<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:4458b191-0dc9-42c2-93ff-6ada3002925f,g:7367a1bf-fc5b-44f5-95ca-c4b4c96f738f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:arcroleRef arcroleURI="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd#wider-narrower"/>
  <link:roleRef roleURI="http://ptv.com/role/StatementofchangesinequityStatement" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#StatementofchangesinequityStatement"/>
  <link:definitionLink xlink:role="http://ptv.com/role/StatementofchangesinequityStatement" xlink:type="extended" id="i512a1b7712e449409f16bdef94256916_StatementofchangesinequityStatement">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfChangesInEquityLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NumberOfSharesIssued_9da1462d-6f71-428a-a354-b6eb6d42c62a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NumberOfSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_NumberOfSharesIssued_9da1462d-6f71-428a-a354-b6eb6d42c62a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_e3b30a0b-fd39-4c64-8644-b1fb9889215f" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_Equity_e3b30a0b-fd39-4c64-8644-b1fb9889215f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_b522f0b2-297c-42da-a487-f9e26b56bc9b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_ProfitLoss_b522f0b2-297c-42da-a487-f9e26b56bc9b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_8d357921-8cd7-44b4-bfbf-4aea44f57753" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_8d357921-8cd7-44b4-bfbf-4aea44f57753" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_85b9b4e5-8c24-4d02-b09a-2534c054dc74" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_ComprehensiveIncome_85b9b4e5-8c24-4d02-b09a-2534c054dc74" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughChangeInEquityOfSubsidiaries_c6a2d449-2507-4136-97fe-4cfde08d16fd" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughChangeInEquityOfSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughChangeInEquityOfSubsidiaries_c6a2d449-2507-4136-97fe-4cfde08d16fd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseInNumberOfOrdinarySharesIssuedThroughExerciseOfShareBasedAwards_26d903eb-b6a8-4c93-9788-6855ba295203" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseInNumberOfOrdinarySharesIssuedThroughExerciseOfShareBasedAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseDecreaseInNumberOfOrdinarySharesIssuedThroughExerciseOfShareBasedAwards_26d903eb-b6a8-4c93-9788-6855ba295203" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughExerciseOfOptions_b2946079-c700-4c2b-9ee0-70186d18a3d0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughExerciseOfOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughExerciseOfOptions_b2946079-c700-4c2b-9ee0-70186d18a3d0" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_d970d7a5-b6b8-47fb-be2c-66d0574ef38a" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_d970d7a5-b6b8-47fb-be2c-66d0574ef38a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NumberOfTreasurySharesPurchased_ad934bb8-65f0-4e6f-8778-a906172f4f0c" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_NumberOfTreasurySharesPurchased"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_NumberOfTreasurySharesPurchased_ad934bb8-65f0-4e6f-8778-a906172f4f0c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfTreasuryShares_1a844301-1a2e-4ae6-8951-5bc01d3ae5b7" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfTreasuryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_PurchaseOfTreasuryShares_1a844301-1a2e-4ae6-8951-5bc01d3ae5b7" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions_d108fcb6-7954-4ae6-adc4-100b75c77b0a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions_d108fcb6-7954-4ae6-adc4-100b75c77b0a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseInNumberOfOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_84b44d46-ac7a-40f3-b920-38e93a996c50" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseInNumberOfOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseInNumberOfOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_84b44d46-ac7a-40f3-b920-38e93a996c50" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_6b7c681b-b156-4d8c-ba70-35c9126c19bc" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_6b7c681b-b156-4d8c-ba70-35c9126c19bc" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_54a8f492-fde2-4cbe-a503-933876e8fe6e" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_54a8f492-fde2-4cbe-a503-933876e8fe6e" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_9f202556-6807-4fc2-b179-de1a6348fa3a" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughTransfersAndOtherChangesEquity_9f202556-6807-4fc2-b179-de1a6348fa3a" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactions_568c8e9a-1552-40a5-aa7f-250883c56f29" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_DecreaseIncreaseThroughTaxOnSharebasedPaymentTransactions_568c8e9a-1552-40a5-aa7f-250883c56f29" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_1d75b496-309e-4bac-9b17-ed9f5745207d" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_1d75b496-309e-4bac-9b17-ed9f5745207d" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_64ca77bb-092a-426a-beda-8584ee0dd6e0" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_64ca77bb-092a-426a-beda-8584ee0dd6e0" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_2943ffc9-5ca2-4a89-ba48-ab7d6b96acaa" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_2943ffc9-5ca2-4a89-ba48-ab7d6b96acaa" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughAcquisitionOfSubsidiary_8d54cb47-e2c4-4259-a582-98dba11130e4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughAcquisitionOfSubsidiary"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughAcquisitionOfSubsidiary_8d54cb47-e2c4-4259-a582-98dba11130e4" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_9117152e-ab18-45d8-9ea2-9ee3826743f0" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughOtherDistributionsToOwners_50ca9233-f9b7-48e0-8c05-d2937d12fef8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughOtherDistributionsToOwners"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_IncreaseDecreaseThroughOtherDistributionsToOwners_50ca9233-f9b7-48e0-8c05-d2937d12fef8" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NumberOfSharesIssued_5fcc7527-2f58-483d-b67c-a59542bf3286" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NumberOfSharesIssued"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_f6a936d3-bc63-4041-a7a2-72c1ae0da979" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfChangesInEquityTable_84b47758-84a5-4359-99f2-d4990a754760" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfChangesInEquityTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ifrs-full_StatementOfChangesInEquityLineItems_5f8e87fc-e99a-4586-9f39-d510d89663b2" xlink:to="loc_ifrs-full_StatementOfChangesInEquityTable_84b47758-84a5-4359-99f2-d4990a754760" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComponentsOfEquityAxis_d5359fbb-10d4-439f-ad10-8c49433743fb" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComponentsOfEquityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ifrs-full_StatementOfChangesInEquityTable_84b47758-84a5-4359-99f2-d4990a754760" xlink:to="loc_ifrs-full_ComponentsOfEquityAxis_d5359fbb-10d4-439f-ad10-8c49433743fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_ComponentsOfEquityAxis_d5359fbb-10d4-439f-ad10-8c49433743fb" xlink:to="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapitalMember_d2fd386f-e829-4245-8ffa-7587175a78d4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_IssuedCapitalMember_d2fd386f-e829-4245-8ffa-7587175a78d4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremiumMember_3b3b1488-1df3-404a-8525-a50075054c9c" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SharePremiumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_SharePremiumMember_3b3b1488-1df3-404a-8525-a50075054c9c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasurySharesMember_9cee45ee-182f-49ef-bf26-eab4cbceab6b" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TreasurySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_TreasurySharesMember_9cee45ee-182f-49ef-bf26-eab4cbceab6b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MergerReserveMember_aeee41d8-d4de-406f-b8b7-cf56c08d80a4" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_MergerReserveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_MergerReserveMember_aeee41d8-d4de-406f-b8b7-cf56c08d80a4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_077218e6-f6f7-4e85-9d32-77e329658755" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslationMember_077218e6-f6f7-4e85-9d32-77e329658755" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReservesMember_ae73a016-ac55-49ad-967d-508958694fd8" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherReservesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_OtherReservesMember_ae73a016-ac55-49ad-967d-508958694fd8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarningsMember_7963d350-ea85-4c9e-981b-862208cf8b4d" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_RetainedEarningsMember_7963d350-ea85-4c9e-981b-862208cf8b4d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_75bcb23b-42df-429e-87da-1f72cc5d3a44" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParentMember_75bcb23b-42df-429e-87da-1f72cc5d3a44" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterestsMember_74efa0bd-868e-42e0-8700-6003d63d04a9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncontrollingInterestsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_EquityMember_e2c120de-c1be-48a7-8550-99951c16258c" xlink:to="loc_ifrs-full_NoncontrollingInterestsMember_74efa0bd-868e-42e0-8700-6003d63d04a9" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://ptv.com/role/StatementofcashflowsindirectmethodParentheticalDetails" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#StatementofcashflowsindirectmethodParentheticalDetails"/>
