<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:d5d648d4-c7cf-45b8-b3e1-7da06bf7f803,g:7a98e477-fdef-481e-96b3-93eebc4b1ee6-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:arcroleRef arcroleURI="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd#wider-narrower"/>
  <link:roleRef roleURI="http://ptv.com/role/StatementofchangesinequityStatement" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#StatementofchangesinequityStatement"/>
  <link:definitionLink xlink:role="http://ptv.com/role/StatementofchangesinequityStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityAbstract_b66ec9aa-503c-4c6a-8646-86580848c7ca" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_StatementOfChangesInEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityTable_a4587050-1754-4cd7-932c-f60c9cfa0885" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_StatementOfChangesInEquityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_b66ec9aa-503c-4c6a-8646-86580848c7ca" xlink:to="loc_ifrs-full_StatementOfChangesInEquityTable_a4587050-1754-4cd7-932c-f60c9cfa0885" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComponentsOfEquityAxis_0737fa7a-6e4f-41ef-b6e2-b468d9fea0ea" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComponentsOfEquityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_StatementOfChangesInEquityTable_a4587050-1754-4cd7-932c-f60c9cfa0885" xlink:to="loc_ifrs-full_ComponentsOfEquityAxis_0737fa7a-6e4f-41ef-b6e2-b468d9fea0ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_ComponentsOfEquityAxis_0737fa7a-6e4f-41ef-b6e2-b468d9fea0ea" xlink:to="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapitalMember_e9437a93-f8aa-49e8-8985-d16adaa97067" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IssuedCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_IssuedCapitalMember_e9437a93-f8aa-49e8-8985-d16adaa97067" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremiumMember_48decb58-0971-4d7f-9f61-6b42ab071c12" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SharePremiumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_SharePremiumMember_48decb58-0971-4d7f-9f61-6b42ab071c12" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasurySharesMember_29490b26-fae2-4e6a-83a5-fa57cf83c50e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TreasurySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_TreasurySharesMember_29490b26-fae2-4e6a-83a5-fa57cf83c50e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MergerReserveMember_4a99870f-6250-4240-93c6-f15163d054b5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MergerReserveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_MergerReserveMember_4a99870f-6250-4240-93c6-f15163d054b5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_f6e6876d-1372-40ed-ba25-b76d268a6364" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_f6e6876d-1372-40ed-ba25-b76d268a6364" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReservesMember_b87ce4e8-f3ad-4a5e-9765-f9d112405692" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherReservesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_OtherReservesMember_b87ce4e8-f3ad-4a5e-9765-f9d112405692" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarningsMember_a6eeceff-ab89-4ef0-a525-3153901aded5" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_RetainedEarningsMember_a6eeceff-ab89-4ef0-a525-3153901aded5" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_8f13f7c5-26e2-47b5-ba7e-052a558e8719" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_8f13f7c5-26e2-47b5-ba7e-052a558e8719" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterestsMember_2a1c6d2e-5130-48eb-ab65-978bc8b054a2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncontrollingInterestsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_37fbb42f-ab56-40ed-8ad0-7d7c10fffc13" xlink:to="loc_ifrs-full_NoncontrollingInterestsMember_2a1c6d2e-5130-48eb-ab65-978bc8b054a2" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_StatementOfChangesInEquityLineItems"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityAbstract_b66ec9aa-503c-4c6a-8646-86580848c7ca" xlink:to="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NumberOfSharesIssued_770b0073-3ff3-4270-8e39-7f4d23809a30" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NumberOfSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_NumberOfSharesIssued_770b0073-3ff3-4270-8e39-7f4d23809a30" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_9a34a786-7707-4895-909e-262faca81ff4" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_Equity_9a34a786-7707-4895-909e-262faca81ff4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_9c72de77-9133-40df-bb65-a4856c20098f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_ProfitLoss_9c72de77-9133-40df-bb65-a4856c20098f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_356c0bad-4cc7-4c12-8703-bce173888c5e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_356c0bad-4cc7-4c12-8703-bce173888c5e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_71db288b-4cd3-4483-8de0-fcdeb32fefb7" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_ComprehensiveIncome_71db288b-4cd3-4483-8de0-fcdeb32fefb7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughChangeInEquityOfSubsidiaries_a1e912a5-45e0-40d0-9f9b-f37fd0a2264f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughChangeInEquityOfSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughChangeInEquityOfSubsidiaries_a1e912a5-45e0-40d0-9f9b-f37fd0a2264f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued_49fd2bdc-fb9d-4146-8e6d-1e4068c9f880" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued_49fd2bdc-fb9d-4146-8e6d-1e4068c9f880" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughExerciseOfOptions_2b4f1a4a-1512-47c5-bc7e-6f8aa93f3ba3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughExerciseOfOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughExerciseOfOptions_2b4f1a4a-1512-47c5-bc7e-6f8aa93f3ba3" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NumberOfTreasurySharesPurchased_a359fcf6-ab3f-4f2e-ac5c-593eef28b4db" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NumberOfTreasurySharesPurchased"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_NumberOfTreasurySharesPurchased_a359fcf6-ab3f-4f2e-ac5c-593eef28b4db" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfTreasuryShares_db9b0c20-9614-4f92-81e2-12bf8619202b" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfTreasuryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_PurchaseOfTreasuryShares_db9b0c20-9614-4f92-81e2-12bf8619202b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_6da000af-0395-44c4-b11a-a6708359fc5b" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_6da000af-0395-44c4-b11a-a6708359fc5b" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions_b06fb198-128f-4e3c-8e72-5aa5ca7a0582" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions_b06fb198-128f-4e3c-8e72-5aa5ca7a0582" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NumberOfOrdinarySharesIssuedToSettleShareBasedPaymentAwards_f20f45d3-c7eb-4882-9dcf-51fd38618ca9" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NumberOfOrdinarySharesIssuedToSettleShareBasedPaymentAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_NumberOfOrdinarySharesIssuedToSettleShareBasedPaymentAwards_f20f45d3-c7eb-4882-9dcf-51fd38618ca9" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_7e552d88-d3a4-40f3-a2e3-68e129a56910" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_7e552d88-d3a4-40f3-a2e3-68e129a56910" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_DecreaseInNonControllingFromExpirationOfShareOptionsInSubsidiary_f6cad0f3-8d5f-4e8d-b525-d1a1bfe5fec6" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_DecreaseInNonControllingFromExpirationOfShareOptionsInSubsidiary"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_DecreaseInNonControllingFromExpirationOfShareOptionsInSubsidiary_f6cad0f3-8d5f-4e8d-b525-d1a1bfe5fec6" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_da092cf3-0acd-4f57-8802-dc9ac01f8e2a" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_da092cf3-0acd-4f57-8802-dc9ac01f8e2a" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_4fe91b79-2946-4ddc-bef3-2dd553000dcb" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_4fe91b79-2946-4ddc-bef3-2dd553000dcb" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughAcquisitionOfSubsidiary_1caf357d-70f8-4dbb-9321-a411e757abbf" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughAcquisitionOfSubsidiary"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughAcquisitionOfSubsidiary_1caf357d-70f8-4dbb-9321-a411e757abbf" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_bf3be5e6-d513-4f72-bf4e-06a8092f70ba" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_bf3be5e6-d513-4f72-bf4e-06a8092f70ba" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_70d6012c-d755-40ed-9e52-40412b5f1ed1" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_e011019e-bbaa-473a-8eab-bf2288ee934a" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_70d6012c-d755-40ed-9e52-40412b5f1ed1" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NumberOfSharesIssued_bd637b7a-4088-4a64-bb62-4affb4b2ac60" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NumberOfSharesIssued"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_b992fbf1-1d32-43f6-8b7a-d037d594bf95" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://ptv.com/role/StatementofcashflowsindirectmethodParentheticalDetails" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#StatementofcashflowsindirectmethodParentheticalDetails"/>
  <link:definitionLink xlink:role="http://ptv.com/role/StatementofcashflowsindirectmethodParentheticalDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfCashFlowsAbstract_12ed782f-58da-41bb-a592-508205d08cb9" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_StatementOfCashFlowsTable_3caa84b0-5e8f-411c-9c96-0423b30158b0" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_StatementOfCashFlowsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ifrs-full_StatementOfCashFlowsAbstract_12ed782f-58da-41bb-a592-508205d08cb9" xlink:to="loc_ptv_StatementOfCashFlowsTable_3caa84b0-5e8f-411c-9c96-0423b30158b0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CounterpartiesAxis_287e0d2c-d8a8-427d-8911-ee66d0ecbdeb" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CounterpartiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ptv_StatementOfCashFlowsTable_3caa84b0-5e8f-411c-9c96-0423b30158b0" xlink:to="loc_ifrs-full_CounterpartiesAxis_287e0d2c-d8a8-427d-8911-ee66d0ecbdeb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CounterpartiesMember_93c4bb96-ae14-4f92-9e9c-110908a0edad" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CounterpartiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_CounterpartiesAxis_287e0d2c-d8a8-427d-8911-ee66d0ecbdeb" xlink:to="loc_ifrs-full_CounterpartiesMember_93c4bb96-ae14-4f92-9e9c-110908a0edad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_DeconsolidatedFormerSubsidiaryOperatingCompaniesMember_df3f28aa-560a-4baa-ad34-109b4b918620" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_DeconsolidatedFormerSubsidiaryOperatingCompaniesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_CounterpartiesMember_93c4bb96-ae14-4f92-9e9c-110908a0edad" xlink:to="loc_ptv_