<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:6df5a9a0-dc99-488a-a4d2-c29046fc13e2,g:cbe81860-23f4-4b78-82df-2e21398b72d7-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://ptv.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement"/>
  <link:calculationLink xlink:role="http://ptv.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_ed6e1e8f-843a-4ca2-857f-6b423ba1a545" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GeneralAndAdministrativeExpense_6b753a33-0561-4b9a-84ee-35737c93b0d0" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_ed6e1e8f-843a-4ca2-857f-6b423ba1a545" xlink:to="loc_ifrs-full_GeneralAndAdministrativeExpense_6b753a33-0561-4b9a-84ee-35737c93b0d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ResearchAndDevelopmentExpense_4e149630-4335-4582-941d-b87abcfaf56a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_ed6e1e8f-843a-4ca2-857f-6b423ba1a545" xlink:to="loc_ifrs-full_ResearchAndDevelopmentExpense_4e149630-4335-4582-941d-b87abcfaf56a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_79b97d66-a1cd-41f5-9e88-7c57ff4e5c73" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Revenue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossFromOperatingActivities_ed6e1e8f-843a-4ca2-857f-6b423ba1a545" xlink:to="loc_ifrs-full_Revenue_79b97d66-a1cd-41f5-9e88-7c57ff4e5c73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_176e85a3-9d8f-4766-a38d-71b2782d3857" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_58267806-ed57-484c-87b2-9af01aeb119b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_176e85a3-9d8f-4766-a38d-71b2782d3857" xlink:to="loc_ifrs-full_IncomeTaxExpenseContinuingOperations_58267806-ed57-484c-87b2-9af01aeb119b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_d5c2b069-04a8-4221-8764-3aa9954e4690" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_176e85a3-9d8f-4766-a38d-71b2782d3857" xlink:to="loc_ifrs-full_ProfitLossBeforeTax_d5c2b069-04a8-4221-8764-3aa9954e4690" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherIncome_846ee46f-e5fc-47dd-a8ef-5ef8fb48b498" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LossesOnDisposalsOfInvestments_5bc3b402-9cde-4188-a53c-dd016dbafbe8" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_LossesOnDisposalsOfInvestments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_846ee46f-e5fc-47dd-a8ef-5ef8fb48b498" xlink:to="loc_ifrs-full_LossesOnDisposalsOfInvestments_5bc3b402-9cde-4188-a53c-dd016dbafbe8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_d2076681-7bd6-40a1-b5bf-ff93a4c65aa7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_846ee46f-e5fc-47dd-a8ef-5ef8fb48b498" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementAssets_d2076681-7bd6-40a1-b5bf-ff93a4c65aa7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_64f4ad7a-6ba8-4f42-bcc5-906aac38b734" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_846ee46f-e5fc-47dd-a8ef-5ef8fb48b498" xlink:to="loc_ifrs-full_GainsLossesRecognisedWhenControlInSubsidiaryIsLost_64f4ad7a-6ba8-4f42-bcc5-906aac38b734" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherGainsLosses_3cca8ca4-0de1-4a41-8fd9-846ca7bde6ab" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherGainsLosses"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_846ee46f-e5fc-47dd-a8ef-5ef8fb48b498" xlink:to="loc_ifrs-full_OtherGainsLosses_3cca8ca4-0de1-4a41-8fd9-846ca7bde6ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_GainLossOnLossOfSignificantInfluence_55589a93-3d8a-4067-821e-2e64774b6581" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_GainLossOnLossOfSignificantInfluence"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherIncome_846ee46f-e5fc-47dd-a8ef-5ef8fb48b498" xlink:to="loc_ptv_GainLossOnLossOfSignificantInfluence_55589a93-3d8a-4067-821e-2e64774b6581" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_3e578939-97a1-48aa-85f4-ee37a8910e1a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_8492098c-9f42-4d47-a4fb-e9fd21a897f6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_3e578939-97a1-48aa-85f4-ee37a8910e1a" xlink:to="loc_ifrs-full_OtherComprehensiveIncome_8492098c-9f42-4d47-a4fb-e9fd21a897f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_92750e18-514c-4b59-b94e-d624427cf783" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_3e578939-97a1-48aa-85f4-ee37a8910e1a" xlink:to="loc_ifrs-full_ProfitLoss_92750e18-514c-4b59-b94e-d624427cf783" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherComprehensiveIncome_7535c402-da2d-4776-80ed-696191443e2a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_9bb5e6ef-53c1-4ee2-8b50-87bb6597d8b0" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_OtherComprehensiveIncome_7535c402-da2d-4776-80ed-696191443e2a" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_9bb5e6ef-53c1-4ee2-8b50-87bb6597d8b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Revenue_b9074d50-0c25-4db9-9557-e1473e9be435" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Revenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromContractsWithCustomers_aa19e526-1c0b-435c-ba7c-88fee43ba459" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RevenueFromContractsWithCustomers"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Revenue_b9074d50-0c25-4db9-9557-e1473e9be435" xlink:to="loc_ifrs-full_RevenueFromContractsWithCustomers_aa19e526-1c0b-435c-ba7c-88fee43ba459" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RevenueFromGovernmentGrants_ecef3822-2939-4289-935b-a760cfa214e4" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RevenueFromGovernmentGrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Revenue_b9074d50-0c25-4db9-9557-e1473e9be435" xlink:to="loc_ifrs-full_RevenueFromGovernmentGrants_ecef3822-2939-4289-935b-a760cfa214e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_2b7e1c59-ba56-4e16-bf7f-b58858cd7895" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncome_feeed5fb-76a6-4273-be41-2d2bb52fa8e1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_2b7e1c59-ba56-4e16-bf7f-b58858cd7895" xlink:to="loc_ifrs-full_FinanceIncome_feeed5fb-76a6-4273-be41-2d2bb52fa8e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceCosts_1227f6f9-d680-466d-832f-02a15fdc01dc" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_2b7e1c59-ba56-4e16-bf7f-b58858cd7895" xlink:to="loc_ifrs-full_FinanceCosts_1227f6f9-d680-466d-832f-02a15fdc01dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_FinanceIncomeCostsSubsidiaryPreferredShares_49e5fc2d-572b-4548-a90f-ca155f2c6ef4" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_FinanceIncomeCostsSubsidiaryPreferredShares"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_2b7e1c59-ba56-4e16-bf7f-b58858cd7895" xlink:to="loc_ptv_FinanceIncomeCostsSubsidiaryPreferredShares_49e5fc2d-572b-4548-a90f-ca155f2c6ef4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities_3ba0913e-419e-44b8-9b80-6f6bb2d11d6c" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_FinanceIncomeCost_2b7e1c59-ba56-4e16-bf7f-b58858cd7895" xlink:to="loc_ifrs-full_GainsLossesRecognisedInProfitOrLossFairValueMeasurementLiabilities_3ba0913e-419e-44b8-9b80-6f6bb2d11d6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossBeforeTax_41534e5d-6fb7-44c8-98ec-71cf66cd921a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossFromOperatingActivities_ff78e04e-6578-48c8-bb48-6e6ffe8f7b12" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_41534e5d-6fb7-44c8-98ec-71cf66cd921a" xlink:to="loc_ifrs-full_ProfitLossFromOperatingActivities_ff78e04e-6578-48c8-bb48-6e6ffe8f7b12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherIncome_18d3feb8-2405-4d1a-b5bd-314fb292d243" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_41534e5d-6fb7-44c8-98ec-71cf66cd921a" xlink:to="loc_ifrs-full_OtherIncome_18d3feb8-2405-4d1a-b5bd-314fb292d243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_FinanceIncomeCost_3fd91832-7ace-4b1f-a470-dbc05e3a6ced" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_FinanceIncomeCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_41534e5d-6fb7-44c8-98ec-71cf66cd921a" xlink:to="loc_ifrs-full_FinanceIncomeCost_3fd91832-7ace-4b1f-a470-dbc05e3a6ced" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_98a27d89-919e-4b2c-826d-1f52155b4ddf" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_41534e5d-6fb7-44c8-98ec-71cf66cd921a" xlink:to="loc_ifrs-full_ShareOfProfitLossOfAssociatesAndJointVenturesAccountedForUsingEquityMethod_98a27d89-919e-4b2c-826d-1f52155b4ddf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLoss_b2578482-3eee-4ee9-bcef-19bda5149323" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ImpairmentLossRecognisedInProfitOrLoss"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLossBeforeTax_41534e5d-6fb7-44c8-98ec-71cf66cd921a" xlink:to="loc_ifrs-full_ImpairmentLossRecognisedInProfitOrLoss_b2578482-3eee-4ee9-bcef-19bda5149323" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://ptv.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1"/>
  <link:calculationLink xlink:role="http://ptv.com/role/StatementofcomprehensiveincomeprofitorlossbyfunctionofexpenseStatement_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_93803a72-364e-4da7-b373-60c6690197ba" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_d3b5f150-d166-4ebf-a801-79700150dbd7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_93803a72-364e-4da7-b373-60c6690197ba" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent_d3b5f150-d166-4ebf-a801-79700150dbd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_bd86b27b-a4d4-4f56-8915-40f3f88df483" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_93803a72-364e-4da7-b373-60c6690197ba" xlink:to="loc_ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests_bd86b27b-a4d4-4f56-8915-40f3f88df483" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_66263c18-61b0-4b7f-a03c-2e9a46ad77db" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_be909080-622d-45e6-b757-51d63e3e6e30" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_66263c18-61b0-4b7f-a03c-2e9a46ad77db" xlink:to="loc_ifrs-full_ProfitLossAttributableToNoncontrollingInterests_be909080-622d-45e6-b757-51d63e3e6e30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_486a4c12-5372-4ae9-aa90-7755659d0042" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ProfitLoss_66263c18-61b0-4b7f-a03c-2e9a46ad77db" xlink:to="loc_ifrs-full_ProfitLossAttributableToOwnersOfParent_486a4c12-5372-4ae9-aa90-7755659d0042" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://ptv.com/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#StatementoffinancialpositioncurrentnoncurrentStatement"/>
