
   "value": "Investments in subsidiaries Investments are carried at cost less any provision made for impairment. Options over the Company\u2019s shares have been awarded to  employees of subsidiary companies. In accordance with IFRS2, the Company treats the value of these awards as a capital contribution to the subsidiaries, resulting in an increase in the cost of investment. Investments in subsidiary undertakings, including shares and loans, are carried at cost less any impairment provision. Such investments are  subject to review, and any impairment is charged to the statement of comprehensive income. At each year end the Directors review the carrying value of the Company\u2019s investment in subsidiaries. Where there is a material and  sustained shortfall in the market capitalisation, or a signi\ufb01cant and sustained change in the business resulting in a decrease in market  capitalisation, the Directors consider this to be a trigger of an impairment review as set out in IAS 36, and the carrying value of the  Company\u2019s investments in subsidiaries is adjusted. The Directors consider that reference to the market capitalisation of the Group is an appropriate external measure of the value of the Company\u2019s subsidiaries for this purpose. At year end the Directors will assess the requirement to write back a portion or all of any impairment previously recognised on its  investment in subsidiaries. Factors which will be taken into account with regard to this decision will be the Groups track record of  improved \ufb01nancial results across the last three to four years, as well as the expectation of future impairments being required after a write  back was accounted for. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForSubsidiariesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-405": {
   "value": "Financial assets Assets at fair value through pro\ufb01t and loss The gain or loss on Assets at fair value through pro\ufb01t and loss is recognised in the statement of comprehensive income. Investments Other investments held by the Group are classi\ufb01ed as at fair value through pro\ufb01t and loss. Bank deposits Bank deposits with original maturities between three months and twelve months are included in current assets and are valued at amortised cost. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForFinancialAssetsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-406": {
   "value": "Financial instruments Classi\ufb01cation On initial recognition, a \ufb01nancial asset is classi\ufb01ed as measured at: amortised cost; FVOCI \u2013 debt investment; FVOCI \u2013 equity investment;  or FVTPL. Financial assets are not reclassi\ufb01ed subsequent to their initial recognition unless the Company changes its business model for  managing \ufb01nancial assets in which case all affected \ufb01nancial assets are reclassi\ufb01ed on the \ufb01rst day of the \ufb01rst reporting period following  the change in the business model. A \ufb01nancial asset is measured at amortised cost if it meets both of the following conditions and is not designated as at FVTPL:  \u2014 it is held within a business model whose objective is to hold assets to collect contractual cash \ufb02ows; and  \u2014 its contractual terms give rise on speci\ufb01ed dates to cash \ufb02ows that are solely payments of principal and interest on the principal  amount outstanding. A debt investment is measured at FVOCI if it meets both of the following conditions and is not designated as at FVTPL:  \u2014 it is held within a business model whose objective is achieved by both collecting contractual cash \ufb02ows and selling \ufb01nancial assets;  and  \u2014 its contractual terms give rise on speci\ufb01ed dates to cash \ufb02ows that are solely payments of principal, and interest on the principal  amount outstanding. On initial recognition of an equity investment that is not held for trading, the Company may irrevocably elect to present subsequent  changes in the investment\u2019s fair value in OCI. This election is made on an investment-by-investment basis. All \ufb01nancial assets not classi\ufb01ed as measured at amortised cost or FVOCI as described above, are measured at FVTPL. This includes  all derivative \ufb01nancial assets. On initial recognition, the Group may irrevocably designate a \ufb01nancial asset that otherwise meets the  requirements to be measured at amortised cost or at FVOCI, as at FVTPL if doing so eliminates, or signi\ufb01cantly reduces an accounting  mismatch that would otherwise arise. Derecognition Financial assets The Group derecognises a \ufb01nancial asset when: \u2014 the contractual rights to the cash \ufb02ows from the \ufb01nancial asset expire; or \u2014 it transfers the rights to receive the contractual cash \ufb02ows in a transaction in which either; or \u2014 substantially all of the risks and rewards of ownership of the \ufb01nancial asset are transferred; or \u2014 the Group neither transfers nor retains substantially all of the risks and rewards of ownership, and it does not retain control of the \ufb01nancial asset. Financial liabilities The Group derecognises a \ufb01nancial liability when its contractual obligations are discharged or cancelled, or expire. The Group also derecognises a \ufb01nancial liability when its terms are modi\ufb01ed and the cash \ufb02ows of the modi\ufb01ed liability are substantially different, in which case a new \ufb01nancial liability based on the modi\ufb01ed terms is recognised at fair value. On derecognition of a \ufb01nancial liability, the difference between the carrying amount extinguished and the consideration paid (including any non-cash assets transferred or liabilities assumed), is recognised in pro\ufb01t or loss. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-455": {
   "value": "Derecognition Financial assets The Group derecognises a \ufb01nancial asset when: \u2014 the contractual rights to the cash \ufb02ows from the \ufb01nancial asset expire; or \u2014 it transfers the rights to receive the contractual cash \ufb02ows in a transaction in which either; or \u2014 substantially all of the risks and rewards of ownership of the \ufb01nancial asset are transferred; or \u2014 the Group neither transfers nor retains substantially all of the risks and rewards of ownership, and it does not retain control of the \ufb01nancial asset. Financial liabilities The Group derecognises a \ufb01nancial liability when its contractual obligations are discharged or cancelled, or expire. The Group also derecognises a \ufb01nancial liability when its terms are modi\ufb01ed and the cash \ufb02ows of the modi\ufb01ed liability are substantially different, in which case a new \ufb01nancial liability based on the modi\ufb01ed terms is recognised at fair value. On derecognition of a \ufb01nancial liability, the difference between the carrying amount extinguished and the consideration paid (including any non-cash assets transferred or liabilities assumed), is recognised in pro\ufb01t or loss. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForDerecognitionOfFinancialInstrumentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-407": {
   "value": "Inventories Inventories are stated at the lower of cost and net realisable value. Cost is determined using the weighted average method. It excludes borrowing costs. Net realisable value is the estimated selling price in the ordinary course of business, less applicable variable selling expenses. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForMeasuringInventories",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-408": {
   "value": "Trade receivables Trade receivables are recognised initially at the transaction price as these assets do not have signi\ufb01cant \ufb01nancing components, and are subsequently measured at amortised cost. The Group recognises loss allowances for receivables under the expected credit loss model as established by evidence that the Group will not be able to collect all amounts due according to the original terms of the receivables. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-409": {
   "value": "Cash and cash equivalents Cash and cash equivalents include cash in hand, bank deposits repayable on demand, and other short term highly liquid investments with original maturities of three months or less. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyToDetermineComponentsOfCashAndCashEquivalents",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-410": {
   "value": "Deposits Deposits consist of amounts held in escrow and is included within other receivables within the Statement of \ufb01nancial position until such time as the restrictions relating to those amounts have been lifted. ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DescriptionOfAccountingPolicyForDeposits",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-411": {
   "value": "Trade payables Trade payables are recognised initially at fair value and subsequently measured at amortised cost using the effective interest method. Trade payables are classi\ufb01ed as current liabilities if payment is due within one year or less. If not, they are presented as non-current liabilities. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForTradeAndOtherPayablesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-412": {
   "value": "Contract liabilities Contract liabilities primarily relate to the advance consideration received from clients for commercial development work and bioprocessing batches, as well as options and funded research and development activities. ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DescriptionOfAccountingPolicyForContractLiabilities",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-413": {
   "value": "Deferred income Deferred income primarily relates to the advance consideration received for grants and lease incentives. ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DescriptionOfAccountingPolicyForDeferredIncome",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-414": {
   "value": "Provisions Provisions for dilapidation costs and other potential liabilities are recognised when the Group has a present legal or constructive obligation as a result of past events; it is probable that an out\ufb02ow of resources will be required to settle the obligation; and the amount has been reliably estimated. Provisions are not recognised for future operating losses. Provisions are measured at the present value of the expenditure expected to be required to settle the obligation using the 3 year historic in\ufb02ation rate. The increase in the provision due to the passage of time is recognised as a \ufb01nance cost. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForProvisionsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-415": {
   "value": "Share capital Ordinary shares are classi\ufb01ed as equity. Costs of share issues are charged to the share premium account. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForIssuedCapitalExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-416": {
   "value": "Merger reserve A merger reserve is used where more than 90% of the shares in a subsidiary are acquired and the consideration includes the issue of new shares by the Company, thereby attracting merger relief under s612 and s613 of the Companies Act 2006. ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DescriptionOfAccountingPolicyForMergerReserve",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-417": {
   "value": "Business combinations The Group accounts for business combinations using the acquisition method when the acquired set of activities and assets meets  the de\ufb01nition of a business and control is transferred to the Group. In determining whether a particular set of activities and assets is a  business, the Group assesses whether the set of assets and activities acquired includes, at a minimum, an input and substantive process,  and whether the acquired set has the ability to produce outputs. The Group has an option to apply a \u2019concentration test\u2019 that permits  a simpli\ufb01ed assessment of whether an acquired set of activities and assets is not a business. The optional concentration test is met if  substantially all of the fair value of the gross assets acquired is concentrated in a single identi\ufb01able asset or group of similar identi\ufb01able  assets. The consideration transferred in the acquisition is generally measured at fair value, as are the identi\ufb01able net assets acquired.  Any goodwill that arises is tested annually for impairment. Any gain on a bargain purchase is recognised in pro\ufb01t or loss immediately.  Transaction costs are expensed as incurred, except if related to the issue of debt or equity securities. The consideration transferred does not include amounts related to the settlement of pre-existing relationships. Such amounts are  generally recognised in pro\ufb01t or loss. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-418": {
   "value": "Non-controlling interests (NCI) NCI are measured initially at the Group\u2019s proportionate interest in the recognised amount of the identi\ufb01able assets and liabilities of the  acquiree. NCI are measured subsequently at their proportionate share of the subsidiary\u2019s net assets at the reporting date. Changes in the  Group\u2019s interest in a subsidiary that do not result in a loss of control are accounted for as equity transactions. When a foreign operation is disposed of in its entirety, or partially such that control, signi\ufb01cant control or joint control, is lost, the  cumulative amount in the translation reserve related to the foreign operation is reclassi\ufb01ed to pro\ufb01t or loss as part of the gain or loss on  disposal. If the Group disposes of part of its interest in a subsidiary but retains control, then the relevant proportion of the cumulative  amount is reattributed to NCI. When the Group disposes of only part of an associate or joint venture while retaining signi\ufb01cant in\ufb02uence  or joint control, the relevant proportion of the cumulative amount is reclassi\ufb01ed to pro\ufb01t or loss. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-419": {
   "value": "Financial liability: loans  On initial recognition, external loans are measured at fair value plus directly attributable transaction costs. On subsequent measurement,  external loans are measured at amortised cost under the effective interest rate method. The effective interest rate method is a method  of calculating the amortised cost of a \ufb01nancial liability and allocating the interest expense over the relevant period. The calculation of the  effective interest rate takes into account the estimated cash \ufb02ows which consider all the contractual terms of the \ufb01nancial instrument,  including any embedded derivatives which are not subject to separation.  Financial liability: Put Options Where a put option with non-controlling shareholders (NCI) exists on their equity interests, a liability for the fair value of the exercise price  of the option is recognised.  Management have assessed that the NCI still have access to the returns associated with the underlying ownership interests, and have  therefore chosen to apply the present access method under which the corresponding entry is recognised in Other Equity. As required by  IFRS, Oxford Biomedica has chosen to apply an accounting policy, to be applied consistently for all put liabilities: that subsequent to initial  recognition, changes in fair value of the put liability will be recognised in equity.  The value of the put liability is determined using a Monte Carlo simulation which calculates the expected future exercise value of the put  option, taking into consideration Oxford Biomedica Solutions\u2019 forecasted cash \ufb02ows over the period up until the expected exercise date  along with the expected volatility of those cash \ufb02ows over that same period. The expected future exercise value is then discounted to the present using a discount rate in order to capture the counter party risk of the expected payment. The discount rate may be impacted  by economic and market factors as well as changes to the risk free rate of return which impacts debt borrowing rates. ",
   "dimensions": {
    "concept": "ifrs-full:DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-420": {
   "value": "2, Critical accounting judgements and estimates In applying the Group\u2019s accounting policies, management is required to make judgements and assumptions concerning the future in  a number of areas. Actual results may be different from those estimated using these judgements and assumptions. The key sources of  estimation uncertainty and the critical accounting judgements that have a signi\ufb01cant risk of causing a material adjustment to the carrying  amounts of assets and liabilities within the next \ufb01nancial year are discussed below. Key accounting matters Judgements Contract revenues: Identi\ufb01cation of performance obligations, allocation of revenue and timing of revenue recognition The Group has identi\ufb01ed three key areas of judgement within the collaboration agreements entered into during the period. Firstly, in relation to the number of distinct performance obligations contained within each collaboration agreement; secondly the fair value allocation of revenue to each performance obligation; and thirdly the timing of revenue recognition based on the achievement of the relevant performance obligation. The sales royalties contained within the collaboration agreements qualify for the royalty exemption available under IFRS 15 and will only be recognised as the underlying sales are made even though the performance obligation, in terms of the technology licence, has already been met. The judgements with regards to the number of distinct performance obligations and the fair value allocation of revenue to each performance obligation takes place on a contract-by-contract basis across numerous contracts entered into by the Group. As these judgements take place across numerous contracts, each with different characteristics, it is not practical to provide a quantitative analysis of the impact of applying different judgements, and the Directors do not believe that disclosing a range of outcomes resulting from applying different judgements provides meaningful information to the reader of the \ufb01nancial statements. Consequently, no quantitative analysis has been provided for these judgements. Number of distinct performance obligations Upon review of certain client contracts and preparation of accounting papers setting out the accounting treatment as per IFRS 15, the Group is required to exercise judgement in identifying the distinct performance obligations contained within the contract. These have been identi\ufb01ed as being: \u2014 The granting of technology licences \u2014 Milestones relating to bioprocessing or process development activities The fair value allocation of revenue to each performance obligation Because there is no readily available market price for many of the performance obligations contained in the client contracts, the Group exercises judgment in estimating the stand alone selling price of each of these performance obligations. Key areas of judgement are assessed to be: \u2014 The stand alone selling price of technology licences. The Group assesses the stand alone selling price of licences by reference to the stand alone selling price of previously recognised client technology licences, and the size of the market of the target indication and other market related observable inputs \u2014 The stand alone selling price of bioprocessing batches. The Group assesses the stand alone selling price of the batches in terms the stand alone selling price of its other client contract batch selling prices \u2014 The stand alone selling price in terms of the annual full time equivalent rate to charge for process development activities. The Group assesses the full time equivalent rate in terms the stand alone equivalent rate of its other client contract equivalent rates Timing of revenue recognition: technology licence revenues One of the key judgemental areas identi\ufb01ed within the collaboration agreements is the timing of recognition of licence revenue based on the achievement of the relevant performance obligation. The individual factors and aspects relating to licence revenue are assessed as part of the IFRS 15 accounting paper prepared for each agreement and a judgement is made as to whether the licence fee performance obligation related to the granting of the licence to the client has been achieved. If it was judged that the performance obligations on licences granted in 2022 had not been met, revenues would have been \u00a33,385,000 lower with the revenue expected to be recognised in future when the performance obligations were deemed to have been met. Modi\ufb01cation of Oaktree loan agreement When a loan agreement with an existing lender is modi\ufb01ed, a determination has to be made as to whether the modi\ufb01cation is treated as the extinguishment of the existing \ufb01nancial liability and the recognition of a new liability, or accounting for the modi\ufb01cation of the agreement as a modi\ufb01cation to the existing \ufb01nancial liability. On 10 March 2022 the Group entered into and drew down an US$85 million loan facility agreement with Oaktree under a 1 year facility agreement maturing in 2023 with a nominal interest rate on the loan of 8.5%. On 7 October 2022, the Loan Agreement was amended, US$35 million was repaid and the term extended to October 2026, with a variable interest rate which is capped at 10.25% per annum. A substantial modi\ufb01cation under IFRS 9 is deemed to have occurred if the net present value of the cash \ufb02ows under the new terms, including any fees, differs by at least 10% from the present value of the remaining cash\ufb02ows under the original terms. Management has determined that the modi\ufb01cation of the Oaktree loan agreement on 7 October 2022 does not meet the substantial modi\ufb01cation criteria and therefore will be recognised as a non-substantial modi\ufb01cation to the existing loan, with the loan being restated to its present value and subsequently at amortised cost under the effective interest rate method. This was determined on the basis of the quantitative test performed as required by IFRS 9 resulting in a 3% change to the net present  value of the remaining cash \ufb02ows when compared to the original cash \ufb02ows under the original terms. Management has also performed  a qualitative assessment to identify substantial differences in terms that by nature were not captured by the quantitative assessment.  