DeconsolidatedFormerSubsidiaryOperatingCompaniesMember_df3f28aa-560a-4baa-ad34-109b4b918620" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_StatementOfCashFlowsLineItems"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfCashFlowsAbstract_12ed782f-58da-41bb-a592-508205d08cb9" xlink:to="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_878c8284-faeb-421a-9b13-b9ade8f4a24e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_878c8284-faeb-421a-9b13-b9ade8f4a24e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPrepaidExpenses_3bf752e5-4f89-4603-8978-a9e58852fe76" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentPrepaidExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_CurrentPrepaidExpenses_3bf752e5-4f89-4603-8978-a9e58852fe76" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_ea8fe965-5903-48d6-b178-999375ed4941" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_ea8fe965-5903-48d6-b178-999375ed4941" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_9c4420bf-edba-4d80-853b-575229d3e1ef" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RightofuseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_RightofuseAssets_9c4420bf-edba-4d80-853b-575229d3e1ef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_7d79c9a6-4d5b-4c06-bef4-8c0df87d503e" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_7d79c9a6-4d5b-4c06-bef4-8c0df87d503e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentGovernmentGrants_3963e6a9-a596-41c2-99bb-a957e1409604" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentGovernmentGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_CurrentGovernmentGrants_3963e6a9-a596-41c2-99bb-a957e1409604" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LeaseLiabilities_38ce2461-ce5d-44d4-afe1-5596948c6ea3" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_LeaseLiabilities_38ce2461-ce5d-44d4-afe1-5596948c6ea3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_c7d06779-b6bf-451d-85f6-5558a206812f" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentPortionOfLongtermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_c7d06779-b6bf-451d-85f6-5558a206812f" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NotesAndDebenturesIssued_e7f1ea90-3471-471e-a7b5-38152d94a08d" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NotesAndDebenturesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_NotesAndDebenturesIssued_e7f1ea90-3471-471e-a7b5-38152d94a08d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapitalPreferenceShares_93d36fda-01f8-40b4-bff8-726844e021ab" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IssuedCapitalPreferenceShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_IssuedCapitalPreferenceShares_93d36fda-01f8-40b4-bff8-726844e021ab" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_OtherAssetsAndLiabilitiesNet_85cf530d-6288-47b7-b93b-13804fb498b0" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_OtherAssetsAndLiabilitiesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ptv_OtherAssetsAndLiabilitiesNet_85cf530d-6288-47b7-b93b-13804fb498b0" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_43312de1-5e6f-4713-8795-2487dba75ba8" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_NoncontrollingInterests_43312de1-5e6f-4713-8795-2487dba75ba8" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_36805c3d-26f1-4be3-8d29-4502e2acfda2" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_Equity_36805c3d-26f1-4be3-8d29-4502e2acfda2" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_28f62710-584f-4ca8-adf1-960f67b64760" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_28f62710-584f-4ca8-adf1-960f67b64760" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_94ee7e94-652b-42c3-8f36-d673ca8ed024" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_94ee7e94-652b-42c3-8f36-d673ca8ed024" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Cash_fb3a7f08-28eb-4949-8449-3b3e2485867a" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Cash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_ef1ee3fd-6071-4c8f-a28f-e745a9cdb8a2" xlink:to="loc_ifrs-full_Cash_fb3a7f08-28eb-4949-8449-3b3e2485867a" xlink:type="arc" order="16"/>
  </link:definitionLink>
  <link:roleRef roleURI="https://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="simple" xlink:href="https://www.esma.europa.eu/taxonomy/2022-03-24/esef_cor.xsd#esef_role-999999"/>
  <link:definitionLink xlink:role="https://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:href="https://www.esma.europa.eu/taxonomy/2022-03-24/esef_cor.xsd#esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_e482a097-28df-4faa-91d9-e4238c8cadf9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_e482a097-28df-4faa-91d9-e4238c8cadf9NotDimensionallyQualified" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromGovernmentGrants_890c77a1-8230-4a56-8aff-9d3e920cbea0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RevenueFromGovernmentGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RevenueFromGovernmentGrants_890c77a1-8230-4a56-8aff-9d3e920cbea0NotDimensionallyQualified" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_00dab07a-a7ad-4edb-b865-69cadceba46eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Revenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Revenue_00dab07a-a7ad-4edb-b865-69cadceba46eNotDimensionallyQualified" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_9448156a-3707-45c8-85ed-7d7f6b8fbfa0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_9448156a-3707-45c8-85ed-7d7f6b8fbfa0NotDimensionallyQualified" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_3b1f81ea-91eb-40a4-a042-ff567a8fe232NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_3b1f81ea-91eb-40a4-a042-ff567a8fe232NotDimensionallyQualified" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_24cbe0dc-b608-4ed1-8688-6a29bc9c6e54NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_24cbe0dc-b608-4ed1-8688-6a29bc9c6e54NotDimensionallyQualified" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_a6b1ffa3-f973-4baf-918f-d4cccfc80824NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_a6b1ffa3-f973-4baf-918f-d4cccfc80824NotDimensionallyQualified" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_23794bfc-203d-42a4-8d25-664e157c4908NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_23794bfc-203d-42a4-8d25-664e157c4908NotDimensionallyQualified" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LossesOnDisposalsOfInvestments_7a0df93e-dba1-40e3-9eff-60a72c984ba7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LossesOnDisposalsOfInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LossesOnDisposalsOfInvestments_7a0df93e-dba1-40e3-9eff-60a72c984ba7NotDimensionallyQualified" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_GainLossOnInvestmentsInNotesFromAssociates_1f38350e-fe89-4e17-b943-213e36b7bf81NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_GainLossOnInvestmentsInNotesFromAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_GainLossOnInvestmentsInNotesFromAssociates_1f38350e-fe89-4e17-b943-213e36b7bf81NotDimensionallyQualified" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherGainsLosses_0458ad5d-074d-4ba0-aca9-de145b89ba11NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherGainsLosses_0458ad5d-074d-4ba0-aca9-de145b89ba11NotDimensionallyQualified" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_7704d228-d63b-450d-8df8-824f1f34bc14NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherOperatingIncomeExpense_7704d228-d63b-450d-8df8-824f1f34bc14NotDimensionallyQualified" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_60ed6c84-e5e8-43b7-ba56-63e7e5b872e2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FinanceIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceIncome_60ed6c84-e5e8-43b7-ba56-63e7e5b872e2NotDimensionallyQualified" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_ca76c0b3-b29a-47c6-ab39-6aa6d44f7932NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FinanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceCosts_ca76c0b3-b29a-47c6-ab39-6aa6d44f7932NotDimensionallyQualified" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities_256fb2bc-e0d1-4d30-8864-484922bef944NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities_256fb2bc-e0d1-4d30-8864-484922bef944NotDimensionallyQualified" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NoncashInterestExpenseRoyaltyLiability_f264b9b2-b783-4451-aa34-32973a7dba67NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NoncashInterestExpenseRoyaltyLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_NoncashInterestExpenseRoyaltyLiability_f264b9b2-b783-4451-aa34-32973a7dba67NotDimensionallyQualified" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_6a5ee847-403b-4166-b143-ecf4df0ed580NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceIncomeCost_6a5ee847-403b-4166-b143-ecf4df0ed580NotDimensionallyQualified" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_2db797ba-ab2b-4eee-8dd9-349675183d26NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_2db797ba-ab2b-4eee-8dd9-349675183d26NotDimensionallyQualified" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_5eb9cebc-5ffa-4bf4-9462-5d2ddef2a4f4NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_5eb9cebc-5ffa-4bf4-9462-5d2ddef2a4f4NotDimensionallyQualified" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLoss_c758eca8-dd16-4584-93a2-6a06b9978476NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ImpairmentLossRecognisedInProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLoss_c758eca8-dd16-4584-93a2-6a06b9978476NotDimensionallyQualified" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_9e869af4-8c74-4a6e-a686-c59fda3bc166NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_9e869af4-8c74-4a6e-a686-c59fda3bc166NotDimensionallyQualified" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_2b1212e0-9705-458b-a6b2-fa0082cce04eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_2b1212e0-9705-458b-a6b2-fa0082cce04eNotDimensionallyQualified" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_ce925d57-dbb1-4fdc-9a9d-77fe60cfad82NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLoss_ce925d57-dbb1-4fdc-9a9d-77fe60cfad82NotDimensionallyQualified" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_115b564e-eeb0-46d8-a55e-67dd63670bddNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_115b564e-eeb0-46d8-a55e-67dd63670bddNotDimensionallyQualified" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments_06a9cc79-6365-4411-8b6f-7ec9becb3743NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments_06a9cc79-6365-4411-8b6f-7ec9becb3743NotDimensionallyQualified" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_c385e140-fd16-4405-9d4d-30e5c1b9bcfaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_c385e140-fd16-4405-9d4d-30e5c1b9bcfaNotDimensionallyQualified" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_3f0e5640-adf2-4f83-ad3a-5a556a0a0c4dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncome_3f0e5640-adf2-4f83-ad3a-5a556a0a0c4dNotDimensionallyQualified" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_30dfc993-c824-4239-a18c-bd1706dc9744NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_30dfc993-c824-4239-a18c-bd1706dc9744NotDimensionallyQualified" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