  <link:definitionLink xlink:role="http://ptv.com/role/StatementofcashflowsindirectmethodParentheticalDetails" xlink:type="extended" id="i63e383756aa44377b995e411f324fd60_StatementofcashflowsindirectmethodParentheticalDetails">
    <link:loc xlink:type="locator" xlink:label="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_StatementOfCashFlowsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_a52875ef-564a-4a16-a612-00e11e4c21ce" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_a52875ef-564a-4a16-a612-00e11e4c21ce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NotesAndDebenturesIssued_6341b174-5b2b-492f-8050-dce631316701" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NotesAndDebenturesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_NotesAndDebenturesIssued_6341b174-5b2b-492f-8050-dce631316701" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapitalPreferenceShares_78b6801e-1080-4875-b3ca-1f5f0f2a59ab" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapitalPreferenceShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_IssuedCapitalPreferenceShares_78b6801e-1080-4875-b3ca-1f5f0f2a59ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_OtherAssetsAndLiabilitiesNet_95ec243f-58c7-4913-995c-60298f26f23f" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_OtherAssetsAndLiabilitiesNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ptv_OtherAssetsAndLiabilitiesNet_95ec243f-58c7-4913-995c-60298f26f23f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_718e4b6f-319a-4f20-b4b1-23db283a3216" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_NoncontrollingInterests_718e4b6f-319a-4f20-b4b1-23db283a3216" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_eba6a899-d0cf-4a03-bf63-2a9286e97c50" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_Equity_eba6a899-d0cf-4a03-bf63-2a9286e97c50" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_5c476d98-2825-4644-9362-5b7e79663975" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_5c476d98-2825-4644-9362-5b7e79663975" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_30c9c824-09eb-4f92-b1a9-ad4b668d4423" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_30c9c824-09eb-4f92-b1a9-ad4b668d4423" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Cash_fb824eaa-14c1-4158-9e27-639c8e32f261" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Cash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ifrs-full_Cash_fb824eaa-14c1-4158-9e27-639c8e32f261" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_StatementOfCashFlowsTable_f5cf13d2-c98f-4b03-957d-1de0d11e799f" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_StatementOfCashFlowsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ptv_StatementOfCashFlowsLineItems_a7510094-e282-4a93-8d13-8fe36c6adcb4" xlink:to="loc_ptv_StatementOfCashFlowsTable_f5cf13d2-c98f-4b03-957d-1de0d11e799f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="scenario"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CounterpartiesAxis_4a9ed32c-9c3e-4914-8f83-f248e76d00b9" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CounterpartiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_ptv_StatementOfCashFlowsTable_f5cf13d2-c98f-4b03-957d-1de0d11e799f" xlink:to="loc_ifrs-full_CounterpartiesAxis_4a9ed32c-9c3e-4914-8f83-f248e76d00b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CounterpartiesMember_1a551d99-8801-40f9-82f9-4ca020cac1ce" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CounterpartiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_ifrs-full_CounterpartiesAxis_4a9ed32c-9c3e-4914-8f83-f248e76d00b9" xlink:to="loc_ifrs-full_CounterpartiesMember_1a551d99-8801-40f9-82f9-4ca020cac1ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_DeconsolidatedFormerSubsidiaryOperatingCompaniesMember_8c951228-640a-4088-a921-4843243ba801" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_DeconsolidatedFormerSubsidiaryOperatingCompaniesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ifrs-full_CounterpartiesMember_1a551d99-8801-40f9-82f9-4ca020cac1ce" xlink:to="loc_ptv_DeconsolidatedFormerSubsidiaryOperatingCompaniesMember_8c951228-640a-4088-a921-4843243ba801" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="simple" xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor.xsd#esef_role-999999"/>
  <link:definitionLink xlink:role="http://www.esma.europa.eu/xbrl/role/cor/esef_role-999999" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor.xsd#esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_ba891530-1dca-4933-9921-08a80f4237e6NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_ba891530-1dca-4933-9921-08a80f4237e6NotDimensionallyQualified" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromGovernmentGrants_967e7439-51d0-4ac1-b368-cf0d39c0d352NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RevenueFromGovernmentGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RevenueFromGovernmentGrants_967e7439-51d0-4ac1-b368-cf0d39c0d352NotDimensionallyQualified" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_495b9174-4081-4618-9d20-52790aee92c8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Revenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Revenue_495b9174-4081-4618-9d20-52790aee92c8NotDimensionallyQualified" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_ef35ae42-80dd-43c7-96d7-861e1ffe3b56NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_ef35ae42-80dd-43c7-96d7-861e1ffe3b56NotDimensionallyQualified" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_9d6f3d46-5868-4044-b2ff-09aeb11116caNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_9d6f3d46-5868-4044-b2ff-09aeb11116caNotDimensionallyQualified" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_c34acbb5-e1e1-4165-a91e-5536602c6b83NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_c34acbb5-e1e1-4165-a91e-5536602c6b83NotDimensionallyQualified" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_a33f6dc6-34a8-447c-af84-7754af36b17fNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_a33f6dc6-34a8-447c-af84-7754af36b17fNotDimensionallyQualified" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_4360e513-c81a-4ce2-89f2-c1c7f88eca96NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_4360e513-c81a-4ce2-89f2-c1c7f88eca96NotDimensionallyQualified" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LossesOnDisposalsOfInvestments_ae511b66-be31-484b-b014-b5f96bb7d843NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LossesOnDisposalsOfInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LossesOnDisposalsOfInvestments_ae511b66-be31-484b-b014-b5f96bb7d843NotDimensionallyQualified" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherGainsLosses_bc8d31b3-336f-4841-bd9d-b54bd5c9e19bNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherGainsLosses_bc8d31b3-336f-4841-bd9d-b54bd5c9e19bNotDimensionallyQualified" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherOperatingIncomeExpense_00aef55f-043c-4308-b521-0afeab5043ddNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherOperatingIncomeExpense_00aef55f-043c-4308-b521-0afeab5043ddNotDimensionallyQualified" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_6a8e7448-2910-4628-8d56-8db1c3d6bad5NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceIncome_6a8e7448-2910-4628-8d56-8db1c3d6bad5NotDimensionallyQualified" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_62e8461d-7579-499e-9819-bc49d6a9ba86NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceCosts_62e8461d-7579-499e-9819-bc49d6a9ba86NotDimensionallyQualified" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities_5b98d325-a0dc-441f-a3d3-8927958fbc0bNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities_5b98d325-a0dc-441f-a3d3-8927958fbc0bNotDimensionallyQualified" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_7f209d93-a666-47cd-b73f-66469bff0725NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_FinanceIncomeCost_7f209d93-a666-47cd-b73f-66469bff0725NotDimensionallyQualified" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_6cb75c4b-59d7-4102-a85a-c7e2340c01d5NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_6cb75c4b-59d7-4102-a85a-c7e2340c01d5NotDimensionallyQualified" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_374fcc22-205f-4987-bb13-d681782316f8NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_374fcc22-205f-4987-bb13-d681782316f8NotDimensionallyQualified" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLoss_2bbd7f4d-8933-4a89-8fbd-60ac4faac1d3NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ImpairmentLossRecognisedInProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLoss_2bbd7f4d-8933-4a89-8fbd-60ac4faac1d3NotDimensionallyQualified" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_81facbbf-c6fe-4095-9cad-5406ecf48502NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_81facbbf-c6fe-4095-9cad-5406ecf48502NotDimensionallyQualified" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_708b2e26-29cd-42b2-a6d4-3e1ef85892f1NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_708b2e26-29cd-42b2-a6d4-3e1ef85892f1NotDimensionallyQualified" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_fa679625-3bc2-4ecd-be0e-e52e59be4131NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLoss_fa679625-3bc2-4ecd-be0e-e52e59be4131NotDimensionallyQualified" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_219123a4-5755-4cdf-a0da-216dc51b730fNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_219123a4-5755-4cdf-a0da-216dc51b730fNotDimensionallyQualified" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments_3e074c5f-43b1-49ab-8237-cd8f83f0fc5dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncomeBeforeTaxGainsLossesFromInvestmentsInEquityInstruments_3e074c5f-43b1-49ab-8237-cd8f83f0fc5dNotDimensionallyQualified" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_b1c0a3da-795d-46a9-8cac-76c1268109d0NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_b1c0a3da-795d-46a9-8cac-76c1268109d0NotDimensionallyQualified" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_6ac87238-85ae-44e4-8388-2df740336820NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncome_6ac87238-85ae-44e4-8388-2df740336820NotDimensionallyQualified" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_5db4f912-067c-4d1c-8448-a1e0b7914de5NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_5db4f912-067c-4d1c-8448-a1e0b7914de5NotDimensionallyQualified" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_2fa2c181-9b71-4666-a781-56377d6fe4ddNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_2fa2c181-9b71-4666-a781-56377d6fe4ddNotDimensionallyQualified" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_c2be4102-2a95-46fe-9687-e1f5f68e3582NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_c2be4102-2a95-46fe-9687-e1f5f68e3582NotDimensionallyQualified" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_e6d669ac-ab0b-4ac3-a3bf-7238b2c05f32NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_e6d669ac-ab0b-4ac3-a3bf-7238b2c05f32NotDimensionallyQualified" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_BasicEarningsLossPerShare_e635ed4d-77c5-4ccf-9b96-cbe7bd895cffNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_BasicEarningsLossPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_BasicEarningsLossPerShare_e635ed4d-77c5-4ccf-9b96-cbe7bd895cffNotDimensionallyQualified" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DilutedEarningsLossPerShare_cf8bc09a-dac6-44b2-be52-fc58759781acNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DilutedEarningsLossPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DilutedEarningsLossPerShare_cf8bc09a-dac6-44b2-be52-fc58759781acNotDimensionallyQualified" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_dbb5525e-7e53-4c8c-8ba4-02fc2d16b2a8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_dbb5525e-7e53-4c8c-8ba4-02fc2d16b2a8NotDimensionallyQualified" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_ba40d552-f01f-4ba2-9432-63ce97b845c9NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RightofuseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RightofuseAssets_ba40d552-f01f-4ba2-9432-63ce97b845c9NotDimensionallyQualified" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_a513bc4e-5d49-41d1-bdce-08a074a443e5NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_a513bc4e-5d49-41d1-bdce-08a074a443e5NotDimensionallyQualified" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss_0335cd76-61ab-4eaf-9905-0e995a1e88ecNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss_0335cd76-61ab-4eaf-9905-0e995a1e88ecNotDimensionallyQualified" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentsInAssociates_ede7908c-859d-4cbc-8dfb-94fe9d79440dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InvestmentsInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InvestmentsInAssociates_ede7908c-859d-4cbc-8dfb-94fe9d79440dNotDimensionallyQualified" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentReceivablesDueFromAssociates_a875acd6-dbcb-4287-9e09-622df2c66355NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentReceivablesDueFromAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentReceivablesDueFromAssociates_a875acd6-dbcb-4287-9e09-622df2c66355NotDimensionallyQualified" xlink:type="arc" order="36"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinanceLeaseReceivables_0c9674dc-01c5-4b3a-af91-25465a1040d0NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentFinanceLeaseReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentFinanceLeaseReceivables_0c9674dc-01c5-4b3a-af91-25465a1040d0NotDimensionallyQualified" xlink:type="arc" order="37"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_c71dd9df-1a57-44f1-baa0-23053840e8ffNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_c71dd9df-1a57-44f1-baa0-23053840e8ffNotDimensionallyQualified" xlink:type="arc" order="38"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_325fc491-b11a-4c47-8134-fab175e633e8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentAssets_325fc491-b11a-4c47-8134-fab175e633e8NotDimensionallyQualified" xlink:type="arc" order="39"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_38a01b44-9ef2-4df1-b3a2-52eac66222eaNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_38a01b44-9ef2-4df1-b3a2-52eac66222eaNotDimensionallyQualified" xlink:type="arc" order="40"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_55149240-d8cf-4fc4-807b-cd5ceb601651NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_55149240-d8cf-4fc4-807b-cd5ceb601651NotDimensionallyQualified" xlink:type="arc" order="41"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPrepaidExpenses_faa647b7-e8da-4c8a-890d-1d0f781a5598NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentPrepaidExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentPrepaidExpenses_faa647b7-e8da-4c8a-890d-1d0f781a5598NotDimensionallyQualified" xlink:type="arc" order="42"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinanceLeaseReceivables_0d3d3565-4e10-4ee7-b64a-8dc5288423b3NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentFinanceLeaseReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentFinanceLeaseReceivables_0d3d3565-4e10-4ee7-b64a-8dc5288423b3NotDimensionallyQualified" xlink:type="arc" order="43"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RestrictedCashAndCashEquivalents_5e8457f2-0089-4773-9f73-8774239c13c2NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RestrictedCashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RestrictedCashAndCashEquivalents_5e8457f2-0089-4773-9f73-8774239c13c2NotDimensionallyQualified" xlink:type="arc" order="44"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentReceivablesDueFromAssociates_345f0943-5370-4976-8888-afa8a044d639NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentReceivablesDueFromAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentReceivablesDueFromAssociates_345f0943-5370-4976-8888-afa8a044d639NotDimensionallyQualified" xlink:type="arc" order="45"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ShortTermInvestments_c1468b28-e525-4838-abcf-5694f8f90802NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ShortTermInvestments_c1468b28-e525-4838-abcf-5694f8f90802NotDimensionallyQualified" xlink:type="arc" order="46"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_640419c9-4bf4-4a8c-9c16-8a5a940427e3NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashAndCashEquivalents_640419c9-4bf4-4a8c-9c16-8a5a940427e3NotDimensionallyQualified" xlink:type="arc" order="47"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_b2d7154f-7fee-458c-9155-7270dc542a14NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentAssets_b2d7154f-7fee-458c-9155-7270dc542a14NotDimensionallyQualified" xlink:type="arc" order="48"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_66016e7f-aec4-4bcf-afec-73deb8b4f866NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Assets_66016e7f-aec4-4bcf-afec-73deb8b4f866NotDimensionallyQualified" xlink:type="arc" order="49"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_b4a11e2e-9dd4-4901-8d9a-3b363640e821NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IssuedCapital_b4a11e2e-9dd4-4901-8d9a-3b363640e821NotDimensionallyQualified" xlink:type="arc" order="50"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_825769b6-8637-404c-a364-7095bfa0135cNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SharePremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_SharePremium_825769b6-8637-404c-a364-7095bfa0135cNotDimensionallyQualified" xlink:type="arc" order="51"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TreasuryShares_7e3dd4c6-37ac-4265-9c90-e457a12b56e7NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TreasuryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TreasuryShares_7e3dd4c6-37ac-4265-9c90-e457a12b56e7NotDimensionallyQualified" xlink:type="arc" order="52"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MergerReserve_c0282e72-6b73-496c-b58e-9f904752d4deNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_MergerReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_MergerReserve_c0282e72-6b73-496c-b58e-9f904752d4deNotDimensionallyQualified" xlink:type="arc" order="53"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_06a03d4d-d355-4c97-ae38-2f9162d3acb0NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_06a03d4d-d355-4c97-ae38-2f9162d3acb0NotDimensionallyQualified" xlink:type="arc" order="54"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_6d41233e-1514-43d4-b46b-4638a27677b2NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherReserves_6d41233e-1514-43d4-b46b-4638a27677b2NotDimensionallyQualified" xlink:type="arc" order="55"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_5ce3ee7c-f2ee-4176-ad94-5c8dfe95767dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RetainedEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_RetainedEarnings_5ce3ee7c-f2ee-4176-ad94-5c8dfe95767dNotDimensionallyQualified" xlink:type="arc" order="56"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_73db36f2-c32a-4270-8bf0-7c0adee0a662NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_73db36f2-c32a-4270-8bf0-7c0adee0a662NotDimensionallyQualified" xlink:type="arc" order="57"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_4f43c8cc-0ca2-4665-aaa8-cf46351d03a5NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncontrollingInterests_4f43c8cc-0ca2-4665-aaa8-cf46351d03a5