In considering the qualitative factors, Management has considered the payment terms, options, change in other terms and collaterals.  Based on the quantitative and qualitative assessment, Management has determined that the modi\ufb01cation of the loan does not meet the  substantial modi\ufb01cation criteria. If the Group had concluded that the amendment constitutes a signi\ufb01cant modi\ufb01cation, this accounting treatment would have resulted in the recognition of a loss on extinguishment of \u00a31,391,000, recognition of legal fees of \u00a3439,000, and an increase in the loan balance of \u00a3409,000 on the 7th of October 2022. Estimations The key assumptions concerning the future and other key sources of estimation uncertainty at the reporting date that have a signi\ufb01cant  risk of causing a material adjustment to the carrying amounts of assets and liabilities within the next \ufb01nancial year are discussed below.  The nature of estimation means that actual outcomes could differ from those estimates. Percentage of completion of bioprocessing batch revenues Bioprocessing of clinical/commercial product for clients is recognised on a percentage of completion basis over time as the processes are carried out. Progress is determined based on the achievement of veri\ufb01able stages of the bioprocessing process. Revenues are recognised on a percentage of completion basis and as such require estimation in terms of the assessment of the correct stage of completion including the expected costs to completion for that speci\ufb01c bioprocessing batch. The value of the revenue recognised with regard to the bioprocessing batches which remain in progress at year end is \u00a3 32,051,000. If the assessed percentage of completion was 10 percentage points higher or lower, revenue recognised in the period would have been \u00a3 3,866,000 higher or lower.Percentage of completion of \ufb01xed price process development revenues As it satis\ufb01es its performance obligations the Group recognises revenue and the related contract asset with regard to \ufb01xed price process  development work packages. Revenues are recognised on a percentage of completion basis and as such require estimation in terms of  the assessment of the correct percentage of completion for that speci\ufb01c process development work package. The value of the revenue  recognised raised with regard to the work packages which remain in progress at year end is \u00a38,179,000. If the assessed percentage of completion was 10 percentage points higher or lower, revenue recognised in the period would have been \u00a3818,000 higher or lower. Provision for out of speci\ufb01cation bioprocessing batches Bioprocessing of clinical/commercial product for clients is recognised on a percentage of completion basis over time as the processes  are carried out. Progress is determined based on the achievement of veri\ufb01able stages of the process. As Oxford Biomedica (UK) Ltd has now been bioprocessing product across a number of years, and also in a commercial capacity,  Oxford Biomedica (UK) Ltd has assessed the need to include an estimate of bioprocessed product for which revenue has previously been  recognised and which may be reversed should the product go out of speci\ufb01cation during the remaining period over which the product is bioprocessed. In calculating this estimate Oxford Biomedica (UK) Ltd has looked at historical rates of out of speci\ufb01cation batches across  the last four years, and has applied the percentage of out of speci\ufb01cation batches to total batches produced across the assessed period to  the revenue recognised on batches which have not yet completed the bioprocessing process at year end. This estimate, based on the historical percentage, may be signi\ufb01cantly higher or lower depending on the number of bioprocessing batches actually going out of speci\ufb01cation in future. If the historical percentage had been 10% higher or lower, the estimate would be \u00a3259,000 higher or lower. The estimate will increase or decrease based on the number of bioprocessing batches undertaken, the percentage of completion of those bioprocessing batches, and the number of batches which go out of speci\ufb01cation over the assessment period. Consequently, bioprocessing revenue of \u00a32,592,000 (2021: \u00a3769,000) has not been recognised during 2022, with the corresponding  credit to contract liabilities (note 19). This revenue will be recognised as the batches complete bioprocessing. No provision for out of speci\ufb01cation batches has been raised for Oxford Biomedica Solutions as management has concluded that,  based on review of analytical testing results received after year end, no bioprocessing batch was deemed to be at risk of failure to meet  speci\ufb01cations. Amortisation of intangibles assets (developed technology) The estimated useful life of developed technology acquired by the Group is 15 years as the Group expects the technology to generate  cash \ufb02ows for a total of 15 years. The estimate of 15 years is based on management\u2019s experience of the time period over which the  technology acquired as part of the acquisition of Oxford Biomedica Solutions will become fully obsolete. Over time as the platform  technology is improved, parts of the technology become obsolete as they are superseded by new technology until after 15 years the  original technology is expected to have been fully replaced by newer/improved technology.  If the estimated useful life of the assets had been 10 years, the estimated amortisation for the year ended 31 December 2022 would be  \u00a33,036,000 higher (2021: nil); whilst, if the estimated useful life of the assets had been 20 years, the estimated amortisation for the year  ended 31 December 2022 would be \u00a31,518,000 lower (2021:nil). Sale and leaseback \u2013 Lease liability discount rate During November 2022 the Group sold its Windrush Court facility property to Kadans for a cash consideration of \u00a360 million in a sale and leaseback transaction (refer note 33). A key estimate identi\ufb01ed by the Group within the sale and leaseback agreement is the incremental borrowing rate used to discount the lease liability cash \ufb02ows back to their present value to determine the lease liability at year end. Since the rate implicity in the lease is not readily determinable, the Group's incremental borrowing rate has been used (the rate of interest that would have to be paid to borrow on a collateralised basis over a similar term for an amount equal to the lease payments in a similar economic environment) based on the information available at commencement date in determining the discount rate used to calculate the present value of lease payments. The rates have been determined using previously available information on borrowing rates as well as indicative borrowing rates that would be available based on the value, currency and borrowing term provided by \ufb01nancial institutions, adjusted for company and market speci\ufb01c factors. Estimation of uncertainty is involved in selecting an appropriate rate, and the rate selected for each lease will have an impact on the value of the lease liability and corresponding right-of-use (ROU) asset in the Consolidated Statement of \ufb01nancial positions. If the estimated lease liability discount rate had been one percentage higher or lower, the gain recognised on the sale of Windrush court would have been \u00a31,775,000 higher or lower (2021: \u00a3nil) with the other side of the entry decreasing or increasing the lease liability by a \u00a32,027,000 (2021: \u00a3nil) and decreasing and increasing right of use assets by a \u00a3253,000 (2021: \u00a3nil). Valuation of put option liability Where a put option with non-controlling shareholders exists on their equity interests, a liability for the fair value of the exercise price of the option is recognised. On 10 March 2022, the Group recognised a put option liability to acquire the remaining 20% of Oxford Biomedica Solutions that it doesn\u2019t already own, from Homology Medicines. The fair value of the option at the date of acquisition was assessed to be \u00a339.0 million. At 31 December 2022 the fair value of the put option liability was \u00a338.2 million (Dec 2021: \u00a3nil). The Group estimates the value of the put liability using a Monte Carlo simulation which calculates the expected future exercise value of the put option, taking into consideration Oxford Biomedica Solutions\u2019 forecasted revenues over the period up until the expected exercise date along with the expected volatility of those revenues over that same period. The expected future exercise value is then discounted to the present using a discount rate in order to capture the counter party risk of the expected payment. Key estimation uncertainty inputs which directly impact the valuation of the put option liability are assessed to be: \u2014 Revenues of Oxford Biomedica Solutions \u2013\u2009the revenues of Oxford Biomedica Solutions are based on the management approved forecast up until the end of the option period. Should the forecast change or the actual results vary this may impact the value of the put option liability.  \u2014 Expected volatility of revenues \u2013 should the expected volatility of Oxford Biomedica Solutions revenues vary, this may impact the value of the put option liability, \u2014 Discount rate \u2013 the discount rate may be impacted by economic and market factors, as well as changes to the risk free rate of return which impacts debt borrowing rates. Should the discount rate calculated by management be adjusted, this may impact the value of the put option. Management has calculated the discount rate based on the risk free rate, the expected return from similar companies and the Group\u2019s cost of debt. Fair value Put option liability  31 December 2022      Increase Decrease Effect in thousands of pounds: Revenues of Oxford Biomedica Solutions: 10% higher or lower 2.1 (2.4) Discount rate 2% lower or higher 1.4 (1.4) Valuation of acquired intangible assets As part of the acquisition accounting for the acquisition of Oxford Biomedica Solutions LLC in 2022, we have performed an assessment  on the identi\ufb01cation, fair value, and expected useful economic lives of acquired intangible assets such as developed technology assets  at the date of acquisition. The fair value attributed to intangible assets arising on acquisition is recognised in accordance with IAS 38  Intangible assets and is based on a number of estimates. The acquired identi\ufb01able assets and liabilities have been recognised at their fair values at acquisition date and in accordance with the  Group\u2019s accounting policies. The fair value of the developed technologies intangible asset is considered a key estimate subject to  estimation uncertainty. Below are the details for the valuation methodologies used for the intangible assets. Acquired developed technology has been valued using the multi-period excess earnings method (MPEEM) method, valued at  \u00a3102.8 million, The MPEEM method considers the present value of net cash \ufb02ows expected to be generated by the client relationships,  by excluding any cash \ufb02ows related to contributory assets. Management considers the weighted average return on assets and discount rates as critical estimates as a reasonably possible change  to these assumptions in aggregation, or in isolation, will have an impact on the consolidated \ufb01nancial statements. The weighted average  return on assets and discount rate used by management in the valuation of the developed technology is 17.3% and 20% respectively.  Below are the various sensitivities of weighted average return on assets and discount rates and their impact on the related  intangible assets. Sensitivities Discount rate Weighted average  rate of return Adjusted Developed technology value \u00a3\u2019m Impact \u00a3\u2019m 17% 15.0% 121.8 19.0 18% 15.8% 113.5 10.7 19% 16.5% 106.0 3.2 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfAccountingJudgementsAndEstimatesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-421": {
   "value": "3, Financial risk management  Financial risk factors The Group has a simple corporate structure which consists of the Company and two main operating subsidiaries, one domiciled in  the UK and the other in the US. Monitoring of \ufb01nancial risk is part of the Board\u2019s ongoing risk management, the effectiveness of which  is reviewed annually. The Group\u2019s agreed policies are implemented by the Chief Financial Officer, who submits reports at each Board  meeting. The Group does not use \ufb01nancial derivatives, and it is the Group\u2019s policy not to undertake any trading in \ufb01nancial instruments. (a) Foreign exchange risk In 2022 the Group\u2019s revenues were mostly receivable in Sterling and US Dollars, and certain of its expenditures were payable in Euros  and US Dollars. The majority of the UK based entities\u2019 operating costs are denominated in Sterling. A 10% difference in the \u00a3/$ average  exchange rate would have had an impact of approximately \u00a31,121,000 (2021: \u00a3712,000) over the year. The US based entities\u2019 revenue and operating costs are all in USD. The Group also has exposure to the \u00a3/$ exchange rate due to the Oaktree loan facility denominated in Dollars. Had the \u00a3/$ exchange rate  been 10% different, the impact on cost in 2022 would have been approximately \u00a3455,000 (2021: nil).  The Group also has exposure to the \u00a3/\u20ac exchange rate due to the need to fund certain expenditure denominated in Euros. Had the average \u00a3/\u20ac exchange rate been 10% different, the impact on cost in 2022 would have been approximately \u00a3418,000 (2021: \u00a3305,000). The Group\u2019s policy is to hold the majority of its funds in Sterling and US Dollars. No other hedging of foreign currency cash \ufb02ows is undertaken.(b) Interest rate risk The Group\u2019s policy is to maximise interest receivable on deposits, subject to maintaining access to sufficient liquid funds to meet day to day operational requirements and preserving the security of invested funds. With the current low level of bank interest rates at the start  of the year, interest receivable on bank deposits in 2022 was just \u00a3973,000 (2021: \u00a3nil). On 10 March 2022, the Group drew down an US$85 million loan facility with Oaktree to \ufb01nance the acquisition of Oxford Biomedica  Solutions, under a 1 year facility agreement maturing in 2023. On 7 October 2022, the loan facility was re\ufb01nanced with Oaktree. Under  the terms of such re\ufb01nancing, the Company has partially repaid the outstanding amounts under the Short-Term Loan Facility and  amended the facility into a new senior secured four year term loan facility provided by Oaktree in a principal amount of US$50 million.  The Term Loan carries a variable interest rate, which is capped at 10.25% per annum and payable quarterly in cash, with up to 50% of  interest for the \ufb01rst twelve months payable in kind as additional loan principal, at the option of the Company. The interest rate is subject to downward adjustment following the satisfaction of certain commercial conditions. If interest rates had been 1% higher in 2022 the impact on cash interest paid would have been \u00a3nil (2022: \u00a3nil). (c) Credit risks Cash balances are mainly held on short term deposits with \ufb01nancial institutions with a credit rating of at least A, in line with the Group\u2019s  policy to minimise the risk of loss. Trade debtors are monitored to minimise the risk of loss (note 16). Derivative \ufb01nancial instruments and hedging There were no material derivatives at 31 December 2022 or 31 December 2021 which have required separation, and hedge accounting has not been used. Fair value estimates The fair value of short term deposits with a maturity of one year or less is assumed to be the book value. Capital Management The Group\u2019s objectives when managing capital are to safeguard the Group\u2019s ability to continue as a going concern in order to provide returns to shareholders and bene\ufb01ts for other stakeholders, and to maintain an optimal capital structure to minimise the cost of capital. Group 2022 \u00a3\u2019000 2021  \u00a3\u2019000 Net (cash)/debt\u2009\u00b2 (101,505) (108,944)\u2009\u00b9 Equity 236,192 187,338 Debt/equity 43% (58%) \u00b9   Represents Cash balance only as no debt. \u00b2  Net (cash)/debt is Cash and cash equivalents less Loans as outlined on page 136. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFinancialRiskManagementExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-456": {
   "value": "(a) Foreign exchange risk In 2022 the Group\u2019s revenues were mostly receivable in Sterling and US Dollars, and certain of its expenditures were payable in Euros  and US Dollars. The majority of the UK based entities\u2019 operating costs are denominated in Sterling. A 10% difference in the \u00a3/$ average  exchange rate would have had an impact of approximately \u00a31,121,000 (2021: \u00a3712,000) over the year. The US based entities\u2019 revenue and operating costs are all in USD. The Group also has exposure to the \u00a3/$ exchange rate due to the Oaktree loan facility denominated in Dollars. Had the \u00a3/$ exchange rate  been 10% different, the impact on cost in 2022 would have been approximately \u00a3455,000 (2021: nil).  The Group also has exposure to the \u00a3/\u20ac exchange rate due to the need to fund certain expenditure denominated in Euros. Had the average \u00a3/\u20ac exchange rate been 10% different, the impact on cost in 2022 would have been approximately \u00a3418,000 (2021: \u00a3305,000). The Group\u2019s policy is to hold the majority of its funds in Sterling and US Dollars. No other hedging of foreign currency cash \ufb02ows is undertaken.(b) Interest rate risk The Group\u2019s policy is to maximise interest receivable on deposits, subject to maintaining access to sufficient liquid funds to meet day to day operational requirements and preserving the security of invested funds. With the current low level of bank interest rates at the start  of the year, interest receivable on bank deposits in 2022 was just \u00a3973,000 (2021: \u00a3nil). On 10 March 2022, the Group drew down an US$85 million loan facility with Oaktree to \ufb01nance the acquisition of Oxford Biomedica  Solutions, under a 1 year facility agreement maturing in 2023. On 7 October 2022, the loan facility was re\ufb01nanced with Oaktree. Under  the terms of such re\ufb01nancing, the Company has partially repaid the outstanding amounts under the Short-Term Loan Facility and  amended the facility into a new senior secured four year term loan facility provided by Oaktree in a principal amount of US$50 million.  The Term Loan carries a variable interest rate, which is capped at 10.25% per annum and payable quarterly in cash, with up to 50% of  interest for the \ufb01rst twelve months payable in kind as additional loan principal, at the option of the Company. The interest rate is subject to downward adjustment following the satisfaction of certain commercial conditions. If interest rates had been 1% higher in 2022 the impact on cash interest paid would have been \u00a3nil (2022: \u00a3nil). ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfMarketRiskExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-457": {
   "value": "(c) Credit risks Cash balances are mainly held on short term deposits with \ufb01nancial institutions with a credit rating of at least A, in line with the Group\u2019s  policy to minimise the risk of loss. Trade debtors are monitored to minimise the risk of loss (note 16). Assessment of \ufb01nancial assets by credit risk rating: Cash and cash equivalents are held with reputable banks with a low assessed risk of default. All trade receivables are assessed as having a low credit risk rating as the debt is owed by blue chip pharmaceutical groups in the top 10  in the world by market capitalisation, and by biotechnology companies with sufficient cash reserves to satisfy their obligations. There  has been no change in the determined risk during 2022, therefore no reconciliation between the 2021 and 2022 closing debtor balance  assessed by risk of default has been provided. The opening and closing position was low (2021: low). Other receivables are rent deposits held in separately administered bank accounts with covenants limiting their use and are as such  assessed as having a low risk of default. The Group considers a \ufb01nancial asset to be in default when:  \u2014 The debtor is unlikely to pay its credit obligation to the Group in full, without recourse by the Group to actions such as realising  security (if any is held); or   \u2014 the \ufb01nancial asset is more than 90 days past its contracted due date. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfCreditRiskExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-458": {
   "value": "Derivative \ufb01nancial instruments and hedging There were no material derivatives at 31 December 2022 or 31 December 2021 which have required separation, and hedge accounting has not been used. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfDerivativeFinancialInstrumentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-459": {
   "value": "Fair value estimates The fair value of short term deposits with a maturity of one year or less is assumed to be the book value. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFairValueMeasurementExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-460": {
   "value": "Capital Management The Group\u2019s objectives when managing capital are to safeguard the Group\u2019s ability to continue as a going concern in order to provide returns to shareholders and bene\ufb01ts for other stakeholders, and to maintain an optimal capital structure to minimise the cost of capital. Group 2022 \u00a3\u2019000 2021  \u00a3\u2019000 Net (cash)/debt\u2009\u00b2 (101,505) (108,944)\u2009\u00b9 Equity 236,192 187,338 Debt/equity 43% (58%) \u00b9   Represents Cash balance only as no debt. \u00b2  Net (cash)/debt is Cash and cash equivalents less Loans as outlined on page 136. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfObjectivesPoliciesAndProcessesForManagingCapitalExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-422": {
   "value": "4, Segmental analysis Segmental reporting The chief operating decision-maker has been identi\ufb01ed as the Senior Executive Team (SET), comprising the Executive Directors, Chief Commercial Officer, Chief Technical Officer, Chief Scienti\ufb01c Officer, Chief Business and Corporate Development Officer, Chief Operations Officer, Chief People Officer, Chief Information Officer and General Counsel. The SET monitors the performance of the Group in two business segments:(i)  Platform \u2013 this segment consists of the revenue generating bioprocessing and process development activities undertaken for third parties (i.e the partner programmes LentiVector \u00ae and AAV CDMOs business). It also includes internal technology developments and technical intellectual property within the LentiVector\u00ae platform. (ii)  Product \u2013 this segment consists of the clinical and pre-clinical development of in vivo and ex vivo cell and gene therapy products (gene therapeutics) which are owned by the Group. In the \ufb01rst quarter of 2023, the SET has re-assessed the reporting segments to re\ufb02ect the way the business will be managed in future. Management reporting is currently being reworked to align with these new segments going forward and the Group expects to be able to report on these new segments during 2023 and thereafter. No changes from the current basis have been re\ufb02ected in the 2022 Annual report and accounts. Revenues, other operating income and operating loss by segment Revenues, Operating EBITDA and Operating pro\ufb01t/(loss) represent the Group\u2019s measures of segment pro\ufb01t and loss as they are a primary measure used for the purpose of making decisions about allocating resources and assessing performance of segments. 2022 Platform  \u00a3\u2019000 Product  \u00a3\u2019000 Total  \u00a3\u2019000 Revenue 139,903 86 139,989 Other operating income 2,307 \u2013 2,307 Gain on sale and leaseback 21,389  \u2013 21,389 Operating EBITDA\u00b9 11,654 (10,023) 1,631 Depreciation, amortisation and share based payment (29,551) (2,250) (31,801) Operating loss (17,948) (12,272) (30,220) Net \ufb01nance cost (15,756) Loss before tax (45,976) 2021 Platform  \u00a3\u2019000 Product  \u00a3\u2019000 Total  \u00a3\u2019000 Revenue 142,693 104 142,797 Other operating income 867 \u2013 867 Operating EBITDA\u00b9 45,292 (9,368) 35,924 Depreciation, amortisation and share based payment (13,702) (1,288) (14,990) Revaluation of investments (165) \u2013 (165) Operating pro\ufb01t/(loss) 31,425 (10,657) 20,768 Net \ufb01nance cost (888) Pro\ufb01t before tax 19,880 \u00b9   Operating EBITDA (Earnings Before Interest, Tax, Depreciation, Amortisation, revaluation of investments and Assets at fair value through pro\ufb01t and loss, and Share Based Payments) is a non-GAAP measure often used as a surrogate for operational cash \ufb02ow as it excludes from operating pro\ufb01t or loss all non-cash items, including the charge for share based payments options. A reconciliation to GAAP measures is provided on page 34. Other operating income of \u00a32.3 million (2021: \u00a30.9 million) includes sub lease rental income of \u00a31.4 million (2021: Nil) in relation to a  portion of the Patriot\u2019s Park property in the US accounted for as a as a short term lease, and grant income to further develop our supply  chain capabilities of \u00a30.9 million (2021: \u00a30.9 million) and is included within the Platform segment. Costs are allocated to the segments on a speci\ufb01c basis as far as possible. Costs which cannot readily be allocated speci\ufb01cally are  apportioned between the segments using relevant metrics such as headcount or direct costs. No intangible assets or \ufb01xed assets of any signi\ufb01cant value have been assessed to be assigned speci\ufb01cally to the Products division, and  therefore no impairment has been required as a result of the decision by the Group to look for alternative funding for the Product division. A segmental or geographical split of assets and liabilities is not provided because this information is not received or reviewed by the chief  operating decision-maker. All assets are located within the United Kingdom and United States. Disaggregation of revenue Revenue is disaggregated by the type of revenue which is generated by the commercial arrangement. 2022 Platform  \u00a3\u2019000 Product  \u00a3\u2019000 Total  \u00a3\u2019000 Bioprocessing/Commercial development 127,994 86 128,080 Licence fees, milestones and royalties 11,909 \u2013 11,909 Total 139,903 86 139,989 2021 Platform  \u00a3\u2019000 Product  \u00a3\u2019000 Total  \u00a3\u2019000 Bioprocessing/Commercial development 128,318 104 128,422 Licence fees, milestones and royalties 14,375 \u2013 14,375 Total 142,693 104 142,797 Timing of transfer of goods or services 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Products and services transferred at a point of time 11,909 13,997 Products and services transferred over time 128,080 128,800 Total revenue 139,989 142,797 The majority of the Group\u2019s revenue is typically recognised over time as the performance obligations in the contract are being ful\ufb01lled. Results by geographical location The Group\u2019s revenue derives wholly from assets located in the United Kingdom and the United States. Analysed by location the Group\u2019s  revenues derive predominantly from United Kingdom, United States, Europe and the rest of the world: Revenue by client location 2022 \u00a3\u2019000 2021 \u00a3\u2019000 United Kingdom 49,939 97,063 United States 61,591 20,816 Europe 28,063 21,632 Rest of world 396 3,286 Total revenue 139,989 142,797 In 2022 \ufb01ve clients each provided 10% or more of the Group\u2019s revenues in the platform segment. Geographic split of operating loss 2022 \u00a3\u2019000 2021 \u00a3\u2019000 United Kingdom (1,465) (20,768) United States (28,755) \u2013 Total operating loss (30,220) (20,768) Geographic split of non current assets 2022 \u00a3\u2019000 2021 \u00a3\u2019000 United Kingdom 94,997 73,385 United States 149,679 \u2013 Total non current assets 244,676 73,385 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfEntitysReportableSegmentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-461": {
   "value": "Results by geographical location The Group\u2019s revenue derives wholly from assets located in the United Kingdom and the United States. Analysed by location the Group\u2019s  revenues derive predominantly from United Kingdom, United States, Europe and the rest of the world: Revenue by client location 2022 \u00a3\u2019000 2021 \u00a3\u2019000 United Kingdom 49,939 97,063 United States 61,591 20,816 Europe 28,063 21,632 Rest of world 396 3,286 Total revenue 139,989 142,797 In 2022 \ufb01ve clients each provided 10% or more of the Group\u2019s revenues in the platform segment. Geographic split of operating loss 2022 \u00a3\u2019000 2021 \u00a3\u2019000 United Kingdom (1,465) (20,768) United States (28,755) \u2013 Total operating loss (30,220) (20,768) Geographic split of non current assets 2022 \u00a3\u2019000 2021 \u00a3\u2019000 United Kingdom 94,997 73,385 United States 149,679 \u2013 Total non current assets 244,676 73,385 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfGeographicalAreasExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-423": {
   "value": "5, Employees and directors The monthly average number of persons (including Executive Directors) employed by the Group during the year was: By activity 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Office and management 117 56 Research, development and bioprocessing 812 703 Total 929 759 Employee bene\ufb01t costs 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Wages and salaries 70,042 43,174 Social security costs 6,165 5,122 Other pension costs (note 32) 3,560 2,839 Share based payments (note 28) 6,471 3,523 Total employee bene\ufb01t costs 86,238 54,658 Key management compensation 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Wages and salaries 4,486 3,167 Social security costs 760 893 Other pension costs 293 250 Share based payments 2,620 2,075 Total 8,159 6,385 The key management \ufb01gures above include Executive and Non-Executive Directors and the other members of the SET. Further information about the remuneration of individual Directors, including the highest paid Director, is provided in the audited part of the Directors\u2019 Remuneration Report on page 95 which forms part of these \ufb01nancial statements. The Company had no employees during the year (2021: zero). ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfInformationAboutEmployeesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-462": {
   "value": "2022 \u00a3\u2019000 2021 \u00a3\u2019000 Wages and salaries 4,486 3,167 Social security costs 760 893 Other pension costs 293 250 Share based payments 2,620 2,075 Total 8,159 6,385 The key management \ufb01gures above include Executive and Non-Executive Directors and the other members of the SET. Further information about the remuneration of individual Directors, including the highest paid Director, is provided in the audited part of the Directors\u2019 Remuneration Report on page 95 which forms part of these \ufb01nancial statements. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfInformationAboutKeyManagementPersonnelExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-479": {
   "value": "6, Finance income and costs Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Finance income: Bank interest receivable   973 \u2013 \u2013 \u2013 Total \ufb01nance income  973  \u2013 \u2013 \u2013 Finance costs: Unwinding of discount in provisions (note 20) (66) (27) (28) \u2013 Gain on foreign exchange (7,975) \u2013 (7,964) \u2013 Interest payable on loans (5,564) \u2013 (5,564) \u2013 Interest payable on \ufb01nance leases (3,124) (861) (477) \u2013 Total \ufb01nance costs (16,729) (888) (14,033) \u2013 Net \ufb01nance costs (15,756) (888) (14,033) \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFinanceCostExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-463": {
   "value": "6, Finance income and costs Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Finance income: Bank interest receivable   973 \u2013 \u2013 \u2013 Total \ufb01nance income  973  \u2013 \u2013 \u2013 Finance costs: Unwinding of discount in provisions (note 20) (66) (27) (28) \u2013 Gain on foreign exchange (7,975) \u2013 (7,964) \u2013 Interest payable on loans (5,564) \u2013 (5,564) \u2013 Interest payable on \ufb01nance leases (3,124) (861) (477) \u2013 Total \ufb01nance costs (16,729) (888) (14,033) \u2013 Net \ufb01nance costs (15,756) (888) (14,033) \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFinanceIncomeExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-424": {
   "value": "6, Finance income and costs Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Finance income: Bank interest receivable   973 \u2013 \u2013 \u2013 Total \ufb01nance income  973  \u2013 \u2013 \u2013 Finance costs: Unwinding of discount in provisions (note 20) (66) (27) (28) \u2013 Gain on foreign exchange (7,975) \u2013 (7,964) \u2013 Interest payable on loans (5,564) \u2013 (5,564) \u2013 Interest payable on \ufb01nance leases (3,124) (861) (477) \u2013 Total \ufb01nance costs (16,729) (888) (14,033) \u2013 Net \ufb01nance costs (15,756) (888) (14,033) \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFinanceIncomeExpenseExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-425": {
   "value": "7, Expenses by nature Group Company Notes 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Employee bene\ufb01t costs 5 86,238 54,658 992 823 Depreciation of property, plant and equipment 12 20,271 12,435 323 \u2013 Amortisation 11 6,088 21  \u2013 \u2013 Raw materials and consumables used in  bioprocessing 27,449 23,026 \u2013 \u2013 Operating lease payments 231 236 \u2013 \u2013 Net loss on foreign exchange (751) (115) \u2013 \u2013 Company employee bene\ufb01t costs include \u00a3992,000 (2021: \u00a3823,000) relating to non-executive costs paid by Oxford Biomedica UK Ltd  and recharged to the Company. Depreciation is charged to cost of goods, research and development, and bioprocessing costs in the statement of comprehensive  income. Amortisation is charged to research and development in the statement of comprehensive income. The operating lease payments relate to short term leases which have been accounted for under the IFRS 16 exemption. During the year the Group (including its subsidiaries) obtained services from the Group\u2019s auditors and their associates as detailed below: Services provided by the Group\u2019s auditors 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Fees payable for the audit of the parent company and consolidated \ufb01nancial statements 50 50 Fees payable for other services: The audit of the Company\u2019s subsidiaries 895 350 Additional fees relating to prior year audit 98 70 Review of interim results 35 35 Total 1,078 505 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfExpensesByNatureExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-464": {
   "value": "During the year the Group (including its subsidiaries) obtained services from the Group\u2019s auditors and their associates as detailed below: Services provided by the Group\u2019s auditors 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Fees payable for the audit of the parent company and consolidated \ufb01nancial statements 50 50 Fees payable for other services: The audit of the Company\u2019s subsidiaries 895 350 Additional fees relating to prior year audit 98 70 Review of interim results 35 35 Total 1,078 505 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfAuditorsRemunerationExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-426": {
   "value": "8, Taxation During 2020 the Group ceased being eligible to claim a research and development tax credits under the Government\u2019s small company  scheme, and instead in 2021 and 2022 claimed under the Large Company scheme. Current tax 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Corporation tax (1,282) (1,427) (1,282) (1,427) Adjustments in respect of prior periods:    United Kingdom corporation tax research and development credit 307 558 Current tax (975) (869) Deferred tax    Relating to the origination of timing differences 1,792 \u2013  Deferred tax 1,792 \u2013  Taxation credit/(charge) 817 (869) U.K. income tax  The amount of \u00a31,282,000 (2021:\u00a31,427,000) included as part of the taxation charge within the statement of comprehensive income for  the year ended 31 December 2022 comprises the corporation tax payable on the amount claimed as a Large Company Tax credit (RDEC)  within research and development expenses in the statement of comprehensive income. The adjustment of current tax in respect of the prior year of \u00a3307,000 relates to the corporation tax credit on a lower than anticipated  RDEC tax receipt. In 2021 the adjustment in respect of prior years in the amount of \u00a3558,000 related to a SME tax credit received relating  to prior years. The United Kingdom corporation tax research and development (RDEC) credit which is included in research and development expenses,  is paid in arrears once tax returns have been \ufb01led and agreed. The tax credit recognised in the \ufb01nancial statements but not yet received is  included in trade and other receivables in the Statement of \ufb01nancial position. During 2022 the Group recognised \u00a3125,000 (2021: \u00a3458,000) of current tax relating to tax relief obtained on exercise of share options  directly within equity. The Company has no tax liability, nor is it entitled to tax credits (2021: \u00a3nil). At 31 December 2022, the Group had UK tax losses, with no expiry date, to be carried forward of approximately \u00a376.2 million (2021: \u00a378.3  million).  U.S. income tax Deferred tax of \u00a31,764,000 (2021: Nil) relates to temporary differences relating to intangible assets. At 31 December 2022, the Group had US tax losses to be carried forward of approximately \u00a37.3 million (2021: \u00a3nil) that expire 20 years from it being incurred. Reconciliation of effective tax rate The tax credit for the year is lower (2021: lower) than the standard rate of corporation tax in the UK. The differences are explained below: Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Loss/(pro\ufb01t) on ordinary activities before tax   (45,976) 19,880 (4,804) (2,366) Loss/(pro\ufb01t) on ordinary activities before tax multiplied by the standard rate of corporation tax in the UK of 19% (2021: 19%)  8,734 (3,777) 913 450 Effects of:  Expenses not deductible for tax purposes (1,985) (649) (28) (101) Income not taxable 376 344 1,272 \u2013 Transfer pricing adjustments (1,005) \u2013 (1,005) \u2013 Current tax relief less than accounting charge on share options (517) (174) \u2013 \u2013 Effects of group relief/other reliefs \u2013 \u2013 (158) (349) Deferred tax not recognised \u2013 2,829 579 \u2013 Amounts not recognised (4,753) \u2013 (1,573) \u2013 Rolled over gains (3,074) \u2013 \u2013 \u2013 Effects of overseas tax rates 2,734 \u2013 \u2013 \u2013 Adjustments in respect of prior periods 307 558 \u2013 \u2013 Total tax (charge)/credit for the year 817 (869) \u2013 \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfIncomeTaxExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-427": {
   "value": "9, Basic and diluted pro\ufb01t/(loss) per ordinary share The basic loss per share of 41.29p (2021: pro\ufb01t 22.77p) has been calculated by dividing the (loss)/pro\ufb01t for the period by the weighted average number of shares in issue during the year ended 31 December 2022 being, 94,829,892 (2021: 83,484,173). As the Group made a loss this year, there is therefore no difference between the basic loss per ordinary share and the diluted loss per ordinary share in the current period. The Group made a pro\ufb01t in the prior period and the diluted earnings per share in the year was 22.20p, which was calculated by dividing the earnings for the period by the weighted average number of shares in issue during the period after adjusting for the dilutive effect of the share options outstanding at 31 December 2021 (2,134,494). ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfEarningsPerShareExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-428": {
   "value": "10, Loss for the \ufb01nancial year As permitted by section 408 of the Companies Act 2006, the Company\u2019s statement of comprehensive income has not been included in these \ufb01nancial statements. The Company\u2019s loss for the year was \u00a34,804,000 (2021: \u00a32,366,000) ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DisclosureOfTheLossForTheFinancialYear",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-429": {