_fdcf7c69-4729-49ac-8917-75034d708160NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_fdcf7c69-4729-49ac-8917-75034d708160NotDimensionallyQualified" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_96d0bbba-468b-49c3-8e4d-fd8710485b29NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_96d0bbba-468b-49c3-8e4d-fd8710485b29NotDimensionallyQualified" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_cf986ce5-98da-4459-8be9-a14df699d006NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_cf986ce5-98da-4459-8be9-a14df699d006NotDimensionallyQualified" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BasicEarningsLossPerShare_4ac3afb3-5a06-4ddb-abca-4343cf81f0b7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_BasicEarningsLossPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_BasicEarningsLossPerShare_4ac3afb3-5a06-4ddb-abca-4343cf81f0b7NotDimensionallyQualified" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DilutedEarningsLossPerShare_fd0aaf66-89fb-49ca-8e2e-03da5df2f990NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DilutedEarningsLossPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DilutedEarningsLossPerShare_fd0aaf66-89fb-49ca-8e2e-03da5df2f990NotDimensionallyQualified" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_2baea140-c8e7-4171-b4ac-642b3f426e6cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_2baea140-c8e7-4171-b4ac-642b3f426e6cNotDimensionallyQualified" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_08c3d735-f232-4e06-b691-a34d93388710NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RightofuseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RightofuseAssets_08c3d735-f232-4e06-b691-a34d93388710NotDimensionallyQualified" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_c863cd64-c53e-48a9-b380-fc04d4261715NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_c863cd64-c53e-48a9-b380-fc04d4261715NotDimensionallyQualified" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss_fbcddcbf-a608-478a-a4a1-0d857c9eec33NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss_fbcddcbf-a608-478a-a4a1-0d857c9eec33NotDimensionallyQualified" xlink:type="arc" order="36"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentsInAssociates_a12210e3-a87c-4b8a-9d6a-3e73bd8dfa42NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InvestmentsInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InvestmentsInAssociates_a12210e3-a87c-4b8a-9d6a-3e73bd8dfa42NotDimensionallyQualified" xlink:type="arc" order="37"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentReceivablesDueFromAssociates_bb947bec-b862-4eb5-ade6-82229ddda214NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentReceivablesDueFromAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentReceivablesDueFromAssociates_bb947bec-b862-4eb5-ade6-82229ddda214NotDimensionallyQualified" xlink:type="arc" order="38"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinanceLeaseReceivables_6a3b6bfc-0cc6-47e6-bd4e-f6096bb994d7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentFinanceLeaseReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinanceLeaseReceivables_6a3b6bfc-0cc6-47e6-bd4e-f6096bb994d7NotDimensionallyQualified" xlink:type="arc" order="39"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_ff6b61df-e525-44b4-a5dd-379b60fe4a20NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_ff6b61df-e525-44b4-a5dd-379b60fe4a20NotDimensionallyQualified" xlink:type="arc" order="40"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_2bfe0356-5b84-4a8a-89ee-0c82b1c55955NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentAssets_2bfe0356-5b84-4a8a-89ee-0c82b1c55955NotDimensionallyQualified" xlink:type="arc" order="41"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_ecfecb07-ec5b-4f52-b075-a1ae6c4587e6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_ecfecb07-ec5b-4f52-b075-a1ae6c4587e6NotDimensionallyQualified" xlink:type="arc" order="42"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_e41f780d-583e-431c-90ea-58e48999153cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_e41f780d-583e-431c-90ea-58e48999153cNotDimensionallyQualified" xlink:type="arc" order="43"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPrepaidExpenses_566b200c-ab90-42be-b1e7-12928cb979d2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentPrepaidExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentPrepaidExpenses_566b200c-ab90-42be-b1e7-12928cb979d2NotDimensionallyQualified" xlink:type="arc" order="44"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinanceLeaseReceivables_6adc661d-2e55-43f9-8f09-5dffc4d21ecfNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentFinanceLeaseReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentFinanceLeaseReceivables_6adc661d-2e55-43f9-8f09-5dffc4d21ecfNotDimensionallyQualified" xlink:type="arc" order="45"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RestrictedCashAndCashEquivalents_31f6104e-9e03-4ab3-b118-25d4bf49855bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RestrictedCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RestrictedCashAndCashEquivalents_31f6104e-9e03-4ab3-b118-25d4bf49855bNotDimensionallyQualified" xlink:type="arc" order="46"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ShortTermInvestments_6bb83ebf-7806-4cda-8f10-8bb7a0c377a5NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ShortTermInvestments_6bb83ebf-7806-4cda-8f10-8bb7a0c377a5NotDimensionallyQualified" xlink:type="arc" order="47"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_7cbb8124-7df6-4eb1-8563-94316d257511NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashAndCashEquivalents_7cbb8124-7df6-4eb1-8563-94316d257511NotDimensionallyQualified" xlink:type="arc" order="48"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_17ad6b6c-84c7-4849-a7ab-af2c2de08e63NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentAssets_17ad6b6c-84c7-4849-a7ab-af2c2de08e63NotDimensionallyQualified" xlink:type="arc" order="49"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_96158115-e358-485f-b515-aa29a149c084NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Assets_96158115-e358-485f-b515-aa29a149c084NotDimensionallyQualified" xlink:type="arc" order="50"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_b001b9d2-deef-4926-8254-b49967a34a57NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IssuedCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IssuedCapital_b001b9d2-deef-4926-8254-b49967a34a57NotDimensionallyQualified" xlink:type="arc" order="51"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_702268f9-b8a4-4f63-a0a5-d083cef0f068NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_SharePremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_SharePremium_702268f9-b8a4-4f63-a0a5-d083cef0f068NotDimensionallyQualified" xlink:type="arc" order="52"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasuryShares_a9ff8aff-526b-4617-8dde-f67fb64b33e1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TreasuryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TreasuryShares_a9ff8aff-526b-4617-8dde-f67fb64b33e1NotDimensionallyQualified" xlink:type="arc" order="53"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MergerReserve_27df0155-24c5-4151-a501-7a2d4185f941NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_MergerReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_MergerReserve_27df0155-24c5-4151-a501-7a2d4185f941NotDimensionallyQualified" xlink:type="arc" order="54"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_088cc738-4340-4a99-9e87-850e12d5c0a2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_088cc738-4340-4a99-9e87-850e12d5c0a2NotDimensionallyQualified" xlink:type="arc" order="55"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_73e4281c-8cac-40d2-83d1-d79114b22bdaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherReserves_73e4281c-8cac-40d2-83d1-d79114b22bdaNotDimensionallyQualified" xlink:type="arc" order="56"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_49445871-8d9a-4ef4-b00a-9cdf2b47c139NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RetainedEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RetainedEarnings_49445871-8d9a-4ef4-b00a-9cdf2b47c139NotDimensionallyQualified" xlink:type="arc" order="57"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_698c1a17-6192-4f5b-be9b-0c5c0f6928d8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_698c1a17-6192-4f5b-be9b-0c5c0f6928d8NotDimensionallyQualified" xlink:type="arc" order="58"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_bcf62856-1703-4c6d-b106-50867b5ee143NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncontrollingInterests_bcf62856-1703-4c6d-b106-50867b5ee143NotDimensionallyQualified" xlink:type="arc" order="59"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_1846a638-7d0d-48ac-b216-48a151c612b9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Equity_1846a638-7d0d-48ac-b216-48a151c612b9NotDimensionallyQualified" xlink:type="arc" order="60"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NonCurrentLiabilitiesRoyaltyLiabilities_59f215ea-e93e-443a-b05c-249e5a67e7fcNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NonCurrentLiabilitiesRoyaltyLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_NonCurrentLiabilitiesRoyaltyLiabilities_59f215ea-e93e-443a-b05c-249e5a67e7fcNotDimensionallyQualified" xlink:type="arc" order="61"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_c964689a-fb01-4dba-9f1a-32156d2cd5f9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_c964689a-fb01-4dba-9f1a-32156d2cd5f9NotDimensionallyQualified" xlink:type="arc" order="62"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLeaseLiabilities_7a3b9960-8eb3-421b-a2ce-d535a59f1856NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentLeaseLiabilities_7a3b9960-8eb3-421b-a2ce-d535a59f1856NotDimensionallyQualified" xlink:type="arc" order="63"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LongtermBorrowings_51fe0138-ee2d-4491-88ee-d058be64c2b2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LongtermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LongtermBorrowings_51fe0138-ee2d-4491-88ee-d058be64c2b2NotDimensionallyQualified" xlink:type="arc" order="64"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NoncurrentLiabilitiesFromShareBasedPaymentTransactions_2775685d-2678-4695-a682-f7d92b3f9cfcNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NoncurrentLiabilitiesFromShareBasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_NoncurrentLiabilitiesFromShareBasedPaymentTransactions_2775685d-2678-4695-a682-f7d92b3f9cfcNotDimensionallyQualified" xlink:type="arc" order="65"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_80bfc7be-3fe4-47ec-9b1e-8adff32317ebNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentLiabilities_80bfc7be-3fe4-47ec-9b1e-8adff32317ebNotDimensionallyQualified" xlink:type="arc" order="66"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_522d84da-46e7-4cf1-bbf8-7012873766f4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentContractLiabilities_522d84da-46e7-4cf1-bbf8-7012873766f4NotDimensionallyQualified" xlink:type="arc" order="67"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLeaseLiabilities_1dfd702e-60e8-4ba6-94bd-4fb764254fdfNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentLeaseLiabilities_1dfd702e-60e8-4ba6-94bd-4fb764254fdfNotDimensionallyQualified" xlink:type="arc" order="68"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_b2d1d23c-5451-4c4e-9704-b3edbefc126bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_b2d1d23c-5451-4c4e-9704-b3edbefc126bNotDimensionallyQualified" xlink:type="arc" order="69"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NotesAndDebenturesIssued_376d9d3b-a3f5-41d6-9a3f-43e829ddf216NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NotesAndDebenturesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NotesAndDebenturesIssued_376d9d3b-a3f5-41d6-9a3f-43e829ddf216NotDimensionallyQualified" xlink:type="arc" order="70"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_0100f53d-f974-4632-b898-b2f3784f74acNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentDerivativeFinancialLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_0100f53d-f974-4632-b898-b2f3784f74acNotDimensionallyQualified" xlink:type="arc" order="71"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PreferredShareLiability_507977c2-410e-4120-b5ec-71c1467da63aNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PreferredShareLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PreferredShareLiability_507977c2-410e-4120-b5ec-71c1467da63aNotDimensionallyQualified" xlink:type="arc" order="72"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_9d6904aa-6184-44a7-9b56-277da6e29a44NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentPortionOfLongtermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_9d6904aa-6184-44a7-9b56-277da6e29a44NotDimensionallyQualified" xlink:type="arc" order="73"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_eedc90c1-7d6c-4da3-b736-278ffcf7c92bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentLiabilities_eedc90c1-7d6c-4da3-b736-278ffcf7c92bNotDimensionallyQualified" xlink:type="arc" order="74"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_5aa6f57f-329d-4cda-8624-2ae6c9147fdbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Liabilities_5aa6f57f-329d-4cda-8624-2ae6c9147fdbNotDimensionallyQualified" xlink:type="arc" order="75"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_5b009e88-ac6e-42e8-81b8-55dbdef6adddNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAndLiabilities_5b009e88-ac6e-42e8-81b8-55dbdef6adddNotDimensionallyQualified" xlink:type="arc" order="76"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_918c5cd2-8248-46c9-ad5d-d54635e63092NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_918c5cd2-8248-46c9-ad5d-d54635e63092NotDimensionallyQualified" xlink:type="arc" order="77"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_ab29e336-451f-45c4-a459-e76b8e656e77NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_ab29e336-451f-45c4-a459-e76b8e656e77NotDimensionallyQualified" xlink:type="arc" order="78"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_d12b8791-cf5d-4e3f-96f2-10014f21021bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForFairValueGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_d12b8791-cf5d-4e3f-96f2-10014f21021bNotDimensionallyQualified" xlink:type="arc" order="79"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_f6c01805-ef31-469c-9d31-37149758aac3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_f6c01805-ef31-469c-9d31-37149758aac3NotDimensionallyQualified" xlink:type="arc" order="80"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates_46e3cafd-56ee-45ca-8e6c-f1f55530d96aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates_46e3cafd-56ee-45ca-8e6c-f1f55530d96aNotDimensionallyQualified" xlink:type="arc" order="81"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForGainsLossesOnChangeInFairValueOfNoteReceivableDueFromAssociates_591cd524-3ef0-49c1-a98a-ba97072b80eaNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_AdjustmentsForGainsLossesOnChangeInFairValueOfNoteReceivableDueFromAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_AdjustmentsForGainsLossesOnChangeInFairValueOfNoteReceivableDueFromAssociates_591cd524-3ef0-49c1-a98a-ba97072b80eaNotDimensionallyQualified" xlink:type="arc" order="82"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_75fb340a-8490-44ff-9447-2463b17e3f63NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_75fb340a-8490-44ff-9447-2463b17e3f63NotDimensionallyQualified" xlink:type="arc" order="83"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_eb725ac5-207c-47b5-bf29-06bd3b34b69bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_eb725ac5-207c-47b5-bf29-06bd3b34b69bNotDimensionallyQualified" xlink:type="arc" order="84"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_7a9654f9-6030-4e17-9261-115b890234f0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_7a9654f9-6030-4e17-9261-115b890234f0NotDimensionallyQualified" xlink:type="arc" order="85"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_1ed05e5d-99cc-4a34-89f5-7d76b43aa900NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncomeTaxExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_1ed05e5d-99cc-4a34-89f5-7d76b43aa900NotDimensionallyQualified" xlink:type="arc" order="86"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceIncomeCost_3d3f9172-b7ee-4c8a-900d-28a3ab4cd587NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForFinanceIncomeCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForFinanceIncomeCost_3d3f9172-b7ee-4c8a-900d-28a3ab4cd587NotDimensionallyQualified" xlink:type="arc" order="87"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_d600d395-424e-42aa-b6c7-ff6a31c7fc3cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_d600d395-424e-42aa-b6c7-ff6a31c7fc3cNotDimensionallyQualified" xlink:type="arc" order="88"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets_a2276a9f-af48-41ca-9fb7-c62089df47adNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets_a2276a9f-af48-41ca-9fb7-c62089df47adNotDimensionallyQualified" xlink:type="arc" order="89"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_8ad0229e-488f-48c4-9880-2c1da551c699NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_8ad0229e-488f-48c4-9880-2c1da551c699NotDimensionallyQualified" xlink:type="arc" order="90"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_df78b154-c275-4d9a-89ee-586ee3574630NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_df78b154-c275-4d9a-89ee-586ee3574630NotDimensionallyQualified" xlink:type="arc" order="91"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_f7a8ace3-a3e5-4651-90fb-83c8c26dfb34NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_f7a8ace3-a3e5-4651-90fb-83c8c26dfb34NotDimensionallyQualified" xlink:type="arc" order="92"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_f30006af-8918-4d96-ad25-ee3baa02a290NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_f30006af-8918-4d96-ad25-ee3baa02a290NotDimensionallyQualified" xlink:type="arc" order="93"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_9a6641de-def6-4e41-8dc3-2d4c8f14a587NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_9a6641de-def6-4e41-8dc3-2d4c8f14a587NotDimensionallyQualified" xlink:type="arc" order="94"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_fec66f18-0e85-4a88-9b82-3bd135e37c0eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_fec66f18-0e85-4a88-9b82-3bd135e37c0eNotDimensionallyQualified" xlink:type="arc" order="95"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_864c2c0b-a4ce-4215-b2b1-e35ae058c5d7NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_864c2c0b-a4ce-4215-b2b1-e35ae058c5d7NotDimensionallyQualified" xlink:type="arc" order="96"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_b8cd89c1-16cf-4338-bab6-668ecc6b26f1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_b8cd89c1-16cf-4338-bab6-668ecc6b26f1NotDimensionallyQualified" xlink:type="arc" order="97"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_4fe3614a-1ae1-4626-84ce-8ed1c7948109NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_4fe3614a-1ae1-4626-84ce-8ed1c7948109NotDimensionallyQualified" xlink:type="arc" order="98"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_d24d6943-5f3a-4ad3-ad20-d0f79c2b97e8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_d24d6943-5f3a-4ad3-ad20-d0f79c2b97e8NotDimensionallyQualified" xlink:type="arc" order="99"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfInterestsInAssociates_ed9eba2b-3d67-4a4c-b14c-625353186528NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfInterestsInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfInterestsInAssociates_ed9eba2b-3d67-4a4c-b14c-625353186528NotDimensionallyQualified" xlink:type="arc" order="100"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_f3d017ae-e10a-41b4-967c-0c4b01b6bb4dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_f3d017ae-e10a-41b4-967c-0c4b01b6bb4dNotDimensionallyQualified" xlink:type="arc" order="101"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_cc64f965-15d4-47bf-ab71-264647b303f3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_cc64f965-15d4-47bf-ab71-264647b303f3NotDimensionallyQualified" xlink:type="arc" order="102"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_311bafcd-157e-4f89-8dfb-a8297415ac1bNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_311bafcd-157e-4f89-8dfb-a8297415ac1bNotDimensionallyQualified" xlink:type="arc" order="103"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_2fbf6edf-c0fb-4cd8-b922-240b1142b1e4NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_2fbf6edf-c0fb-4cd8-b922-240b1142b1e4NotDimensionallyQualified" xlink:type="arc" order="104"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchasesOfConvertibleNote_78d8cef5-726a-4616-9d95-a57dac7bb56fNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PurchasesOfConvertibleNote"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PurchasesOfConvertibleNote_78d8cef5-726a-4616-9d95-a57dac7bb56fNotDimensionallyQualified" xlink:type="arc" order="105"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashInDeconsolidatedSubsidiary_71d5d0d6-1a4e-4fdf-83e1-723c1b457646NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_CashInDeconsolidatedSubsidiary"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_CashInDeconsolidatedSubsidiary_71d5d0d6-1a4e-4fdf-83e1-723c1b457646NotDimensionallyQualified" xlink:type="arc" order="106"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_540646a8-e28a-45b6-b6a1-c8128f7a6e80NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_540646a8-e28a-45b6-b6a1-c8128f7a6e80NotDimensionallyQualified" xlink:type="arc" order="107"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_c7efac4c-e079-49c3-a4c0-187c96a3921fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_c7efac4c-e079-49c3-a4c0-187c96a3921fNotDimensionallyQualified" xlink:type="arc" order="108"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ReceiptOfPaymentOfSublease_e01bb183-09c5-496f-920d-34c62cf2e2d2NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ReceiptOfPaymentOfSublease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ReceiptOfPaymentOfSublease_e01bb183-09c5-496f-920d-34c62cf2e2d2NotDimensionallyQualified" xlink:type="arc" order="109"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_d5c20834-a544-4536-bd06-693d267bf453NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_d5c20834-a544-4536-