NotDimensionallyQualified" xlink:type="arc" order="58"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_8c138902-6dda-4048-91ec-a73b2b75cc16NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Equity_8c138902-6dda-4048-91ec-a73b2b75cc16NotDimensionallyQualified" xlink:type="arc" order="59"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_5907104c-dc08-46a5-8c5c-911b9e9455c2NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_5907104c-dc08-46a5-8c5c-911b9e9455c2NotDimensionallyQualified" xlink:type="arc" order="60"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLeaseLiabilities_1b21bf25-95bf-40db-a347-3a7b5139faa6NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentLeaseLiabilities_1b21bf25-95bf-40db-a347-3a7b5139faa6NotDimensionallyQualified" xlink:type="arc" order="61"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LongtermBorrowings_a5135252-f591-45d5-baaf-6f3f8da4385cNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LongtermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LongtermBorrowings_a5135252-f591-45d5-baaf-6f3f8da4385cNotDimensionallyQualified" xlink:type="arc" order="62"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_718b7f35-10ed-4566-a35c-10271d645aa6NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_718b7f35-10ed-4566-a35c-10271d645aa6NotDimensionallyQualified" xlink:type="arc" order="63"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_3f7b9621-ed9c-4337-8095-5d62d63816c0NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NoncurrentLiabilities_3f7b9621-ed9c-4337-8095-5d62d63816c0NotDimensionallyQualified" xlink:type="arc" order="64"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_c18a61c7-0f54-49c1-8431-365555f202faNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentContractLiabilities_c18a61c7-0f54-49c1-8431-365555f202faNotDimensionallyQualified" xlink:type="arc" order="65"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLeaseLiabilities_b663d35d-b6fd-4b57-aa70-0362ef11f4b1NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentLeaseLiabilities_b663d35d-b6fd-4b57-aa70-0362ef11f4b1NotDimensionallyQualified" xlink:type="arc" order="66"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_72badff0-dc62-4b40-8362-1c578a5d959aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_72badff0-dc62-4b40-8362-1c578a5d959aNotDimensionallyQualified" xlink:type="arc" order="67"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NotesAndDebenturesIssued_1240b63d-0e37-4827-b219-0779099bd554NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NotesAndDebenturesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NotesAndDebenturesIssued_1240b63d-0e37-4827-b219-0779099bd554NotDimensionallyQualified" xlink:type="arc" order="68"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_582623c3-f658-4c84-9c89-dfb90c5c3fb1NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentDerivativeFinancialLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_582623c3-f658-4c84-9c89-dfb90c5c3fb1NotDimensionallyQualified" xlink:type="arc" order="69"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PreferredShareLiability_66b28348-fe20-4e56-a852-8f3dd6142f26NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PreferredShareLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PreferredShareLiability_66b28348-fe20-4e56-a852-8f3dd6142f26NotDimensionallyQualified" xlink:type="arc" order="70"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_ff6d6718-5ef8-4e6e-b2a3-d5ff7663c133NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentPortionOfLongtermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_ff6d6718-5ef8-4e6e-b2a3-d5ff7663c133NotDimensionallyQualified" xlink:type="arc" order="71"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_70fdc84e-5e4a-4294-bb92-056fec16d5aeNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CurrentLiabilities_70fdc84e-5e4a-4294-bb92-056fec16d5aeNotDimensionallyQualified" xlink:type="arc" order="72"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_240ae0e3-fe06-4391-87ca-2d7863efe18cNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_Liabilities_240ae0e3-fe06-4391-87ca-2d7863efe18cNotDimensionallyQualified" xlink:type="arc" order="73"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_c5cd16b2-b0c5-4fcf-bfdc-6b6ac3dd46aaNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_EquityAndLiabilities_c5cd16b2-b0c5-4fcf-bfdc-6b6ac3dd46aaNotDimensionallyQualified" xlink:type="arc" order="74"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_8a1b0722-34ff-430f-a5d5-794febb3638eNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_8a1b0722-34ff-430f-a5d5-794febb3638eNotDimensionallyQualified" xlink:type="arc" order="75"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_0ffeeba2-9cf0-482a-a946-48e5db1294f6NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_0ffeeba2-9cf0-482a-a946-48e5db1294f6NotDimensionallyQualified" xlink:type="arc" order="76"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_05556808-0061-48b5-8a80-55c83d910d96NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForFairValueGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_05556808-0061-48b5-8a80-55c83d910d96NotDimensionallyQualified" xlink:type="arc" order="77"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_0cc931ff-1553-4631-a6cb-a1f29058493dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_0cc931ff-1553-4631-a6cb-a1f29058493dNotDimensionallyQualified" xlink:type="arc" order="78"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_4a250d1f-7297-41d8-8301-24cb88cfb50cNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForImpairmentLossReversalOfImpairmentLossRecognisedInProfitOrLoss_4a250d1f-7297-41d8-8301-24cb88cfb50cNotDimensionallyQualified" xlink:type="arc" order="79"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates_8152bd38-6805-4016-89b6-16b95327621dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates_8152bd38-6805-4016-89b6-16b95327621dNotDimensionallyQualified" xlink:type="arc" order="80"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_46a82c81-9c7a-4ece-88ef-73d10891e75dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_46a82c81-9c7a-4ece-88ef-73d10891e75dNotDimensionallyQualified" xlink:type="arc" order="81"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_f3efbdc9-5a5c-4b22-b467-653add6fe058NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_f3efbdc9-5a5c-4b22-b467-653add6fe058NotDimensionallyQualified" xlink:type="arc" order="82"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_f3aab952-8575-4c34-ac57-01bfb8cd6debNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncomeTaxExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_f3aab952-8575-4c34-ac57-01bfb8cd6debNotDimensionallyQualified" xlink:type="arc" order="83"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceIncomeCost_1e9cf495-a52a-4fa5-9ba4-f07abd19c4e0NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForFinanceIncomeCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForFinanceIncomeCost_1e9cf495-a52a-4fa5-9ba4-f07abd19c4e0NotDimensionallyQualified" xlink:type="arc" order="84"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_b9efe70b-5184-419a-83aa-0e073f500d8aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_b9efe70b-5184-419a-83aa-0e073f500d8aNotDimensionallyQualified" xlink:type="arc" order="85"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets_c2079361-a0ed-4a03-8bc0-b1ee6c4bc78eNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets_c2079361-a0ed-4a03-8bc0-b1ee6c4bc78eNotDimensionallyQualified" xlink:type="arc" order="86"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_430d6c7c-857c-431f-9b68-14b727ca26e3NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_430d6c7c-857c-431f-9b68-14b727ca26e3NotDimensionallyQualified" xlink:type="arc" order="87"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_776b6f29-5f35-47c7-a13a-31b082b959cbNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_776b6f29-5f35-47c7-a13a-31b082b959cbNotDimensionallyQualified" xlink:type="arc" order="88"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_a0a83c34-9f52-437f-98d2-b4d9ec35de5aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_a0a83c34-9f52-437f-98d2-b4d9ec35de5aNotDimensionallyQualified" xlink:type="arc" order="89"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_7fec51bf-1638-4897-b447-d5d903a5404cNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_7fec51bf-1638-4897-b447-d5d903a5404cNotDimensionallyQualified" xlink:type="arc" order="90"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_c136099c-6387-4e63-a8da-aaaec4102e0dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_c136099c-6387-4e63-a8da-aaaec4102e0dNotDimensionallyQualified" xlink:type="arc" order="91"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_4a52b6e4-af95-4dd2-819f-86b8e49b9c2fNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_4a52b6e4-af95-4dd2-819f-86b8e49b9c2fNotDimensionallyQualified" xlink:type="arc" order="92"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_a5938a5f-a701-4171-95bb-958ce0240bc3NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_a5938a5f-a701-4171-95bb-958ce0240bc3NotDimensionallyQualified" xlink:type="arc" order="93"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_71baa808-aaad-4660-ac00-0f8fb15d4a21NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_71baa808-aaad-4660-ac00-0f8fb15d4a21NotDimensionallyQualified" xlink:type="arc" order="94"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_5b9b0f33-ba54-49e1-8058-79b8603f5c43NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_5b9b0f33-ba54-49e1-8058-79b8603f5c43NotDimensionallyQualified" xlink:type="arc" order="95"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_a3ac6a12-91e3-41ee-83b8-dca3fb7fa401NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_a