   "value": "11, Intangible assets Notes Goodwill \u00a3\u2019000 Developed technology \u00a3\u2019000 Patents \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2021 \u2013 \u2013 5,636 5,636 At 31 December 2021 \u2013 \u2013 5,636 5,636 At 1 January 2022 \u2013 \u2013 5,636 5,636 Acquisitions through business combinations 35 610 102,869 \u2013 103,479 Retirements \u2013 \u2013 (3,825) (3,825) Effects of movements in exchange rates 51 8,536 \u2013 8,587 At 31 December 2022 661 111,405 1,811 113,877 Accumulated amortisation and impairment At 1 January 2021 \u2013 \u2013 5,563 5,563 Charge for the year \u2013 \u2013 21 21 At 31 December 2021 \u2013 \u2013 5,584 5,584 At 1 January 2022 \u2013 \u2013 5,584 5,584 Charge for the year \u2013 6,072 16 6,088 Retirements \u2013 \u2013 (3,797) (3,797) Effects of movements in exchange rates \u2013 116 \u2013 116 At 31 December 2022 \u2013 6,188 1,803 7,991 Net book amount at 31 December 2022 661 105,217 8 105,886 Net book amount at 31 December 2021 \u2013 \u2013 52 52 Intangible assets comprise Goodwill, Developed Technology and Patents for intellectual property rights. The Group has not capitalised  any internally generated intangible assets. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfIntangibleAssetsAndGoodwillExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-480": {
   "value": "11, Intangible assets Notes Goodwill \u00a3\u2019000 Developed technology \u00a3\u2019000 Patents \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2021 \u2013 \u2013 5,636 5,636 At 31 December 2021 \u2013 \u2013 5,636 5,636 At 1 January 2022 \u2013 \u2013 5,636 5,636 Acquisitions through business combinations 35 610 102,869 \u2013 103,479 Retirements \u2013 \u2013 (3,825) (3,825) Effects of movements in exchange rates 51 8,536 \u2013 8,587 At 31 December 2022 661 111,405 1,811 113,877 Accumulated amortisation and impairment At 1 January 2021 \u2013 \u2013 5,563 5,563 Charge for the year \u2013 \u2013 21 21 At 31 December 2021 \u2013 \u2013 5,584 5,584 At 1 January 2022 \u2013 \u2013 5,584 5,584 Charge for the year \u2013 6,072 16 6,088 Retirements \u2013 \u2013 (3,797) (3,797) Effects of movements in exchange rates \u2013 116 \u2013 116 At 31 December 2022 \u2013 6,188 1,803 7,991 Net book amount at 31 December 2022 661 105,217 8 105,886 Net book amount at 31 December 2021 \u2013 \u2013 52 52 Intangible assets comprise Goodwill, Developed Technology and Patents for intellectual property rights. The Group has not capitalised  any internally generated intangible assets. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfGoodwillExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-465": {
   "value": "11, Intangible assets Notes Goodwill \u00a3\u2019000 Developed technology \u00a3\u2019000 Patents \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2021 \u2013 \u2013 5,636 5,636 At 31 December 2021 \u2013 \u2013 5,636 5,636 At 1 January 2022 \u2013 \u2013 5,636 5,636 Acquisitions through business combinations 35 610 102,869 \u2013 103,479 Retirements \u2013 \u2013 (3,825) (3,825) Effects of movements in exchange rates 51 8,536 \u2013 8,587 At 31 December 2022 661 111,405 1,811 113,877 Accumulated amortisation and impairment At 1 January 2021 \u2013 \u2013 5,563 5,563 Charge for the year \u2013 \u2013 21 21 At 31 December 2021 \u2013 \u2013 5,584 5,584 At 1 January 2022 \u2013 \u2013 5,584 5,584 Charge for the year \u2013 6,072 16 6,088 Retirements \u2013 \u2013 (3,797) (3,797) Effects of movements in exchange rates \u2013 116 \u2013 116 At 31 December 2022 \u2013 6,188 1,803 7,991 Net book amount at 31 December 2022 661 105,217 8 105,886 Net book amount at 31 December 2021 \u2013 \u2013 52 52 Intangible assets comprise Goodwill, Developed Technology and Patents for intellectual property rights. The Group has not capitalised  any internally generated intangible assets. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfIntangibleAssetsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-466": {
   "value": "12, Property, plant and equipment Group Freehold property \u00a3\u2019000 Leasehold improvements\u00b9 \u00a3\u2019000 Office equipment and computers  \u00a3\u2019000 Bioprocessing and Laboratory equipment \u00a3\u2019000 Right of use asset \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2022 25,409 28,145 10,663 29,505 18,411 112,133 Additions at cost 113 7,767 955 7,461 13,038 29,334 Reallocations 14 (417) (6) 409 \u2013 \u2013 Acquisitions through business combinations \u2013 22,747 788 10,436 24,974 58,945 Disposals (15,688) (45) (127) \u2013 (15,860) Change in estimate \u2013 \u2013 \u2013 \u2013 (1,349) (1,349) Effects of movements in exchange rates \u2013 1,986 65 912 2,072 5,035 At 31 December 2022 9,848 60,228 12,420 48,596 57,146 188,238 Accumulated depreciation At 1 January 2022 12,652 6,226 6,863 12,519 4,145 42,405 Charge for the year 2,052 5,167 2,204 5,916 4,932 20,271 Effects of movements in exchange rates \u2013 47 2 40 19 108 Disposals (8,210) \u2013 (27) (89) \u2013 (8,326) At 31 December 2022 6,494 11,440 9,042 18,386 9,096 54,458 Net book amount at 31 December 2022 3,354 48,788 3,378 30,210 48,050 133,780 Group Freehold property \u00a3\u2019000 Leasehold improvements \u00a3\u2019000 Office equipment and computers  \u00a3\u2019000 Bioprocessing and Laboratory equipment \u00a3\u2019000 Right of use asset \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2021 23,331 27,219 9,106 24,606 18,012 102,274 Additions at cost 2,078 939 1,557 4,886 21 9,481 Reclassi\ufb01cation \u2013 (13) \u2013 13 \u2013 \u2013 Disposals \u2013 \u2013 \u2013 \u2013 378 378 At 31 December 2021 25,409 28,145 10,663 29,505 18,411 112,133 Accumulated depreciation At 1 January 2021 10,444 3,519 4,610 9,177 2,220 29,970 Charge for the year 2,208 2,707 2,253 3,342 1,925 12,435 Reclassi\ufb01cation \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 At 31 December 2021 12,652 6,226 6,863 12,519 4,145 42,405 Net book amount at 31 December 2021 12,757 21,919 3,800 16,986 14,266 69,728 \u00b9    Included within Leasehold Improvements are Assets under Construction of \u00a35,541,000 (2021:\u00a3nil) representing ongoing construction works at Patriots Park, Boston, which will start being depreciated once completed and in use. Leasehold improvements are capital improvements to buildings which the Group leases. Bioprocessing and laboratory equipment is equipment purchased for the Group\u2019s laboratory and bioprocessing processes, and are generally movable from one facility to another. During the year a sale and leaseback transaction was completed on the Windrush facility and as a result assets with a net book value of \u00a37.5 million have been disposed of in the period and a Right of use Asset of \u00a35.8 million recognised at Group. Refer to note 33 for details of the lease. Company Right of use asset \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2022 \u2013 \u2013 Additions at cost 39,717 39,717 At 31 December 2022 39,717 39,717 Accumulated depreciation At 1 January 2022 \u2013 \u2013 Charge for the year 323 323 At 31 December 2022 323 323 Net book amount at 31 December 2022 39,394 39,394 The Windrush Court building was owned and then sold by Oxford Biomedica (UK) Ltd in October 2022, after which the building was immediately leased under a 15 year lease by Oxford Biomedica PLC on the same day. In the Company\u2019s individual accounts, the Company has accounted for the lease as a standalone lease with the resultant lease liability and matching right of use asset, whilst Oxford Biomedica (UK) Ltd has accounted for the transaction as a standalone sale of an asset. However, from a Group perspective the transaction has been accounted for as a sale and leaseback transaction as both companies form part of the same group and both the sale and leaseback was negotiated and entered into at the same time. The Company had no property, plant and equipment at 31 December 2021.",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfQuantitativeInformationAboutRightofuseAssetsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-430": {
   "value": "12, Property, plant and equipment Group Freehold property \u00a3\u2019000 Leasehold improvements\u00b9 \u00a3\u2019000 Office equipment and computers  \u00a3\u2019000 Bioprocessing and Laboratory equipment \u00a3\u2019000 Right of use asset \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2022 25,409 28,145 10,663 29,505 18,411 112,133 Additions at cost 113 7,767 955 7,461 13,038 29,334 Reallocations 14 (417) (6) 409 \u2013 \u2013 Acquisitions through business combinations \u2013 22,747 788 10,436 24,974 58,945 Disposals (15,688) (45) (127) \u2013 (15,860) Change in estimate \u2013 \u2013 \u2013 \u2013 (1,349) (1,349) Effects of movements in exchange rates \u2013 1,986 65 912 2,072 5,035 At 31 December 2022 9,848 60,228 12,420 48,596 57,146 188,238 Accumulated depreciation At 1 January 2022 12,652 6,226 6,863 12,519 4,145 42,405 Charge for the year 2,052 5,167 2,204 5,916 4,932 20,271 Effects of movements in exchange rates \u2013 47 2 40 19 108 Disposals (8,210) \u2013 (27) (89) \u2013 (8,326) At 31 December 2022 6,494 11,440 9,042 18,386 9,096 54,458 Net book amount at 31 December 2022 3,354 48,788 3,378 30,210 48,050 133,780 Group Freehold property \u00a3\u2019000 Leasehold improvements \u00a3\u2019000 Office equipment and computers  \u00a3\u2019000 Bioprocessing and Laboratory equipment \u00a3\u2019000 Right of use asset \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2021 23,331 27,219 9,106 24,606 18,012 102,274 Additions at cost 2,078 939 1,557 4,886 21 9,481 Reclassi\ufb01cation \u2013 (13) \u2013 13 \u2013 \u2013 Disposals \u2013 \u2013 \u2013 \u2013 378 378 At 31 December 2021 25,409 28,145 10,663 29,505 18,411 112,133 Accumulated depreciation At 1 January 2021 10,444 3,519 4,610 9,177 2,220 29,970 Charge for the year 2,208 2,707 2,253 3,342 1,925 12,435 Reclassi\ufb01cation \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 At 31 December 2021 12,652 6,226 6,863 12,519 4,145 42,405 Net book amount at 31 December 2021 12,757 21,919 3,800 16,986 14,266 69,728 \u00b9    Included within Leasehold Improvements are Assets under Construction of \u00a35,541,000 (2021:\u00a3nil) representing ongoing construction works at Patriots Park, Boston, which will start being depreciated once completed and in use. Leasehold improvements are capital improvements to buildings which the Group leases. Bioprocessing and laboratory equipment is equipment purchased for the Group\u2019s laboratory and bioprocessing processes, and are generally movable from one facility to another. During the year a sale and leaseback transaction was completed on the Windrush facility and as a result assets with a net book value of \u00a37.5 million have been disposed of in the period and a Right of use Asset of \u00a35.8 million recognised at Group. Refer to note 33 for details of the lease. Company Right of use asset \u00a3\u2019000 Total \u00a3\u2019000 Cost At 1 January 2022 \u2013 \u2013 Additions at cost 39,717 39,717 At 31 December 2022 39,717 39,717 Accumulated depreciation At 1 January 2022 \u2013 \u2013 Charge for the year 323 323 At 31 December 2022 323 323 Net book amount at 31 December 2022 39,394 39,394 The Windrush Court building was owned and then sold by Oxford Biomedica (UK) Ltd in October 2022, after which the building was immediately leased under a 15 year lease by Oxford Biomedica PLC on the same day. In the Company\u2019s individual accounts, the Company has accounted for the lease as a standalone lease with the resultant lease liability and matching right of use asset, whilst Oxford Biomedica (UK) Ltd has accounted for the transaction as a standalone sale of an asset. However, from a Group perspective the transaction has been accounted for as a sale and leaseback transaction as both companies form part of the same group and both the sale and leaseback was negotiated and entered into at the same time. The Company had no property, plant and equipment at 31 December 2021.",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfPropertyPlantAndEquipmentExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-431": {
   "value": "13, Assets at fair value through pro\ufb01t and loss Assets at fair value through pro\ufb01t and loss (FVTPL): Group 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January 74 239 Additions \u2013 \u2013 Sale of shares \u2013 \u2013 Change in fair value of FVTPL asset (51) (165) At 31 December 23 74 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-432": {
   "value": "14, Investments and loans in subsidiaries 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Shares in group undertakings At 1 January and 31 December 15,182 15,182 Loans to group undertakings At 1 January 273,253 262,002 Loan advanced in the year 153,602 11,251 At 31 December 426,855 273,253 Total investments in shares and loans to group undertakings 442,037 288,435 Accumulated impairment At 1 January and 31 December 126,065 126,065 Net book amount at 31 December 315,972 162,370 Capital contribution in respect of employee share schemes At 1 January 18,793 15,269 Additions in the year (note 27 and 28) 6,471 3,523 At 31 December 25,264 18,792 Total investments 341,237 18,792 The Company recognised a loss allowance for expected credit losses on \ufb01nancial assets. The expected credit losses are estimated by reference to an analysis of the subsidiary\u2019s current \ufb01nancial position and future repayment expectations. The loss allowance recognised on loans in subsidiaries at the end of the year was \u00a393.1 million (2021: \u00a393.1 million). In addition to the loss allowance recognised on loans in subsidiaries, an impairment loss is recognised under IAS 36 for shares in Group undertakings and for capital contribution in respectof employee share schemes of \u00a332.9 million (2021: \u00a332.9 million).The loan from Oxford Biomedica plc to Oxford Biomedica (UK) Limited is unsecured and interest free. The loan is legally due for repayment on demand though the expectation is that it will not be repaid within 12 months of the year end. Net investment in foreign operations: The company has designated a US$180 million intercompany loan to Oxford Biomedica (US) Inc as a monetary item that forms part of the Group\u2019s net investment in Oxford Biomedica Solutions with the foreign exchange differences recognised as a separate component in Other Comprehensive income until such time as the investment in Oxford Biomedica Solutions is disposed of. A translation gain of \u00a310.6 million was recognised in 2022 (2021: Nil). Interests in subsidiary undertakings Country of incorporation Description of shares held Proportion of nominal value of issued shares held by the Group  and Company Nature of business Oxford Biomedica (UK) Limited Great Britain 1p ordinary shares 100% Gene therapy research development and manufacturing Oxford Biomedica (Ireland) Limited Ireland 1p ordinary shares 100% Product release Oxxon Therapeutics Limited Great Britain 1p ordinary shares 100% Dormant Oxford Biomedica Solutions LLC United States N/A 80% Gene therapy research, development and manufacturing Oxford Biomedica (US) Inc. United States 1c ordinary shares 100% Business Development Invivusbio Limited Great Britain 1p ordinary shares 100% Dormant The registered office of the Company, its UK subsidiaries and Oxford Biomedica (US) Inc. is Windrush Court, Transport Way, Oxford, OX4 6LT. The registered office of Oxford Biomedica (Ireland) Ltd is Earlsfort Terrace, Dublin 2, DO2 T380, Ireland. The registered office of Oxford Biomedica Solutions LLC is 1 Patriots Park, Bedford, MA 01730, USA. In addition, the Group set up the Oxford Biomedica Employee Bene\ufb01t Trust (EBT) to hold market-purchased shares to settle the 2013 deferred bonus share awards made to Executive Directors and employees (note 27). All of the above subsidiaries have been consolidated in these \ufb01nancial statements. At each year end the Directors review the carrying value of the Company\u2019s investment in subsidiaries. Where there is a material and sustained shortfall in the market capitalisation, or a signi\ufb01cant and sustained change in the business resulting in a decrease in market capitalisation, the Directors consider this to be a trigger of an impairment review as set out in IAS 36, and the carrying value of the Company\u2019s investments in subsidiaries is adjusted. The Directors consider that reference to the market capitalisation of the Group is an appropriate external measure of the value of the Group for this purpose. Cumulative impairment of \u00a3126.0 million has been recognised up to 31 December 2022. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-467": {
   "value": "14, Investments and loans in subsidiaries 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Shares in group undertakings At 1 January and 31 December 15,182 15,182 Loans to group undertakings At 1 January 273,253 262,002 Loan advanced in the year 153,602 11,251 At 31 December 426,855 273,253 Total investments in shares and loans to group undertakings 442,037 288,435 Accumulated impairment At 1 January and 31 December 126,065 126,065 Net book amount at 31 December 315,972 162,370 Capital contribution in respect of employee share schemes At 1 January 18,793 15,269 Additions in the year (note 27 and 28) 6,471 3,523 At 31 December 25,264 18,792 Total investments 341,237 18,792 The Company recognised a loss allowance for expected credit losses on \ufb01nancial assets. The expected credit losses are estimated by reference to an analysis of the subsidiary\u2019s current \ufb01nancial position and future repayment expectations. The loss allowance recognised on loans in subsidiaries at the end of the year was \u00a393.1 million (2021: \u00a393.1 million). In addition to the loss allowance recognised on loans in subsidiaries, an impairment loss is recognised under IAS 36 for shares in Group undertakings and for capital contribution in respectof employee share schemes of \u00a332.9 million (2021: \u00a332.9 million).The loan from Oxford Biomedica plc to Oxford Biomedica (UK) Limited is unsecured and interest free. The loan is legally due for repayment on demand though the expectation is that it will not be repaid within 12 months of the year end. Net investment in foreign operations: The company has designated a US$180 million intercompany loan to Oxford Biomedica (US) Inc as a monetary item that forms part of the Group\u2019s net investment in Oxford Biomedica Solutions with the foreign exchange differences recognised as a separate component in Other Comprehensive income until such time as the investment in Oxford Biomedica Solutions is disposed of. A translation gain of \u00a310.6 million was recognised in 2022 (2021: Nil). Interests in subsidiary undertakings Country of incorporation Description of shares held Proportion of nominal value of issued shares held by the Group  and Company Nature of business Oxford Biomedica (UK) Limited Great Britain 1p ordinary shares 100% Gene therapy research development and manufacturing Oxford Biomedica (Ireland) Limited Ireland 1p ordinary shares 100% Product release Oxxon Therapeutics Limited Great Britain 1p ordinary shares 100% Dormant Oxford Biomedica Solutions LLC United States N/A 80% Gene therapy research, development and manufacturing Oxford Biomedica (US) Inc. United States 1c ordinary shares 100% Business Development Invivusbio Limited Great Britain 1p ordinary shares 100% Dormant The registered office of the Company, its UK subsidiaries and Oxford Biomedica (US) Inc. is Windrush Court, Transport Way, Oxford, OX4 6LT. The registered office of Oxford Biomedica (Ireland) Ltd is Earlsfort Terrace, Dublin 2, DO2 T380, Ireland. The registered office of Oxford Biomedica Solutions LLC is 1 Patriots Park, Bedford, MA 01730, USA. In addition, the Group set up the Oxford Biomedica Employee Bene\ufb01t Trust (EBT) to hold market-purchased shares to settle the 2013 deferred bonus share awards made to Executive Directors and employees (note 27). All of the above subsidiaries have been consolidated in these \ufb01nancial statements. At each year end the Directors review the carrying value of the Company\u2019s investment in subsidiaries. Where there is a material and sustained shortfall in the market capitalisation, or a signi\ufb01cant and sustained change in the business resulting in a decrease in market capitalisation, the Directors consider this to be a trigger of an impairment review as set out in IAS 36, and the carrying value of the Company\u2019s investments in subsidiaries is adjusted. The Directors consider that reference to the market capitalisation of the Group is an appropriate external measure of the value of the Group for this purpose. Cumulative impairment of \u00a3126.0 million has been recognised up to 31 December 2022. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-433": {
   "value": "15, Inventories Group 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Raw Materials 12,625 9,521 Total inventory 12,625 9,521 Inventories constitute raw materials held for commercial bioprocessing purposes, all of which the Group expects to recover within the next 12 months. During the year, the Group wrote down \u00a31,117,000 (2021: \u00a3766,000) of inventory which is not expected to be used in production or sold onwards. During the year, the Group wrote off \u00a311,717,000 of inventory as a result of cancelled orders from a client, which was recognised as part of cost of sales in the year. The Company holds no inventories. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfInventoriesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-434": {