bd06-693d267bf453NotDimensionallyQualified" xlink:type="arc" order="110"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromSaleOfFutureRoyalties_56035190-5de7-4d10-adda-0c79bade1531NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ProceedsFromSaleOfFutureRoyalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ProceedsFromSaleOfFutureRoyalties_56035190-5de7-4d10-adda-0c79bade1531NotDimensionallyQualified" xlink:type="arc" order="111"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfPreferenceShares_ca818bd3-978e-4a2e-9bb0-0514a1246a7fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromIssueOfPreferenceShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromIssueOfPreferenceShares_ca818bd3-978e-4a2e-9bb0-0514a1246a7fNotDimensionallyQualified" xlink:type="arc" order="112"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_88c45096-19b5-44ab-86ff-21cf64227e53NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_88c45096-19b5-44ab-86ff-21cf64227e53NotDimensionallyQualified" xlink:type="arc" order="113"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_8a65f021-d8b1-4b73-b68d-2c49ee8b3345NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_8a65f021-d8b1-4b73-b68d-2c49ee8b3345NotDimensionallyQualified" xlink:type="arc" order="114"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromExerciseOfOptions_fb9b2bdb-9ea1-4f60-bdae-001cf1b591baNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProceedsFromExerciseOfOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromExerciseOfOptions_fb9b2bdb-9ea1-4f60-bdae-001cf1b591baNotDimensionallyQualified" xlink:type="arc" order="115"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_SettlementOfRestrictedStockUnits_4ede898b-9a89-42c0-9ba4-5322a6e050d1NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_SettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_SettlementOfRestrictedStockUnits_4ede898b-9a89-42c0-9ba4-5322a6e050d1NotDimensionallyQualified" xlink:type="arc" order="116"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_VestingOfRestrictedStockUnits_3abc6dd3-92e5-47c7-8bcd-31dba209f5f9NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_VestingOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_VestingOfRestrictedStockUnits_3abc6dd3-92e5-47c7-8bcd-31dba209f5f9NotDimensionallyQualified" xlink:type="arc" order="117"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_31fe6bb5-66c7-4af7-a05b-24614c139095NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ProceedsFromIssueOfSharesToNonControllingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_31fe6bb5-66c7-4af7-a05b-24614c139095NotDimensionallyQualified" xlink:type="arc" order="118"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToPurchaseTreasuryStock_74ef2e9d-58dd-409d-860d-e96965276e6fNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PaymentToPurchaseTreasuryStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PaymentToPurchaseTreasuryStock_74ef2e9d-58dd-409d-860d-e96965276e6fNotDimensionallyQualified" xlink:type="arc" order="119"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_8167b42e-9e58-4f5b-8a46-dc723c82e169NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_8167b42e-9e58-4f5b-8a46-dc723c82e169NotDimensionallyQualified" xlink:type="arc" order="120"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_1190fe9d-ba77-459e-ae47-66c43fa26907NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_1190fe9d-ba77-459e-ae47-66c43fa26907NotDimensionallyQualified" xlink:type="arc" order="121"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_d7fa645d-5e05-4ac8-95ce-2a1c970bf959NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_d7fa645d-5e05-4ac8-95ce-2a1c970bf959NotDimensionallyQualified" xlink:type="arc" order="122"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_f967e89f-b484-4133-87ef-821df46d27ddNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_f967e89f-b484-4133-87ef-821df46d27ddNotDimensionallyQualified" xlink:type="arc" order="123"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchaseOfIntangibleAssetsButNotYetPaid_a33c6fd0-b0f9-48e3-b291-1647486e0d23NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PurchaseOfIntangibleAssetsButNotYetPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PurchaseOfIntangibleAssetsButNotYetPaid_a33c6fd0-b0f9-48e3-b291-1647486e0d23NotDimensionallyQualified" xlink:type="arc" order="124"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_SettlementOfRestrictedStockUnitsThroughIssuanceOfEquity_244c6fdc-e9dd-44f1-80e6-bbf4c46ef1ceNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_SettlementOfRestrictedStockUnitsThroughIssuanceOfEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_SettlementOfRestrictedStockUnitsThroughIssuanceOfEquity_244c6fdc-e9dd-44f1-80e6-bbf4c46ef1ceNotDimensionallyQualified" xlink:type="arc" order="125"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_b724f49f-e8c5-4013-8bc0-3058b5f746efNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_b724f49f-e8c5-4013-8bc0-3058b5f746efNotDimensionallyQualified" xlink:type="arc" order="126"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_41f20632-ebb2-431c-b857-ba1f2fa623f6NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_41f20632-ebb2-431c-b857-ba1f2fa623f6NotDimensionallyQualified" xlink:type="arc" order="127"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_dbc17303-2649-46a1-aba9-4b5784bf561fNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_dbc17303-2649-46a1-aba9-4b5784bf561fNotDimensionallyQualified" xlink:type="arc" order="128"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_a2d55508-7d9d-46dc-ba4d-9166d7f6f2fcNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfMaterialAccountingPolicyInformationExplanatory_a2d55508-7d9d-46dc-ba4d-9166d7f6f2fcNotDimensionallyQualified" xlink:type="arc" order="129"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_cc8c158f-14ac-452f-a2c3-8ddec730f3deNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_cc8c158f-14ac-452f-a2c3-8ddec730f3deNotDimensionallyQualified" xlink:type="arc" order="130"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfUltimateParentOfGroup_115fa032-caba-47f4-bd5a-34c4cac30c59NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NameOfUltimateParentOfGroup"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfUltimateParentOfGroup_115fa032-caba-47f4-bd5a-34c4cac30c59NotDimensionallyQualified" xlink:type="arc" order="131"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LegalFormOfEntity_c31276d5-73e4-4301-a437-6695b59a1a3dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_LegalFormOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LegalFormOfEntity_c31276d5-73e4-4301-a437-6695b59a1a3dNotDimensionallyQualified" xlink:type="arc" order="132"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CountryOfIncorporation_10956d89-e31b-40c3-be4f-587b0d8ddc19NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CountryOfIncorporation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CountryOfIncorporation_10956d89-e31b-40c3-be4f-587b0d8ddc19NotDimensionallyQualified" xlink:type="arc" order="133"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DomicileOfEntity_ae6af28d-08ad-4064-a033-fae74d2036f8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DomicileOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DomicileOfEntity_ae6af28d-08ad-4064-a033-fae74d2036f8NotDimensionallyQualified" xlink:type="arc" order="134"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_8388ef6e-8afd-4912-9ad6-a1e2588de7c2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AddressOfRegisteredOfficeOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_8388ef6e-8afd-4912-9ad6-a1e2588de7c2NotDimensionallyQualified" xlink:type="arc" order="135"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_2e022700-b889-4d11-95a6-a626252df22dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_2e022700-b889-4d11-95a6-a626252df22dNotDimensionallyQualified" xlink:type="arc" order="136"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfParentEntity_d9de822e-e844-4296-b87a-1b78cd1b547cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NameOfParentEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfParentEntity_d9de822e-e844-4296-b87a-1b78cd1b547cNotDimensionallyQualified" xlink:type="arc" order="137"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PrincipalPlaceOfBusiness_d42877f9-8e93-4e9f-ae66-e6f85002d784NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_PrincipalPlaceOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PrincipalPlaceOfBusiness_d42877f9-8e93-4e9f-ae66-e6f85002d784NotDimensionallyQualified" xlink:type="arc" order="138"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_fdee08b5-b062-47da-98f0-3b52dc447d86NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_fdee08b5-b062-47da-98f0-3b52dc447d86NotDimensionallyQualified" xlink:type="arc" order="139"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfIFRSCompliance_d7eab8d9-85da-4c3a-adbb-e49877d21034NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_StatementOfIFRSCompliance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_StatementOfIFRSCompliance_d7eab8d9-85da-4c3a-adbb-e49877d21034NotDimensionallyQualified" xlink:type="arc" order="140"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExplanationOfMeasurementBasesUsedInPreparingFinancialStatements_d82dc66f-3af4-4cfb-a6fc-1ca567297c65NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ExplanationOfMeasurementBasesUsedInPreparingFinancialStatements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ExplanationOfMeasurementBasesUsedInPreparingFinancialStatements_d82dc66f-3af4-4cfb-a6fc-1ca567297c65NotDimensionallyQualified" xlink:type="arc" order="141"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_f7e37281-6d1c-4281-83dd-de2f60166811NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_f7e37281-6d1c-4281-83dd-de2f60166811NotDimensionallyQualified" xlink:type="arc" order="142"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGoingConcernExplanatory_c82846c7-0e91-4d29-a859-78f35521860fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfGoingConcernExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGoingConcernExplanatory_c82846c7-0e91-4d29-a859-78f35521860fNotDimensionallyQualified" xlink:type="arc" order="143"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_42c31504-7bad-419d-aa9f-20dd5a70f0f1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfBasisOfConsolidationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_42c31504-7bad-419d-aa9f-20dd5a70f0f1NotDimensionallyQualified" xlink:type="arc" order="144"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_ee99b0c2-30fa-4b9c-bbc9-568f0eb7c3fdNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_ee99b0c2-30fa-4b9c-bbc9-568f0eb7c3fdNotDimensionallyQualified" xlink:type="arc" order="145"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory_8427ae2e-5807-44f0-983c-0c80a2d2fce4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTransactionsWithNoncontrollingInterestsExplanatory_8427ae2e-5807-44f0-983c-0c80a2d2fce4NotDimensionallyQualified" xlink:type="arc" order="146"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_86a58a26-1581-4693-8629-11c10ecbce57NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_86a58a26-1581-4693-8629-11c10ecbce57NotDimensionallyQualified" xlink:type="arc" order="147"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory_e4a87ee6-e088-4bc4-abe6-111629a25721NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInvestmentsAccountedForUsingEquityMethodExplanatory_e4a87ee6-e088-4bc4-abe6-111629a25721NotDimensionallyQualified" xlink:type="arc" order="148"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodExplanatory_0086204c-dc4e-46e8-80ec-c819f258b90dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethodExplanatory_0086204c-dc4e-46e8-80ec-c819f258b90dNotDimensionallyQualified" xlink:type="arc" order="149"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_4e652f6c-87b3-4c6d-aad0-ada93f653cfdNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_4e652f6c-87b3-4c6d-aad0-ada93f653cfdNotDimensionallyQualified" xlink:type="arc" order="150"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_146d0f42-0253-4470-aa39-976f904fdea2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_146d0f42-0253-4470-aa39-976f904fdea2NotDimensionallyQualified" xlink:type="arc" order="151"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_b87d31c4-90e9-4371-9cd4-337bfe757b93NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory_b87d31c4-90e9-4371-9cd4-337bfe757b93NotDimensionallyQualified" xlink:type="arc" order="152"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory_cb2cdb6a-8a1a-4d31-9669-523473be099cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory_cb2cdb6a-8a1a-4d31-9669-523473be099cNotDimensionallyQualified" xlink:type="arc" order="153"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_6c105850-0087-4b34-b039-618553291c07NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_6c105850-0087-4b34-b039-618553291c07NotDimensionallyQualified" xlink:type="arc" order="154"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_0f62241e-6411-44c3-bd39-cc863f2f4293NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_0f62241e-6411-44c3-bd39-cc863f2f4293NotDimensionallyQualified" xlink:type="arc" order="155"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory_35e8fc60-1e2d-43ba-9f93-39e6bd935345NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRevenueFromContractsWithCustomersExplanatory_35e8fc60-1e2d-43ba-9f93-39e6bd935345NotDimensionallyQualified" xlink:type="arc" order="156"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants_e4bc98c0-5c07-48ae-a432-728d3175a87dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants_e4bc98c0-5c07-48ae-a432-728d3175a87dNotDimensionallyQualified" xlink:type="arc" order="157"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory_436c1a11-1011-415f-a9ef-85d12a9fa237NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory_436c1a11-1011-415f-a9ef-85d12a9fa237NotDimensionallyQualified" xlink:type="arc" order="158"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_b8b4a959-8b48-48c5-922d-555347b7bb9aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_b8b4a959-8b48-48c5-922d-555347b7bb9aNotDimensionallyQualified" xlink:type="arc" order="159"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory_cd297007-ca68-4265-8df5-83ac3513d3c1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory_cd297007-ca68-4265-8df5-83ac3513d3c1NotDimensionallyQualified" xlink:type="arc" order="160"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_557711d5-3c08-4c52-8c1a-6ef39f1140b6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfTreasurySharesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_557711d5-3c08-4c52-8c1a-6ef39f1140b6NotDimensionallyQualified" xlink:type="arc" order="161"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTreasurySharesExplanatory_4822450c-b67f-4352-8e81-011cd7dfe265NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForTreasurySharesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTreasurySharesExplanatory_4822450c-b67f-4352-8e81-011cd7dfe265NotDimensionallyQualified" xlink:type="arc" order="162"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_7aa66505-389a-4b35-877d-e84bb8692c65NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_7aa66505-389a-4b35-877d-e84bb8692c65NotDimensionallyQualified" xlink:type="arc" order="163"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDepreciationAndAmortisationExpenseExplanatory_7717f949-8fd8-4a1f-bb7f-0df4392f6726NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfDepreciationAndAmortisationExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDepreciationAndAmortisationExpenseExplanatory_7717f949-8fd8-4a1f-bb7f-0df4392f6726NotDimensionallyQualified" xlink:type="arc" order="164"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory_175eb1cd-69d6-43f6-8651-0eea7859006bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForDepreciationExpenseExplanatory_175eb1cd-69d6-43f6-8651-0eea7859006bNotDimensionallyQualified" xlink:type="arc" order="165"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_04157204-eedd-40cf-8f9a-950d78edbb88NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_04157204-eedd-40cf-8f9a-950d78edbb88NotDimensionallyQualified" xlink:type="arc" order="166"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_09208ee7-83d4-42e8-98b6-8eda64ea223cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_09208ee7-83d4-42e8-98b6-8eda64ea223cNotDimensionallyQualified" xlink:type="arc" order="167"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_0b523719-4c14-416b-9b96-676f389ea90fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfImpairmentOfAssetsExplanatory_0b523719-4c14-416b-9b96-676f389ea90fNotDimensionallyQualified" xlink:type="arc" order="168"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_ba0ab117-1411-4430-a5d4-6a392b6a3ad9NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_ba0ab117-1411-4430-a5d4-6a392b6a3ad9NotDimensionallyQualified" xlink:type="arc" order="169"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEmployeeBenefitsExplanatory_755c7f06-3f94-4634-8c3e-26b58f59d8e0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfEmployeeBenefitsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEmployeeBenefitsExplanatory_755c7f06-3f94-4634-8c3e-26b58f59d8e0NotDimensionallyQualified" xlink:type="arc" order="170"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_46b25c29-86c3-48d5-b816-657fab95d283NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_46b25c29-86c3-48d5-b816-657fab95d283NotDimensionallyQualified" xlink:type="arc" order="171"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory_9fbc1b43-a315-41ab-b819-09c2b9858acbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory_9fbc1b43-a315-41ab-b819-09c2b9858acbNotDimensionallyQualified" xlink:type="arc" order="172"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfResearchAndDevelopmentExpenseExplanatory_acdcf00a-597b-4ded-ad88-6e2ef04ebbd3NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfResearchAndDevelopmentExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfResearchAndDevelopmentExpenseExplanatory_acdcf00a-597b-4ded-ad88-6e2ef04ebbd3NotDimensionallyQualified" xlink:type="arc" order="173"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_3fc7c04f-7f5a-4be4-95cc-024eae153077NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_3fc7c04f-7f5a-4be4-95cc-024eae153077NotDimensionallyQualified" xlink:type="arc" order="174"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory_b6d490ac-9060-415a-be5f-fcf3fc56beb4NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory_b6d490ac-9060-415a-be5f-fcf3fc56beb4NotDimensionallyQualified" xlink:type="arc" order="175"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory_289d04d0-7ba0-4579-bc88-99238a8dbeaaNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory_289d04d0-7ba0-4579-bc88-99238a8dbeaaNotDimensionallyQualified" xlink:type="arc" order="176"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceIncomeExplanatory_f26f6a5b-9be3-4149-9019-3185c96b08e0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinanceIncomeExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceIncomeExplanatory_f26f6a5b-9be3-4149-9019-3185c96b08e0NotDimensionallyQualified" xlink:type="arc" order="177"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceCostExplanatory_2c5b659c-0d23-4621-9c41-bca2c976bc61NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinanceCostExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceCostExplanatory_2c5b659c-0d23-4621-9c41-bca2c976bc61NotDimensionallyQualified" xlink:type="arc" order="178"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceCostsExplanatory_4bfb9638-551f-4c9e-821f-d9fdc19c2dbdNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinanceCostsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceCostsExplanatory_4bfb9638-551f-4c9e-821f-d9fdc19c2dbdNotDimensionallyQualified" xlink:type="arc" order="179"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_c3864586-72a7-4e59-b583-9b12bde963deNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_c3864586-72a7-4e59-b583-9b12bde963deNotDimensionallyQualified" xlink:type="arc" order="180"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfDeferredTaxesExplanatory_1cc927c8-26c9-42fe-941b-4a8f88e2ed41NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfDeferredTaxesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfDeferredTaxesExplanatory_1cc927c8-26c9-42fe-941b-4a8f88e2ed41NotDimensionallyQualified" xlink:type="arc" order="181"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_336ddfe8-c109-4981-bfca-1436244d0fc6NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_336ddfe8-c109-4981-bfca-1436244d0fc6NotDimensionallyQualified" xlink:type="arc" order="182"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory_b35597f8-9025-4fa9-a168-09ba0f1cbc99NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory_b35597f8-9025-4fa9-a168-09ba0f1cbc99NotDimensionallyQualified" xlink:type="arc" order="183"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations_8b7f3bd7-51a4-4fd5-a3a7-8715951f9434NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations_8b7f3bd7-51a4-4fd5-a3a7-8715951f9434NotDimensionallyQualified" xlink:type="arc" order="184"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRevenueExplanatory_9bacd9fa-e86d-49fd-849e-481bc0d00857NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfRevenueExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRevenueExplanatory_9bacd9fa-e86d-49fd-849e-481bc0d00857NotDimensionallyQualified" xlink:type="arc" order="185"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_98778ed0-bcfa-495b-90da-7e6908d36865NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_98778ed0-bcfa-495b-90da-7e6908d36865NotDimensionallyQualified" xlink:type="arc" order="186"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_70a6d4df-d772-4beb-80f3-9ac4152d12c2NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_70a6d4df-d772-4beb-80f3-9ac4152d12c2NotDimensionallyQualified" xlink:type="arc" order="187"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialInstrumentsDesignatedAtFairValueThroughProfitOrLossExplanatory_b643cad9-2ac5-4ac5-a664-46a1ddad334aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinancialInstrumentsDesignatedAtFairValueThroughProfitOrLossExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialInstrumentsDesignatedAtFairValueThroughProfitOrLossExplanatory_b643cad9-2ac5-4ac5-a664-46a1ddad334aNotDimensionallyQualified" xlink:type="arc" order="188"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_4cbdc308-eb43-4656-a036-c1c97ae73610NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_4cbdc308-eb43-4656-a036-c1c97ae73610NotDimensionallyQualified" xlink:type="arc" order="189"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfExpensesExplanatory_d3a63834-412a-41cd-a5f4-70a0593f9297NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfExpensesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfExpensesExplanatory_d3a63834-412a-41cd-a5f4-70a0593f9297NotDimensionallyQualified" xlink:type="arc" order="190"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGeneralAndAdministrativeExpenseExplanatory_70797555-924a-48c5-8bbe-b36f3c749992NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfGeneralAndAdministrativeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGeneralAndAdministrativeExpenseExplanatory_70797555-924a-48c5-8bbe-b36f3c749992NotDimensionallyQualified" xlink:type="arc" order="191"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_ec9d0ef4-d6c5-488c-b3ba-aaf20be72f51NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_ec9d0ef4-d6c5-488c-b3ba-aaf20be72f51NotDimensionallyQualified" xlink:type="arc" order="192"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_9db9e89a-a7a6-4910-9505-029bdb336461NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_9db9e89a-a7a6-4910-9505-029bdb336461NotDimensionallyQualified" xlink:type="arc" order="193"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEarningsPerShareExplanatory_d611f24e-2ed8-4b0e-b1ef-0def7f396aa0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfEarningsPerShareExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEarningsPerShareExplanatory_d611f24e-2ed8-4b0e-b1ef-0def7f396aa0NotDimensionallyQualified" xlink:type="arc" order="194"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_e2c631cc-d52e-4768-9b4e-e9142431b678NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_e2c631cc-d52e-4768-9b4e-e9142431b678NotDimensionallyQualified" xlink:type="arc" order="195"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIntangibleAssetsExplanatory_d9fc5523-b556-42e3-8152-64c5c15a730aNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfIntangibleAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIntangibleAssetsExplanatory_d9fc5523-b556-42e3-8152-64c5c15a730aNotDimensionallyQualified" xlink:type="arc" order="196"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherAssetsExplanatory_c248315f-3ebe-4630-9e4a-f9d548fe3b7cNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfOtherAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherAssetsExplanatory_c248315f-3ebe-4630-9e4a-f9d548fe3b7cNotDimensionallyQualified" xlink:type="arc" order="197"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_df8f0198-4005-4f27-8a52-24f6a75656dbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_df8f0198-4005-4f27-8a52-24f6a75656dbNotDimensionallyQualified" xlink:type="arc" order="198"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIssuedCapitalExplanatory_49a5a2bb-7fc9-4cab-9a1f-7a18f87f7f0bNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfIssuedCapitalExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIssuedCapitalExplanatory_49a5a2bb-7fc9-4cab-9a1f-7a18f87f7f0bNotDimensionallyQualified" xlink:type="arc" order="199"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInterestsInSubsidiariesExplanatory_ff068b19-dfe5-433a-a47f-c7212b0382e8NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfInterestsInSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInterestsInSubsidiariesExplanatory_ff068b19-dfe5-433a-a47f-c7212b0382e8NotDimensionallyQualified" xlink:type="arc" order="200"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialLiabilitiesExplanatory_a877358e-4f0c-4176-8343-d10fc6715a84NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinancialLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialLiabilitiesExplanatory_a877358e-4f0c-4176-8343-d10fc6715a84NotDimensionallyQualified" xlink:type="arc" order="201"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialInstrumentsExplanatory_927964df-7b76-442e-b86a-f7bd0c45f885NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialInstrumentsExplanatory_927964df-7b76-442e-b86a-f7bd0c45f885NotDimensionallyQualified" xlink:type="arc" order="202"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_510cc152-0ecf-4c78-832c-56d607d17a03NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_510cc152-0ecf-4c78-832c-56d607d17a03NotDimensionallyQualified" xlink:type="arc" order="203"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_e42f0aeb-cc9c-44f9-9e85-5ff85e1cc0acNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFairValueOfFinancialInstrumentsExplanatory_e42f0aeb-cc9c-44f9-9e85-5ff85e1cc0acNotDimensionallyQualified" xlink:type="arc" order="204"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFairValueMeasurementExplanatory_eb70357b-d42f-45e3-ad86-7548f66219e5NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFairValueMeasurementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFairValueMeasurementExplanatory_eb70357b-d42f-45e3-ad86-7548f66219e5NotDimensionallyQualified" xlink:type="arc" order="205"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_00630525-6362-4884-b83d-e750b1490a8dNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_00630525-6362-4884-b83d-e750b1490a8dNotDimensionallyQualified" xlink:type="arc" order="206"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_265e66b2-96f8-4c7c-9ac1-53b5f3073012NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_265e66b2-96f8-4c7c-9ac1-53b5f3073012NotDimensionallyQualified" xlink:type="arc" order="207"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory_1b295ea2-b8c6-4b2c-b48e-3905e3a18ffbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory_1b295ea2-b8c6-4b2c-b48e-3905e3a18ffbNotDimensionallyQualified" xlink:type="arc" order="208"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_be3f09f7-773c-46e0-a3f6-27036db9d80eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfBorrowingsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_be3f09f7-773c-46e0-a3f6-27036db9d80eNotDimensionallyQualified" xlink:type="arc" order="209"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfLeasesExplanatory_05675358-7031-4b15-a922-0972fbcfd5fbNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfLeasesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfLeasesExplanatory_05675358-7031-4b15-a922-0972fbcfd5fbNotDimensionallyQualified" xlink:type="arc" order="210"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_21a1a92b-9486-4ab2-ae68-aad94913389fNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfFinancialRiskManagementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_21a1a92b-9486-4ab2-ae68-aad94913389fNotDimensionallyQualified" xlink:type="arc" order="211"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCreditRiskExplanatory_f93aa4f7-50b1-405b-8fad-524c38ca6960NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfCreditRiskExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCreditRiskExplanatory_f93aa4f7-50b1-405b-8fad-524c38ca6960NotDimensionallyQualified" xlink:type="arc" order="212"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfLiquidityRiskExplanatory_8a2ceb39-4c39-480c-ae4e-6e49c9b3aa40NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfLiquidityRiskExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfLiquidityRiskExplanatory_8a2ceb39-4c39-480c-ae4e-6e49c9b3aa40NotDimensionallyQualified" xlink:type="arc" order="213"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_d7f5a7a5-b1e0-4e28-9e8a-62e6f3f5e8e1NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_d7f5a7a5-b1e0-4e28-9e8a-62e6f3f5e8e1NotDimensionallyQualified" xlink:type="arc" order="214"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfContingentLiabilitiesExplanatory_0f810600-c07b-4dc4-bf69-4c2a12962bafNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfContingentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfContingentLiabilitiesExplanatory_0f810600-c07b-4dc4-bf69-4c2a12962bafNotDimensionallyQualified" xlink:type="arc" order="215"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCommitmentsExplanatory_0c274ba5-7e7b-4aa4-a80a-cc92bcf773e0NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfCommitmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCommitmentsExplanatory_0c274ba5-7e7b-4aa4-a80a-cc92bcf773e0NotDimensionallyQualified" xlink:type="arc" order="216"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory_56f2702a-a83b-4370-977b-b42dc1c2c86eNotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory_56f2702a-a83b-4370-977b-b42dc1c2c86eNotDimensionallyQualified" xlink:type="arc" order="217"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_ae20700e-c2dc-48e5-8051-d89b78494148NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_ae20700e-c2dc-48e5-8051-d89b78494148NotDimensionallyQualified" xlink:type="arc" order="218"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_2847da60-1543-4489-ae23-0ae750476b01NotDimensionallyQualified" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_2847da60-1543-4489-ae23-0ae750476b01NotDimensionallyQualified" xlink:type="arc" order="219"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://ptv.com/role/Anchoring" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#Anchoring"/>
  <link:definitionLink xlink:role="http://ptv.com/role/Anchoring" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForGainsLossesOnChangeInFairValueOfNoteReceivableDueFromAssociates_3f9b0b83-378b-426d-a1bc-4236feadda47" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_AdjustmentsForGainsLossesOnChangeInFairValueOfNoteReceivableDueFromAssociates"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AcquisitionsThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AcquisitionsThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AcquisitionsThroughBusinessCombinationsIntangibleAssetsOtherThanGoodwill" xlink:to="loc_ptv_AdjustmentsForGainsLossesOnChangeInFairValueOfNoteReceivableDueFromAssociates_3f9b0b83-378b-426d-a1bc-4236feadda47" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_948a767a-2245-47fc-98ec-9c5fc21d75f9" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForReconcileProfitLoss" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForReconcileProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AdjustmentsForReconcileProfitLoss" xlink:to="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_948a767a-2245-47fc-98ec-9c5fc21d75f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashInDeconsolidatedSubsidiary_2dac5cad-e124-4065-bb73-370c2b8d6ba8" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_CashInDeconsolidatedSubsidiary"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_ptv_CashInDeconsolidatedSubsidiary_2dac5cad-e124-4065-bb73-370c2b8d6ba8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_92b5cedd-8204-4533-8d95-29eab279ed68" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToOtherPartiesClassifiedAsInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToOtherPartiesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToOtherPartiesClassifiedAsInvestingActivities" xlink:to="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_92b5cedd-8204-4533-8d95-29eab279ed68