3ac6a12-91e3-41ee-83b8-dca3fb7fa401NotDimensionallyQualified" xlink:type="arc" order="96"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfInterestsInAssociates_8ecbb7c2-79e0-4b9f-b5ec-1967e770e805NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfInterestsInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfInterestsInAssociates_8ecbb7c2-79e0-4b9f-b5ec-1967e770e805NotDimensionallyQualified" xlink:type="arc" order="97"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_fe32264b-1d21-4063-9b29-46bea6a29ba3NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_fe32264b-1d21-4063-9b29-46bea6a29ba3NotDimensionallyQualified" xlink:type="arc" order="98"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_67146372-70de-4093-b8a8-c590595306dbNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_67146372-70de-4093-b8a8-c590595306dbNotDimensionallyQualified" xlink:type="arc" order="99"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_d7aea7fd-32d9-4c8d-ab6b-87ef78477370NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_d7aea7fd-32d9-4c8d-ab6b-87ef78477370NotDimensionallyQualified" xlink:type="arc" order="100"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_5be9c290-8087-4fef-83ef-a6a22b379fb4NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_5be9c290-8087-4fef-83ef-a6a22b379fb4NotDimensionallyQualified" xlink:type="arc" order="101"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_40a25a26-5685-4898-8f24-84dc06ca6770NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_40a25a26-5685-4898-8f24-84dc06ca6770NotDimensionallyQualified" xlink:type="arc" order="102"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchasesOfConvertibleNote_36b937e6-d8ea-4e18-8598-eb505951da21NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PurchasesOfConvertibleNote"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PurchasesOfConvertibleNote_36b937e6-d8ea-4e18-8598-eb505951da21NotDimensionallyQualified" xlink:type="arc" order="103"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashInDeconsolidatedSubsidiary_7ba6f44c-e343-4b82-8372-4328e55d193eNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_CashInDeconsolidatedSubsidiary"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_CashInDeconsolidatedSubsidiary_7ba6f44c-e343-4b82-8372-4328e55d193eNotDimensionallyQualified" xlink:type="arc" order="104"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_df64b963-9b27-439d-9db6-cbe51c1923c9NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_df64b963-9b27-439d-9db6-cbe51c1923c9NotDimensionallyQualified" xlink:type="arc" order="105"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_4eae0347-fd66-481c-bacb-3e033bc93e2aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_4eae0347-fd66-481c-bacb-3e033bc93e2aNotDimensionallyQualified" xlink:type="arc" order="106"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ReceiptOfPaymentOfSublease_41c32d2d-246d-4c2c-bf07-24c0d90291faNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ReceiptOfPaymentOfSublease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ReceiptOfPaymentOfSublease_41c32d2d-246d-4c2c-bf07-24c0d90291faNotDimensionallyQualified" xlink:type="arc" order="107"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_66155746-af07-492a-be06-6f85af119f3eNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_66155746-af07-492a-be06-6f85af119f3eNotDimensionallyQualified" xlink:type="arc" order="108"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromCurrentBorrowings_ce8b8e79-e36a-4264-bcad-04bdf43d9814NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromCurrentBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromCurrentBorrowings_ce8b8e79-e36a-4264-bcad-04bdf43d9814NotDimensionallyQualified" xlink:type="arc" order="109"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_9b908c70-de84-4f5b-ae0b-8fb4d7c19b97NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromNoncurrentBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_9b908c70-de84-4f5b-ae0b-8fb4d7c19b97NotDimensionallyQualified" xlink:type="arc" order="110"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfPreferenceShares_d1234ee4-ea84-4b89-8109-f9d1568ef857NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromIssueOfPreferenceShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromIssueOfPreferenceShares_d1234ee4-ea84-4b89-8109-f9d1568ef857NotDimensionallyQualified" xlink:type="arc" order="111"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_fa31cf68-3065-4caa-a0f6-b0e630c56f60NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_fa31cf68-3065-4caa-a0f6-b0e630c56f60NotDimensionallyQualified" xlink:type="arc" order="112"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_d8c5d971-5224-4ee6-939f-13020923b28bNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_d8c5d971-5224-4ee6-939f-13020923b28bNotDimensionallyQualified" xlink:type="arc" order="113"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromExerciseOfOptions_464a794e-d85f-496b-bdce-c9a6812778c8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromExerciseOfOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromExerciseOfOptions_464a794e-d85f-496b-bdce-c9a6812778c8NotDimensionallyQualified" xlink:type="arc" order="114"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_SettlementOfRestrictedStockUnits_881002e6-eedd-400d-8436-bcdeb09f8399NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_SettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_SettlementOfRestrictedStockUnits_881002e6-eedd-400d-8436-bcdeb09f8399NotDimensionallyQualified" xlink:type="arc" order="115"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_VestingOfRestrictedStockUnits_e1d35531-af5d-430e-b190-d08d6daa1d11NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_VestingOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_VestingOfRestrictedStockUnits_e1d35531-af5d-430e-b190-d08d6daa1d11NotDimensionallyQualified" xlink:type="arc" order="116"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_374b9d63-dbc9-4101-b671-d08096d43bb8NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ProceedsFromIssueOfSharesToNonControllingInterests"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_374b9d63-dbc9-4101-b671-d08096d43bb8NotDimensionallyQualified" xlink:type="arc" order="117"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromExerciseOfWarrants_f709b375-a6f2-4e62-a45c-45a81244f142NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromExerciseOfWarrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ProceedsFromExerciseOfWarrants_f709b375-a6f2-4e62-a45c-45a81244f142NotDimensionallyQualified" xlink:type="arc" order="118"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToPurchaseTreasuryStock_8e0f0d17-7125-4f80-a1cb-150f92612762NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PaymentToPurchaseTreasuryStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PaymentToPurchaseTreasuryStock_8e0f0d17-7125-4f80-a1cb-150f92612762NotDimensionallyQualified" xlink:type="arc" order="119"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_d87c2d28-ec69-4211-82bb-5bdac5cd4296NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_d87c2d28-ec69-4211-82bb-5bdac5cd4296NotDimensionallyQualified" xlink:type="arc" order="120"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_8a15a36f-68c4-40fc-9c8f-35308b116b64NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_8a15a36f-68c4-40fc-9c8f-35308b116b64NotDimensionallyQualified" xlink:type="arc" order="121"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_1f077ac1-1b86-4ae6-bc7d-a0595bb3dba7NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_1f077ac1-1b86-4ae6-bc7d-a0595bb3dba7NotDimensionallyQualified" xlink:type="arc" order="122"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_b6d99b28-fb33-459c-a141-b9879e3e8dcfNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges_b6d99b28-fb33-459c-a141-b9879e3e8dcfNotDimensionallyQualified" xlink:type="arc" order="123"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_009a9302-bede-46f2-848a-a8115f030ef0NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_009a9302-bede-46f2-848a-a8115f030ef0NotDimensionallyQualified" xlink:type="arc" order="124"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_c1de74f7-c372-41f8-be02-a1465de4091aNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_c1de74f7-c372-41f8-be02-a1465de4091aNotDimensionallyQualified" xlink:type="arc" order="125"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_ca348405-ceb6-4410-a6bc-efabb1a3ac6bNotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_ca348405-ceb6-4410-a6bc-efabb1a3ac6bNotDimensionallyQualified" xlink:type="arc" order="126"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_c8b2b4ee-15bc-47f9-83a6-ec247917c007NotDimensionallyQualified" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_c8b2b4ee-15bc-47f9-83a6-ec247917c007NotDimensionallyQualified" xlink:type="arc" order="127"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfNotesAndOtherExplanatoryInformationExplanatory_03c3568b-289b-4418-873e-c1c33b8387feNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfNotesAndOtherExplanatoryInformationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfNotesAndOtherExplanatoryInformationExplanatory_03c3568b-289b-4418-873e-c1c33b8387feNotDimensionallyQualified" xlink:type="arc" order="128"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory_9eec065b-810d-4f71-9767-fbdc21d953bfNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory_9eec065b-810d-4f71-9767-fbdc21d953bfNotDimensionallyQualified" xlink:type="arc" order="129"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_28f9f0fe-3aeb-4a80-b0db-c27bced8caa8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfReportingEntityOrOtherMeansOfIdentification_28f9f0fe-3aeb-4a80-b0db-c27bced8caa8NotDimensionallyQualified" xlink:type="arc" order="130"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CountryOfIncorporation_ac7b8273-d779-486a-8673-64cd2de8dc91NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CountryOfIncorporation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_CountryOfIncorporation_ac7b8273-d779-486a-8673-64cd2de8dc91NotDimensionallyQualified" xlink:type="arc" order="131"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DomicileOfEntity_aaecd5b1-692c-4da5-ae3f-eefbe610ce0aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DomicileOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DomicileOfEntity_aaecd5b1-692c-4da5-ae3f-eefbe610ce0aNotDimensionallyQualified" xlink:type="arc" order="132"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_b4a81694-d00a-4ba3-8d2e-761a0380ee22NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfNatureOfEntitysOperationsAndPrincipalActivities_b4a81694-d00a-4ba3-8d2e-761a0380ee22NotDimensionallyQualified" xlink:type="arc" order="133"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfParentEntity_4b07587e-1a0a-49a0-9f5f-785d2205f6e1NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NameOfParentEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfParentEntity_4b07587e-1a0a-49a0-9f5f-785d2205f6e1NotDimensionallyQualified" xlink:type="arc" order="134"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NameOfUltimateParentOfGroup_9a960913-22f1-4b78-ab4b-7821293637a2NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NameOfUltimateParentOfGroup"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_NameOfUltimateParentOfGroup_9a960913-22f1-4b78-ab4b-7821293637a2NotDimensionallyQualified" xlink:type="arc" order="135"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LegalFormOfEntity_273b4bbd-df1d-4296-ae8d-483240177b63NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LegalFormOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_LegalFormOfEntity_273b4bbd-df1d-4296-ae8d-483240177b63NotDimensionallyQualified" xlink:type="arc" order="136"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_ada0e806-2a6e-4999-bb72-20d294c749c3NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AddressOfRegisteredOfficeOfEntity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_AddressOfRegisteredOfficeOfEntity_ada0e806-2a6e-4999-bb72-20d294c749c3NotDimensionallyQualified" xlink:type="arc" order="137"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PrincipalPlaceOfBusiness_8dc52fb7-570f-4cf9-b6c9-06fdd3f54b27NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PrincipalPlaceOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_PrincipalPlaceOfBusiness_8dc52fb7-570f-4cf9-b6c9-06fdd3f54b27NotDimensionallyQualified" xlink:type="arc" order="138"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_96e0e598-01de-428d-9839-a604a2c599b7NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfPreparationOfFinancialStatementsExplanatory_96e0e598-01de-428d-9839-a604a2c599b7NotDimensionallyQualified" xlink:type="arc" order="139"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_StatementOfIFRSCompliance_066595e3-3c78-496d-9868-6d3724f89b24NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfIFRSCompliance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_StatementOfIFRSCompliance_066595e3-3c78-496d-9868-6d3724f89b24NotDimensionallyQualified" xlink:type="arc" order="140"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ExplanationOfMeasurementBasesUsedInPreparingFinancialStatements_bb044a01-d82d-428c-9361-d0fb86093db9NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExplanationOfMeasurementBasesUsedInPreparingFinancialStatements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_ExplanationOfMeasurementBasesUsedInPreparingFinancialStatements_bb044a01-d82d-428c-9361-d0fb86093db9NotDimensionallyQualified" xlink:type="arc" order="141"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_483a852c-efa3-4766-b542-8c6e06603df1NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfAccountingJudgementsAndEstimatesExplanatory_483a852c-efa3-4766-b542-8c6e06603df1NotDimensionallyQualified" xlink:type="arc" order="142"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfGoingConcernExplanatory_e41ed692-0472-4229-8148-68d03a9b5269NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfGoingConcernExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfGoingConcernExplanatory_e41ed692-0472-4229-8148-68d03a9b5269NotDimensionallyQualified" xlink:type="arc" order="143"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_f0dfc838-1034-48f4-9bd5-71d7bd3de3cbNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfBasisOfConsolidationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBasisOfConsolidationExplanatory_f0dfc838-1034-48f4-9bd5-71d7bd3de3cbNotDimensionallyQualified" xlink:type="arc" order="144"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_96fda841-0e44-429e-849f-b5038172294fNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSubsidiariesExplanatory_96fda841-0e44-429e-849f-b5038172294fNotDimensionallyQualified" xlink:type="arc" order="145"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_96979f53-bfcc-4021-a47d-0aa7de3a5911NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates_96979f53-bfcc-4021-a47d-0aa7de3a5911NotDimensionallyQualified" xlink:type="arc" order="146"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_1f450504-b7bd-4b10-97f0-832285e62b9eNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory_1f450504-b7bd-4b10-97f0-832285e62b9eNotDimensionallyQualified" xlink:type="arc" order="147"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_431eaa23-789b-4175-9827-a8976bdc9c2fNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialAssetsExplanatory_431eaa23-789b-4175-9827-a8976bdc9c2fNotDimensionallyQualified" xlink:type="arc" order="148"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_fb4b5629-b1af-4f9c-9b79-afdcce942e79NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialLiabilitiesExplanatory_fb4b5629-b1af-4f9c-9b79-afdcce942e79NotDimensionallyQualified" xlink:type="arc" order="149"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_447fda70-dc14-4ac9-8eb4-10507f57b31dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForRecognitionOfRevenue_447fda70-dc14-4ac9-8eb4-10507f57b31dNotDimensionallyQualified" xlink:type="arc" order="150"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants_a8c9a3a7-7705-4ebb-993f-eca4181b864aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForGovernmentGrants_a8c9a3a7-7705-4ebb-993f-eca4181b864aNotDimensionallyQualified" xlink:type="arc" order="151"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory_6da709d2-d8ba-4894-8ecc-ab321756e573NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFunctionalCurrencyExplanatory_6da709d2-d8ba-4894-8ecc-ab321756e573NotDimensionallyQualified" xlink:type="arc" order="152"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_698b1f02-f00f-416a-b795-407af77ed7edNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory_698b1f02-f00f-416a-b795-407af77ed7edNotDimensionallyQualified" xlink:type="arc" order="153"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForRestrictedCashAndCashEquivalentsExplanatory_2255cfba-8357-4788-9d1e-c0b32b9e3de0NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForRestrictedCashAndCashEquivalentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForRestrictedCashAndCashEquivalentsExplanatory_2255cfba-8357-4788-9d1e-c0b32b9e3de0NotDimensionallyQualified" xlink:type="arc" order="154"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory_262f14e6-123a-4d67-b53f-bf0a0adfcbe8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory_262f14e6-123a-4d67-b53f-bf0a0adfcbe8NotDimensionallyQualified" xlink:type="arc" order="155"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_3d3c9b3d-079a-415e-8c21-afd644adaf0bNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfTreasurySharesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTreasurySharesExplanatory_3d3c9b3d-079a-415e-8c21-afd644adaf0bNotDimensionallyQualified" xlink:type="arc" order="156"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_27c835c2-8b18-4fc7-adef-cd22698079caNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory_27c835c2-8b18-4fc7-adef-cd22698079caNotDimensionallyQualified" xlink:type="arc" order="157"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_8ba4527f-98fa-4d7a-969a-408e8be3cea2NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory_8ba4527f-98fa-4d7a-969a-408e8be3cea2NotDimensionallyQualified" xlink:type="arc" order="158"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_b2751e50-a838-406c-b92f-c1e8b5bf2410NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfNonfinancialAssetsExplanatory_b2751e50-a838-406c-b92f-c1e8b5bf2410NotDimensionallyQualified" xlink:type="arc" order="159"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_695e3fc9-74ce-449a-8bfb-51d70e16c647NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForEmployeeBenefitsExplanatory_695e3fc9-74ce-449a-8bfb-51d70e16c647NotDimensionallyQualified" xlink:type="arc" order="160"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_948e87f2-5aaf-4919-a89c-289149112cbbNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory_948e87f2-5aaf-4919-a89c-289149112cbbNotDimensionallyQualified" xlink:type="arc" order="161"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory_46563982-de7c-4c95-bc10-42f3a924c7a5NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory_46563982-de7c-4c95-bc10-42f3a924c7a5NotDimensionallyQualified" xlink:type="arc" order="162"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_1840d334-5d0a-491d-8b52-4c7341324f92NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForProvisionsExplanatory_1840d334-5d0a-491d-8b52-4c7341324f92NotDimensionallyQualified" xlink:type="arc" order="163