   "value": "16, Trade and other receivables Group Company Current 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Trade receivables 34,109 22,398 \u2013 \u2013 Contract assets 10,897 13,547 \u2013 \u2013 Other receivables 4,832 365 \u2013 \u2013 Other tax receivable 7,757 5,227 \u2013 \u2013 Prepayments 3,976 3,210 \u2013 \u2013 Total trade and other receivables 61,571 44,747 \u2013 \u2013 Non-current trade and other receivables constitute other receivables of \u00a35,010,000 (2021: \u00a33,605,000) which are deposits held in escrow  as part of the Windrush Innovation Centre and Oxbox lease arrangements. The fair value of trade and other receivables are the current book values. The Group has performed an impairment assessment under  IFRS 9 and has concluded that the application of the expected credit loss model has had an immaterial impact on the level of impairment  of receivables. The carrying amounts of the Group\u2019s trade and other receivables are denominated in the following currencies: 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Sterling 50,395 44,527 US Dollar 16,186 3,825  66,581 48,352 The maximum exposure to credit risk at the reporting date is the fair value of each class of receivable above. The Group does not hold  any collateral as security. Trade receivables Included in the Group\u2019s trade receivable balance are debtors with a carrying amount of \u00a31,336,000 (2021: \u00a33,800,000) which were past  due at the reporting date and of which \u00a31,333,000 (2021: \u00a33,800,000) has been received after the reporting date. Ageing of past due but not impaired trade receivables: 2022 \u00a3\u2019000 2021 \u00a3\u2019000 0\u201330 days 171 3,266 30\u201360 days 3 389 60+ days 1,162 145 1,336 3,800 Contract assets Contract assets relates to the Group\u2019s rights to consideration for work completed but not invoiced at the reporting date for commercial  development work and bioprocessing batches. The contract assets are transferred to receivables when the rights become unconditional.  This usually occurs when the Group issues an invoice to the client. The balance of \u00a310.9 million (2021: \u00a313.5 million) mainly relates to commercial development milestones which have been accrued as the  speci\ufb01c conditions stipulated in the licence agreement have been met, commercial development work orders accrued on a percentage  complete basis which will be invoiced as the related work package completes, and bioprocessing batches accrued on a percentage of  completion basis which will be invoiced as the manufacturing of the batch is completed. Contract assets have decreased from \u00a313.5 million at the end of 2021 to \u00a310.9 million at the end of 2022 due to the timing of  bioprocessing and commercial development activities undertaken during the year leading to a lower level of consideration for work  completed but not yet billed. A portion of contract assets relates to \ufb01xed price process development work packages which are recognised on a percentage of  completion basis and as such requires estimation in terms of the assessment of the correct percentage of completion for that speci\ufb01c  work package. The value of the contract asset raised with regard to these work packages is \u00a38,179,000 (2021: \u00a38,022,000). If the assessed  percentage of completion was 1 percentage point higher or lower, revenue recognised in the period would have been \u00a382,000 higher or lower (2021: \u00a380,000). The Group performed an impairment assessment under IFRS 9 and has concluded that the application of the expected credit loss model  has had an immaterial impact on the level of impairment on contract assets. We have noted there has been no change in the time frame  for a right to consideration to become unconditional and the performance obligation to be satis\ufb01ed. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfTradeAndOtherReceivablesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-435": {
   "value": "17, Cash and cash equivalents Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Cash at bank and in hand 141,285 108,944 19,197 61,630 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfCashAndCashEquivalentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-436": {
   "value": "18, Trade and other payables Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Trade payables 13,604 5,260 \u2013 \u2013 Other taxation and social security 2,347 1,899 \u2013 \u2013 Accruals 20,628 11,899 143 152 Total trade and other payables 36,579 19,058 143 152 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfTradeAndOtherPayablesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-468": {
   "value": "19, Contract liabilities and deferred income Contract liabilities and deferred income arise when the Group has received payment for services in excess of the stage of completion of the services being provided. Contract liabilities and deferred income have increased from \u00a315.2 million at the end of 2021 to \u00a320.4 million at the end of 2022 due to funds received in advance for future licencing, bioprocessing and process development activities. Of the \u00a312.6 million balance included in the statement of \ufb01nancial position at the end of 2021, \u00a312.5 million has been recognised as revenue during the 2022 \ufb01nancial year. Contract liabilities consists primarily of deferred bioprocessing and process development revenues, which are expected to be released as the related performance obligations are satis\ufb01ed over the period as described below: At 31 December 2022 0\u20131 \u00a3\u2019000 1\u20133 \u00a3\u2019000 3\u20135 \u00a3\u2019000 5\u201310 \u00a3\u2019000 Total \u00a3\u2019000 Contract liabilities 18,370 32 32 12 18,446 Bioprocessing income 10,218 \u2013 \u2013 \u2013 10,218 Process development income 3,136 \u2013 \u2013 \u2013 3,136 Licence fees and Milestones 5,016 32 32 12 5,092 Deferred Income 894 1,069 \u2013 \u2013 1,963 Grant 894 1,069 \u2013 \u2013 1,963 At 31 December 2021 0\u20131 \u00a3\u2019000 1\u20133 \u00a3\u2019000 3\u20135 \u00a3\u2019000 5\u201310 \u00a3\u2019000 Total \u00a3\u2019000 Contract liabilities 12,502 48 44 \u2013 12,594 Bioprocessing income  9,755 \u2013 \u2013 \u2013 9,755 Process development income 2,325 \u2013 \u2013 \u2013 2,325 Licence fees and Milestones 422 48 44 \u2013 514 Deferred Income 894 1,760 \u2013 \u2013 2,654 Grant 894 1,760 \u2013 \u2013 2,654 Included within bioprocessing contract liabilities is revenue of \u00a32,592,000 million which has not been recognised during 2022 (2021: \u00a30.8 million) relating to the estimate of out of speci\ufb01cation batches (see note 2: \u2019Estimations\u2019 for additional information). Deferred income relates to grant funding received from the UK Government for capital equipment purchased as part of the Oxbox bioprocessing facility expansion. The income will be recognised over the period over which the purchased assets are depreciated. The Company had primarily no contract liabilities or deferred income in 2022 or 2021. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfDeferredIncomeExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-437": {
   "value": "19, Contract liabilities and deferred income Contract liabilities and deferred income arise when the Group has received payment for services in excess of the stage of completion of the services being provided. Contract liabilities and deferred income have increased from \u00a315.2 million at the end of 2021 to \u00a320.4 million at the end of 2022 due to funds received in advance for future licencing, bioprocessing and process development activities. Of the \u00a312.6 million balance included in the statement of \ufb01nancial position at the end of 2021, \u00a312.5 million has been recognised as revenue during the 2022 \ufb01nancial year. Contract liabilities consists primarily of deferred bioprocessing and process development revenues, which are expected to be released as the related performance obligations are satis\ufb01ed over the period as described below: At 31 December 2022 0\u20131 \u00a3\u2019000 1\u20133 \u00a3\u2019000 3\u20135 \u00a3\u2019000 5\u201310 \u00a3\u2019000 Total \u00a3\u2019000 Contract liabilities 18,370 32 32 12 18,446 Bioprocessing income 10,218 \u2013 \u2013 \u2013 10,218 Process development income 3,136 \u2013 \u2013 \u2013 3,136 Licence fees and Milestones 5,016 32 32 12 5,092 Deferred Income 894 1,069 \u2013 \u2013 1,963 Grant 894 1,069 \u2013 \u2013 1,963 At 31 December 2021 0\u20131 \u00a3\u2019000 1\u20133 \u00a3\u2019000 3\u20135 \u00a3\u2019000 5\u201310 \u00a3\u2019000 Total \u00a3\u2019000 Contract liabilities 12,502 48 44 \u2013 12,594 Bioprocessing income  9,755 \u2013 \u2013 \u2013 9,755 Process development income 2,325 \u2013 \u2013 \u2013 2,325 Licence fees and Milestones 422 48 44 \u2013 514 Deferred Income 894 1,760 \u2013 \u2013 2,654 Grant 894 1,760 \u2013 \u2013 2,654 Included within bioprocessing contract liabilities is revenue of \u00a32,592,000 million which has not been recognised during 2022 (2021: \u00a30.8 million) relating to the estimate of out of speci\ufb01cation batches (see note 2: \u2019Estimations\u2019 for additional information). Deferred income relates to grant funding received from the UK Government for capital equipment purchased as part of the Oxbox bioprocessing facility expansion. The income will be recognised over the period over which the purchased assets are depreciated. The Company had primarily no contract liabilities or deferred income in 2022 or 2021. ",
   "dimensions": {
    "concept": "ifrs-full:ExplanationOfSignificantChangesInContractAssetsAndContractLiabilitiesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-438": {
   "value": "20, Provisions Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January 6,244 5,839 \u2013 \u2013 Unwinding of discount 66 27 28 \u2013 Additional provision recognised 3,463 \u2013 3,207 \u2013 Change in estimate (1,349) 378 (477) \u2013 At 31 December 8,424 6,244 2,758 \u2013 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Current \u2013 \u2013 \u2013 \u2013 Non-current 8,424 6,244 2,758 \u2013 Total provisions 8,424 6,244 2,758 \u2013 Provisions are exclusively in respect of dilapidations. The new provisions during the year relate to new lease liabilities at the Wallingford  Warehouse, and as a result of the sale and leaseback by the Company of the Windrush Court facility the provisions are based on the  anticipated costs of restoring the leaseholds at the end of the lease terms, both of which are 2037. The existing dilapidations provisions  relate to anticipated costs of restoring the leasehold Yarnton, Oxbox, Windrush Innovation Centre and Corporate Office properties in  Oxford, UK to their original condition at the end of the lease terms in 2024, 2033, 2028 and 2030 respectively. The future anticipated costs of restoring the properties is calculated by in\ufb02ating the current expected restoration costs using the 3 year  historic UK Consumer Price In\ufb02ation rate, up to the end of the lease term. The discount rate utilised for the purpose of determining the  present value of the provision is 5.41% based on the risk free rate adjusted for in\ufb02ation. The present value of the future anticipated costs  of restoration is calculated by discounting the future expected value using the nominal rate. The unwinding of this discount over time is  included within \ufb01nance costs. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfProvisionsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-439": {
   "value": "21, Loans On 10 March 2022, the Group drew down an US$85 million loan facility with Oaktree to \ufb01nance the acquisition of Oxford Biomedica  Solutions under a 1 year facility agreement maturing in 2023. Over the course of the term loan interest was payable quarterly with a nominal interest rate on the loan of 8.5%.  On 7 October 2022, the loan facility was re\ufb01nanced with Oaktree. Under the terms of such re\ufb01nancing, the Company has partially repaid  the outstanding amounts under the Short-Term Loan Facility and amended the facility into a new senior secured four year term loan  facility provided by Oaktree in a principal amount of US$50 million. The Term Loan will mature four years after the date of completion  and will not amortise, with the full aggregate principal and outstanding amount being repayable on the \ufb01nal maturity date. The Term Loan carries a variable interest rate, which is capped at 10.25% per annum and payable quarterly in cash, with up to 50% of interest for the  \ufb01rst twelve months payable in kind as additional loan principal, at the option of the Company. The interest rate is subject to downward  adjustment following the satisfaction of certain commercial conditions. The Company also has secured the option, subject to the same commercial conditions as the amended facility and available for a three- year period, to draw down a further US$25 million from Oaktree to fund certain permitted acquisitions. If the option were to be exercised,  it would be assessed against meeting the substantial modi\ufb01cation requirements under IFRS 9. The terms include \ufb01nancial covenants including holding a minimum of US$20 million cash at all times, restrictions on the level  of indebtedness the Group may enter into or distributions made by the Group. The Oaktree facility was secured by a pledge over  substantially all of the Group\u2019s assets. Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January \u2013 \u2013  \u2013 \u2013 New Loan 64,866 \u2013 64,866 \u2013 Interest accrued 5,564 \u2013 5,564 \u2013 Interest paid (4,554) \u2013 (4,554) \u2013 Foreign exchange movement 7,964 \u2013 7,964 \u2013 Amortised fees 588 \u2013 588 \u2013 Loan repayment (31,424) \u2013 (31,424) \u2013 Arrangement fees (3,224) \u2013 (3,224) \u2013 At 31 December 39,780 \u2013 39,780 \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfLoansAndAdvancesToBanksExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-440": {
   "value": "22, Put option liability 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January \u2013 \u2013 Recognised at fair value 38,996 \u2013 Revaluation (814) \u2013 At 31 December 38,182 \u2013 On 10th March 2022, the Group recognised a put option liability to acquire the remaining 20% of Oxford Biomedica Solutions that it doesn\u2019t already own from Homology Medicines. The fair value of the option at the date of acquisition was assessed to be \u00a339.0 million. At 31st December 2022 the fair value of the Put option liability was \u00a338.2 million (Dec 2021: \u00a3nil). The lower liability valuation was due to increases in borrowing rates over the period leading to a higher discount rate applied and a resultant lower put option liability. ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DisclosureOfPutOptionLiability",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-441": {
   "value": "23, Financial instruments The Group and Company\u2019s \ufb01nancial instruments comprise cash and cash equivalents, trade and other receivables, assets at fair value through pro\ufb01t and loss, and trade and other payables. Additional disclosures are set out in the Corporate Governance Report and in note 3 relating to risk management. The Group had the following \ufb01nancial instruments at 31 December each year: Financial assets\u2009/\u2009\ufb01nancial liabilities at fair value through pro\ufb01t and loss Cash and receivables Amortised costs, loans  and other liabilities 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Cash and cash equivalents (note 17) \u2013 \u2013 141,285 108,944 \u2013 \u2013 Trade receivables and other receivables (note 16) \u2013 \u2013 62,605 45,142 \u2013 \u2013 Assets at fair value through pro\ufb01t and loss (note 13) 23 74 \u2013 \u2013 \u2013 \u2013 Trade and other payables excluding tax (note 18) \u2013 \u2013 \u2013 \u2013 34,232 17,160 Loan (note 21) \u2013 \u2013 \u2013 \u2013 39,780 \u2013 Put option liability (note 22)\u2009\u00b9 \u2013 \u2013 \u2013 \u2013 38,182 \u2013 23 74 203,890 154,086 112,194 17,160 1  Although the put option is included within the amortised cost table, it is not measured at amortised cost but at the fair value of the expected consideration payable. The Company had the following \ufb01nancial instruments at 31 December each year: Cash and receivables Amortised costs, loans  and other liabilities 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Cash and cash equivalents (note 17) 19,197 61,630 \u2013 \u2013 Trade and other payables excluding tax (note 18) \u2013 \u2013 143 152 Loan (note 21) \u2013 \u2013 39,780 \u2013  19,197 61,630 39,923 152 Floating rate instant access deposits earned interest at prevailing bank rates. 2022 Weighted average rate 2021 Weighted average rate Sterling 1.67% 0.02% US Dollar 1.26% 0.00% Assessment of \ufb01nancial assets by credit risk rating: Cash and cash equivalents are held with reputable banks with a low assessed risk of default. All trade receivables are assessed as having a low credit risk rating as the debt is owed by blue chip pharmaceutical groups in the top 10  in the world by market capitalisation, and by biotechnology companies with sufficient cash reserves to satisfy their obligations. There  has been no change in the determined risk during 2022, therefore no reconciliation between the 2021 and 2022 closing debtor balance  assessed by risk of default has been provided. The opening and closing position was low (2021: low). Other receivables are rent deposits held in separately administered bank accounts with covenants limiting their use and are as such  assessed as having a low risk of default. The Group considers a \ufb01nancial asset to be in default when:  \u2014 The debtor is unlikely to pay its credit obligation to the Group in full, without recourse by the Group to actions such as realising  security (if any is held); or   \u2014 the \ufb01nancial asset is more than 90 days past its contracted due date. Fair value The Directors consider that the fair values of the Group\u2019s \ufb01nancial instruments do not differ signi\ufb01cantly from their book values. The carrying amounts of the Group\u2019s cash and cash equivalents are denominated in the following currencies: 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Sterling 117,247 96,477 Euro 623 524 US Dollar 23,415 11,943 141,285 108,944 Financial assets classi\ufb01ed as level 1 in hierarchy The investment asset represented by ordinary shares in Orchard Therapeutics is classi\ufb01ed as at fair value through pro\ufb01t and loss. Please refer to note 13 for further information. Financial liabilities classi\ufb01ed as level 3 in hierarchy The Put option liability is classi\ufb01ed as at fair value as a liability. Please refer to note 22 for further information. Measurement of fair values Valuation techniques and signi\ufb01cant unobservable inputs: The following table shows the valuation techniques used in measuring level 3 fair values, as well as the signi\ufb01cant unobservable inputs used: Type Valuation technique Signi\ufb01cant unobservable inputs Interrelationship between unobservable inputs  and fair value measurement: Put option liability Monte Carlo simulation Revenues of Oxford Biomedica  Solutions \u2014  The revenues of Oxford Biomedica Solutions  are based on the management approved  forecast up until the end of the option period.  Should the forecast change or the actual  results vary this may impact the value of the  put option liability. Discount rate \u2014  The discount rate may be impacted by  economic and market factors, as well as  changes to the risk free rate of return which  impacts debt borrowing rates. Should the  discount rate calculated by management be  adjusted, this may impact the value of the  put option. Management has calculated the  discount rate based on the risk free rate, the expected return from similar companies  and the Group\u2019s cost of debt. Sensitivity analysis For the fair values of the put option liability, reasonably possible changes at the reporting date to one of the signi\ufb01cant unobservable inputs, holding other inputs constant, would have the following effects: Fair value Put option liability  31 December 2022      Increase Decrease Effect in thousands of pounds: Revenues of Oxford Biomedica Solutions: 10% higher or lower 2.1 (2.4) Discount rate 2% lower or higher 1.4 (1.4 ) Reconciliation of movements of liabilities to cash \ufb02ows arising from \ufb01nancing activities Liabilities Equity Total Group Lease liabilities \u00a3\u2019000 Loan \u00a3\u2019000 Share capital \u00a3\u2019000 Share Premium \u00a3\u2019000 Total \u00a3\u2019000 Balance at 1 January 2021 13,845 \u2013 41,161 258,017 313,023 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 236 1,439 1,675 Issue of shares excluding options \u2013 \u2013 1,691 48,309 50,000 Payments for the principal portion of lease liabilities (4,520) \u2013 \u2013 \u2013 (4,520) Payments for the interest portion of lease liabilities (873) \u2013 \u2013 \u2013 (873) Total changes from \ufb01nancing cash \ufb02ows (5,393) \u2013 1,927 49,748 46,282 Other changes: Additions 16 \u2013 \u2013 \u2013 16 Interest 873 \u2013 \u2013 \u2013 873 Balance at 31 December 2021 9,341 \u2013 43,088 307,765 360,194 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 106 78 184 Issue of shares excluding options \u2013 \u2013 4,938 75,062 80,000 Cost of share issues \u2013 \u2013 \u2013 (2,952) (2,952) Loans received \u2013 64,866 \u2013 \u2013 64,866 Loans repaid \u2013 (31,424) \u2013 \u2013 (31,424) Arrangement fees \u2013 (3,224) \u2013 \u2013 (3,224) Interest paid \u2013 (4,554) \u2013 \u2013 (4,554) Payments for the principal portion of lease liabilities (1,120) \u2013 \u2013 \u2013 (1,120) Payments for the interest portion of lease liabilities (3,124) \u2013 \u2013 \u2013 (3,124) Total changes from \ufb01nancing cash \ufb02ows (4,244) 25,664 5,044 72,188 98,652 Other changes:        Acquisitions 24,974 \u2013 \u2013 \u2013 24,974 Additions 39,193 \u2013 \u2013 \u2013 39,193 Interest 3,124 5,564 \u2013 \u2013 8,688 Fee amortisation \u2013 588 \u2013 \u2013 588 Foreign exchange 2,113 7,964 \u2013 \u2013 10,077 Closing balance at 31 December 2022 74,501 39,780 48,132 379,953 542,366 Liabilities Equity Total Company Lease liabilities \u00a3\u2019000 Loan \u00a3\u2019000 Share capital \u00a3\u2019000 Share Premium \u00a3\u2019000 Total \u00a3\u2019000 Balance at 1 January 2021 \u2013 \u2013 41,161 258,017 299,178 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 236 1,439 1,675 Issue of shares excluding options \u2013 \u2013 1,691 48,309 50,000 Total changes from \ufb01nancing cash \ufb02ows \u2013 \u2013 1,927 49,748 51,675 Balance at 31 December 2021 \u2013 \u2013 43,088 307,765 350,853 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 106 78 184 Issue of shares excluding options \u2013 \u2013 4,938 75,062 80,000 Cost of share issues \u2013 \u2013 \u2013 (2,952) (2,952) Loans received \u2013 64,866 \u2013 \u2013 64,866 Loans repaid \u2013 (31,424) \u2013 \u2013 (31,424) Interest paid \u2013 (4,554) \u2013 \u2013 (4,554) Arrangement fees \u2013 (3,224) \u2013 \u2013 (3,224) Payments for the principal portion of lease liabilities 55 \u2013 \u2013 \u2013 55 Payments for the interest portion of lease liabilities (477) \u2013 \u2013 \u2013 (477) Total changes from \ufb01nancing cash \ufb02ows (422) 25,664 5,044 72,188 102,474 Other changes:        Additions 35,567 \u2013 \u2013 \u2013 35,567 Interest 477 5,564 \u2013 \u2013 6,041 Fee amortisation \u2013 588 \u2013 \u2013 588 Foreign exchange \u2013 7,964 \u2013 \u2013 7,964 Closing balance at 31 December 2022 35,622 39,780 48,132 379,953 503,487 Exposure to Liquidity Risk Contractual Cash \ufb02ows Group  At 31 December 2022 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities 74,501 119,496 \u2013 9,179 18,681 24,353 67,283 Loans 39,780 59,082 \u2013 4,294 4,306 50,482 \u2013 Contractual Cash \ufb02ows Group  At 31 December 2021 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities 9,341 13,456 \u2013 1,590 3,033 2,850 5,983 Loans \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 Contractual Cash \ufb02ows Company  At 31 December 2022 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities 35,622 63,226 \u2013 3,500 7,000 6,300 46,426 Loans 39,780 59,082 \u2013 4,294 4,306 50,482 \u2013 Contractual Cash \ufb02ows Company  At 31 December 2021 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 Loans \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFinancialInstrumentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-469": {