  <link:calculationLink xlink:role="http://ptv.com/role/StatementoffinancialpositioncurrentnoncurrentStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentContractLiabilities_fe4c4b77-e52a-4c80-ae33-8c12c53761d6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentContractLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ifrs-full_CurrentContractLiabilities_fe4c4b77-e52a-4c80-ae33-8c12c53761d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLeaseLiabilities_34509757-b093-4c0c-aec9-c4cdb922b7f5" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ifrs-full_CurrentLeaseLiabilities_34509757-b093-4c0c-aec9-c4cdb922b7f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentPayables_5beca34f-c2a3-42f5-8e60-8224de07b08e" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ifrs-full_TradeAndOtherCurrentPayables_5beca34f-c2a3-42f5-8e60-8224de07b08e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NotesAndDebenturesIssued_2a35b5c8-f4ab-4f9a-b27a-2339479907b9" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NotesAndDebenturesIssued"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ifrs-full_NotesAndDebenturesIssued_2a35b5c8-f4ab-4f9a-b27a-2339479907b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_c6669ccc-ce4c-454f-880c-3c7de4cf2ad6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentDerivativeFinancialLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ifrs-full_CurrentDerivativeFinancialLiabilities_c6669ccc-ce4c-454f-880c-3c7de4cf2ad6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PreferredShareLiability_80b49bb9-8a4a-41d2-a535-a5024b56f60c" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_PreferredShareLiability"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ptv_PreferredShareLiability_80b49bb9-8a4a-41d2-a535-a5024b56f60c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCurrentLiabilities_9eb0aaf2-0462-44c0-884b-c463434aa495" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherCurrentLiabilities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ifrs-full_OtherCurrentLiabilities_9eb0aaf2-0462-44c0-884b-c463434aa495" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_1aaf54ca-6a89-4f29-a790-35303d942781" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentPortionOfLongtermBorrowings"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentLiabilities_1697d45f-f86e-46cf-af61-fc1967e00aeb" xlink:to="loc_ifrs-full_CurrentPortionOfLongtermBorrowings_1aaf54ca-6a89-4f29-a790-35303d942781" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_e35dba1a-dd98-4596-8e7a-b48d102830d8" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_DeferredTaxLiabilities_963385a3-d8cd-4cdc-8381-834f907de366" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_DeferredTaxLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_e35dba1a-dd98-4596-8e7a-b48d102830d8" xlink:to="loc_ifrs-full_DeferredTaxLiabilities_963385a3-d8cd-4cdc-8381-834f907de366" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLeaseLiabilities_306f71e0-4b7c-469f-87d5-b6ea40f09475" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_e35dba1a-dd98-4596-8e7a-b48d102830d8" xlink:to="loc_ifrs-full_NoncurrentLeaseLiabilities_306f71e0-4b7c-469f-87d5-b6ea40f09475" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LongtermBorrowings_c79f8dd1-07a7-4a39-be4d-b1688dd1fbc2" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_LongtermBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_e35dba1a-dd98-4596-8e7a-b48d102830d8" xlink:to="loc_ifrs-full_LongtermBorrowings_c79f8dd1-07a7-4a39-be4d-b1688dd1fbc2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_1f48afbb-9c76-4fb2-ab4a-6e3446159ec3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentLiabilities_e35dba1a-dd98-4596-8e7a-b48d102830d8" xlink:to="loc_ifrs-full_LiabilitiesFromSharebasedPaymentTransactions2011_1f48afbb-9c76-4fb2-ab4a-6e3446159ec3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_TradeAndOtherCurrentReceivables_34409728-b983-45c3-9198-fdcd3e44cdf3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_TradeAndOtherCurrentReceivables"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:to="loc_ifrs-full_TradeAndOtherCurrentReceivables_34409728-b983-45c3-9198-fdcd3e44cdf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentPrepaidExpenses_1b16a349-f364-4a73-b592-57a8db8b4c8b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentPrepaidExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:to="loc_ifrs-full_CurrentPrepaidExpenses_1b16a349-f364-4a73-b592