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_61c4a529-d24f-4a05-9f4b-4f5ab0a0f99f" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughConversionOfConvertibleInstruments" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughConversionOfConvertibleInstruments"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughConversionOfConvertibleInstruments" xlink:to="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_61c4a529-d24f-4a05-9f4b-4f5ab0a0f99f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_DecreaseInNonControllingFromExpirationOfShareOptionsInSubsidiary_b3dc6946-ce52-4216-9641-f62cec7d0cf1" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_DecreaseInNonControllingFromExpirationOfShareOptionsInSubsidiary"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:to="loc_ptv_DecreaseInNonControllingFromExpirationOfShareOptionsInSubsidiary_b3dc6946-ce52-4216-9641-f62cec7d0cf1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_GainLossOnInvestmentsInNotesFromAssociates_09c64889-c403-4b9c-871f-859c989cd156" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_GainLossOnInvestmentsInNotesFromAssociates"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherOperatingIncomeExpense" xlink:to="loc_ptv_GainLossOnInvestmentsInNotesFromAssociates_09c64889-c403-4b9c-871f-859c989cd156" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_3a5c68b8-734d-4564-b843-f0316b83e7c4" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ProfitLossBeforeTax" xlink:to="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_3a5c68b8-734d-4564-b843-f0316b83e7c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_43e0e639-07a7-43e7-8b4b-81d7e46d1c6c" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AmountOfReclassificationsOrChangesInPresentation" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AmountOfReclassificationsOrChangesInPresentation"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AmountOfReclassificationsOrChangesInPresentation" xlink:to="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_43e0e639-07a7-43e7-8b4b-81d7e46d1c6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_d66bbe89-3a83-4ccd-8df4-087dda1f0e21" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ChangesInEquity" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ChangesInEquity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_d66bbe89-3a83-4ccd-8df4-087dda1f0e21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_82bb7e1c-acb6-4516-822e-053724b63f0f" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_82bb7e1c-acb6-4516-822e-053724b63f0f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_804552b4-b7d5-4d00-be45-f2499d2247b5" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_804552b4-b7d5-4d00-be45-f2499d2247b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_fb6b8261-43bb-4bbd-9c4d-7debb6190313" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_fb6b8261-43bb-4bbd-9c4d-7debb6190313" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_5a75ab14-1424-450d-b4b1-67c47724b40e" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ChangesInPropertyPlantAndEquipment" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_ChangesInPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInPropertyPlantAndEquipment" xlink:to="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_5a75ab14-1424-450d-b4b1-67c47724b40e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NonCurrentLiabilitiesRoyaltyLiabilities_f1588e15-d3b4-4e92-a95a-397230af5fab" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NonCurrentLiabilitiesRoyaltyLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_NoncurrentLiabilities" xlink:to="loc_ptv_NonCurrentLiabilitiesRoyaltyLiabilities_f1588e15-d3b4-4e92-a95a-397230af5fab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NoncashInterestExpenseRoyaltyLiability_5cd4b197-3337-454a-8d46-5ac108f1e756" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NoncashInterestExpenseRoyaltyLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RoyaltyExpense" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_RoyaltyExpense"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_RoyaltyExpense" xlink:to="loc_ptv_NoncashInterestExpenseRoyaltyLiability_5cd4b197-3337-454a-8d46-5ac108f1e756" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NoncurrentLiabilitiesFromShareBasedPaymentTransactions_ed235027-4e72-4a28-8e38-afecb5b4b4b5" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NoncurrentLiabilitiesFromShareBasedPaymentTransactions"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AccrualsClassifiedAsNoncurrent" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_AccrualsClassifiedAsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AccrualsClassifiedAsNoncurrent" xlink:to="loc_ptv_NoncurrentLiabilitiesFromShareBasedPaymentTransactions_ed235027-4e72-4a28-8e38-afecb5b4b4b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NumberOfOrdinarySharesIssuedToSettleShareBasedPaymentAwards_f59ac607-425c-4a8c-bf07-878dbb16c739" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NumberOfOrdinarySharesIssuedToSettleShareBasedPaymentAwards"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued" xlink:to="loc_ptv_NumberOfOrdinarySharesIssuedToSettleShareBasedPaymentAwards_f59ac607-425c-4a8c-bf07-878dbb16c739" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NumberOfTreasurySharesPurchased_6b593b29-ba74-426e-adcc-2c4a7cc76cae" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_NumberOfTreasurySharesPurchased"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInNumberOfSharesOutstanding" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInNumberOfSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInNumberOfSharesOutstanding" xlink:to="loc_ptv_NumberOfTreasurySharesPurchased_6b593b29-ba74-426e-adcc-2c4a7cc76cae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_OtherAssetsAndLiabilitiesNet_8243430e-835c-4bc2-887c-75e33827729a" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_OtherAssetsAndLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetAssetsLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_NetAssetsLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_NetAssetsLiabilities" xlink:to="loc_ptv_OtherAssetsAndLiabilitiesNet_8243430e-835c-4bc2-887c-75e33827729a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_7d762411-4a46-435d-b296-5871df9d9b21" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OutflowsOfCashFromInvestingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OutflowsOfCashFromInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OutflowsOfCashFromInvestingActivities" xlink:to="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_7d762411-4a46-435d-b296-5871df9d9b21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToPurchaseTreasuryStock_5164878e-050f-402a-b376-95c7bf0c6723" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PaymentToPurchaseTreasuryStock"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_ptv_PaymentToPurchaseTreasuryStock_5164878e-050f-402a-b376-95c7bf0c6723" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PreferredShareLiability_d2f741ef-2101-449e-9bf2-6279809406b7" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PreferredShareLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CurrentLiabilities" xlink:to="loc_ptv_PreferredShareLiability_d2f741ef-2101-449e-9bf2-6279809406b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_7a74874a-03dd-4206-848f-ddf3d1bf7acf" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ProceedsFromIssueOfSharesToNonControllingInterests"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughFinancingCashFlowsLiabilitiesArisingFromFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseThroughFinancingCashFlowsLiabilitiesArisingFromFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughFinancingCashFlowsLiabilitiesArisingFromFinancingActivities" xlink:to="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_7a74874a-03dd-4206-848f-ddf3d1bf7acf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromSaleOfFutureRoyalties_4153463e-f277-4dfe-8964-2f3bc3d1f2f4" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ProceedsFromSaleOfFutureRoyalties"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities" xlink:to="loc_ptv_ProceedsFromSaleOfFutureRoyalties_4153463e-f277-4dfe-8964-2f3bc3d1f2f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchaseOfIntangibleAssetsButNotYetPaid_aadf9e46-d87b-4802-bd28-40608d73da86" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PurchaseOfIntangibleAssetsButNotYetPaid"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInIntangibleAssetsAndGoodwill" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_IncreaseDecreaseInIntangibleAssetsAndGoodwill"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInIntangibleAssetsAndGoodwill" xlink:to="loc_ptv_PurchaseOfIntangibleAssetsButNotYetPaid_aadf9e46-d87b-4802-bd28-40608d73da86" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_66788d2d-e64c-4cd9-a092-3ab573f73ad5" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInPropertyPlantAndEquipment" xlink:to="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_66788d2d-e64c-4cd9-a092-3ab573f73ad5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchasesOfConvertibleNote_ba076ef2-e58b-435e-ac3c-0b6b2af7d72b" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_PurchasesOfConvertibleNote"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_ptv_PurchasesOfConvertibleNote_ba076ef2-e58b-435e-ac3c-0b6b2af7d72b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ReceiptOfPaymentOfSublease_75e75345-594a-466c-9135-91a598473b48" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ReceiptOfPaymentOfSublease"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_ptv_ReceiptOfPaymentOfSublease_75e75345-594a-466c-9135-91a598473b48" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_SettlementOfRestrictedStockUnits_4584ad84-de24-4e87-995d-ecc0fac3ddac" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_SettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_ptv_SettlementOfRestrictedStockUnits_4584ad84-de24-4e87-995d-ecc0fac3ddac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_SettlementOfRestrictedStockUnitsThroughIssuanceOfEquity_2b256419-e70d-4d20-82eb-288e7e8daf05" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_SettlementOfRestrictedStockUnitsThroughIssuanceOfEquity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_ptv_SettlementOfRestrictedStockUnitsThroughIssuanceOfEquity_2b256419-e70d-4d20-82eb-288e7e8daf05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ShortTermInvestments_f868a4ea-73b7-4960-8d25-527d4496238d" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_ShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets" xlink:href="https://xbrl.ifrs.org/taxonomy/2022-03-24/full_ifrs/full_ifrs-cor_2022-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CurrentAssets" xlink:to="loc_ptv_ShortTermInvestments_f868a4ea-73b7-4960-8d25-527d4496238d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_VestingOfRestrictedStockUnits_3a39d7b9-960e-4e8b-b6ee-f90cdbad90f2" xlink:href="213800LVPDNO2Z9T9I39-2023-12-31.xsd#ptv_VestingOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_ptv_VestingOfRestrictedStockUnits_3a39d7b9-960e-4e8b-b6ee-f90cdbad90f2" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