   "value": "Fair value The Directors consider that the fair values of the Group\u2019s \ufb01nancial instruments do not differ signi\ufb01cantly from their book values. The carrying amounts of the Group\u2019s cash and cash equivalents are denominated in the following currencies: 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Sterling 117,247 96,477 Euro 623 524 US Dollar 23,415 11,943 141,285 108,944 Financial assets classi\ufb01ed as level 1 in hierarchy The investment asset represented by ordinary shares in Orchard Therapeutics is classi\ufb01ed as at fair value through pro\ufb01t and loss. Please refer to note 13 for further information. Financial liabilities classi\ufb01ed as level 3 in hierarchy The Put option liability is classi\ufb01ed as at fair value as a liability. Please refer to note 22 for further information. Measurement of fair values Valuation techniques and signi\ufb01cant unobservable inputs: The following table shows the valuation techniques used in measuring level 3 fair values, as well as the signi\ufb01cant unobservable inputs used: Type Valuation technique Signi\ufb01cant unobservable inputs Interrelationship between unobservable inputs  and fair value measurement: Put option liability Monte Carlo simulation Revenues of Oxford Biomedica  Solutions \u2014  The revenues of Oxford Biomedica Solutions  are based on the management approved  forecast up until the end of the option period.  Should the forecast change or the actual  results vary this may impact the value of the  put option liability. Discount rate \u2014  The discount rate may be impacted by  economic and market factors, as well as  changes to the risk free rate of return which  impacts debt borrowing rates. Should the  discount rate calculated by management be  adjusted, this may impact the value of the  put option. Management has calculated the  discount rate based on the risk free rate, the expected return from similar companies  and the Group\u2019s cost of debt. Sensitivity analysis For the fair values of the put option liability, reasonably possible changes at the reporting date to one of the signi\ufb01cant unobservable inputs, holding other inputs constant, would have the following effects: Fair value Put option liability  31 December 2022      Increase Decrease Effect in thousands of pounds: Revenues of Oxford Biomedica Solutions: 10% higher or lower 2.1 (2.4) Discount rate 2% lower or higher 1.4 (1.4 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfFairValueOfFinancialInstrumentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-470": {
   "value": "Reconciliation of movements of liabilities to cash \ufb02ows arising from \ufb01nancing activities Liabilities Equity Total Group Lease liabilities \u00a3\u2019000 Loan \u00a3\u2019000 Share capital \u00a3\u2019000 Share Premium \u00a3\u2019000 Total \u00a3\u2019000 Balance at 1 January 2021 13,845 \u2013 41,161 258,017 313,023 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 236 1,439 1,675 Issue of shares excluding options \u2013 \u2013 1,691 48,309 50,000 Payments for the principal portion of lease liabilities (4,520) \u2013 \u2013 \u2013 (4,520) Payments for the interest portion of lease liabilities (873) \u2013 \u2013 \u2013 (873) Total changes from \ufb01nancing cash \ufb02ows (5,393) \u2013 1,927 49,748 46,282 Other changes: Additions 16 \u2013 \u2013 \u2013 16 Interest 873 \u2013 \u2013 \u2013 873 Balance at 31 December 2021 9,341 \u2013 43,088 307,765 360,194 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 106 78 184 Issue of shares excluding options \u2013 \u2013 4,938 75,062 80,000 Cost of share issues \u2013 \u2013 \u2013 (2,952) (2,952) Loans received \u2013 64,866 \u2013 \u2013 64,866 Loans repaid \u2013 (31,424) \u2013 \u2013 (31,424) Arrangement fees \u2013 (3,224) \u2013 \u2013 (3,224) Interest paid \u2013 (4,554) \u2013 \u2013 (4,554) Payments for the principal portion of lease liabilities (1,120) \u2013 \u2013 \u2013 (1,120) Payments for the interest portion of lease liabilities (3,124) \u2013 \u2013 \u2013 (3,124) Total changes from \ufb01nancing cash \ufb02ows (4,244) 25,664 5,044 72,188 98,652 Other changes:        Acquisitions 24,974 \u2013 \u2013 \u2013 24,974 Additions 39,193 \u2013 \u2013 \u2013 39,193 Interest 3,124 5,564 \u2013 \u2013 8,688 Fee amortisation \u2013 588 \u2013 \u2013 588 Foreign exchange 2,113 7,964 \u2013 \u2013 10,077 Closing balance at 31 December 2022 74,501 39,780 48,132 379,953 542,366 Liabilities Equity Total Company Lease liabilities \u00a3\u2019000 Loan \u00a3\u2019000 Share capital \u00a3\u2019000 Share Premium \u00a3\u2019000 Total \u00a3\u2019000 Balance at 1 January 2021 \u2013 \u2013 41,161 258,017 299,178 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 236 1,439 1,675 Issue of shares excluding options \u2013 \u2013 1,691 48,309 50,000 Total changes from \ufb01nancing cash \ufb02ows \u2013 \u2013 1,927 49,748 51,675 Balance at 31 December 2021 \u2013 \u2013 43,088 307,765 350,853 Changes from \ufb01nancing cash \ufb02ows Share options \u2013 Proceeds from shares issued \u2013 \u2013 106 78 184 Issue of shares excluding options \u2013 \u2013 4,938 75,062 80,000 Cost of share issues \u2013 \u2013 \u2013 (2,952) (2,952) Loans received \u2013 64,866 \u2013 \u2013 64,866 Loans repaid \u2013 (31,424) \u2013 \u2013 (31,424) Interest paid \u2013 (4,554) \u2013 \u2013 (4,554) Arrangement fees \u2013 (3,224) \u2013 \u2013 (3,224) Payments for the principal portion of lease liabilities 55 \u2013 \u2013 \u2013 55 Payments for the interest portion of lease liabilities (477) \u2013 \u2013 \u2013 (477) Total changes from \ufb01nancing cash \ufb02ows (422) 25,664 5,044 72,188 102,474 Other changes:        Additions 35,567 \u2013 \u2013 \u2013 35,567 Interest 477 5,564 \u2013 \u2013 6,041 Fee amortisation \u2013 588 \u2013 \u2013 588 Foreign exchange \u2013 7,964 \u2013 \u2013 7,964 Closing balance at 31 December 2022 35,622 39,780 48,132 379,953 503,487 31, Cash \ufb02ows from operating activities Reconciliation of loss before tax to net cash used in operations: Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Continuing operations (Loss)/pro\ufb01t before taxation (45,976) 19,880 (4,804) (2,366) Adjustment for: Depreciation 20,271 12,435 323 \u2013 Amortisation of intangible assets 6,088 21 \u2013 \u2013 Loss on disposal of property, plant and equipment 28 \u2013 \u2013 \u2013 (Gain) on sale and leaseback (21,389) \u2013 \u2013 \u2013 Loss on disposal of intangible 27 \u2013 \u2013 \u2013 Amortisation of loan fees 588 \u2013 588 \u2013 Finance costs 15,756 888 14,033 \u2013 Charge in relation to employee share schemes 6,471 3,981 \u2013 \u2013 Non-cash loss 51 165 \u2013 \u2013 Changes in working capital: (Increase)/decrease in trade and other receivables (17,876) 6,891 \u2013 \u2013 Increase/(decrease) in trade and other payables 16,959 (657) 6 17 Decrease in deferred income (691) (867) \u2013 \u2013 Increase/(decrease)/ in contract liabilities 5,852 (15,667) \u2013 \u2013 Decrease/(increase) in inventory 688 (2,609) \u2013 \u2013 Net cash (used in)/generated from operations (13,173) 24,461 10,146 (2,349) ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfCashFlowStatementExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-471": {
   "value": "Exposure to Liquidity Risk Contractual Cash \ufb02ows Group  At 31 December 2022 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities 74,501 119,496 \u2013 9,179 18,681 24,353 67,283 Loans 39,780 59,082 \u2013 4,294 4,306 50,482 \u2013 Contractual Cash \ufb02ows Group  At 31 December 2021 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities 9,341 13,456 \u2013 1,590 3,033 2,850 5,983 Loans \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 Contractual Cash \ufb02ows Company  At 31 December 2022 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities 35,622 63,226 \u2013 3,500 7,000 6,300 46,426 Loans 39,780 59,082 \u2013 4,294 4,306 50,482 \u2013 Contractual Cash \ufb02ows Company  At 31 December 2021 Carrying Amount \u00a3\u2019000 Total  \u00a3\u2019000 2 months or less  \u00a3\u2019000 2\u201312 months \u00a3\u2019000 1\u20132 years \u00a3\u2019000 2\u20135 years \u00a3\u2019000 >5 years \u00a3\u2019000 Lease Liabilities \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 Loans \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfLiquidityRiskExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-442": {
   "value": "24, Deferred taxation U.K. deferred tax The Group has recognised UK deferred tax assets and liabilities at 31 December 2022 and 31 December 2021. In light of the Group\u2019s history of losses, recovery of the whole deferred tax asset is not sufficiently certain, and therefore a deferred tax asset has been recognised only to the extent that there is a deferred tax liability. Finance Act 2020 enacted provisions to increase the UK Corporation tax rate to 19% from 1 April 2021. Finance Act 2021 which was Substantively Enacted on 24 May 2022 included provisions to increase the rate further to 25% effective from 1 April 2023 and this rate has been applied when calculating the UK deferred tax at the year end. U.S. deferred tax The Group have recognised US deferred tax assets and liabilities at 31 December 2022 (31 December 2021: Nil). The remaining deferred tax assets have not been recognised as there is uncertainty regarding when suitable future pro\ufb01ts against which to offset the tax losses will arise. U.S. deferred tax assets and liabilities are calculated at a blended rate of approximately 28%. Group \u2013 recognised Deferred tax (assets)/liabilities \u2013 recognised Trading temporary differences \u00a3\u2019000 Fixed assets \u00a3\u2019000 Tax losses \u00a3\u2019000 Intangible assets \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 \u2013 3,051 (3,051) \u2013 \u2013 Arising on acquisition \u2013 \u2013 \u2013 7,397 7,397 Foreign exchange \u2013 \u2013 \u2013 508 508 Income statement credit (1,256) 306 (439) (403) (1,792) At 31 December 2022 (1,256) 3,357 (3,490) 7,502 6,113 At 1 January 2021 \u2013 \u2013 \u2013 \u2013 \u2013 Origination and reversal of temporary differences \u2013 3,051 (3,051) \u2013 \u2013 At 31 December 2021 \u2013 3,051 (3,051) \u2013 \u2013 Group \u2013 not recognised Deferred tax (assets)/liabilities \u2013  not recognised Intangibles \u00a3\u2019000 Loan  relationships \u00a3\u2019000 Provisions \u00a3\u2019000 Tax losses \u00a3\u2019000 Share options \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 \u2013 (1,668) (298) (21,760) (6,176) (29,902) Origination and reversal of  temporary differences (4,819) 1,668 50 3,511 3,871 4,281 At 31 December 2022 (4,819) \u2013 (248) (18,249) (2,305) (25,621) At 1 January 2021 \u2013 (1,267) (206)  (17,443) (3,239)  (22,155) Origination and reversal  of temporary differences \u2013 (401) (92)  (4,317) (2,937)  (7,747) At 31 December 2021 \u2013 (1,668) (298)  (21,760) (6,176)  (29,902) Oxford Biomedica PLC has unrecognised deferred tax assets of \u00a335,000 relating to non temporary trading differences. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfDeferredTaxesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-443": {
   "value": "25, Ordinary shares Group and Company Issued and fully paid 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Ordinary shares of 50p each At 1 January \u2013 86,175,055 (2021: 82,320,585) shares 43,088 41,161 Allotted for cash in placing and subscription \u2013 9,876,544 (2021: 3,382,950) shares 4,938 1,691 Allotted on exercise of share options \u2013 212,646 (2021: 471,520) 106 236 At 31 December \u2013 96,263,165 (2021: 86,175,055) shares 48,132 43,088 The share capital of the Company consists only of fully paid ordinary shares with a nominal (par) value of \u00a30.50 per share. There are no restrictions on the ability of shareholders to receive dividends, nor on the repayment of capital. All ordinary shares are equally eligible  to receive dividends and the repayment of capital in accordance with the Company\u2019s Articles of Association and represent one vote at shareholders\u2019 meetings of the Company. As part of the \ufb01nancing arrangements for the Oxford Biomedica Solutions acquisition, the Group raised gross proceeds of \u00a380 million through  a placing of 9,876,544 shares at \u00a38.10 per share. The placing was done in 2 tranches with 5,018,134 shares placed on 28 January 2022, and a  further 4,858,410 shares were placed on 10 March 2022. 26, Share premium account Group and Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January 307,765 258,017 Premium on shares issued for cash in placing and subscription 75,062 48,309 Premium on exercise of share options 78 1,439 Costs associated with the issue of shares (2,952) \u2013 At 31 December 379,953 307,765 29, Accumulated losses Group Company Notes 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January (165,806) (188,723) (128,584) (126,143) (Loss)/pro\ufb01t for the year (39,157) 19,011 (4,804) (2,366) Share based payments 5,922 3,523 \u2013 \u2013 Acquisition of NCI without a change in control 37 400 \u2013 \u2013 \u2013 Deferred tax on share options 125 458 \u2013 \u2013 Exercise of nil cost option (29) (75) (15) (75) At 31 December (198,545) (165,806) (133,403) (128,584) \u00b9   The credit to accumulated losses is made up out of the charge for the year relating to employee share-based payment plans of \u00a35,442,000 (2021: \u00a32,486,000) (note 28), \u00a31,029,000 (2021: \u00a31,037,000) related to the vesting of deferred share awards made to executive directors and senior managers less \u00a3549,000 of share based payment charge allocated to Non controlling interests. Neither the Company nor its subsidiary undertakings had reserves available for distribution at 31 December 2022 or 31 December 2021. 30, Other reserves Group Translation Reserve  \u00a3\u2019000 Other equity \u00a3\u2019000 Merger reserve \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 \u2013 \u2013 2,291 2,291 Put option recognition \u2013 (38,996) \u2013 (38,996) Put option revaluation \u2013 3,993 \u2013 3,993 Foreign currency translation differences 7,825 \u2013 \u2013 7,825 At 31 December 2022 7,825 (35,003) 2,291  (24,887) Group Merger reserve \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 2,291 2,291 At 31 December 2022 2,291 2,291 At 1 January 2021 2,291 2,291 At 31 December 2021 2,291 2,291 Company Merger reserve \u00a3\u2019000 Share Scheme Reserve \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 1,580 18,792 20,372 Credit in relation to employee share schemes \u2013 6,471 6,471 At 31 December 2022 1,580 25,263 26,843 At 1 January 2021 1,580 15,269 16,849 Credit in relation to employee share schemes \u2013 3,523 3,523 At 31 December 2021 1,580 18,792 20,372 Merger reserve The Group merger reserve at 31 December 2022 and 2021 comprised \u00a3711,000 arising from the consolidation of Oxford Biomedica (UK) Ltd using the merger method of accounting in 1996, and \u00a31,580,000 from the application of merger relief to the purchase of Oxxon Therapeutics Limited in 2007. Share scheme reserve Options over the Company\u2019s shares have been awarded to employees of Oxford Biomedica (UK) Ltd., Oxford Biomedica Solutions and Oxford Biomedica (US) Inc. In accordance with IFRS 2 \u2019Share-based Payment\u2019 the expense in respect of these awards is recognised in the subsidiaries\u2019 \ufb01nancial statements (see note 27). In accordance with IFRS 2, the Company has treated the awards as a capital contribution to the subsidiaries, resulting in an increase in the cost of investment of \u00a36,471,000 (2021: \u00a33,523,000) (see note 14) and  a corresponding credit to reserves. 36, Non-controlling interest The proportion of the identi\ufb01able net assets of the Non-controlling interest in Oxford Biomedica Solutions on acquisition was determined to be \u00a334,642,000. Following a review of the accounting for the acquisition of Oxford Biomedica Solutions it was identi\ufb01ed that the fair value initially attributed to the non-controlling interest was not appropriate. As a result, the group has elected to change its accounting policy for the initial recognition of non-controlling interest from fair value at date of acquisition to the holders' proportionate interest in the recognised amount of the identi\ufb01able net assets of the acquiree. This valuation method better re\ufb02ects the value of the business attributable to the non-controlling shareholders. This has resulted in a reduction in the initial value of non-controlling interest from \u00a348.4 million to \u00a334.6 million, a corresponding reduction of 'Goodwill' recognised on acquisition from \u00a314.4 million to \u00a30.6 million and a reduction in the 'Acquisition of NCI without a change in control' of \u00a311.3 million to \u00a30.4 million. The overall impact of this to net assets is \u00a313.8 million with no impact to pro\ufb01t or loss recognised in the period.The following table summarises the information relating to the Group\u2019s subsidiary that has material NCI: 2022 \u00a3\u2019000 NCI percentage 20% Non current assets 171,419 Current assets 29,732 Non-current liabilities (7,473) Current liabilities (35,979) Net assets\u00b9 157,699 Net assets attributable to NCI 31,539 \u00b9 Net assets include the impact of share based payments. Revenue 23,722 Pro\ufb01t (30,011) OCI 13,756 Total comprehensive income (16,255) Pro\ufb01t allocated to NCI (6,002) OCI allocated to NCI 2,750 Cash \ufb02ows from operating activities (9,732) Cash \ufb02ows from investment activities 30,867 Cash \ufb02ow from \ufb01nancing activities (dividends to NCI: nil) (2,293) Net increase in cash and cash equivalents 18,842 There was no Non-controlling interest in 2021. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-472": {