-57a8db8b4c8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentFinanceLeaseReceivables_d1cb15bb-6b4e-452d-804f-ff2fa45df84f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentFinanceLeaseReceivables"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:to="loc_ifrs-full_CurrentFinanceLeaseReceivables_d1cb15bb-6b4e-452d-804f-ff2fa45df84f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RestrictedCashAndCashEquivalents_fa8c8ce5-bc0f-49aa-9381-b544ef40574c" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:to="loc_ifrs-full_RestrictedCashAndCashEquivalents_fa8c8ce5-bc0f-49aa-9381-b544ef40574c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashAndCashEquivalents_42c7987f-02c9-4395-a588-dba7b8715440" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashAndCashEquivalents"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:to="loc_ifrs-full_CashAndCashEquivalents_42c7987f-02c9-4395-a588-dba7b8715440" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentReceivablesDueFromAssociates_17969f0d-9287-478d-bc39-4273f460fa85" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentReceivablesDueFromAssociates"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:to="loc_ifrs-full_CurrentReceivablesDueFromAssociates_17969f0d-9287-478d-bc39-4273f460fa85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentTaxAssetsCurrent_3baf8523-d17d-4773-aec2-8152c39d4930" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentTaxAssetsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CurrentAssets_94d89ee5-9326-43a1-ac61-3acd26263031" xlink:to="loc_ifrs-full_CurrentTaxAssetsCurrent_3baf8523-d17d-4773-aec2-8152c39d4930" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Assets_9eabd8c7-809c-45f3-8136-f5ee791ffb69" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentAssets_2f125a3f-2e77-4b3f-8017-6a3f970ffe8e" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_9eabd8c7-809c-45f3-8136-f5ee791ffb69" xlink:to="loc_ifrs-full_CurrentAssets_2f125a3f-2e77-4b3f-8017-6a3f970ffe8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_3312042e-41f6-450d-a7c9-1a264f31f63a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Assets_9eabd8c7-809c-45f3-8136-f5ee791ffb69" xlink:to="loc_ifrs-full_NoncurrentAssets_3312042e-41f6-450d-a7c9-1a264f31f63a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_71da8425-0dd0-4583-b670-839929d353d6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CurrentLiabilities_4101a38d-569a-41f9-9b9b-82febaf232dd" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CurrentLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_71da8425-0dd0-4583-b670-839929d353d6" xlink:to="loc_ifrs-full_CurrentLiabilities_4101a38d-569a-41f9-9b9b-82febaf232dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentLiabilities_f4ec3efc-f6c2-412e-9e5f-c9480d88118c" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Liabilities_71da8425-0dd0-4583-b670-839929d353d6" xlink:to="loc_ifrs-full_NoncurrentLiabilities_f4ec3efc-f6c2-412e-9e5f-c9480d88118c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_26d4431f-aa4d-4c79-8062-4b54cd8843f1" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_MergerReserve_ab865b61-dea2-4f95-820c-6ea47cc6b209" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_MergerReserve"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_26d4431f-aa4d-4c79-8062-4b54cd8843f1" xlink:to="loc_ifrs-full_MergerReserve_ab865b61-dea2-4f95-820c-6ea47cc6b209" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherReserves_d5af3506-7ac6-4f3d-aa76-7fe46848ec72" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_26d4431f-aa4d-4c79-8062-4b54cd8843f1" xlink:to="loc_ifrs-full_OtherReserves_d5af3506-7ac6-4f3d-aa76-7fe46848ec72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_b6e89aef-2f61-4c03-9b30-5b1431533ccc" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_26d4431f-aa4d-4c79-8062-4b54cd8843f1" xlink:to="loc_ifrs-full_ReserveOfExchangeDifferencesOnTranslation_b6e89aef-2f61-4c03-9b30-5b1431533ccc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IssuedCapital_3b246948-547d-4e9a-b750-e6a46d911830" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IssuedCapital"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_26d4431f-aa4d-4c79-8062-4b54cd8843f1" xlink:to="loc_ifrs-full_IssuedCapital_3b246948-547d-4e9a-b750-e6a46d911830" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_SharePremium_78c40cac-be06-43ea-a985-b9fb796aa5a3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_SharePremium"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_26d4431f-aa4d-4c79-8062-4b54cd8843f1" xlink:to="loc_ifrs-full_SharePremium_78c40cac-be06-43ea-a985-b9fb796aa5a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RetainedEarnings_4696f13c-af42-48b0-8db9-0205431b22c6" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RetainedEarnings"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAttributableToOwnersOfParent_26d4431f-aa4d-4c79-8062-4b54cd8843f1" xlink:to="loc_ifrs-full_RetainedEarnings_4696f13c-af42-48b0-8db9-0205431b22c