"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory_565002a0-9f29-4385-9e7b-fcd0bad79377NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory_565002a0-9f29-4385-9e7b-fcd0bad79377NotDimensionallyQualified" xlink:type="arc" order="164"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory_9f8390d8-1f8e-42a8-ab7a-a6952e6c87c8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinanceIncomeAndCostsExplanatory_9f8390d8-1f8e-42a8-ab7a-a6952e6c87c8NotDimensionallyQualified" xlink:type="arc" order="165"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_28af300c-6606-42bc-a807-35474cbd7095NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory_28af300c-6606-42bc-a807-35474cbd7095NotDimensionallyQualified" xlink:type="arc" order="166"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_44dc11d9-86b4-4bb8-966f-20d657d39cddNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory_44dc11d9-86b4-4bb8-966f-20d657d39cddNotDimensionallyQualified" xlink:type="arc" order="167"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory_4ce3ce8b-e8c6-4139-bd82-1794f63aab29NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory_4ce3ce8b-e8c6-4139-bd82-1794f63aab29NotDimensionallyQualified" xlink:type="arc" order="168"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations_4de7360b-025c-47dd-9fa0-ed1803886adeNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfExpectedImpactOfInitialApplicationOfNewStandardsOrInterpretations_4de7360b-025c-47dd-9fa0-ed1803886adeNotDimensionallyQualified" xlink:type="arc" order="169"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfRevenueExplanatory_7ed62eff-0151-429d-85a4-1770a0cb9f53NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfRevenueExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfRevenueExplanatory_7ed62eff-0151-429d-85a4-1770a0cb9f53NotDimensionallyQualified" xlink:type="arc" order="170"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory_02eebeaa-33df-4894-81d3-1f39f6b29547NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForTradeAndOtherReceivablesExplanatory_02eebeaa-33df-4894-81d3-1f39f6b29547NotDimensionallyQualified" xlink:type="arc" order="171"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_52a081aa-f9cc-4cdb-9e32-c353b5aa8c00NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEntitysReportableSegmentsExplanatory_52a081aa-f9cc-4cdb-9e32-c353b5aa8c00NotDimensionallyQualified" xlink:type="arc" order="172"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_5a188295-c749-49e7-ad85-1104b0c3585dNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_5a188295-c749-49e7-ad85-1104b0c3585dNotDimensionallyQualified" xlink:type="arc" order="173"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_5b2c2755-5a9f-4c4b-bf2e-beca08f9553aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInAssociatesExplanatory_5b2c2755-5a9f-4c4b-bf2e-beca08f9553aNotDimensionallyQualified" xlink:type="arc" order="174"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfExpensesExplanatory_51531297-a577-47fa-aaf6-5246b9483a53NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfExpensesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfExpensesExplanatory_51531297-a577-47fa-aaf6-5246b9483a53NotDimensionallyQualified" xlink:type="arc" order="175"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_b27e80b2-7097-4e13-bd9f-de480f007191NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory_b27e80b2-7097-4e13-bd9f-de480f007191NotDimensionallyQualified" xlink:type="arc" order="176"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_06789ae9-6a59-4a68-98ff-2e916766e0d1NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinanceIncomeExpenseExplanatory_06789ae9-6a59-4a68-98ff-2e916766e0d1NotDimensionallyQualified" xlink:type="arc" order="177"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEarningsPerShareExplanatory_e1f3dd70-3c72-45dc-ac6f-e31f6d6dbf02NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfEarningsPerShareExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEarningsPerShareExplanatory_e1f3dd70-3c72-45dc-ac6f-e31f6d6dbf02NotDimensionallyQualified" xlink:type="arc" order="178"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_af0644e3-be69-4cbf-b8b3-280e2cccfd18NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfPropertyPlantAndEquipmentExplanatory_af0644e3-be69-4cbf-b8b3-280e2cccfd18NotDimensionallyQualified" xlink:type="arc" order="179"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIntangibleAssetsExplanatory_f290529b-1820-4f61-b69d-e59dbb0d91ccNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfIntangibleAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIntangibleAssetsExplanatory_f290529b-1820-4f61-b69d-e59dbb0d91ccNotDimensionallyQualified" xlink:type="arc" order="180"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfOtherAssetsExplanatory_2e1f5dac-1648-41c7-9ee8-ea9059bb9c1fNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfOtherAssetsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfOtherAssetsExplanatory_2e1f5dac-1648-41c7-9ee8-ea9059bb9c1fNotDimensionallyQualified" xlink:type="arc" order="181"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_126ad2e1-fe28-4559-ba58-38b7c94836d9NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory_126ad2e1-fe28-4559-ba58-38b7c94836d9NotDimensionallyQualified" xlink:type="arc" order="182"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfInterestsInSubsidiariesExplanatory_a16b991a-7d76-498e-9681-0708e6f99313NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfInterestsInSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfInterestsInSubsidiariesExplanatory_a16b991a-7d76-498e-9681-0708e6f99313NotDimensionallyQualified" xlink:type="arc" order="183"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialInstrumentsExplanatory_46bbae67-fbc1-4090-88fb-c363f9aaaad8NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinancialInstrumentsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialInstrumentsExplanatory_46bbae67-fbc1-4090-88fb-c363f9aaaad8NotDimensionallyQualified" xlink:type="arc" order="184"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_05c5039b-f3cd-4443-9bc4-34327cbb41bfNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsAtFairValueThroughProfitOrLossExplanatory_05c5039b-f3cd-4443-9bc4-34327cbb41bfNotDimensionallyQualified" xlink:type="arc" order="185"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_7526c5aa-25a8-44ec-b433-b71d6f9ec58aNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesExplanatory_7526c5aa-25a8-44ec-b433-b71d6f9ec58aNotDimensionallyQualified" xlink:type="arc" order="186"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_d3f6e82b-abca-478e-908e-966601460b31NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfBorrowingsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfBorrowingsExplanatory_d3f6e82b-abca-478e-908e-966601460b31NotDimensionallyQualified" xlink:type="arc" order="187"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_a470505e-d2e8-444e-81dd-4c7633f52c46NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfNoncontrollingInterestsExplanatory_a470505e-d2e8-444e-81dd-4c7633f52c46NotDimensionallyQualified" xlink:type="arc" order="188"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory_cc6c573d-57af-4d61-adcb-d9f8ac9c5745NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory_cc6c573d-57af-4d61-adcb-d9f8ac9c5745NotDimensionallyQualified" xlink:type="arc" order="189"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfLeasesExplanatory_c593a7ff-f38d-4cdb-a21d-875e8499c80fNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfLeasesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfLeasesExplanatory_c593a7ff-f38d-4cdb-a21d-875e8499c80fNotDimensionallyQualified" xlink:type="arc" order="190"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_1fce5e83-38be-4db4-b4aa-17a36fa3ae44NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinancialRiskManagementExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfFinancialRiskManagementExplanatory_1fce5e83-38be-4db4-b4aa-17a36fa3ae44NotDimensionallyQualified" xlink:type="arc" order="191"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_4fd7ed99-dcc4-4ab3-9c3f-da1c44294167NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory_4fd7ed99-dcc4-4ab3-9c3f-da1c44294167NotDimensionallyQualified" xlink:type="arc" order="192"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory_635dd04e-2776-46bf-a600-1e45fffcfe5eNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesExplanatory_635dd04e-2776-46bf-a600-1e45fffcfe5eNotDimensionallyQualified" xlink:type="arc" order="193"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_b8790a95-e16c-42e3-a4d7-de2e0f01d702NotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfIncomeTaxExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfIncomeTaxExplanatory_b8790a95-e16c-42e3-a4d7-de2e0f01d702NotDimensionallyQualified" xlink:type="arc" order="194"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_f40df29b-294c-4bd1-a14a-20983e2e02cfNotDimensionallyQualified" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_esef_cor_LineItemsNotDimensionallyQualifiedPlaceholder" xlink:to="loc_ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory_f40df29b-294c-4bd1-a14a-20983e2e02cfNotDimensionallyQualified" xlink:type="arc" order="195"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://ptv.com/role/Anchoring" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#Anchoring"/>