   "value": "25, Ordinary shares Group and Company Issued and fully paid 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Ordinary shares of 50p each At 1 January \u2013 86,175,055 (2021: 82,320,585) shares 43,088 41,161 Allotted for cash in placing and subscription \u2013 9,876,544 (2021: 3,382,950) shares 4,938 1,691 Allotted on exercise of share options \u2013 212,646 (2021: 471,520) 106 236 At 31 December \u2013 96,263,165 (2021: 86,175,055) shares 48,132 43,088 The share capital of the Company consists only of fully paid ordinary shares with a nominal (par) value of \u00a30.50 per share. There are no restrictions on the ability of shareholders to receive dividends, nor on the repayment of capital. All ordinary shares are equally eligible  to receive dividends and the repayment of capital in accordance with the Company\u2019s Articles of Association and represent one vote at shareholders\u2019 meetings of the Company. As part of the \ufb01nancing arrangements for the Oxford Biomedica Solutions acquisition, the Group raised gross proceeds of \u00a380 million through  a placing of 9,876,544 shares at \u00a38.10 per share. The placing was done in 2 tranches with 5,018,134 shares placed on 28 January 2022, and a  further 4,858,410 shares were placed on 10 March 2022. 26, Share premium account Group and Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January 307,765 258,017 Premium on shares issued for cash in placing and subscription 75,062 48,309 Premium on exercise of share options 78 1,439 Costs associated with the issue of shares (2,952) \u2013 At 31 December 379,953 307,765 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfIssuedCapitalExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-444": {
   "value": "27, Options over shares of Oxford Biomedica plc The Company has outstanding share options that were issued under the following schemes: \u2014 The 2007 Share Option Scheme (approved February 2007) \u2014 The 2015 Executive Share Option Scheme (approved May 2015) \u2014 The 2007 Long Term Incentive Plan (LTIP) (approved February 2007) \u2014 The 2015 Long Term Incentive Plan (LTIP) (approved May 2015) \u2014 The 2013 Deferred Bonus Plan (approved February 2014) \u2014 The 2015 Deferred Bonus Plan (approved May 2015) \u2014 The 2015 Sharesave scheme (approved May 2015) Share options are granted to Executive Directors and selected senior managers under the Company\u2019s Long Term Incentive Plans (LTIP), and Deferred Bonus Plans, and to other employees under the Share Option Schemes and Sharesave scheme. All option grants are at the discretion of the Remuneration Committee. All options granted are equity settled share options, but deferred share awards may be settled in cash at the option of the Remuneration committee. Options and RSUs granted under the 2007 and 2015 LTIP to Directors and other senior managers are subject to both revenue and market condition performance criteria and will vest only if, at the third anniversary of the grant, the performance criteria have been met. Failure to meet the minimum performance criteria by the third anniversary results in all the granted options lapsing. The performance criteria are described in the Directors\u2019 Remuneration Report. LTIP awards made to date are exercisable at either par or at nil cost on the third anniversary of the date of grant, and lapse 10 years after being granted. For Directors, options granted between 2019 and 2021 also have a 2 year holding period post vesting. Restricted stock units (RSUs) granted to employees under the 2015 LTIP are issued at nil cost. They are not subject to market condition performance criteria and the lives of the RSUs are ten years, after which the RSUs expire. RSUs granted under the 2015 Scheme cannot normally be exercised before the third anniversary of the date of grant. RSUs are valued based on the market price at the date of grant. Options granted under the 2007 Share Option Scheme have \ufb01xed exercise prices based on the market price at the date of grant. They are not subject to market condition performance criteria and the lives of the options are ten years, after which the options expire. Options granted prior to 2012 cannot normally be exercised before the third anniversary of the date of grant. Options granted under the 2007 Scheme during 2012 to 2014, with one exception, vest in tranches of 25% from the \ufb01rst to fourth anniversaries of the grant dates. Options granted under the 2015 Executive Share Option Scheme have \ufb01xed exercise prices based on the market price at the date of grant. They are not subject to market condition performance criteria and the lives of the options are ten years, after which the options expire. Options granted under the 2015 Scheme cannot normally be exercised before the third anniversary of the date of grant. Options granted under the 2015 Sharesave Scheme have \ufb01xed exercise prices based on the market price at the date of grant. They are not subject to market condition performance criteria and the lives of the options are four years, after which the options expire and the cash saved is returned. Options cannot be exercised before the third anniversary of the date of grant. Share options outstanding at 31 December 2022 have the following expiry date and exercise prices: Options granted to employees under the Oxford Biomedica 2007 and 2015 Share Option Schemes 2022  Number of shares 2021  Number of shares Exercise price  per share Date from  which exercisable Expiry date \u2013  5,560 115p to 155p Vested 08/05/22 to 21/12/22 12,860 15,155 80p to 140p Vested 22/05/23 to 19/11/23 16,518 16,518 100p to 200p Vested 03/06/24 to 17/10/24 38,170\u2009\u00b9 39,873\u00b9 490p Vested 13/03/25 to 10/06/25 52,689\u2009\u00b9 55,309\u00b9 275p Vested 16/05/26 to 13/10/26 95,927\u2009\u00b9 106,026\u00b9 495p Vested 13/07/2017 to 13/07/27 120,903\u2009\u00b9 141,060\u00b9 502p to 904p Vested  15/02/2028 to 07 08 2028 326,889\u2009\u00b9 379,808\u00b9 618p to 705p Vested  04/01/2029 to 12/09/2029 458,426\u2009\u00b9 520,824\u2009\u00b9 760p to 817p 26/06/2023 to 05/10/2023 26/06/2030 to 05/10/2030 1,122,382 1,281,133 \u00b9   Options granted under the 2015 Executive share option scheme. Options granted to employees under the Oxford Biomedica 2015 Sharesave scheme 2022  Number of shares 2021  Number of shares Exercise price  per share Date from  which exercisable Expiry date \u2013 29,682 725p 10/10/21 10/04/22 187,396 237,069 422p 09/10/22 09/04/23 98,670 154,756 672p 31/10/23 30/04/24 71,109 143,345 1,226p 31/10/24 30/04/25 623,097 \u2013 294p 19/10/25 19/04/26 980,272 564,852 Options granted under the Oxford Biomedica 2007 and 2015 Long Term Incentive Plans 2022  Number of shares 2021  Number of shares Exercise price  per share Date from  which exercisable Expiry date 55,774 55,774 50p Vested 12/06/2023 29,524 29,524 50p Vested 20/06/2024 to 17/10/2024 43,824 43,824 0p Vested 10/01/2025 82,185 82,185 0p Vested 16/05/2026 123,754\u2009\u00b2 143,294\u2009\u00b2 0p Vested 17/07/2027 to 25/09/2027 39,652\u2009\u00b2 62,913\u2009\u00b9 , \u00b2 0p Vested 15/02/2028 to 07/08/2028 109,658\u2009\u00b9 , \u00b2 282,093\u00b9 , \u00b2 0p Vested 18/04/2029 to 12/09/2029 260,577\u2009\u00b9 , \u00b2 260,577\u00b9 , \u00b2 0p 26/06/2023 26/06/2030 263,297\u2009\u00b9 , \u00b2 263,297\u00b9 , \u00b2 0p 08/06/2024 08/06/2031 205,562\u2009\u00b3 234,883\u00b9 , \u00b2 0p 08/06/2024 08/06/2031 460,986\u2009\u00b9 , \u00b2 \u2013 0p 29/04/2025 29/04/2032 1,403,889\u2009\u00b3 \u2013 0p  10/09/2022 to 20/12/2026 18/03/2032 to 20/12/2032 3,078,692 1,590,364 5,181,346 3,436,268 \u00b9   These LTIP awards will vest provided that performance conditions speci\ufb01ed in the Directors\u2019 Remuneration Report are met. \u00b2   Options granted under the 2015 LTIP. \u00b3   Restricted Share Options (RSUs) granted under the 2015 LTIP issued to employees vesting over 3 years Deferred Share Awards The Executive Directors and certain other senior managers have been awarded deferred bonuses in the form of share options. These options are exercisable at nil p on either the \ufb01rst three anniversaries of the grant or the third anniversary of the grant dependent on the option conditions. Options with a value of \u00a31,029,000 vested during 2022 (2021: \u00a31,037,000). The options granted under the 2013 Deferred Bonus Plan will be satis\ufb01ed by market-purchased shares held by the Oxford Biomedica Employee Bene\ufb01t Trust (EBT). As at 31 December 2022, all shares held by the EBT had vested. The EBT is consolidated at year end with the shares held in trust until the exercise of the option. During the year 77,376 shares (2021: nil) from the EBT were exercised. Deferred bonus share awards are valued at the market price on the date of grant. The options granted under the 2015 Deferred Bonus Plan will be satis\ufb01ed by new issue shares at the time of exercise. Options granted to employees under the Oxford Biomedica 2013 and 2015 Deferred Bonus Plan 2022  Number of shares 2021  Number of shares Exercise price  per share Date from  which exercisable Expiry date 68,725 68,725 0p Exercisable 15/06/24 and 14/10/24 27,402 27,402 0p Exercisable 04/05/25 32,010 32,010 0p Exercisable 14/05/26 27,696 27,696 0p Exercisable 11/07/27 31,815 36,205 0p Exercisable 07/08/28 67,793 67,793 0p Exercisable 18/04/29 64,701 65,576 0p 20/06/21 to 20/06/23 20/06/30 58,943 58,943 0p 08/06/22 to 08/06/24 20/06/31 175,958 \u2013 0p 29/04/23 to 29/04/25 29/04/32 555,043 384,350 National insurance liability Certain options granted to UK employees could give rise to a national insurance (NI) liability on exercise. A liability of \u00a3642,000 (2021: \u00a31,305,000) is included in accruals for the potential NI liability accrued to 31 December on exercisable options that were above water based on the year-end share price of 443p (2021: 1,230p) per share. 28, Share based payments Sharesave Scheme awards  (Model used: Black Scholes) Options awarded  19 Oct 2022 Share price at grant date 300.00p Exercise price 294.40p Vesting period (years) 3 Total number of shares under option 626,154 Expected volatility (weighted average) 48.08% Expected life (years) 3 Risk free rate (weighted average) 3.49% Fair value per option 109.61p LTIP awards (Model used: Monte Carlo) LTIPs awarded 29 Apr 2022 LTIPs awarded  18 Mar 2022 Share price at grant date 570p 697p Exercise price 0p 0p Vesting period (years) 3 3 Total number of shares under option 474,117 268,790 Expected volatility (weighted average) 46.03% 44.78% Expected life (years) 3 3 Risk free rate (weighted average) 1.65% 0.21% Fair value per option 278p 475p The tables below show the movements in the Share Option Scheme, Sharesave scheme and the LTIP during the year, together with the  related weighted average exercise prices. Excluding the LTIP, RSU and Deferred Bonus awards which are exercisable at par/nil value, the weighted average exercise price for options  granted during the year was 294.4p (2021: 1,226.0p). 290,022 options were exercised in 2022 (2021: 471,520), including 4,390 of deferred bonus options (2021: 69,454). The total charge for the year relating to employee share-based payment plans was \u00a36,471,000 (2021: \u00a33,523,000), all of which related to equity-settled share  based payment transactions. 2022 2021 Share options excluding LTIP Number Weighted average exercise price Number Weighted average exercise price Outstanding at 1 January 1,845,904 695.5p 2,118,041 548.7p Granted 626,154 294.4p 144,079 1,226.0p Forfeited (182,828) 718.5p (147,282) 706.4p Exercised (19,195) 467.0p (252,676) 577.5p Cancelled (167,381) 829.9p (16,258) 587.7p Outstanding at 31 December 2,102,654 565.3p 1,845,904 695.5p Exercisable at 31 December 524,463 520.0p 410,102 588.4p Exercisable and where  market price exceeds  exercise price at 31 December 269,463 520.0p 410,102 588.4p LTIP awards (options exercisable at par value 1p or nil cost) 2022 Number 2021 Number Outstanding at 1 January 1,590,364 1,361,829 Granted 2,053,897 507,604 Expired (299,132) (168,796) Exercised (266,437) (110,273) Outstanding at 31 December  3,078,692  1,590,364 Exercisable at 31 December 484,371 549,514 Range of exercise prices Weighted average exercise price Number of shares Weighted average  remaining life  (years) Weighted average exercise price Number of shares Weighted average  remaining life  (years) LTIP: Exercisable at par or at nil cost 1.4p 3,078,692 8.2 6.8p 1,590,364 6.9 Deferred bonus: Exercisable at par or at nil cost 0p 555,043 6.5 0p 384,350 6.3 Options: 50p to 150p 101p 21,822 0.9 101p 25,197 1.8 150p to 250p 200p 7,556 1.8 183p 12,036 1.9 250p to 350p 293p 675,786 9.3 275p 56,228 4.3 350p to 650p 452p 321,493 5.6 454p 393,529 6.7 650p+ 782p 1,075,997 7.0 798p 1,358,914 8.1 At 31 December 2021    5,736,389 3,820,618 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfSharebasedPaymentArrangementsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-473": {
   "value": "29, Accumulated losses Group Company Notes 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 At 1 January (165,806) (188,723) (128,584) (126,143) (Loss)/pro\ufb01t for the year (39,157) 19,011 (4,804) (2,366) Share based payments 5,922 3,523 \u2013 \u2013 Acquisition of NCI without a change in control 37 400 \u2013 \u2013 \u2013 Deferred tax on share options 125 458 \u2013 \u2013 Exercise of nil cost option (29) (75) (15) (75) At 31 December (198,545) (165,806) (133,403) (128,584) \u00b9   The credit to accumulated losses is made up out of the charge for the year relating to employee share-based payment plans of \u00a35,442,000 (2021: \u00a32,486,000) (note 28), \u00a31,029,000 (2021: \u00a31,037,000) related to the vesting of deferred share awards made to executive directors and senior managers less \u00a3549,000 of share based payment charge allocated to Non controlling interests. Neither the Company nor its subsidiary undertakings had reserves available for distribution at 31 December 2022 or 31 December 2021. 30, Other reserves Group Translation Reserve  \u00a3\u2019000 Other equity \u00a3\u2019000 Merger reserve \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 \u2013 \u2013 2,291 2,291 Put option recognition \u2013 (38,996) \u2013 (38,996) Put option revaluation \u2013 3,993 \u2013 3,993 Foreign currency translation differences 7,825 \u2013 \u2013 7,825 At 31 December 2022 7,825 (35,003) 2,291  (24,887) Group Merger reserve \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 2,291 2,291 At 31 December 2022 2,291 2,291 At 1 January 2021 2,291 2,291 At 31 December 2021 2,291 2,291 Company Merger reserve \u00a3\u2019000 Share Scheme Reserve \u00a3\u2019000 Total \u00a3\u2019000 At 1 January 2022 1,580 18,792 20,372 Credit in relation to employee share schemes \u2013 6,471 6,471 At 31 December 2022 1,580 25,263 26,843 At 1 January 2021 1,580 15,269 16,849 Credit in relation to employee share schemes \u2013 3,523 3,523 At 31 December 2021 1,580 18,792 20,372 Merger reserve The Group merger reserve at 31 December 2022 and 2021 comprised \u00a3711,000 arising from the consolidation of Oxford Biomedica (UK) Ltd using the merger method of accounting in 1996, and \u00a31,580,000 from the application of merger relief to the purchase of Oxxon Therapeutics Limited in 2007. Share scheme reserve Options over the Company\u2019s shares have been awarded to employees of Oxford Biomedica (UK) Ltd., Oxford Biomedica Solutions and Oxford Biomedica (US) Inc. In accordance with IFRS 2 \u2019Share-based Payment\u2019 the expense in respect of these awards is recognised in the subsidiaries\u2019 \ufb01nancial statements (see note 27). In accordance with IFRS 2, the Company has treated the awards as a capital contribution to the subsidiaries, resulting in an increase in the cost of investment of \u00a36,471,000 (2021: \u00a33,523,000) (see note 14) and  a corresponding credit to reserves. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfReservesAndOtherEquityInterestExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-445": {
   "value": "31, Cash \ufb02ows from operating activities Reconciliation of loss before tax to net cash used in operations: Group Company 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Continuing operations (Loss)/pro\ufb01t before taxation (45,976) 19,880 (4,804) (2,366) Adjustment for: Depreciation 20,271 12,435 323 \u2013 Amortisation of intangible assets 6,088 21 \u2013 \u2013 Loss on disposal of property, plant and equipment 28 \u2013 \u2013 \u2013 (Gain) on sale and leaseback (21,389) \u2013 \u2013 \u2013 Loss on disposal of intangible 27 \u2013 \u2013 \u2013 Amortisation of loan fees 588 \u2013 588 \u2013 Finance costs 15,756 888 14,033 \u2013 Charge in relation to employee share schemes 6,471 3,981 \u2013 \u2013 Non-cash loss 51 165 \u2013 \u2013 Changes in working capital: (Increase)/decrease in trade and other receivables (17,876) 6,891 \u2013 \u2013 Increase/(decrease) in trade and other payables 16,959 (657) 6 17 Decrease in deferred income (691) (867) \u2013 \u2013 Increase/(decrease)/ in contract liabilities 5,852 (15,667) \u2013 \u2013 Decrease/(increase) in inventory 688 (2,609) \u2013 \u2013 Net cash (used in)/generated from operations (13,173) 24,461 10,146 (2,349) ",
   "dimensions": {
    "concept": "oxfordbiomedicaplc:DisclosureOfCashFlowsFromOperatingActivities",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-446": {
   "value": "32, Pension commitments The Group operates a de\ufb01ned contribution pension scheme for its directors and employees. The assets of the scheme are held in  independently administered funds. The pension cost charge of \u00a33,560,000 (2021: \u00a32,839,000) represents amounts payable by the Group  to the scheme. Contributions of \u00a3403,000 (2021: \u00a3392,000), included in accruals, were payable to the scheme at the year-end. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfEmployeeBenefitsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-474": {
   "value": "32, Pension commitments The Group operates a de\ufb01ned contribution pension scheme for its directors and employees. The assets of the scheme are held in  independently administered funds. The pension cost charge of \u00a33,560,000 (2021: \u00a32,839,000) represents amounts payable by the Group  to the scheme. Contributions of \u00a3403,000 (2021: \u00a3392,000), included in accruals, were payable to the scheme at the year-end. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfDefinedContributionPlansExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-447": {
   "value": "33, Leases The additions to right of use assets during the year relate to lease of at Patriot\u2019s Park (\u00a325.0 million) as part of the acquisition of Oxford  Biomedica Solutions, and \u00a313.0 million related to the new lease liabilities as a result of the sale and leaseback of the Windrush Court facility  and the Wallingford Warehouse.  The additions in leases entered into during the year relate to those at Patriot\u2019s Park \u00a325.0 million respectively as part of the acquisition and  \u00a339.2 million related to the new lease liabilities as a result of the sale and leaseback of the Windrush Court facility, and the lease of the Wallingford Warehouse.  Sale and leaseback of Windrush Court The Windrush Court building was owned and then sold by Oxford Biomedica (UK) Ltd in October 2022, after which the building was  immediately leased under a 15 year lease by Oxford Biomedica PLC on the same day. In the Company\u2019s individual accounts, the Company  has accounted for the lease as a standalone lease with the resultant lease liability and matching right of use asset, whilst Oxford Biomedica  (UK) Ltd has accounted for the transaction as a standalone sale of an asset. However, from a Group perspective the transaction has been  accounted for as a sale and leaseback transaction as both companies form part of the same group and both the sale and leaseback was  negotiated and entered into at the same time.  The Group leases land and buildings and IT equipment. Information about leases for which the Group is a lessee is presented below: Right-of-use assets: Group  Property \u00a3\u2019000 Equipment \u00a3\u2019000 IT equipment \u00a3\u2019000 Total \u00a3\u2019000 Balance at 1 January 2022 11,450 2,780 36 14,266 Acquisitions through business combinations 24,974 \u2013 \u2013 24,974 Foreign exchange 2,072 \u2013 \u2013 2,072 Additions 13,038 \u2013 \u2013 13,038 Change in estimate (1,349) \u2013 \u2013 (1,349) Depreciation charge for the period (4,185) (730) (36) (4,951) Balance at 31 December 2022 46,000 2,050 0 48,050 Company  Property \u00a3\u2019000 Equipment \u00a3\u2019000 IT equipment \u00a3\u2019000 Total \u00a3\u2019000 Balance at 1 January 2022 \u2013 \u2013 \u2013 \u2013 Additions 39,717 \u2013 \u2013 39,717 Depreciation charge for the period (323) \u2013 \u2013 (323) Balance at 31 December 2022 39,394 \u2013 \u2013 39,394 Lease liabilities: Group Company Maturity analysis \u2013 contractual undiscounted cash \ufb02ows 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Less than one year 9,179 1,590 3,500 \u2013 One to \ufb01ve years 43,035 5,883 13,300 \u2013 Six to ten years 42,224 5,071 23,491 \u2013 More than ten years  25,059 913 22,935 \u2013 Total undiscounted cash \ufb02ows at 31 December 2022 119,497 13,457 63,226 \u2013 Lease liabilities included in the Statement of Financial Position 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Current 3,295 853 683 \u2013 Non-current 71,206 8,488 34,939 \u2013 Total lease liabilities at 31 December 2021 74,501 9,341 35,622 \u2013 Amounts recognised in the pro\ufb01t or (loss) 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Interest on lease liabilities 3,124 873 477 \u2013 Expense relating to short term leases 178 369 \u2013 \u2013 Amounts recognised in the statement of cash \ufb02ows 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Total cash out\ufb02ow for leases 4,244 5,393 422 \u2013 ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfLeasesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-481": {