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAndLiabilities_1877f9a4-bfbe-40ac-9370-cdd74b0cc099" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_EquityAndLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Liabilities_596ca4ec-59b5-44a6-a229-179cded929aa" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_1877f9a4-bfbe-40ac-9370-cdd74b0cc099" xlink:to="loc_ifrs-full_Liabilities_596ca4ec-59b5-44a6-a229-179cded929aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_c4eccb01-0259-45a8-b38d-228ea48c7323" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Equity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_EquityAndLiabilities_1877f9a4-bfbe-40ac-9370-cdd74b0cc099" xlink:to="loc_ifrs-full_Equity_c4eccb01-0259-45a8-b38d-228ea48c7323" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_Equity_cc585029-3bd2-418f-9509-cb33c10a8390" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_Equity"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EquityAttributableToOwnersOfParent_45d1e4a8-01b0-49dc-853c-353626598078" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_EquityAttributableToOwnersOfParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_cc585029-3bd2-418f-9509-cb33c10a8390" xlink:to="loc_ifrs-full_EquityAttributableToOwnersOfParent_45d1e4a8-01b0-49dc-853c-353626598078" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncontrollingInterests_7fe65d7a-0267-411d-97b0-f973a00c5cb3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncontrollingInterests"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_Equity_cc585029-3bd2-418f-9509-cb33c10a8390" xlink:to="loc_ifrs-full_NoncontrollingInterests_7fe65d7a-0267-411d-97b0-f973a00c5cb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PropertyPlantAndEquipment_56658975-df5b-446b-ab4f-e22514cb41cd" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:to="loc_ifrs-full_PropertyPlantAndEquipment_56658975-df5b-446b-ab4f-e22514cb41cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RightofuseAssets_d3c35f78-712d-4065-9a8e-5e9789631b06" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RightofuseAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:to="loc_ifrs-full_RightofuseAssets_d3c35f78-712d-4065-9a8e-5e9789631b06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_0217fa31-129f-43b4-8a4c-d7f1e3b9b14f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:to="loc_ifrs-full_IntangibleAssetsOtherThanGoodwill_0217fa31-129f-43b4-8a4c-d7f1e3b9b14f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss_cacdc8b7-05cd-4360-9d53-01116086caa4" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:to="loc_ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLoss_cacdc8b7-05cd-4360-9d53-01116086caa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InvestmentsInAssociates_c680cc33-ba95-4ea6-898d-7a96bd1b5933" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_InvestmentsInAssociates"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:to="loc_ifrs-full_InvestmentsInAssociates_c680cc33-ba95-4ea6-898d-7a96bd1b5933" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_NoncurrentFinanceLeaseReceivables_68b4f108-8c92-45c6-9e66-9d8d16ce7b68" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_NoncurrentFinanceLeaseReceivables"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:to="loc_ifrs-full_NoncurrentFinanceLeaseReceivables_68b4f108-8c92-45c6-9e66-9d8d16ce7b68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherNoncurrentAssets_7b3c3dd7-a825-4bc5-bdc3-62a7cded51c7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherNoncurrentAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_NoncurrentAssets_9054c248-7909-4590-a6fa-9f6216345ae5" xlink:to="loc_ifrs-full_OtherNoncurrentAssets_7b3c3dd7-a825-4bc5-bdc3-62a7cded51c7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://ptv.com/role/StatementofchangesinequityStatement" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#StatementofchangesinequityStatement"/>
  <link:calculationLink xlink:role="http://ptv.com/role/StatementofchangesinequityStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ComprehensiveIncome_11324c2b-66c7-4f51-a1f6-74a53914971a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ComprehensiveIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_e3a459bf-eaae-480b-82c6-3da2f47e62aa" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_11324c2b-66c7-4f51-a1f6-74a53914971a" xlink:to="loc_ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationBeforeTax_e3a459bf-eaae-480b-82c6-3da2f47e62aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_7e9e27e7-d067-4951-8a7a-d3bcaf3466b4" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_ComprehensiveIncome_11324c2b-66c7-4f51-a1f6-74a53914971a" xlink:to="loc_ifrs-full_ProfitLoss_7e9e27e7-d067-4951-8a7a-d3bcaf3466b4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://ptv.com/role/StatementofcashflowsindirectmethodStatement" xlink:type="simple" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#StatementofcashflowsindirectmethodStatement"/>