  <link:definitionLink xlink:role="http://ptv.com/role/Anchoring" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_f970beb3-c51d-44bb-b1e1-1207ffb0eec4" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForReconcileProfitLoss" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForReconcileProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AdjustmentsForReconcileProfitLoss" xlink:to="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_f970beb3-c51d-44bb-b1e1-1207ffb0eec4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashInDeconsolidatedSubsidiary_e6d40060-6f92-4358-95e3-75a4c4e2f90a" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_CashInDeconsolidatedSubsidiary"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_ptv_CashInDeconsolidatedSubsidiary_e6d40060-6f92-4358-95e3-75a4c4e2f90a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_92c43e57-0390-4f88-abb3-13d7bf67598d" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToOtherPartiesClassifiedAsInvestingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToOtherPartiesClassifiedAsInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashReceiptsFromRepaymentOfAdvancesAndLoansMadeToOtherPartiesClassifiedAsInvestingActivities" xlink:to="loc_ptv_CashReceiptsFromRepaymentOfCurrentReceivablesDueFromAssociatesClassifiedAsInvestingActivities_92c43e57-0390-4f88-abb3-13d7bf67598d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_4a844d22-5732-4be3-b810-ef3a450e063f" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughConversionOfConvertibleInstruments" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughConversionOfConvertibleInstruments"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughConversionOfConvertibleInstruments" xlink:to="loc_ptv_ConversionOfSubsidiaryConvertibleNoteIntoPreferredShareLiabilities_4a844d22-5732-4be3-b810-ef3a450e063f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_254c526b-e744-4298-8879-a5f390f01c65" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ProfitLossBeforeTax" xlink:to="loc_ptv_GainLossRecognizedOnDilutionOfOwnershipInterestInAssociate_254c526b-e744-4298-8879-a5f390f01c65" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseInNumberOfOrdinarySharesIssuedThroughExerciseOfShareBasedAwards_1098ca85-9ab2-4da8-b30c-b28c5eeb0336" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseInNumberOfOrdinarySharesIssuedThroughExerciseOfShareBasedAwards"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued" xlink:to="loc_ptv_IncreaseDecreaseInNumberOfOrdinarySharesIssuedThroughExerciseOfShareBasedAwards_1098ca85-9ab2-4da8-b30c-b28c5eeb0336" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_abdb73e6-776d-484e-91ea-8a673d62ad2d" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AmountOfReclassificationsOrChangesInPresentation" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AmountOfReclassificationsOrChangesInPresentation"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_AmountOfReclassificationsOrChangesInPresentation" xlink:to="loc_ptv_IncreaseDecreaseInReclassificationOfEquitySettledAwardsIntoLiabilityAwards_abdb73e6-776d-484e-91ea-8a673d62ad2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_3a00e911-fceb-41da-9886-e8570ba515b2" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ChangesInEquity" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ChangesInEquity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_ptv_IncreaseDecreaseThroughNonControllingInterestExerciseOfShareBasedAwardsInSubsidiaries_3a00e911-fceb-41da-9886-e8570ba515b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_98695bd9-8186-43af-b631-c159293dc0aa" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_ptv_IncreaseDecreaseThroughRevaluationOfDeferredTaxAssetsRelatedToShareBasedPaymentTransactionsEquity_98695bd9-8186-43af-b631-c159293dc0aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_045fd9c1-16c7-4a0e-9052-03b06f76bcc7" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInEquity" xlink:to="loc_ptv_IncreaseDecreaseThroughSettlementOfRestrictedStockUnits_045fd9c1-16c7-4a0e-9052-03b06f76bcc7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_bde09aad-b0a5-4143-83c1-3b2321d3c764" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_ptv_IncreaseDecreaseThroughVestingOfShareBasedAwardsAndNetShareExerciseEquity_bde09aad-b0a5-4143-83c1-3b2321d3c764" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseInNumberOfOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_7d39a0d2-6220-4f07-b529-7c39cc0ae173" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseInNumberOfOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInNumberOfOrdinarySharesIssued" xlink:to="loc_ptv_IncreaseInNumberOfOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_7d39a0d2-6220-4f07-b529-7c39cc0ae173" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_e0da4045-d592-4bd4-86ea-650785bd918e" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:to="loc_ptv_IncreaseThroughOrdinarySharesIssuedToSettleLiabilitiesFromShareBasedPaymentTransactions_e0da4045-d592-4bd4-86ea-650785bd918e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_1b1789a6-853b-40c4-9103-f8779778e2d2" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ChangesInPropertyPlantAndEquipment" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ChangesInPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInPropertyPlantAndEquipment" xlink:to="loc_ptv_LeaseholdImprovementsPurchasedThroughLeaseIncentives_1b1789a6-853b-40c4-9103-f8779778e2d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_NumberOfTreasurySharesPurchased_ff9384f7-8bd7-4603-a42e-a148a31296af" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_NumberOfTreasurySharesPurchased"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInNumberOfSharesOutstanding" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInNumberOfSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseInNumberOfSharesOutstanding" xlink:to="loc_ptv_NumberOfTreasurySharesPurchased_ff9384f7-8bd7-4603-a42e-a148a31296af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_OtherAssetsAndLiabilitiesNet_ddf63dce-b6fd-4a23-b1ce-28282e6d5974" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_OtherAssetsAndLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NetAssetsLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NetAssetsLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_NetAssetsLiabilities" xlink:to="loc_ptv_OtherAssetsAndLiabilitiesNet_ddf63dce-b6fd-4a23-b1ce-28282e6d5974" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_d21860b3-fdbd-436f-87d2-00182295772f" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OutflowsOfCashFromInvestingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OutflowsOfCashFromInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_OutflowsOfCashFromInvestingActivities" xlink:to="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_d21860b3-fdbd-436f-87d2-00182295772f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToPurchaseTreasuryStock_82aca1e2-cfed-422a-bbd2-e68ccfc485a2" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PaymentToPurchaseTreasuryStock"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_ptv_PaymentToPurchaseTreasuryStock_82aca1e2-cfed-422a-bbd2-e68ccfc485a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PreferredShareLiability_48d0b072-5d34-4b30-b5e8-03a8b763d98c" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PreferredShareLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CurrentLiabilities" xlink:to="loc_ptv_PreferredShareLiability_48d0b072-5d34-4b30-b5e8-03a8b763d98c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_f2ce7134-d789-4c71-ab63-674fac1aba49" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ProceedsFromIssueOfSharesToNonControllingInterests"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseThroughFinancingCashFlowsLiabilitiesArisingFromFinancingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughFinancingCashFlowsLiabilitiesArisingFromFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_IncreaseDecreaseThroughFinancingCashFlowsLiabilitiesArisingFromFinancingActivities" xlink:to="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_f2ce7134-d789-4c71-ab63-674fac1aba49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_0f79f6c0-8be1-446a-9395-4f155ed3e2fd" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_ChangesInPropertyPlantAndEquipment" xlink:to="loc_ptv_PurchaseOfPropertyPlantAndEquipmentAgainstTradeAndOtherPayables_0f79f6c0-8be1-446a-9395-4f155ed3e2fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchasesOfConvertibleNote_b96532e4-7b7d-4bdf-a51c-96d3eb37f026" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_PurchasesOfConvertibleNote"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_ptv_PurchasesOfConvertibleNote_b96532e4-7b7d-4bdf-a51c-96d3eb37f026" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ReceiptOfPaymentOfSublease_a4442284-97e4-4c9d-b1a2-5bccfb043863" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ReceiptOfPaymentOfSublease"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:to="loc_ptv_ReceiptOfPaymentOfSublease_a4442284-97e4-4c9d-b1a2-5bccfb043863" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_SettlementOfRestrictedStockUnits_8ed1a230-a588-4a4b-82c5-927361ac7ac8" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_SettlementOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_ptv_SettlementOfRestrictedStockUnits_8ed1a230-a588-4a4b-82c5-927361ac7ac8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ShortTermInvestments_82af1387-360c-4de0-ba8b-30b6e606453a" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_ShortTermInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CurrentAssets" xlink:to="loc_ptv_ShortTermInvestments_82af1387-360c-4de0-ba8b-30b6e606453a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_VestingOfRestrictedStockUnits_207c7810-85ef-4219-93e1-a7c5fd70fa9d" xlink:href="213800LVPDNO2Z9T9I39-2022-12-31.xsd#ptv_VestingOfRestrictedStockUnits"/>
    <link:definitionArc xlink:arcrole="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:to="loc_ptv_VestingOfRestrictedStockUnits_207c7810-85ef-4219-93e1-a7c5fd70fa9d" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