   "value": "34, Contingent liabilities and capital commitments The Group has a letter of credit \u00a31,405,000 (2021: nil) related to the deposit on the Patriots park lease which is disclosed within Trade and other receivables in non current assets. The Group had commitments of \u00a32,882,000 for capital expenditure for leasehold improvements and plant and equipment not provided for in the \ufb01nancial statements at 31 December 2022 (2021: \u00a33,974,000). ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfCommitmentsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-475": {
   "value": "34, Contingent liabilities and capital commitments The Group has a letter of credit \u00a31,405,000 (2021: nil) related to the deposit on the Patriots park lease which is disclosed within Trade and other receivables in non current assets. The Group had commitments of \u00a32,882,000 for capital expenditure for leasehold improvements and plant and equipment not provided for in the \ufb01nancial statements at 31 December 2022 (2021: \u00a33,974,000). ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfContingentLiabilitiesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-448": {
   "value": "34, Contingent liabilities and capital commitments The Group has a letter of credit \u00a31,405,000 (2021: nil) related to the deposit on the Patriots park lease which is disclosed within Trade and other receivables in non current assets. The Group had commitments of \u00a32,882,000 for capital expenditure for leasehold improvements and plant and equipment not provided for in the \ufb01nancial statements at 31 December 2022 (2021: \u00a33,974,000). ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-449": {
   "value": "35, Acquisition of subsidiary<span class=\"_ _2b2\"> </span>On 10 March 2022, the Group acquired 7<span class=\"_ _25\"></span>4% of the shares and voting interests in Oxfor<span class=\"_ _25\"></span>d Biomedica Solutions LLC for US$130 million.<span class=\"ls1\"> </span>As a result, the Group\u2019s equity interest granted it control of Oxf<span class=\"_ _25\"></span>ord Biomedica Solutions. Immediately following the acquisition, the Group acquired a further 6% interest in Oxford Biomedica Solutions through an equity investment of \u00a338<span class=\"_ _25\"></span>.2 million (US$50 million) leading to<span class=\"ls1\"> </span>a dilution in the interests of Homology Medicines from 26% to 20% (refer note 37).<span class=\"_ _2b2\"> </span>Included in the identi\ufb01able assets and liabilities acquired at the date of acquisition of Oxford Biomedica Solutions ar<span class=\"_ _25\"></span>e inputs, production processes and an organised workforce. The Group has determined that together the acquir<span class=\"_ _25\"></span>ed inputs and processes signi\ufb01cantly contribute to the Group\u2019s ability to create revenue. The Group has concluded tha<span class=\"_ _25\"></span>t the acquired inputs and processes is a business.<div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs8cd\">A. Consideration T<span class=\"_ _27\"></span>ransferred<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8ce\">The following table summarises the acquisition date fair value of each major class of consideration transferred:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8cf\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8d0\">Cash <span class=\"_ _298\"> </span>99<span class=\"_ _25\"></span>,206<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs8d1\">T<span class=\"_ _3\"></span>otal Consideration<span class=\"_ _299\"> </span><span class=\"wsa\">99,206<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs8d2\">B. Acquisition related expenses:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8d3\">The Group incurred acquisition related legal and due diligence expenses of \u00a35<span class=\"_ _25\"></span><span class=\"_ _2b2\">.1 million (2021: \u00a31.2 million) which is included in<span class=\"_ _2b2\"> </span></span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8d4\">Administrative expenses.<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs8d5\">C. Identi\ufb01able assets acquired and liabilities assumed:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8d6\">The following table summarises the recognised amounts of assets acquired and liabilities assumed at the date of acquisition:<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8d7\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8d8\">Property<span class=\"_ _25\"></span>, plant &amp; equipment<span class=\"_ _26e\"> </span><span class=\"wsa\">58,945<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8d9\">Intangible assets<span class=\"_ _1e5\"> </span><span class=\"wsa\">102,<span class=\"_ _25\"></span>869<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8da\">Inventory<span class=\"_ _29a\"> </span>3,<span class=\"_ _3\"></span>476<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8db\">Prepaid expenses<span class=\"_ _29b\"> </span><span class=\"wsa\">229<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8dc\">Lease Liabilities<span class=\"_ _12c\"> </span><span class=\"wsa\">(24<span class=\"_ _25\"></span>,97<span class=\"_ _25\"></span>4)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8dd\">Deferred tax liabilities<span class=\"_ _29c\"> </span><span class=\"wsa\">(7<span class=\"_ _3\"></span>,307)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs8de\">T<span class=\"_ _3\"></span>otal identi\ufb01able net assets acquired:<span class=\"_ _ba\"> </span><span class=\"wsa\">133,238<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8df\">The valuation techniques used for measuring the fair value of material assets acquired were as follows:<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa ws0 gs8e0\">Assets acquired<span class=\"_ _295\"> </span>Valuation technique<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e1\">Property plant and equipment<span class=\"_ _71\"> </span>Market comparison technique and cost technique \u2013 The valuation model considers market prices <span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e2\">for similar items when they are available, and depreciated replacement cost when appr<span class=\"_ _25\"></span>opriate. <span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e3\">Depreciated replacement cost re\ufb02ects adjustments for physical deterioration as well as functional<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e4\">and economic obsolescence<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e5\">Intangible assets<span class=\"_ _29d\"> </span>Multi-period excess earnings method \u2013 The multi-period excess earnings method considers the<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e6\">present value of net cash \ufb02ows expected to be generated by the client relationships, by excluding<span class=\"ls1\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e7\">any cash \ufb02ows related to contributory assets.<span class=\"ls1\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse wsd gs8e8\">Inventory<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8e9\">Market comparison \u2013 T<span class=\"_ _27\"></span>o determine the fair value of the inventory, the Group obtained current prices<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8ea\">for each of the items making up the transferred inventory<span class=\"_ _25\"></span>. <span class=\"ls1\"> </span></div><div class=\"t m1 h10 ffa fs4 fca sc0 lse ws0 gs8eb\">D. Goodwill<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa wsa gs8ec\">\u00a3\u2019000<span class=\"_ _2b2\"> </span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8ed\">Consideration transferred <span class=\"_ _236\"> </span><span class=\"wsa\">99<span class=\"_ _25\"></span>,206<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8ee\">Interest in the identi\ufb01able net assets of non-controlling interests<span class=\"_ _29e\"> </span><span class=\"wsa\">34,<span class=\"_ _25\"></span>642<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 ha ff9 fs5 fc3 sc0 lsa ws0 gs8ef\">Fair value of identi\ufb01able assets<span class=\"_ _29f\"> </span><span class=\"wsa\">(133,238)<span class=\"_ _2b2\"> </span></span></div><div class=\"t m1 h9 ffa fs5 fc3 sc0 lsa wsa gs8f0\">Goodwill<span class=\"_ _2a0\"> </span>610<span class=\"_ _2b2\"> </span></div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8f1\">The goodwill is attributable mainly to the skills and technical talent of Oxford Biomedica Solutions\u2019 workforce. None of the goodwill<span class=\"_ _2b2\"> </span> </div><div class=\"t m1 h7 ff9 fs4 fc3 sc0 lse ws0 gs8f2\">recognised is expected to be deductible for tax purposes.<span class=\"_ _2b2\"> </span></div>37<span class=\"_ _3\"></span>, Acquisition of Non-controlling interest<span class=\"_ _2b2\"> </span>On 10 March 2022, the Group acquired an additional 6% interest in Oxfor<span class=\"_ _25\"></span>d Biomedica Solutions through an equity investment in Oxford Biomedica Solutions of \u00a338.2 million (US$50 million), increasing its ownership from 7<span class=\"_ _3\"></span>4% to 80%, leading to a dilution in the interests<span class=\"_ _2\"></span><span class=\"ls1\"> </span>of Homology Medicines from 26% to 20% . The carrying amount of Oxford Biomedica Solutions\u2019 net assets in the Group\u2019s consolidated \ufb01nancial statements on the date of the acquisition was \u00a3133.2 million.<span class=\"_ _2b2\"> </span>\u00a3\u2019000<span class=\"_ _2b2\"> </span>Carry amount of NCI acquired<span class=\"_ _2b0\"> </span><span class=\"wsa\">400<span class=\"_ _2b2\"> </span></span>Consideration paid to NCI<span class=\"_ _1fa\"> </span><span class=\"ls1\">\u2013<span class=\"_ _2b2\"> </span></span>Increase in equity attributable to owners of the Company <span class=\"_ _2ae\"> </span><span class=\"wsa\">400<span class=\"_ _2b2\"> </span></span>The increase in equity attributable to owners of the Company comprised solely of an increase to retained earnings.<span class=\"_ _2b2\"> </span>",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfBusinessCombinationsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-476": {
   "value": "36, Non-controlling interest The proportion of the identi\ufb01able net assets of the Non-controlling interest in Oxford Biomedica Solutions on acquisition was determined to be \u00a334,642,000. Following a review of the accounting for the acquisition of Oxford Biomedica Solutions it was identi\ufb01ed that the fair value initially attributed to the non-controlling interest was not appropriate. As a result, the group has elected to change its accounting policy for the initial recognition of non-controlling interest from fair value at date of acquisition to the holders' proportionate interest in the recognised amount of the identi\ufb01able net assets of the acquiree. This valuation method better re\ufb02ects the value of the business attributable to the non-controlling shareholders. This has resulted in a reduction in the initial value of non-controlling interest from \u00a348.4 million to \u00a334.6 million, a corresponding reduction of 'Goodwill' recognised on acquisition from \u00a314.4 million to \u00a30.6 million and a reduction in the 'Acquisition of NCI without a change in control' of \u00a311.3 million to \u00a30.4 million. The overall impact of this to net assets is \u00a313.8 million with no impact to pro\ufb01t or loss recognised in the period.The following table summarises the information relating to the Group\u2019s subsidiary that has material NCI: 2022 \u00a3\u2019000 NCI percentage 20% Non current assets 171,419 Current assets 29,732 Non-current liabilities (7,473) Current liabilities (35,979) Net assets\u00b9 157,699 Net assets attributable to NCI 31,539 \u00b9 Net assets include the impact of share based payments. Revenue 23,722 Pro\ufb01t (30,011) OCI 13,756 Total comprehensive income (16,255) Pro\ufb01t allocated to NCI (6,002) OCI allocated to NCI 2,750 Cash \ufb02ows from operating activities (9,732) Cash \ufb02ows from investment activities 30,867 Cash \ufb02ow from \ufb01nancing activities (dividends to NCI: nil) (2,293) Net increase in cash and cash equivalents 18,842 There was no Non-controlling interest in 2021. 37, Acquisition of Non-controlling interest On 10 March 2022, the Group acquired an additional 6% interest in Oxford Biomedica Solutions through an equity investment in Oxford Biomedica Solutions of \u00a338.2 million (US$50 million), increasing its ownership from 74% to 80%, leading to a dilution in the interests of Homology Medicines from 26% to 20% . The carrying amount of Oxford Biomedica Solutions\u2019 net assets in the Group\u2019s consolidated \ufb01nancial statements on the date of the acquisition was \u00a3133.2 million. \u00a3\u2019000 Carry amount of NCI acquired 400 Consideration paid to NCI \u2013 Increase in equity attributable to owners of the Company  400 The increase in equity attributable to owners of the Company comprised solely of an increase to retained earnings. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfNoncontrollingInterestsExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-450": {
   "value": "38, Related party transactions Identity of related parties As at 31 December 2022, the Group consisted of:  \u2014 a parent, Oxford Biomedica plc,  \u2014 one wholly-owned UK trading subsidiary Oxford Biomedica (UK) Limited, the principal trading company,  \u2014 one US trading subsidiary, 80% owned, Oxford Biomedica Solutions LLC,  \u2014 one US subsidiary 100% owned, Oxford Biomedica (US) Inc,  \u2014 one Irish wholly-owned subsidiary of the parent company, Oxford Biomedica (Ireland) Ltd,   \u2014 one dormant subsidiary, Oxxon Therapeutics Limited which was acquired and became dormant in 2007 when its assets and trade  were transferred to Oxford Biomedica (UK) Limited, and  \u2014 one additional dormant subsidiary, Invivusbio Limited, which changed its name on 18 January 2023 from OXB Solutions Limited. The registered office of the Company, it\u2019s UK subsidiaries and Oxford Biomedica (US) Inc. is Windrush Court, Transport Way, Oxford  OX4 6LT. The registered office of Oxford Biomedica (Ireland) Ltd is Earlsfort Terrace, Dublin 2, DO2 T380, Ireland. The registered office  of OXB Solutions LLC is 1 Patriots Park, Bedford, MA 01730, USA. The parent company is responsible for \ufb01nancing and setting Group strategy. Oxford Biomedica (UK) Limited carries out the UK elements  of the Group strategy, employs all the UK staff including the Executive Directors, and owns and manages all of the Group\u2019s intellectual  property. Oxford Biomedica Solutions carries out the US equivalent activities. The proceeds from the issue of shares by the parent are passed from Oxford Biomedica plc to Oxford Biomedica (UK) Limited as a loan,  and Oxford Biomedica (UK) Limited manages Group funds and makes payments, including the expenses of the parent company. Company: transactions with subsidiaries 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Purchases: Parent company expenses paid by subsidiary (10,941) (749) Cash management: Cash loaned by parent to subsidiary Oxford Biomedica (UK) Limited  15,780 12,000 Cash loaned by parent to subsidiary Oxford Biomedica (US) Inc. 148,764 \u2013 The loans from Oxford Biomedica plc to Oxford Biomedica (UK) Limited and Oxford Biomedica (US) Inc. are unsecured and interest free.  The loans are not due, planned or expected for repayment within 12 months of the year end. The year-end balance on the loans was: Company: year-end balance of loan 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Loan to subsidiary Oxford Biomedica (UK) Limited 278,091 273,253 Oxford Biomedica (US) Inc 148,764 \u2013 The investment in the subsidiary, of which the loan forms part, has been impaired by \u00a3126.0 million (note 14) in previous years. Transactions Balance Outstanding Other Related Party Transactions 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Sales of goods and services: Homology Medicines23,252 \u2013  4,334 \u2013 Purchase of services: Homology Medicines 4,258 \u2013 1,158 \u2013 Other: Homology Medicines \u2013 rental income 1,085 \u2013 424 \u2013 In addition to the transactions above, options over the Company\u2019s shares have been awarded to employees of subsidiary companies.  In accordance with IFRS 2, the Company has treated the awards as a capital contribution to the subsidiaries, resulting in a cumulative  increase in the cost of investment of \u00a325,265,000 (2021: \u00a318,793,000). There were no transactions (2021: none) with Oxxon Therapeutics Limited. Company: transactions with related parties There were no other outstanding balances in respect of transactions with Directors and connected persons at 31 December 2022 (2021: none). Key person remuneration can be seen in note 5 of the \ufb01nancial statements. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfTransactionsBetweenRelatedPartiesExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-477": {
   "value": "38, Related party transactions Identity of related parties As at 31 December 2022, the Group consisted of:  \u2014 a parent, Oxford Biomedica plc,  \u2014 one wholly-owned UK trading subsidiary Oxford Biomedica (UK) Limited, the principal trading company,  \u2014 one US trading subsidiary, 80% owned, Oxford Biomedica Solutions LLC,  \u2014 one US subsidiary 100% owned, Oxford Biomedica (US) Inc,  \u2014 one Irish wholly-owned subsidiary of the parent company, Oxford Biomedica (Ireland) Ltd,   \u2014 one dormant subsidiary, Oxxon Therapeutics Limited which was acquired and became dormant in 2007 when its assets and trade  were transferred to Oxford Biomedica (UK) Limited, and  \u2014 one additional dormant subsidiary, Invivusbio Limited, which changed its name on 18 January 2023 from OXB Solutions Limited. The registered office of the Company, it\u2019s UK subsidiaries and Oxford Biomedica (US) Inc. is Windrush Court, Transport Way, Oxford  OX4 6LT. The registered office of Oxford Biomedica (Ireland) Ltd is Earlsfort Terrace, Dublin 2, DO2 T380, Ireland. The registered office  of OXB Solutions LLC is 1 Patriots Park, Bedford, MA 01730, USA. The parent company is responsible for \ufb01nancing and setting Group strategy. Oxford Biomedica (UK) Limited carries out the UK elements  of the Group strategy, employs all the UK staff including the Executive Directors, and owns and manages all of the Group\u2019s intellectual  property. Oxford Biomedica Solutions carries out the US equivalent activities. The proceeds from the issue of shares by the parent are passed from Oxford Biomedica plc to Oxford Biomedica (UK) Limited as a loan,  and Oxford Biomedica (UK) Limited manages Group funds and makes payments, including the expenses of the parent company. Company: transactions with subsidiaries 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Purchases: Parent company expenses paid by subsidiary (10,941) (749) Cash management: Cash loaned by parent to subsidiary Oxford Biomedica (UK) Limited  15,780 12,000 Cash loaned by parent to subsidiary Oxford Biomedica (US) Inc. 148,764 \u2013 The loans from Oxford Biomedica plc to Oxford Biomedica (UK) Limited and Oxford Biomedica (US) Inc. are unsecured and interest free.  The loans are not due, planned or expected for repayment within 12 months of the year end. The year-end balance on the loans was: Company: year-end balance of loan 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Loan to subsidiary Oxford Biomedica (UK) Limited 278,091 273,253 Oxford Biomedica (US) Inc 148,764 \u2013 The investment in the subsidiary, of which the loan forms part, has been impaired by \u00a3126.0 million (note 14) in previous years. Transactions Balance Outstanding Other Related Party Transactions 2022 \u00a3\u2019000 2021 \u00a3\u2019000 2022 \u00a3\u2019000 2021 \u00a3\u2019000 Sales of goods and services: Homology Medicines23,252 \u2013  4,334 \u2013 Purchase of services: Homology Medicines 4,258 \u2013 1,158 \u2013 Other: Homology Medicines \u2013 rental income 1,085 \u2013 424 \u2013 In addition to the transactions above, options over the Company\u2019s shares have been awarded to employees of subsidiary companies.  In accordance with IFRS 2, the Company has treated the awards as a capital contribution to the subsidiaries, resulting in a cumulative  increase in the cost of investment of \u00a325,265,000 (2021: \u00a318,793,000). There were no transactions (2021: none) with Oxxon Therapeutics Limited. Company: transactions with related parties There were no other outstanding balances in respect of transactions with Directors and connected persons at 31 December 2022 (2021: none). Key person remuneration can be seen in note 5 of the \ufb01nancial statements. ",
   "dimensions": {
    "concept": "ifrs-full:DisclosureOfRelatedPartyExplanatory",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  },
  "fact-5": {
   "value": "Windrush Court, Transport Way Oxford OX4 6LT, United Kingdom",
   "dimensions": {
    "concept": "ifrs-full:AddressOfRegisteredOfficeOfEntity",
    "language": "en",
    "entity": "scheme:213800S1GVQNXQ15K851",
    "period": "2022-01-01T00:00:00/2023-01-01T00:00:00"
   }
  }
 }
}