  <link:calculationLink xlink:role="http://ptv.com/role/StatementofcashflowsindirectmethodStatement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_c9352654-404b-4c67-816b-63a24c1a5cdb" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_ProceedsFromSalesOrMaturityOfFinancialInstrumentsClassifiedAsInvestingActivities_c9352654-404b-4c67-816b-63a24c1a5cdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_feaa1c43-c97c-484f-b1e7-699046a8191b" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_PurchaseOfFinancialInstrumentsClassifiedAsInvestingActivities_feaa1c43-c97c-484f-b1e7-699046a8191b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_9164eb41-d5ce-41e2-be66-f686ccc2c0ed" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_PurchaseOfInvestmentsOtherThanInvestmentsAccountedForUsingEquityMethod_9164eb41-d5ce-41e2-be66-f686ccc2c0ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_44dfb219-a205-4a83-9d44-54d2f8895acb" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_OtherCashPaymentsToAcquireEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_44dfb219-a205-4a83-9d44-54d2f8895acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_39a0f147-1c07-41e9-92fd-2578d2a66b13" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_OtherCashReceiptsFromSalesOfEquityOrDebtInstrumentsOfOtherEntitiesClassifiedAsInvestingActivities_39a0f147-1c07-41e9-92fd-2578d2a66b13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ReceiptOfPaymentOfSublease_c69588bd-c7ad-43ce-8869-5dfc23b0d440" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_ReceiptOfPaymentOfSublease"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ptv_ReceiptOfPaymentOfSublease_c69588bd-c7ad-43ce-8869-5dfc23b0d440" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_6c29ccc6-64c4-49ed-8fb7-e510074632c7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_6c29ccc6-64c4-49ed-8fb7-e510074632c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PurchasesOfConvertibleNote_f600f4ee-493b-4da7-8ac9-e2df63b9ce4d" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_PurchasesOfConvertibleNote"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ptv_PurchasesOfConvertibleNote_f600f4ee-493b-4da7-8ac9-e2df63b9ce4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_89d0a2e7-9b46-4827-9199-c289fb118616" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_PurchaseOfIntangibleAssetsClassifiedAsInvestingActivities_89d0a2e7-9b46-4827-9199-c289fb118616" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_e602fbed-d16d-4b8d-9314-734e77fdf712" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_CashFlowsFromLosingControlOfSubsidiariesOrOtherBusinessesClassifiedAsInvestingActivities_e602fbed-d16d-4b8d-9314-734e77fdf712" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_859d5594-e6f5-4a80-80e6-bff35ec362bd" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ifrs-full_ProceedsFromSalesOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities_859d5594-e6f5-4a80-80e6-bff35ec362bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_9fba5a93-a873-45b3-80c0-049a4cb0172e" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_c0cb52ee-db9d-4bc6-8f4e-8bafa5f29024" xlink:to="loc_ptv_PaymentToAcquireShortTermNotesReceivableFromAssociate_9fba5a93-a873-45b3-80c0-049a4cb0172e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_f875ebf6-4bbc-4b88-8940-aead465310a9" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ptv_AdjustmentsForIncreaseDecreaseInDeferredRevenue_f875ebf6-4bbc-4b88-8940-aead465310a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_424b82ac-2aa8-4620-8906-731852e47013" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForDepreciationAndAmortisationExpense_424b82ac-2aa8-4620-8906-731852e47013" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets_70e7ffd9-e944-4bfe-a4b1-4cc3c0977c8d" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets_70e7ffd9-e944-4bfe-a4b1-4cc3c0977c8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_615a32a3-f887-499e-907d-bafce76df6a3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_InterestPaidClassifiedAsOperatingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_InterestPaidClassifiedAsOperatingActivities_615a32a3-f887-499e-907d-bafce76df6a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_bba7f25b-e5b0-4381-9c09-538b4b806bac" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForUndistributedProfitsOfInvestmentsAccountedForUsingEquityMethod_bba7f25b-e5b0-4381-9c09-538b4b806bac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProfitLoss_60762e9b-1d6e-4859-a344-e7433ca196d7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProfitLoss"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_ProfitLoss_60762e9b-1d6e-4859-a344-e7433ca196d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets_22052516-75a4-4dc1-8613-37781e744384" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInOtherCurrentAssets_22052516-75a4-4dc1-8613-37781e744384" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_f0a67a29-28f2-4163-8b95-fbf4851bfa64" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable_f0a67a29-28f2-4163-8b95-fbf4851bfa64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates_07be6b88-f487-4013-9996-987953846004" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalOfInvestmentsInSubsidiariesJointVenturesAndAssociates_07be6b88-f487-4013-9996-987953846004" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_082f095a-8cb9-4a56-9cb7-0053fff7271a" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForFairValueGainsLosses"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForFairValueGainsLosses_082f095a-8cb9-4a56-9cb7-0053fff7271a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_28fecb0f-88a1-4ec8-b706-f040bbbd7c34" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities_28fecb0f-88a1-4ec8-b706-f040bbbd7c34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForSharebasedPayments_c0a7d4cd-4730-4eb7-bbcd-9f1a6efefc80" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForSharebasedPayments_c0a7d4cd-4730-4eb7-bbcd-9f1a6efefc80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_962b9621-8a31-4fbe-ada4-18ef3426fac3" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForIncomeTaxExpense"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForIncomeTaxExpense_962b9621-8a31-4fbe-ada4-18ef3426fac3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherOperatingPayables_5a57911c-19bf-4c0d-80f1-ae21cc390eba" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInOtherOperatingPayables"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForIncreaseDecreaseInOtherOperatingPayables_5a57911c-19bf-4c0d-80f1-ae21cc390eba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_788ef5ff-241c-496b-b880-e6a390eba6df" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForLossesGainsOnDisposalOfNoncurrentAssets_788ef5ff-241c-496b-b880-e6a390eba6df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForFinanceCosts_9b05afeb-0502-4710-a208-423acf81da82" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForFinanceCosts"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForFinanceCosts_9b05afeb-0502-4710-a208-423acf81da82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_3dcd06b8-decc-4a89-ae91-864e0cfd934c" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_InterestReceivedClassifiedAsOperatingActivities"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_InterestReceivedClassifiedAsOperatingActivities_3dcd06b8-decc-4a89-ae91-864e0cfd934c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentsForGainOnLossOfSignificantInfluence_cfd03ba9-21cd-4a69-8133-0c94101f02bd" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_AdjustmentsForGainOnLossOfSignificantInfluence"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ptv_AdjustmentsForGainOnLossOfSignificantInfluence_cfd03ba9-21cd-4a69-8133-0c94101f02bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_AdjustmentOfImpairmentOfInvestmentInAssociate_35344b20-7741-4327-9eed-953f432cce60" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_AdjustmentOfImpairmentOfInvestmentInAssociate"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ptv_AdjustmentOfImpairmentOfInvestmentInAssociate_35344b20-7741-4327-9eed-953f432cce60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_236993a3-bd6c-4f96-8d52-eb21fd37ab57" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables"/>
    <link:calculationArc order="20" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAndOtherReceivables_236993a3-bd6c-4f96-8d52-eb21fd37ab57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_d7635fc8-57b9-46e2-a9bf-8ac8ba3f233f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment"/>
    <link:calculationArc order="21" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForGainLossOnDisposalsPropertyPlantAndEquipment_d7635fc8-57b9-46e2-a9bf-8ac8ba3f233f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_ae8d9724-88e3-495c-b8fd-d09030be7e12" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities"/>
    <link:calculationArc order="22" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsOperatingActivities_ae8d9724-88e3-495c-b8fd-d09030be7e12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_230538fd-3d78-4e11-9170-7eb8a14a019d" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives"/>
    <link:calculationArc order="23" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_4a2fbe05-774f-40ae-84cc-cb5220ccfb32" xlink:to="loc_ifrs-full_AdjustmentsForGainsLossesOnChangeInFairValueOfDerivatives_230538fd-3d78-4e11-9170-7eb8a14a019d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_4a858470-8d8b-4cb9-b3fc-d58e0a701757" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_2987bfd4-9b91-437b-a40e-d311db8a98ba" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_4a858470-8d8b-4cb9-b3fc-d58e0a701757" xlink:to="loc_ifrs-full_CashFlowsFromUsedInOperatingActivities_2987bfd4-9b91-437b-a40e-d311db8a98ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_40536338-f5db-46a6-9e12-ab6e70969924" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_4a858470-8d8b-4cb9-b3fc-d58e0a701757" xlink:to="loc_ifrs-full_CashFlowsFromUsedInInvestingActivities_40536338-f5db-46a6-9e12-ab6e70969924" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_62837fef-45f7-44cb-9901-d93e48948625" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_4a858470-8d8b-4cb9-b3fc-d58e0a701757" xlink:to="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_62837fef-45f7-44cb-9901-d93e48948625" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_494e0bf0-45c0-4819-914d-fe191ce4ed54" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_IncreaseDecreaseInCashAndCashEquivalents_4a858470-8d8b-4cb9-b3fc-d58e0a701757" xlink:to="loc_ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents_494e0bf0-45c0-4819-914d-fe191ce4ed54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_69c9dd3f-2f2a-4965-9528-c128ac27698f" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities_69c9dd3f-2f2a-4965-9528-c128ac27698f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_3e1e3084-b5b7-4b51-83a9-c67a803ddfe7" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_RepaymentsOfNoncurrentBorrowings"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_RepaymentsOfNoncurrentBorrowings_3e1e3084-b5b7-4b51-83a9-c67a803ddfe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_e99105de-9c2a-40b4-a888-5e4f33f78fba" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures_e99105de-9c2a-40b4-a888-5e4f33f78fba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromExerciseOfWarrants_df3ac71f-86dd-4ed3-b712-c169ac38ee06" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_ProceedsFromExerciseOfWarrants"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ptv_ProceedsFromExerciseOfWarrants_df3ac71f-86dd-4ed3-b712-c169ac38ee06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromCurrentBorrowings_95b0e653-26f5-4faf-a450-cd95b68e3e25" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromCurrentBorrowings"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_ProceedsFromCurrentBorrowings_95b0e653-26f5-4faf-a450-cd95b68e3e25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_VestingOfRestrictedStockUnits_c045e60f-44e7-4d02-887c-d5f7dde208a9" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_VestingOfRestrictedStockUnits"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ptv_VestingOfRestrictedStockUnits_c045e60f-44e7-4d02-887c-d5f7dde208a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_SettlementOfRestrictedStockUnits_5cb58f40-7653-4e5f-8b95-892612d3f960" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_SettlementOfRestrictedStockUnits"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ptv_SettlementOfRestrictedStockUnits_5cb58f40-7653-4e5f-8b95-892612d3f960" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_51e874c5-364b-49f1-895e-5b9016966b8e" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_OtherInflowsOutflowsOfCashClassifiedAsFinancingActivities_51e874c5-364b-49f1-895e-5b9016966b8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromIssueOfPreferenceShares_bf3c062c-47c8-43e8-a96a-8e5f0452e160" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromIssueOfPreferenceShares"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_ProceedsFromIssueOfPreferenceShares_bf3c062c-47c8-43e8-a96a-8e5f0452e160" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_10765d67-90fe-417a-b5c5-5cdc27001474" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_PaymentsFromChangesInOwnershipInterestsInSubsidiaries_10765d67-90fe-417a-b5c5-5cdc27001474" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_ea163de3-0352-4516-addc-3a6495e50480" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromNoncurrentBorrowings"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_ProceedsFromNoncurrentBorrowings_ea163de3-0352-4516-addc-3a6495e50480" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_DistributionToTalShareholders_dbff7f40-3557-4f75-b1ec-1e83ffc57db6" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_DistributionToTalShareholders"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ptv_DistributionToTalShareholders_dbff7f40-3557-4f75-b1ec-1e83ffc57db6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ifrs-full_ProceedsFromExerciseOfOptions_0e56c795-439e-44de-89af-2dfdc0ab1e26" xlink:href="http://xbrl.ifrs.org/taxonomy/2020-03-16/full_ifrs/full_ifrs-cor_2020-03-16.xsd#ifrs-full_ProceedsFromExerciseOfOptions"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ifrs-full_ProceedsFromExerciseOfOptions_0e56c795-439e-44de-89af-2dfdc0ab1e26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_8b628040-0f51-4deb-ac6d-8a40abead89a" xlink:href="213800LVPDNO2Z9T9I39-2021-12-31.xsd#ptv_ProceedsFromIssueOfSharesToNonControllingInterests"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ifrs-full_CashFlowsFromUsedInFinancingActivities_18f61093-0f7a-4c53-af58-eb8710e45f95" xlink:to="loc_ptv_ProceedsFromIssueOfSharesToNonControllingInterests_8b628040-0f51-4deb-ac6d-8a40abead89a" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
